Title of Invention	"A PROCESS FOR PREPARING A 2-(N-METHYL-N-METHANESULFONYLAMINO)PYRIMIDINE COMPOUND"
Abstract	A process for preparing a 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound having the formula (3):

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The present invention relates to a process for preparing a 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound. The present invention relates to the preparation of aminopyrimidine compounds having the following formula (8): (Formula Removed) [in the formula (8), R is a hydrocarbyl group, and each of R1 and R2 independently is a hydrogen atomy an alkyl group, an alkylsulfonyl group, or an arylsulfonyl group], more particularly to the preparation of a 2- (N-msthyl-N-methanesulfonylamino)pyrimidine compound having the following formula (3): (Formula Removed) wherein R represents a hydrocarbyl group. BACKGROUND OF THE INVENTION Bioorg. Med. Chem., 5, 437(1997) describes that the 2-{N-methyl-N-methanesulfonylamino)pyrimidine compound is employable as an intermediate compound for producing a cholesterol reducing agent (HMG-CoA reductase inhibitor: S-4522) having the following formula: (Formula Removed) and which is now generally known as the calcium salt of rosuvastatin or rosuvastatin calcium. WO 01/04100 describes a process for preparing the 2-(N-methyl-N-methanesulfonylamino) pyrimidine compound which comprises the steps of: reacting methyl isobutyrylacetate with 4-fluoro-benzonitrile to produce methyl 2- [1-amino-l-(4-fluorophenyl) methylene] -4-methyl-3-oxopentanate; and reacting the 2-[1-amino-l-(4-fluorophenyl)methylene] -4-methyl-3-oxopentanate with N-cyano-N-methyl-methanesulfonamide which is obtained by reaction between N-methylmethanesulfonamide and cyanogen chloride, to produce 4- (4-fluorophenyl) -6-isopropyl-5-methoxycarbonyl-2-(N-methanesulf onyl -N-methylamino) pyrimidine. It is described that the total yield (based on the amount of methyl isobutyrylacetate) is 45.5%. It appears that the process described in WO 01/04100 is disadvantageous for the industrial preparation, because the yield is not high and it is necessary to employ toxic cyanogen chloride as one of the starting compounds. Accordingly, it is an object of the invention to provide a novel process for preparing a 2- (N-methyl-N-methanesulfonylamino) pyrimidine or an analogous amino-pyrimidine compound thereof, more particularly to provide a novel process which provides the compound more conveniently and/or without employing a toxic compound and/or provides the compound in high yield and/or high purity. It is another object of the invention to provide a novel process for preparing a 2- (N-methyl-N-methanesul-fonylamino) pyrimidine compound or an analogous amino-pyrimidine compound thereof which is favorably employable in the industrial preparation. SUMMARY OF THE INVENTION The present invention resides in a process for preparing a 2-(N-methyl-N-methanesulfonylamino) pyrimidine having the formula (3) : (Formula Removed) [R is a hydrocarbyl group] , which comprises the steps of: reacting a hydroxypyrimidine compound having the formula (1): (Formula Removed) in which R is the same as above, with an organic sulfonyl halide having the formula (2) in which R1 is a hydrocarbyl group and X is a halogen atom, or an organic sulfonic anhydride having the formula (2a): (Formula Removed) in which R' is the same as above, and reacting the resulting reaction product with N-meth-yl-N-methanesulf onamide. The invention also resides in a hydroxypyrimidine compound having the above-identified formula (1) . The invention further resides in a method for preparing a hydroxypyrimidine compound of the formula (1) , which comprises oxidizing a dihydropyrimidinone compound having the formula (4) : (Formula Removed) wherein R is a hydrocarbyl group. The invention further resides in a dihydropyrimidinone compound having the formula (4) . The invention furthermore resides in a method for preparing a dihydropyrimidinone compound of the formula (4), which comprises reacting an isobutyrylacetate ester having the formula (5): (Formula Removed) in which R is a hydrocarbyl group, with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt. The invention furthermore resides in a method for preparing an aminopyrimidine compound having the formula (8) : (Formula Removed) wherein R is a hydrocarbyl group, and each of R1 and R2 independently is hydrogen atom, an alkyl group, an alkyl-sulfonyl group, or an arylsulfonyl group, which conprises reacting a 2-substituted pyrimidine compound having the formula (6): (Formula Removed) wherein R is the same as above, and X is a halogen atom or an organic sulfonyloxy group, with an amine compound having the formula (7) : (Formula Removed) wherein each of R1 and R2 is the same as above. The invention furthermore resides in a halogeno pyrimidine compound having the formula (9): (Formula Removed) wherein R is a hydrocarbyl group, and Hal is a halogen atom. The invention furthermore resides in a method for preparing the halogenopyrimidine compound of the formula (9) , which comprises reacting a hydroxypyrimidine compound of the aforementioned formula (1) with a halogenat-ing agent. The invention furthermore resides in an organic sulfonyloxypyrimidine compound having the formula (10) : (Formula Removed) wherein each of R and R1 independently is a hydrocarbyl group. The invention furthermore resides in a method for preparing an organic sulfonyloxypyrimidine compound of the formula (10), which comprises reacting a hydroxy-pyrimidine compound of the aforementioned formula (1) with an organic sulfonyl halide having the formula (2) : (Formula Removed) wherein R1 is a hydrocarbyl group, and X is a halogen atom, or an organic sulfonic anhydride having the formula (2a) : (Formula Removed) in which R' is the same as above. The invention furthermore resides in a process for preparing a 2-(N-methyl-N-methanesulfonylamino)pyrimidine of the formula (3) which comprises the steps of: (I) reacting an isobutyrylacetate ester of the formula (5) with 4-fluorobenzaldehyde and urea in the .presence of a protonic compound and a metal salt; (II) oxidizing the reaction product of the step (I) ,- (III) reacting the oxidation product of the step (II) with an organic sulfonyl halide of the formula (2) or an organic sulfonic anhydride of the formula (2a) ,- and (IV) reacting the reaction product of the step (III) with N-methyl-N-methanesulf onamide. In the above-mentioned process, the steps (III) and (IV) can be carried out continuously in the same reaction mixture. DETAILED DESCRIPTION OF THE INVENTION -The representative process for the preparation of 2-(N-methyl-N-methanesulfonylamino)pyrimidine of the formula (3) according to the present invention is schematically illustrated as follows: (Formula Removed) Each step in the above-illustrated reaction scheme is described below in more detail. Step (I) In the step (I), an isobutyrylacetate ester of the following formula (5): (Formula Removed) [R is a hydrocarbyl group] . is reacted with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt. The hydrocarbyl group (i.e., hydrocarbon group) represented by R in the formulas of the compounds involved in the reactions of the invention can be an alkyl group such as methyl, ethyl, propyl, butyl, pentyl, hex-yl, heptyl, octyl, nonyl, or decyl, more particularly an alkyl group having 1-6 carbon atoms and especially an alkyl group having 1-4 carbon atoms; a cycloalkyl group such as cyclopropyl, cyclobutyl, cyclopentyl, or cyclo-hexyl; an aralkyl group such as benzyl, phenylethyl, or phenylpropyl; or an aryl group such as phenyl or methyl-phenyl. The hydrocarbyl group can take any isomer configurations such as normal, iso, and tertiary. The hydrocarbyl group can have one or more substituents, provided that the substituents do not disturb the reaction involved. The protonic compound can be an inorganic acid or its salt such as hydrochloric acid, sulfuric acid, potassium hydrogensulfate, sodium hydrogen sulfate, nitric acid, or phosphoric acid; an organic sulfonic acid such as methanesulfonic acid, ethanesulfonic acid, benzenesul-fonic acid, p-toluenesulfonic acid, or p-bromobenzene-sulfonic acid; an