Title of Invention

"PHARMACEUTICAL PREPARATION CONTAINING GABAPENTIN"

Abstract A gabapentin granulate obtained by granulating gabapentin with PEG having a melting point comprised between 50 and 80°C and pharmaceutical compositions containing it, are described.
Full Text PHARMACEUTICAL PREPARATION CONTAINING GABAPENTIN
Description
The present invention relates to a pharmaceutical composition containing gabapentin. Gabapentin is the common name of the 1-aminomethyl-cyclohexane-acetic acid, a known drug with anti-epileptic activity.
The drug is not protected by patent, nevertheless in the US patent n. 6.054.482 in the name of Godecke AG stable pharmaceutical compositions of gabapentin are claimed which maintain, for one year at 25° C and 60% r. h., the content of the corresponding lactam (a known toxic product which can be generated by gabapentin by dehydration) lower than 0.5% by weight and which have a content of anions of mineral acids lower than 20 ppm. In the same patent a series of additives, which have to be avoided in the composition because they favour the formation of lactam, is listed as well. They are: modified cornstarch, croscarmellose sodium, glyceric esters of behenic acid, copolymers of metacrylic acid (type A and C), anion-exchange resins, titanium dioxide, silica gel and PEG with low molecular weight.
On the contrary, in the US patent n. 6.531.509 in the name of Teva Pharmaceuticals Industries Ltd. it is reported that the invention described in the GSdecke AG patent mentioned above is wrong and that stable compositions of gabapentin can be obtained even when the content of anions of mineral acids in the latter is greater than 20 ppm. However, no data are provided in this regard, nor the criteria for choosing suitable additives are shown.
In the patent application n. WO 02/26263 in the name of Sigmapharm stable compositions of gabapentin are described containing a stabilizer comprising a compound able to reduce the ionic strength, and at least 20 ppm of one anion of mineral acid.
The stabilizers belong to the following classes: volatile alcohols, non-volatile alcohols, nonvolatile liquids, water miscible solids or liquids, immiscible solids or liquids, liquid or solid surface active agents, antioxidants, ketones or aldehydes.
Currently, gabapentin is proposed with different dosages and in two pharmaceutical forms for oral use: capsules and tablets. Nevertheless, the industrial production of gabapentin tablets has several drawbacks due to

the difficulty of compressing the raw material.
Therefore, it is necessary to use the new granulation.
However, this procedure too is not deprived of practical problems since by granulating with
water, under different experimental conditions and with different procedures, the formation
of a hydrate is always obtained, with consequent loss in the original crystalline structure.
An industrial granulation with organic solvents puts some limitations by obliging to use
particular plants to protect operators and environment.
Now we have found that the problems mentioned above are overcome by granulating
gabapentin with PEG (polyethylene glycol) with a melting point comprised between 50 and
80°C.
Therefore, it is an object of the present invention a gabapentin granulate obtained by
granulating gabapentin with PEG having a melting point comprised between 50 and 80°C.
The so-obtained granulate can be used as such for preparing tablets or it can be
supplemented with other additives and then compressed.
If desired, it is also possible to add to gabapentin and to PEG, before the granulation,
additives useful for the subsequent compression or for the disgregation of the tablet such as
glydants or disgregants, specific examples being the silica gel, the pregelatinized starch and
the croscarmellose sodium.
It is important noting that in the US patent n. 6.054.482 mentioned above said substances are
included in the ones designated as destabilizing substances of the active principle. On the
contrary, we have not noticed any significative degradation of gabapentin (calculated
through the quantity of the lactam which has formed) when formulated starting from a
granulate according to the present invention and when it contained less or more 20 ppm of an
anion of a mineral acid.
Therefore, it is a second object of the present invention a gabapentin granulate obtained by
granulating the gabapentin with PEG having the melting point comprised between 50 and
80°C and additives chosen among glydants, disgregants and diluents.
Preferably, and this constitutes an additional object of the invention, the granulate will
contain a high quantity of gabapentin, for example higher than 80% by weight or even higher

