| Title of Invention | AN IMPROVED METHOD FOR MANUFACTURE OF 4-HYDROXY PYRAN-2-ONE DERIVATIVES |
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| Abstract | A process for preparation of 4-hydroxy-pyran-2-one derivative of formula (I), and wherein R¹ and R² are methyl and R³ is hydrogen or methyl, comprising the steps of, heating a compound of formula (II), wherein R is as defined before, and R4 is hydrogen, NH4+ or an alkali metal, 29 in a solvent mixture consisting of an aromatic hydrocarbon and a ketone in an inert atmosphere at a temperature of between 60°C to 92°C in the absence or presence of orthophosphoric acid or its alkali dihydrogen salts or alkali hydrogen salts of a dibasic acid, followed by optional neutralization of the reaction mixture with an organic base and obtaining compound of formula (I) in high purity and substantially free of impurities through a step of isolation and crystallization. The process leads to formation of derivatives of formula I in high purity with dimmer impurity (III) less than 0.1% and anhydro impurity (IV) below 0.15%. |
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1137-MUMNP-2006-ABSTRACT(23-12-2009).pdf
1137-mumnp-2006-abstract(granted)-(8-6-2010).pdf
1137-mumnp-2006-annexure to form 3(20-11-2006).pdf
1137-MUMNP-2006-ANNEXURE TO FORM 3(23-12-2009).pdf
1137-mumnp-2006-annexure to form 3(26-2-2007).pdf
1137-mumnp-2006-annexure to form 3(3-9-2007).pdf
1137-MUMNP-2006-CANCELLED PAGE(23-12-2009).pdf
1137-MUMNP-2006-CLAIMS(AMENDED)-(23-12-2009).pdf
1137-mumnp-2006-claims(granted)-(8-6-2010).pdf
1137-mumnp-2006-correspondance-received.pdf
1137-MUMNP-2006-CORRESPONDENCE(15-4-2009).pdf
1137-MUMNP-2006-CORRESPONDENCE(19-1-2009).pdf
1137-mumnp-2006-correspondence(19-12-2005).pdf
1137-MUMNP-2006-CORRESPONDENCE(2-3-2010).pdf
1137-MUMNP-2006-CORRESPONDENCE(23-12-2009).pdf
1137-MUMNP-2006-CORRESPONDENCE(29-9-2008).pdf
1137-mumnp-2006-correspondence(ipo)-(1-7-2010).pdf
1137-mumnp-2006-description (complete).pdf
1137-MUMNP-2006-FORM 1(23-12-2009).pdf
1137-mumnp-2006-form 18(14-1-2008).pdf
1137-mumnp-2006-form 2(granted)-(8-6-2010).pdf
1137-MUMNP-2006-FORM 2(TITLE PAGE)-(23-12-2009).pdf
1137-mumnp-2006-form 2(title page)-(granted)-(8-6-2010).pdf
1137-MUMNP-2006-OTHER DOCUMENT(15-4-2009).pdf
1137-MUMNP-2006-OTHER DOCUMENT(23-12-2009).pdf
1137-MUMNP-2006-REPLY TO EXAMINATION REPORT(23-12-2009).pdf
1137-MUMNP-2006-SPECIFICATION(AMENDED)-(23-12-2009).pdf
| Patent Number | 240888 | |||||||||||||||
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| Indian Patent Application Number | 1137/MUMNP/2006 | |||||||||||||||
| PG Journal Number | 24/2010 | |||||||||||||||
| Publication Date | 11-Jun-2010 | |||||||||||||||
| Grant Date | 08-Jun-2010 | |||||||||||||||
| Date of Filing | 25-Sep-2006 | |||||||||||||||
| Name of Patentee | LUPIN LTD. | |||||||||||||||
| Applicant Address | 159, CST Road, Kalina, Santacruz (East), Mumbai- 400 098, | |||||||||||||||
Inventors:
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| PCT International Classification Number | C07D309/30 | |||||||||||||||
| PCT International Application Number | PCT/IN2004/000075 | |||||||||||||||
| PCT International Filing date | 2004-03-30 | |||||||||||||||
PCT Conventions:
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