organic carboxylic acid such as acetic acid, propionic acid, butyric acid, or benzoic acid; an alcohol such as methanol, ethanol, or propanol. Preferred are protonic acids such as hydrochloric acid, sul-furic acid, p-toluenesulfonic acid, and acetic acid. Most preferred is sulfuric acid. The protonic compounds can be employed singly or in combination. The protonic compound can be employed in an amount of, preferably, 0.01 to 3 mol., more preferably 0.1 to 1 mol., per one mol. of the isobutyrylacetate ester. The metal salt employed in the reaction can be copper (I) chloride, copper(II) chloride, copper(II) acetate, iron(II) chloride, iron(III) chloride, aluminum chloride, nickel(II) bromide, tin(IV) chloride, titanium tetrachlo-ride,'or magnesium bromide. Preferred are copper(I) chloride, copper(II) chloride, iron(III) chloride and nickel(II) bromide. Most preferred is copper(I) chloride. The metal salts may contain water of crystallization. The metal salts can be employed singly or in combination. The metal salt can be employed in an amount of, preferably, 0.001 to 5 mol., more preferably 0.01 to 0.1 mol., per one mol. of the isobutyrylacetate ester. The 4-fluorobenzaldehyde can be employed in an amount of, preferably, 0.5 to 10 mol., more preferably 0.9 to 1.1 mol., per one mol. of the isobutyrylacetate ester. The urea can be employed in an amount of, preferably, 0.5 to 10 mol., more preferably 1.5 to 2 mol., per one mol. of the isobutyrylacetate ester. The reaction can be performed in the presence or absence of a solvent. There are no specific limitations with respect to the solvent employed, so far as the solvent does not disturb the desired reaction. Examples of the employable solvents include alcohols such as methanol, ethanol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, sec-butyl alcohol, and t-butyl alcohol; ethers such as diethyl ether, diisopro- pyl ether, tetrahydrofuran, and dimethoxyethane; nitriles such as acetonitrile, propionitrile, butyronitrile, and isobutyronitrile; halogenated aliphatic hydrocarbons such as dichloromethane, dichloroethane, chloroform, and carbon tetrachloride; aromatic hydrocarbons such as benzene, toluene, and xylene; halogenated aromatic hydrocarbons such as chlorobenzene; and nitrated aromatic hydrocarbons such as nitrobenzene. Preferred are methanol, ethanol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, di-isopropyl ether, tetrahydrofuran, dimethoxyethane, acetonitrile, butyronitrile, isobutylonitrile, dichloromethane, dichloroethane, chloroform, toluene, xylene, and chlorobenzene. Especially preferred are methanol, ethanol, and isopropyl alcohol. The solvents can be employed singly or in combination. The solvent can be employed in an amount of, preferably 0.1 to 10 liters, more preferably 0.3 to 2 liters, per one mole of the isobutyrylacetate ester. The amount may vary depending on homogeneity and dispersability of the reaction mixture. The reaction can be conducted by reacting the isobutyrylacetate ester, 4-fluorobenzaldehyde, and urea, in a solvent in the presence of a protonic compound and a metal salt under inert gas atmosphere. The reaction can be carried out at a temperature of, preferably -10 to 200°C, more preferably 30 to 100°C. There are no specific limitations with respect to the surrounding pressure. The resulting product of the reaction, that is, a dihydropyrimidinone compound of the formula (4) , can be isolated and purified according to the conventional procedures such as distillation, crystallization, recrystal-lization, and column chromatography. Step (II) In the step (II) , a dihydropyrimidinone compound of the formula (4), that is, the reaction product ot the step (I) , is oxidized to give a hydroxypyrimidine compound of the formula (1) . The oxidation (or dehydrogenation oxidation) can be performed in various conventional manners. Preferred is oxidation utilizing nitric acid, because this oxidation procedure is easily carried out and the post-treatment of the reaction product is easy. The nitric acid can be employed in an amount of, preferably 1 to 20 mol., more preferably 3 to 15 mol., per one mole of the dihydropyrimidinone compound of the formula (4). The nitric acid of a concentration of, preferably 40 to 80%, more preferably 50 to 70%, can be preferably employed. The oxidation can be performed in the presence or absence of a solvent. There are no specific limitations with respect to the solvent employed, so far as the solvent does not disturb the desired reaction. Examples of the preferred solvents include carboxylic acids such as acetic acid, propionic acid, and butyric acid. The solvents can be employed singly or in combination. The solvent can be employed in an amount of, preferably 0.1 to 7 mL, more preferably 0.5 to 3 mL, per 1 g of the dihydropyrimidinone compound. The amount may vary depending on homogeneity and dispersability of the reaction mixture. The oxidation can be conducted by reacting the dihydropyrimidinone compound and nitric acid in a solvent under inert gas atmosphere. The oxidation can be carried out at a temperature of, preferably -10 to 100°C, more preferably 0 to -50°C. There are no specific limitations with respect to the surrounding pressure. A reaction initiator such as sodium nitrite may be incorporated into the reaction system to accelerate the oxidation rate. The resulting product of the reaction, that is, the hydroxypyrimidine compound of the formula (1) , can be isolated and purified according to the conventional pro- cedures such as distillation, crystallization, recrystal-lization, and column chroma tography. Steps (III) and (IV) In the steps (III) and (IV) , a hydroxypyrimidine compound of the formula (1) , that is, the reaction product of the step (II) , is reacted with an organic sulfonyl halide of the formula (2): R'SO2X (2) or an organic sulfonic anhydride of the formula (2a) : (R'S02)20 (2a) and reacting the resulting reaction product with N-meth-yl-N-methanesulf onamide. In the formulas (2) and (2a) , R1 is a hydrocarbyl group which can have one or more substituents. Examples of the hydrocarbyl groups include alkyl groups such as methyl, ethyl, propyl, butyl, pentyl, heptyl, octyl, nonyl, and decyl, more particularly an alkyl group having 1-6 carbon atoms and especially an alkyl group having 1-4 carbon atoms; fluorinated alkyl groups such as tri-fluoromethyl, nonafluorobutyl, tridecafluorohexyl, hepta-decafluorooctyl, and uncosaf luorodecyl / cycloalkyl groups such as cyclopropyl, cyclobutyl, cyclopentyl, and cyclo-hexyl/ aralkyl groups such as benzyl, phenylethyl, and phenylpropyl; and aryl groups, including unsubstituted and substituted phenyl or naphthyl groups, such as phe-nyl, naphthyl, tolyl, xylyl, mesityl, triisopropylphenyl, methoxyphenyl, chlorophenyl, and nitrophenyl. Thus, the hydrocarbyl group can have one or more substituents, provided that the substituents do not disturb the reaction involved. The hydrocarbyl group can take any isomer con- figurations such as normal, iso, and tertiary. A particularly suitable value for R1 when it is aryl includes, for example, a phenyl or naphthyl group (particularly phenyl) which is unsubstituted or bears 1, 2 or 3 substi-tuents. The substituents may be independently selected from, for example, alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halogeno, and nitro. In the formula (2) , X is a halogen atom such as fluorine, chlorine, bromine, and iodine. Examples of the sulfonyl halides include methane-sulfonyl fluoride, me thane sulfonyl chloride, ethanesul-fonyl chloride, 1-propanesulfonyl chloride, 2-propane-sulfonyl chloride, trifluoromethanesulfonyl fluoride, trifluoromethanesulfonyl chloride, nonafluorobutane-sufonyl fluoride, tridecafluorohexanesulfonyl fluoride, heptadecafluorooctanesulfonyl fluoride, uncosafluoro-decanesulfonyl fluoride, benzenesulfonyl chloride, 1-naphthalenesulfonyl chloride, 2-naphthalenesulfonyl chloride, p-toluenesulfonyl fluoride, p-toluenesulfonyl chloride, 2,4, 6-trimethylbenzenesulf onyl chloride, 2,4,6-tri-isopropylbenzenesulfonyl chloride, p-tnethoxybenzenesul-fonyl chloride, p-chlorobenzenesulfonyl chloride, and 2-nitrobenzenesulfonyl chloride. Preferred are trifluoromethanesulfonyl