Title of Invention

"NOVEL COMPOUNDS THAT MODULATE PPARY TYPE RECEPTORS"

Abstract

The invention relates to novel compounds corresponding to the general formula (1) below: (I) and also to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism),-or alternatively in cosmetic compositions.

Full Text

FIELD OF THE INVENTION The invention relates to a novel compounds that are modulators of receptors of PPARy (Peroxisome Proliferator-Activated Receptor type of subtype y). The invention also relates to a process for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions. BACKGROUND OF THE INVENTION The activity of receptors of PPAR type has been the subject of many studies. Mention may be made, as a guide, of the publication entitled "Differential Expression of Peroxisome Proliferator-Activated Receptor Subtypes During the Differentiation of Human Keratinocytes", Michel Rivier et al., J. Invest. Dermatol 111, 1998, pp. 1116-1121, in which is listed a large number of bibliographic references relating to receptors of PPAR type. Mention may also be made, as a guide, of the report entitled "The PPARs: From orphan receptors to Drug" Discovery", Timothy M. Willson, Peter J. Brown, Daniel D. Sternbach and Brad R. Henke, J. Med. Chem.", 2000, Vol. 43, pp. 527-550. PPAR receptors activate transcription by binding to elements of DNA sequences, known as peroxisome proliferator response elements (PPRE), in the form of a heterodimer with retinoid X receptors (known as RXRs). Three subtypes of human PPARs have been identified and described: PPARa, PPARy and PPARS (or NUC1) . PPARa is mainly expressed in the liver, while PPAR5 is ubiquitous. PPARy is the most extensively studied of the three subtypes. All the references suggest a critical role of PPARy in regulating the differentiation of adipocytes, where it is greatly expressed. It also has a key role in systemic lipid homeostasis. It has been described in particular in patent application WO 96/3,3724 that PPARy-selective compounds, such as a prostaglandin-J2 or -D2, are potential active agents for treating obesity and diabetes. Moreover, the Applicant has already described PPARy compounds and/or the use thereof in document FR 2 773 075, which describes the use of PPARy activator compounds in the preparation of a pharmaceutical composition, the composition being intended to treat skin disorders associated with an anomaly of epidermal cell differentiation. One of the aims of the present invention is to :propose a novel class of PPARy-modulating compounds that show very good specific affinity for PPARy. DETAILED DESCRIPTION OF THE INVENTION Thus, the present invention relates to compounds corresponding to the general formula (I) below: (Formula Removed) in which: - Rl represents a radical of formula (a) or (b) below: (Formula Removed) R3 and R4 having the meanings given below, - R2 represents an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, a 9-fluorenylmethyl radical or a radical of formula {CH2MNR5)n(C(O,N))pR6; R5, R6, m, n and p having the meanings given below; - R3 represents a radical chosen from the following formulae: R7, R8, V, W and Y having the meanings given below; - R4 represents an alkyl radical containing from 1 to 12 carbon atoms, a radical OR9 or a radical SR9 or NHR9; R5 and R7, which may be identical or different, represent a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical; a