than 90% by weight and it can reach even 98% by weight, the remaining 2% being the PEG. The usable PEG is the one commonly used in the pharmaceutical field and it is not necessary using particular pure PEGs. If desired, PEG mixtures with different average molecular weight can be used so that the melting point of the mixture is comprised between 50 and 80°C. Hereinafter under the PEG term, a single PEG or a PEG mixture having the melting point comprised between 50 and 80°C will be designated indifferently. The granulate can be prepared by using rotogranulators available on the market, such as, for example, the fast rotogranulators (high shear mixer) produced by the Zanchetta firm, Rotojunion 10 model, or similar devices such as Glatt, Collette, Diosna. The pharmaceutical compositions in tablets can be prepared by direct compression of the granulate or by adding to the granulate, before the compression, additives of typical pharmaceutical use which give to the tablet properties useful both in the industrial preparation and in the regular therapeutic effect of the drug administered therewith. Examples of such additives are disgregants, lubricants and glydants. Usually, when one wishes to add other additives to the granulate, the composition of the tablet resulting from the mixture compression will be comprised within the following values:
granulate 70-100% by weight, preferably 80-100%
additives 0-30% by weight, preferably 0-20%
Therefore, it is an object of the present invention gabapentin tablets containing between 70 and 100% by weight of a granulate as described above and between 0 and 30% by weight, preferably between 0 and 20% of additives for pharmaceutical use.
Since the granulate of the invention does not cause the degradation of the active principle and since one of the gabapentin pharmaceutical forms for oral use is constituted by capsules containing it, the granulate itself can be used successfully for the preparation of capsules. Therefore, it is a further object of the present invention the use of the granulate as described above for the preparation of gabapentin capsules and the capsules containing it. In order to better illustrate the present invention, the following examples are now provided.

Example 1
General procedure for the granulate preparation
A mixture of powders constituted by gabapentin, PEG and, in case, other additives is
charged in a Zanchetta rotogranulator, Rotojunior 10 model.
The total amount of powders which can be charged in the apparatus mentioned above is
comprised between 0.8 and 3 kg and 1-2 kg are preferably charged.
The powders are mixed in the rotogranulator for 5 minutes at 25°C, the blade speed being
100 rpm.
Then, the mixture under stirring is heated until the PEG melting point (between 50 and
80°C) with the blade speed comprised between 150 and 400 rpm, preferably 300 rpm, and
the crusher speed comprised between 600 and 1200 rpm, preferably, 1000 rpm. It is left for a
time comprised between 30 and 60 minutes, preferably 45 minutes.
The mixture is then cooled at 25°C by keeping it under stirring with the blade speed of 100
rpm and the crusher speed of 1000 rpm.
The so-obtained granulated is discharged which, independently from the quantity of the
introduced materials, can have a composition comprised within the following values:
Gabapentin 70-98% by weight
PEG 2-25% by weight
Additives 0-20% by weight
the total being 100%.
Example 2
With the procedure described in the example 1 the granulates having the following composition have been prepared: Grl
Gabapentin 90%
PEG 6000 6%
Modified cornstarch 4%
Gr2

Gabapentin 88%
PEG 4000 2%
Modified cornstarch 10%
Gr3
Gabapentin 90%
PEG 1500 1%
PEG 4000 4%
Croscarmellose sodium 5%
The so-produced granulates have optimum sliding and compressibility properties (rest angle
30-35% and Carr index 10-18%); the appearance of gabapentin degradation products is not
found and, from the FT-Raman analysis, the gabapentin keeps its original crystalline form.
Example 3
The granulates according to the invention can be used for obtaining pharmaceutical tablets
by using usual compressors.
The mixtures suitable for obtaining tables are comprised in the following values:
granulate 70-100% by weight
additives 0-30% by weight
Co 1
Gr 1 granulate (see example 2) 85%
pregelatinized starch 13.5%
colloidal silica 0.5%
stearate magnesium 0.5%
titanium dioxide 0.5%
Co 2
Gr 3 granulate 87%
croscarmellose sodium 11.5%
colloidal silica 0.5%
stearate magnesium 0.5%
titanium dioxide 0.5%

Co 2
Gr 2 granulate 85%
copolymer of the metacrylic acid (type C) 10%
stearate magnesium 0.5%
titanium dioxide 0.5%
glyceric esters of the behenic acid 4%
Co 4
The Gr 1 granulate described in the example 2 is compressed without adding additional additives to obtain tablets.
Co 5
Gr 1 granulate 99%
colloidal silica 0.5%
stearate magnesium 0.5%
Co 6
Gr 3 granulate 85%
PEG 4000 5%
copolymer of the metacrylic acid (type A) 10%
The so-obtained tablets show technological properties suitable for a pharmaceutical use
(hardness 10-12 Kn, friability usually crystalline form. They are also suitable for a subsequent possible coating.
Example 4
The granulates identified as Gr 1 and Gr 2 in the example 2 have been used separately to fill-in gelatine capsulae by obtaining gabapentin pharmaceutical forms in capsules (Cap 1 and Cap 2). Similarly, capsules containing the following compositions have been prepared:
Cap 3
Gr 1 granulate 95%
cornstarch 4.5%

colloidal silica 0.5%
Cap 4
Gr 3 granulate 98.5%
glyceril behenate 0.5%
colloidal silica 1%
Cap 5
Gr 1 granulate 86%
croscarmellose sodium 10%
titanium dioxide 1%
cornstarch 4.5%

