Title of Invention

"A PROCESS FOR THE ISOLATION OF COMPOUNDS USEFUL AS ANTI ULCER ,FROM OROXYLUM INDICUM

Abstract

The present invention provides the identification of Oroxylum indicum an Indian medicinal plant as possessing potent where gastrointestinal toxicity inhibitors. The hexane extract of dried stem bark of Oroxylum indicum constitutes 95% of three major active principles identified as Oroxylin A, Chrysin, Baicalein and acetone extract contains six major active principles, that contains apart from Oroxylin A, Chrysin, Baicalein and compounds namely methoxy chrysin, Oroxyloside methyl ester and chrysin-7-o methyl glycoside and synthesized analogues of Oroxylin, Chrysin in substantial yields. These mixtures and molecules may find preventive as well as therapeutic application in controlling disorders of gastrointestinal disorders and diseases

Full Text

Field of invention The present invention relates to the identification of Oroxylum indicum, Indian medicinal plant as a rich source for flavanoid compounds. As a result of literature survey and in our present study we have identified mucoprotective and antigastric ulcer properties in the flavone class of compounds isolated. Invention identifies a flavanoids mixture in substantial yields from hexane and acetone extracts. The hexane extract was fractionated, purified and identified the compounds as Oroxylin A, Chrysin and Baicalein. Further more acetone extract was purified and identified the compounds as methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O-methyl glycoside. Invention of potent antigastric-ulcer compounds were accompanied with synthesis of few analogues derived from the oroxylin and chrysin, which were isolated from this plant in good yields. As per the results, oroxyloside methyl ester compound showed potent activity against gastric ulcers induced by aspirin, ethanol, stress and pylorus ligation. Back ground of invention Gastric or peptic ulcer constitutes a major disease that affects human gastrointestinal tract and major health problem both in terms of morbidity and mortality. The common clinical features of peptic ulcers are hyperacid secretion and ulcer formation in the stomach and duodenal part of the intestine. Peptic ulcer disease (PUD) primarily effects the adult population in developed and developing countries. The risk for peptic ulcer was highest in generations born before the turn of the century and has declined in all subsequent generations. Low family income, old age, smoking lower educational attainment, ethnicity, increased gastric acid output, Helicobacter pylori, NSAIDs and stress are that act as significant and independent basic risk factors in PUD risk factor. The prevalence of upper GI diseases is increasing in subjects aged 65 years and over. Almost 40% of GU (gastric ulcer) and 25% of DU (duodenal ulcer) in the elderly patients are associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). Gastrointestinal (GI) side effects include ulcers (found at endoscopy in 15-30 % of patients using NSAIDs regularly), complications such as upper GI bleeding (annual incidence of 1.0-1.5 %) and development of upper GI symptoms such as dyspepsia (occurring in up to 60 % patients taking NSAIDs). NSAIDs are among most widely used prescribed drugs world wide for anti-inflammatory, analgesic and antipyretic effects, whereas low dose aspirin (also a NSAID) is used for cardiovascular prophylaxis. Although the therapeutic benefits of these drugs are substantial, their use is limited by their gastroduodenal toxicity, some of which can be serious or even fatal. Established risk factors for NSAIDs induced GI complications are age, ulcer history, heavy alcohol consumption, individual NSAIDs, dose association with corticoid or aspirin or anticoagulant (ulcer heamorrhage). The therapeutical acquisition of PUD of the year 2004 is the use of COX-2 inhibitors reduced significantly the GI side effects of anti-inflammatory treatments. Since cardiac adverse effects of certain COX-2 inhibitors (NSAIDs) had been reported, the treatments with COX-2 inhibitors came widely into question. Aspirin is a very useful medication for the prevention of cardiovascular thrombotic events in patients with or those at risk for cardiovascular disease (CVD). Patients being treated with aspirin, even at 81 mg/day for cardioprotection, should be assessed for factors that increase the risk for GI injury. Stress has wide spread effects on various body systems. Stress has long been implicated as one of the risk factors for coronary diseases. Stress, defined as an acute threat to homeostasis, evokes an adaptive or allostatic response and can have both a short and long term influence on the function of the gastrointestinal tract. Stress ulceration of the stomach is associated with clinical conditions like trauma, head injury, burns, shock, sepsis and neurological disorders; and is now regarded as a multifactorial phenomenon. It is reported to result from interaction between mucosal, vascular and neuro-humoral factors and the autonomic nervous system plays a crucial role. Circulatory disturbances and the nutritional deficiency are thus induced in the local tissue, which are then followed by a rapid appearance of a deep ulcer. Gastrointestinal complications frequently occur in patients admitted to the intensive care unit. Of this ulceration and bleeding related to stress-related mucosal disease can lengthen hospitalization and increases mortality. The prophylactic regimen chosen to prevent stress ulcer bleeding should take into account the risk factors and underlying disease state of individual patients to provide the best therapy to those most likely to benefit. Ethanol is common cause of acute gastric mucosal injury in both human and animals. This gastritis may produce life-threatening hemorrhage that requires surgical intervention. The mortality rate of such an intervention is at least 30%. In the rat persistence of gastric mucosal ischemia produces chronic ulceration of the stomach. Several other factors are associated with ulcer formation although this may be an indirect relationship such factors include hereditary, smoking, elevated calcium level, corticosteroids in high dose. The majority of peptic ulcers causing growing burning or aching pain in the region of the stomach made worse by or unrelated to food. Pain tends to be worse at night and occurs usually 1 to 3 hours after food during the day. Additionally there may be food aversion, weight loss, nausea, belching or bloating. There is great individual variation and occasionally the pain may be referred to the back or the upper quadrant of the abdomen. Complications include bleeding, obstruction, perforation or intractable pain. Prophylactic options for patients suffering with gastrointestinal ulceration include antacids, sucralfate, histamine2-receptor antagonists (H2RAs), prostaglandins, muscarinic Ml-antagonists and proton pump inhibitors. Therapy has been and still is largely empirical. The prostaglandin's fulfilled their early promise and muscarinic M,-antagonists, although more selective than the earlier anti-cholinergic agents, have limited application. Inhibition of the H + / K+ ATPase by non-competitive agents is limited to short-term administration and the development of a potent selective gastrin antagonist is yet be realized. Reduction of symptoms, nullifying the side effects and improvement in quality of life are among the top priorities of diseases for the suffering persons. Although these factors need to be considered and balanced in evaluating new therapies for widespread use. The reduction in risk in a specific patient population should be considered before a particular regimen is deemed ineffective or too costly. The plants create unexpected and novel structure to protect themselves from predator organism. By trail and error, several plants and plant products are identified as drugs. Natural product drugs although are highly effective and free from toxic side effects, have a disadvantage with respect to short supply and chemical structure, which makes their manufacture difficult or impossible. Natural product drugs have been a source of lead structure in drug design and development. Semi synthetic analogues or synthetic analogues closely related to the natural product drug of lead are synthesized and screened to disorder their action. In the light of above descriptions, in our isolation work flavonoids have been isolated which are potent antiulcer agents increasing