heteroaryl radical or a heterocyclic radical when Y represents an nitrogen atom, then formula (e) is not substituted by a radical R7; R6 and R8, which may be identical or different, represent - a radical 0- (CH2),-R10, - a hydroxyl radical, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, or - a radical (Formula Removed) - a radical NR' (CH2}vR10 R10, R', R" and v having the meanings given below; R9 represents an alkyl radical having from 1 to 12 carbon atoms or a radical chosen from the following formula: (f) (Formula Removed) (h) α-amino acid N-protected with standard amine- protecting groups, such as 9-fluorenylmethylcarbamate (FMOC), t-butylcarbamate (BOG), benzyl or trifluoro- acetyl; R11, Q and p having the meanings given below, - m may take the values 0, 1 or 2; - n and p may take the values 0 or 1; - Q represents an oxygen or sulfur atom or NR5; - V represents an oxygen, a nitrogen or sulfur atom; - W represents a nitrogen atom or a radical C-R5; - Y represents a nitrogen atom or a carbon atom; - Z represents an oxygen, nitrogen or sulfur atom; - v may take the values 1, 2 or 3; -• R10 represents an alkyl radical containing from 1 to 12 carbon atoms, an aryl, aralkyl, heteroaryl or heterocyclic radical, a radical NH-CO-R12, a radical NH-CO-0-R12 or C-R12R13 or a radical N-R12R13, R12 and R13 having the meanings given below, - R' represents a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, a heteroaryl radical or a heterocyclic radical; - R" represents a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, optionally substituted with one or more halogens, a heteroaryl radical, a heterocyclic radical, a radical (CH2)V-R10, or a radical NHR10 or NR10R10; - Rll represents a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical or a radical (CO)s(Z)tR10 with s and t possibly taking the values 0, 1 or 2; - R12 represents a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; - R13 represents a hydrogen atom or an alkyl radical containing from 1 to 12 carbon atoms; - X represents a bond having the following structure: -(CH2)z-NR14-C(T)-(D)w-D, z, T and R14 having the meanings given below, - T represents an oxygen or sulfur atom; - D represents an oxygen or sulfur atom, a radical -NR15 or a radical CH2; R15 having the meaning given below; - z may take the values 0 or 1; - w may take the values from 0 t'o 6; and - R14 and R15 represent a hydrogen atom or an alkyl radical containing from 1 to 12 carbon atoms, - Arl and Ar2 may be identical or different and represent an optionally substituted aromatic radical of formula: (Formula Removed) _. with A representing an S or 0 atom or a radical N-R13, it being understood that, when Arl or Ar2 is a phenyl radical, then Ar2 or Arl is necessarily a heteroaryl radical, and the optical and geometrical isomers of the said compounds of formula (I), and also the salts thereof. When the compounds according to the invention are in the form of a carboxylic acid salt, the said salt is preferably an alkali metal salt, in particular the sodium salt, an alkaline-earth metal salt or a salt of an organic amine, more particularly of amino acids such as arginine or lysine. When the compounds according to the invention are in the form of a salt of an amine function, for example of a pyridine, the aaid salt is preferably a salt of a halogen atom, such as the hydrochloride or the