| Title of Invention | N-BRIDGED SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF |
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| Abstract | This invention provides a class of androgen receptor targeting agents (ARTA) The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy, and/or g) decreasing the incidence of, halting or causing a regression of prostate cancer. |
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19-CHENP-2005 FORM-13 10-02-2010.pdf
19-CHENP-2005 CORRESPONDENCE OTHERS.pdf
19-CHENP-2005 CORRESPONDENCE PO.pdf
19-CHENP-2005 DESCRIPTION (COMPLETE).pdf
19-CHENP-2005 POWER OF ATTORNEY.pdf
| Patent Number | 238907 | |||||||||||||||
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| Indian Patent Application Number | 19/CHENP/2005 | |||||||||||||||
| PG Journal Number | 10/2010 | |||||||||||||||
| Publication Date | 05-Mar-2010 | |||||||||||||||
| Grant Date | 25-Feb-2010 | |||||||||||||||
| Date of Filing | 18-Jan-2005 | |||||||||||||||
| Name of Patentee | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | |||||||||||||||
| Applicant Address | 1534 White Avenue, Suite 403, Knoxville, TN 37996-1527 | |||||||||||||||
Inventors:
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| PCT International Classification Number | C07 C 233/05 | |||||||||||||||
| PCT International Application Number | PCT/US2003/16219 | |||||||||||||||
| PCT International Filing date | 2003-06-17 | |||||||||||||||
PCT Conventions:
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