the gastric pH, mucosal lining of stomach and related disorders, led to the identification of Oroxylum indicum, which contained in substantial yields potent antiulcer flavonoids for the first time. Oroxylum indicum Vent has been advocated in traditional medical practice of India for several diseases. In folklore medicine in India, the powdered stem bark is used to treat dysentery, diarrhea, sore throat, cough and bone fractures (Kausik, P and Dhaman A. K, The medicinal plants and crude drugs of India, 2000, 398). Objects of invention The main object of the present invention is to examine and assess the relation between plant-originated substances and their bioactivity measured in terms of cytoprotective and antigastric ulceric activities and to determinate if these effects are capable of affecting the gastric mucosal lesions induced by absolute ethanol, cold stress, aspirin and pylorus ligated. The object of the invention is to assign new activity as anti ulcer compounds Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O- methyl glucoside, isolated form either hexane extract or the acetone extract of Oroxylum indicum and synthetic analogues form Oroxylin A and chrysin. Further more all this isolated and synthetic compounds use for the therapeutic use as control of ulcer and also some more diseases. The present invention also relates to activity of these compounds and oroxyloside methyl ester (new compound) and another two compounds namely methoxy chrysin and chrysin-7-O- methyl glucoside as first time isolated form this plant Oroxylum indicum. All synthetic analogues prepared in the present invention is also new synthetic compounds. This invention further identified a first time anti ulcer activity using these compounds Summary of the invention Accordingly the present invention provides a pharmaceutical composition comprising compounds selected from the group consisting of Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O- methyl glucoside and synthetic analogs of oroxylin-A as a acyl ester derivatives and alkyl amino derivatives of chrysin, either alone or with pharmaceutically acceptable additives, adjuvant or carriers. In an embodiment of the present invention compounds used are represented by a group of following compounds: Figl: Oroxylin-A [5,7-Dihydroxy-6-methoxy-2-phenylchromen-4-one ]; Fig2: [5,7-dihydroxy-2-phenyl-chromen-4-one ]; Fig.3: [5,6,7-trihydroxy-2-phenyl-chromen-4-one] (Baicalein) Fig.4: Methoxy chrysin [5-hydroxy-7-methoxy-2-phenyl-chromen-4-one ]; Fig.5: Oroxoloside methyl ester [3,4,5-trihydroxy-6-(6-methoxy- 4-oxo-2-phenyl-4-H-chromen-7-yoloxy) tetrahydro-pyran-2-carboxylicacid methyl ester]; Fig 6: chrysin-7-O- methyl glycoside [3,4,5-trihydroxy-6-(4-oxo-2-phenyl-4-H-chromen-7-yoloxy) tetrahydro-pyran-2-carboxylicacid methyl ester ]; Fig.7: [Heptadecanoic acid 5-hydroxy-6-methoxy- 4-oxo-2-phenyl-4H-chromen-7-yl ester] (ORC-16); Fig.8: [4-methyl-benzoic acid 5-hydroxy-6-methoxy-4-oxo- 2-phenyl-4-H-chromen-7-yl ester] (ORPM-1 ); FIG:9 [5-Hydroxy-2-phenyl-7-(3-piperidin-l-yl-propoxy)-chromen-4-one] (CPP-2) ; Fig.10: [5-Hydroxy-7-(3-morpholin-4-yl-propoxy)-2-phenyl chromen-4-one] (CHM-2); Fig.ll: [7-(3-Dimethyl amino-propoxy)-5-hydroxy-2-phenyl chromen-4-one]( CHN-2); Fig. 12: [5-Hydroxy-7-[3-(4-methyl-piperzin-l-yl]- propoxy)-2-phenyl hromen-4-one] (NMC-2); Fig.13: [5-Hydroxy-7-[4-(4-methyl-piperzin-l-yl]-butoxy)-2-phenyl chromen-4-one] (NMC- 3; Fig.l4:[5-Hydroxy-7-(4-morpholin-4-yl-butoxy)-2-phenylchromen-4-one] (CHM-3); Fig. 15: [5-Hydroxy-6-methoxy-2-phenyl-7-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro- pyran-2-yloxy)-chromen-4-one](OAG); Fig. 16: [5-Hydroxy-2-phenyl-7-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2- yloxy)-chromen-4-one] (CG); Fig. 17: [3,4,5-Trihydroxy-6-(5-hydroxy-6-methoxy-4- oxo-2-phenyl-4H-chromen-7-yloxy)- tetrahydro-pyran-2-carboxylic acid] (OA-5 Acid). In yet another embodiment the compounds used are represented by the following general formula: (Formula Removed) The present invention further provides a process for the isolation of Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O- methyl glycoside as anti ulcer compounds form Oroxylum indicum the said process comprising the steps of: (a) extracting dried stem bark of Oroxylum indicum with hexane by using soxlet apparatus (b) filtering the extract to separate out solids (c) subjecting the residue to a first elution with about 1 % methanol in chloroform to obtain Oroxylin A and (d) subjecting the residue of step c to a second elution with about 2% methanol in chloroform to obtain Chrysin and (e) subjecting the residue of step d to a third elution with about 3% methanol in chloroform to obtain Baicalein. In yet another embodiment the present invention provides a process for the isolation of Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O- methyl glycoside as anti ulcer compounds form Oroxylum indicum the said process comprising the following steps a) extraction with acetone of the hexane extracted material of claim 2 to obtain a residue b) subjecting the residue of step (a) to a first elution with about 1% methanol in chloroform to obtain Oroxylin A and c) subjecting the residue of step b to a second elution with about 2% methanol in chloroform to obtain Chrysin and d) subjecting the residue (step c) to a third elution with about 3% methanol in chloroform to obtain Baicalein e) subjecting the residue (step d) to fourth elution with about 4 % methanol in chloroform to obtain Methoxy chrysin f) subjecting the residue (step e ) to a fifth elution with about 5%methanol in chloroform to obtain Oroxyloside methyl ester g) subjecting the residue (step f ) to a sixth elution with about 7% methanol in chloroform to obtain chrysin-7-O- methyl glycoside. In yet another embodiment the compounds obtained is represented by the group of following compounds: Figl: Oroxylin-A [5,7-Dihydroxy-6-methoxy-2-phenylchromen-4-one ]; Fig2: [5,7-dihydroxy-2-phenyl-chromen-4-one ]; Fig.3: [5,6,7-trihydroxy-2-phenyl-chromen-4-one] (Baicalein) Fig.4: Methoxy chrysin [5-hydroxy-7-methoxy-2-phenyl-chromen-4-one ]; Fig.5: Oroxoloside methyl ester [3,4,5-trihydroxy-6-(6-methoxy- 4-oxo-2-phenyl-4-H- chromen-7-yoloxy) tetrahydro-pyran-2-carboxylicacid methyl ester]; Fig 6: chrysin-7-O- methyl glycoside [3,4,5-trihydroxy-6-(4-oxo-2-phenyl-4-H-chromen-7- yoloxy) tetrahydro-pyran-2-carboxylicacid methyl ester ]; Fig.7: [Heptadecanoic acid 5-hydroxy-6-methoxy- 4-oxo-2-phenyl-4H-chromen-7-yl ester] (ORC-16); Fig.8: [4-methyl-benzoic acid 5-hydroxy-6-methoxy-4-oxo- 2-phenyl-4-H-chromen-7-yl ester] (ORPM-1); FIG:9 [5-Hydroxy-2-phenyl-7-(3-piperidin-l-yl-propoxy)-chromen-4-one] (CPP-2) ; Fig.10: [5-Hydroxy-7-(3-morpholin-4-yl-propoxy)-2-phenylchromen-4-one] (CHM-2); Fig.ll: [7-(3-Dimethyl amino-propoxy)-5-hydroxy-2-phenyl chromen-4-one]( CHN-2); Fig. 12: [5-Hydroxy-7-[3-(4-methyl-piperzin-l-yl]- propoxy)-2-phenyl hromen-4-one] (NMC-2); Fig.13: [5-Hydroxy-7-[4-(4-methyl-piperzin-l-yl]-butoxy)-2-phenyl chromen-4-one] (NMC- 3; Fig. 14: [5-Hydroxy-7-(4-morpholin-4-yl-butoxy)- 2-phenyl chromen-4-one](CHM-3); Fig.l5:[5-Hydroxy-6-methoxy-2-phenyl-7-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro- pyran-2-yloxy)-chromen-4-one](OAG); Fig. 16: [5-Hydroxy-2-phenyl-7-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2- yloxy)-chromen-4-one] (CG); Fig. 17: [3,4,5-Trihydroxy-6-(5-hydroxy-6-methoxy-4- oxo-2-phenyl-4H-chromen-7-yloxy)- tetrahydro-pyran-2-carboxylic acid] (OA-5 Acid). In yet another embodiment the pharmaceutical composition is useful for the treatment of gastric ulcer comprising administering to a subject a pharmaceutically acceptable amount of a mucoprotective and antigastric ulcer agent selected the group consisting of OA-5, analogues thereof selected in turn from the group NMC-2, NMC-3, CHN-2, CHM-3, CPP-2, CG, and CGL. In yet another embodiment OA-5 provides mucoprotective property up to 77.84% induced by aspirin at dose level of 50 mg/kg of bodyweight in comparison with the reference standard ranitidine up to 74.15% protective at dose level of 50 mg/kg of bodyweight. In yet another embodiment OA-5 provides mucoprotective property up to 74.55% induced by aspirin at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides mucoprotective property up to 40.98% induced by aspirin at dose level of 15 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides mucoprotective property up to 40.98% induced by aspirin at dose level of 10 mg/kg of bodyweight in comparison with the reference