Title of Invention

"PROCESS FOR THE CARBONYLATION OF A C1 TO C4 ALKYL ALCOHOL AND/OR A REACTIVE DERIVATIVE THEREOF"

Abstract

A process for the carbonylation of a C1 to C4 alkyl alcohol and/or a reactive derivative thereof which process comprises contacting a C1 to C4 alkyl alcohol and/or a reactive derivative thereof with carbon monoxide in a liquid reaction composition in a carbonylation reactor characterised in that the liquid reaction composition comprises: (a) a rhodium catalyst, (b) an alkyl halide, and (c) as promoter, at least one of ruthenium and osmium.

Full Text

The present invention relates to a carbonylation process and in particular to a process for the carbonylation of a C1 to C4 alcohol and/or a reactive derivative thereof in the presence of a rhodium catalyst and an alkyl halide. Carbonylation processes in the presence of rhodium catalysts are known and are described, for example, in US 3769329, GB 1468940, GB 1538783 and EP 0087070. Carbonylation processes in the presence of ruthenium and osmium catalysts are also known. Thus, UK patent GB 1234641 describes a process for the production of an organic acid or an ester by carbonylation of an alcohol, halide, ester, ether or phenol in the presence of a noble metal catalyst selected from iridium, platinum, palladium, osmium and ruthenium and their compounds and a promoter which is a halogen or halogen compound. According to Jenner et al in J. Mol. Catalysis 40 (1987) 71-82 ruthenium compounds are effective carbonylation catalysts for converting primary alcohols into acids and esters at high CO pressures. In the reported experiments standard conditions were 450 bar CO pressure and low CO pressures were said to lead to high yields of hydrocarbons and a lower yield of ester UK patent application GB 2029409 describes a process for the preparation of aliphatic carboxylic acids and esters by reacting carbon monoxide with alcohols at an elevated pressure of 34 atmospheres or greater in the presence of a ruthenium catalyst and halogen-containing promoter. US 4046807 relates to a process for preparing acetic anhydride from acetic acid methyl ester and carbon monoxide in the presence of a Group VIII noble metal catalyst selected from ruthenium, rhodium, palladium, osmium, iridium and platinum. The technical problem to be solved is to provide an improved process for the carbonylation of a C1 to C4 alkyl alcohol and/or a reactive derivative thereof in the presence of a rhodium catalyst and alkyl halide. According to the present invention there is provided a process for the carbonylation of a C1 to d, alkyl alcohol and/or a reactive derivative thereof which process comprises contacting a C1 to C4 alkyl alcohol and/or a reactive derivative thereof with carbon monoxide at a temperature in the range 130 to 250°C and a pressure in the range 1 to 100 barg in a liquid reaction composition in a carbonylation reactor, the liquid reaction composition comprises: (a) a rhodium catalyst, (b) an alkyl halide, and (c) as promoter, at least one of ruthenium and osmium. Thus, according to the present invention there is provided a process for the carbonylation of a C1 to C4 alkyl alcohol and/or a reactive derivative thereof which process comprises contacting a C1 to C4 alkyl alcohol and/or a reactive derivative thereof with carbon monoxide in a liquid reaction composition in a carbonylation reactor characterised in that the liquid reaction composition comprises: (a) a rhodium catalyst, (b) an alkyl halide, and (c) as promoter, at least one of ruthenium and osmium. The carbonylation product of the present invention comprises the corresponding carboxylic acid, alkyl ester and/or carboxylic ado" anhydride. Thus, the corresponding carboxylic acid product of an alkyl alcohol having n carbon atoms is a carboxylic acid having n+1 carbon atoms. The corresponding ester product of an alkyl alcohol having n carbon atoms is an ester of a carboxylic acid having n+1 carbon atoms with the alcohol reactant. The corresponding carboxylic acid anhydride product of an alkyl alcohol having n carbon atoms is the anhydride of the carboxylic acid having n+1 carbon atoms. Preferably, acetic acid, methyl acetate and/or acetic anhydride are produced in the process of the present invention by the carbonylation of methanol and/or a reactive derivative thereof. Preferably, methanol and/or methyl acetate are used as reactants. Acetic acid may be produced using the process of the present invention by the carbonylation of methanol and/or reactive derivatives of methanol including methyl acetate, dimethyl ether and methyl iodide. Acetic anhydride may be produced in the process of the present invention by the carbonylation, under substantially anhydrous conditions, of methyl acetate and/or dimethyl ether optionally with methanol and/or water present in the reactant feed to the reactor. Carboxylic acid may be produced as a carbonylation product of the process of the present invention when at least a finite concentration of water is present in the liquid reaction composition that is at least 0.1% by weight. The water may be formed in situ in the liquid reaction composition, for example, by the esterification reaction between alcohol reactant and carboxylic acid product. Also, water may be introduced to the carbonylation reactor together with or separately from other components of the liquid reaction composition. Water may be separated from other components of the reaction composition withdrawn from the reactor and may be recycled in controlled amounts to maintain the concentration of water in the liquid reaction composition. Suitably, the water concentration in the liquid reaction composition is in the range 0.1 to 15% by weight. Preferably, the concentration of water in the liquid reaction composition is maintained below 14% by weight, more preferably below 11 % by weight, most preferably below 7% by weight. Carboxylic anhydride may be produced as the carbonylation product of the process of the present invention optionally with carboxylic acid by ensuring that the liquid reaction composition is maintained under substantially anhydrous conditions. By substantially anhydrous conditions is meant the complete absence of water or less than 0.1% by weight water in the liquid reaction composition in the carbonylation reactor. At least some of the alcohol and/or reactive derivative thereof will be converted to, and hence present as, corresponding ester in the liquid reaction composition by reaction with carboxylic acid product or solvent. Any suitable concentration of ester in the liquid reaction composition may be used, for example in the range from 0.1 % to 50% by weight, preferably up to about 35% by weight. Thus, for example, in a continuous process for the preparation of acetic acid by carbonylation of methanol and/or a reactive derivative thereof in the presence of water, the concentration of methyl acetate in the liquid reaction composition may typically be up to 5% by weight whilst in a continuous process for the preparation of acetic anhydride by carbonylation of methanol and/or a reactive derivative thereof under substantially anhydrous conditions, the concentration of methyl acetate in the liquid reaction composition may typically be in the range 15 to 30% by weight. It has been found that as water concentration in the liquid reaction composition is decreased it is preferred to increase the ester concentration. Thus for example in a process for preparation of acetic acid at a water concentration of 5.7% by weight the methyl acetate concentration is preferably greater than 1.2% by weight and at a water concentration of 2.5% by weight the methyl acetate concentration is preferably greater than 2% by weight. The rhodium catalyst in the liquid reaction composition may comprise any rhodium containing compound which is soluble in the liquid reaction composition. The rhodium catalyst may be added to the liquid reaction composition in any suitable form which dissolves in the liquid reaction composition or is convertible to a soluble form. Examples of suitable rhodium-containing compounds which may be added to the liquid reaction composition include [Rh(CO)2Cl]2, [Rh(CO)2I]2, [Rh(Cod)Cl]2, rhodium (III) chloride, rhodium (III) chloride trihydrate, rhodium (III) bromide, rhodium (III) iodide, rhodium (III) acetate, rhodium dicarbonylacetylacetonate, RhCl3(PPh3)3 and RhCl(CO)(PPh3)2. Preferably, the rhodium catalyst concentration in the liquid reaction composition is in-the range 50 to 5000 ppm by weight of rhodium, preferably 100 to 1500ppm. The ruthenium and/or osmium promoter may comprise any ruthenium and/or osmium containing compound which is soluble in the liquid reaction composition. The promoter may be added to the liquid reaction composition for the carbonylation reaction in any suitable form which dissolves in the liquid reaction composition or is convertible to soluble form. The promoter compound may be used as chloride free compounds such as acetates which are soluble in one or more of the liquid reaction composition components, for example water and/or acetic acid and so may be added to the reaction as solutions therein. Examples of suitable ruthenium-containing compounds which may be used include ruthenium (III) chloride, ruthenium (III) chloride trihydrate, ruthenium (IV) chloride, ruthenium (III) bromide, ruthenium (III) iodide ruthenium metal, ruthenium oxides, ruthenium (III) formate, [Ru(CO)3l3]~H+, tetra(aceto)chlororuthenium(II,III), ruthenium (III) acetate, ruthenium (III) propionate, ruthenium (III) butyrate, ruthenium pentacarbonyl, trirutheniumdodecacarbonyl and mixed ruthenium halocarbonyls such as dichlorotricarbonylruthenium (II) dimer, dibromotricarbonylruthenium (II) dimer, and other organoruthenium complexes such as tetrachlorobis(4-cymene)diruthenium(II), tetrachlorobis(benzene)diruthenium(II), dichloro(cycloocta-l,5-diene)aithenium (II) polymer and tris(acetylacetonate)ruthenium (III). Examples of suitable osmium containing compounds which may be used include osmium (III) chloride hydrate and anhydrous, osmium metal, osmium tetraoxide, triosmiumdodecacarbonyl, pentachloro-u-nitrododiosmium and mixed osmium halocarbonyls such as tricarbonyldichloroosmium (II) dimer and other organoosmium complexes. In the production of acetic anhydride by carbonylation of methyl acetate with optional methanol in the process of the present invention in batch autoclave experiments, which last for only about 20 minutes, it was found that ruthenium (III) trichloride and osmium (III) trichloride were not suitable sources of promoter unless hydrogen is also present with the carbon monoxide feed gas. Without wishing to be bound by