hydrobromide, or an organic acid salt, such as a fumarate or a maleate, or a nitrate. According to the present invention, the term "hydroxyl radical" means the -OH radical. According to the present invention, the expression walkyl radical containing from 1 to 12 carbon atoms" means a linear or cyclic, saturated or unsaturated, optionally branched, hydrogen-containing or fluorine-containing radical containing 1 to 12 carbon atoms, which may be interrupted with a hetero atom, and the alkyl radicals containing from 1 to 12 carbon atoms are preferably methyl, ethyl, isopropyl, butyl, tert-butyl, hexyl, heptyl, octyl, decyl, cyclohexyl or methylenecyclopropyl radicals. The term "polyether radical" means a polyether radical containing from 1 to 6 carbon atoms interrupted with at least one oxygen atom, such as methoxymethoxy, ethoxyraethoxy or methoxyethoxymethoxy radicals. The term "halogen atom" means a fluorine, chlorine or bromine atom. The term "alkoxy radical containing from 1 to 7 carbon atoms" means a methoxy, ethoxy, isopropyloxy, tert-butoxy, hexyloxy, heptyloxy, benzyloxy or phenoxy radical, which may optionally be substituted with an alkyl radical containing from 1 to 12 carbon atoms. The term "aryl radical" means a phenyl, biphenyl, cinnamyl or naphthyl radical, which may be mono- or disubstituted with a halogen atom, a CFs radical, an alkyl radical containing from 1 to 12 carbon atoms, an alkoxy radical containing from 1 to 7 carbon atoms, a nitro function, a polyether radical, an aryl radical, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl radical optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms. The term "aralkyl radical" means a benzyl, phenethyl or 2-naphthylmethyl radical, which may be mono- or disubstituted with a halogen atom, a CFs radical, an alkyl radical containing from 1 to 12 carbon atoms, an alkoxy radical containing from 1 to 7 carbon atoms, a nitro function, a polyether radical, an aryl radical, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl radical optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms. The term Mheteroaryl radical" means an aryl radical interrupted with one or more hetero atoms, such as a pyridyl, furyl, thienyl, isoxazolyl, oxadiazolyl, oxazolyl, isothiazolyl, quinazolinyl, benzothia-diazolyl, benzimidazolyl, quinoxalyl, indolyl or benzofuryl radical, optionally substituted with at least one halogen, an alkyl containing from 1 to 12 carbon atoms, an alkoxy containing from 1 to 7 carbon atoms, an aryl radical, a nitro function, a polyether radical, a heteroaryl radical, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms. The term "heterocyclic radical" preferably means a morpholino, piperidino, piperazino, 2-oxo-l-piperidyl or 2-oxo-l-pyrrolidinyl radical, optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms, an alkoxy containing from 1 to 7 carbon atoms, an aryl radical, a nitro function, a polyether radical, a heteroaryl radical, a benzoyl radical, an alkyl eater group, a carboxylic acid, a hydroxyl optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms. Among the compounds of formula (I) above that fall within the context of the present invention, mention may be made especially of the following compounds {alone or as a mixture): 1. N-{4-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenyl]- thiophen-2-ylmethyl}-N-methylbenzamide 2. N-{5-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenyl]- thiophen-3-ylmethyl}-N-methylbenzamide 3. N-{5-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenyl]- pyrid-3-ylmethyl}-N-methylbenzamide 4. N-{3-[5-(2,4-Dioxothiazolidin-5-ylmethyl)pyrid-2- yl]benzyl}-N-methyloctanoylamide 5. 