standard In yet another embodiment, OA-5 provides mucoprotective property up to 18.75% induced by aspirin at dose level of 5 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides reduced glandular ulcer index up to 78.22% induced by cold stress restraint ulceration at dose level of 50 mg/kg of bodyweight in comparison with the reference standard ranitidine up to 78.83% reduction of ulcer index at dose level of 50 mg/kg of bodyweight In yet another embodiment OA-5 provides reduced glandular ulcer index up to 75.45% induced by cold stress restraint ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides reduced glandular ulcer index up to 50.14% induced by cold stress restraint ulceration at dose level of 15 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides reduced glandular ulcer index up to 41.92% induced by cold stress restraint ulceration at dose level of 10 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides reduced glandular ulcer index up to 31.55% induced by cold stress restraint ulceration at dose level of 5 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 85.00% induced by 50% ethanol ulceration at dose level of 50 mg/kg of bodyweight in comparison with reference to the standard ranitidine up to 61.26% gastric mucosal protection at dose level of 50 mg/kg of bodyweight in comparison with the reference to standard omeprazole up to 67.51% gastric mucosal protection at dose level of 30 mg/kg of bodyweight and in comparison with the reference to standard sucralfate up to 87.5% gastric mucosal protection at dose level of 400 mg/kg of bodyweight. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 82.5% induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference to standards. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 60.61% induced by 50% ethanol ulceration at dose level of 15 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 35.00% induced by 50% ethanol ulceration at dose level of 10 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 30.01% induced by 50% ethanol ulceration at dose level of 5 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides elevation pH up to 4.95 induced by 50% ethanol ulceration at dose level of 50 mg/kg of bodyweight comparison with reference standard ranitidine up to 4.96 pH elevation at dose level of 50 mg/kg of bodyweight in comparison with the reference standard omeprazole up to 4.65 pH elevation at dose level of 30 mg/kg of bodyweight and comparison with the reference standard sucralfate up to 4.00 pH elevation at dose level of 400 mg/kg of bodyweight. In yet another embodiment OA-5 provides elevation pH up to 6.81 induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides elevation pH up to 4.5 induced by 50% ethanol ulceration at dose level of 15 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides elevation pH up to 4.66 induced by 50% ethanol ulceration at dose level of 10 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides elevation pH up to 3.5 induced by 50% ethanol ulceration at dose level of 5 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides increase gastric juice secretion up to 7.4ml induced by 50% ethanol ulceration at dose level of 50 mg/kg of bodyweight comparison with reference standard ranitidine up to 5.0ml gastric juice secretion at dose level of 50 mg/kg of bodyweight in comparison with the reference standard omeprazole up to 3.5ml gastric juice secretion at dose level of 30 mg/kg of bodyweight and comparison with the reference standard sucralfate up to 4.00ml gastric juice secretion at dose level of 400 mg/kg of bodyweight. In yet another embodiment OA-5 provides increase gastric juice secretion up to 5.5ml induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides increase gastric juice secretion up to 4.5ml induced by 50% ethanol ulceration at dose level of 15 mg/kg of bodyweight in comparison with reference standards. In yet another embodiment OA-5 provides increase gastric juice secretion up to 4.2ml induced by 50% ethanol ulceration at dose level of 10 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides increase gastric juice secretion up to 4.0ml induced by 50% ethanol ulceration at dose level of 5 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment OA-5 provides reduction in acidity level up to 18.25m Eg induced by 50% ethanol ulceration at dose level of 50 mg/kg of bodyweight in comparison with reference standard ranitidine up to 26.74m Eg mean level of reduction in acidity at dose level of 50 mg/kg of bodyweight, in comparison with the reference standard omeprazole up to 32.01m Eg mean level of reduction in acidity at dose level of 30 mg/kg of bodyweight and in comparison with the reference standard sucralfate up to 52.00m Eg mean level of reduction in acidity at dose level of 400 mg/kg of bodyweight. In yet another embodiment OA-5 provides reduction in acidity level up to 12.4m Eg induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment OA-5 provides reduction in acidity level up to 29.66m Eg induced by 50% ethanol ulceration at dose level of 15 mg/kg of bodyweight in comparison with reference standards. In yet another embodiment OA-5 provides reduction in acidity level up to 31.33m Eg induced by 50% ethanol ulceration at dose level of 10 mg/kg of bodyweight in comparison with reference standards. In yet another embodiment OA-5 provides reduction in acidity level up to 42.66m Eg induced by 50% ethanol ulceration at dose level of 5 mg/kg of bodyweight in comparison with reference standards. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 79.85% induced by pylorus ligated ulceration at dose level of 50 mg/kg of bodyweight in comparison with reference to the standard ranitidine up to 78.39% gastric mucosal protection at dose level of 50 mg/kg of bodyweight. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 75.07% induced by pylorus ligated ulceration at dose level of 25mg/kg of bodyweight in comparison with reference to the standard. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 70.07% induced by pylorus ligated ulceration at dose level of 15mg/kg of bodyweight in comparison with reference to the standard. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 59.78% induced by pylorus ligated ulceration at dose level of lOmg/kg of bodyweight in comparison with reference to the standard. In yet another embodiment OA-5 provides marked gastric mucosal protection up to 46.80% induced by pylorus ligated ulceration at dose level of 5mg/kg of bodyweight in comparison with reference to the standard. In yet another embodiment OA-5 provides elevation pH up to 4.62 induced by pylorus ligated ulceration at dose level of 50 mg/kg of bodyweight in comparison with reference standard ranitidine up to 4.75 pH elevation at dose level of 50 mg/kg of bodyweight. In yet another embodiment OA-5 provides elevation pH up to 5.62 induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides elevation pH up to 4.35 induced by pylorus ligated ulceration at dose level of 15 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides elevation pH up to 3.58 induced by pylorus ligated ulceration at dose level of 10 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides elevation pH up to 3.25 induced by pylorus ligated ulceration at dose level of 5 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides increase in gastric juice secretion up to 2.5ml induced by pylorus ligated ulceration at dose level of 50 mg/kg of bodyweight in comparison with reference standard ranitidine up to 1.82 ml gastric juice secretion at dose level of 50 mg/kg of bodyweight. In yet another embodiment OA-5 provides increase in gastric juice secretion up to 2.1ml induced by pylorus ligated ulceration at dose level of 50 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment OA-5 provides increase in gastric juice secretion up to 3.62 ml induced by pylorus ligated ulceration at dose level of 15 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment OA-5 provides increase in gastric juice secretion up to 3.5ml induced by pylorus ligated ulceration at dose level of 5 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment OA-5 provides reduction in acidity level up to 32.66m Eg induced by pylorus ligated ulceration at dose level of 50 mg/kg of bodyweight in comparison with reference standard ranitidine up to 31.8m Eg mean level of reduction in acidity at dose level of 50 mg/kg of bodyweight. In yet another embodiment OA-5 provides reduction in acidity level up to 