any theory it is believed that, when acetic anhydride is produced using the process of the present invention, the promoter is preferably added to the liquid reaction composition in a low oxidation state form or is converted into a low oxidation state form in situ in the liquid reaction composition. Thus, these precursors may be converted to a suitable form over longer time periods, for example, in a continuous carbonylation process wherein catalyst is continuously recycled between the carbonylation reactor and a product recovery section. The molar ratio of each promoter : rhodium catalyst is suitably in the range 0.1:1 to 20:1, preferably 1:1 to 10:1. It is further preferred, when the process of the present invention is performed with a substantially anhydrous liquid reaction composition that the molar ratio of each promotenrhodium is about 1:1. Preferably, the alkyl halide has an alky! moiety which is the same as the alkyl moiety of the reactant and is more preferably methyl. Preferably, the alkyl halide is an iodide or bromide, most preferably an iodide. Preferably, the concentration of alkyl halide in the liquid reaction composition is in the range 1 to 30% by weight, preferably 1 to 20%, more preferably 5 to 20% by weight. The carbon monoxide reactant may be essentially pure or may contain inert impurities such as carbon dioxide, methane, nitrogen, noble gases, water and C1 to C4 paraffmic hydrocarbons. The presence of hydrogen in the carbon monoxide feed and generated in situ by the water gas shift reaction is preferably kept low, for example, less than 2 bar partial pressure, as its presence may result in the formation of hydrogenation products. Whilst increasing the partial pressure of hydrogen in a carbonylation process performed under substantially anhydrous conditions may increase the rate of reaction, a disadvantage is that it also increases the formation of by-products. An advantage of the present invention is that the presence of a promoter such as ruthenium enables the rate of reaction to be maintained at lower partial pressure of hydrogen than would otherwise be required without the promoter. This has the advantage of reducing byproduct formation whilst maintaining rate of reaction. Thus, for example, the promoters of the present invention may allow the hydrogen partial pressure in a continuous process for the production of acetic anhydride to be reduced from a partial pressure in the range 0.6 to 1 bar to a partial pressure up to 0.5 (suitably 0.05 to 0.5 bar) whilst maintaining rate of reaction and reducing by-product formation. Preferably, the ratio of carbon monoxide to hydrogen is greater than 10:1 molar in the reactor. The partial pressure of carbon monoxide in the reaction is suitably in the range 1 to 70 bar, preferably 1 to 45 bar, more preferably 1 to 3 5 bar. A suitable carbon monoxide partial pressure for production of acetic anhydride is about 20 to 30 bar and a suitable carbon monoxide partial pressure for production of acetic acid in the presence of water is less than 15 bar. The catalyst system of the present invention has been found to be particularly beneficial for the production of carboxylic acid such as acetic acid at relatively low partial pressures of carbon monoxide where the rate of reaction may be limited by the amount of carbon monoxide in solution in the liquid reaction composition. Under these conditions, it has been found that the catalyst system of the present invention has the advantage of providing an increased rate of carbonylation reaction over catalyst systems without the promoters of the present invention. This advantage allows for increased rate of reaction under conditions when the carbon monoxide partial pressure is relatively low, for example less than 5 bar, for example due to a low total pressure in the carbonylation reactor or due to high vapour pressure of components of the liquid reaction composition, for example at high ester concentration in the liquid reaction composition or due to a high concentration of inert gases (for example nitrogen and carbon dioxide) in the carbonylation reactor. The catalyst system may also have advantages of increasing rate of carbonylation when the rate of reaction is reduced by the availability of carbon monoxide in solution in the liquid reaction composition resulting from mass transfer limitations, for example due to poor agitation. A further advantage of the catalyst system of the present invention is that the ruthenium or osmium promoter acts as a stabiliser for the rhodium catalyst at relatively low partial pressures of carbon monoxide for example less than 0.25 bar, for example during recovery of carbonylation product from the reaction composition with the recycle of the catalyst to the carbonylation reaction. Yet a further advantage of the catalyst system of the present invention is the improved carbonylation rate over rhodium alone, which is obtained under low water concentrations in the production of carboxylic acids, for example, at less than 7% by weight water in the reaction composition during the production of acetic acid. The pressure of the carbonylation reaction is suitably in the range 1 to 100 barg, preferably 20 to 50 barg. The temperature of the carbonylation reaction is suitably in the range 130 to 250 °C, preferably in the range 170 to 200 °C. Co-promoters including Group IA metal iodides, quaternary ammonium iodides and phosphonium iodides may be present in the liquid reaction composition. Such co-promoters will reduce the formation of volatile promoter species and so facilitate product recovery and purification. When carboxylic acid, such as acetic acid, is the product of the carbonylation reaction in the presence of a finite concentration of water, the concentration of co-promoter in the liquid reaction composition is preferably equivalent, on a molar basis, to less than about 3% by weight of lithium iodide. When carboxylic anhydride such as acetic anhydride is produced in the carbonylation reaction, the concentration of a co-promoter in the liquid reaction composition is preferably present at up to its limit of solubility, for example up to 30% by weight iodide as N,N dimethyl imidazolium iodide or lithium iodide. Carboxylic acid and/or carbonylation anhydride may be used as a solvent for the reaction. The process of the present invention may be performed as a batch or a continuous process, preferably as a continuous process. Carboxylic acid, ester and/or carboxylic anhydride carbonylation products may be removed from the reactor by withdrawing liquid reaction composition and separating the acid, ester and/or acetic anhydride product by one or more flash and/or fractional distillation stages from the other components of the liquid reaction composition such as rhodium catalyst, ruthenium and/or osmium promoter, alkyl halide, water (if present) and unconsumed reactants which may be recycled to the reactor to maintain their concentrations in the liquid reaction composition. Such separation generally takes place at a carbon monoxide partial pressure less than in the carbonylation reactor. The acid, ester and/or anhydride product may also be removed as a vapour from the reactor. The invention will now be illustrated by way of example only by reference to the following examples and to Figures 1 to 6 in which Figure 1 represents a graph of carbon monoxide uptake against reaction time for Experiment E and Examples 3 and 5; Figure 2 represents a graph of carbon monoxide uptake against reaction time for Example 5 and Experiment H; Figure 3 represents a graph showing the effect of ruthenium promoter on reaction rate against calculated water concentration; and Figure 4 represents a graph of carbon monoxide uptake against reaction time for Experiment K and Example 8; Figures 5 and 6 represent graphs showing the effect of hydrogen concentration in the feedgas on reaction rate for anhydrous carbonylation. In the examples reaction rates are quoted as number of moles of product/reactant produced/consumed per litre of cold degassed reactor composition per hour (mol/l/hr). In the examples the concentration of components and in particular of water and methyl acetate, during the carbonylation reaction was calculated from the starting composition, assuming that one mole of water is consumed for every mole of carbon monoxide that is consumed. No allowance was made for the organic components in the autoclave headspace. A 150 ml Hastelloy B2 (Trade Mark) autoclave equipped with a Magnedrive (Trade Mark) stirrer and liquid injection facility was used for a series of batch carbonylation experiments. A gas supply to the autoclave was provided from a gas ballast vessel, feed gas being provided to maintain the autoclave at a constant pressure and the rate of gas uptake being calculated (with an accuracy believed to be +/-1%) from the rate at which the pressure falls in the gas ballast vessel. At the end of each experiment liquid and gas samples from the autoclave were analysed by gas chromatography. For each batch carbonylation experiment the autoclave was charged with the ruthenium or osmium promoter and the liquid components of the liquid reaction composition excluding part of the acetic acid charge, in which the rhodium catalyst was dissolved. The autoclave was flushed twice with nitrogen and once with carbon monoxide and was then heated with stirring (1000 rpm) to 185 C. After allowing the system to stabilise at autogeneous pressure for about 30 minutes, the rhodium catalyst in acetic acid solution was then injected into the autoclave under pressure of carbon monoxide. The pressure in the autoclave was subsequently maintained at 27 barg with carbon monoxide fed on demand from the gas ballast vessel through the liquid injection facility. After an initial 30 seconds to allow for carbon monoxide to dissolve in the reaction composition, subsequent gas uptake from the ballast vessel was measured every 30 seconds and from this was calculated the rate of carbonylation, expressed as moles of carbon monoxide per litre of liquid reaction composition per hour (mol/l/hr). After uptake of carbon monoxide from the ballast vessel had ceased or the reaction had proceeded for a period of 40 minutes, whichever was sooner, the autoclave was isolated from the gas supply. The contents of the autoclave were cooled to room temperature and the gases were cautiously vented from the autoclave, sampled and analysed. The liquid reaction composition was discharged from the autoclave, sampled and was analysed for liquid products and by-products. To obtain a reliable baseline a number of identical baseline runs may have to be performed to condition the autoclave such that