fluoride, benzenesulfonyl chloride, 1-naphthalenesulfonyl chloride, 2-naphthalenesulfonyl chloride, p-toluenesulfonyl chloride, 2,4,6-trimethylbenzenesulf onyl chloride, 2,4,6-triisopropylbenzenesulfonyl chloride, p-methoxybenzenesulfonyl chloride, and p-chlorobenzenesulfonyl chloride. Particularly preferred are p-toluenesulfonyl chloride, 2,4, 6-trimethylbenzenesulf onyl chloride, 2,4,6-trii sopropylbenzenesulfonyl chloride, and p-methoxybenzenesulfonyl chloride. Examples of the sulfonic anhydrides include methane-sulfonic anhydride, trifluoromethanesulfonic anhydride, benzenesulfonic anhydride, and p-toluenesulfonic anhydride. Preferred are trifluoromethanesulfonic anhydride, benzenesulfonic anhydride, and p-toluenesulfonic anhydride. Particularly preferred are trifluoromethanesul-fonic anhydride and p-toluenesulfonic anhydride. The sulfonyl halide or sulfonic anhydride can be employed in an amount of, preferably 0.1 to 20 mol., more preferably 0.5 to 5 mol., most preferably 1 to 2 mol., per one mole of the hydroxypyrimidine compound. In the subsequent step, N-methylmethanesulfonamide can be employed in an amount of, preferably 0.1 to 30 mol., more preferably 1 to 5 mol., per one mol. of the hydroxypyrimidine compound. The reactions of the steps (III) and (IV) can be preferably performed in the presence of a base. Examples of the bases include alkali metal carbonates such as sodium carbonate and potassium carbonate; alkali metal hydrogencarbonates such as sodium hydrogencarbonate,-alkali metal hydroxides such as lithium hydroxide, sodium hydroxide and potassium hydroxide/ alkali metal alkoxides such as sodium methoxide, sodium t-butoxide, potassium t-butoxide, and sodium t-pentoxide; and tertiary amines such as triethylamine, triisopropylamine, diisopropyl-ethylamine, and pyridine. Preferred are sodium carbonate, potassium carbonate, potassium t-butoxide, sodium t-pentoxide, triethylamine, and pyridine. Particularly preferred are potassium carbonate, sodium t-pentoxide, and triethylamine. Most preferred are potassium carbonate and sodium t-pentoxide. The bases can be employed singly or in combination. The base can be employed in an amount of, preferably 0.1 to 30 mol., more preferably 1 to 5 mol., per one mol. of the hydroxypyrimidine compound. The whole amount of the base can be incorporated in the reaction system before the reaction begins, or the base can be portionwise added to the reaction system after the reaction begins. The reaction can be performed in the presence or absence ot a solvent. There are no specific limitations with respect to the solvent, so far as the solvent does not disturb the reaction. Examples of the solvents include water; ketones such as acetone, methyl ethyl ke-tone, and diethyl ketone; ethers such as diethyl ether and tetrahydrofuran; esters such as ethyl acetate, propyl acetate, and butyl acetate; nitriles such as acetonitrile and propionitrile; amides such as N,N-dimethylformamide and N-methylpyrrolidone; sulfoxides such as dimethylsulf-oxide; ureas such as N,N' - dimethyl imida zol inone. Preferred are acetone, tetrahydrofuran, ethyl acetate, butyl acetate, acetonitrile, N,N-dimethylforrnamide, and dimeth-ylsulfoxide. Particularly preferred are ethyl acetate, butyl acetate and acetonitrile. Most preferred are butyl acetate and acetonitrile. The solvents can be employed singly or in combination. The solvent can be employed in an amount of, preferably 0.01 to 100 liters, more preferably 0.5 to 5 liters, per one mole of the hydroxypyrimidine compound. The amount may vary depending on homogeneity and dispers-ability of the reaction mixture. The reaction can be performed by reacting the hydroxypyrimidine compound and the organic sulfonyl ha-lide or sulfonic anhydride in a solvent in the presence of a base with stirring under inert gas atmosphere. The base can be added portionwise. The reaction can be carried out at a temperature of, preferably -30 to 250°C, more preferably 0 to 150°C. There are no specific limitations with respect to the surrounding pressure. The resulting product of the reaction, that is, the 2- (N-methyl-N-methanecarbonsulf onylamino) pyrimidine compound of the formula (3) , can be isolated and purified according to the conventional procedures such as distillation, crystallization, recrystallization, and column chroma tography. The 2- (N-methyl-N-methanesulfonylamino) pyrimidine compound of the formula (3) and other pyrimidine com- pounds of the formula (8) can be prepared from a hydroxy-pyrimidine compound of the formula (1) via a 2-substituted pyrimidine compound of the formula (6) in the following steps (V) and (VI) : (Formula Removed) In the formula (8), R has the same meaning as described above, and each of R1 and R2 independently is a hydrogen atom, an alkyl group, an alkylsulfonyl group, or aryl-sulfonyl group. Step (V) In the step (V) , a hydroxypyrimidine compound of the formula (1) is reacted with a halogenating agent such as a chlorinating agent, an organic sulfonyl halide of the formula (2) : R' S02X (2) in which R1 has the same meaning as above and X is a halogen atom, or an organic sulfonic anhydride of the formula (2a) : (R'S02)20 (2a) in which R1 has the same meaning as above. Examples of the halogenating agents include phosphorus oxychloride and thionyl chloride. The halogenating agents can be employed singly or in combination. The halogenating agent can be employed in an amount of, preferably 0.1 to 50 mol., more preferably 1 to 20 mol. , most preferably 1.5 to 10 mol., per one mol. of the hydroxypyrirnidine compound. Examples of the organic sulfonyl halides and sulfon-ic anhydrides are those described hereinbefore. The organic sulfonyl halide or sulfonic anhydride can be employed in an amount of, preferably 0.1 to 20 mol., more preferably 0.5 to 5 mol., most preferably 1 to 2 mol., per one mol. of the hydroxypyrimidine compound. The reaction can be performed in the presence or absence of a solvent. There are no specific limitations with respect to the solvent, so far as the solvent does not disturb the reaction. Examples of the solvents include aromatic hydrocarbons such as toluene; halogenated aromatic hydrocarbons such as chlorobenzene; nitrated hydrocarbons such as nitrobenzene; halogenated aliphatic hydrocarbons such as methylene chloride and 1,2-dichloro-ethane; amides such as N,N-dimethylfonnamide/ water (not for a halogenating agent) ; nitriles such as acetonitrile and propionitrile; carboxylic acid esters such as ethyl acetate, propyl acetate, butyl acetate; ketones such as acetone, methyl ethyl ketone, diethyl ketone,- and ethers such as diethyl ether and tetrahydrofuran. Preferred are butyl acetate, toluene, methylene chloride, acetonitrile, chlorobenzene, nitrobenzene, and N,N-dimethylformamide. The solvents can be employed singly or in combination. The solvent can be employed in the reaction utilizing the halogenating agent in an amount of, preferably 0.01 to 10 liters, more preferably 0.1 to 2 liters, per one mole of the hydroxypyrimidine compound. The amount. may vary depending on homogeneity and dispersability of (Formula Removed) the reaction mixture. The solvent can be employed in the reaction utilizing the sulfonyl chloride or sulfonic anhydride in an amount of, preferably 0.1 to 50 liters, more preferably 0.5 to 2 liters, per one mole of the hydroxypyrimidine compound. The amount may vary depending on homogeneity and dispersability of the reaction mixture. The reaction can be carried out by reacting the hydroxypyrimidine compound and the halogenating agent, in a solvent with stirring under inert gas atmosphere. The reaction can be carried out at a temperature of, preferably 0 to 200°C, more preferably 50 to 120°C. There are no specific limitations with respect to the surrounding pressure . The reaction can be carried out by reacting the hydroxypyrimidine compound and the sulfonyl halide or sulfonyl anhydride in a solvent with stirring under inert gas atmosphere. The. reaction can be carried out at a temperature of, preferably -30 to 200°C, more preferably 0 to 50°C. There are no specific limitations with respect to the surrounding pressure. The resulting product of the reaction, that is, a 2-substituted pyrimidine