30.18m Eg induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment OA-5 provides reduction in acidity level up to 30.25m Eg induced by pylorus ligated ulceration at dose level of 15 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment OA-5 provides reduction in acidity level up to 42.9m Eg induced by pylorus ligated ulceration at dose level of 10 mg/kg of bodyweight in comparison with reference standard. OA-5 provides reduction in acidity level up to 45.5m Eg induced by pylorus ligated ulceration at dose level of 5 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment NMC-2 provides reduced glandular ulcer index up to 59.67% induced by cold stress restraint ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment NMC-2 provides gastric mucosal protection up to 57.5% induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference to standards. In yet another embodiment NMC-2 provides elevation pH up to 4.75 induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment NMC-2 provides increase gastric juice secretion up to 4.8ml induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment NMC-2 provides reduction in acidity level up to 30.8m Eg induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CHN-2 provides mucoprotective property up to 55.68% induced by aspirin at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CHM-2 provides mucoprotective property up to 55.59% induced by aspirin at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CHM-3 provides mucoprotective property up to 51.74% induced by aspirin at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CPP-2 provides mucoprotective property up to 66.77% induced by aspirin at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment NMC-3 provides reduced glandular ulcer index up to 57.92% induced by cold stress restraint ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CHN-2 provides reduced glandular ulcer index up to 56.12% induced by cold stress restraint ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CHM-3provides reduced glandular ulcer index up to 52.64% induced by cold stress restraint ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CPP-2 provides reduced glandular ulcer index up to 61.44% induced by cold stress restraint ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CHN-2 provides marked gastric mucosal protection up to 58.44% induced by pylorus ligated ulceration at dose level of 25mg/kg of bodyweight in comparison with reference to the standard. In yet another embodiment CHN-2 provides elevation pH up to 4.25 induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CHN-2 provides increase in gastric juice secretion up to 1.8ml induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CHN-2 provides reduction in acidity level up to 31.18m Eg induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CPP-2 provides marked gastric mucosal protection up to 68.47% induced by pylorus ligated ulceration at dose level of 25mg/kg of bodyweight in comparison with reference to the standard. In yet another embodiment CPP-2 provides elevation pH up to 3.25 induced by pylorus ligated ulceration at dose level of 25 mg/kg of body weight in comparison with the reference standard. In yet another embodiment CPP-2 provides increase in gastric juice secretion up to 2.6ml induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CPP-2 provides reduction in acidity level up to 29.06m Eg induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CG provides mucoprotective property up to 52% induced by aspirin at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CGL provides mucoprotective property up to 70.46% induced by aspirin at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CGL provides reduced glandular ulcer index up to 50.22% induced by cold stress restraint ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standard. In yet another embodiment CG provides gastric mucosal protection up to 52.5% induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference to standards. In yet another embodiment CG provides elevation pH up to 5.9 induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment CG provides increase gastric juice secretion up to 5.9 ml induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment CG provides reduction in acidity level up to 41.33m Eg induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CGL provides gastric mucosal protection up to 62.5% induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference to standards. In yet another embodiment CGL provides elevation pH up to 3.9 induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment CGL provides increase gastric juice secretion up to 4.6 ml induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with the reference standards. In yet another embodiment CGL provides reduction in acidity level up to 39m Eg induced by 50% ethanol ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CG provides marked gastric mucosal protection up to 50.25% induced by pylorus ligated ulceration at dose level of 25mg/kg of bodyweight in comparison with reference to the standard. In yet another embodiment CG provides elevation pH up to 3.5 induced by pylorus ligated ulceration at dose level of 25 mg/kg of body weight in comparison with the reference standard. In yet another embodiment the pharmaceutical composition provides increase in gastric juice secretion up to 1.5ml induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CO provides reduction in acidity level up to 44.33m Eg induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CGL provides marked gastric mucosal protection up to 60.17% induced by pylorus ligated ulceration at dose level of 25mg/kg of bodyweight in comparison with reference to the standard. In yet another embodiment CGL provides elevation pH up to 3.08 induced by pylorus ligated ulceration at dose level of 25 mg/kg of body weight in comparison with the reference standard. In yet another embodiment CGL provides increase in gastric juice secretion up to 4.83ml induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. In yet another embodiment CGL provides reduction in acidity level up to 40m Eg induced by pylorus ligated ulceration at dose level of 25 mg/kg of bodyweight in comparison with reference standard. Detailed description of the invention In accordance with the objects of this invention the present invention identified a new source namely Oroxylum indicum dried stem bark possessing substantial yields and compounds have the activity against gastric ulcer. This invention identifies presence of isolated compounds Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O- methyl glucoside and synthetic analogs of oroxylin-A as a acyl ester derivatives and alkyl amino derivatives of chrysin. The present invention also identifies for the first time oroxyloside methyl ester as new naturally occurring compound from acetone extract of Oroxylum indicum. In an other embodiment of the invention compound methoxy chrysin is isolated for the first time from acetone extract of Oroxylum indicum Still another embodiment of the present invention provides process for the isolation of Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O-methyl glycoside as anti ulcer compounds form Oroxylum indicum the said process comprised following steps (1) hexane extract, (2) acetone extract. a) extraction of dried stem bark of Oroxylum indicum with hexane by using soxlet apparatus b) extract was filtered to afford solid separate out c) subjecting the residue to a first elution with 1% methanol in chloroform to obtain Oroxylin A and d) subjecting the residue (step c) to a second elution with 2% methanol in chloroform to obtain Chrysin and e) subjecting the residue (step d) to a third elution with 3% methanol in chloroform to obtain Baicalein A further object of the invention relates to the isolation of these three compounds namely Oroxylin-A, Chrysin and Baicalein from Oroxylum indicum with hexane extract. Further more all these compounds isolated from Oroxylum indicum shows anti-ulcer activity for the first time. Further more extraction of dried stem bark of Oroxylum indicum with acetone, and process for isolation of compounds along with Oroxylin A, Chrysin and Baicalein, compounds Methoxy chrysin and Oroxyloside methyl ester and chrysin-7-O- methyl glycoside the said process comprising steps of a) subsequent extraction with acetone of the hexane extracted material by the same procedure to obtain the residue b) subjecting