consistent rates are achieved. This conditioning period is often different from autoclave to autoclave and may depend upon its previous history. Experiment A A baseline experiment was performed with the autoclave charged with methyl acetate (244 mmol), water (912 mmol), methyl iodide (101 mmol), and acetic add (703 mmol). The rhodium catalyst solution comprised Rh2(CO)4Cl2 (0.19 mmol) dissolved in acetic acid (83 mmol). The reaction was performed at a constant pressure of 27 barg and at a temperature of 185°C. The rate of reaction, based upon carbon monoxide uptake, remained constant at 8,2 mol/l/hr until a calculated water concentration of 12.1% by weight was reached. At this point the methyl acetate reactant was virtually all consumed. High conversion to acetic acid was observed. Traces of acetaldehyde by-product were detected in the liquid reaction composition at the end of the experiment. The non-condensable gases vented at the end of the experiment were analysed This analysis did not determine hydrogen but included nitrogen and carbon monoxide. The compositions are expressed as a volume percentage of the measureable gases and were found to contain 2.7% carbon dioxide and methane (traces), the balance comprising carbon monoxide. This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. Experiment B Experiment A was repeated. The reaction rate, measured in an identical manner to Experiment A was 8.8 mol/l/hr. The vented gas at the end of the experiment was analysed as in Experiment A and was found to contain 3.4% carbon dioxide and methane (trace). Example 1 Experiment A was repeated except that Rul3 (3.96 mmol) was charged to the autoclave at the start before the rhodium catalyst solution was added. The rate of reaction, based upon carbon monoxide uptake, remained constant at 8.3 mol/l/hr until a calculated water concentration of 11.9% by weight was reached. This rate is, within experimental error, the same as the rates measured in Experiments A and B. This example shows that at the conditions of this example of high water concentrations there is no measurable benefit of the presence of ruthenium in the liquid reaction composition on the carbonylation rate. Subsequent experiments show that as the water concentration is reduced the benefit to a reaction rate becomes measurable. Experiment D A baseline experiment was performed at a lower water concentration than those employed in Examples A and B. The autoclave was charged with methyl acetate (244 mmol), water (556 mmol), methyl iodide (102 mmol), and acetic acid (809 mmol). The rhodium catalyst solution comprised Rh.2(CO)4Cl2 (0.20 mmol) dissolved in acetic acid (83-mmol). The reaction was performed at a constant pressure of 27 barg and at a temperature of185°C The rate of reaction, based upon carbon monoxide uptake, remained constant at 8.06 mol/l/hr, until a calculated water concentration of 6.8% by weight was reached. Acetic acid was the major (>99%) liquid product detected. The measurable, non-condensable gases in the autoclave at room temperature at the end of the reaction were analysed as before and were found to contain by volume, 1.3% carbon dioxide and methane (trace), the balance comprising carbon monoxide. This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. Example 2 Experiment D was repeated except that Rul3 (3.95 mmol) was charged to the autoclave at the start before the rhodium catalyst solution was added. The rate of reaction, based upon carbon monoxide uptake, remained constant at 7.4 mol/l/hr, until a calculated water concentration of 6.0% by weight was reached. The reaction was allowed to proceed to completion and subsequent analysis of the liquid reaction composition revealed acetic acid to be the major (>99%) product. The measurable, non-condensable gases, analysed as before, contained 2.7% carbon dioxide, 0.4% methane and carbon monoxide (balance). This Example is according to the present invention and demonstrates the benefit of the presence of ruthenium in the liquid reaction composition of maintaining the carbonylation rate down to a water concentration of at least as low as 6.0% by weight. Subsequent examples illustrate maintanence of rate to even lower water concentrations. Experiment E A baseline experiment was performed at lower water concentrations than those employed in Experiment D. The autoclave was charged with methyl acetate (244 mmol), water (272 mmol), methyl iodide (101 mmol), and acetic acid (894 mmol). The rhodium catalyst solution comprised Rh2(CO)4Cl2 (0.20 mmol) dissolved in acetic acid (83 mmol). The reaction was performed at a constant pressure of 27 barg and at a temperature of 185°C The rate of reaction, based upon carbon monoxide uptake, did not remain constant but was found to decrease from an initial rate of 6.9 mol/l/hr, until the reaction was stopped after 40 minutes (see Figure 1 which represents carbon monoxide uptake against reaction time). Acetic acid was the major (>99%)observed product. The non-condensable gases measured as before, contained carbon dioxide (trace) and carbon monoxide (balance). This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. Example 3 Experiment E was repeated except that RuCl3.3H2O (0.39 mmol) was charged to the autoclave at the start before the rhodium catalyst solution was added. The rate of reaction, based upon carbon monoxide uptake rate, remained constant at 6.8 mol/l/hr until a calculated water concentration of 2.8% by weight was reached (see Figure 1). The reaction was allowed to proceed to completion and subsequent analysis of the liquid reaction composition showed acetic acid to be the major (>99%) product, although traces of methyl chloride (not quantified) were also detected. The non-condensable gases, measured as before, contained carbon dioxide (trace) and carbon monoxide (balance). This Example is according to the present invention and demonstrates that the presence of ruthenium in the liquid reaction composition allows the reaction rate to remain constant at low water concentrations. Example 4 Example 3 was repeated except that RuCl3.3H2O (1.94 mmol), methyl acetate (244 mmol), water (270 mmol), methyl iodide (102 mmol), and acetic acid (895 mmol) were charged to the autoclave. The rate of reaction, based upon carbon monoxide uptake, remained constant at 8.8 mol/l/hr until a calculated water concentration of 1.7% by weight was reached. The reaction was allowed to proceed until completion and subsequent analysis of the liquid reaction composition showed acetic acid to be the major (>99%) product, although traces of methyl chloride (not quantified) were also detected. The non-condensable gases, measured as before, contained carbon dioxide (trace) and carbon monoxide (balance). This Example is according to the present invention and shows the benefit of an increase in the concentration of ruthenium in the liquid reaction composition on the carbonylation rate by allowing the rate of reaction to remain constant at low water concentrations. Example 5 Example 3 was repeated except that RuCl3.3H2O (3.92 mmol), methyl acetate (244 mmol), water (267 mmol), methyl iodide (102 mmol), and acetic acid (894 mmol) were charged to -the autoclave. The rate of reaction, based upon carbon monoxide uptake, remained constant at 10.4 mol/l/hr until a calculated water concentration of 1.6% by weight was reached (see Figures 1 and 2). The reaction was allowed to proceed to completion and subsequent analysis of the liquid reaction composition showed acetic acid to be the major (>99%) product, although traces of methyl chloride (not quantified) were also detected. The non-condensable gases, measured as before, contained carbon dioxide (trace) and carbon monoxide (balance). This Example is according to the present invention and shows the benefit of a further increase in the concentration of ruthenium in the liquid reaction composition by allowing the rate of reaction to remain constant at low water concentrations. The results of Examples 4, 5 and Experiment E are shown in graph form in Figure 3 as the rate of reaction against calculated water concentration. This shows the benefit of ruthenium of maintaining reaction rate as water concentration decreases during the course of the batch reaction. Similar effects would be expected in continuously operated reactors. Example 6 Experiment E was repeated except that osmium trichloride hydrate (1.69 mmol) was charged to the autoclave at the start before the rhodium catalyst solution was added. The rate of reaction, based upon carbon monoxide uptake, remained constant at 7.3 mol/l/hr until a calculated water concentration of 2.3% by weight was reached. The reaction rate then decreased as the reaction was allowed to proceed to completion. The major (>99%) liquid product was acetic acid although traces of methyl chloride (not quantified) were detected. The non-condensable gases measured as before, contained carbon dioxide (1.1%) and carbon monoxide (balance). This example is according to the present invention and shows the benefit of the presence of osmium in the liquid reaction composition on the reaction rate. Experiment F The autoclave was charged with methyl acetate (244 mmol), water (270 mmol), methyl iodide (101 mmol), acetic acid (978 mmol) and RuCl3.3H2O (3.63 mmol). No rhodium catalyst solution was added to the autoclave. The autoclave was heated at 185 C at a constant pressure of 28 barg for about 1 hour but no uptake of carbon monoxide gas from the ballast vessel was observed. The amount of methyl acetate in the liquid reaction composition at the end of the experiment was measured to be 226 mmol (this may be subject to some degree of calibration error at this high level). The non-condensable gases measured as before, contained carbon dioxide (trace) and carbon monoxide (balance). This is not an example according to the present invention because no rhodium catalyst was present in the liquid reaction composition. This example shows that ruthenium alone did not act as a catalyst for the carbonylation of methyl acetate. Experiment G Experiment F was repeated except that osmium trichloride hydrate (1.69 mmol) rather than ruthenium trichloride trihydrate was charged to the reactor. The amount of methyl acetate in the liquid reaction composition at the end of the experiment was measured to be 233 mmol (this is subject to some degree of calibration error at this high level). The non-condensable gases measured as before, contained carbon dioxide (trace) and carbon monoxide (balance). This is not an example according to the present invention because no rhodium catalyst was present in the liquid reaction composition. This experiment shows that osmium alone did