Indian Patents. 253440:PROCESS FOR PURIFYING MESOTRIONE

Title of Invention	PROCESS FOR PURIFYING MESOTRIONE
Abstract	A method for reducing the cyanide levels in a mesotrione sample, said method comprising: (i) taking an aqueous solution of the mesotrione sample in an aqueous solvent, (ii) adjusting the pH of said aqueous solution to a value of 9.5 or higher, and (iii) crystallising the mesotrione out of solution is disclosed.

Full Text	PROCESS FOR PURIFYING MESOTRIONE The present invention relates to a novel method for reducing the cyanide content of a raesotrione sample. Mesotrione (2-(2'-nitro-4'-methylsulphonyl benzoyl)-1,3-cyclohexanedione) is a selective corn herbicide and has the structure of formula (I) Mesotrione is prepared by reacting 2-nitro-4-methylsulphonyl benzoyl chloride with cyclohexanedione to give the enol ester, followed by a rearrangement reaction to give mesotrione, as shown in the following reaction scheme: 2-Nitro-4-methylsulphonyl benzoyl chloride is prepared from the corresponding benzoic acid, which in turn is prepared by oxidation of 2-nitro-4-methylsulphonyl toluene. More details on the preparative route may be found in US4695673. During the rearrangement process, the mesotrione sample is contaminated with cyanide residues from the acetone cyanohydrin catalyst It is therefore an object of the present invention to provide a simple, but effective method for reducing the level of cyanide residues in the mesotrione sample to an acceptable level. It has surprisingly been found that adjusting the pH of a mesotrione sample in aqueous solution has a significant impact on the resulting cyanide levels. Accordingly the present invention provides a method for reducing the cyanide levels in a mesotnone sample, said method comprising: (i) taking an aqueous solution of the mesotrione sample in an aqueous solvent, (ii) adjusting the pH of said aqueous solution to a value of 9.5 or higher, and (Hi) crystallising the mesotrione out of solution. In one embodiment of the invention, the mesotrione sample has previously been isolated, and the aqueous solution is formed by dissolving the isolated sample in an aqueous solvent. In a second embodiment of the invention, the mesotnone sample has not previously been isolated and remains dissolved in the aqueous solvent used in the condensation/rearrangement reaction described above. The aqueous solvent may be selected from the group consisting of water and a water soluble solvent, such as acetonitrile, triethylamine, methanol, ethanol, acetone. Preferably, the aqueous solvent is water. The mesotrione sample is suitably dissolved in the aqueous solvent to give a solution concentration of from 1 % to 30%, suitably from 5%to-15%, and preferably from 8% to 11%. Suitably, the pH of the aqueous solution is raised to a pH of at least 11, and preferably at least 11.5. Suitably, the aqueous mesotrione sample is held at a pH of at least 9.5 for at least 5 minutes, suitably at least 15 minutes and preferably at least 30 minutes. Suitably, the temperature of the aqueous solution should not be greater than 30°C. The crystallisation is carried out according to standard laboratory procedures. For example, for a batch crystallisation, the final pH is adjusted from its starting value of 9.5 or higher to pH 2.5 by charging hydrochloric acid to the crystalliser. The hydrochloric acid should be charged in a manner to ensure adequate mixing. The crystallisation process may also be carried out as a semi-batch or continuous process. The crystallisation step may also include a nitrogen-sparging step, wherein nitrogen is bubbled through the crystallisation vessel in a continuous fashion and sent to a scrubber. The method of the invention may further include a distillation step to remove solvents when the mesotrione sample has not previously been isolated (i.e. the second embodiment of the invention). The distillation step may be carried out either before or