Title of Invention

AMYLOID B(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF

Abstract The invention relates to neuromodulatory oligomers of the amyloid-$g(b)(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-beta(1-42) proteins, the production and use thereof.
Full Text

Documents:

1728-CHENP-2005 ABSTRACT.pdf

1728-CHENP-2005 CLAIMS.pdf

1728-CHENP-2005 CORRESPONDENCE OTHERS.pdf

1728-CHENP-2005 CORRESPONDENCE PO.pdf

1728-CHENP-2005 DESCRIPTION (COMPLETE).pdf

1728-CHENP-2005 DRAWINGS.pdf

1728-CHENP-2005 FORM 1.pdf

1728-CHENP-2005 FORM 18.pdf

1728-CHENP-2005 FORM 3.pdf

1728-CHENP-2005 FORM 5.pdf

1728-CHENP-2005 PCT.pdf

1728-CHENP-2005 PETITIONS.pdf

1728-CHENP-2005 POWER OF ATTORNEY.pdf


Patent Number 238777
Indian Patent Application Number 1728/CHENP/2005
PG Journal Number 9/2010
Publication Date 26-Feb-2010
Grant Date 19-Feb-2010
Date of Filing 28-Jul-2005
Name of Patentee ABBOTT GMBH & CO. KG
Applicant Address Max-Planck-Ring 2, 65205 Wiesbaden
Inventors:
# Inventor's Name Inventor's Address
1 HILLEN, Heinz Max-Planck-Strasse 17, 67454 Hassloch
2 STRIEBINGER, Andreas Ziegelofenweg 46A, 67346 Speyer
3 KRANTZ, Carsten Kopernikusstrasse 48, 68165 Mannheim
4 MOELLER, Achim Im Zaunr├╝cken 10, 67269 Grunstadt
5 MUELLER, Reinhold Ostring 66A, 67105 Schifferstadt
PCT International Classification Number C07K 14/47
PCT International Application Number PCT/EP2004/000927
PCT International Filing date 2004-02-02
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 103 03 974.0 2003-01-31 Germany