2{S)-Ethoxy-3-(4-{5-[(raethyloctanoylamino)methyl]- thiophen-3-yl} phenyl) propanoic acid 6. 2(S)-Ethoxy-3-(4-{5-[(raethyloctanoylaiaino)methyl]- thiophen -2 -yl } phenyl) propanoic acid 7 . 2(3) -Ethoxy-3-t 4- [2- ( 3-heptyl-l-methylureido } -thiazol-4-yl] phenyl >propanoic acid 8. 2(S)-Ethoxy-3-{4-[2-{3-pentyl-l-methylureido)- thiazol-5-yl]phenyl} propanoic acid 9. 2 (S)-Ethoxy-3-{4-[6- (3-heptyl-l-methylureido) - pyrid-2-yl]phenyl} propanoic acid 10. 2- [4- (2-Carboxy-2 (S) -ethoxyethyDphenyl] -6- (3- heptyl-l-methylureido)pyridinium chloride 11. 2 (S) -Ethoxy-3-{4- [5- { 3-heptyl-l-methylureido) -2- raethyl-2H- [1,2,4] triazol-3-yl] phenyl }propanoic acid 12. { 3- [5- { 2, 4-Dioxothiazolidin-5-ylrtiethyl) thiophen-2- yl] benzyl }methyloctanoylcarboxylamide 13. {3-[5-{2,4-Dioxothiazolidin-5-ylmethyl]thiophen-2- yl] benzyl }methylhexanoylcarboxylamide 14 . 2 (S) - (2-Benzoylphenylamino) -3- (4-{ 5- [ (methyl-octanoylamlno) methyl] thiophen-3-yl} phenyl) -propanoic acid 15. 2(S)-{2-Benzoylphenylamino)-3-(4-{5-[{hexanoyl- methylamino) methyl] thiophen-3-yl } phenyl) propanoic acid 16. 2{S)-Ethoxy-3-(4-{5-[(hexanoylmethylamino)- methyl] thiophen-3-yl }phenyl) propanoic acid 17. 2 (S)-Ethoxy-3-(4-(5-[ (methylpentanoylamino) - methyl]thiophen-3-yl}phenyl)propanoic acid 18. 3-[4-(5-{ [ (2-Cyclopentylacetyl)methylamino]- methyl}thiophen-3-yl)phenyl]-2(S)-ethoxypropanoic acid 19. 3-[4- (5-{ [ (3-Cyclohexylpropionyl)methylamino]- methyl}thiophen-3-yl)phenyl3-2(S)-ethoxypropanoic acid 20,. 2~Ethoxy-3-{6- [3- (3-heptyl-l-methylureido)phenyl] -pyrid-3-yl}propanoic acid 21. 2(S)-(2-Benzoylphenylamino)-3-{4-[6-(l-methyl-3- pentylureido)pyrid-2~yl]phenyl}propanoic acid 22. 2(S)-(2-Benzoylphenylamino)-3-{4-[6-(3-heptyl-l- methylureido) pyrid-2-yl]phenyl}propanoic acid 23. 2(S)-Ethoxy-3-{6-[3-(3-heptyl-l-methylureido)- phenyl]pyrid-3-yl}propan'oic acid 24. 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-pentylureido)- pyrid-2-yl]phenyl}propanoic acid hydrochloride 25. 3-{4~[6-(3-Butyl-l-methylureido)pyrid-2-yl]- phenyl}-2 (S)-ethoxypropanoic acid 26. 2{S)-Ethoxy-3-{4-[6-(l-methyl-3-phenethylureido)- pyrid-2-yl]phenyl}propanoic acid hydrochloride 21. 2 (S) -Ethoxy-3-{4-[6-(1-methyl-3-phenylureido) - pyrid-2-yl]phenylJpropanoic acid 28 . 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-naphthalen-2- ylureido)pyrid-2-yl]phenyl}propanoic acid 29. 3-{4-[6-(3-Cyclohexyl-l-methylureido)pyrid-2- yl]phenyl}-2(S)-ethoxypropanoic acid 30. 2(S)-Ethoxy-3-{4-[3-(3-heptyl-l-methylureido)- phenyl]thiazol-2-yl}propanoic acid 31. 2 (S) -Ethoxy-3-'{4- [3- (l-methyl-3-pentylureido) - phenyl]thiazol-2-yl}propanoic acid 32. 2(S)-Ethoxy-3-{6-[3-(l-methyl-3-pentylureido)- phenyl]pyrid-3-yl)propanoic acid 33. 2(S)-Ethoxy-3-[4-(6-{3-[2-(4-fluorophenyl)ethyl]- 1-methylureido}pyrid-2-yl)phenyl]propanoic acid 34. 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-pentylureido)- pyrid-2-yl]phenyl}propanoic acid 35. 2(S)-Ethoxy-3-{4-[4-(3-heptyl-l-methylureido)- pyrid-2-yl]phenyl}propanoic acid 36. 2 (S)-Ethoxy-3-{4-[4-(l-methyl-3-pentylureido) - pyrid-2-yl]phenyl}propanoic acid 37. 