Title of Invention	“METHOD FOR THE PRODUCTION OF CYCLOALIPHATIC AMINES”
Abstract	The invention relates to a method for producing cycloaliphatic amines by hydrogenation of the corresponding aromatic compounds with a gas containing hydrogen at a temperature of 30 to 280°C and a pressure of 50 - 350 bar, n the presence of ruthenium-containing catalysts, characterised in that the hydrogenation is carried out in the presence of 1 to 500 wt. %, based on the catalyst (calculated as elementary ruthenium (Ru)) and suspended inorganic adjuncts and the use of the inventive cycloaliphatic amines as synthetic building blocks.

Title of Invention

“METHOD FOR THE PRODUCTION OF CYCLOALIPHATIC AMINES”

Abstract

The invention relates to a method for producing cycloaliphatic amines by hydrogenation of the corresponding aromatic compounds with a gas containing hydrogen at a temperature of 30 to 280°C and a pressure of 50 - 350 bar, n the presence of ruthenium-containing catalysts, characterised in that the hydrogenation is carried out in the presence of 1 to 500 wt. %, based on the catalyst (calculated as elementary ruthenium (Ru)) and suspended inorganic adjuncts and the use of the inventive cycloaliphatic amines as synthetic building blocks.

Full Text	FORM 2 THE PATENTS ACT, 1970 (39 of 1970) & THE PATENTS R ULES, 2003 COMPLETE SPECIFICATION (See section 10, rule 13) "METHOD FOR THE PRODUCTION OF CYCLOALIPHATIC AMINES" BASF SE, a German company, of 67056 Ludwigshafen, Germany; The following specification particularly describes the invention and the manner in which it is to be performed. Method for the production of cycloaliphatic amines Description The present invention relates to a process for preparing cycloaliphatic amines by hydrogenating the corresponding aromatic compounds in the presence of ruthenium (Ru)-comprising catalysts, in the presence of sjspended inorganic additives. The present invention further relates to the use of the cycloaliphatic amines thus obtainable. US 2,606,925 describes the hydrogenation of aromatic compounds which are substituted directly on the aromatic ring via nitrsgen atoms (for example aromatic amines or nitro compounds) to the corresponding cycloaliphatic compounds. The catalysts used are elemental ruthenium metal, ruthenium oxides, ruthenium salts, ruthenium sulfides and ruthenium sulfates. Optimal results can be achieved according to this document when the ruthenium is present in finely distributed form. However, no method of preparing these catalysts is described. In US 2,494,563, finely divided Ru catalysts aro used for the hydrogenation of aromatic diamines to the corresponding aliphatic diamines. A method for preparing very small ruthenium dioxide particles by reacting RuCb solution with NaOH in the aqueous phase, wasning and drying is described in CA-A-860855. This affords crystal sizes less than 50 nm. A preferred use specified for the powder obtained was the production of electrical resistors. DE-A-2132547 discloses a process for hydrogenating aromatic compounds to the corresponding cycloaliphatic. For the hydrogenation, a catalyst based on oxide hydrates of Ru is used. The catalyst is prepared by precipitation from an aqueous solution of a ruthenium salt by addition of alkali metal hydroxide solution. The ruthenium oxide hydrate thus obtained can be used directly in the process or be subjected to drying before use. After the drying, the catalyst, according to the disclosure, is present in the form of powder with particle sizes in the range from 4 to 6 nm, the Ru being present in the resulting dry powder as Ru(IV) oxide hydrate with approx. 50% by weight of Ru. DE 101 19 135 A1 describes the continuous preparation of bis(4-aminocyclohexyl)-methane by hydrogenation of bis(4-aminophenyl)methane with the aid of a pulverulent ruthenium catalyst. The ruthenium was used applied to an inert support material, e.g. Al2O3, and with a particle size of 5-150 urn. US 5,214,212 teaches the addition of metal salts as promoters in a process for hydrogenating aromatic amines. According to the disclosure, the addition of promoters leads to an improvement in the reaction rate ard to a reduction in by-product formation. The metal salts were used in concentrations of from 0.3% to 10% based on the aromatic amine. US 3,864,361 describes the preparation of 2,5-dimethylpyrrolidone by reduction of 2,5-dimethylpyrrole in the presence of finely divided, unsupported RuC>2. After the hydrogenation has ended, the catalyst is removed by filtration. According to the disclosure, the removal of the Ru catalyst can tie improved by the addition of AI2O3 as a filtering aid. The prior art teaches the use of heterogeneous Ru catalysts with small particle sizes, which should be present in very fine distribution in the reaction mixture. When such catalysts are used in an industrial scale process, however, it is found that the small catalyst particles form relatively large agglomerates during the hydrogenation, which can then settle out in the reactor. This firstly removes a portion of the amount of catalyst from the process; secondly, the resulting deposits can cause blockages which lead to disruption in the course of operation. In the aromatic starting materials which are used in the process for preparing cycloaliphatic amines, there are typically small amounts of by-products which generally cannot be removed quantitatively during the purification of the starting materials. These by-products can poison the ruthenium catalyst and hence reduce the space-time yield of the process. In the case of the hydrogenation of bis(4-amincphenyl)methane or bis(4-amino-3-methylphenyl)methane to the particular cycknexyl derivatives, these by-products are principally the hydrochlorides of the aromatic starting amines and higher-boiling aromatic products. Even when the chlorine content of the particula - starting materials is higher than 1 ppm or the concentration of higher-boiling products exceeds the value of 2% by weight, considerable losses in the space-time yield can arise. It was therefore an object of the present inventi :>n to provide a process for preparing cycloaliphatic compounds which has a high spece-time yield. In addition, the intention was to develop a process which ensures stable industrial scale operation and reduces the problems which occur through agglomeration of catalyst particles and the resulting blockages. Furthermore, with the aid of the process according to the invention, the yield of product shall be increased and the forrration of by-products reduced, especially in the case of use of starting materials which ccmprise a certain degree of troublesome by-products. Thus, the intention was to ensure stable production operation overall, and a high yield and selectivity. According to the invention, the object is achieved by a process for preparing cycloaliphatic amines by hydrogenating the corresponding aromatic compounds with hydrogen-comprising gas at a temperature of from 30 to 280°C and a pressure of 50 -350 bar, in the presence of ruthenium catalysts, which comprises performing the hydrogenation in the presence of from 1 % by weight to 500% by weight, based on the catalyst (calculated as elemental ruthenium), of suspended inorganic additives. In the process according to the invention, arorratic compounds which can be hydrogenated to cycloaliphatic amines are used. Aromatic compounds which can be hydrogena:ed to cycloaliphatic amines are typically mono- or polycyclic aromatic compounds which comprise one or more nitrogen-containing substituents. In a preferred embodiment, aromatic compounds with one or more nitrogen-containing substituents are used, in which the nitrogen atom of the nitrogen-containing substituent is bonded directly on the aromatic ring (N-substituted aromatic compounds). ' Preference is given to using aromatic mono-, c i- or polyamines which can be hydrogenated to the corresponding cycloaliphcitic amines. Useful aromatic amines include mono- or polycyclic aromatic compounds with one or more amine groups, for example: aromatic monoamines such as aniline, the isomeric toluidines, the isomeric xylidines, 1- or 2-aminonaphthalene, benzidine and substituted benzidines; aromatic diamines such as the isomeric phenylenediamines, the isomeric tolylenediamines, the isomeric diaminonaphthalenes, 4,4'-diamino-3,3'-dimethyldiphenylmethane, 4,4'-diamino-3,B'.S.S'-tetramethyldiphenylmethane and 4,4'-diaminodiphenylmethane; or aromatic polyamines such as polymeric MDA (polymethylenepolyphenylamine). The aromatic compounds which can be hydrogenated to cycloaliphatic amines and which are used may also be aromatics with nit*o, nitrile and urethane groups as substituents on the aromatic ring, for example aromatic compounds with nitro groups as substituents, such as nitrobenzene, nitrotoluene, dinitrobenzene, dinitrotoluene and the isomeric nitroanilines; aromatic compounds with nitrile groups as substituents, such as benzonitrile, tolunitrile or o-aminobenzonitrile; or aromatic compounds with urethane groups as substituents, such as the dialkylurethanes which are formed from diphenylmethane 4,4'-diisocyanate, diphenylmethane 2,4'-diisocyanate or diphenylmethane 2,2'-diisocyanate, and aliphatic alcohols such as Ci-Ce-alcohols, especially n-tutanol, the dialkylurethanes which are formed from tolylene 2,4-diisocyanate or tolylene 2,6-diisocyanate, and aliphatic alcohols such as C1-C6-alcohols, especially n-butanol, the dialkylurethanes which are formed from polymeric