the residue to a first elution with 1% methanol in chloroform to obtain Oroxylin A and c) subjecting the residue (step b) to a second elution with 2% methanol in chloroform to obtain Chrysin and d) subjecting the residue (step c) to a third elution with 3% methanol in chloroform to obtain Baicalein e)subjecting the residue (step d) to fourth elution with 4 % methanol in chloroform to obtain Methoxy chrysin f) subjecting the residue (step e ) to a fifth elution with 5%methanol in chloroform to obtain Oroxyloside methyl ester g) subjecting the residue (step f) to a sixth elution with 7% methanol in chloroform to obtain chrysin-7-O- methyl glycoside. Further invention identifies that in above said process compound Oroxyloside methyl ester was identified as first isolated natural compound and compounds methoxy chrysin and chrysin-7-O- methyl glycoside identified as a first time isolated compounds form this plant Oroxylum indicum, and the compound Oroxyloside methyl ester shows excellent potent molecule for the antiulcer activity and compound chrysin-7-O- methyl glycoside shows very good activity against gastric ulcer. Present invention relates to the identification of isolation of potent antiulcer molecules from extracts of Oroxylum indicum, which may find preventive as well as therapeutic applications for the control of gastrointestinal toxicity along with other complications further use in disorders where gastrointestinal toxicity inhibition play an important role in prevention and treatment of diseases not mentioned in this description. The present invention relies on the identification of Oroxylum indicum an Indian medicinal plant as possessing potent where gastrointestinal toxicity inhibitors. The hexane extract of dried stem bark of Oroxylum indicum constitutes 95% of three major active principles identified as Oroxylin A, Chrysin, Baicalein and acetone extract contains six major active principles, that contains apart from Oroxylin A, Chrysin, Baicalein and compounds namely methoxy chrysin, Oroxyloside methyl ester and chrysin-7-o methyl glycoside and synthesized analogues of Oroxylin, Chrysin in substantial yields. These mixtures and molecules may find preventive as well as therapeutic application in controlling disorders of gastrointestinal disorders and diseases. Applications , administration and the formulations; These antigastric ulcer molecule(s) may be administrated by any suitable conventional method prevalent in pharmaceutical practice for the treatment of gastrointestinal toxicity, control gastric pH and reduction ulcers risk factors in GI toxicity, and also in disease condition such as inflammation, stress conditions, NSAID therapy requiring inhibition of gastric acid output, formation of mucosal lining, elevate the gastric acid pH for prevention and treatment of diseases mentioned and not mentioned in this invention. The potent antiulcer OA-5 molecule in this invention antagonize the aggressive factors, which play in the pathogenesis of gastric lesions and augment defensive factors to protect the gastric mucosal from injury. Application as the case of antigastric ulcer molecules may preferably be taken orally and potentiate the mechanism of action and hence impart better therapeutic action. The antigastric ulcer molecules present in pharmaceutical preparation in this invention may be formulated with any of the suitable pharmaceutically acceptable additive, carrier, vehicle, food preparations etc., suitable for human application. The materials should be selected such that they should not interfere with the potency and the property of the mixture or the molecule but materials that can add to or improve the activity, are preferred and can decided by the conventional art and the skills available in formulary. Effective dose: Effective dose level and duration of drug administration may be decided by the skill of ordinary art in order to bring therapeutic parameter of the disease under consideration under the control. The actual rate, amount of applications, and the time of administration may vary depending upon the disease condition and severity and may be irrespective of the concentration and duration as described in the examples of this invention. Synthesis of 7-O-acyl derivatives of Oroxylin A: (Formula Removed) Procedure: The corresponding acid, EDCI (0.836 mmol) and HOBt (0.69 mmol) were cooled to 0°C and stirred in anhydrous methylene chloride (5 ml) for 15-30 min under nitrogen atmosphere. To this mixture, Oroxylin A (0.704 mmol) in anhydrous N, N- dimethylformaldehye (3 ml) was added. The entire reaction mixture was stirred at room temperature for 4-5 h under nitrogen. After completion of the reaction (TLC), the reaction mixture was poured into ice water and washed with methylene chloride (2 x 10 ml). The combined organic layers were dried over anhydrous sodium sulphate and concentrated under vacuum. Residue was purified by column chromatography on silica gel (60-120mesh) to give corresponding 7-O- acyl derivatives of Oroxylin A ORPM-1 and ORC-16 in good yields. Preparation of alkyl amino derivatives of chrysin: (Formula Removed) General procedure for the preparation of 7-O-alkylamino derivatives of Chrysin: 0 General procedure for the preparation of 7-O-alkyl derivatives of chrysin : To a mixture of chrysin 1 (1 g, 3.93 mmol) and anhydrous potassium carbonate (0.81 g, 5.8 mmol) in 20ml acetone, corresponding dibromoalkane (1, 3-dibromo propane for 2a, 1, 4-dibromo butane for 2b. The mixture was refluxed under nitrogen atmosphere for 3-4 h. After completion of the reaction potassium carbonate was filtered and washed with excess of acetone (2 x 50 ml). The combined acetone layers are concentrated under vacuum. The residue was purified by column chromatography on silica gel (60-120 mesh) to yield 7-O-bromoalkyl chrysin (2a, 2b) in pure form. ii) General procedure for the preparation of 7-O-alkvl amino derivatives of chrvsin: To a mixture of bromoalkyl chrysin (2a, 2b) and anhydrous potassium carbonate (2.41 g, 17.2 mmol) in 20ml acetonitrile, corresponding amine was added. The mixture was refluxed under nitrogen atmosphere for 3-4 h. After completion of the reaction, the reaction mixture was brought to room temperature and was poured into ice water and washed with methylene chloride (2 x 10 ml). The combined organic layers were dried over anhydrous sodium sulphate and concentrated under vacuum. The residue was purified by column chromatography on silica gel (60-120mesh) to give the corresponding 7-O-alkylaminoderivatives of chrysin in very good yields (60-80%). Preparation glycoside derivatives of flavanoids: (Formula Removed) Procedure: l).Acetic anhydride (2.5 ml) was added to a solution of anhydrous D- glucose (1.0 g, 5.55mmol) in 5 ml of pyridine and stirred at RT for 8 hrs. the solution was evaporated in vacuo, the syrupy residue dissolved in 25 ml of CHCh and washed with water, saturated Na2SO4 and evaporated in vacuo gives 2,3,4,6 penta-O-acyl-D-galacto pyronose (2) with out further purification the yield is 92%. 2).A solution of Hydrogen bromide in glacial acetic acid (40 %, 5ml) was added to a stirred solution of (2) (1.17g, 3.0 mmol) in 10 ml of acetic acid. Stirring was continued at RT for 8 hrs, kept away form direct sunlight. The reaction mixture is carefully poured in to 50 ml of ice water and extracted with three times with CHCb . The combine layers are washed with saturated NaaSCU solution and NaCl solution and evaporated in vaccuo and this yellow syrupy residue is dissolved in 5ml of ether and allowed to crystallize at 5°c and resultant compound was gives the aceto bromo galactose (3)yield was 72%. 3).Take the corresponding flavonoid (2.43 mmol) dissolved in acetone and add anhydrous K2CO3 (0.4g, 2.916 mmol) and stirrer for 15 min then add acetobromogalactose (3) (Ig, 2.43 mmol) and stirrer at RT for 3-4 hrs. After completion of reaction filter the reaction mixture and evaporated in vacuo, purify with column chromatography and yielded 5a and 5b 85-90%. 4).To a solution of 5a and 5b in methanol add methonolic KOH and stirred for 1-2 hrs and after completion of reaction, evaporate the methanol completely dissolved the reaction mixture in water and extracted with CHC13 two times and combine layers dried over Na2SO4 and evaporated in vacuo gives 6a and 6b in pure form without further purification, yield 95%. 