| Title of Invention | ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF |
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| Abstract | An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a) is ofIgG1 isotype, b) shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c) inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody, and d) shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 µM in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody has improved properties in antitumor therapy |
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103-CHENP-2006 CORRESPONDENCE OTHERS.pdf
103-CHENP-2006 CORRESPONDENCE PO.pdf
103-CHENP-2006 DESCRIPTION (COMPLETE).pdf
103-CHENP-2006 POWER OF ATTORNEY.pdf
| Patent Number | 238176 | ||||||||||||||||||||||||||||||
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| Indian Patent Application Number | 103/CHENP/2006 | ||||||||||||||||||||||||||||||
| PG Journal Number | 5/2010 | ||||||||||||||||||||||||||||||
| Publication Date | 29-Jan-2010 | ||||||||||||||||||||||||||||||
| Grant Date | 22-Jan-2010 | ||||||||||||||||||||||||||||||
| Date of Filing | 09-Jan-2006 | ||||||||||||||||||||||||||||||
| Name of Patentee | F. HOFFMANN-LA ROCHE AG | ||||||||||||||||||||||||||||||
| Applicant Address | Grenzacherstrasse 124, CH-4070 Basel (CH) | ||||||||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | C07K 16/28 | ||||||||||||||||||||||||||||||
| PCT International Application Number | PCT/EP04/07562 | ||||||||||||||||||||||||||||||
| PCT International Filing date | 2004-07-09 | ||||||||||||||||||||||||||||||
PCT Conventions:
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