not act as a catalyst for the carbonylation of methyl acetate. Experiment H The autoclave was charged with methyl acetate (244 mmol), water (271 mmol), methyl iodide (101 mmol), acetic acid (894 mmol) and lithium iodide (3.81 mmol). The rhodium catalyst solution comprised Rh2(CO)4Cl2 (0.20 mmol) dissolved in acetic acid (83 mmol). The reaction was performed at a constant pressure of 27 barg and at a temperature of 185°C. The rate of reaction, based upon carbon monoxide uptake, did not remain constant but was found to decrease from an initial rate of 6.8 mol/l/hr, until the reaction was stopped after 40 minutes (see Figure 2). The major (>99%) observed liquid product was acetic acid. The non-condensable gases, measured as before, contained carbon dioxide (trace) and carbon monoxide (balance). This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. This experiment demonstrates that addition of lithium iodide to the liquid reaction mixture does not allow the rate of reaction to remain constant at low water concentrations. Examples at Low Carbon Monoxide Partial Pressure A series of batch carbonylation experiments were performed using the procedure described above except that the autoclave was flushed twice with nitrogen, and was then heated with stirring (1000 rpm) to 185°C, On attaining a temperature of 185°C, nitrogen was introduced into the autoclave to achieve a desired pressure which pressure was less than the final reaction pressure. The gas feed lines to the autoclave were then vented and flushed with carbon monoxide. The pressure in the autoclave was subsequently maintained at a set pressure in the range 27 and 28 barg with carbon monoxide fed on demand from the gas ballast vessel through the liquid injection facility. The partial pressure of carbon monoxide employed in the experiment was then simply calculated by subtracting the pressure when nitrogen was introduced to the autoclave at 185°C from the final reaction pressure. The measurement of gas uptake was as described above. Experiment I A baseline experiment was performed with the autoclave charged with methyl acetate (244 mmol), water (911 mmol), methyl iodide (102 mmol), and acetic acid (706 mmol). The rhodium catalyst solution comprised Rh2(CO)4Cl2 (0.19 mmol) dissolved in acetic acid (83 mmol). The reaction was performed at a constant pressure of 27.5 barg with a partial pressure of carbon monoxide of 6.3 bar, and at a temperature of 185°C. The rate of reaction, based upon carbon monoxide uptake rate, after 5 minutes, was calculated to be 6.4 mol/l/hr. High conversion to acetic acid was observed. Traces of acetaldehyde by-product were detected in the liquid reaction composition at the end of the experiment. The non-condensable gases, measured as before, contained carbon dioxide (3.7%), methane (2.1%) and carbon monoxide (balance). This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition Example 7 Experiment I was repeated except that RuCl3 (3.96 mmol) was charged to the autoclave at the start before the rhodium catalyst solution was added. The reaction pressure was maintained at 27.3 barg, the partial pressure of carbon monoxide being 5.9 bar. The rate of reaction, based upon carbon monoxide uptake rate, after 5 minutes was calculated to be 5.0 mol/l/hr. High conversion to acetic acid was observed. Traces of acetaldehyde by-product were detected in the liquid reaction composition at the end of the experiment. The non-condensable gases, measured as before, contained carbon dioxide (6.4%), methane (6.9%) and carbon monoxide (balance). The difference between the rate measured in this experiment and the rate measured in Experiment I is not considered significant when the slight differences in carbon monoxide partial pressure are also taken into consideration. This example shows that when ruthenium was present in the liquid reaction composition of this experiment at relatively high carbon monoxide partial pressure and relatively high water concentration, there is no measurable benefit on reaction rate. Subsequent experiments show at lower partial pressure of carbon monoxide there is a benefit on reaction rate. Experiment K Experiment I was repeated except that the autoclave was charged with methyl acetate (244 mmol), water (911 mmol), methyl iodide (101 mmol), and acetic acid (704 mmol), and the reaction was performed at 185°C; a total pressure of 27.4 barg and at a carbon monoxide partial pressure of 4.8 bar (0.20 mol of catalyst was used). The rate of reaction, based upon carbon monoxide uptake rate, after 5 minutes was calculated to be 3.6 mol/l/hr (see Figure 4). The reaction ceased after only 104 mmol of carbon monoxide had been fed from the ballast vessel. This corresponded to carbonylation of 43% of the methyl acetate reactant. The major (>99%) product detected in the liquid reaction composition at the end of the experiment was acetic acid. The non-condensable gases, measured as before, contained carbon dioxide (4.3%), methane (9.5%) and carbon monoxide (balance). In contrast to Experiment I and Example 7 evidence of extensive catalyst precipit ation was observed on opening the autoclave. This catalyst precipitation was due to the low partial pressure of carbon monoxide during the experiment. This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. Example 8 Experiment K was repeated except that Rud3.3H20 (3.93 mmol), methyl acetate (244 mmol), water (906 mmol), methyl iodide (101 mmol), and acetic acid (703 mmol) were charged to the autoclave. The reaction was performed at a constant pressure of 27.6 barg, a carbon monoxide partial pressure of 4.7 bar, and at a temperature of 185°C. The rate of reaction, based upon carbon monoxide uptake rate, after 5 minutes was calculated to be 6.4 mol/l/hr (see Figure 4). The reaction continued until all the methyl acetate reactant had been consumed. The major (>99%) product detected in the liquid reaction composition at the end of the experiment was acetic acid. The non-condensable gases, measured as before, contained carbon dioxide (3.7%), methane (2.1%) and carbon monoxide (balance). On opening the autoclave there was no evidence of catalyst precipitation. This example is according to the present invention and shows the benefit of the presence of ruthenium in the liquid reaction composition on the reaction rate at low partial pressures of carbon monoxide. This example also demonstrates that ruthenium stabilises the rhodium catalyst at low partial pressures of carbon monoxide, such as for example as may be present during separation of product and catalyst during product recovery from the reaction composition which takes place at a partial pressure of carbon monoxide less than that in the carbonylation reaction Example 9 Example 8 was repeated except that RuCl3 (3.96 mmol), methyl acetate (244 mmol) water (914 mmol), methyl iodide (101 mmol) and acetic acid (703 mmol) were charged to the autoclave at the start before the rhodium catalyst solution was added. The reaction was undertaken at a constant pressure of 27.5 barg, a carbon monoxide partial pressure of 4.6 bar, and at a temperature of 185 C. The rate of reaction, based upon carbon monoxide uptake rate, after 5 minutes was calculated to be 5.4 mol/l/hr. The reaction was allowed to continue until completion. Subsequent analysis of the liquid reaction composition showed acetic acid (>99%) and acetaldehyde (trace). The non-condensable gases, measured as before, contained carbon dioxide (5.3%), methane (3.1%) and carbon monoxide (balance). There was no evidence of rhodium catalyst precipitation on opening the autoclave. This example is according to the present invention since it demonstrates that addition of ruthenium to the liquid reaction composition at low partial pressures of carbon monoxide both stabilises the rhodium catalyst and promotes the reaction rate. Reactions Under Substantially Anhydrous Conditions Experiment L In the following Experiments and Examples a Hastelloy (Trade Mark)B2 autoclave similar to that used in the previous experiments and examples was used but having a 300 ml volume. The procedure used was also similar. The batch autoclave was flushed with carbon monoxide and then charged with acetic acid (30g, 0.50 moles), acetic anhydride (15g, 0.147 moles), N-methyl imidazole (10.56g, 0.129 moles), methyl acetate (45g, 0.61 moles) and methyl iodide (38.55g, 0.27 moles). The autoclave was pressurised with carbon monoxide to a pressure of 25.4 barg at ambient temperature. The autoclave contents were heated with stirring (1500 rpm) to 185 °C. Once stable at temperature the total pressure in the autoclave was increased to.36 barg by feeding carbon monoxide. Rhodium catalyst [Rh(CO)2Cl]2 (0.2093g, 0.54 mmoles) dissolved in lOg of acetic acid was then introduced using an over pressure of carbon monoxide to give a reaction pressure of 39.8 barg. The reaction was carried out at constant pressure (39.8 barg) with carbon monoxide fed on demand from a ballast vessel to maintain the autoclave pressure, until no further gas uptake was observed. The pressure in the ballast vessel was measured every 12 seconds and a third degree polynominal curve was fitted to this data from which the rate of carbonylation (mol/l/hr) was calculated. The methyl acetate concentration in the reactor was calculated from the carbon monoxide uptake as the reaction progressed. When the methyl acetate concentration was calculated to be 26% by weight the reaction rate was calculated to be 3.5 mol/l/hr.; at 16% by weight calculated methyl acetate concentration the reaction rate was 2.80 mol/l/hr. Methane by product was 0.29 mmol and carbon dioxide by product was 6.93 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 1091 ppm The carbon monoxide had a purity of >99.9%, the impurity being mostly nitrogen. Traces of hydrogen below the limit of analytical detection may have been present. This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. Experiment M Experiment L was repeated except that [Ru(CO)3Cl2]2 (0.283 Ig, 0.55 mmoles) and acetic acid (l.Og, 0.17 mole) were charged to the autoclave at the start prior to flushing the autoclave with carbon monoxide. The autoclave was then charged with acetic acid (39g), acetic anhydride (15g), N-methyl imidazole (10.61g), methyl acetate (45.Ig) and methyl iodide (38.52g). The autoclave was pressurised with carbon monoxide to a pressure of 25.0 barg at ambient temperature. The autoclave contents were heated with stirring (1500 rpm.) to 185 °C. Once stable at temperature the total pressure in the autoclave was increased to 39.8 barg by feeding carbon monoxide. The reaction was carried out at constant pressure (39.8 barg) for a period of 1.5 