| Title of Invention | "A METHOD OF MAKING A COMPOUND OF FORMULA LA, IB OR IC" |
|---|---|
| Abstract | Natural and synthetic compounds having a lactone structure methods for using and making the compounds have been disclosed. The compounds are useful as anti-bacterial, anti-fungal and anti-inflammatory agents, and for treating proliferation disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. The compounds are also effective for treatment or prevention of inflammatory diseases such as artherosclerosis, lung fibrosis, systemic lupus erythematosus, pancreatitis, sarcoidosis, glomerulitis, and organ transplant rejection. They are also effective for treatment or prevention of bacterial and fungal infections, including treatment of peptic ulcers, gast... |
| Full Text | DESCRIPTION (COMPLETE) OCR NOT PREPARE DUE TO PRINT PROBLEM WE CLAIM: 1. A method of making a compound of Formula la, lb, or Ic (Formula Removed) wherein R1-R6 taken independently are a hydrogen atom or a group orgrouping selected from the group consisting of alkyl, substituted alkyl, allyl, substituted allyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, halo, hydroxyl, alkoxy, substituted alkoxy, alloxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, sulfonyl, substituted sulfonyl, sulfonic acid, phosphoryl, substituted phosphoryl, phosphonyl, substituted phosphonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, aminoacid, peptide, and polypeptide groups; Z and X are heteratoms selected from the group consisting of oxygen, sulfur, and nitrogen groupings in linear, branched, or cyclic structural formats; which comprises: a) providing a precursor having a lactone structure, and b) reacting the precursor with one or more chemical reagents to provide a product having one of formulae la, lb, and Ic. 2. The method as claimed in claim 1, wherein the precursor has the structure of Formula II (Formula Removed) wherein R1 and R2 taken independently are a hydrogen atom or a group or grouping selected from the group consisting of alkyl, substituted alkyl, allyl, substituted allyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, halo, hydroxyl, alkoxy, substituted alkoxy, alloxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, sulfonyl, substituted sulfonyl, sulfonic acid, phosphoryl, substituted phosphoryl, phosphonyl, substituted phosphonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, aminoacid, peptide, and polypeptide groups. 3. An isolated or synthetic compound of formula la, lb or Ic, as claimed in claim 1. 4. The compounds of formula la, lb and Ic as claimed in claim 1 selected from the group consisting of compounds 1-50 5. A pharmaceutical composition comprising a lactone compound of formula la, lb or Ic, as claimed in claim 1, or a pharmaceutically acceptable salt or hydrate thereof, in combination with a physiologically acceptable carrier. 6. The pharmaceutical composition as claimed in claim 5, wherein the lactone compound is selected from the group consisting of compounds 1-50 as claimed in claim 4. |
|---|
1891-delnp-2005-complete specification (granted).pdf
1891-delnp-2005-correspondence-others.pdf
1891-delnp-2005-correspondence-po.pdf
1891-delnp-2005-descreption (complete).pdf
1891-delnp-2005-petition-138.pdf
| Patent Number | 238668 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Indian Patent Application Number | 1891/DELNP/2005 | ||||||||
| PG Journal Number | 9/2010 | ||||||||
| Publication Date | 26-Feb-2010 | ||||||||
| Grant Date | 16-Feb-2010 | ||||||||
| Date of Filing | 05-May-2005 | ||||||||
| Name of Patentee | MAGNACHEM INTERNATIONAL LABORTORIES,INC., | ||||||||
| Applicant Address | 621 NW 53ST, SUITE 240, BOCA RATON, FLORIDA 33134,UNITED STATE OF AMERICA. | ||||||||
Inventors:
|
|||||||||
| PCT International Classification Number | A61K 31/34 | ||||||||
| PCT International Application Number | PCT/US2003/035468 | ||||||||
| PCT International Filing date | 2003-11-05 | ||||||||
PCT Conventions:
|
|||||||||