after adjusting the pH to 9.5 or higher. The distillation step is suitably canied out using a sufficient amount of steam to remove the solvents from the aqueous solution. Suitably, the method of the invention reduces the cyanide levels in the mesotrione sample to 150ppm or less, more suitably l00ppm or less and preferably 50ppm or less. The invention will now be described further with reference to the following examples, which are illustrative but not limiting of the invention. Example 1 Wet paste mesotrione that was high in total CN was subjected to different treatments in an effort to reduce the total CN content. The results are shown in Table 1, Example 2 Mesotrione was crystallised from samples taken from the plant during the solvent distillation. Samples were taken from the same batch after both 4500 lbs steam (distillation not finished) and 5000 lbs steam (distillation finished) had been used during the distillation process. The pH of the sample was adjusted and the samples were crystallised via standard lab procedures. Total CN content was measured by titration of the wet paste. The results are given in Table 2. Example 3 Mesotrione was crystallised from samples taken from the plant during the solvent distillation. The effects of varying the starting pH of the crystallisation and purging the headspace of the crystallisation vessel with nitrogen were looked at. Samples were taken from the same batch after both 4500 lbs steam (distillation not finished) and S04S lbs steam (distillation finished) has been used during the distillation. The pH of the sample was adjusted and the samples were crystallised via standard lab procedures. Total CN was measured by titration of the wet paste or filtrate. The results are shown in table 3. Example 4 This example looks at the cyanide content of mesotrione crystallised from different feed pH in a continuous crystallisation. The results are shown in Table 4. Example 5 Mesotrione was produced from the acid chloride by a standard condensation/rearrangement reaction. After the condensation/rearrangement reaction, water was added and the pH was adjusted to >11 and held for 1/2hour. The pH was then adjusted to ~5, the mixture distilled and then batch crystallised from either pH 5 or 9.5. The results are shown in Table 5. Example 6 A large sample of mesotrione was obtained at the end of the distillation. This sample was divided into aliquots which were adjusted to a pH >11. A series of batch samples were made up and held agitated at the given pH for the amount of time specified in the table before being quickly adjusted to pH 2.4, filtered, washed and submitted for total cyanide analysis. The results are shown in Table 6. Claims 1. A method for reducing the cyanide levels in a mesotrione sample, said method comprising: (i) taking an aqueous solution of the mesotrione sample in an aqueous solvent, (ii) adjusting the pH of said aqueous solution to a value of 9.5 or higher, and (iii) crystallising the mesotrione out of solution. 2. The method of claim 1, wherein the mesotrione sample has previously been isolated and is redissolved in an aqueous solvent. 3. The method of claim 1, wherein the mesotrione sample has not previously been isolated and is already present as an aqueous solution in an aqueous solvent. 4. The method of claim 3, which further includes a distillation step. 5. The method of claim 4, wherein the distillation step is carried out prior to adjusting the pH of the aqueous solution to a value of 9.5 or higher. 6. The method of claim 4, wherein the distillation step is carried out after adjusting the pH of the aqueous solution to a value of 9.5 of higher. 7. The method according to any one of claim 1 to 6, wherein the crystallisation step 8. also includes a nitrogen sparging step. 9. A method according to any one of claims I to 7, wherein the cyanide levels in the mesotrione sample are reduced to 150ppm or less. Dated this 25 day of September 2006