diphenylmethane diisocyanate and aliphatic alcohols such as C1-C6-alcohols, especially n-butanol, the dialkylurethanes which are formed from phenylene 2,4-diisocyanate or phenylene 2,6-diisocyanate, and aliphatic alcohols such as C1-C6-alcohols, especially n-butanol, or the dialkylurethanes which are formed from naphthylene 1,5-diisocyanate and aliphatic alcohols such as Ci-Ce-alcohols, especially n-butanol. In addition to the substituents which can be hydrogenated to amine groups, the aromatic compounds may have no further substituents or they may bear one or more further substituents, for example alkyl, cycloalkyl, aryl, heteroaryl, halogen, haloalkyl, silyl, hydroxyl, alkoxy, aryloxy, carboxyl or alkoxycarbonyl substituents. Preference is given to using, in the process, anmatic amines such as the aforementioned aromatic mono-, di- and/or pol/amines. Particular preference is given to using polymer c MDA, aniline, 2,4-diaminotoluene, 2,6-diaminotoluene, o-phenylenediamine, m-phenylenediamine, p-phenylenediamine, 4,4'-diamino-3,3'-dimethyldiphenylrnethane, 4,4,-diamino-3,3',5,5,-tetramethyldiphenyl- methane and/or 4,4'-diaminodiphenylmethane in the process. Very particular preference is given to using aniiine, 4,4'-diamino-3,3'-dimethyldiphenyl- methane, 4,4'-diamino-3,3',5,5'-tetramethyldiphenylmethane and/or 4,4'-diaminodiphenylmethane. In a particular embodiment, aromatic compounds which can be hydrogenated to the corresponding cycloaliphatic amines which conprise by-products are used in the process according to the invention. Examples of such by-products are hydrochlorides of the aromatic starting amines or higher-boiling aromatic by-products. Higher-boiling by-products refer to those constituents which rave a higher boiling point than the aromatic starting compounds which are to be hydrogenated to the cycloaliphatic products. The chlorine content of the aromatic compounds which can be hydrogenated to the corresponding cycloaliphatic amines is preferably 1 ppm or more, preferably from 10ppmto 10 000ppm and more preferably from 20 ppm to 1000 ppm, the chlorine content being determined typically to DIN V 51408 part 2. The content of higher-boiling aromatic compounds in the starting compounds is generally 1 % by weight and more, preferably from 2 to 20% by weight and more preferably from 2 to 10% by weight, the content of higher-boiling aromatic compounds being determined by laboratory distillation to A3TM D 5236-03 at a pressure of 1 mbar and a temperature up to 260°C. In the process according to the invention, a hydrogen-comprising gas is used. The hydrogen is generally used in technical-grade purity. The hydrogen can also be used in the form of a hydrogen-comprising gas, i.e. in admixtures with other inert gases, such as nitrogen, helium, neon, argon or carbon dioxide. The hydrogen-comprising gases used may, for example, be reformer offgases, refinery gases, etc., when and if these gases do not comprise any catalyst poisons fo the Ru catalysts, for example CO. However, preference is given to using pure hydrogen or essentially pure hydrogen in the process. The aromatic amines are prepared in the presence of Ru catalysts. In the process according to the invention for hydrogenating aromatic compounds, a heterogeneous Ru catalyst is general used. The Ru catalyst used in the process may have different morphologies. For instance, Ru catalysts may comprise support materials. The support materials used are typically carbon, such as graphite, carbon black and/or activated carbon, aluminum oxide, silicon dioxide, zirconium dioxide, zeolites, aluminosilicates, etc., and also mixtures of these support materials. Supported catalysts can be prepared by known processes, such as impregnation (described, for example, in A. B. Stiles, Catalyst Manufacture - Laboratory and Commercial Preparations, Marcel Dekker, Nev/York, 1983) or precipitation (described, for example in EP-A2-1106 600, page 4, and A. B. Stiles, Catalyst Manufacture, Marcel Dekker, Inc., 1983, page 15). The shape and size of the support material msy vary. Typical mean particle sizes of support materials are within the range from O.C 01 up to 5 millimeters, preferably from 0.0005 to 1 mm, more preferably from 0.001 tc 0.5 mm. The Ru catalyst can also be used without support material; for example, Ru can be used in the form of RuO2 or oxide hydrates of ruthenium. Typically, the mean particle size of heterogeneous Ru catalysts which have been obtained by precipitation is in the range from 1 nm to 1 urn, preferably in the range from 3 nm to 100 nm. For example, the mean particle size of the ruthenium particles which are used in the form of the oxide hydrates of Ru, according to the disclosure of DE-A-2132546, is between 4 and 6 nm. The heterogeneous Ru catalyst used is prefers bly a catalyst based on ruthenium oxide hydrate. Particular preference is given to using an Ru c;atalyst as disclosed in DE-A-2132547. The preparation of such preferred catalysts is described in detail, for example on pages 4 and 5 and in example 1 of DE-A-2132547. The Ru catalysts are typically used in suspended form. The process according to the invention is perfcrmed in the presence of inorganic additives. The specific surface area of the inorganic addiives, measured on the basis of ISO 5794-1, annex D, is typically in the range 1rom 10 to 1000 m2/g. Preference is given to substances which have a surface area in the range from 20 to 600 m2/g, more preferably in the range from 25 to 300 m2/g. The mean primary particle size of the inorganic: additives is generally in the range from 1 to 500 nm, preferably from 5 to 200 nm and more preferably from 5 to 100 nm, and is typically determined by means of electron microscopy, for example SEM. The particle size (d50) of the inorganic additives (laser diffraction based on ISO 13320-1) is typically from 1 to 200 urn. The tamped density of the inorganic additives measured on the basis of ISO 787-11) is typically in the range from 10 to 2000 g/l, preferably in the range from 50 to 1000 g/l and more preferably in the range from 50 to 500 g/l. The inorganic additives are used in suspendec form in the process according to the invention. The inorganic additives used in the process according to the invention may, for example, be inorganic additives selected from the group consisting of aluminum oxide, silicon dioxide, alkali metal, alkaline earth metcil and aluminum silicates, alkali metal, alkaline earth metal and aluminum borosilicates, titanium dioxide, metal soaps, zeolites, magnesium oxide, zinc oxide, zirconium oxide and inorganic carbon compounds. The inorganic additive used may be aluminum oxide, for example a-aluminum oxide or y-aluminum oxide. Particular preference is given to using y-aluminum oxide. The specific surface area of y-aluminum oxide is generally in the range from 150 to 400 m2/g (cf. Ullmanns Enzyklopadie der Techiischen Chemie, 4th edition, volume 7, p. 293 ff). The inorganic additive used may also be silicon dioxide. Examples of silicon dioxide which can be used in the process according to the invention are kieselguhr or particular forms of s ilicas (cf. Ullmanns Enzyklopadie der Technischen Chemie, 4th edition, volume 21, p. 439 ff). Kieselguhr refers typically to diatomaceous eatth (diatomite), which has formed from sedimented diatoms. Processed kieselguhr generally has a specific surface area of from 10to25m2/g. The silicas generally differ by the method of their production. Examples of silicas are fumed silicas, precipitated silicas and chemica ly aftertreated silicas. The term "fumed silicas" generally encompasses the high-dispersity silicas which are obtained from the gas phase by coagulation at high temperatures. Precipitated silicas are generally obtained by precipitation from an aqueous waterglass solution by means of acid (usually sulfuric acid), subsequent removal of the precipitate and the drying or spray-drying thereof. Chemically aftertreated silicas are typically understood to mean fumed silicas or precipitated silicas whose surface has been chemically modified by reaction, for example, with chlorosilanes or silicone acids. Eixamples of fumed or precipitated silicas are the "Sipernat® D17" and "Sipernat© 22" product types from Evonik-Degussa GmbH. According to the preparation process, the spec ific surface area of the silicas mentioned is in the range from 10 to 1000 m2/g. Their primary particle size is from approx. 5 to 500 nm. Typical silicas which can be used as additives have, for example, the following values: Specific Mean primary Tamped density surface area particle size ISO 787-11 m2/g nm g/l Fumed silicas 25-600 5-500 50-200 Precipitated silicas 30 -1000 3-100 50 -1000 Chem. aftertreated silicas approx. 110 approx. 28 approx. 