Indian Patents. 242656:"INTERVERTEBRAL DISK PROSTHESIS OR NUCLEUS REPLACEMENT PROSTHESIS"

Title of Invention	"INTERVERTEBRAL DISK PROSTHESIS OR NUCLEUS REPLACEMENT PROSTHESIS"
Abstract	The intervertebral prosthesis or nucleus replacement prosthesis comprises a bio-compatible pouch (1) receiving a curable, flowable material (2) containing monomers, comonomers, homopolymers, oligomers, or mixtures thereof. Curing the curable, flowable material introduced into the pouch (1) takes place in situ.

Full Text	The present invention relates to an intervertebral disk prosthesis or nucleus replacement prosthesis. A substantial number of such intervertebral disk prosthesis is already known in the state of the art, said prosthesis however all being prefabricated and requiring implantation in the prefabricated, comparatively bulky state into the intervertebral space. The above cited state of the art is merely cited to discuss the background of the present invention, but it does not imply that said cited state of the art was in fact published or known to the public at the time of this application or its priority. The objective of the present invention is to create an intervertebral disk prosthesis or nucleus replacement prosthesis allowing implantation in a comparatively dimensionally compacted stated into the intervertebral space and, after being filled with a curable, flowable substance, to be solidified by a curing procedure. The present invention solves the above problem using an intervertebral disk prosthesis comprising the features of claim 1. The still empty pouch of the intervertebral disk prosthesis is easily inserted in its collapsed state into the intervertebral space and then may be filled by means of a syringe and an appropriate cannula with a flowable mixture of monomers. The pouch (or balloon) may be fitted with a special surface and/or thickness and/or a special material such as polycarbonate urethane (PCU) or a polycarbonate so it shall make contact by its appropriate sides with the upper plates of the adjacent vertebras. This design offers the advantages that the contact surfaces of the two upper plates (cartilage layer) of the adjacent vertebras shall entail optimal conditions of sliding, biocompatibility, rigidity etc, at the involved motions (rotation, extension, flexion). By selecting appropriate pressurization, said pouch may be filled with the polymerizable mixture of monomers to such an extent that the intervertebral disk height shall once again be the appropriate anatomical initial height. In this procedure, the said material may be introduced into the pouch at an excess pressure of less than 3 atmospheres, preferably no more than 1.1 atmospheres. However said material also may be introduced into the pouch in the absence of substantial excess pressure when the affected vertebras are kept spaced apart using appropriate implements. By inserting a light guide (for instance an optical fiber cable) into the pouch, i.e. into its aperture, the polymerizable material illustratively may be photo-polymerized using blue light (for instance of 340 nm wavelength). As regards aqueous monomer solutions, polymer cross-linking may result in a hydrogel. Such a result offers the advantage that in the event of stress on the body, the hydrogel may release water, whereas in the case of the body at rest, it may absorb water. In this manner a damping effect is attained, furthermore the possibility to restore the intervertebral disk to its initial height. In a another preferred embodiment of the present invention, the pouch is double-walled and the curable, flowable material containing monomers, comonomers, homopolymers, oligomers or mixtures thereof is introduced between said two walls, as a result of which the center of the intervertebral disk prosthesis is hollow. The freely selectable size of said cavity allows additional control of implant flexibility. In yet another embodiment mode of the present invention, the pouch is chemically identical with the curable, flowable material it contains, as a result of which said latter material may combine with the pouch material. In a further embodiment mode of the invention, the pouch consists of a memory effect substance, as a result of which it assumes the geometric shape previously stored at body temperature. In yet another embodiment mode of the invention, the curable, flowable material contains a polymerization catalyst and preferably a polymerization accelerator. In yet another preferred embodiment of the invention, the curable, flowable material contains a photo-initiator, preferably a radicals-generating photo-initiator, where said photo-initiator preferably absorbs light in the 340 to 420 nm range. The photo-initiator may be phosphine oxide, preferably an acylphosphine oxide. The phospine oxide may be