2(S)-Ethoxy-3-{4-[2-(l-methyl-3-pentylureido)- pyrid-4-yl]phenyl}propanoic acid 38. 2(S)-Ethoxy-3-{4-[2-(3-heptyl-l-methylureido)- pyrid-4-yl]phenyl}propanoic acid 39. 2(S)-Ethoxy-3-{4-[2-(3-heptyl-l-methylureido)- pyrimidin-4-yl]phenyl}propanoic acid 40. 2(S)-Ethoxy-3-{4-[2-(l-methyl-3-pentylureido)- pyrimidin-4-yl]phenyl}propanoic acid 41. 2(S)-Ethoxy-3-{5-[3-(3-heptyl-l-methylureido)- phenyl]furan-2-yl}propanoic acid 42. 2(S)-Ethoxy-3-{5-[3-{3-heptyl-l-methylureido)- phenyl]thiophen-2-yl)propanoic acid 43. 2(S)-Ethoxy-3-{2-[3-(3-heptyl-l-methylureido)- phenyl]pyrimidin-5-yl}propanoic acid 44. 2(8)-Ethoxy-3-{6-[3-{3-heptyl-l-methylureido)- phenyl]pyrid-3~yl}propanoic acid 45. 2 (S)-Ethoxy-3-{4-[5-(3-hepty1-1-methylureido)- thiophen-2-yl]phenyl}propanoic acid 46. 2(S)-Ethoxy-3-[4-(5-{ [methyl{6-propoxynaphthalene- 2-carbonyl)amino]methyl}furan-2-yl)phenyl]- propanoic acid 47. 2 (S)-Ethoxy-3-{4-[5-{3-heptyl-l-methylureido)- furan-2-yl]phenyl}propanoic acid 48. 2(S)-Ethoxy-3-[4-(5-{[methyl{6-propoxynaphthalene- 2-carbonyl)amino]methyl}thiophen-2-yl)phenyl]- propanoic acid 49. 2(S)-Ethoxy-3-[4-(4-{[methyl(6-propoxynaphthalene- 2-carbonyl)amino]methyl}thiophen-2-yl)phenyl]- propanoic acid 50. 3-(6-{3-[3-(4-Dimethylaminophenyl)-1-methyl- ureido]phenyl}pyrid-3-yl)-2(S)-ethoxypropanoic acid 51. 2 (S)-Ethoxy-3-[6-{3-{[methyl-(6-propoxy- naphthalene-2-carbonyl)amino]methyl}phenyl)pyrid- 3-yl]propanoic acid 52. 2(S)-Ethoxy-3-(6-{3-[(heptanoylmethylamino)- methyl]phenyl}pyrid-3-yl}propanoic acid 53. 2(S)-Ethoxy-3-(6-{3-[(hexanoylmethylamino)methyl]- phenyl}pyrid-3-yl)propanoic acid 54. 2(S)-Ethoxy-3-(4-{5-[{methyloctanoylamino)methyl]- furan-2-yl}phenyl)propanoic acid 55. N-{3-[5-{3-Hydroxy-2(S)-phenylaminobut-3-enyl)- pyrid-2-yl]benzyl}"N-methyloctanoylcarboxylamide 56. 2(S)-Ethoxy-3-[6'-(3-heptyl-l-methylureldo)- ' [2,2']bipyridyl-5-yl]prbpanoic acid 57. l-(3-{2-[2(S)-Ethoxy-3-(4-methylpiperid-l-yl)-3- oxopropyl]thiazol-4-yl}phenyl) -l-methyl-3-pentyl- urea 58. 1-{3-{5-[2 (S)-Ethoxy-2-(5-propyl[1,3,4]oxadiazol- 2-yl)ethyl]pyrimidin-2-yl)phenyl)-3-heptyl-l- methylurea 59. l-{6-[4-(2(S)-Ethoxy-3-oxo-3-piperid-l-ylpropyl)- phenyl]pyrid-2-yl}-l-methyl-3-pentylurea 60. 1-(6-{4- [2(S)-Ethoxy-3-(4-methylpiperid-l-yl)-3- oxopropyl]phenyl}pyrid-2-yl)-l-methyl~3-pentylurea 61. l-{6-[4-(2(S)-Ethoxy-3-morpholin-4-yl-3-oxo- propyl]phenyl]pyrid-2-yl}-l-methyl-3-pentylurea 62. 2 (S) -Ethoxy-3- (4-{5- [ (hexanoylmethylarrd.no) methyl] - thiophen-3-yl}phenyl)propanoic acid 63. {4-[4-(2(S)-Ethoxy-3-oxo-3-piperid-l-ylpropyl)- phenyl] thiophen-2-ylmethyl }methylhexanoylcarboxyl- amide 64. {4-{4-[2(S)-Ethoxy-3-(4-methylpiperid-l-yl)-3- oxopropyl]phenyl}thiophen-2-ylmethyl)methyl- hexanoylcarboxylamide 65. {4-[4- (2 (S)-Ethoxy-3-morpholin-4-yl-3-oxopropyl)- phenyl]thiophen-2-ylmethyl}methylhexanoylcarboxyl~ amide 66. {4-[4-(2{S}-Ethoxy-3-oxo-3-piperid-l-ylpropyl)- phenyl]thiophen-2-ylmethyl }methyloctanoylcarboxyl- amide 67. (4-{4-[2 (S)~Ethoxy-3-(4-methylpiperid-l-yl)-3- oxopropyl] phenyl} thiophen-2-ylmethyl) methyl- octanoylcarboxylamlde 68. l-{3-[5- (2(S)-Ethoxy-3-oxo-3-piperid-l-ylpropyl)- pyrid-2-yl]phenyl}-l-methyl-3-pentylurea 69. 1-(3-{5- [2(S)-Ethoxy-3-(4-methylpiperid-l-yl)-3- oxopropyl]pyrid-2-yl}phenyl) -l-methyl-3-pentylurea 70. l-{3-[5- {2 (S)-Ethoxy-3-morpholin-4-yl-3-oxo- propyl)pyrid-2-yl]phenyl}-l-methyl-3-pentylurea 71. l-{3- [2- (2, 4-Dioxothiazolidin-5-ylmethyl) - pyrimidin-5-yl]phenyl}-3-heptyl-l-methylurea 72. l-{3- [2- (2,4-Dioxothiazolldin-5-ylmethyl)- pyrimidin-5-yl] phenyl}-l-methyl-3-pentylurea 73. 