Full Text

PROCESS FOR PURIFYING MESOTRIONE
The present invention relates to a novel method for reducing the cyanide content of a raesotrione sample.
Mesotrione (2-(2'-nitro-4'-methylsulphonyl benzoyl)-1,3-cyclohexanedione) is a selective corn herbicide and has the structure of formula (I)

Mesotrione is prepared by reacting 2-nitro-4-methylsulphonyl benzoyl chloride with cyclohexanedione to give the enol ester, followed by a rearrangement reaction to give mesotrione, as shown in the following reaction scheme:

2-Nitro-4-methylsulphonyl benzoyl chloride is prepared from the corresponding benzoic acid, which in turn is prepared by oxidation of 2-nitro-4-methylsulphonyl toluene. More details on the preparative route may be found in US4695673.
During the rearrangement process, the mesotrione sample is contaminated with cyanide residues from the acetone cyanohydrin catalyst It is therefore an object of the present invention to provide a simple, but effective method for reducing the level of cyanide residues in the mesotrione sample to an acceptable level.
It has surprisingly been found that adjusting the pH of a mesotrione sample in aqueous solution has a significant impact on the resulting cyanide levels.

Accordingly the present invention provides a method for reducing the cyanide levels in a mesotnone sample, said method comprising:
(i) taking an aqueous solution of the mesotrione sample in an aqueous solvent,
(ii) adjusting the pH of said aqueous solution to a value of 9.5 or higher, and
(Hi) crystallising the mesotrione out of solution.
In one embodiment of the invention, the mesotrione sample has previously been isolated, and the aqueous solution is formed by dissolving the isolated sample in an aqueous solvent.
In a second embodiment of the invention, the mesotnone sample has not previously been isolated and remains dissolved in the aqueous solvent used in the condensation/rearrangement reaction described above.
The aqueous solvent may be selected from the group consisting of water and a water soluble solvent, such as acetonitrile, triethylamine, methanol, ethanol, acetone. Preferably, the aqueous solvent is water. The mesotrione sample is suitably dissolved in the aqueous solvent to give a solution concentration of from 1 % to 30%, suitably from 5%to-15%, and preferably from 8% to 11%.
Suitably, the pH of the aqueous solution is raised to a pH of at least 11, and preferably at least 11.5. Suitably, the aqueous mesotrione sample is held at a pH of at least 9.5 for at least 5 minutes, suitably at least 15 minutes and preferably at least 30 minutes.
Suitably, the temperature of the aqueous solution should not be greater than 30°C.
The crystallisation is carried out according to standard laboratory procedures. For example, for a batch crystallisation, the final pH is adjusted from its starting value of 9.5 or higher to pH 2.5 by charging hydrochloric acid to the crystalliser. The hydrochloric acid should be charged in a manner to ensure adequate mixing. The crystallisation process may also be carried out as a semi-batch or continuous process. The crystallisation step may also include a nitrogen-sparging step, wherein nitrogen is bubbled through the crystallisation vessel in a continuous fashion and sent to a scrubber.
The method of the invention may further include a distillation step to remove solvents when the mesotrione sample has not previously been isolated (i.e. the second embodiment of the invention). The distillation step may be carried out either before or after adjusting the pH to 9.5 or higher. The distillation step is suitably canied out using a sufficient amount of steam to remove the solvents from the aqueous solution.

Suitably, the method of the invention reduces the cyanide levels in the mesotrione sample to 150ppm or less, more suitably l00ppm or less and preferably 50ppm or less.
The invention will now be described further with reference to the following examples, which are illustrative but not limiting of the invention.
Example 1
Wet paste mesotrione that was high in total CN was subjected to different treatments in an effort to reduce the total CN content. The results are shown in Table 1,

Example 2
Mesotrione was crystallised from samples taken from the plant during the solvent distillation. Samples were taken from the same batch after both 4500 lbs steam (distillation not finished) and 5000 lbs steam (distillation finished) had been used during the distillation process. The pH of the sample was adjusted and the samples were crystallised via standard lab procedures. Total CN content was measured by titration of the wet paste. The results are given in Table 2.

Example 3
Mesotrione was crystallised from samples taken from the plant during the solvent distillation. The effects of varying the starting pH of the crystallisation and purging the headspace of the crystallisation vessel with nitrogen were looked at. Samples were taken from the same batch after both 4500 lbs steam (distillation not finished) and S04S lbs steam (distillation finished) has been used during the distillation. The pH of the sample was adjusted and the samples were crystallised via standard lab procedures. Total CN was measured by titration of the wet paste or filtrate. The results are shown in table 3.

Example 4
This example looks at the cyanide content of mesotrione crystallised from different feed pH in a continuous crystallisation. The results are shown in Table 4.