copolymerized with dimethylacrylamide. Blue light polymerization offers the advantage over auto-polymerization that higher heat dissipation that might destroy the protein molecule will not take place. Moreover a light guide irradiation the blue light into the balloon may be handled free of danger. The frequency and duration of blue light irradiation may be set merely by controlling the light source. The monomers, comonomers, homopolymers, oligomers or mixtures that are contained in the curable, flowable material, my be appropriately selected from the group of (a) polyethylene glycols, preferably polyethylene glycol diacrylates; (b) N-vinyl pyrrolidones; and (c) vinyls, preferably vinyl alcohols; and styrenes. (d) styrenes. The polymers prepared thereby may be varied within wide ranges as regards their elasticities. Advantageously the curable flowable material contains 30 to 160% by wt, preferably 40 to 90% by wt water. A proporation of 45 to 55% by wt water is espe7cially appropriate. By determining how much water the polymerized material - especially when it is a hydrogel -subsequently shall absorb - the swelling factor --, the additional traction on the spine segment also may be controlled. A method for manufacturing the intervertebral disk prosthesis or nucleus replacement prosthesis includes the following steps: (a) implanting a bio-compatible pouch into the intervertebral space between two adjacent vertebras, (b) introducing a curable, flowable material containing monomers, comonomers, oligomers or mixtures thereof inside the implanted, bio-compatible pouch, the filled pouch remaining centered in the intervertebral space, and (c) curing in situ the curable, flowable material in the pouch. In one variation of the method of the present invention, the pouch may be inflated with air between steps (a) and (b). By means of this preliminary traction, the tractive capacity of the spine segment may be checked. In a further variation of the method of the present invention, the pouch may be filled with an x-ray contrast means. Said contrast means makes visible the pouch in the spine segment by means of an image converter. This feature allows a check on the proper pouch position. The said material may be cured by auto-polymerization or by photo-polymerization, preferably using visible or ultraviolet light. The invention and further implementations of it are elucidated below by means of several illustrative embodiment modes which are shown in partly schematic manner. Fig. 1 is a longitudinal section of an intervertebral disk prosthesis implanted between two adjacent vertebras while the pouch is being filled with a curable and flowable material; Fig. 2 is a longitudinal section of the intervertebral disk prosthesis of Fig. 1 when the flowable material is curing; Fig. 3 is a longitudinal section of a double -wall intervertebral disk prosthesis; Fig. 4 is a longitudinal section of the filling valve of the intervertebral disk prosthesis; Fig. 5 is a longitudinal section of an intervertebral disk prosthesis comprising external surfaces of different thicknesses. Fig. 1 shows the intervertebral disk prosthesis in the form of a nucleus replacement prosthesis in the state wherein the biocompatible pouch 1 already has been implanted in the interavertebral space 10 of two adjacent vertebras 11,12 and wherein it is being filled through the valve 15 and the cannula 16 with a curable, flowable material 2 in the form of a hydrogel at the inside of the implanted biocompatible pouch 1 in the direction of the arrows 17. The filled pouch 1 remains centered in the intervertebral space 10 and rests against the two upper plates 13, 14 of the adjacent vertebras 11,12. Fig. 2 shows how the material 2 implanted in the biocompatible pouch 1 is cured by photo-polymerization by inserting a light guide 18 through the cannula 16 into said pouch. For that purpose the material 2 contains a radicals-generating photo-initiator. The light used for photo-initiation is indicated by the arrows 19 and is ultraviolet. Fig. 3 shows a variation of the intervertebral disk prosthesis wherein the pouch 1 is double-walled and the material 2 is introduced between the two walls 3, 4 entailing a hollow center 5 of the intervertebral prosthesis. To allow filling with material 2 both the single-wall as well as the double-wall variation of the intervertebral disk prosthesis, a special valve 15 shown in Fig. 4 is provided. Substantially this valve 15 comprises a central borehole 21 holding a ball 23 braced by a spring 22 and acting as a check valve, and a peripheral borehole 24 with a ball 25 braced by a spring 26 and also acting as a check valve. The central borehole 21 is used to fill the single-wall variant (shown I Figs. 1 and 2), and the peripheral variant 24 is used to fill the double-wall variant (of Fig. 