2(S)-Ethoxy-3-{5-[3-(l-methyl-3-pentylureido}- phenyl]pyrimidin-2-yl}propanoic acid 74. 2(S)-Ethoxy-3-{6-[4-fluoro-3-(l-methyl-3-pentyl- ureido)phenyl]pyrid-3-y1}propanoic acid 75. 2 {S)-Ethoxy-3-{2-fluoro-4-[6-(l-methyl-3-pentyl~ ureido)pyrid-2-yl]phenyl}propanoic acid 76. 2{S)-Ethoxy-3-{4-[5-(l-methyl-3-pentylureido)- thiophen-2-yllphenyl}propanoic acid 77. 2(S)-Ethoxy-3-{4-[5-(3-heptyl-l-methylureido)- thiophen~2-yl]phenyl}propanoic acid 78. 2(S)-Methylamino-3-(4-{5-[ (methyloctanoylamino)- methyl]thiophen-3-yl}phenyl)propanoic acid 79. 2(S)-Ethylamino-3-(4-{5-[(methyloctanoylamino)- methyl]thiophen-3-yl}phenyl)propanoic acid 80. 2(S)-Ethylamino-3-(4-{5-[(hexanoylmethylamino)- methyl]thiophen-3-yl}phenyl)propanoic acid 81. 3-(4-{5-[(Hexanoylmethylamino) methyl]thiophen-3- yl}phenyl)-2(S)-methylaminopropanoic acid 82. 2(S)-Ethylamino-3-{4-[6-(l-methyl-3-pentylureido)- pyrid-2-yl]phenyl}propanoic acid 83. 2 (S)-Ethylamino-3-{4-[6-(3-heptyl-l-methylureido)- pyrid-2-yl]phenyl)propanoic acid 84. 3-{4-[6-(3-Heptyl-l-methylureido)pyrid-2-yl]- phenyl}-2(S)-methylaminopropanoic acid 85. 2(S)-Methylamino-3-14-[6-(l-methyl-3-pentyl- ureido)pyrid-2-yl]phenyl}propanoic acid 86. 2{S)-Cyclopropylmethoxy-3-(4-[6-(l-methyl-3- pentylureido)pyrid-2-yl]phenyl}propanoic acid 87. 2(S)-Ethoxy-3-[6'-(l-methyl-3-pentylureido)- [2,2'lbipyridyl-5-yl]propanoic acid 88. 2(3)-Ethoxy-3-{6-{5-[(methyloctanoylamino)methyl]- thiophen-3-yl}pyrid-3-yl)propanoic acid 89. 2(S)-Ethoxy-3-(6-{5-[(hexanoylraethyland.no) methyl]- thiophen-3-yl}pyrid-3-yl)propanoic acid 90. 2-[4-(2-Carboxy-2(S)-ethoxyethyl)phenyl]-6-(3- heptyl-1-methylureido)pyridinium fumarate 91. 2-[4-(2-Carboxy-2(S)-ethoxyethyl)phenyl]-6-{3- heptyl-1-methylureido)pyridinium maleate 92. 3-{4-[6-(l-Methyl-3-pentylureido)pyrid-2-yl]- phenyl}-2(S)-propoxypropanoic acid . 93. 2(S)-Isopropoxy-3-{4-[6-{l-methyl-3-pentylureido)- pyrid-2-yl]phenyl}propanoic acid 94. 2(S)-Ethoxy-3-[4-{5-{[(3-lH-indol-3-ylpropionyl)- methylamino]methyl}thiophen-3-yl)phenyl]propanoic • acid 95 . 3-{4-[6- (3-Pentyl-l-methylureido)pyrid-2-yl]-phenyl}-2~methylpropanolc acid 96. 3-{4-[6-{3-Heptyl-l-methylureido)pyrid-2-yl]- phenyl}-2-methylpropanoic acid 97. 2-Methyl-3-{4-{5-[ (methyloctanoylaitiino)methyl] - thiophen-2-yl}phenyl)propanoic acid 98. 3-{6-[3-(3-Heptyl-l-methylureido)phenyl]pyrid-3- yl}-2-methylpropanoic acid 99. 2 (S)-Ethoxy-3-(4-{4-[l-methyl-3-(2-piperidin-l-yl- ethyl)-ureido]-pyridin-2-yl}-phenyl}-propanoic acid 100. 2(S)-Ethoxy-3-(4-{4-[l-methyl-3-{3-phenyl-propyl)'- ureido]-pyridin-2-yl}-phenyl)-propanoic acid 101. 2(S)-Ethoxy-3-(4-{4-[l-methyl-3-(4-phenyl-butyl)- ureido]-pyridin-2-yl}-phenyl) -propanoic acid 102. 3-{4-[4-{3-Benzo[l,2,5]thiadiazol-4-yl-l-methyl- ureido)-pyridin-2-yl]-phenyl}-2(S)-ethoxy- propanoic acid 103. 3-(4-{4-[3-(4-Dimethylamino-phenyl)-l-methyl- ureido]-pyridin-2-yl}-phenyl)-2(S)-ethoxy- propanoic acid 104. 2 (S)-Ethoxy-3-[4-(4-{3-[2-(lH-imidazol-2-yl)- ethyl]-1-methyl-ureido}-pyridin-2-yl)-phenyl]- propanoic acid 105. 3-(4-{4-[3-(2-Dimethylamino-ethyl)-1-methyl- ureido].-pyridin-2-yl}-phenyl) -2 (S) -ethoxy- propanoic acid 106. 2(3)-Ethoxy-3-{4-t4-(l-methyl-3-naphthalen-2-yl- ureido)-pyridin-2-yl]-phenyl}-propanoic acid 107. 