Example 5
Mesotrione was produced from the acid chloride by a standard condensation/rearrangement reaction. After the condensation/rearrangement reaction, water was added and the pH was adjusted to >11 and held for 1/2hour. The pH was then adjusted to ~5, the mixture distilled and then batch crystallised from either pH 5 or 9.5. The results are shown in Table 5.

Example 6
A large sample of mesotrione was obtained at the end of the distillation. This sample was divided into aliquots which were adjusted to a pH >11. A series of batch samples were made up and held agitated at the given pH for the amount of time specified in the table before being quickly adjusted to pH 2.4, filtered, washed and submitted for total cyanide analysis. The results are shown in Table 6.

Claims
1. A method for reducing the cyanide levels in a mesotrione sample, said method
comprising:
(i) taking an aqueous solution of the mesotrione sample in an aqueous
solvent,
(ii) adjusting the pH of said aqueous solution to a value of 9.5 or higher, and
(iii) crystallising the mesotrione out of solution.
2. The method of claim 1, wherein the mesotrione sample has previously been
isolated and is redissolved in an aqueous solvent.
3. The method of claim 1, wherein the mesotrione sample has not previously been
isolated and is already present as an aqueous solution in an aqueous solvent.
4. The method of claim 3, which further includes a distillation step.
5. The method of claim 4, wherein the distillation step is carried out prior to
adjusting the pH of the aqueous solution to a value of 9.5 or higher.
6. The method of claim 4, wherein the distillation step is carried out after adjusting
the pH of the aqueous solution to a value of 9.5 of higher.
7. The method according to any one of claim 1 to 6, wherein the crystallisation step
8. also includes a nitrogen sparging step.
9. A method according to any one of claims I to 7, wherein the cyanide levels in the
mesotrione sample are reduced to 150ppm or less.
Dated this 25 day of September 2006

Documents:

3511-CHENP-2006 CORRESPONDENCE OTHERS 08-09-2011.pdf

3511-CHENP-2006 AMENDED CLAIMS 13-03-2012.pdf

3511-CHENP-2006 AMENDED PAGES OF SPECIFICATION 13-03-2012.pdf

3511-CHENP-2006 CORRESPONDENCE PO.pdf

3511-CHENP-2006 EXAMINATION REPORT REPLY RECEIVED 13-03-2012.pdf

3511-CHENP-2006 FORM-18 07-03-2008.pdf

3511-CHENP-2006 FORM-3 13-03-2012.pdf

3511-CHENP-2006 OTHER PATENT DOCUMENT 13-03-2012.pdf

3511-CHENP-2006 POWER OF ATTORNEY 13-03-2012.pdf

3511-chenp-2006-abstract.pdf

3511-chenp-2006-claims.pdf

3511-chenp-2006-correspondnece-others.pdf

3511-chenp-2006-description(complete).pdf

3511-chenp-2006-form 1.pdf

3511-chenp-2006-form 26.pdf

3511-chenp-2006-form 3.pdf

3511-chenp-2006-form 5.pdf

3511-chenp-2006-pct.pdf

« Previous Patent

Next Patent »

Patent Number

253440

Indian Patent Application Number

3511/CHENP/2006

PG Journal Number

30/2012

Publication Date

27-Jul-2012

Grant Date

20-Jul-2012

Date of Filing

25-Sep-2006

Name of Patentee

SYNGENTA PARTICIPATIONS AG

Applicant Address

SYNGENTA PARTICIPATIONS AG, SCHWARZWALDALLEE 215, CH-4058

Inventors:

#	Inventor's Name	Inventor's Address
1	BENKE, ALAN, HENRY	COLD CREEK PLANT, BUCKS ,ALABAMA
2	WICHERT ,JULIE,MARIE	COLD CREEK PLANT, BUCKS ,ALABAMA

PCT International Classification Number

C07C315/06

PCT International Application Number

PCT/EP05/02230

PCT International Filing date

2005-03-03

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	0406894.6	2004-03-26	U.K.