80 The inorganic additives used may also be alka i metal, alkaline earth metal and aluminum silicates. It is possible here to use either naturally occurring or synthetic silicates. In particular, aluminum silicates include the clay minerals bentonite, fuller's earth, bole, umbra, alumina, montmorillonite, vermiculite of kaolin. These naturally occurring products in some cases comprise minor amou its of further metal constituents, for example iron (cf. Ullmanns Enzyklopadie der Technischen Chemie, 4th edition, volume 23, p. 311 ff.). It is also possible for calcium silicates or sodiu n aluminum silicates to find use as inorganic additives. The specific surface area of these silicates is generally from 20 to 200 m2/g. A preferred synthetic sodium aluminum silicate is especially the "Sipernat® 820A" type (from Evonik-Degussa GmbH) with a specific surface area of 85 m2/g and a d50 particle size of 7.5 urn. Inorganic additives also include alkali metal, alkaline earth metal and aluminum . borosilicates. In the borosilicates, the SiO4 tetrahedra which are the basis units of the silicates are partly replaced by BO4 tetrahedra Examples of borosilicates are tourmaline, alumina-tourmaline or magnesia-a umina-tourmaline. The values of the specific surface area and primary particle size are similar to the values as have been specified for the silicates. The inorganic additive used may also be titanium dioxide. Titanium dioxide may be present, for example, in the anatase or the rutile polymorph. Preference is given to using titanium dioxide in the anatase polymorph. The specific surface area of titanium dioxide is typically from approx. 30 to 70 m2/g, the primary particle size is generally between appiox. 20 and 40 nm, and the tamped density is generally in the range from 120 to 10 g/l. Metal soaps may likewise be used as inorganio additives in the process according to the invention. Examples of metal soaps are the aluminum, cadmium, lithium, calcium, magnesium or zinc salts of fatty acids such as myristic acid, palmitic acid or stearic acid. The particle size of the metal salts is generally less than 200 urn, preferably less than 100 urn. It is also possible to use naturally occurring or synthetic zeolites as inorganic additives in the process according to the invention. The specific surface area of the zeolites is in many cases 800 m2/g or higher. The size of th 3 synthetic zeolite particles is generally in the range from 1 to 100 urn. Further suitable additives include magnesium oxide, zinc oxide and zirconium oxide. The inorganic additives used in the process according to the invention may also be inorganic carbon compounds. Inorganic carbon compounds are, for example, activated carbons, carbon molecular sieves, and natural or synthetic carbon black. The specific surface area of these carbon compounds is, according to the type and production process, typically in the range of 800-1000 m2/g for activated carbons, generally Preference is given to using, as inorganic addi:ives, aluminum oxide, silicon dioxide, alkali metal, alkaline earth metal and aluminum silicates, alkali metal, alkaline earth metal and aluminum borosilicates, titanium dioxide, metal soaps, zeolites, magnesium oxide, zinc oxide, zirconium oxide or inorganic carbon compounds. Particular preference is given to using, as inorganic additives, silicon dioxide, alkali metal, alkaline earth metal and aluminum silicates, alkali metal, alkaline earth metal and aluminum borosilicates, titanium dioxide, metal soaps, zeolites, magnesium oxide, zinc oxide, zirconium oxide or inorganic carbon compounds. Very particular'preference is given to using, as inorganic additives, silicon dioxide, alkali metal, alkaline earth metal and aluminum silicates or alkali metal, alkaline earth metal and aluminum borosilicates. Special preference is given to using silicon dioxide in the process according to the invention. The additives mentioned are, as stated above, all known and for the most part commercially available. They typically find use as filtering aids, adsorption materials, as a support material for catalysts or as catalysts. According to the invention, the inorganic additives are added in an amount of from 1% by weight to 500% by weight, based on the ca alyst (calculated as elemental ruthenium). Preference is given to using from 5 to 200% by weight and especially from 20 to 120% by weight of inorganic additives, based in each case on the catalyst (calculated as elemental ruthenium). However it is also possible to use greater amounts of inorganic additives, though employment of very high amounts may cause blockages owing to the additives. The amount of the heterogeneous Ru catalysts used in the abovementioned processes is typically within a range of from 0.0005 to 5% by weight of ruthenium, calculated as the metal, based on the substance to be converted, especially on the starting substance to be hydrogenated. The amount of the Ru catalysts used is preferably in the range from 0.001 to 1 % by weight of ruthenium based on the substance to be converted, especially on the starting substance to be hydrogenated. The amount of the Ru catalysts used is more preferably in the rarge from 0.001 to 0.1 % by weight of ruthenium based on the substance to be conve rted. The hydrogenation can be carried out batchwise or continuously. In the batchwise reaction regime, the hydrogenation can be carried out, for example, in a stirred tank or stirred autoclave, a loop reactor, a jet loop reactor, a bubble column or a reactor with a pumped circulation system. Praference is given to performing the batchwise hydrogenation in a stirred tank or stirred autoclave. In the continuous reaction regime, the hydrogenation is typically performed in a continuous stirred tank reactor, a continuous loop reactor, a continuous jet loop reactor, a continuous bubble column or a continuous reactor with a pumped circulation system or a stirred tank cascade. The process according to the invention is performed at a pressure of 50-350 bar; preference is given to employing a pressure of from 150 to 250 bar. According to the invention, the process is performed at a temperature in the range between 30 and 280°C, particular preference being given to the temperature range from120to260°C. The hydrogenation can be carried out with or v/ithout solvent. The solvents used are alcohols such as isopropanol, isobutanol or t-butanol, or ethers such as diethyl ether, glycol dimethyl ether, dioxane or tetrahydrofuran. However, the solvent used may also be the end product formed in the reaction. Useful solvents also include mixtures of the aforementioned solvents. Preferred solvents are isopropanol, isobutanol and/or t-butanol. Particular preference is given to using, as the solvent, the end product formed in the reaction. The solvent is usually employed in such an arrount as to obtain from 10 to 50% (% by weight), preferably from 15 to 40% and more preferably from 20 to 30% solutions of the aromatic compounds intended for hydrogenation. It is particularly advantageous for the continuous performance of the process to employ the end product formed in the reaction as the solvent. The Ru catalyst and the inorganic additive are used in the form of a suspension of the catalyst and of the additive in the liquid reactants and/or solvents used. In batchwise mode, the Ru catalyst is typically, either in the form of dry powder or in the form of water-moist filtercake, added directly to the hydrogenation reactor together with the inorganic additive. Particularly advantageously, the Ru catalyst together with the inorganic additive is mixed with a solvent, the liquid feedstock or liquid reaction effluent to give a suspension which can then be fed to the reactor by means of suitable metering pumps. In continuous mode, this catalyst suspension is typically fed continuously to the hydrogenation reactor. Some inorganic additives, for example kieselguhr or precipitated silicas, may also already be present in the course of precipitation of the Ru(IV) oxide hydrate particles, i.e. they can be added to the particular aqueous ruthenium salt solution before precipitation of the ruthenium oxide hydrate. They are then added to the reaction mixture directly together with the catalyst. The reaction mixture from the hydrogenation is typically purified. The reaction mixture is typically purified by rectification or distillation. The inorganic additive and the heterogeneous Ru catalyst can be removed before the distillation, for example by a solid-liquid separation, such as filtration, sedimentation or centrifugation. Solvents and unconverted starting materials can be recycled into the process. The cycloaliphatic amines obtainable by the process according to the invention can be used as a synthesis unit for the preparation of surfactants, pharmaceutical and crop protection compositions, stabilizers including light stabilizers, polymers, isocyanates, hardeners for epoxy resins, catalysts for polyu'ethanes, intermediates for preparing quaternary ammonium compounds, plasticizers, corrosion inhibitors, synthetic resins, ion exchangers, textile assistants, dyes, vulcanization accelerants, emulsifiers and/or as starting substances for the preparation of u eas and polyureas. In particular, it is possible to use cyclohexylamine obtainable by the hydrogenation of aniline as a corrosion inhibitor or vulcanization accelerant. 