Title of Invention

ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF

Abstract An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a) is ofIgG1 isotype, b) shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c) inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody, and d) shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 ┬ÁM in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody has improved properties in antitumor therapy
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Documents:

103-CHENP-2006 ABSTRACT.pdf

103-CHENP-2006 CLAIMS.pdf

103-CHENP-2006 CORRESPONDENCE OTHERS.pdf

103-CHENP-2006 CORRESPONDENCE PO.pdf

103-CHENP-2006 DESCRIPTION (COMPLETE).pdf

103-CHENP-2006 DRAWINGS.pdf

103-CHENP-2006 FORM-1.pdf

103-CHENP-2006 FORM-18.pdf

103-CHENP-2006 FORM-3.pdf

103-CHENP-2006 FORM-5.pdf

103-CHENP-2006 PCT.pdf

103-CHENP-2006 PETITIONS.pdf

103-CHENP-2006 POWER OF ATTORNEY.pdf

EXAMINATION REPORT REPLY.PDF


Patent Number 238176
Indian Patent Application Number 103/CHENP/2006
PG Journal Number 5/2010
Publication Date 29-Jan-2010
Grant Date 22-Jan-2010
Date of Filing 09-Jan-2006
Name of Patentee F. HOFFMANN-LA ROCHE AG
Applicant Address Grenzacherstrasse 124, CH-4070 Basel (CH)
Inventors:
# Inventor's Name Inventor's Address
1 GRAUS, Yvo Werdorperwaard 3, NL-3984 PR Odijk (NL).
2 KOPETZKI, Erhard Kastnerhofstr. 21, 82377 Penzberg (DE).
3 KUENKELE, Klaus-Peter Karwendelstrasse 9, 83671 Benediktbeuern (DE).
4 MUNDIGL, Olaf Tassiloring 16, 82362 Weilheim (DE).
5 PARREN, Paul Werdorperwaard 17, NL-3984 PR Odijk (NL).
6 REBERS, Frank Adriaan Menninckkwartier 34, NL-3554 CT Utrecht (NL).
7 SCHUMACHER, Ralf Hochfeldstrasse 78, 82377 Penzberg (DE).
8 VAN DE WINKEL, Jan Verlengde Slotlaan 80, NL-3707 CK Zeist (NL).
9 VAN VUGT, Martine Fluweelmos 6, NL-3994 KR Houten (NL).
PCT International Classification Number C07K 16/28
PCT International Application Number PCT/EP04/07562
PCT International Filing date 2004-07-09
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 03015526.1 2003-07-10 EUROPEAN UNION