3). In the latter variant, the central borehole 21 may be used to introduce air or x-ray contrast means. Fig. 5 shows a further variant of the intervertebral disk prosthesis wherein the pouch 1 comprises walls 6, 7 which shall rest against the upper plates 13,14 of the adjacent vertebras 11, 12 and are made thicker than the wall zones elsewhere. AT least the walls 6 and 7 of the pouch 1 consist of polycarbonate urethane (PCU) or of polycarbonate. Serveral illustrative embodiments of the present invention are discussed below. Example 1 45 g of polyethylene glycol diacrylate (PEGDA) having a molecular weight of 700 and 5 g of a copolymer of 2,6-dimethyl -3-vinylbenzoyl phosphine oxide (DMVBPO) and dimethyl acrylamide were dissolved in 50 g distilled water. This hydrogel was cured with blue light having wavelength of 420 nm and an intensity of 2 watt/cm2. Example 2 45 g of polyethylene glycol diacrylate (PEGDA) having a molecular weight of 700 and 5 g of a copolymer of 4-(VBPO) and dimethyl acrylamide were dissolved in 50 g distilled water. This hydrogel was cured with blue light having a wave length of 420 nm and an intensity of 2 watt/cm2. Example 3 45 g of polyethylene glycol diacrylate (PEGDA) having a molecular weight of 700 and 5 g of a copolymer of a copolymer of 2, 4, 6-trimethylbenzoyl-phenyl-4-vinylphenyl phosphine oxide (TMVPO) and dimethyl acrylamide were dissolved in 50 g distilled water, This hydrogel was cured with blue light having a wavelength of 420 nm and an intensity of 2 watt/cm2. We claim: 1. An intervertebral disk prosthesis or nucleus replacement prosthesis comprising a biocompatible pouch (1) adapted to be introduced in dimensionally compacted state into an intervertebral space, said pouch (1) being defined by opposing walls (6, 7) characterized in that said pouch (1) is adapted to be filled with a curable flowable material (2) consisting of monomers, comonomers, homopolymers, oligomers or mixtures thereof such as herein described whereby portions of said walls (6, 7) abut against the upper plates (13, 14) of adjacent vertebras (11, 12), those portions of the walls (6, 7) abutting the plates (13, 14) being thicker than other portions of the pouch walls. 2. Intervertebral disk prosthesis or nucleus replacement prosthesis as claimed in claim 1, wherein said curable, flowable material (2) is cured by one of the following curing procedures: - photo-polymerization; - auto-polymerization; or - polymerization using a polymerization catalyst and a polymerization accelerator. 3. Intervertebral disk prosthesis as claimed in claim 2, wherein the material (2) contains a photo-initiator, preferably a radicals-generating photo-initiator. 4. Intervertebral disk prosthesis as claimed in claim 3, wherein the photo-initiator absorbs light in the 340 to 420 nm range. 5. Intervertebral disk prosthesis as claimed in either of claims 3 or 4, wherein the photo-initiator is a phosphine oxide, preferably an acyl-phosphine oxide. 6. Intervertebral disk prosthesis as claimed in claim 5, wherein the phosphine oxide is copolymerized with dimethylacryl amide. 7. Intervertebral disk prosthesis as claimed in one of claims 1 to 6, wherein the monomers, comonomers, homopolymers, oligomers or mixtures thereof are selected from the group of (a) polyethylene glycols, preferably polyethylene glycol (di) acrylates; (b) N-vinylpyrrolidones; and (c) vinyls, preferably vinyl alcohols; and (d) styrenes. 8. Intervertebral disk prosthesis as claimed in any one of claims 1 to 7, wherein the material (2) contains by weight 30% to 160% water, preferably 40% to 90% water. 9. Intervertebral disk prosthesis as claimed in any one of claims 1 to 8, wherein the material (2) contains a hydrogel. 10. Intervertebral disk prosthesis as claimed in one of claims 1 to 9, wherein the pouch (1) is double-walled and the material (2) is introduced between the two walls (3, 4) whereby the intervertebral disk prosthesis center (5) is hollow. 11. Intervertebral disk prosthesis as claimed in any one of claims 1 to 10, wherein the pouch (1) is made of a memory-effect substance whereby said pouch shall assume a previously stored geometric shape at body temperature. 12. Intervertebral disk prosthesis as claimed in any one of claims 1 or 7 to 11, wherein the material (2) contains a polymerization catalyst and preferably additionally a polymerization accelerator. 13. Intervertebral disk prosthesis as claimed in any one of claims 1 to 12, wherein the pouch (1) is made of a substance which is chemically identical with the material contained in said pouch. 14. Intervertebral disk prosthesis as claimed in any one of claims 1 to 12, wherein the walls (6, 7) of the pouch (1) abutting the upper plates (13, 14) of the adjacent vertebras (11,12), consist of polycarbonate urethane (PCU) or polycarbonate.