4,4'-diaminodiphenyl-methane, 4,4'-diamino-3,3,,5,5,-tetramethyldiphenylmethane or 4,4'-diamino-3,3'-dimethyldiphenylmethane can be used as a monomer unit for polyamides, as a hardener for epoxy resins or as a starting material for the preparation of the corresponding isocyanates. The advantages of the process according to the invention are that the process according to the invention generally has a high space time yield. In addition, the process typically ensures stable operation, since problems which occur as a result of agglomeration of catalyst particles and the resulting blockages are reduced. The reduced sedimentation tendency of the catalyst particles generally ensures that essentially the entire amount of catalyst used is available to the reaction mixture and a portion of the catalyst is not removed by sediments. In addition, the process according to the invention can increase the yield of product and reduce the formation of by-products, especially when starting materials which comprise a certain level of troublesome by-products are used. The process is therefore generally suitable particularly for the hydrogenation of aromatic starting materials which comprise by-products such as hydrochlorides of the aromatic starting amines or higher-boiling impurities. The process according to the invention is therefore also generally suitable for starting materials which have a chlorine content of 1 ppm and more, or a proportion of higher-boiling products which is 1% by weight or more. The process according to the invention is illustated in detail by the examples which follow. Examples 1 to 4 Examples 1 to 4 show the advantages of the present invention when using a chlorinated starting compound. Examples 1 to 4 were each carried out under the same reaction conditions. In example 1, no inorganic additive was addec. In examples 2 to 4, in each case 5% by weight, based on the catalyst (calculated as elemental ruthenium) of inorganic additives was added. These were the following components: example 2: calcium stearate metal soap (particle size example 3: hydrophilic colloidal precipitated silica - spray-dried (spec, surface area approx. 190 m2/g, mean primary particle size approx. 18 nm, particle size to ISO 13320-1: 30 to 200 urn) (Sipernat® 22 from Evonik-Degussa GmbH) example 4: hydrophobic, colloidal, chemically .aftertreated silica (spec, surface area approx. 110 m2/g, mean primary particle size approx. 28 nm) (Sipernat® D17 from Evonik-Degussa GmbH) Procedure: Experiments 1-4 A roll autoclave with a glass insert was initially charged with 250 parts by weight of bis(4-amino-3-rnethylphenyl)methane, 2.5 parls by weight of catalyst suspension and if appropriate the particular amount of inorganic additive (examples 2 to 4). The catalyst suspension comprised 2% by weight, based on the suspension, of ruthenium catalyst (calculated as elemental ruthenium) and 0.134 % by weight, based on the suspension, of bis(4-amino-3-methylphenyl)methane hydrochloride. The autoclave was first flushed with gaseous nitrogen, then hydrogen was injected in the cold state until a pressure of 100 bar was established. Then the rolling operation was begun and the temperature was simultaneously increased from room temperature to 230°C within 4 hours. Additional hydrogen was then injected until a pressure of 270 bar was established. The roll autoclave was then operated at a temperature of 230°C for 5 hours, in the course of which additional hydrogen was injected at hourly intervals in order to maintain the pressure of 270 bar. Thereafter, the pressure was adjusted once again to 270 bar of hydrogen and both the rolling drive and the heating were switched off. Once the reaction mixture had reached room temperature, the autoclave was decompressed, and the reaction mixture was removed and the catalyst and inorganic additive were filtered off. The filtrate was then subjected to a fractional cistillation under reduced pressure. The results obtained in each case are reproduced below (concentration data in % by weight): Low-boiling by-products End product Intermediate Starting material High-boiling by-products Example 1 Example 2 {comparative, Calcium without stearate additive) 1.71 2.33 47.19 68.7 41.86 19/6 0.24 0.16 9.0 9.(i Example 3 Example 4 Si02 Si02 (hydrophilic) (hydrophobic) 2.46 75.14 12.99 0 9.4 3.0 71.58 16.82 0 8.6 End product: bis(4-amino-3-methylcyclohexyl)methane Intermediate: (4"amino-3-methylcyclohexyl)(4-,amino-3-methylphenyl)methane Starting material: bis(4-amino-3-methylphenyl)methane In examples 2 to 4, significantly higher conversions were achieved compared to example 1. Example 5: Example 5 demonstrates a continuous hydrogenation by the process according to the invention. The preparation of the Ru(IV) oxide hydrate was carried out according to example 1 in DE 21 32 547, with the only exception that the final drying under reduced pressure was omitted. To prepare the catalyst suspension, 5 500 g of the filtercake thus prepared (with 579 g of Ru, calculated 100%) and 280 g of hydrophobic SiO2 (Sipernat D17® from Evonik-Degussa GmbH) were added to a stirred vessel and mixed intensively with 150 kg of a liquid product mixture (output of the hydrogenation reactor), such that the suspension obtained comprised 0.37% by weight of Ru. The performance of the hydrogenation was pe •formed in a continuous production plant with a cooled high-pressure bubble column reactor. 500 kg/h of a liquid melt of bis(4-aminophenyl)methane and 6.7 kg/h of the catalyst suspension were fed continuously into this reactor. The pressure in he reactor was regulated to 200 bar by replenishing pure hydrogen. The temperature in the reactor was kept constant within the range from 230 to 240°C by cooling. The product mixture exiting from the reactor was decompressed and cooled to a temperature of 100°C. The analysis of the prociuct mixture by means of gas chromatography gave the following values (concentration data in % by weight): Reaction output analysis Low-boiling by-products High-boiling by-products End product Intermediate Starting material % by weight 7.85 2 90 0.1 0.05 End product: bis(4-aminocyclohexy!)methane Intermediate: (4-aminocyclohexyl)(4-aminopheiyl)methane Starting material: bis(4-aminophenyl)methane The hydrogenation was conducted over a period of four weeks under constant conditions without any decline in the reactivity or else a blockage of the reactor as a result of solid sedimentation being observed. Without addition of the inorganic additives, sediments which disrupt production and lead to a decrease in the yield and selectivity generally occur after only one week. Claims 1. A process for preparing cycloaiiphatic amines by hydrogenating the corresponding aromatic compounds with hydrogen-comprising gas at a temperature of from 30 to 280°C and a pressure of 50 - 350 bar, in the presence of ruthenium catalysts, which comprises performing the hydrogenation in the presence of from 1% by weight to 500% by weight, based on the catalyst (calculated as elemental ruthenium (Ru) , of suspended inorganic additives. 2. The process according to claim 1, wherein the inorganic additives used are substances selected from the group consisting of aluminum oxide, silicon dioxide, alkali metal, alkaline earth meta and aluminum silicates, alkali metal, alkaline earth metal and aluminum borosilicates, titanium dioxide, metal soaps, zeolites, magnesium oxide, zinc oxide, 2irconium oxide and inorganic carbon compounds. 3. The process according to at least one o1 claims 1 to 2, wherein the inorganic additives have a specific surface area o1 from 10 to 1000 m2/g. 4. The process according to at least one oi claims 1 to 3, wherein the inorganic additives have a mean primary particle size of from 1 to 500 nm. 5. The process according to at least one o1 claims 1 to 4, wherein the inorganic additives used are hydrophobic silicates. 6. The process according to at least one o: claims 1 to 5, wherein the aromatic compounds used are mono- or polycycl c aromatic amines. 7. The process according to at least one o: claims 1 to 6, wherein the hydrogenation is performed in continuous mode. 8. The process according to at least one of claims 1 to 7, wherein the hydrogenation is performed in the presence of a solvent. 9. The process according to at least one of claims 1 to 8, wherein the end product formed in the reaction is used as the so vent. 10. The process according to at least one of claims 1 to 9, wherein the hydrogenation is performed in the presence of an Ru catalyst whose precursor is ruthenium oxide hydrate. 11. The process according to at least one of claims 1 to 10, wherein the hydrogenation is performed in the preserce of from 5% by weight to 200% by weight, based on the catalyst (calculated as elemental ruthenium) of suspended inorganic additives. 12. The process according to at least one of claims 1 to 11, wherein the aromatic starting compounds used in the process lave a chlorine content of 1 ppm or more and/or a content of higher-boiling aromatic by-products of 1 % by weight or more. 13. The process according to at least one of claims 1 to 12, wherein the aromatic compound used is polymeric MDA, anilire, 4,4'-diamino-3,3'-dimethyldiphenyl-methane, 4,4'-diamino-3,3,,5,5'-tetramethyldiphenylmethane and/or 4,4'-diamtnodiphenylmethane. 14. The use of cycloaliphatic amines obtainable according to at least one of claims 1 to 13 as a synthesis unit for the preparat on of surfactants, pharmaceutical and crop protection compositions, stabilizers including light stabilizers, polymers, isocyanates, hardeners for epoxy resins, catalysts for polyurethanes, intermediates for preparing quaternary ammonium compounds, plasticizers, corrosion inhibitors, synthetic resins, ion exchangers, textile assistants, dyes, vulcanization accelerants, emulsifiers and/or as starting substances for the preparation of ureas and polyureas. 15. The use of cyclohexylamine obtainable ciccording to claim 13, as a corrosion inhibitor or vulcanization accelerant. 16. The use of 4,4'-diaminodiphenylmethane!, 4,4'-diamino-3,3',5,5'-tetramethyl-diphenylmethane or 4,4'-diamino-3,3'-dirnethyldiphenylmethane obtainable according to claim 13 as a monomer unin for polyamides, as a hardener for epoxy resins or as a starting material for the preparation of the corresponding isocyanates.