hours. During this time there was virtually no carbon monoxide gas uptake with a maximum rate of 0.02 mol/l/hr. being observed. This is not an example according to the present invention because no rhodium catalyst was present in the liquid reaction composition. Example 10 Experiment L was repeated except that [Ru(CO)3Cl2] (0.2837g, 0.55 mmoles) was charged to the autoclave via a charging funnel after flushing the autoclave with carbon monoxide and was washed in with the liquid reaction components, acetic acid (30g) acetic anhydride (15g) N-methyl imidazole (10.59g) methyl acetate (45. Ig) and methyl iodide (38.71g). The autoclave was pressurised with carbon monoxide to a pressure of 25.0 barg at ambient temperature and then heated with stirring (1500 rpm) to 185°C reaction temperature. Once stable at reaction temperature, the total pressure in the autoclave was increased to 35.6 barg by feeding carbon monoxide. The catalyst [Rh(CO)2Cl]2 (0.2100g, 0.54 mmoles) dissolved in lOg of acetic acid was then introduced using an over pressure of carbon monoxide. The reaction pressure, after injection of the rhodium catalyst solution, was maintained at 39.0 barg. The reaction was performed until no further gas uptake was observed. When the methyl acetate concentration was calculated to be 26% by weight the reaction rate was calculated to be 4.91 mol/l/hr.; at 16% by weight methyl acetate concentration the reaction rate was 3.40 mol/l/hr. Liquid gas chromatographic analysis of a sample of the liquid reaction composition showed that 940 ppm by weight ethylene diacetate by-product had been formed during the reaction. Analysis of the gases vented from the autoclave, by gas chromatography, showed that 0.58 mmoles of methane and 4.06 mmol carbon dioxide had been formed during the reaction. This Example is according to the present invention and demonstrates the benefit of the presence of ruthenium in the liquid reaction composition on the carbonylation rate of methyl acetate under substantially anhydrous conditions to produce acetic anhydride. Experiment N Experiment L was repeated except that the autoclave was flushed with hydrogen before being charged with acetic acid (32. Ig), acetic anhydride (15g), N-methyl imidazole (10.57g), methyl acetate (45g) and methyl iodide (38.63g). The reactor was then pressurised with hydrogen to an ambient pressure of 2.0 barg, and then with carbon monoxide to a total pressure of 27 barg and heated to the reaction temperature of 185° C The catalyst [Rh(CO)2Cl]2 (0.2103g) dissolved in lOg of acetic acid was then introduced using a over pressure of carbon monoxide. The reaction was then progressed as in Experiment L but at a pressure of 39.6 barg. When the calculated methyl acetate concentration was 26% by weight the reaction rate was calculated to be 7.62 mol/l/hr; at 16% by weight methyl acetate concentration the reaction rate was 5.35 mol/l/hr. Analysis of a sample of the liquid reaction composition by liquid gas chromatography showed that 4572 ppm by weight ethylene diacetate by-product had been formed during the reaction. Analysis of the gases vented from the autoclave, by gas chromatography, showed that 11.18 mmoles methane and 2.35 carbon dioxide had been formed during the reaction. This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. Experiment P Experiment L was repeated except that the total reaction pressure after injection of the rhodium catalyst solution was maintained at 55 barg. When the calculated methyl acetate concentration was 26% by weight the reaction rate was calculated to be 4.47 mol/l/hr.; at 16% by weight calculated methyl acetate concentration the reaction rate was 2.93 mol/l/hr. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 1032 ppm. This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. Example 11 Example 10 was repeated except the total reaction pressure was maintained at 55 barg. When the methyl acetate concentration was 26% by weight the reaction rate was calculated to be 6.2 mol/l/hr.; at 16% by weight methyl acetate concentration the reaction rate was 4.28 mol/l/hr. Analysis of the final reaction composition showed 665 ppm ethylidene diacetate by-product to be present This Example is according to the present invention and a comparison with Experiment P demonstrates the benefit of the presence of ruthenium in the liquid reaction composition on carbonylation rates under substantially anhydrous conditions at higher total reaction pressure. Example 12 Example 10 was repeated except that [Ru(CO)3Cl2]2 (2.83g, 5.53 mmoles) and acetic acid (2.09 g) were added to the autoclave prior to flushing with carbon monoxide. The autoclave was then charged with acetic acid (23.6g), acetic anhydride (15g), N-methyl imidazole (10.59g), methyl acetate (45g) and methyl iodide (41.34g). The autoclave was pressurised to 25 barg at ambient temperature with stirring (1500 rpm) and then heated to reaction temperature of 185°C. Once stable at reaction temperature, the total pressure in the autoclave was increased to 35.9 barg by feeding carbon monoxide. The reaction pressure, after injection of the rhodium catalyst solution ([Rh(CO)2Cl]2 (0.2095g in lOg acetic acid), was maintained at 39.2 barg. When the calculated methyl acetate concentration was 26% by weight the reaction rate was calculated to be 6.23 mol/l/hr.; at 16% by weight calculated methyl acetate concentration the reaction rate was 4.12 mol/l/hr. Carbon dioxide by product was 3.49 mmol and methane by-product was 0.58 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 810 ppm. This Example is according to the present invention and demonstrates the benefit of the presence of ruthenium in the liquid reaction composition on carbonylation rates under substantially anhydrous conditions. Example 13 Example 10 was repeated except that hydrogen was used to flush the autoclave after it had been charged with [Ru(CO)3Cl2]2 (0.2833g) and acetic acid (Ig, 0.017 mole). The autoclave was then charged with acetic acid (30g), acetic anhydride(15g), N-methyl imidazole (10.60g), methyl acetate (45.2g) and methyl iodide (38.39g). Hydrogen was used to pressurise the autoclave to a pressure of 2.0 barg at ambient temperature, and then the autoclave was pressurised with carbon monoxide to a total pressure of 25.1 barg. The autoclave was heated to 185°C with stirring (1500 ppm). Once stable at temperature the total pressure was increased to 35.3 barg by feeding carbon monoxide. The catalyst was injected and the reaction pressure, after injection of the rhodium catalyst solution, ([Rh(CO)2Cl]2 0.2105g in lOg of acetic acid) was maintained at 39.6 barg. When the calculated methyl acetate concentration was 26% by weight the reaction rate was calculated to be 8.64 mol/l/hr.; at 16% by weight calculated methyl acetate concentration the reaction rate was 5.76 mol/l/hr. Carbon dioxide by-product was 4.09 mmol and methane by-produce was 11.11 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 7739 ppm. This Example is according to the present invention and demonstrates the benefit of the presence of ruthenium in the liquid reaction composition on carbonylation rates under substantially anhydrous conditions and in the presence of carbon monoxide and hydrogen in a molar ratio of carbon monoxide : hydrogen of greater than 10:1. Example 14 Example.10 was repeated except that [Ru3(CO)12] (0.2306g,) and acetic acid (1.04g) were added to the autoclave prior to flushing with carbon monoxide. The autoclave was then charged with acetic acid (29g), acetic anhydride (15g), 1 N-methyl imidazole (10.56g), methyl acetate (45g) and methyl iodide (38.59g). The reactor was then pressurised with carbon monoxide to a pressure of 25.3 barg at ambient temperature and heated to 185°C with stirring (1500 ppm). Once stable at temperature the total pressure in the autoclave was increased to 35.8 barg by feeding carbon monoxide. The reaction pressure, after injection of the rhodium catalyst solution [(Rh(CO)2Cl]2 (0.2098g) in lOg of acetic acid), was maintained at 39.6 barg. When the calculated methyl acetate concentration was 26% by weight the reaction rate was calculated to be 5.47 mol/l/hr.; at 16% by weight calculated methyl acetate concentration the reaction rate was 3.70 mol/l/hr. Carbon dioxide by-product was 3.47 mmol and methane by-product was 1.16 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 1331 ppm. This Example is according to the present invention and demonstrates the benefit of the presence of ruthenium in the liquid reaction composition on the carbonylation rates under substantially anhydrous conditions. Example 15 Example 10 was repeated except that [Os3(CO)i2] (0.2973g, 0.33 mmoles) and acetic acid (1.08g 0.017 mole) were added to the autoclave prior to flushing with carbon monoxide. The autoclave was then charged with acetic acid (29g), acetic anhydride (15g), 1 N-methyl imidazole (10.54g), methyl acetate (45g) and methyl iodide (38.59g). The reactor was then pressurised with carbon monoxide to a pressure of 25.1 barg at ambient temperature and heated to 185°C with stirring (1500 ppm). Once stable at temperature the total pressure was increased to 35.7 barg by feeding carbon monoxide . The reaction pressure, after injection of the rhodium catalyst solution ([Rh(CO)2Cl]2, 0.2100g in lOg of acetic acid), was maintained 39.5 barg. When the calculated methyl acetate concentration was 26% by weight the reaction rate was calculated to be 6.86 mol/l/hr.; at 16% by weight calculated methyl acetate concentration the reaction rate was 4.27 mol/l/hr. Carbon dioxide by-product was 3.41 mmol and methane by-product was 0.57 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 1010 ppm. This Example is according to the present invention and demonstrates the benefit of the presence of osmium in the liquid reaction composition on carbonylation rates under substantially anhydrous conditions, Example 16 Example 10 was repeated except that [Os3(CO)12] (1.6267g) and acetic acid (1.03g) were added to the autoclave prior to flushing with carbon monoxide. The autoclave was charged with acetic acid (26.2g), acetic anhydride (15g), 1 N-methyl imidazole (10.58g), methyl acetate (45. Ig) and methyl iodide (39.86g). The autoclave was then pressurised with carbon monoxide to a pressure of 25.9 barg at ambient temperature and heated to 185°C with stirring (1500 ppm). Once stable at temperature the total pressure was increased to 367 barg by feeding carbon monoxide. The reaction pressure, after injection of the rhodium catalyst solution ([Rh(CO)2Cl]2 0.2108g in lOg of acetic acid), was maintained at 40.7 barg. When the calculated methyl acetate concentration was 26% by weight the reaction rate was