compound such as a chloropyrimid-ine compound or a sulfonyloxypyrimidine compound, can be isolated and purified according to the conventional procedures such as distillation, crystallization, recrystal-lization, and column chromatography. Step (VI) In the step (VI) , the 2 -substituted pyrimidine compound, such as a chloropyrimidine compound or a sulfonyloxypyrimidine compound prepared in the step (V) is reacted with an amine compound having the formula (7) : (Formula Removed) wherein each of R1 and R2 is the same as above. Examples of the groups of R1 and R2 include a hydrogen atom, alkyl groups such as methyl, ethyl, propyl, butyl, pentyl and hexyl; alkylsulfonyl groups such as methanesulfonyl; and arylsulfonyl groups such as benzene-sulfonyl and p-toluenesulfonyl. The amine compound can be employed in an amount of, preferably 0.1 to 30 mol., more preferably 1 to 5 mol. , per one mol. of the 2-substituted pyrimidine compound. The reaction is preferably performed in the presence of a base. Examples of the bases are those described hereinbefore. The base can be preferably employed in an amount of, preferably 0.1 to 30 mol., more preferably 1 to 5 mol., per one mol. of the 2-substituted pyrimidine compound. The reaction can be performed in the presence or absence of a solvent. There are no specific limitations with respect to the solvent, so far as the solvent does not disturb the reaction. Examples of the solvents include water; ketones such as acetone, methyl ethyl ke-tone, and diethyl ketone/ ethers such as diethyl ether and tetrahydrofuran; esters such as ethyl acetate, propyl acetate, and butyl acetate; nitriles such as acetonitrile and propionitrile; amides such as NjN-dimethylformamide and N-methylpyrrolidone; sulfoxides such as dimethylsulf-oxide; ureas such as N,N' -dimethylimidazolidinone. Preferred are acetone, tetrahydrofuran, ethyl acetate, butyl acetate, acetonitrile, N,N-dimethylformand.de, and dimeth-ylsulfoxide. Particularly preferred are ethyl acetate, butyl acetate and acetonitrile. The solvents can be employed singly or in combination. The solvent can be employed in an amount of, preferably 0.01 to 100 liters, more preferably 0.5 to 5 liters, per one mole of the 2-substituted pyrimidine compound. The amount may vary depending on homogeneity and dispers-ability of the reaction mixture. The reaction can be conducted by reacting the 2-substituted pyrimidine compound and the amine compound in a solvent in the presence of a base with stirring under inert gas atmosphere. The reaction can be carried out at a temperature of, preferably -20 to 250°C, more preferably 25 to 150°C. There are no specific limitations with respect to the surrounding pressure. The reaction can be conducted in two separate liquid phases in the presence of a phase transfer catalyst. Examples of the phase transfer catalysts include tetra-methylammonium chloride, tetramethylammonium bromide, tetraethylammonium fluoride, tetraethylammonium chloride, tetraethylammonium bromide, tetrapropylammonium bromide, tetrapropylammonium iodide, tetrabutylammonium fluoride, tetrabutylammonium chloride, tetrabutylammonium bromide, tetrabutylammonium iodide, tetrapentylammonium bromide, tetrahexylammonium bromide, tetraheptylammonium bromide, tetraoctylammonium bromide, benzyldimethyltetradecyl-ammonium chloride, benzyltriethylammonium chloride, phenyltrimethylammonium chloride, phenyltrimethylamrnonium iodide, and hexadecyltrimethylammonium chloride. Preferred are tetrabutylammonium chloride, tetrabutylammonium bromide, tetrabutylammonium iodided, benzyltriethylammonium chloride, and hexadecyltrimethylammonium chloride. Most preferred are tetrabutylammonium bromide, benzyltriethylanmonium chloride, and hexadecyltrimethylammonium chloride. The phase transfer catalyst can be employed in an amount of 0.01 to 0.5 mol., preferably 0.05 to 0.2 mol., per .one mol. of the 2-substituted pyrimidine compound. The resulting product of the reaction, that is, a 2-(N-methyl-N-methanesulfonylamino) pyrimidine compound of the formula (3) or other aminopyrimidine compounds of formula (8) , can be isolated and purified according to the conventional procedures such as distillation, crystallization, recrystallization, or column chromatography. The present invention is further described by the following non-limiting examples. [Example 1] Preparation of 4- (4-fluorophenyl) -6-isopro-pyl-5-methoxycarbonyl-3, 4-2 (1H) -dihydropyrimidinone In a 500 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 28.8 g (0.2 mol.) of methyl isobutyrylacetate, 24.8 g (0.2 mol.) of 4-fluorobenzaldehyde, 21.0 g (0.35 mol.) of urea, 200 mg (2 mmol.) of copper(I) chloride, 2 mL of sulfuric acid, and 200 mL of methanol. The content of the flask was heated to 64-65°C for 24 hours under reflux with stirring, to carry out the reaction. There was precipitated crystalline product. The crystalline product was collected on a filter paper and washed with methanol to obtain 49.7 g of 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3,4-2 (1H)-dihydropyrimidinone as a colorless crystalline product having the below-mentioned characteristics. The yield was 85% (based on the amount of methyl isobutyrylacetate). ra.p.: 223-225°C UV ^ (CH3CN, nm) : 194.3, 278.6 IR (KBr, cm-1): 3296, 3229, 3137, 2963, 1685, 1629, 1504, 1225, 1097. XH-NMR (DMSO-dg, 6 (ppm) ) : 1.14 (6H, dd, J=6.8, 6.9Hz), 3.52 (3H, s), 4.0-4.2 (1H, m) , 5.15 (1H, d, J=3.4Hz), 7.1-7.2 (2H, m) , 7.2-7.3 (2H, m), 7.76 (1H, d, J=3.2Hz), 8.91 (1H, s). HRMS: 292.1247 (theoretical value (C15H17FN2O3 (M+)) 292.1223) [Example 2] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl - 5 - me thoxycarbonyl -3,4-2(lH)- dihydropyrimidinone The procedures of Example 1 were repeated except for replacing 200 mg (2 mmol.) of copper(I) chloride with 5.41 g (20 mmol.) of iron (III) chloride • hexahydrate. There was obtained 35.6 g of 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3 , 4 -2 (IH) -dihydropyrimidinone. The yield was 61% (based on the amount of methyl isobutyryl-acetate). [Example 3] Preparation of 4-(4-fluorophenyl)-2-hydroxy-6 - i sopropyl - 5 -me thoxycarbonylpyrimidine In a 50 mL-volume glass flask equipped with a stir-rer and a thermometer was placed 11 mL (144 mmol.) of nitric acid (60-61%, sp.gr.: 1.38). To the nitric acid was slowly added at room temperature 4.00 g (13.7 mmol.) of 4 - (4 - f luorophenyl) - 6 - isopropyl - 5 -methoxycarbonyl -3,4-2 (IH) -dihydropyrimidinone prepared in the same manner as in Example 1, and the mixture was subjected to reaction for 30 minutes at room temperature. After the reaction was complete, the reaction mixture was neutralized by placing the mixture in 140 mL of saturated aqueous sodium hydrogen carbonate solution. The reaction mixture was then extracted with ethyl acetate. The organic liquid portion was separated and concentrated under reduced pressure. The residue was crystallized from toluene. The crystalline product was collected on a filter and washed with toluene to obtain 3.64 g of 4-(4-f luorophenyl) -2 -hydroxy- 6 - isopropyl - 5 -methoxycarbonyl -pyrimidine as a colorless crystalline product having the below-mentioned characteristics. The yield was 92% (based on the amount of 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3,4-2(IH)-dihydropyrimidinone). m.p.: 193°C (decomposed) UV A^ (O^CN, nm) : 196.6, 243.2, 317.9 IR (KBr, cm"1) : 2991, 2887, 1717, 1653, 1589, 1433, 1280, 1223. AH-NMR (DMSO-dg, 6 (ppm) ) : 1.23 (6H, d, J=6.8Hz), 3.0-3.2 (IH, m), 3.56 (3H, s), 7.3-7.4 (2H, m) , 7.5-7.6 (2H, m), 12.25 (IH, brs) . HRMS: 290.1054 (theoretical value (C15H15FN2O3 (M+) ) 290.1067) [Example 4] Preparation of 4-(4-fluorophenyl)-2-hydroxy-6 - isopropyl - 5 -methoxycarbonylpyrimidine In a 50 mil-volume glass flask equipped with a stir-rer and a thermometer were placed 2.92 g (10 mmol.) of 4-(4-f luorophenyl) -6-isopropyl-5-methoxycarbonyl-3, 4-2 (IH)-dihydropyrimidinone prepared in the same manner as in Example 1 and 5 mL of acetic acid. To the mixture was slowly added 3.74 mL (50 mmol.) of nitric acid (60-61%, sp.gr.: 1.38) . To the mixture was further added 0.07 g (1 mmol.) of sodium nitrite, and the reaction was carried out for one hour at room temperature. After the