6).Preparation of OA-5 Acid (7-O-glucoronide derivative of Oroxylin A): (Formula Removed) Procedure: Compound dissolved in methanolic KOH and reflux for l-2hrs. After completion of reaction (monitored by TLC), methanol completely dissolved the reaction mixture in water and extracted with ethyl acetate two times and combine layers dried over Na2SO4 and evaporated in vacuo gives corresponding acid on column chromotogarphy. Yield: 85%. Brief Description of the Drawings:- The invention is illustrated by the accompanying drawings where in Fig 1 represents formula of Oroxylin-A [5,7-Dihydroxy-6-methoxy-2-phenylchromen-4-one ] FIG:2 represents formula of Chrysin [5,7-dihydroxy-2-phenyl-chromen-4-one ] FIG:3 represents formula of Baicalein [5,6,7-trihydroxy-2-phenyl-chromen-4-one] FIG:4 represents formula of Methoxy chrysin [5-hydroxy-7-methoxy-2-phenyl-chromen-4-one ] FIG:5 represents formula of Oroxoloside methyl ester [3,4,5-trihydroxy-6-(6-methoxy- 4-oxo-2-phenyl-4-H-chromen-7-yoloxy) tetrahydro-pyran-2-carboxylicacid methyl ester ] FIG:6 represents formula of chrysin-7-O- methyl glycoside [3,4,5-trihydroxy-6-(4-oxo-2-phenyl-4-H-chromen-7-yoloxy) tetrahydro-pyran-2-carboxylicacid methyl ester ] FIG:7 represents formula of ORC-16 [Heptadecanoic acid 5-hydroxy-6-methoxy- 4-oxo-2-phenyl-4H-chromen-7-yl ester] FIG:8 represents formula of ORPM-1 [4-methyl-benzoic acid 5-hydroxy-6-methoxy-4-oxo-2-phenyl-4-H-chromen-7-yl ester] FIG:9 represents formula CPP-2 [5-Hydroxy-2-phenyl-7-(3-piperidin-l-yl-propoxy)- chromen-4-one] FIG: 10 represents formula of CHM-2 [5-Hydroxy-7-(3-morpholin-4-yl-propoxy)-2-phenyl chromen-4-one] FIG: 11 represents formula of CHN-2 [7-(3-Dimethyl amino-propoxy)-5-hydroxy-2-phenyl chromen-4-one] FIG: 12 represents formula of NMC-2 [5-Hydroxy-7-[3-(4-methyl-piperzin-l-yl]- propoxy)- 2-phenyl hromen-4-one] FIG: 13 represents formula of NMC-3 [5-Hydroxy-7-[4-(4-methyl-piperzin-l-yl]-butoxy)- 2- phenyl chromen-4-one] FIG: 14 represents formula of CHM-3 [5-Hydroxy-7-(4-morpholin-4-yl-butoxy)- 2-phenyl chromen-4-one] FIG: 15 represents formula of OAG [ 5-Hydroxy-6-methoxy-2-phenyl-7-(3,4,5-trihydroxy-6- hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one] FIG: 16 represents formula of CG [5-Hydroxy-2-phenyl-7-(3,4,5-trihydroxy-6- hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one] FIG: 17 represents formula of OA-5 Acid [3,4,5-Trihydroxy-6-(5-hydroxy-6-methoxy-4- oxo-2-phenyl-4H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid]. (Formula Removed) In another embodiment of the invention of Oroxylin A (Fig:l) obtained from Oroxylum indicum has the following spectrochemical and physical properties MP:231-232°C. 1R (KBr)vmax 3435, 2825, 1622, 1016 cm-'. *H NMR (200 MHz, CDC13+ MeOH-d4) (8) 7.82-7.86 (2H, m, H-2', 6'), 7.42-7.56 (3H, m, H-3', 4', 5'), 6.62 (IH, s, H-8), 6.58 (IH, s, H-3), 3.96 (3H, s, Ar-OMe). 13C NMR (50 MHz, DMSO d6) 8 163.37 (C-2), 104.46 (C-3), 182.31 (C-4), 152.64 (C-5), 130.80 (C-6), 157.62 (C-7), 94.49 (C-8), 152.79 (C- 9), 104.71 (C-10), 131.60 (C-1'), 126.42 (C-2'), 129.20 (C-3'), 132.06 (C-4'), 60.06 (OMe). EIMS:284 (M+, 100). In another embodiment of the invention of Chrysin (Fig : 2) obtained from Oroxylum indicum has the following spectralchemical and physical properties MP:285-286°C. IR (KBr)vmax 3450, 2925, 1626, 1024 cm'1. 'H NMR (400 MHz, CDC13+ MeOH-d4) (8) 7.82-7.92 (2H, m, H-2', 6'), 7.44-7.58 (3H, m, H-3', 4', 5'), 6.64 (IH, s, H-8), 6.44 (IH, s, H-3), 6.24 (IH, s, H-6). 13C NMR (50 MHz, DMSO d6) 8163.0 (C-2), 105.0 (C-3), 181.6 (C-4), 161.5 (C-5), 99.0 (C-6), 164.3 (C-7), 94.0 (C-8), 157.3 (C-9), 104.0 (C-10), 138.7 (C-1'), 126.1 (C-2'), 128.8 (C-3'), 131.6 (C-4'), 128.8 (C-5'), 126.0 (C-6'). EIMS:M+254. In another embodiment of the invention of Baicalein (Fig: 3) obtained from Oroxylum indicum has the following spectral chemical and physical properties MP:223-226°C. 'H NMR (400 MHz, CDC13+ MeOH-d4) (8) 7.82-7.98 (2H, m, H-2', 6'), 7.44-7.60 (3H, m, H-3', 4', 5'), 6.62 (IH, s, H-8), 6.58 (IH, s, H-3). 13C NMR (50 MHz, DMSO d6) 8162.9 (C-2), 104.5 (C-3), 182.1 (C-4), 147.0 (C-5), 129.3 (C-6), 153.7 (C-7), 94.0 (C-8), 149.9 (C-9), 104.3 (C-10), 131.0 (C-1'), 126.2 (C-2'), 129.0 (C-3'), 131.7 (C-4'), 129.0 (C-5' ),126.2 (C-6). EIMS:270 (M+, 100). In another embodiment of the invention of Methoxy chrysin (Fig :4) obtained from Oroxylum indicum has the following spectralchemical and physical properties MP:164°C. (KBr) vmax 3450, 2925, 1654, 1621, 1016 cm'1. 'H NMR (200 MHz, CDC13) (8)13.0(1 H, s, OH-5), 7.82-7.96 (2H, m, H-2', 6'), 7.44-7.60 (3H, m, H-3', 4', 5'), 6.62 ( IH, s, H-8), 6.60 (IH, s, H-3), 6.58 (IH, s, H-6), 3.96 (3H, s, OMe). 13C NMR (300 MHz, CDC13) (8)164.08 (C-2), 105.04 (C-3), 182.88 (C-4), 164.08 (C-5), 93.97 (C-6), 153.31 (C-7), 93.97 (C-8), 153.31(C-9), 105.50 (C-10), 130.96 (C-1'), 126.24 (C-2'), 128.88 (C-3'), 131.26 (C-4'), 128.88 (C-5'), 126.24 (C-6'), 60.63 (Ar-OMe).EIMS:192 (M+, 100). In another embodiment of the invention of Oroxyloside methyl ester (Fig :5) obtained from Oroxylum indicum has the following spectralchemical and physical properties MP:201°C. UV Jin,,* (MeOH)345, 285 nm. IR (KBr) vmax 3395, 2924, 1735 (ester-C=O), 1618 (-C=0), 1461, 1359, 1224, 1076 cm'1. 'H NMR (200 MHz, DMSO-d6) (8) 12.78 (IH, s, OH-5), 7.90-8.0 (2H, m, H-2', 6'), 7.48-7.60 (3H, m, H-3', 4', 5'), 6.84 (IH, s, H-8), 6.80(1H, s, H-3), 3.4-5.50 (m, sugar protons), 3.78 (3H, s, OMe), 3.82 (3H, s, Ar-OMe).13C NMR (300 MHz, DMSO-d6) (8) 163.72 (C-2), 104.95 (C-3), 182.37 (C-4), 152.52 (C-5), 132.04 (C-6), 156.08 (C-7), 94.07 (C-8), 152.17 (C-9), 106.12 (C-10), 130.59 (C-1'), 126.35 (C-2',6'), 129.03 (C-3',5'), 132.06 (C-4'), 99.49 (C-l"),75.60 (C-2"), 75.25 (C-3"), 72.77 (C-4"), 71.18 (C-5"), 168.96 (C-6"), 60.21 (Ar-OMe), 51.81 (OMe). EIMS: 475 (M++l, 100). In another embodiment of the invention of Chrysin-7-O- methyl glycoside (Fig :6) obtained from Oroxylum indicum has the following spectralchemical and physical properties MP:201°C. UV Xmax (MeOH)345, 285 nm. IR (KBr) vmax 3390, 2928, 1735 (ester-OO), 1610 (-C=0), 1465, 1345, 1210, 1055 cm'1. 'H NMR (200 MHz, DMSO-d6) (5) 12.70(1H, s, OH-5), 7.92-8.05 (2H, m, H-2', 6'), 7.45-7.56 (3H, m, H-3', 4', 5'), 6.80 (1H, s, H-8),6.74 (1H, s, H-6) 6.68(1H, s, H-3), 3.4-5.50 (m, sugar protons), 3.70(3H, s, OMe). 13C NMR (300 MHz, DMSO-de) (S) 162.65 (C-2), 104.64 (C-3), 181.97 (C-4), 152.05 (C-5), 98.56 (C-6), 155.60 (C-7), 94.23(C-8), 151.87 (C-9), 106.10 (C-IO), 131.59 (C-l'), 126.05 (C-2',6'), 129.15 (C-3',5'), 132.00 (C-4'), 99.43 (C-l"),75.45 (C-2"), 75.05 (C-3"), 72.54 (C-4"), 70.98 (C-5"), 168.90 (C-6"), 51.81 (OMe). EIMS: 445 (M++l) In another embodiment of the invention of synthetic analogues from oroxylin-A obtained from Oroxylum indicum as acyl derivatives namely 7-O-dodecyl oroxylin A (Fig:7) the following spectralchemical and physical properties MP :101.2° C; 'H NMR (300 MHz, CDC13) 8 12.82 (1H, s, OH-5), 7.88-7.92 (2H, m, H-2', 6'), 7.50-7.56 (3H, m, H-3', 4', 5'), 6.70 (1H, s, H-8), 6.64 (1H, s, H-3), 3.90 (3H, s, OMe), 2.62 (2H, t, H-2"), 1.60-1.80 (2H, m, H-3"), 1.22-1.40 (16H, brs, H-4"-H-l 1"), 084 (3H, t, H-12"). FABMS: 467 (M++l). In another embodiment of the invention of synthetic analogues from oroxylin-A obtained from Oroxylum indicum as acyl derivatives named 7-O- (p-methylbenzoyl) oroxylin A (Fig :8) the following spectralchemical and physical properties MP: 203° C, 'H NMR (300 MHz, CDC13) 8 12.82 (1H, s, OH-5), 8.46 (2H, d, J = 6Hz, H-2", 6"), 7.82-7.84 (2H, m, H-2', 6'), 7.50-7.58 (3H, m, H-3', 4', 5'), 7.36 (2H, d, J 6Hz, H-3", 5"), 6.90 (1H, s, H-8), 6.70 (1H, s, H-3), 3.96 (3H, s, OMe), 2.52 (3H, s, Ar-Me). FABMS: 429 (M++Na). In another embodiment of the invention of synthetic analogues from chrysin obtained from Oroxylum indicum as alkyl amino derivatives 7-O-propyl (piperidinyl) Chrysin (Fig: 9) the following spectral-chemical and physical properties: MP : 215° C , 'H NMR (300 MHz, CDC13) 8 12.50 (1H, s, OH-5), 7.82-7.86 (2H, m, H-2', 6'), 7.44-7.58 (3H, m, H-3', 4', 5'), 6.66(1 H, s, H-8), 6.58 (1H, s, H-3), 6.39 (1H, s, H-6), 4.16 (2H, t, H-l"), 2.38-2.58 (6H, m, H-2"', 6'" and H-3"), 1.98-2.08 (2H, m, H-2"), 1.58-1.60 (4H, m, H-3'", 5'"), 1.41-1.50 (2H, m, H-4'"). FABMS: 402(M++Na). In another embodiment of the invention of synthetic analogues from chrysin obtained from Oroxylum indicum as alkyl amino derivatives 7-O-propyl (morphinyl) chrysin (Fig: 10) the following spectralchemical and physical properties: MP:138° C, *H NMR (400 MHz, CDC13) 5 12.60 (IH, s, OH-5), 7.86-7.90 (2H, m, H-2', 6'), 7.50-7.62 (3H, m, H-3', 4', 5'), 6.64 (IH, s, H-8), 6.46 (IH, s, H-3), 6.38 (IH, s, H-6), 4.18 (2H, t, H-1"), 