| Title of Invention | INCLUSION COMPLEXES OF BUTYLPHTHALIDE WITH CYCLODEXTRIN OR ITS DERIVATIVES, A PROCESS FOR THE PREPARATION OF THE SAME |
|---|---|
| Abstract | The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-β-cyclodextrin, in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others. |
| Full Text |
|---|
144-mumnp-2005-abstract(17-2-2005).pdf
144-mumnp-2005-abstract(30-10-2006).pdf
144-mumnp-2005-abstract(complete)-(30-10-2006).pdf
144-mumnp-2005-abstract(granted)-(9-9-2010).pdf
144-mumnp-2005-cancelled pages(17-2-2005).pdf
144-mumnp-2005-cancelled pages(30-10-2006).pdf
144-mumnp-2005-claims(17-2-2005).pdf
144-mumnp-2005-claims(30-10-2006).pdf
144-mumnp-2005-claims(complete)-(30-10-2006).pdf
144-mumnp-2005-claims(granted)-(9-9-2010).pdf
144-mumnp-2005-correspondence(21-5-2010).pdf
144-mumnp-2005-correspondence(26-10-2006).pdf
144-MUMNP-2005-CORRESPONDENCE(6-8-2010).pdf
144-mumnp-2005-correspondence(ipo)-(11-8-2006).pdf
144-mumnp-2005-correspondence(ipo)-(9-9-2010).pdf
144-mumnp-2005-description(complete)-(17-2-2005).pdf
144-mumnp-2005-description(complete)-(30-10-2006).pdf
144-mumnp-2005-description(granted)-(9-9-2010).pdf
144-mumnp-2005-form 1(11-3-2005).pdf
144-mumnp-2005-form 1(17-2-2005).pdf
144-mumnp-2005-form 1(26-10-2006).pdf
144-mumnp-2005-form 13(12-5-2005).pdf
144-mumnp-2005-form 18(18-3-2005).pdf
144-mumnp-2005-form 2(30-10-2006).pdf
144-mumnp-2005-form 2(complete)-(17-2-2005).pdf
144-mumnp-2005-form 2(complete)-(30-10-2006).pdf
144-mumnp-2005-form 2(granted)-(9-9-2010).pdf
144-mumnp-2005-form 2(title page)-(17-2-2005).pdf
144-mumnp-2005-form 2(title page)-(30-10-2006).pdf
144-mumnp-2005-form 2(title page)-(complete)-(30-10-2006).pdf
144-mumnp-2005-form 2(title page)-(granted)-(9-9-2010).pdf
144-mumnp-2005-form 3(11-3-2005).pdf
144-mumnp-2005-form 3(17-2-2005).pdf
144-mumnp-2005-form 3(23-10-2006).pdf
144-mumnp-2005-form 5(11-3-2005).pdf
144-mumnp-2005-form 5(17-2-2005).pdf
144-mumnp-2005-general power of attorney(16-6-2005).pdf
144-MUMNP-2005-OTHER DOCUMENT(6-8-2010).pdf
144-mumnp-2005-petition under rule 137(26-10-2006).pdf
144-mumnp-2005-power of attorney(17-6-2005).pdf
144-mumnp-2005-specification(amanded)-(17-2-2005).pdf
144-mumnp-2005-specification(amended)-(30-10-2006).pdf
| Patent Number | 242769 | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indian Patent Application Number | 144/MUMNP/2005 | |||||||||||||||||||||||||||||||||
| PG Journal Number | 38/2010 | |||||||||||||||||||||||||||||||||
| Publication Date | 17-Sep-2010 | |||||||||||||||||||||||||||||||||
| Grant Date | 09-Sep-2010 | |||||||||||||||||||||||||||||||||
| Date of Filing | 17-Feb-2005 | |||||||||||||||||||||||||||||||||
| Name of Patentee | ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO. LTD. | |||||||||||||||||||||||||||||||||
| Applicant Address | ZHONG-SHAN WEST ROAD 276, SHIJIAZHUANG, HEBEI 050051. | |||||||||||||||||||||||||||||||||
Inventors:
|
||||||||||||||||||||||||||||||||||
| PCT International Classification Number | C07D307/88 | |||||||||||||||||||||||||||||||||
| PCT International Application Number | PCT/CN2002/000579 | |||||||||||||||||||||||||||||||||
| PCT International Filing date | 2002-08-21 | |||||||||||||||||||||||||||||||||
PCT Conventions:
|
||||||||||||||||||||||||||||||||||