Full Text

The present invention relates to an intervertebral disk prosthesis or nucleus replacement prosthesis.
A substantial number of such intervertebral disk prosthesis is already known in the state of the art, said prosthesis however all being prefabricated and requiring implantation in the prefabricated, comparatively bulky state into the intervertebral space.
The above cited state of the art is merely cited to discuss the background of the present invention, but it does not imply that said cited state of the art was in fact published or known to the public at the time of this application or its priority.
The objective of the present invention is to create an intervertebral disk prosthesis or nucleus replacement prosthesis allowing implantation in a comparatively dimensionally compacted stated into the intervertebral space and, after being filled with a curable, flowable substance, to be solidified by a curing procedure.
The present invention solves the above problem using an intervertebral disk prosthesis comprising the features of claim 1.
The still empty pouch of the intervertebral disk prosthesis is easily inserted in its collapsed state into the intervertebral space and then may be filled by means of a syringe and an appropriate cannula with a flowable mixture of monomers. The pouch (or balloon) may be fitted with a special surface and/or thickness and/or a special material such as polycarbonate urethane (PCU) or a polycarbonate so it shall make contact by its appropriate sides with the upper plates of the adjacent vertebras.
This design offers the advantages that the contact surfaces of the two upper plates (cartilage layer) of the adjacent vertebras shall entail optimal conditions of sliding, biocompatibility, rigidity etc, at the involved motions (rotation, extension, flexion).
By selecting appropriate pressurization, said pouch may be filled with the polymerizable mixture of monomers to such an extent that the intervertebral disk height shall once again be the appropriate anatomical initial height. In this procedure, the said material may be introduced into the pouch at an excess pressure of less than 3 atmospheres, preferably no more than 1.1 atmospheres.

However said material also may be introduced into the pouch in the absence of substantial excess pressure when the affected vertebras are kept spaced apart using appropriate implements.
By inserting a light guide (for instance an optical fiber cable) into the pouch, i.e. into its aperture, the polymerizable material illustratively may be photo-polymerized using blue light (for instance of 340 nm wavelength). As regards aqueous monomer solutions, polymer cross-linking may result in a hydrogel.
Such a result offers the advantage that in the event of stress on the body, the hydrogel may release water, whereas in the case of the body at rest, it may absorb water. In this manner a damping effect is attained, furthermore the possibility to restore the intervertebral disk to its initial height. In a another preferred embodiment of the present invention, the pouch is double-walled and the curable, flowable material containing monomers, comonomers, homopolymers, oligomers or mixtures thereof is introduced between said two walls, as a result of which the center of the intervertebral disk prosthesis is hollow. The freely selectable size of said cavity allows additional control of implant flexibility.
In yet another embodiment mode of the present invention, the pouch is chemically identical with the curable, flowable material it contains, as a result of which said latter material may combine with the pouch material.
In a further embodiment mode of the invention, the pouch consists of a memory effect substance, as a result of which it assumes the geometric shape previously stored at body temperature.
In yet another embodiment mode of the invention, the curable, flowable material contains a polymerization catalyst and preferably a polymerization accelerator.
In yet another preferred embodiment of the invention, the curable, flowable material contains a photo-initiator, preferably a radicals-generating photo-initiator, where said photo-initiator preferably absorbs light in the 340 to 420 nm range. The photo-initiator may be phosphine oxide, preferably an acylphosphine oxide. The phospine oxide may be copolymerized with dimethylacrylamide. Blue light polymerization offers the advantage over auto-polymerization that higher heat dissipation that might destroy the protein molecule will not take place. Moreover