Full Text

FORM 2
THE PATENTS ACT, 1970
(39 of 1970)
&
THE PATENTS R ULES, 2003
COMPLETE SPECIFICATION (See section 10, rule 13)
"METHOD FOR THE PRODUCTION OF CYCLOALIPHATIC AMINES"
BASF SE, a German company, of 67056 Ludwigshafen, Germany;
The following specification particularly describes the invention and the manner in which it is to be performed.

Method for the production of cycloaliphatic amines
Description
The present invention relates to a process for preparing cycloaliphatic amines by hydrogenating the corresponding aromatic compounds in the presence of ruthenium (Ru)-comprising catalysts, in the presence of sjspended inorganic additives. The present invention further relates to the use of the cycloaliphatic amines thus obtainable.
US 2,606,925 describes the hydrogenation of aromatic compounds which are substituted directly on the aromatic ring via nitrsgen atoms (for example aromatic amines or nitro compounds) to the corresponding cycloaliphatic compounds. The catalysts used are elemental ruthenium metal, ruthenium oxides, ruthenium salts, ruthenium sulfides and ruthenium sulfates. Optimal results can be achieved according to this document when the ruthenium is present in finely distributed form. However, no method of preparing these catalysts is described.
In US 2,494,563, finely divided Ru catalysts aro used for the hydrogenation of aromatic diamines to the corresponding aliphatic diamines.
A method for preparing very small ruthenium dioxide particles by reacting RuCb solution with NaOH in the aqueous phase, wasning and drying is described in CA-A-860855. This affords crystal sizes less than 50 nm. A preferred use specified for the powder obtained was the production of electrical resistors.
DE-A-2132547 discloses a process for hydrogenating aromatic compounds to the corresponding cycloaliphatic. For the hydrogenation, a catalyst based on oxide hydrates of Ru is used. The catalyst is prepared by precipitation from an aqueous solution of a ruthenium salt by addition of alkali metal hydroxide solution. The ruthenium oxide hydrate thus obtained can be used directly in the process or be subjected to drying before use. After the drying, the catalyst, according to the disclosure, is present in the form of powder with particle sizes in the range from 4 to 6 nm, the Ru being present in the resulting dry powder as Ru(IV) oxide hydrate with approx. 50% by weight of Ru.
DE 101 19 135 A1 describes the continuous preparation of bis(4-aminocyclohexyl)-methane by hydrogenation of bis(4-aminophenyl)methane with the aid of a pulverulent ruthenium catalyst. The ruthenium was used applied to an inert support material, e.g. Al2O3, and with a particle size of 5-150 urn.
US 5,214,212 teaches the addition of metal salts as promoters in a process for hydrogenating aromatic amines. According to the disclosure, the addition of promoters

leads to an improvement in the reaction rate ard to a reduction in by-product formation. The metal salts were used in concentrations of from 0.3% to 10% based on the aromatic amine.
US 3,864,361 describes the preparation of 2,5-dimethylpyrrolidone by reduction of 2,5-dimethylpyrrole in the presence of finely divided, unsupported RuC>2. After the hydrogenation has ended, the catalyst is removed by filtration. According to the disclosure, the removal of the Ru catalyst can tie improved by the addition of AI2O3 as a filtering aid.
The prior art teaches the use of heterogeneous Ru catalysts with small particle sizes,
which should be present in very fine distribution in the reaction mixture. When such
catalysts are used in an industrial scale process, however, it is found that the small
catalyst particles form relatively large agglomerates during the hydrogenation, which
can then settle out in the reactor. This firstly removes a portion of the amount of
catalyst from the process; secondly, the resulting deposits can cause blockages which
lead to disruption in the course of operation.
In the aromatic starting materials which are used in the process for preparing cycloaliphatic amines, there are typically small amounts of by-products which generally cannot be removed quantitatively during the purification of the starting materials. These by-products can poison the ruthenium catalyst and hence reduce the space-time yield of the process.
In the case of the hydrogenation of bis(4-amincphenyl)methane or bis(4-amino-3-methylphenyl)methane to the particular cycknexyl derivatives, these by-products are principally the hydrochlorides of the aromatic starting amines and higher-boiling aromatic products.
Even when the chlorine content of the particula - starting materials is higher than 1 ppm or the concentration of higher-boiling products exceeds the value of 2% by weight, considerable losses in the space-time yield can arise.
It was therefore an object of the present inventi :>n to provide a process for preparing cycloaliphatic compounds which has a high spece-time yield. In addition, the intention was to develop a process which ensures stable industrial scale operation and reduces the problems which occur through agglomeration of catalyst particles and the resulting blockages. Furthermore, with the aid of the process according to the invention, the yield of product shall be increased and the forrration of by-products reduced, especially in the case of use of starting materials which ccmprise a certain degree of troublesome by-products. Thus, the intention was to ensure stable production operation overall, and a high yield and selectivity.

According to the invention, the object is achieved by a process for preparing cycloaliphatic amines by hydrogenating the corresponding aromatic compounds with hydrogen-comprising gas at a temperature of from 30 to 280°C and a pressure of 50 -350 bar, in the presence of ruthenium catalysts, which comprises performing the hydrogenation in the presence of from 1 % by weight to 500% by weight, based on the catalyst (calculated as elemental ruthenium), of suspended inorganic additives.
In the process according to the invention, arorratic compounds which can be hydrogenated to cycloaliphatic amines are used.
Aromatic compounds which can be hydrogena:ed to cycloaliphatic amines are typically mono- or polycyclic aromatic compounds which comprise one or more nitrogen-containing substituents.
In a preferred embodiment, aromatic compounds with one or more nitrogen-containing substituents are used, in which the nitrogen atom of the nitrogen-containing substituent is bonded directly on the aromatic ring (N-substituted aromatic compounds). '
Preference is given to using aromatic mono-, c i- or polyamines which can be hydrogenated to the corresponding cycloaliphcitic amines.
Useful aromatic amines include mono- or polycyclic aromatic compounds with one or more amine groups, for example:
aromatic monoamines such as aniline, the isomeric toluidines, the isomeric xylidines, 1- or 2-aminonaphthalene, benzidine and substituted benzidines;
aromatic diamines such as the isomeric phenylenediamines, the isomeric tolylenediamines, the isomeric diaminonaphthalenes, 4,4'-diamino-3,3'-dimethyldiphenylmethane, 4,4'-diamino-3,B'.S.S'-tetramethyldiphenylmethane and 4,4'-diaminodiphenylmethane; or
aromatic polyamines such as polymeric MDA (polymethylenepolyphenylamine).
The aromatic compounds which can be hydrogenated to cycloaliphatic amines and
which are used may also be aromatics with nit*o, nitrile and urethane groups as
substituents on the aromatic ring,
for example
aromatic compounds with nitro groups as substituents, such as nitrobenzene,
nitrotoluene, dinitrobenzene, dinitrotoluene and the isomeric nitroanilines;

aromatic compounds with nitrile groups as substituents, such as benzonitrile, tolunitrile or o-aminobenzonitrile; or
aromatic compounds with urethane groups as substituents, such as the
dialkylurethanes which are formed from diphenylmethane 4,4'-diisocyanate,
diphenylmethane 2,4'-diisocyanate or diphenylmethane 2,2'-diisocyanate, and aliphatic
alcohols such as Ci-Ce-alcohols, especially n-tutanol,
the dialkylurethanes which are formed from tolylene 2,4-diisocyanate or tolylene
2,6-diisocyanate, and aliphatic alcohols such as C1-C6-alcohols, especially n-butanol,
the dialkylurethanes which are formed from polymeric diphenylmethane diisocyanate
and aliphatic alcohols such as C1-C6-alcohols, especially n-butanol,
the dialkylurethanes which are formed from phenylene 2,4-diisocyanate or phenylene
2,6-diisocyanate, and aliphatic alcohols such as C1-C6-alcohols, especially n-butanol,
or
the dialkylurethanes which are formed from naphthylene 1,5-diisocyanate and aliphatic
alcohols such as Ci-Ce-alcohols, especially n-butanol.
In addition to the substituents which can be hydrogenated to amine groups, the aromatic compounds may have no further substituents or they may bear one or more further substituents, for example alkyl, cycloalkyl, aryl, heteroaryl, halogen, haloalkyl, silyl, hydroxyl, alkoxy, aryloxy, carboxyl or alkoxycarbonyl substituents.
Preference is given to using, in the process, anmatic amines such as the aforementioned aromatic mono-, di- and/or pol/amines.
Particular preference is given to using polymer c MDA, aniline, 2,4-diaminotoluene,
2,6-diaminotoluene, o-phenylenediamine, m-phenylenediamine, p-phenylenediamine,
4,4'-diamino-3,3'-dimethyldiphenylrnethane, 4,4,-diamino-3,3',5,5,-tetramethyldiphenyl-
methane and/or 4,4'-diaminodiphenylmethane in the process.
Very particular preference is given to using aniiine, 4,4'-diamino-3,3'-dimethyldiphenyl-
methane, 4,4'-diamino-3,3',5,5'-tetramethyldiphenylmethane and/or
4,4'-diaminodiphenylmethane.
In a particular embodiment, aromatic compounds which can be hydrogenated to the corresponding cycloaliphatic amines which conprise by-products are used in the process according to the invention. Examples of such by-products are hydrochlorides of the aromatic starting amines or higher-boiling aromatic by-products. Higher-boiling by-products refer to those constituents which rave a higher boiling point than the aromatic starting compounds which are to be hydrogenated to the cycloaliphatic products.
The chlorine content of the aromatic compounds which can be hydrogenated to the corresponding cycloaliphatic amines is preferably 1 ppm or more, preferably from