reaction was complete, the reaction mixture was neutralized by placing the mixture in 50 mL of saturated aqueous sodium hydrogen carbonate solution. The reaction mixture was then extracted with ethyl acetate. The organic liquid portion was separated and concentrated under reduced pressure. The residue was crystallized from toluene. The crystalline product was collected on a filter and washed with toluene to obtain 2.61 g of 4-(4-f luorophenyl) - 2 - hydroxy- 6 - i sopropyl - 5 - me thoxycarbony 1 -pyrimidine as a colorless crystalline product. The yield was 90% (based on the amount of 4- (4-fluorophenyl) -6-iso-propyl-5-methoxycarbonyl-3, 4-2 (IH) -dihydropyrimidinone) . [Example 5] Preparation of 4-(4-fluorophenyl)-2-hydroxy-6-isopropyl-5-methoxycarbonylpyrimidine In a 200 mL-volume glass flask equipped with a stir-rer and a thermometer was placed 54.0 g (735 mmol.) of nitric acid (60-61%, sp.gr.: 1.38). To the nitric acid was slowly added at room temperature 30.6 g (105 mmol.) of 4 - (4 - f luorophenyl) - 6 - isopropyl - 5 -methoxycarbonyl -3,4- 2 (1H)-dihydropyrimidinone prepared in the same manner as in Example 1, and the mixture was subjected to reaction for 30 minutes at room temperature. After the reaction was complete, the reaction mixture was poured into 162 mL of water. The aqueous mixture was neutralized by adding 61 g of aqueous sodium hydroxide solution (48 wt.%) to precipitate a crystalline product. .The crystalline product was collected by filtration and dried to obtain 27.6 g of 4- (4-fluorophenyl) -2-hydroxy-6-isopropyl-5-methoxy-carbonylpyrimidine as a colorless crystalline product. The yield was 91% (based on the amount of 4- (4-fluorophenyl ) -6-isopropyl-5 -methoxycarbonyl-3, 4 -2 (1H) -dihydropyrimidinone ) . [Example 6] Preparation of 4- (4- f luorophenyl) -2 -hydroxy- 6 - isopropyl - 5 -methoxycarbonylpyrimidine In a 2 L-volume glass flask equipped with a stirrer • and a thermometer was placed 323.3 g (3.09 mol.) of nitric acid (60-61%, sp.gr.: 1.38). The concentrated nitric acid was then cooled to 10°C. To the nitric acid was added 2.36 g (34.2 mmol.) of sodium nitrite, and was further added slowly 100 g (342 mmol.) of 4-(4-fluorophenyl) -6-isopropyl-5-methoxycarbonyl-3,4-2 (1H) -dihydropyrimidinone prepared in the same manner as in Example 1. The mixture was subjected to reaction for 2 hours at a temperature of 10-12°C. After the reaction was complete, 970 mL of water was poured into the reaction mixture. The aqueous mixture was then neutralized by adding 257 g of aqueous sodium hydroxide solution (48 wt.%) to precipitate a crystalline product. The crystalline product was collected by filtration and dried to obtain 93.3 g of 4- (4-fluorophenyl) -2-hydroxy-6-isopropyl -5-methoxycarbonylpyrimidine as a colorless crystalline product. The yield was 94% (based on the amount of 4-(4-fluorophenyl) -6-isopropyl-5-methoxycarbonyl-3,4-2 (1H) - dihydropyrimidinone). [Example 7] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl -5 -methoxycarbonyl -2 - (N-methyl -N-methanesulf onyl -amino)pyrimidine In a 200 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 5.81 g (20 mmol.) of 4- (4-fluorophenyl) -2-hydroxy-6-iso-propyl-5-methoxycarbonylpyrimidine, 3.59 g (26 mmol.) of potassium carbonate (available from Asahi Glass Works, Co., Ltd., Lot No. 1111632, particle size distribution: 75-250 fim: 14%, 75 /jm pass: 86%) , and 40 mL of butyl acetate. To the mixture was slowly added 4.19 g (22 mmol.) of p-toluenesulfonyl chloride under stirring, and the reaction was carried out at 40°C for 4 hours. Subsequently, the reaction mixture was cooled to room temperature. To the cooled reaction mixture were added 2 .84 g (26 mmol.) of N-methylmethanesulfonamide and 4.15 g (30 mmol.) of potassium carbonate (same as above) . The mixture was heated to 110-125°C for 2 hours under re fluxing to carry out a reaction. After the reaction was complete, the mixture was cooled to room temperature. To the cooled mixture were added 25 mL of water and 20 mL of acetone, and the organic liquid portion was separated. The organic liquid portion was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The dry organic liquid portion was filtered and concentrated under reduced pressure. The residue was crystallized from heptane, to obtain 6.58 g of 4 - (4 - f luorophenyl) - 6 - isopropyl - 5 -methoxycarbonyl -2-(N-methyl-N-methanesulfonylamino) pyrimidine as a pale yellow crystalline product. The yield was 86% (based on the amount of 4- (4-fluorophenyl)-2-hydroxy-6-isopropyl-5-me thoxycarbonylpyrimidine) [Example 8] Preparation of 4-(4-fluorophenyl)-6-isopro- pyl-5 -methoxycarbonyl-2 - (N-methyl-N-methanesulfonyl -amino)pyrimidine In a 1000 mL-volume glass flask equipped with a starrer, a thermometer and a reflux condenser were placed 50.0 g (172 mmol.) of 4- (4-fluorophenyl) -2~hydroxy-6-iso-propyl-5-methoxycarbonylpyrimidine, 20.8 g (189 mmol. ) of sodium t-pentoxide, and 344 mL of acetonitrile, and the resulting mixture was stirred at 0-10°C for 30 minutes. To the mixture was slowly added 36.1 g (189 mmol.) of p-toluenesulfonyl chloride, and the reaction was carried out at for 5 hours at room temperature. Subsequently, the reaction mixture was cooled to a temperature of 0-10°C. To the cooled reaction mixture were added 28.2 g (258 mmol.) of N-methylmethanesulfonamide and 26.5 g (241 mmol.) of• sodium t-pentoxide. The mixture was kept at 0-10°C for one hour and then heated to 75-82°C for 2 hours under refluxing, to carry out a reaction. After the reaction was complete, the mixture was cooled to room temperature. To. the cooled mixture was added 344 mL of water. The aqueous mixture was cooled to 0-10°C and stirred for one hour, precipitating a crystalline product . The crystalline product was collected by filtration and dried, to obtain 45.3 g of 4-(4-fluorophenyl)-6-iso-propyl-5-methoxycarbonyl-2- (N-methyl-N-methanesulf on-ylamino)pyrimidine as a pale yellow crystalline product. The yield was 68% (based on the amount of 4-(4-fluorophenyl ) -2 -hydroxy- 6 - isopropyl - 5 -methoxycarbonyl -pyrimidine). [Example 9] Preparation of 4-(4-fluorophenyl)-6-isopropyl - 5 -methoxycarbonyl -2 - (N-methyl -N-methanesulf onyl -amino) pyrimidine from methyl isobutyrylacetate, 4-f luorobenzaldehyde and urea 1) In a 200 L-volume glass-lined reaction vessel equipped with a stirrer, a thermometer and a reflux condenser were placed 24.4 kg (169 mol.) of methyl iso- butyrylacetate, 20.0 kg (161 mol.) of 4-fluorobenzalde-hyde, 16.9 kg (282 mol.) of urea, 0.2 kg (2 mol.) of copper(I) chloride, 3.0 kg of sulfuric acid, and 80.4 kg of methanol. The mixture was heated to 64-66°C for 20 hours under refluxing, to carry out reaction. After the reaction was complete, the reaction mixture was cooled to room temperature, to precipitate a crystalline product. The crystalline product was collected on a filter paper and washed with methanol to obtain 43.4 kg of 4-(4-f luorophenyl) -6-isopropyl'-5-methoxycarbonyl-3,4-2 (IH) -dihydropyrimidinone as a colorless crystalline product. 2) In a 200 L-volume glass-lined reaction vessel equipped with a stirrer and a thermometer were placed 62.5 kg (615.6 mol.) of diluted nitric acid and 0.5 kg (6.8 mol.) of sodium nitrite. To the mixture was slowly added under chilling 20.0 kg (68.4 mmol.) of the 4-(4-f luorophenyl) -6-isopropyl-5-methoxycarbonyl-3,4-2 (IH) -dihydropyrimidinone prepared as above. The resulting mixture was subjected to reaction at a low temperature (10°C) . After the reaction was complete, the reaction mixture was neutralized by addition of an aqueous methanol solution of sodium hydroxide. Subsequently, an aqueous sodium hydroxide solution was added to the mixture. The resulting mixture was placed under reduced pressure to distill methanol off. To the residue were added 96.5 kg of acetone and 96.5 kg of water. The aqueous residue was then neutralized by addition of acetic acid to precipitate a crystalline product. The crystalline product was collected on a filter paper and washed with a acetone/water mixture, to give 17.9 kg of 4- (4- f luorophenyl) -2-hydroxy-6-isopropyl-5-methoxycarbonylpyrimidine. 