a light guide irradiation the blue light into the balloon may be handled free of danger. The frequency and duration of blue light irradiation may be set merely by controlling the light source.
The monomers, comonomers, homopolymers, oligomers or mixtures that are contained in the curable, flowable material, my be appropriately selected from the group of
(a) polyethylene glycols, preferably polyethylene glycol diacrylates;
(b) N-vinyl pyrrolidones; and
(c) vinyls, preferably vinyl alcohols; and styrenes.
(d) styrenes.
The polymers prepared thereby may be varied within wide ranges as regards their elasticities.
Advantageously the curable flowable material contains 30 to 160% by wt, preferably 40 to 90% by wt water. A proporation of 45 to 55% by wt water is espe7cially appropriate. By determining how much water the polymerized material - especially when it is a hydrogel -subsequently shall absorb - the swelling factor --, the additional traction on the spine segment also may be controlled.
A method for manufacturing the intervertebral disk prosthesis or nucleus replacement prosthesis includes the following steps:
(a) implanting a bio-compatible pouch into the intervertebral space between two adjacent vertebras,
(b) introducing a curable, flowable material containing monomers, comonomers, oligomers or mixtures thereof inside the implanted, bio-compatible pouch, the filled pouch remaining centered in the intervertebral space, and
(c) curing in situ the curable, flowable material in the pouch.
In one variation of the method of the present invention, the pouch may be inflated with air between steps (a) and (b). By means of this preliminary traction, the tractive capacity of the spine segment may be checked.
In a further variation of the method of the present invention, the pouch may be filled with an x-ray contrast means. Said contrast means makes visible the pouch in the spine segment by means of an image converter. This feature allows a check on the proper pouch position.

The said material may be cured by auto-polymerization or by photo-polymerization, preferably using visible or ultraviolet light.
The invention and further implementations of it are elucidated below by means of several illustrative embodiment modes which are shown in partly schematic manner. Fig. 1 is a longitudinal section of an intervertebral disk prosthesis implanted between two adjacent vertebras while the pouch is being filled with a curable and flowable material; Fig. 2 is a longitudinal section of the intervertebral disk prosthesis of Fig. 1 when the flowable material is curing;
Fig. 3 is a longitudinal section of a double -wall intervertebral disk prosthesis; Fig. 4 is a longitudinal section of the filling valve of the intervertebral disk prosthesis; Fig. 5 is a longitudinal section of an intervertebral disk prosthesis comprising external surfaces of different thicknesses.
Fig. 1 shows the intervertebral disk prosthesis in the form of a nucleus replacement prosthesis in the state wherein the biocompatible pouch 1 already has been implanted in the interavertebral space 10 of two adjacent vertebras 11,12 and wherein it is being filled through the valve 15 and the cannula 16 with a curable, flowable material 2 in the form of a hydrogel at the inside of the implanted biocompatible pouch 1 in the direction of the arrows 17. The filled pouch 1 remains centered in the intervertebral space 10 and rests against the two upper plates 13, 14 of the adjacent vertebras 11,12.
Fig. 2 shows how the material 2 implanted in the biocompatible pouch 1 is cured by photo-polymerization by inserting a light guide 18 through the cannula 16 into said pouch. For that purpose the material 2 contains a radicals-generating photo-initiator. The light used for photo-initiation is indicated by the arrows 19 and is ultraviolet.
Fig. 3 shows a variation of the intervertebral disk prosthesis wherein the pouch 1 is double-walled and the material 2 is introduced between the two walls 3, 4 entailing a hollow center 5 of the intervertebral prosthesis.
To allow filling with material 2 both the single-wall as well as the double-wall variation of the intervertebral disk prosthesis, a special valve 15 shown in Fig. 4 is provided. Substantially

