| Title of Invention | A METHOD OF IDENTIFYING MOLECULE WHICH INTERACT WITH KINASE PROTEINS AND A PROTEIN MODULATOR ADDUCT |
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| Abstract | New methods for the rational identification of molecules capable of interacting with specific naturally occurring proteins are provided, in order to yield new pharmacologically important compounds and treatment modalities. Broadly, the method comprises the steps of identifying a switch control ligand forming a part of a particular protein of interest, and also identifying a complemental switch control pocket forming a part of the protein and which interacts with said switch control ligand. The ligand interacts in vivo with the pocket to regulate the conformation and biological activity of the protein such that the protein assumes a first conformation and a first biological activity upon the ligand-pocket interaction, and assumes a second, different conformation and biological activity in the absence of the ligand-pocket interaction. Next, respective samples of said protein in the first and second conformations are provided, and these are screened against one or more candidate molecules by contacting the molecules and the samples. Thereupon, small molecules which bind with the protein at the region of the pocket may be identified. Novel protein-modulator adducts and methods of altering protein activity are also provided. |
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1427-CHENP-2005 CORRESPONDENCE OTHERS.pdf
1427-CHENP-2005 CORRESPONDENCE PO.pdf
1427-CHENP-2005 DESCRIPTION (COMPLETE).pdf
1427-CHENP-2005 POWER OF ATTORNEY.pdf
1427-CHENP-2005 SEQUENCE LIST.pdf
| Patent Number | 237750 | ||||||||||||||||||||||||
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| Indian Patent Application Number | 1427/CHENP/2005 | ||||||||||||||||||||||||
| PG Journal Number | 3/2010 | ||||||||||||||||||||||||
| Publication Date | 15-Jan-2010 | ||||||||||||||||||||||||
| Grant Date | 06-Jan-2010 | ||||||||||||||||||||||||
| Date of Filing | 27-Jun-2005 | ||||||||||||||||||||||||
| Name of Patentee | DECIPHERA PHARMACEUTICALS, LLC | ||||||||||||||||||||||||
| Applicant Address | 1505 Wakarusa Drive, Lawrence, Kansas 66047 | ||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | C12Q 1/42 | ||||||||||||||||||||||||
| PCT International Application Number | PCT/US2003/041450 | ||||||||||||||||||||||||
| PCT International Filing date | 2003-12-26 | ||||||||||||||||||||||||
PCT Conventions:
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