Claims
1. A gabapentin granulate obtained by granulating gabapentin with PEG having a melting
point comprised between 50 and 80°C.
2. The granulate according to claim 1, wherein the gabapentin is present in an amount
higher than 80% by weight.
3. A granulate according to claim 1, wherein the gabapentin is present in quantities higher
than 90% by weight.
4. A granulate according to claim 1, wherein the gabapentin is present in quantities equal
to 98% by weight, the PEG being 2%.
5. A gabapentin pharmaceutical composition under tablet form obtained by compressing a
granulate according to claim 1.
6. A gabapentin pharmaceutical composition under capsule form obtained by filling-in a
gelatine capsule with a granulate according to claim 1.

7. A gabapentin pharmaceutical composition under the tablet form obtained by compressing
a granulate according to claim 1 and known additives useful for the preparation of tablets.
8. A gabapentin pharmaceutical composition under tablet form according to claim 7, wherein
the additives are chosen among diluents, lubricants, disgregants and glydants.
9. A gabapentin pharmaceutical composition under tablet form according to claim 7, wherein
the additives represent between 0 and 30% by weight and preferably between 0 and 20% by
weight of the tablet, the remaining to 100% being a granulate of claim 1.
10. A gabapentin pharmaceutical composition under capsule form obtained by filling-in a
gelatine capsule with a granulate according to claim 1 and known additives useful for the
preparation of pharmaceutical forms in capsule.
11. A gabapentin pharmaceutical composition under the capsule form according to claim 10,
wherein the additives represent between 0 and 30% by weight and preferably between 0 and
20% by weight of the capsule content, the remaining to 100% being a granulate of claim 1.
12. A gabapentin granulate obtained by granulating gabapentin with PEG having a melting
point comprised between 50 and 80°C and additives known for the preparation of solid
pharmaceutical forms chosen among tablets and capsules.

13. A gabapentin granulate obtained by granulating gabapentin according to claim 12,
wherein the additives are chosen among diluents, lubricants, disgregants and glydants.
14. A granulate according to claim 12 having the following composition:
gabapentin 80-98% by weight
PEG 2-25% by weight
additives 0-20% by weight
15. A gabapentin pharmaceutical composition under tablet form obtained by compressing a
granulate according to claim 12.
16. A gabapentin pharmaceutical composition under capsule form obtained by filling-in a
gelatine capsule with a granulate according to claim 12.

17. A gabapentin chemical composition under tablet or capsule form containing a granulate
according to claim 1.
18. A gabapentin chemical composition under tablet or capsule form containing a granulate
according to claim 12.


Documents:

2021-CHENP-2006 CORRESPONDENCE OTHERS 28-01-2010.pdf

2021-CHENP-2006 CORRESPONDENCE OTHERS.pdf

2021-CHENP-2006 CORRESPONDENCE PO.pdf

2021-CHENP-2006 FORM 18.pdf

2021-CHENP-2006 OTHER PATENT DOCUMENT 14-08-2009.pdf

2021-chenp-2006-abstract.pdf

2021-chenp-2006-claims.pdf

2021-chenp-2006-correspondnece-others.pdf

2021-chenp-2006-description(complete).pdf

2021-chenp-2006-form 1.pdf

2021-chenp-2006-form 3.pdf

2021-chenp-2006-form 5.pdf

2021-chenp-2006-pct.pdf


Patent Number 238924
Indian Patent Application Number 2021/CHENP/2006
PG Journal Number 10/2010
Publication Date 05-Mar-2010
Grant Date 26-Feb-2010
Date of Filing 08-Jun-2006
Name of Patentee ZAMBON GROUP S.P.A.
Applicant Address Via della Chimica, 9, I-36100 VICENZA
Inventors:
# Inventor's Name Inventor's Address
1 RAMPOLDI, Luca Via Verdi, 5, I-20020 LAINATE
2 GRASSANO, Alessandro Via Volturno, 21, I-20052 MONZA (Milano),
PCT International Classification Number A61K31/00
PCT International Application Number PCT/EP2004/053233
PCT International Filing date 2004-12-02
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 MI2003A002399 2003-12-09 Italy