3) In a 200 L-volume glass-lined reaction vessel equipped with a stirrer, a thermometer and a reflux condenser were placed 17.9 kg (62.0 mol.) of.4-(4-fluorophenyl ) - 2 - hydroxy- 6 - i sopropyl - 5 -methoxycarbonylpyrimidine prepared as above, 107.7 kg of butyl acetate, 11.1 kg (80.3 mol.) of potassium carbonate (available from Asahi Glass Works, Co., Ltd., Lot No. 1111632, particle size distribution: 75-250 fan: 14%, 75 /xmpass: 86%), and 12.9 kg (67.7 mol.) of p-toluenesulfonyl chloride. The mixture was heated at 60°C for 2 hours, to carry out reaction. Subsequently, the reaction mixture was cooled to room temperature. To the cooled mixture were added 8 . 8 kg (80.6 mol.) of N-methylmethanesulfonamide and 12.9 kg (93.3 mol.) of potassium carbonate, and the resulting mixture was heated at 122-125°C for 3 hours, for carrying reaction. After the reaction was complete, the reaction mixture was cooled to room temperature. To the cooled mixture were added acetone and water, and the organic liquid portion was separated. The organic liquid portion was then washed successively with aqueous sodium hydroxide solution (3 wt.%) and a saturated aqueous sodium chloride solution. The washed organic liquid portion was concentrated under reduced pressure. Isopropyl alcohol and water were added to the residue, resulting in precipitation of a crystalline product. The crystalline product was filtered on a filter paper and washed with isopropyl alcohol. The washed crystalline product and 85.7 kg of acetone were placed in a 200 L-volume glass lined reaction vessel equipped with a stirrer, a thermom--eter and a reflux condenser. The mixture was stirred at 50-55°C, to dissolve the crystalline product in acetone. The insoluble was removed with a line filter. Subsequently, 58.3 kg of water was added to the solution, to precipitate a crystalline product. The crystalline product was collected on a filter paper and washed with an acetone/water mixture, to give 19.5 kg of 4-(4-fluorophenyl) -6-isopropyl-5-methoxycarbonyl-2- (N-methyl-N-methane sul fonylamino) pyrimidine. [Example 10] Preparation of 2 -chloro-4 - (4- f luorophenyl )-6 - isopropyl - 5 -methoxycarbonylpyrimidine In a 25 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 1.00 g (3.43 mmol.) of 4-(4-fluorophenyl)-2-hydroxy-6-isopropyl-5-methoxycarbonylpyrimidine and 3.4 mL (3.7 mmol.) of phosphorus oxychloride. The mixture was heated to 100-106°C for 1.5 hours under refluxing, to carry out reaction. After the reaction was complete, the reaction mixture was cooled to room temperature, and poured into an ice/water mixture. The resulting aqueous mixture was neutralized with a saturated aqueous sodium hydrogen carbonate solution. The neutralized aqueous mixture was extracted with ethyl acetate. The ethyl acetate portion was separated, washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The dried ethyl .acetate portion was filtered and concentrated under reduced pressure, to obtain 1.03 g of 2-chloro-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonylpyrimidine as a colorless crystalline product having the below-mentioned characteristics. The yield was 97% (based on the amount of 4-(4-fluorophenyl)-2-hydroxy- 6 - isopropyl -5 -methoxycarbonylpyrimidine) . m.p. : 99-101°C UV * (CH3GN, nm) : 194.7, 276.5 JR (KBr, cm'1): 2980, 1728, 1542, 1508, 1227, 1086. XH-MMR (DMSO-de, δ (ppm) ) : 1.33 (6H, d, J=6.8Hz), 3.1-3.2 (1H, m) , 3.76 (3H, s) , 7.15 (2H, t, J=8.5Hz), 7.6-7.7 (2H, m) . HRMS: 308.0695 (theoretical value (C15H14C1FN2O2 (M+) ) 308.0728) [Example 11] Preparation of 2-chloro-4-(4-fluorophenyl)-6 - isopropyl - 5 -methoxycarbonylpyrimidine In a 25 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 1.00 g (3.43 mmol.) of 4-(4-fluorophenyl)-2-hydroxy-6- isopropyl-5-methoxycarbonylpyrimidine, 0.5 mL (3.9 mmol.) of thionyl chloride, 3.44 mL of toluene, and 0.11 mL of N,N-dimethylformamide. The mixture was heated to 80°C for 3 hours, to carry out reaction. After the reaction was complete, the reaction mixture was cooled to room temperature, and poured into an ice/water mixture. The resulting aqueous mixture was neutralized with a saturated aqueous sodium hydrogen carbonate solution. The neutralized aqueous mixture was extracted with ethyl acetate. The ethyl acetate portion was separated, washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The dried ethyl acetate portion was filtered and concentrated under reduced pressure, to obtain 0.80 g of 2-chloro-4-(4-fluoro-phenyl) -6-isopropyl-5-methoxycarbonylpyrimidine as a colorless crystalline product. The yield was 76% (based on the amount of 4- (4-fluorophenyl) -2-hydroxy-6-isopro-pyl-5-methoxycarbonylpyrimidine) . [Example 12] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl - 5 -methoxycarbonyl - 2 - (N-methyl -N-methanesulf onyl -amino) pyrimidine In a 25 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 546 mg (5 mmol.) of N-methylmethanesulfonamide, 551 mg (5 mmol.) of sodium t-pentoxide, 10 mL of acetonitrile, and 309 mg (1 mmol.) of 2-chloro-4-(4-fluorophenyl)-6-isopro-pyl-5-methoxycarbonylpyrimidine. The mixture was heated to 81-82°C for 3 hours under refluxing, to carry out reaction. After the reaction was complete, the reaction mixture was cooled to room temperature. To the cooled mixture was added 10 mL of water, and the aqueous mixture was extracted with ethyl acetate. The ethyl acetate portion was separated, and dried over anhydrous magnesium sulfate. The dried ethyl acetate portion was filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (column: Wako Gel C-200, eluent: hexane/ethyl acetate (2:1, volume ratio) ) . There was obtained 339 mg of 4- (4-fluoro-phenyl) -6-isopropyl-5-methoxycarbonyl-2- (N-methyl-N-methanesulfonylamino)pyrimidine. The yield was 89% (based on the amount of 2-chloro-4-(4-fluorophenyl)-6-i sopropyl - 5 - methoxycarbonylpyrimidine) . [Example 13] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl-5 -methoxycarbonyl -2 -methanesulf onyloxypyrimidine In a 100 mL-volume glass flask were placed 10.0 g (34.4 mmol.) of 4- (4- f luorophenyl) -2- hydroxy-6-i sopropyl-5-methoxycarbonylpyrimidine, 5.22 g (58.5 mmol.) of tri-ethylamine, and 34 mL of acetonitrile. The mixture in the flask was chilled to 0-5°C in an ice bath. To the chilled mixture was slowly added 5.12 g (44.7 mmol.) of methanesulfonyl chloride, and the resulting mixture was subjected to reaction at 20-25°C for 2 hours. After the reaction was complete, to the reaction mixture was added 60 mL of water. The aqueous reaction mixture was extracted with toluene and the toluene portion was separated. The toluene portion was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The dried mixture was filtered and concentrated under reduced pressure. The residue was crystallized from methanol, to give 11.3 g of 4-(4-f luorophenyl) - 6 - i sopropyl - 5 -methoxycarbonyl - 2 -methane -sulf onyloxypyrimidine as a colorless crystalline product having the below-mentioned characteristics. The yield was 89% (based on the amount of 4- (4-f luorophenyl) -2-hydroxy- 6 - isopropyl - 5 -methoxycarbonylpyrimidine) . m.p.: 110-111°C UV *max (CH3CN, run): 193.7, 276.8 IR (KBr, cm'1): 2980, 1724, 1562, 1391, 1250, 1175, 1079, 971. (CDC13/ δ (ppm) ) : 1.33 (6H, d, J=6.6Hz), 3.20 (1H, m), 3.60 (3H, s) , 7.1-7.2 (2H, s) , 7.6-7.8 (2H, m) . HRMS: 368.0842 {theoretical value (C15H17FN2OSS (M+)) 368.0892) [Example 14] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl - 5 -methoxycarbonyl - 2 - (p - toluenesulf onyloxy) pyrimidine In a 200 mL-volume glass flask were placed 27.6 g (95.1 mmol.) of 4 - (4 - fluorophenyl) - 2 -hydroxy- 6 - i sopropyl -5-methoxycarbonylpyrimidine, 12.5 g (123 mmol.) of tri-ethylamine, and 95 mL of acetonitrile. The mixture of the flask was chilled to 0-5°C in an ice bath. To the chilled mixture was slowly added 20.0 g (105 mmol.) of p-toluenesulfonyl chloride, and the resulting mixture was subjected to reaction at 20-25°C for one hour. After the reaction was complete, to the reaction mixture was added 95 mL of water. The aqueous reaction mixture was extracted with toluene and the toluene portion was separated. The toluene portion was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The dried mixture was filtered and concentrated under reduced pressure. The residue was crystallized from