3.82 (4H, t, H-3"', 5'"), 2.40-2.60 (6H, m, H-2'", 6'", H-3"), 1.9-2.10 (2H, m, H-2"). FABMS: 382 (M++l). In another embodiment of the invention of synthetic analogues from chrysin obtained from Oroxylum indicum as alkyl amino derivatives 7-O-propyl (N, N-Dimethyl) chrysin (Fig: 11) the following spectralchemical and physical properties: MP 119-120° C , 'H NMR (400 MHz, CDC13) 8 12.72 (IH, s, OH-5), 7.82-7.86 (2H, m, H-2', 6'), 7.50-7.58 (3H, m, H-3', 4', 5'), 6.64 (IH, s, H-8), 6.48 (IH, s, H-3), 6.38 (IH, s, H-6), 4.10 (2H, t, H-1"), 2.42 (2H, H-3"), 2.22 (6H, s, 2xMe), 1.98-2.02 (2H, m, H-2"). FABMS: 340 (M++l) In another embodiment of the invention of synthetic analogues from chrysin obtained from Oroxylum indicum as alkyl amino derivatives 7-O-propyl (N-methyl piperizinyl) chrysin (Fig: 12) the following spectralchemical and physical properties: MP:128-130° C, 'H NMR (400 MHz, CDC13) 8 12.70 (IH, s, OH-5), 7.84-7.86 (2H, m, H-2', 6'), 7.46-7.58 (3H, m, H-3', 4', 5'), 6.64(1H, s, H-8), 6.52(1H, s, H-3), 6.18 (IH, s, H-6), 4.12 (2H, t, H-1"), 2.40-2.60 (9H, m, H-3'", 5"', H-3" and H-2'", 6'"), 2.30 (3H, s, Me), 1.90-2.10 (2H, m, H-2"). FABMS: 395 (M++l). In another embodiment of the invention of synthetic analogues from chrysin obtained from Oroxylum indicum as alkyl amino derivatives 7-O-butyl (N-methyl piperizinyl) chrysin (Fig: 13) the following spectralchemical and physical properties: MP :80° C, *H NMR (300 MHz, CDC13) 8 12.64 (IH, s, OH-5), 7.76-7.86 (2H, m, H-2', 6'), 7.40-7.58 (3H, m, H-3', 4', 5'), 6.58 (IH, s, H-8), 6.40 (IH, s, H-3), 6.30 (IH, s, H-6), 4.0 (2H, t, H-1"), 2.80-3.0 (10H, m, H-2'", 6"', H-3'", 5'", H-4"), 2.58 (3H, s, Me), 1.6-1.82 (4H, m, H-2", 3"). FABMS: 43l(M++Na). In another embodiment of the invention of synthetic analogues from chrysin obtained from Oroxylum indicum as alkyl amino derivatives 7-O-butyl (morphinyl) chrysin Chrysin (Fig: 14) the following spectralchemical and physical properties MP :130° C, 'H NMR (300 MHz, CDC13) 8 12.38 (IH, s, OH-5), 7.80-7.88 (2H, m, H-2', 6'), 7.50-7.58 (3H, m, H-3', 4', 5'), 6.72 (IH, s, H-8), 6.62 (IH, s, H-3), 6.40 (IH, s, H-6), 4.10 (2H, t, H-1"), 3.70-3.76 (4H, m, H-3'", 5'"), 2.40-2.50 (6H, m, H-2'", 6'", H-4"), 1.80-2.0 (2H, m, H-3"), 1.60-1.80 (2H, m, H-2"). FABMS: 396 ( M++l). In another embodiment of the invention of synthetic analogues from oroxylin A obtained from Oroxylum indicum as glycoside derivatives OAG (Fig :15) the following spectralchemical and physical properties: 'H NMR (200 MHz, CDC13 + MeOH- d4) 812.78 (1H, s, OH-5), 7.80-7.86 (2H, m, H-2', 6'), 7.42-7.56 (3H, m, H-3', 4', 5'), 6.83 (1H, s, H-8), 6.50(1 H, s, H-3), 3.4-5.50 (m, sugar protons), 3.78 (3H, s, OMe), 3.92-3.96 (2H, d ). In another embodiment of the invention of synthetic analogues from Chrysin obtained from Oroxylum indicum as glycoside derivatives CG (Fig : 16) the following spectralchemical and physical properties: 'H NMR (200 MHz, CDC13 + MeOH- d4) 512.78 (1H, s, OH-5), 7.82-7.98 (2H, m, H-2', 6'), 7.44-7.60 (3H, m, H-3', 4', 5'), 6.63 (1H, s, H-8), 6.48(1H, s, H-3), 6.24 (1H, s, H-6), 3.4-5.50 (m, sugar protons), 3.90-3.93 (2H, d). In another embodiment of the invention of synthetic analogues from oroxyloside methyl ester obtained from Oroxylum indicum as glycoside derivative OA-5 Acid (Fig :17) the following spectralchemical and physical properties: *H NMR (200 MHz, MeOH-d,0 (8) 12.70 (1H, s, OH-5), 7.94-8.05 (2H, m, H-2', 6'), 7.40-7.55 (3H, m, H-3', 4', 5'), 6.80(1H, s, H-8), 6.57(1H, s, H-3), 3.4-5.50 (m, sugar protons), 3.82 (3H, s, Ar-OMe). The following examples are given by the way of illustration and therefore should not be construed to limit the scope of the invention Example 1: Experimental protocol: process of isolation of Oroxylin A, Chrysin and Baicalein. The dried powdered stem bark (200g) was first defatted with petrol in a soxlet apparatus. The bright yellow coloured powdered solid was obtained after the filtration of the hexane extract. The solid (2g) was chromatographed over silica gel (60-120 mesh), 3.5cm dia column loaded to a height of 60cm. The column was successively eluted with l%methanol in chloroform to afford Oroxylin-A. The yield of Oroxylin-A is around 1.2g. Further elution of the column with 2%methanol in chloroform afforded chrysin. The yield of Chrysin is around 0.2g. Further elution of the column with 3%methanol in chloroform afforded Baicalein. The yield of Baicalein is around 0.5g. Process of isolation of Methoxy chrysin , Oroxyloside methyl ester and chrysin-7-O-methyl glycoside: The dried powdered stem bark (200g) was successively extracted with hexane and acetone . The acetone extract on evaporation afforded a dark brown colored residue (3g). The residue was chromatographed over silica gel (60-120mesh), 3.5cm dia column loaded to a height 60cm. In addition to oroxylin A, Chrysin and Baicalein two more compounds namely Methoxychrysin, Oroxyloside methyl ester and chrysin-7-O- methyl gluconide were isolated as follows. The column was successively eluted with l%methanol in chloroform to afford Oroxylin-A. The yield of Oroxylin-A is around 0.2g. Further elution of the column with 2%methanol in chloroform afforded chrysin. The yield of Chrysin is around 0.25g. Further elution of the column with 3%methanol in chloroform afforded Baicalein. The yield of Baicalein is around 1.5g. Further elution of the column successively with 4%methonal in chloroform afford Methoxy chrysin. The yield of methoxy chrysin is around 0.5g. Further elution of the column with 5% methonal in chloroform afford Oroxyloside methyl ester. The yield of Oroxyloside methyl ester is around 0.4g. Further evolution of the column with 7 % methanol in chloroform afford chrysin-7-O- methyl gluconide. The yield of the chrysin-7-O- methyl gluconide is around 0.3g. All the above compounds were isolated in 95% purity. The spectrochemical and physical properties of the all the above compounds are discussed earlier. Further all the synthetic analogues preparation and yields were discussed in earlier procedures. Example 2: Experimental method for gastric ulcer The compounds taken under study for antigastric ulcer screening by four different models were selected using experimental albino rats : 1. Aspirin induced gastric ulceration 2. Pylorus ligated gastric ulceration 3. Ethanol induced gastric ulceration 4. Stress induced gastric ulceration The commercially available drug ranitidine (sigma), Omeprazole (sigma) and sucralfate (Merck) were used as reference standard in experimental models. The Tween- 80 (SD fine chemicals) was used as vehicle for the administration of the drug, which is used as control. The results obtained are presented in the following tables. 2.1 Acetyl salicylic acid induced ulcer: The antiulcer activity of the compounds under taken was studied. The animals were divided into 20 groups of 6 animals each. Group 1 received the vehicle Tween 80 (1%, 1 ml) which served as the control. Group 2 received ranitidine at a dose of 50-mg/kg body weight, which served as standard for comparison. Group 3 to 20 at a dose of 25 mg / kg body weight. Rats were administered per orally with a daily dose of the compounds and the drug ranitidine for a period of five days and then fasted for 24 hours. The narcotizing agent acetyl salicylic acid (aspirin) at a dose of 200 mg /kg body weight was administered as a suspension in tween-80 (1%), SOmin after the drug administration each day. All drugs were administered orally on the 6th day after the last administration of the drugs and the ulcer inducing agent aspirin, the rats were killed by cervical dislocation and their stomach were opened along the greater curvature and washed with luke warm saline and examined under a dissecting microscope. The ulcer index was calculated for each stomach. The results are tabulated below in table no. 1. Table: 1 Ulcer protective effect of samples in acetyl salicylic acid induced gastric lesions(Table Removed) Baicalein = (Fig: 3) ORC-16 = (Fig:7) NMC-2 = (Fig: 12) CHN-2 = (Fig: 11) CHM-3 = (Fig: 14) OA-G= (Fig: 15) CG = (Fig:16) OA-5 = Oroxyloside methyl ester (Fig :5) Oroxylin A = (Fig: 1) Chrysin = (Fig : 2) Methoxy chrysin = (Fig :4) ORPM-1 = (Fig:8) NMC-3 = (Fig: 13) CHM-2 = (Fig: 10) CPP-2 = (Fig: 9) OA-5 acid = (Fig: 17) CGL = (Fig :6) 2.2 Cold restraint induced ulcers The antiulcer activity of the compounds was studied. The animals were divided into 21 groups of 7 animals each. Group 1 received the vehicle Tween 80 (1%, 1 ml) which served as the control. Group 2 received ranitidine at a dose of 50-mg/kg body weight, which served as standard for comparison. Group 3 to 21 at a dose of 25 mg / kg body weight. Animals were deprived of food 48 hours before the experiment. The water was allowed for free access. Rats were administered per orally with compounds and the drug ranitidine. The water was removed 1 hour before restraint and exposed to a temparature of 4°C for 2 hours. Two hours after stress, the animals were sacrificed. The stressed animals were opened along the greater curvature and the severity of gastric ulcer was assessed in terms of mean ulcer index. Results are tabulated below in table no.2. Table: 2 Effect of samples on gastric ulceration in cold restraint rats(Table Removed) 2.4 Pylorus ligated ulcers The animals were divided into 19 groups of 6 animals each. Animals were deprived of food for 48 hours but had free access to water. Group 1 received the vehicle Tween 80 (1%, 1 ml) which served as the control. Group 2 received ranitidine at a dose of 50-mg/kg-body weight, which served as standard for comparison. Group 3 to 20 received at a dose of 25 mg / kg body weight. After one hour of administration of drug the stomach was ligated at the pylorus under ether anesthesia. 