this valve 15 comprises a central borehole 21 holding a ball 23 braced by a spring 22 and acting as a check valve, and a peripheral borehole 24 with a ball 25 braced by a spring 26 and also acting as a check valve. The central borehole 21 is used to fill the single-wall variant (shown I Figs. 1 and 2), and the peripheral variant 24 is used to fill the double-wall variant (of Fig. 3). In the latter variant, the central borehole 21 may be used to introduce air or x-ray contrast means. Fig. 5 shows a further variant of the intervertebral disk prosthesis wherein the pouch 1 comprises walls 6, 7 which shall rest against the upper plates 13,14 of the adjacent vertebras 11, 12 and are made thicker than the wall zones elsewhere. AT least the walls 6 and 7 of the pouch 1 consist of polycarbonate urethane (PCU) or of polycarbonate.
Serveral illustrative embodiments of the present invention are discussed below.
Example 1
45 g of polyethylene glycol diacrylate (PEGDA) having a molecular weight of 700 and 5 g of a copolymer of 2,6-dimethyl -3-vinylbenzoyl phosphine oxide (DMVBPO) and dimethyl acrylamide were dissolved in 50 g distilled water. This hydrogel was cured with blue light having wavelength of 420 nm and an intensity of 2 watt/cm2.
Example 2
45 g of polyethylene glycol diacrylate (PEGDA) having a molecular weight of 700 and 5 g of a copolymer of 4-(VBPO) and dimethyl acrylamide were dissolved in 50 g distilled water. This hydrogel was cured with blue light having a wave length of 420 nm and an intensity of 2 watt/cm2.
Example 3
45 g of polyethylene glycol diacrylate (PEGDA) having a molecular weight of 700 and 5 g of a copolymer of a copolymer of 2, 4, 6-trimethylbenzoyl-phenyl-4-vinylphenyl phosphine oxide (TMVPO) and dimethyl acrylamide were dissolved in 50 g distilled water, This hydrogel was cured with blue light having a wavelength of 420 nm and an intensity of 2 watt/cm2.

We claim:
1. An intervertebral disk prosthesis or nucleus replacement prosthesis comprising a biocompatible pouch (1) adapted to be introduced in dimensionally compacted state into an intervertebral space, said pouch (1) being defined by opposing walls (6, 7) characterized in that said pouch (1) is adapted to be filled with a curable flowable material (2) consisting of monomers, comonomers, homopolymers, oligomers or mixtures thereof such as herein described whereby portions of said walls (6, 7) abut against the upper plates (13, 14) of adjacent vertebras (11, 12), those portions of the walls (6, 7) abutting the plates (13, 14) being thicker than other portions of the pouch walls.
2. Intervertebral disk prosthesis or nucleus replacement prosthesis as claimed in claim 1, wherein said curable, flowable material (2) is cured by one of the following curing procedures:

- photo-polymerization;
- auto-polymerization; or
- polymerization using a polymerization catalyst and a polymerization accelerator.

3. Intervertebral disk prosthesis as claimed in claim 2, wherein the material (2) contains a photo-initiator, preferably a radicals-generating photo-initiator.
4. Intervertebral disk prosthesis as claimed in claim 3, wherein the photo-initiator absorbs light in the 340 to 420 nm range.
5. Intervertebral disk prosthesis as claimed in either of claims 3 or 4, wherein the photo-initiator is a phosphine oxide, preferably an acyl-phosphine oxide.
6. Intervertebral disk prosthesis as claimed in claim 5, wherein the phosphine oxide is copolymerized with dimethylacryl amide.
7. Intervertebral disk prosthesis as claimed in one of claims 1 to 6, wherein the
monomers, comonomers, homopolymers, oligomers or mixtures thereof are selected
from the group of
(a) polyethylene glycols, preferably polyethylene glycol (di) acrylates;
(b) N-vinylpyrrolidones; and
(c) vinyls, preferably vinyl alcohols; and
(d) styrenes.

8. Intervertebral disk prosthesis as claimed in any one of claims 1 to 7, wherein the material (2) contains by weight 30% to 160% water, preferably 40% to 90% water.
9. Intervertebral disk prosthesis as claimed in any one of claims 1 to 8, wherein the material (2) contains a hydrogel.
10. Intervertebral disk prosthesis as claimed in one of claims 1 to 9, wherein the pouch (1) is double-walled and the material (2) is introduced between the two walls (3, 4) whereby the intervertebral disk prosthesis center (5) is hollow.
11. Intervertebral disk prosthesis as claimed in any one of claims 1 to 10, wherein the pouch (1) is made of a memory-effect substance whereby said pouch shall assume a previously stored geometric shape at body temperature.
12. Intervertebral disk prosthesis as claimed in any one of claims 1 or 7 to 11, wherein the material (2) contains a polymerization catalyst and preferably additionally a polymerization accelerator.
13. Intervertebral disk prosthesis as claimed in any one of claims 1 to 12, wherein the pouch (1) is made of a substance which is chemically identical with the material contained in said pouch.
14. Intervertebral disk prosthesis as claimed in any one of claims 1 to 12, wherein the walls (6, 7) of the pouch (1) abutting the upper plates (13, 14) of the adjacent vertebras (11,12), consist of polycarbonate urethane (PCU) or polycarbonate.