methanol, to give 35.9 g of 4-(4-fluorophenyl) -6-isopropyl-5-methoxycarbonyl-2- (p-toluenesulf onyloxy) pyrimidine as a colorless crystalline product having the below-mentioned characteristics. > The yield was 85% (based on the amount of 4- (4-fluorophenyl) -2-hydroxy- 6 - isopropyl - 5 -methoxycarbonylpyrimidine) . m.p.: 94-96°C UV Xm (CH3CN, run): 194.9, 275.2 IR (KBr, CUT1) : 2961, 1734, 1539, 1389, 1352, 1247, 1090, 980. (CDC13, δ (ppm) ) : 1.23 (6H, d, J=6.8Hz), 2.45 (3H, s), 3.0-3.2 (1H, m) , 3.74 J=8.5Hz). HRMS: 444.1155 (theoretical value (C32H21FN2O5S (M+) ) 444.1194) [Example 15] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl - 5 -methoxycarbonyl -2 - benzene sulf onyloxypyrimidine The procedures of Example 13 were repeated except for replacing p-toluenesulfonyl chloride with 18.5 g (105 mmol.) of benzenesulfonyl chloride. There was obtained 39.3 g of 4-(4-fluorophenyl)-6-isopropyl - 5 -methoxycarbonyl -2 -benzenesulf onyloxypyrimidine as a pale yellow crystalline product having the below-mentioned characteristics. The yield was 96% (based on the amount of 4- (4-fluorophenyl) -2-hydroxy-6-isopropyl - 5 -methoxycarbonylpyrimidine) . XH-MMR (CDC13, δ (ppm) ) : 1.21 (6H, d, J=6.4Hz), 3.0-3.1 (1H, m), 3.73 (3H, s), 7.1-7.2 (2H, m) , 7.5-7.7 (5H, m) , 8.1-8.2 (2H, m) . [Example 16] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl-5-methoxycarbonyl-2- (2,4, 6-trimethylbenzenesulfonyl-oxy) pyrimidine The procedures of Example 13 were repeated except for replacing p-toluenesulfonyl chloride with 23.0 g (105 mmol.) of 2,4,6-trimethylbenzenesulfonyl chloride. There was obtained 37.7 g of 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-2- (2,4, 6-trimethylbenzene-sulfonyloxy) pyrimidine as a pale yellow crystalline product having the below-mentioned characteristics. The yield-was 84% (based on the amount of 4- (4-f luorophenyl)-2-hydroxy-6 -isopropyl-5-methoxycarbonylpyrimidine).. (CDCLj, δ (ppm) ) : 1.17 (6H, d, J=6. 8Hz) , 2.34 (3H, s) , 2.67 (6H, s), 3.0-3.1 (1H, m), 3.73 (3H, s), 7.00 (2H, s), 7.0-7.2 (2H, m), 7.4-7.5 (2H, m). [Example 17] Preparation of 4- (4-fluorophenyl) -6-isopropyl -5-methoxycarbonyl-2- (2,4, 6-triisopropylbenzenesul-f onyloxy) pyrimidine The procedures of Example 13 were repeated except for replacing p-toluenesulfonyl chloride with 31.8 g (105 mmol.) of 2,4, 6-triisopropylbenzenesulf onyl chloride. There was obtained 47.1 g of 4-(4-fluorophenyl)-6- 1 sopropyl - 5 - me t hoxycarbonyl -2- (2,4,6-trii sopropylbenz ene - sulfonyloxy) pyrimidine as a pale yellow crystalline prod uct having the be low-mentioned characteristics. The yield was 89% (based on the amount of 4- (4-fluorophenyl)- 2 -hydroxy- 6 - isopropyl - 5 -methoxycarbonylpyr imidine) . 1H-NMR (CDC13, δ(ppm)): 1.12 (6H, d, J=6.6Hz), 1.19 (12H, d, J=6.8Hz), 1.27 (6H, d, J=7.1Hz), 2.8-2.95 (1H, m) , 2.95-3.1 (1H, m) , 3.73 (3H, s), 4.1-4.3 (2H, m), 7.0-7.1 (2H, m) , 7.20 (2H, s) , 7.4-7.5 (2H, m) . [Example 18] Preparation of 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-2- (p-methoxybenzenesulfonyloxy) -pyrimidine The procedures of Example 13 were repeated except for replacing p-toluenesulfonyl chloride with 21.7 g (105 mmol.) of p-methoxybenzenesulfonyl chloride. There was obtained 39.9 g of 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-2 - (p-methoxybenzenesulfonyl-oxy) pyrimidine as a colorless crystalline product having the below-mentioned characteristics. The yield was 91% (based on the amount of 4- (4-fluorophenyl) -2-hydroxy-6-i sopropyl - 5 -methoxycarbonylpyrimidine) . 3H-NMR (CDC13, δ (pptn) ) : 1.25 (6H, d, J=6.8Hz), 3.0-3.2 (1H, m) , 3.. 74 (3H, s) , 3.88 (3H, s), 6.99 (2H, dd, J=2.0, 9.0Hz), 7.0-7.2 (2H, m) , 7.5-7.7 (2H, m) , 8.07 (2H, dd, J=2.2, 9.0Hz). [Example 19] Preparation of 4- (4-fluorophenyl) -6-isopro-pyl-5-methoxycarbonyl-2- (p-chlorobenzenesulfonyloxy) -pyrimidine The procedures of Example 13 were repeated except for replacing p-toluenesulfonyl chloride with 22.2 g (105 mmol.) of p-chlorobenzenesulfonyl chloride. There was obtained 39.9 g of 4-(4-fluorophenyl)-6-isopropyl - 5 -methoxycarbonyl - 2 - (p- chlorobenzenesulf onyl -oxy) pyrimidine as a colorless crystalline product having the below-mentioned characteristics. The yield was 89% (based on the amount of 4- (4-fluorophenyl)-2-hydroxy-6-isopropyl - 5 -methoxycarbonylpyrimidine) . 1H-NMR (GDC13, δ (ppm) ) : 1.23 (6H, d, J=6.6Hz), 3.0-3.2 (1H, m), 3.74 (3H, s), 7.1-7.2 (2H, m) , 7.5-7.7 (4H, m) , 8.0-8.1 (2H, m) . [Example 20] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl-5-methoxycarbonyl-2- (2-nitrobenzenesulfonyloxy) -pyrimidine The procedures of Example 13 were repeated except • for replacing p-toluenesulfonyl chloride with 23.3 g (105 mmol.) of 2-nitrobenzenesulfonyl chloride. There was obtained 28.0 g of 4-(4-fluorophenyl)-6-isopropyl - 5 -methoxycarbonyl - 2 - (2 -nitrobenzenesulf onyl -oxy) pyrimidine as an opaque crystalline product having the below-mentioned characteristics. The'yield was 62% (based on the amount of 4-(4-fluorophenyl)-2-hydroxy-6-i sopropyl - 5 -methoxycarbonylpyrimidine) Hl-NMR (CDC13, δ (ppm) ) : 1.17 (6H, d, J=6.8Hz), 3.0-3.2 (1H, m), 3.75 (3H, s) , 7.1-7.2 (2H, m) , 7.5-7.6 (2H, m) , 7.7-8.0 (3H, m) , 8.33 (1H, dd, J=1.7, S.lHz). [Example 21] Preparation of 4-(4-fluorophenyl)-6-isopro-pyl - 5 -methoxycarbonyl -2 - (N-methyl-N-methanesulf onyl-amino) pyrimidine In a 25 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 196 mg (1.8 mmol.) of N-methylmethanesulfonamide, 198 mg (1.8 mmol.) of sodium t-pentoxide, 7.5 mL of acetonitrlle, and 667 mg (1.5 mmol.) of 4- (4-fluorophenyl) -6-isopropyl-5-methoxycarbonyl-2- (p-toluenesulf onyloxy) pyrimidine. The mixture was heated to 81-82°C for 1.5 hours under , refluxing, to carry out reaction. After the reaction was complete, the reaction mixture was cooled to room temperature. To the cooled mixture was added 10 mL of water, and the aqueous mixture was extracted with ethyl acetate. The ethyl acetate portion was separated, and dried over anhydrous magnesium sulfate. The dried ethyl acetate portion was filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (column: Wako Gel C-200, eluent: hexane/ethyl acetate (2:1, volume ratio)). There was obtained 428 mg of 4-(4-fluorophenyl)-6-isopropy1-5-methoxycarbonyl-2- (N-methyl-N-methanesulfonylamino) -pyrimidine. The yield was 75% (based on the amount of 4-(4-fluorophenyl) -6-isopropyl-5-methoxycarbonyl-2- (p-toluenesulfonyloxy) pyrimidine) . [Example 22] Preparation of (2-amino-4-(4-fluorophenyl)-6 - i sopropyl - 5 -methoxycarbonylpyrimidine In a 25 mL-volume glass flask equipped with a stir-rer, a thermometer and a gas inlet were placed under ice-chilling 1.00 g (2.71 mmol.) of 4-(4-fluorophenyl)-6-iso- propyl - 5 -methoxycarbonyl -2 -methanesulf onyloxypyrimidine and 8.1 mL of tetrahydrofuran. The mixture was stirred at room temperature for 12 hours under gaseous ammonia atmosphere, for carrying out reaction. After the reaction was complete, 10 mL of water was added to the reaction mixture. The aqueuos mixture was then subjected to extraction with toluene. The toluene portion was separated, washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The dried toluene portion was filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (column: Wako Gel C-200, eluent: hexane/ethyl acetate (2:1, volume ratio)). There was obtained 0.63 g of 2-amino-4- (4-fluorophenyl) -6-iso-propyl-5-methoxycarbonylpyrimidine. The yield was 80% (based on the amount of 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl - 2 -methane sul fonyloxypyrimidine) . 6 - i sopropyl - 5 -methoxycarbonylpyr imidine [Example 23] Preparation of (4- (4-fluorophenyl) -6-iso-propyl - 5 -methoxycarbonyl - 2 -N-me thylaminopyrimidine In a 50 mL-volume glass flask equipped with a stir-rer, a thermometer and a dropping funnel was placed 6.00 g (16.3 mmol.) of 4-(4-fluorophenyl)-6-isopropyl-5-me thoxycarbonyl - 2 -methane sul f onyloxypyrimidine. Into the flask was slowly dropped under ice-chilling 5.06 g (65.2 mmol) of aqueous 40 wt.