calculated to be 7.29 mol/l/hr; at 16% by weight calculated methyl acetate concentration the reaction rate was 4.02 mol/l/hr. Analysis of the liquid reaction composition at the end of the reaction by glc showed 1370 ppm by weight ethylene diacetate by-product to be present. Analysis of the gases vented from the autoclave by gas chromatography showed that 2.93 moles of each of carbon dioxide and methane had formed in the reaction. This Example is according to the present invention and demonstrates the benefit of the presence of osmium in the liquid reaction composition on carbonylation rates under substantially anhydrous conditions This Example also shows that the use of osmium promoter enables a reaction rate comparable to that of Experiment N but without the use of hydrogen and therefore with lower amounts of by-product ethylidene diacetate and methane being formed. Example 17 Example 10 was repeated except that RuCl3.3H2O (0.291g, 1.1 mmoles) and acetic acid (Ig) was added to the autoclave prior to flushing with carbon monoxide and then charging with the following components: acetic acid 29.Og acetic anhydride 15g 1-N methyl imidazole 10.62g methyl acetate 45.38g methyl iodide 38.42g The autoclave was then pressurised with carbon monoxide to 25.4 barg at ambient temperature and heated to 185°C with stirring (1500 ppm). Once stable at temperature the total pressure was increased to 36 barg with carbon monoxide before the catalyst [(Rh(CO)2Cl]2 0.2106g in lOg of acetic acid) was injected with an over pressure of carbon monoxide. The reaction was progressed at a constant pressure of 39.9 barg until no further carbon monoxide was taken up. At a calculated methyl acetate concentration of 26% by weight the reaction rate was calculated to be 2.39 mol/l/hr and at 16% calculated methyl acetate the reaction rate was calculated to be 1.81 mol/l/hr. Carbon dioxide by-product was 2.89 mmol and methane by-product was 0.0 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 606 ppm. Example 18 Example 17 was repeated using similar amounts of reagents: RuCl33H2O (in Ig acetic acid) 0.2850g acetic acid (main charge) 29g acetic anhydride 15g 1 N-methyl imidazole 10.62g methyl acetate 45. Ig methyl iodide 38.52g [Rh(CO)2Cl]2 (in IOg acetic acid) 0.2104g In this Example however, the autoclave was flushed with hydrogen after it had been charged with the RuCl3.3H2O and was initially pressurised with hydrogen to 2.2 barg at ambient temperature and then to a total pressure of 25 barg with carbon monoxide before heating. The reaction was performed at a total pressure of 39.0 barg until no further uptake of carbon monoxide was observed. At a calculated methyl acetate concentration of 25% by weight the rate of reaction was 8.51 mol/l/hr and at 16% methyl acetate the rate was 5.83 mol/l/hr. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 6407 ppm. This Example demonstrates the use of hydrogen in combination with RuCl33H2O. Example 19 Example 18 was repeated using Os3(CO)12 (0.3263, 0.36 mmoles) in place of RuCl33H2O and the following amounts of reagents and conditions, acetic acid with 053(CO) 12 1-Hg acetic acid (main charge) 29g acetic anhydride !5.21g 1-N-methyl imidazole 10.65g methyl acetate 45g methyl iodide 38.56g [Rh(CO)2Cl]2 (in lOg acetic acid) 0.2 Ig Initial pressurisation (hydrogen) - 2.1barg Further pressurisation at ambient temperature with carbon monoxide (total pressure) - 25,3 barg Pressure before injection of rhodium catalyst - 35.9 barg Constant reaction pressure - 40.3 barg At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 8.30 mol/l/hr and at 16% methyl acetate was 5.54 mol/l/hr. Carbon dioxide by-product was 2.33 mmol and methane by-product was 6.40 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 10992 ppm. Experiment R Example 18 was repeated without any ruthenium compound or imidazole co- promoter. The autoclave was flushed with hydrogen prior to charging: acetic acid 59g acetic anhydride 15g methyl acetate 44.98g methyl iodide 20.45g The autoclave was pressurised with hydrogen to 2.0 barg at ambient temperature and then to a total pressure of 40 barg with carbon monoxide before heating to 185°C with stirring (185°C) Once stable at temperature catalyst ([Rh(CO)2Cl]2 0.2119g in lOg of acetic acid) was injected and the reaction progressed at a constant pressure of 54 barg until no further uptake of carbon monoxide was observed. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 2.70 mol/l/hr and at 16% calculated methyl acetate was 1.34 mol/l/hr. Example 20 Experiment R was repeated except that [Ru(CO)3Cl2]2 °-285g, 0.55 mmoles was charged to the autoclave prior to flushing with hydrogen. After changing the other components, the initial pressurisation with hydrogen was to 1 barg and with carbon monoxide to a total pressure of 43 barg at ambient temperature The catalyst ([Rh(CO)2Cl]2 0.213g in lOg of acetic acid) was introduced and the reaction progressed at a constant pressure of 55 barg until no further carbon monoxide was taken up. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 3.37 mol/l/hr and at 16% by weight was 1.98 mol/l/hr. This Example shows the benefits of ruthenium over Experiment R. Experiment S This experiment uses an alkali metal iodide, lithium iodide as carbonylation co-promoter. Experiment L was repeated except that initially Lil (17.14g, 0.128 mole) was placed in the base of the autoclave under a nitrogen atmosphere and acetic acid (20.01g, 0.33 mole) was added whilst maintaining the nitrogen cover. The autoclave was then reassembled and flushed with nitrogen and then with carbon monoxide before the following reagents were charged. acetic acid 21.34g acetic anhydride 15.06g methyl acetate 45.1g methyl iodide 20.43g The autoclave was then pressurised with carbon monoxide to 25.9 barg at ambient temperature before being heated to 185°C with stirring (1500 ppm). Once stable temperature had been achieved the total pressure was increased to 36.3 barg by feeding carbon monoxide from the ballast vessel and then the catalyst ([Rh(CO)2Cl]2 0.2104g in lOg of acetic acid) was introduced using an overpressure of carbon monoxide. The reaction progressed at a constant pressure of 40.0 barg until no further carbon monoxide was taken up. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 8.81 mol/l/hr and at 16% the rate was 5.66 mol/l/hr. Carbon dioxide by product was 1.72 mmol and methane by-product was 0.57 mrnol. Analysis of the liquid reaction composition at the end showed 554 ppm ethylidene diacetate. This is not an example according to the present invention because no ruthenium or osmium promoter were used. Example 21 Experiment S was repeated except that Ru3(CO)]2 (0.2303g, 0.36 mmol) was added initially with the lithium iodide (17. lOg) and acetic acid (21 g). Similar amounts of reagents and conditions were used: acetic acid 20g acetic anhydride 15.04g methyl acetate 45.33g methyl iodide 20.35g [(Rh(CO)2Cl]2 in lOg of acetic acid 0.2094g initial pressurisation with carbon monoxide - 25.9 barg subsequent pressurisation with carbon monoxide - 35.9 barg constant pressure during reaction - 40.0 barg At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 10.06 mol/l/hr and at 16% was 5.27 mol/l/hr. Carbon dioxide by-product was 2.30 mmol and methane by-product was 2.30 mmol. Analysis of the liquid reaction composition at the end showed 423 ppm ethylidene diacetate. This is an Example according to the present invention and shows the benefit of ruthenium with lithium iodide co-promoter for acetic anhydride production. Example 22 Experiment S was repeated except that Os3(CO)]2 (0-3264g, 0.36 mmoles) was initially added with the Lil (17.17g, 0.128 mole) and acetic acid (20g). Similar amounts of reagents and conditions were used: acetic acid 20g acetic anhydride i5.03g methyl acetate 4 5.13 g methyl iodide 20.32g [Rh(CO)2Cl]2, (in lOg of acetic acid) 0.2098g Initial pressurisation with carbon monoxide - 26.0 barg Subsequent pressurisation - 36.2 barg Constant pressure during reaction - 40.7 barg At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 10.70 mol/l/hr and at 16% was 6.10 mol/l/hr. Carbon dioxide by-product was 2.31 mmol and methane by-product was 1.73 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 757 ppm. This is an example according to the present invention and shows the benefit of osmium with lithium iodide co-promoter for acetic anhydride production. Experiment T Experiment S was repeated except that hydrogen was used to flush the autoclave after flushing with nitrogen and the reagents charged were: Lil ) 17.18g with acetic acid ) 21g additional acetic acid 20.Og acetic anhydride 15.02g methyl acetate 45g methyl iodide 20.29g The autoclave was pressurised with hydrogen to 2.2 barg then with carbon monoxide to a total pressure of 25.9 barg at ambient temperature before heating to 185°C with stirring (1500 ppm). Once stable temperatures have been achieved the pressure was increased to 35.7 barg by feeding carbon monoxide. Then the catalyst ([Rh(CO)2Cl]2i 0.2104g) in lOg of acetic acid) was injected and the reaction progressed at a constant total pressure of 40.6 barg until no further carbon monoxide was taken up. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 10.43 mol/l/hr and at 16% was 7.01 mol/l/hr. Carbon dioxide by-product was 2.42 mmol and methane by-product was 14.54 mmol. Analysis of the final reaction composition showed ethyledene diacetate by-product present at 4601 ppm. Example 23 Experiment T was repeated using the following amounts of reagents and conditions: initial charge [Ru(CO)3Cl2]2 0.2823g (0.55 mmol) Lil 17.25g acetic acid (initial charge) 20g main charge acetic acid 20g acetic anhydride 15.03g methyl acetate 45.45g methyl iodide 20.19g catalyst [(Rh(CO)2Cl]2 in lOg of acetic acid) 0.2107g pressures initial pressurisation with hydrogen 2.2 barg subsequent pressurisation with carbon monoxide to total pressure 25.0 barg pressure increased at 185°C to 35.0 barg constant reaction pressure 397 barg At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 11.67 mol/l/hr and at 16% was 7.87 mol/l/hr. Carbon dioxide by-product was 1.72 mmol and methane by-product was 13.79 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 5644 ppm. This is an example according to the present invention and shows the benefits of using ruthenium with lithium iodide copromoter and in the presence of carbon monoxide and hydrogen at a ratio of carbon monoxide: hydrogen of greater than 10:1 to produce acetic anhydride. Experiment U Repeats of Experiment S consistently resulted in carbonylation rates significantly lower than those reported above. The higher rate achieved in Experiment S may be due to osmium contamination from the prior experiment. In attempting to repeat the experiment problems were experienced with aerial oxidation of the Lil charged to the autoclave prior to reaction. Therefore the following alternative procedure was used: Experiment L was repeated except that lithium acetate dihydrate (13.10g, 0.128 mole) was placed in the bottom of the autoclave under a nitrogen atmosphere and acetic acid (l.Slg, 0.03 mole) was added while maintaining the nitrogen cover. The actoclave was then assembled, placed in position and flushed with nitrogen. The autoclave was then flushed with carbon monoxide and charged with acetic acid (9.55g, 0.16 mole), acetic anhydride (41.33g, 0.40 moles), methyl acetate (35.66g, 0.48 moles) and methyl iodide (39.04g, 0.275 moles). The autoclave was then pressurised with carbon monoxide to an ambient pressure of 25.4 barg. The reactor contents were stirred (1500 r.p.m.) and heated to 185°C. Once stable at temperature the total pressure was increased to 36.2 barg by feeding carbon monoxide from the ballast vessel. The catalyst [Rh(CO)2Cl]2(0.2109g, 0.54 mmoles) dissolved in lOg of acetic acid was introduced using an overpressure of carbon monoxide to give a reaction pressure of 41.1 barg. The reaction was carried out at constant pressure (41. Ibarg) until no further gas uptake was observed. The methyl acetate concentration in the reactor was calculated from the carbon monoxide uptake as the reaction progressed. When the methyl acetate concentration was 26% by weight the reaction rate was calculated to be 3.77 mol/l/hr; at 16% w/w methyl acetate the reaction rate was 2.53 mol/ltr/hr. Carbon dioxide by-product was 2.34 mmol and methane by-product was 0.59 mmol. Analysis of the liquid reaction composition at the end showed 346 ppm ethylidene diacetate. Experiment V Experiment L was repeated except that the autoclave was flushed three times with carbon monoxide and then once with a mixture of ca. 0.25% hydrogen in carbon monoxide. The carbon monoxide/hydrogen gas mixture was used to pressurise the reactor, to inject the catalyst and as feed from the ballast vessel. The following components were charged to the autoclave: Acetic acid 29.82g Acetic anhydride 15.01g Methyl acetate 45. lOg Methyl iodide 38 53g 1-N-methyl imidazole 10.56g [Rh(CO2)Cl]2 in 1 Og acetic acid 0.211 Og The autoclave was then pressurised with a mixture of hydrogen and carbon monoxide (0.248% H2) to 25.1 barg. Once stable at temperature the total pressure was increased to 35.1 barg. The reaction was progressed at a constant pressure of 40.0 barg. At a calculated methyl acetate concentration of 26% by weight the reaction rate was calculated to be 7.65 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 5.43 mol/l/hr. Carbon dioxide by- product was 4.47 mmol and methane by-product was 1.12 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 2016 ppm. Example 24 Experiment V was repeated except that 0.2308g of Ru3(CO)12 and Ig of acetic acid were added to the autoclave as an initial charge before flushing. The following components were subsequently charged to the autoclave: Acetic acid 29.13g Acetic anhydride 15.02g Methyl acetate 45.00g Methyl iodide 38.69g 1-N-methyl imidazole 10.51g [Rh(CO2)Cl]2 in lOg acetic acid 0.2096g At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 8.45 mol/l/hr, and at 16% by weight calculated methyl acetate the reaction rate was calculated to be 5.88 mol/l/hr. Carbon dioxide byproduct was 1.75 mmol and methane by-product was 1.17 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 1529 ppm. This is an example according to the present invention and shows the benefit of ruthenium in the liquid reaction composition on carbonylation rate and concentration of by-products in the presence of 1 N-methyl imidazole promoter and under substantially anhydrous conditions Experiment W Experiment V was repeated except that a mixture of ca. 0.1% hydrogen in carbon monoxide was used. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 6.25 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 4.34 mol/l/hr. Carbon dioxide by-product was 3.47 mmol and methane by-product was 0.58 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate byproduct to be 1102 pprn. Example 25 Experiment W was repeated except that 0.2308g of Ru3(CO)12 and 1. lOg of acetic acid were added to the autoclave as an initial charge before flushing. The following components were subsequently charged to the autoclave: Acetic acid 28.95g Acetic anhydride IS.Olg Methyl acetate 45.23g Methyl iodide 38.53g 1-N-methyl imidazole 10.45g [Rh(CO2)Cl]2 in lOg acetic acid 0.2103g At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 7.46 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 5.13 rnol/1/hr. Carbon dioxide by-product was 3.88 mmol and methane by-product was 1.66 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate byproduct to be 1420 ppm. This is an example according to the present invention and shows the benefit of ruthenium in the liquid reaction composition on carbonylation rate and concentration of by-products in the presence of 1 N-methyl imidazole promoter under substantially anhydrous conditions. Experiment X Experiment V was repeated except that a mixture of ca. 0.05% hydrogen in carbon monoxide was used. The following components were charged to the autoclave: Acetic acid 29.72g Acetic anhydride 15.00g Methyl acetate 45.1 Og Methyl iodide 38.72g 1-N-methyl imidazole 10.56g [Rh(CO2)Cl]2 in lOg acetic acid 0.2098g The reaction pressure was 39.4 barg. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 5.67 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 3.99 mol/l/hr. Carbon dioxide by-product was 4.00 mmol and methane by-product was 0.29 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate byproduct to be 914 ppm. Example 26 Experiment X was repeated except that 0.2304g of Ru3(CO)12 and I-04g of acetic acid were added to the autoclave as an initial charge before flushing and the amount of acetic acid subsequently charged to the autoclave was 29g. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 7.45 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 5.12 mol/l/hr. Carbon dioxide by-product was 3.46 mmol and methane by-product was 0.29 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate byproduct to be 1181 ppm. This is an example according to the present invention and shows the benefit of ruthenium in the liquid reaction composition on carbonylation rate and concentration of by-products in the presence of 1 N-methyl imidazole promoter and under substantially anhydrous conditions. Experiment Y Experiment T was repeated using the following amounts of reagents and conditions: initial charge Lil 17.21g acetic acid 20.0Ig main charge acetic acid 20.06g acetic anhydride 15.05g methyl acetate 45.13g Methyl iodide 20.35g catalyst [Rh(CO2C1]2 in lOg acetic acid 0.2101g pressures initial pressurisation with hydrogen 0.09 bara subsequent pressurisation with carbon monoxide 25.1 barg pressure increased at I85°C to 35.8 barg constant reaction pressure 40.2 barg At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 9.52 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 6.39 mol/l/hr. Carbon dioxide by-product was 1.16 mrnol and methane by-product was 11.06 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 475 ppm. Example 27 Experiment Y was repeated except that [Ru(CO)3Cl2]2 (0.284Ig) was included in the initial charge. The autoclave was initially pressurised with hydrogen to 0.09 bara, was subsequently pressurised with carbon monoxide to 24.2 barg, the pressure was increased at 185°C to 35.3 barg and the reaction was carried out at a constant pressure of 39.6 barg At a calculated methyl acetate concentration of 26% by weight the rate of reaction was 10.79 mol/l/hr, and at a calculated methyl acetate concentration of 16% by weight the reaction rate was calculated to be 7.09 mol/l/hr. Carbon dioxide byproduct was 1.13 mmol and methane by-product was 1.70 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 700 ppm. This Example is according to the present invention and demonstrates the benefit of ruthenium in the liquid reaction composition on carbonylation rate and concentration of by-products in the presence of Lil promoter under substantially anhydrous conditions. Experiment Z Experiment U was repeated except that the autoclave was flushed three times with carbon monoxide and then once with a mixture of ca. 0.1% hydrogen in carbon monoxide. This mixture was then used instead of pure carbon monoxide to pressurise the autoclave, introduce the catalyst, and as feed from the ballast vessel. Nitrogen cover was not rigorously used when charging the initial charge. Reagents and conditions were as follows. initial charge lithium acetate dihydrate 13.23g acetic acid 11.02g main charge acetic anhydride 41,29g methyl acetate 35.79g methyl iodide 38.96g catalyst [Rh(CO2Cl]2 in lOg acetic acid 0.2096g pressures Initial pressurisation with 0.11% H2/CO 25.3 barg Subsequent pressurisation with 0.11% H2/CO 35.1 barg Constant pressure during reaction 40.1 barg At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 5.93 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 4.97 mol/l/hr. Carbon dioxide by-product was 2.88 mmol and methane by-product was 1.15 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate byproduct to be 495 ppm. Example 28 Experiment Z was repeated except that 0.2306g of Ru3(CO)j2 was added to the initial charge, and the reaction pressure was 39.5 barg. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 9.36 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 6.51 mol/l/hr. Carbon dioxide by-product was 2.28 mmol and methane by-product was 1.71 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate byproduct to be 740 ppm This Example is according to the present invention and demonstrates the benefit of ruthenium in the liquid reaction composition on carbonylation rate and concentration of by-products under substantially anhydrous conditions when lithium acetate is added to the reaction composition. Experiment AA Experiment Z was repeated except that a mixture of ca. 0.25% hydrogen in carbon monoxide was used At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 7.84 mol/l/hr, and at 16% calculated methyl acetate concentration was calculated to be 6.14 mol/l/hr. Carbon dioxide by-product was 1.15 mmol and methane by-product was 1.15 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 681 ppm. Example 29 Experiment AA was repeated except that 0.2308g of Rii3(CO) 12 was added to the initial charge. Similar reagent quantities and conditions were used. At a calculated methyl acetate concentration of 26% by weight the rate of reaction was calculated to be 9.95 mol/l/hr, and at 16% calculated methyl acetate concentration the reaction rate was calculated to be 6.88 mol/l/hr. Carbon dioxide by- product was 2.24 mmol and methane by-product was 2.24 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 1227 ppm. Example 30 Experiment U was repeated with the following components being charged to the autoclave. initial charge Ru3(CO)12 0.2313g Lithium acetate dihydrate 13.14g Acetic acid 11.02g main charge Acetic anhydride 41.41g Methyl acetate 35.72g Methyl iodide 38.98g catalyst [Rh(CO)2Cl]2 in lOg acetic acid 0.2095g pressures Initial pressurisation with carbon monoxide 25.3 barg subsequent pressurisation to 36.0 barg Constant pressure during reaction 39.9 barg At a calculated methyl acetate concentration of 25% by weight the rate of the reaction was calculated to be 9.72 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was calculated to be 5.13 mol/l/hr. Carbon dioxide by-product was 2.26 mmol, and methane by-product was 2.26 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate byproduct to be 459 ppm Example 31 Experiment U was repeated with the following components being charged to the autoclave: initial charge Ru3(CO)12 230g Lithium acetate dihydrate 13.13g Acetic acid 6.10g main charge Acetic anhydride 41.54g Methyl acetate 3 5.71 g Methyl iodide 41.75g catalyst [Rh(CO)2ClJ2 in lOg acetic acid 0.2I05g pressures Initial pressurisation with carbon monoxide 25.0 barg subsequent pressurisation to 36.0 barg Constant pressure during reaction 39.2 barg At a calculated methyl acetate concentration of 25% by weight the rate of the reaction was 11.03 mol/l/hr, and at 16% by weight calculated methyl acetate concentration the reaction rate was 6.51 mol/l/hr. Carbon dioxide by-product was 2.21 mmol, and methane by-product was 10.50 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 1750 ppm. Example 32 Example 30 was repeated except that hydrogen was used to purge the autoclave and the pressures were as follows: Initial pressurisation with hydrogen 2.2 barg Further pressurisation with carbon monoxide to 25.1 barg Subsequent pressurisation before catalyst injection 35.6 barg Constant pressure during reaction 39.7 barg At a calculated methyl acetate concentration of 25% by weight the rate of the reaction was 12.62 mol/l/hr, and at 16% by weight calculated methyl acetate concentration was calculated to be 8.70 mol/l/hr. Carbon dioxide by-product was 2.84 mmol, and methane by-product was 21.59 mmol. Analysis of the final reaction composition showed the concentration of ethylidene diacetate by-product to be 7542 ppm. Examples 3 1 and 32 show that ruthenium at a molar ratio to rhodium of 10:1 with a lithium iodide co-promoter increases reaction rate compared to that at a molar ratio of 1:1 but that there is an increase in by-product make. The corresponding increase in by-product make with 10:1 Ru:Rh with N,N dimethyl imidazolium iodide was less than with lithium iodide co-promoter. Data from the preceding experiments and examples for carbonylation reactions under anhydrous conditions are plotted in graph form in Figures 5 and 6 which show respectively the effect of ruthenium on the rate of a rhodium catalysed anhydrous carbonylation process with lithium iodide and N N dimethyl imidazolium iodide co-promoters. The data shown at 9.5% hydrogen was obtained by feeding 2 bar hydrogen to the autoclave and pure carbon monoxide from the ballast vessel, the hydrogen concentration being an estimate. In other cases a hydrogen/carbon monoxide feed gas was used. Figures 5 and 6 show that ruthenium promotes the reaction rate over that of rhodium alone for both lithium iodide and N N dimethyl imidazolium iodide co-promoted anhydrous carbonylation at various hydrogen concentrations. The results also show that with the ruthenium promoter the reaction rate is maintained as hydrogen concentration is decreased so that the process may be operated with a lower hydrogen partial pressure and hence lower by-product formation This effect is more pronounced for lithium iodide co-promoter than for N N dimethyl imidozalium iodide co-promoter. Stability Tests A 150ml Hastelloy B2 (Trade Mark) autoclave equipped with a Magnedrive (Trade Mark) stirrer and liquid injection facility was used to prepare solutions for the following stability tests. For each stability test the autoclave was charged with rhodium catalyst, ruthenium or osmium promoter arid the liquid components of the liquid reaction composition excluding methyl acetate. The autoclave was flushed twice with nitrogen and once with carbon monoxide, and was then heated with stirring (1000 rpm) to 185°C under a carbon monoxide pressure of 3 barg. After allowing the system to reach 185°C, carbon monoxide was introduced into the autoclave and the pressure was subsequently maintained at 27 barg with carbon monoxide for 30 minutes The autoclave was then isolated from the gas supply and subsequently cooled to room temperature. The gases were cautiously vented from the autoclave and the liquid reaction composition was discharged. Methyl acetate was then added to the liquid reaction composition. The liquid reaction composition was then analysed by gas chromatography and methyl iodide was added to the composition to restore the methyl iodide concentration to 2% w/w. A small volume (25 ml) of the composition was then placed in a glass pressure vessel, and heated to 130°C, under a nitrogen pressure of 2 barg. A sample of this heated solution was subsequently removed from the glass pressure vessel, centrifuged and analysed for rhodium by atomic absorption spectroscopy. The remaining solutio.n was maintained at 130°C for 23 hours, after which a further sample was taken and analysed for rhodium. Experiment BB A baseline experiment was performed with the autoclave charged with water (611 mmol), methyl iodide (14 mmol), acetic acid (1396 mmol) and rhodium carbonyl chloride dimer (0.296 mmol). After discharging the autoclave methyl acetate (11 mmol) and methyl iodide (10 mmol) were added to the liquid reaction composition. The initial concentration of rhodium in solution was found to be 625 ppm. After being heated at 130°C for 23 hours the rhodium concentration in solution had decreased to 58 ppm. This represented a precipitation of 90.7% of the rhodium from the composition. This is not an example according to the present invention because no ruthenium or osmium promoter was present in the liquid reaction composition. Example 33 Experiment BB was repeated except that the autoclave was also charged with 20 molar equivalents of ruthenium trichloride hydrate per rhodium carbonyl chloride dimer. The initial concentration of rhodium in the liquid composition was found to be 608 ppm, whereas after 23 hours the concentration had decreased to 270 ppm. This represented a precipitation of 55.6% of the rhodium from the solution. This is an example according to the present invention as it demonstrates that addition of ruthenium enhances rhodium stability at low carbon monoxide partial pressures, for example, during the product recovery stage of the process. WE CLAIM : 1. A process for the carbonylation of a C1 to C4 alkyl alcohol and/or a reactive derivative thereof which process comprises contacting a C1 to C4 alkyl alcohol and/or a reactive derivative thereof with carbon monoxide at a temperature in the range 130 to 250°C and a pressure in the range 1 to 100 barg in a liquid reaction composition in a carbonylation reactor, the liquid reaction composition comprises: (a) a rhodium catalyst, (b) an alkyl halide, and (c) as promoter, at least one of ruthenium and osmium. 2. A process as claimed in claim 1 in which the liquid reaction composition additionally comprises the ester of the alcohol and/or reactive derivative thereof and the carboxylic acid product at a concentration in the range 0.1 to 50% by weight. 3. A process as claimed in claim 2 in which the liquid reaction composition additionally comprises water at a concentration in the range 0.1 to 15% by weight. 4. A process as claimed in claim 3 in which the ester concentration is up to 5% by weight. 5. A process as claimed in claim 3 or claim 4 in which the water concentration is less than 7% by weight. 6. A process as claimed in claim 5 in which the ester concentration is greater than 1.2% by weight. 7. A process as claimed in any one of claims 3 to 6 in which the partial pressure of carbon monoxide in the reactor is less than 15 bar. 8. A process as claimed in claim 7 in which the partial pressure of carbon monoxide in the reactor is less than 5 bar. 9. A process as claimed in claim 2 in which there is maintained in the liquid reaction composition either a complete absence of water or less than 0.1% by weight water. 10. A process as claimed in claim 9 in which the liquid reaction composition additionally comprises a co-promoter selected from the group consisting of Group LA metal iodides, quaternary ammonium iodides and phosphonium iodides at a concentration of up to 30% by weight. 11. A process as claimed in claim 10 in which the ratio of carbon monoxide:hydrogen in the reactor is greater than 10:1 molar. 12. A process as claimed in any one of claims 9 and 11 in which the partial pressure of hydrogen in the reactor is up to 0.5 bar. 13. A process as claimed in any one of the preceding claims in which the reactant comprises methanol and/or a reactive derivative thereof and the carbonylation product is selected from the group consisting of acetic acid, acetic anhydride and mixtures thereof. 14. A process as claimed in claim 13 in which said carbonylation product is separated from said rhodium catalyst at a partial pressure of carbon monoxide less than that in the reactor. 15. A process for the carbonylation of a C1 to C4 alkyl alcohol and/or a reactive derivative thereof substantially as herein described with reference to the accompanying drawings.

Documents:

1329-del-1995-abstract.pdf

1329-del-1995-claims.pdf

1329-del-1995-complete specification (granted).pdf

1329-DEL-1995-Correspondence Others-(25-08-2011).pdf

1329-DEL-1995-Correspondence-Others-(07-09-2009).pdf

1329-del-1995-correspondence-others.pdf

1329-del-1995-correspondence-po.pdf

1329-del-1995-desctiption (complete).pdf

1329-del-1995-drawings.pdf

1329-del-1995-form-1.pdf

1329-del-1995-form-13.pdf

1329-del-1995-form-19.pdf

1329-del-1995-form-2.pdf

1329-DEL-1995-Form-3-(07-09-2009).pdf

1329-del-1995-form-3.pdf

1329-del-1995-form-4.pdf

1329-del-1995-form-6.pdf

1329-DEL-1995-GPA-(25-08-2011).pdf

1329-del-1995-gpa.pdf

1329-del-1995-petition-137.pdf

1329-del-1995-petition-138.pdf