3-{4-[6-(3-Benzo[l,2,5]thiadiazol-4-yl-l~methyl- ureido)-pyridin-2-yl]-phenyl}-2(S)-ethoxy- propanoic acid 108. 2(3)-Ethoxy-3-(4-{6-[l~methyl-3-(3-phenyl-propyl)- ureido]-pyridin-2-yl}-phenyl)-propanoic acid 109 . 2(S)-Ethoxy-3-{4-{6-[l-methyl-3-(2-piperidin-l-yl-ethyl)-ureido]-pyridin-2-yl}-phenyl)-propanoic acid 110. 2 (S)-Ethoxy-3-(4-{6-[l-methyl-3-(4-phenyl-butyl)- ureido]-pyridin-2-yl}-phenyl)-propanoic acid 111. 3-(4-{6-[3-(4-Dimethylamino-phenyl)-1-methyl- ureido]-pyridin-2-yl}-phenyl)-2(S)-ethoxy- propanoic acid 112. 3-{4-{6-[3-{2-Dimethylamino-ethyl)-1-methyl- ureido]-pyridin-2-yl}-phenyl)-2(S)-ethoxy- propanoic acid 113 . 2(S)-Ethoxy-3-[4-(6-{3-[2-(lH-iraidazol-2-yl)- ethyl]-l-methyl-ureido}-pyridin-2-yl)-phenyl]-propanoic acid 114 . 2(3)-Ethoxy-3-{4-[6-(l-methyl-3-pentyl- thioureido)-pyridin-2-yl]-phenyl}-propanoic acid 115. 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-heptyl- thioureido)-pyridin-2-yl]-phenyl}-propanoic acid 116. 2(5)-Ethoxy-3-{6-[3-(3-heptyl-l-methyl- thioureido)-phenyl]-pyridin-3-yl}-propanoic acid 117. 2 thioureido)-pyridin-2-yl]-phenyl}-propanoic acid 118. 2(3)-Ethoxy-3-(6-{3-[l-methyl-3-(2-piperidin-l-yl- ethyl)-ureido]-phenyl}-pyridin-3-yl)-propanoic acid 119. 3-(6-{3-[3-(2-Benzo[1,2,5]thiadiazol-4-yl-ethyl)- 1-methyl-ureido]-phenyl}-pyridin-3-yl)-2(S)- ethoxy-propanolc acid 120 . 2(S)-Ethoxy-3-(6-{3-[l-methyl-3-{3-phenyl-propyl)- ureido]-phenyl}-pyridin-3-yl)-propanoic acid 121. 3-(6-{3-[3-{4-Dimethylamino-phenyl)-l-methyl-ureido]-phenyl}-pyridin-3-yl)-2(S)-ethoxy-propanoic acid. According to the present invention, the compounds of formula (I) that are more particularly preferred are those that have at least one of the following characteristics: - Rl represents a radical of formula (a) or (b); in the case where Rl corresponds to formula (b), R3 is preferably a radical of formula (d) with R8 being a hydroxyl, NR'R" or heterocyclic radical and R4 preferably being a radical of formula OR9 in which R9 is an alkyl of 1 to 12 carbon atoms or a group of formula (f) with Rll being a hydrogen or a group COOR10; - R2 represents an alkyl, aryl or heteroaryl radical'; - X represents the bond of structure -CHaN (Ru)CO- or -N(Ru)-CO-(D)w- with w - 0 or 1; - the preferred compounds contain at least one group Arl or Ar2 of pyridine, thiazole, pyrimidine, thiophene or triazole type. A general description of the preparation of the compounds of general formula (I) with Rl of formula (b), such as compounds 12 to 16 and 25 to 30 of Figures 1, 2, 3 and 4 attached hereto, is given below. The reaction scheme described in Figure 1 is a general scheme for obtaining monoheterocyclic or diheterocyclic derivatives. It is particularly used in the case where Ar2 is a phenyl, since compound 2 is then commercially available. Compound 1 with R"r equal to NRuG may be obtained from the amino derivative by monoprotection, for example with a protecting group G, for example of *boc", "fmoc" or acetyl type, followed by an alkylation with an alkyl halide in the presence of a base such as sodium hydride. Compound 1 for which R"' is equal to CH2NRnG is generally prepared via a reductive amlnation reaction on an aldehyde function. The intermediate 3 is obtained via a Suzuki coupling between an arylboronic acid, such as 4-formyl-benzeneboronic acid, or a heteroarylboronic acid, which is commercially available or prepared