% methylamine solution. The resulting mixture was stirred for one hour at the same temperature for carrying out reaction. After the reaction was complete, 16 mL of water was added to the reaction mixture. The aqueuos mixture was then subjected to extraction with toluene. The toluene portion was separated, washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The dried toluene portion was filtered and concentrated under reduced pressure to give 4.81 g of 4-(4-fluorophenyl)-6- isopropyl-5 -methoxycarbonyl-2 -N-methylaminopyrimidine. The yield was 97% (based on the amount of 4- (4-f luoro-phenyl) -6-isopropyl-5-methoxycarbonyl-2-methanesulf onyl-oxypyrimidine) . [Example 24] Preparation of 4-(4-fluorophenyl)-6-isopropyl - 5 -methoxycarbonyl-2 - trif luoromethanesulf onyloxy-pyrimidine In a 300 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 8 .7 g (30.0 mmol.) of 4- (4-fluorophenyl) -2-hydroxy-6-isopropyl-5-me thoxycarbonylpyrimidine, 3.0 g (30.0 mmol.) of triethylamine, and 150 mL of toluene. The mixture in the flask was chilled to 0°C in an ice bath. To the chilled mixture was slowly added 8.46 g (30.0 mmol.) of tri-fluoromethanesulfonic anhydride, and the resulting mixture was subjected to reaction for 3 hours at the same temperature. After the reaction was complete, to the reaction mixture was added 90 mL of water. From the aqueous reaction mixture, an organic liquid portion was separated. The organic liquid portion was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (column: Wako Gel C-200, eluent: hexane/ ethyl acetate (8:2, volume ratio)). There was obtained 8.46 g of 4-(4-fluorophenyl)-6-isopro-pyl - 5 -methoxycarbonyl-2 - trifluoromethanesulfonyloxy-pyrimidine having the below-mentioned characteristics as a colorless oil. The yield was 74% (based on the amount of 4 - (4 - f luorophenyl) -2 -hydroxy- 6 - isopropyl - 5 -methoxycarbonylpyrimidine) . IR (KBr, cm"1): 3421, 2978, 1737, 1570, 1429, 1222, 1136, 973, 851 '•H-NMR (CDC13, 6(ppm)): 1.33 (6H, d, J=6.6Hz), 3.1- 3.2(1H, m), 3.80 (3H, s) , 7.1-7.2 (2H, m) , 7.7-7.8 (2H, m) HRMS: 422.0585 (theoretical value (C16H14F4N2O5S (M+) ). 422.0560) [Example 25] Preparation of 4-(4-flurophenyl)-6-isopro-pyl - 5 - me thoxycarbony 1 - 2' - t r i f luorome thane sul f onyloxy-pyrimidine In a 300 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 2.9 g (10.0 mmol.) of 4-(4-fluorophenyl)-2-hydroxy-6-isopro-pyl-5-me thoxycarbony Ipyrimidine, 1.7 g (16.8 mmol.) of triethylamine, and 50 mL of toluene. The mixture in the flask was chilled to 0°C in an ice bath. To the chilled mixture was slowly added 2.4 g (14.1 mmol.) of tri-f luorome thane sul fonyl chloride, and the resulting mixture was subjected to reaction for 3 hours at the same temperature. After the reaction was complete, to the reaction mixture was added 30 mL of water. From the aqueous reaction mixture, an organic liquid portion was separated. The organic liquid portion was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (column: Wako Gel C-200, eluent: hexane/ ethyl acetate (8:2, volume ratio)). There was obtained 2.8 g of 4-(4-f luorophenyl)-6-isopropyl-5-methoxy-carbonyl-2-trifluoromethanesulfonyloxypyrimidine having the below-mentioned characteristics as a colorless oil. The yield was 66% (based on the amount of 4- (4-fluorophenyl ) -2 -hydroxy- 6 - isopropyl-5 -methoxycarbonylpyrimi-dine). [Example 26] Preparation of 4-(4-f luorophenyl)-6-iso-propyl-5-methoxycarbonyl-2- (N-methyl-N-methanesulfonyl-amino) pyrimidine In a 50 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 3.0 q- (7 mmol.) of 4- (4-fluorophenyl) -6-isopropyl-5-methoxy-carbonyl-2-trifluoromethanesulfonyloxypyrimidine, 1.45 g (10.5 rnmol.) of potassium carbonate (available from Wako Junyaku Co. , Ltd. , special grade) , and 14 mL of butyl acetate. The mixture was heated to 122-125°C for 3 hours under refluxing, to carry out reaction. After the reaction was complete, the reaction mixture was cooled to room temperature. To the reaction mixture were added 10 mL of water and 7 mL of acetone, and the organic liquid portion was separated. The organic liquid portion was washed with a saturated aqueous sodium chloride solution and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (column: Wako Gel C-200, eluent: hexane/ ethyl acetate (5:1, volume ratio)) . There was obtained 2.1 g of 4- (4-fluoro-phenyl) -6-isopropyl-5-methoxycarbonyl-2- (N-methyl-N-methanesulfonylamino)pyrimidine as a white crystalline product. The yield was 78% (based on the amount of 4-(4-f luorophenyl) - 6 - isopropyl -5 -methoxycarbonyl -2 -trif luoro-methane sul fonyloxypyrimidine) . [Example 27] Preparation of 4-(4-fluorophenyl)-6-isopropyl -5-methoxycarbonyl-2- (N-methyl-N-methanesulfonyl -amino) pyr imidine In a 50 mL-volume glass flask equipped with a stir-rer, a thermometer and a reflux condenser were placed 1.1 g (2.5 tnmol.) of 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-2- (p-toluenesulfonyloxy) pyrimidine, 0 .55 g (5.0 mmol.) of N-methylmethanesulfonamide, 0.69 g (5.0 rnmol.) of potassium carbonate (available from Wako Junyaku Co., Ltd., special grade),. 0.32 g (1.0 mmol.) of tetrabutylammonium bromide, 20 mL of toluene and 5 mL of water. The mixture was heated to 85°C for 28 hours under refluxing, to carry out reaction. After the reaction was complete, the reaction mixture was cooled to room temperature . To the reaction mixture were added 10 mL of water and 7 mL of acetone, and the orqanic liquid Dortipn ,was... separated. The organic liquid portion was analyzed by high performance liquid chromatography. It was confirmed that 0.6 g of 4 - (4 - f luorophenyl) - 6 - isopropyl - 5 -methoxy-carbonyl-2- (N-methyl-N-methanesulfonylamino) pyrimidine was produced. The yield was 63% (based on the amount of 4- (4-fluorophenyl) -6-isopropyl-5-methoxycarbonyl-2- (p-toluenesulfonyloxy)pyrimidine) . [Industrial Utility] The pyrimidine compound, particularly, 2-(N-methyl -N-methanesulf onylamino) pyrimidine compound, prepared by the invention is of value as an intermediate compound for the production of a cholesterol reducing agent (HMG-CoA reductase agent) . The compound of formula (3) can be converted to an HMG CoA reductase inhibitor by the processes disclosed in European Patent Application Publication No. 0521471, Bioorg. Med. Chem., 5, 437 (1997) and International Patent Application No. WO 00/49014. The disclosures of these references are incorporated herein by reference to demonstrate how a compound of formula (3) or formula (8) can be converted to an HMG CoA reductase inhibitor, in particular, rosuvastatin or a phamnaceuti-cally acceptable salt thereof, such as rosuvastatin calcium . WE CLAIM 1. A process for preparing a 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound having the formula (3): (Formula Removed) in which R is a hydrocarbyl group, which comprises the steps of: reacting a hydroxypyrimidine compound having the formula (1): (Formula Removed) in which R is the same as above, with a compound of formula (2): (Formula Removed) in which R' is a hydrocarbyl group and X is a halogen atom, or a compound of formula (2a): (Formula Removed) in which R' has the same meaning as above, wherein the compound of formula (2) or (2a) is present in an amount of from 0.1 to 20 mol. per one mol. of the hydroxypyrimidine compound of formula (1) at a temperature of from -30 to 200°C, in the presence or absence of a solvent, and reacting the resulting reaction product with N-methyl-N-methanesulfonamide in an amount of from 0.1 to 30 mol. per one mol. of the 2-substituted pyrimidine compound at a temperature of from from -20°C to 250°C in the presence or absence of solvent; wherein both of the reaction of the hydroxypyrimidine compound with the organic sulfonyl halide or the organic sulfonic anhydride and the reaction of the resulting reaction product with N-methyl-N-methanesulfonamide are performed in the presence of a base; and thereafter optionally converting the compound of formula (3) to rosuvastatin or a pharmaceutically acceptable salt thereof. 2. The process as claimed in any one of the preceding claims optionally followed by conversion of the compound of formula (3) rosuvastatin or a pharmaceutically acceptable salt thereof.

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112-DELNP-2004-Abstract-(04-03-2010).pdf

112-DELNP-2004-Abstract-(16-11-2010).pdf

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