10ppmto 10 000ppm and more preferably from 20 ppm to 1000 ppm, the chlorine content being determined typically to DIN V 51408 part 2. The content of higher-boiling aromatic compounds in the starting compounds is generally 1 % by weight and more, preferably from 2 to 20% by weight and more preferably from 2 to 10% by weight, the content of higher-boiling aromatic compounds being determined by laboratory distillation to A3TM D 5236-03 at a pressure of 1 mbar and a temperature up to 260°C.
In the process according to the invention, a hydrogen-comprising gas is used. The hydrogen is generally used in technical-grade purity. The hydrogen can also be used in the form of a hydrogen-comprising gas, i.e. in admixtures with other inert gases, such as nitrogen, helium, neon, argon or carbon dioxide. The hydrogen-comprising gases used may, for example, be reformer offgases, refinery gases, etc., when and if these gases do not comprise any catalyst poisons fo the Ru catalysts, for example CO. However, preference is given to using pure hydrogen or essentially pure hydrogen in the process.
The aromatic amines are prepared in the presence of Ru catalysts.
In the process according to the invention for hydrogenating aromatic compounds, a heterogeneous Ru catalyst is general used.
The Ru catalyst used in the process may have different morphologies.
For instance, Ru catalysts may comprise support materials.
The support materials used are typically carbon, such as graphite, carbon black and/or
activated carbon, aluminum oxide, silicon dioxide, zirconium dioxide, zeolites,
aluminosilicates, etc., and also mixtures of these support materials.
Supported catalysts can be prepared by known processes, such as impregnation
(described, for example, in A. B. Stiles, Catalyst Manufacture - Laboratory and
Commercial Preparations, Marcel Dekker, Nev/York, 1983) or precipitation (described,
for example in EP-A2-1106 600, page 4, and A. B. Stiles, Catalyst Manufacture, Marcel
Dekker, Inc., 1983, page 15).
The shape and size of the support material msy vary. Typical mean particle sizes of
support materials are within the range from O.C 01 up to 5 millimeters, preferably from
0.0005 to 1 mm, more preferably from 0.001 tc 0.5 mm.
The Ru catalyst can also be used without support material; for example, Ru can be
used in the form of RuO2 or oxide hydrates of ruthenium. Typically, the mean particle
size of heterogeneous Ru catalysts which have been obtained by precipitation is in the
range from 1 nm to 1 urn, preferably in the range from 3 nm to 100 nm. For example,
the mean particle size of the ruthenium particles which are used in the form of the
oxide hydrates of Ru, according to the disclosure of DE-A-2132546, is between 4 and
6 nm.

The heterogeneous Ru catalyst used is prefers bly a catalyst based on ruthenium oxide
hydrate.
Particular preference is given to using an Ru c;atalyst as disclosed in DE-A-2132547.
The preparation of such preferred catalysts is described in detail, for example on
pages 4 and 5 and in example 1 of DE-A-2132547.
The Ru catalysts are typically used in suspended form.
The process according to the invention is perfcrmed in the presence of inorganic additives.
The specific surface area of the inorganic addiives, measured on the basis of ISO 5794-1, annex D, is typically in the range 1rom 10 to 1000 m2/g. Preference is given to substances which have a surface area in the range from 20 to 600 m2/g, more preferably in the range from 25 to 300 m2/g.
The mean primary particle size of the inorganic: additives is generally in the range from 1 to 500 nm, preferably from 5 to 200 nm and more preferably from 5 to 100 nm, and is typically determined by means of electron microscopy, for example SEM.
The particle size (d50) of the inorganic additives (laser diffraction based on ISO 13320-1) is typically from 1 to 200 urn.
The tamped density of the inorganic additives measured on the basis of ISO 787-11) is typically in the range from 10 to 2000 g/l, preferably in the range from 50 to 1000 g/l and more preferably in the range from 50 to 500 g/l.
The inorganic additives are used in suspendec form in the process according to the invention.
The inorganic additives used in the process according to the invention may, for example, be inorganic additives selected from the group consisting of aluminum oxide, silicon dioxide, alkali metal, alkaline earth metcil and aluminum silicates, alkali metal, alkaline earth metal and aluminum borosilicates, titanium dioxide, metal soaps, zeolites, magnesium oxide, zinc oxide, zirconium oxide and inorganic carbon compounds.
The inorganic additive used may be aluminum oxide, for example a-aluminum oxide or y-aluminum oxide. Particular preference is given to using y-aluminum oxide.
The specific surface area of y-aluminum oxide is generally in the range from 150 to 400 m2/g (cf. Ullmanns Enzyklopadie der Techiischen Chemie, 4th edition, volume 7,

p. 293 ff).
The inorganic additive used may also be silicon dioxide.
Examples of silicon dioxide which can be used in the process according to the invention are kieselguhr or particular forms of s ilicas (cf. Ullmanns Enzyklopadie der Technischen Chemie, 4th edition, volume 21, p. 439 ff).
Kieselguhr refers typically to diatomaceous eatth (diatomite), which has formed from sedimented diatoms. Processed kieselguhr generally has a specific surface area of from 10to25m2/g.
The silicas generally differ by the method of their production. Examples of silicas are fumed silicas, precipitated silicas and chemica ly aftertreated silicas.
The term "fumed silicas" generally encompasses the high-dispersity silicas which are obtained from the gas phase by coagulation at high temperatures.
Precipitated silicas are generally obtained by precipitation from an aqueous waterglass solution by means of acid (usually sulfuric acid), subsequent removal of the precipitate and the drying or spray-drying thereof.
Chemically aftertreated silicas are typically understood to mean fumed silicas or precipitated silicas whose surface has been chemically modified by reaction, for example, with chlorosilanes or silicone acids. Eixamples of fumed or precipitated silicas are the "Sipernat® D17" and "Sipernat© 22" product types from Evonik-Degussa GmbH.
According to the preparation process, the spec ific surface area of the silicas mentioned is in the range from 10 to 1000 m2/g. Their primary particle size is from approx. 5 to 500 nm. Typical silicas which can be used as additives have, for example, the following values:
Specific Mean primary Tamped density
surface area particle size ISO 787-11
m2/g nm g/l
Fumed silicas 25-600 5-500 50-200
Precipitated silicas 30 -1000 3-100 50 -1000
Chem. aftertreated silicas approx. 110 approx. 28 approx. 80
The inorganic additives used may also be alka i metal, alkaline earth metal and aluminum silicates. It is possible here to use either naturally occurring or synthetic

silicates.
In particular, aluminum silicates include the clay minerals bentonite, fuller's earth, bole, umbra, alumina, montmorillonite, vermiculite of kaolin. These naturally occurring products in some cases comprise minor amou its of further metal constituents, for example iron (cf. Ullmanns Enzyklopadie der Technischen Chemie, 4th edition, volume 23, p. 311 ff.).
It is also possible for calcium silicates or sodiu n aluminum silicates to find use as inorganic additives. The specific surface area of these silicates is generally from 20 to 200 m2/g. A preferred synthetic sodium aluminum silicate is especially the "Sipernat® 820A" type (from Evonik-Degussa GmbH) with a specific surface area of 85 m2/g and a d50 particle size of 7.5 urn.
Inorganic additives also include alkali metal, alkaline earth metal and aluminum . borosilicates. In the borosilicates, the SiO4 tetrahedra which are the basis units of the silicates are partly replaced by BO4 tetrahedra Examples of borosilicates are tourmaline, alumina-tourmaline or magnesia-a umina-tourmaline. The values of the specific surface area and primary particle size are similar to the values as have been specified for the silicates.
The inorganic additive used may also be titanium dioxide. Titanium dioxide may be present, for example, in the anatase or the rutile polymorph. Preference is given to using titanium dioxide in the anatase polymorph.
The specific surface area of titanium dioxide is typically from approx. 30 to 70 m2/g, the primary particle size is generally between appiox. 20 and 40 nm, and the tamped density is generally in the range from 120 to 10 g/l.
Metal soaps may likewise be used as inorganio additives in the process according to the invention.
Examples of metal soaps are the aluminum, cadmium, lithium, calcium, magnesium or zinc salts of fatty acids such as myristic acid, palmitic acid or stearic acid. The particle size of the metal salts is generally less than 200 urn, preferably less than 100 urn.
It is also possible to use naturally occurring or synthetic zeolites as inorganic additives in the process according to the invention. The specific surface area of the zeolites is in many cases 800 m2/g or higher. The size of th 3 synthetic zeolite particles is generally in the range from 1 to 100 urn.
Further suitable additives include magnesium oxide, zinc oxide and zirconium oxide.
The inorganic additives used in the process according to the invention may also be