4hours after pylorus ligation, the animals were sacrificed and the contents drained and centrifuges at 5000 rpm for lOminutes. Aliquots of supernatant were used for determination of total acid by titrating with 0.0IN NaOH using topfers reagent and phenolphthalein indicators. Results are tabulated below in table no.4 Table: 4 Antisecretory and ulcer protective effect of samples in Pylorus ligated rats(Table Removed) 2.5 Acetyl salicylic acid induced ulcer: The antiulcer activity of the compounds was studied. The animals were divided into 19 groups of 6 animals each . Group 1 received the vehicle Tween 80 (1%, 1 ml) which served as the control. Group 2 received ranitidine at a dose of 50-mg/kg-body weight, which served as standard for comparison. Group 3 to 8 at a dose of 50, 25, 15, 10 and 5 mg / kg body weight respectively. Rats were administered per orally with a daily dose of the compounds and the drug ranitidine to respective groups for a period of five days and then fasted for 24 hours. The narcotizing agent acetyl salicylic acid (aspirin) at a dose of 200 mg /kg body weight was administered as a suspension in tween-80 (1%), 30min after the drug administration each day. All drugs were administered orally on ht e6th day after the last administration of the drugs and the ulcer inducing agent aspirin, the rats were killed by cervical dislocation and their stomach were opened along the greater curvature and washed with luke warm saline and examined under a dissecting microscope. The ulcer index was calculated for each stomach. Table: 5 Ulcer protective effect of OA - 5 in acetyl salicylic acid induced gastric lesions(Table Removed) 2.6 Cold restraint induced ulcers The antiulcer activity of the compounds was studied. The animals were divided into 8 groups of 6 animals each . Group 1 received the vehicle Tween 80 (1%, 1 ml) which served as the control. Group 2 received ranitidine at a dose of 50-mg/kg body weight, which served as standard for comparison. Group 3 to 8 at a dose of 50, 25, 15, 10 and 5 mg / kg body weight respectively. Animals were deprived of food 48 hours before the experiment. The water was allowed for free access. Rats were administered per orally with compounds and the drug ranitidine. The water was removed 1 hour before restraint and exposed to a temperature of 4°C for 2 hours. Two hours after stress, the animals were sacrificed. The stressed animals were opened along the greater curvature and the severity of gastric ulcer was assessed in terms of mean ulcer index. Table: 6 Effect of OA - 5 on gastric ulceration in cold restraint rats(Table Removed) 2.7 Ethanol induced ulcers The animals were divided into 9 groups of 6 animals each. Animals were deprived of food for 48 hours but had free access to water. Group 1 received the vehicle Tween 80 (1%, 1 ml) which served as the control. Group 2 received ranitidine at a dose of 50-mg/kg-body weight, which served as standard for comparison. Group 3 to received Omeprazole at a dose of 30-mg/kg body weight, which served as standard for comparison. Group 4 received sucralfate at a dose of 400-mg/kg body weight, which served as standard for comparison. Group 5 to 9 received at a dose of 50, 25, 15, 10 and 5 mg / kg body weight respectively. Lesions were induced 1 hour after ethanol challenge animals. The stomach was ligated at the pylorus under ether anesthesia. 4hours after pylorus ligation, the animals were sacrificed and the contents drained and centrifuges at 5000 rpm for lOminutes. Aliquots of supernatant were used for determination of total acid by titrating with 0.0IN NaOH using topfers reagent and phenolphthalein indicators. Table: 7 Ulcer protective effect of OA - 5 on ethanol induced gastric ulcers(Table Removed) 2.4 Pylorus ligated ulcers The animals were divided into 7 groups of 6 animals each. Animals were deprived of food for 48 hours but had free access to water. Group 1 received the vehicle Tween 80 (1%, 1 ml) which served as the control. Group 2 received ranitidine at a dose of 50-mg/kg-body weight, which served as standard for comparison. Group 3 to 7 received at a dose of 50, 25, 15, 10 and 5 mg / kg body weight respectively. After one hour of administration of drug the stomach was ligated at the pylorus under ether anesthesia. 4hours after pylorus ligation, the animals were sacrificed and the contents drained and centrifuges at 5000 rpm for lOminutes. Aliquots of supernatant were used for determination of total acid by titrating with 0.0 IN NaOH using topfers reagent and phenolphthalein indicators Table: 8: Antisecretory and ulcer protective effect of OA - 5 in Pylorus ligated rats (Table Removed) WE CLAIM 1. A process for the isolation of Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O- methyl glycoside as anti ulcer compounds form Oroxylum indicum the said process comprising the steps of: (a) extracting dried stem bark of Oroxylum indicum with hexane by using soxlet apparatus (b) filtering the extract to separate out solids (c) subjecting the residue to a first elution with 1% methanol in chloroform to obtain Oroxylin A and (d) subjecting the residue of step c to a second elution with 2% methanol in chloroform to obtain Chrysin and (e) subjecting the residue of step d to a third elution with 3% methanol in chloroform to obtain Baicalein. 2. A process for the isolation of Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O- methyl glycoside as anti ulcer compounds form Oroxylum indicum the said process comprising the following steps a) extraction with acetone of the hexane extracted material of claim 1 to obtain a residue b) subjecting the residue of step (a) to a first elution with 1% methanol in chloroform to obtain Oroxylin A and c) subjecting the residue of step b to a second elution with 2% methanol in chloroform to obtain Chrysin and d) subjecting the residue (step c) to a third elution with 3% methanol in chloroform to obtain Baicalein e) subjecting the residue (step d) to fourth elution with about 4 % methanol in chloroform to obtain Methoxy chrysin f) subjecting the residue (step e ) to a fifth elution with 5%methanol in chloroform to obtain Oroxyloside methyl ester g) subjecting the residue (step f ) to a sixth elution with 7% methanol in chloroform to obtain chrysin-7-O- methyl glycoside. 3. A process as claimed in claim 1-2, wherein the compounds obtained are represented by the group of following compounds: Fig l: Oroxylin-A [5,7-Dihydroxy-6-methoxy-2-phenylchromen-4-one ]; Fig2: [5,7-dihydroxy-2-phenyl-chromen-4-one ]; Fig.3: [5,6,7-trihydroxy-2-phenyl-chromen-4-one] (Baicalein) Fig.4: Methoxy chrysin [5-hydroxy-7-methoxy-2-phenyl-chromen-4-one ]; Fig.5: Oroxoloside methyl ester [3,4,5-trihydroxy-6-(6-methoxy- 4-oxo-2-phenyl- 4-H-chromen-7-yoloxy) tetrahydro-pyran-2-carboxylicacid methyl ester]; Fig 6: chrysin-7-O- methyl glycoside [3,4,5-trihydroxy-6-(4-oxo-2-phenyl-4-H- chromen-7-yoloxy) tetrahydro-pyran-2-carboxylicacid methyl ester ]; 4. A process for the isolation of Oroxylin A, Chrysin, Baicalein, methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O- methyl glycoside from Oroxylum indicum substantially as herein described with reference to the examples accompanying this specification.

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