Documents:

1487-DELNP-2004-Abstract-(24-08-2009).pdf

1487-delnp-2004-abstract.pdf

1487-delnp-2004-assignments.pdf

1487-delnp-2004-claims-(12-05-2010).pdf

1487-DELNP-2004-Claims-(24-08-2009).pdf

1487-DELNP-2004-Claims-(31-05-2010).pdf

1487-delnp-2004-claims.pdf

1487-delnp-2004-Correspondence-Others-(07-04-2010).pdf

1487-DELNP-2004-Correspondence-Others-(11-04-2011).pdf

1487-delnp-2004-correspondence-others-(12-05-2010).pdf

1487-DELNP-2004-Correspondence-Others-(23-03-2010).pdf

1487-DELNP-2004-Correspondence-Others-(23-04-2010).pdf

1487-DELNP-2004-Correspondence-Others-(24-08-2009).pdf

1487-DELNP-2004-Correspondence-Others-(30-03-2010).pdf

1487-DELNP-2004-Correspondence-Others-(31-05-2010).pdf

1487-DELNP-2004-Correspondence-Others-04-04-2008.pdf

1487-DELNP-2004-Correspondence-Others-28-04-2008.pdf

1487-delnp-2004-correspondence-others.pdf

1487-DELNP-2004-Description (Complete)-(24-08-2009).pdf

1487-delnp-2004-description (complete).pdf

1487-DELNP-2004-Drawings-(24-08-2009).pdf

1487-DELNP-2004-Drawings-(31-05-2010).pdf

1487-delnp-2004-drawings.pdf

1487-delnp-2004-Form-1-(07-04-2010).pdf

1487-delnp-2004-form-1-(12-05-2010).pdf

1487-DELNP-2004-Form-1-(24-08-2009).pdf

1487-delnp-2004-form-1.pdf

1487-delnp-2004-form-13-(04-04-2008).pdf

1487-delnp-2004-form-18.pdf

1487-DELNP-2004-Form-2-(24-08-2009).pdf

1487-delnp-2004-form-2.pdf

1487-DELNP-2004-Form-26-04-04-2008-Form-26-04-04-2008.pdf

1487-DELNP-2004-Form-27-(11-04-2011).pdf

1487-delnp-2004-Form-3-(07-04-2010).pdf

1487-DELNP-2004-Form-3-(24-08-2009).pdf

1487-delnp-2004-form-3.pdf

1487-delnp-2004-form-6.pdf

1487-DELNP-2004-GPA-(23-03-2010).pdf

1487-DELNP-2004-GPA-(30-03-2010).pdf

1487-delnp-2004-gpa.pdf

1487-delnp-2004-pct-210.pdf

1487-DELNP-2004-Petition 137-(11-04-2011).pdf

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Patent Number

242656

Indian Patent Application Number

1487/DELNP/2004

PG Journal Number

37/2010

Publication Date

10-Sep-2010

Grant Date

03-Sep-2010

Date of Filing

31-May-2004

Name of Patentee

SYNTHES GMBH.,

Applicant Address

EIMATTSTRASSE 3, CH-4436 OBERDORF, SWITZERLAND.

Inventors:

#	Inventor's Name	Inventor's Address
1	ARMIN STUDER	THEATERSTRASSE 34, CH-8400 WINTERTHUR, SWITZERLAND

PCT International Classification Number

A61F2/44

PCT International Application Number

PCT/CH01/00700

PCT International Filing date

2001-12-05

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	PCT/CH01/00700	2001-12-05	Switzerland