inorganic carbon compounds. Inorganic carbon compounds are, for example, activated carbons, carbon molecular sieves, and natural or synthetic carbon black. The specific surface area of these carbon compounds is, according to the type and production process, typically in the range of 800-1000 m2/g for activated carbons, generally Preference is given to using, as inorganic addi:ives, aluminum oxide, silicon dioxide, alkali metal, alkaline earth metal and aluminum silicates, alkali metal, alkaline earth metal and aluminum borosilicates, titanium dioxide, metal soaps, zeolites, magnesium oxide, zinc oxide, zirconium oxide or inorganic carbon compounds.
Particular preference is given to using, as inorganic additives, silicon dioxide, alkali metal, alkaline earth metal and aluminum silicates, alkali metal, alkaline earth metal and aluminum borosilicates, titanium dioxide, metal soaps, zeolites, magnesium oxide, zinc oxide, zirconium oxide or inorganic carbon compounds.
Very particular'preference is given to using, as inorganic additives, silicon dioxide, alkali metal, alkaline earth metal and aluminum silicates or alkali metal, alkaline earth metal and aluminum borosilicates.
Special preference is given to using silicon dioxide in the process according to the invention.
The additives mentioned are, as stated above, all known and for the most part commercially available. They typically find use as filtering aids, adsorption materials, as a support material for catalysts or as catalysts.
According to the invention, the inorganic additives are added in an amount of from 1% by weight to 500% by weight, based on the ca alyst (calculated as elemental ruthenium). Preference is given to using from 5 to 200% by weight and especially from 20 to 120% by weight of inorganic additives, based in each case on the catalyst (calculated as elemental ruthenium). However it is also possible to use greater amounts of inorganic additives, though employment of very high amounts may cause blockages owing to the additives.
The amount of the heterogeneous Ru catalysts used in the abovementioned processes is typically within a range of from 0.0005 to 5% by weight of ruthenium, calculated as the metal, based on the substance to be converted, especially on the starting substance to be hydrogenated. The amount of the Ru catalysts used is preferably in the range from 0.001 to 1 % by weight of ruthenium based on the substance to be converted, especially on the starting substance to be hydrogenated. The amount of the Ru catalysts used is more preferably in the rarge from 0.001 to 0.1 % by weight of

ruthenium based on the substance to be conve rted.
The hydrogenation can be carried out batchwise or continuously.
In the batchwise reaction regime, the hydrogenation can be carried out, for example, in a stirred tank or stirred autoclave, a loop reactor, a jet loop reactor, a bubble column or a reactor with a pumped circulation system. Praference is given to performing the batchwise hydrogenation in a stirred tank or stirred autoclave.
In the continuous reaction regime, the hydrogenation is typically performed in a continuous stirred tank reactor, a continuous loop reactor, a continuous jet loop reactor, a continuous bubble column or a continuous reactor with a pumped circulation system or a stirred tank cascade.
The process according to the invention is performed at a pressure of 50-350 bar; preference is given to employing a pressure of from 150 to 250 bar.
According to the invention, the process is performed at a temperature in the range between 30 and 280°C, particular preference being given to the temperature range from120to260°C.
The hydrogenation can be carried out with or v/ithout solvent. The solvents used are alcohols such as isopropanol, isobutanol or t-butanol, or ethers such as diethyl ether, glycol dimethyl ether, dioxane or tetrahydrofuran.
However, the solvent used may also be the end product formed in the reaction.
Useful solvents also include mixtures of the aforementioned solvents.
Preferred solvents are isopropanol, isobutanol and/or t-butanol. Particular preference is given to using, as the solvent, the end product formed in the reaction.
The solvent is usually employed in such an arrount as to obtain from 10 to 50% (% by weight), preferably from 15 to 40% and more preferably from 20 to 30% solutions of the aromatic compounds intended for hydrogenation.
It is particularly advantageous for the continuous performance of the process to employ the end product formed in the reaction as the solvent.
The Ru catalyst and the inorganic additive are used in the form of a suspension of the catalyst and of the additive in the liquid reactants and/or solvents used.

In batchwise mode, the Ru catalyst is typically, either in the form of dry powder or in the form of water-moist filtercake, added directly to the hydrogenation reactor together with the inorganic additive.
Particularly advantageously, the Ru catalyst together with the inorganic additive is mixed with a solvent, the liquid feedstock or liquid reaction effluent to give a suspension which can then be fed to the reactor by means of suitable metering pumps. In continuous mode, this catalyst suspension is typically fed continuously to the hydrogenation reactor.
Some inorganic additives, for example kieselguhr or precipitated silicas, may also already be present in the course of precipitation of the Ru(IV) oxide hydrate particles, i.e. they can be added to the particular aqueous ruthenium salt solution before precipitation of the ruthenium oxide hydrate. They are then added to the reaction mixture directly together with the catalyst.
The reaction mixture from the hydrogenation is typically purified.
The reaction mixture is typically purified by rectification or distillation.
The inorganic additive and the heterogeneous Ru catalyst can be removed before the
distillation, for example by a solid-liquid separation, such as filtration, sedimentation or
centrifugation.
Solvents and unconverted starting materials can be recycled into the process.
The cycloaliphatic amines obtainable by the process according to the invention can be used as a synthesis unit for the preparation of surfactants, pharmaceutical and crop protection compositions, stabilizers including light stabilizers, polymers, isocyanates, hardeners for epoxy resins, catalysts for polyu'ethanes, intermediates for preparing quaternary ammonium compounds, plasticizers, corrosion inhibitors, synthetic resins, ion exchangers, textile assistants, dyes, vulcanization accelerants, emulsifiers and/or as starting substances for the preparation of u eas and polyureas. In particular, it is possible to use cyclohexylamine obtainable by the hydrogenation of aniline as a corrosion inhibitor or vulcanization accelerant. 4,4'-diaminodiphenyl-methane, 4,4'-diamino-3,3,,5,5,-tetramethyldiphenylmethane or 4,4'-diamino-3,3'-dimethyldiphenylmethane can be used as a monomer unit for polyamides, as a hardener for epoxy resins or as a starting material for the preparation of the corresponding isocyanates.
The advantages of the process according to the invention are that the process according to the invention generally has a high space time yield. In addition, the process typically ensures stable operation, since problems which occur as a result of agglomeration of catalyst particles and the resulting blockages are reduced. The reduced sedimentation tendency of the catalyst particles generally ensures that essentially the entire amount of catalyst used is available to the reaction mixture and a

portion of the catalyst is not removed by sediments.
In addition, the process according to the invention can increase the yield of product and reduce the formation of by-products, especially when starting materials which comprise a certain level of troublesome by-products are used. The process is therefore generally suitable particularly for the hydrogenation of aromatic starting materials which comprise by-products such as hydrochlorides of the aromatic starting amines or higher-boiling impurities.
The process according to the invention is therefore also generally suitable for starting materials which have a chlorine content of 1 ppm and more, or a proportion of higher-boiling products which is 1% by weight or more.
The process according to the invention is illustated in detail by the examples which follow.
Examples 1 to 4
Examples 1 to 4 show the advantages of the present invention when using a chlorinated starting compound. Examples 1 to 4 were each carried out under the same reaction conditions.
In example 1, no inorganic additive was addec.
In examples 2 to 4, in each case 5% by weight, based on the catalyst (calculated as elemental ruthenium) of inorganic additives was added. These were the following components:
example 2: calcium stearate metal soap (particle size example 3: hydrophilic colloidal precipitated silica - spray-dried (spec, surface area approx. 190 m2/g, mean primary particle size approx. 18 nm, particle size to ISO 13320-1: 30 to 200 urn) (Sipernat® 22 from Evonik-Degussa GmbH)
example 4: hydrophobic, colloidal, chemically .aftertreated silica (spec, surface area approx. 110 m2/g, mean primary particle size approx. 28 nm) (Sipernat® D17 from Evonik-Degussa GmbH)
Procedure: Experiments 1-4
A roll autoclave with a glass insert was initially charged with 250 parts by weight of bis(4-amino-3-rnethylphenyl)methane, 2.5 parls by weight of catalyst suspension and if appropriate the particular amount of inorganic additive (examples 2 to 4). The catalyst suspension comprised 2% by weight, based on the suspension, of ruthenium catalyst

(calculated as elemental ruthenium) and 0.134 % by weight, based on the suspension, of bis(4-amino-3-methylphenyl)methane hydrochloride.
The autoclave was first flushed with gaseous nitrogen, then hydrogen was injected in the cold state until a pressure of 100 bar was established. Then the rolling operation was begun and the temperature was simultaneously increased from room temperature to 230°C within 4 hours. Additional hydrogen was then injected until a pressure of 270 bar was established.
The roll autoclave was then operated at a temperature of 230°C for 5 hours, in the course of which additional hydrogen was injected at hourly intervals in order to maintain the pressure of 270 bar.
Thereafter, the pressure was adjusted once again to 270 bar of hydrogen and both the rolling drive and the heating were switched off.
Once the reaction mixture had reached room temperature, the autoclave was decompressed, and the reaction mixture was removed and the catalyst and inorganic additive were filtered off.
The filtrate was then subjected to a fractional cistillation under reduced pressure.
The results obtained in each case are reproduced below (concentration data in % by weight):

Low-boiling by-products
End product
Intermediate
Starting material
High-boiling by-products

Example 1 Example 2
{comparative, Calcium
without stearate
additive)
1.71 2.33
47.19 68.7
41.86 19/6
0.24 0.16
9.0 9.(i

Example 3 Example 4
Si02 Si02
(hydrophilic) (hydrophobic)
2.46
75.14
12.99
0
9.4
3.0
71.58
16.82
0
8.6

End product: bis(4-amino-3-methylcyclohexyl)methane
Intermediate: (4"amino-3-methylcyclohexyl)(4-,amino-3-methylphenyl)methane

Starting material: bis(4-amino-3-methylphenyl)methane
In examples 2 to 4, significantly higher conversions were achieved compared to example 1.
Example 5:
Example 5 demonstrates a continuous hydrogenation by the process according to the invention.
The preparation of the Ru(IV) oxide hydrate was carried out according to example 1 in DE 21 32 547, with the only exception that the final drying under reduced pressure was omitted. To prepare the catalyst suspension, 5 500 g of the filtercake thus prepared (with 579 g of Ru, calculated 100%) and 280 g of hydrophobic SiO2 (Sipernat D17® from Evonik-Degussa GmbH) were added to a stirred vessel and mixed intensively with 150 kg of a liquid product mixture (output of the hydrogenation reactor), such that the suspension obtained comprised 0.37% by weight of Ru.
The performance of the hydrogenation was pe •formed in a continuous production plant with a cooled high-pressure bubble column reactor. 500 kg/h of a liquid melt of bis(4-aminophenyl)methane and 6.7 kg/h of the catalyst suspension were fed continuously into this reactor. The pressure in he reactor was regulated to 200 bar by replenishing pure hydrogen. The temperature in the reactor was kept constant within the range from 230 to 240°C by cooling.
The product mixture exiting from the reactor was decompressed and cooled to a temperature of 100°C. The analysis of the prociuct mixture by means of gas chromatography gave the following values (concentration data in % by weight):
Reaction output analysis
Low-boiling by-products High-boiling by-products End product Intermediate Starting material
% by weight
7.85
2
90
0.1
0.05
End product: bis(4-aminocyclohexy!)methane Intermediate: (4-aminocyclohexyl)(4-aminopheiyl)methane

Starting material: bis(4-aminophenyl)methane
The hydrogenation was conducted over a period of four weeks under constant conditions without any decline in the reactivity or else a blockage of the reactor as a result of solid sedimentation being observed. Without addition of the inorganic additives, sediments which disrupt production and lead to a decrease in the yield and selectivity generally occur after only one week.

Claims
1. A process for preparing cycloaiiphatic amines by hydrogenating the corresponding aromatic compounds with hydrogen-comprising gas at a temperature of from 30 to 280°C and a pressure of 50 - 350 bar, in the presence of ruthenium catalysts, which comprises performing the hydrogenation in the presence of from 1% by weight to 500% by weight, based on the catalyst (calculated as elemental ruthenium (Ru) , of suspended inorganic additives.
2. The process according to claim 1, wherein the inorganic additives used are substances selected from the group consisting of aluminum oxide, silicon dioxide, alkali metal, alkaline earth meta and aluminum silicates, alkali metal, alkaline earth metal and aluminum borosilicates, titanium dioxide, metal soaps, zeolites, magnesium oxide, zinc oxide, 2irconium oxide and inorganic carbon compounds.
3. The process according to at least one o1 claims 1 to 2, wherein the inorganic additives have a specific surface area o1 from 10 to 1000 m2/g.
4. The process according to at least one oi claims 1 to 3, wherein the inorganic additives have a mean primary particle size of from 1 to 500 nm.
5. The process according to at least one o1 claims 1 to 4, wherein the inorganic additives used are hydrophobic silicates.
6. The process according to at least one o: claims 1 to 5, wherein the aromatic compounds used are mono- or polycycl c aromatic amines.
7. The process according to at least one o: claims 1 to 6, wherein the hydrogenation is performed in continuous mode.
8. The process according to at least one of claims 1 to 7, wherein the hydrogenation is performed in the presence of a solvent.
9. The process according to at least one of claims 1 to 8, wherein the end product formed in the reaction is used as the so vent.
10. The process according to at least one of claims 1 to 9, wherein the hydrogenation is performed in the presence of an Ru catalyst whose precursor is ruthenium oxide hydrate.
11. The process according to at least one of claims 1 to 10, wherein the

hydrogenation is performed in the preserce of from 5% by weight to 200% by weight, based on the catalyst (calculated as elemental ruthenium) of suspended inorganic additives.
12. The process according to at least one of claims 1 to 11, wherein the aromatic starting compounds used in the process lave a chlorine content of 1 ppm or more and/or a content of higher-boiling aromatic by-products of 1 % by weight or more.
13. The process according to at least one of claims 1 to 12, wherein the aromatic compound used is polymeric MDA, anilire, 4,4'-diamino-3,3'-dimethyldiphenyl-methane, 4,4'-diamino-3,3,,5,5'-tetramethyldiphenylmethane and/or 4,4'-diamtnodiphenylmethane.
14. The use of cycloaliphatic amines obtainable according to at least one of claims 1 to 13 as a synthesis unit for the preparat on of surfactants, pharmaceutical and crop protection compositions, stabilizers including light stabilizers, polymers, isocyanates, hardeners for epoxy resins, catalysts for polyurethanes, intermediates for preparing quaternary ammonium compounds, plasticizers, corrosion inhibitors, synthetic resins, ion exchangers, textile assistants, dyes, vulcanization accelerants, emulsifiers and/or as starting substances for the preparation of ureas and polyureas.
15. The use of cyclohexylamine obtainable ciccording to claim 13, as a corrosion inhibitor or vulcanization accelerant.
16. The use of 4,4'-diaminodiphenylmethane!, 4,4'-diamino-3,3',5,5'-tetramethyl-diphenylmethane or 4,4'-diamino-3,3'-dirnethyldiphenylmethane obtainable according to claim 13 as a monomer unin for polyamides, as a hardener for epoxy resins or as a starting material for the preparation of the corresponding isocyanates.

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Patent Number

272003

Indian Patent Application Number

1342/MUMNP/2010

PG Journal Number

12/2016

Publication Date

18-Mar-2016

Grant Date

14-Mar-2016

Date of Filing

24-Jun-2010

Name of Patentee

BASF SE

Applicant Address

67056 Ludwigshafen Germany

Inventors:

#	Inventor's Name	Inventor's Address
1	PFEFFINGER Joachim	Merianstr. 17 67071 Ludwigshafen Germany
2	DOELL Willi	Richard-Wagner-Str.36 67259 Beindersheim Germany

PCT International Classification Number

C07C 209/72, C07C 211/36,C08K 5/00

PCT International Application Number

PCT/EP2009/050341

PCT International Filing date

2009-01-14

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	08150395.5	2008-01-18	EPO