beforehand from the corresponding halo derivative, and a halogenated heteroaryl derivative, for instance (6-bromo-2-pyridyl)methylamine or (5-bromo-2-thiazolyl)methyl-amine, optionally protected with a group G as defined above. Compound 4 is prepared by coupling an Evans chiral reagent, for example (S)-4-benzyloxazolidin-2-one, and an acid chloride, for example of an alkoxy-acetic or aralkoxyacetic acid in the case of Y=0r which is preferably commercially available, in the presence of a base, for example butylllthium. The chiral intermediate 5 is obtained via enantioselective addition of compound 4 to the intermediate 3, in the presence of a boron derivative. Compound 6 is obtained by dehydroxylation of compound 5 using the Barton reaction: formation of a thiocarbonic bond between the hydroxyl group to be removed and the phenyl chlorothionoformate, followed by heating to 110°C in the presence of tributyltin hydride and a free-radical agent, AIBN. The intermediates 9 and 11 may be prepared after deprotection of the amine (-G) by addition to an isocyanate or a thioisocyanate if D = NRj.5 or to an acid halide if D = CH2. The hydrolysis of the benzyloxazolidin-2-one part to give compound 12 is performed under conditions that allow conservation of the stereochemistry of the C-ORg, for example with 1.5 equivalents of aqueous 1M lithium hydroxide solution in tetrahydrofuran, at room temperature. The heterocyclic compounds 13 and 14 are synthesized via standard methods for synthesizing heterocycles, with, in the case of compound 14, condensation of butyric hydrazide and cyclization by heating to 105°C in the presence of phosphorus oxychloride. The esters 15 may be prepared, for example, by esterification with alcohols HO{CH2)vRio« The compounds 16 are obtained via an amidation reaction with an amine of the type HNR'R". Another reaction route for obtaining compounds 12 to 16 is described in Figure 2. The variation of the reaction scheme arises essentially in the production of the derivative 5. Specifically, the intermediate 5 may also be obtained as described in Figure 2 via a Suzuki coupling between the boronic acid 18 and the derivative 19, which is an analogue of compound 34 for which G = R9. This synthetic route is particularly suitable for obtaining derivatives for which Arl is a phenyl. When Arl is an aromatic heterocycle, the corresponding boronic acid should be prepared beforehand according to the standard methods. The derivative 19 is obtained according to the scheme described in Figure 5: the preparation of compound 32 is performed by coupling an Evans chiral reagent, for example (S)-4-benzyloxazolidin-2-one, and an acid chloride, the function Y optionally being protected with a group G or alkylated, which is preferably commercially available, in the presence of a base, for example butyllithium. The condensation of the derivative 32 with the halogenated aldehyde 31 allows the production of compound 33. Via a Barton dehydroxylation reaction, compound 34, or 19 when the function Y is alkylated with a group R9, is obtained. Derivative 34 is obtained by dehydroxylation of compound 33 using the Barton reaction, the chiral intermediate 33 having been obtained by enantio- selective addition of compound 32 to the halogenated aromatic aldehyde 31, in the presence of a boron derivative. For the compounds with Y equal to N and Ar2 being a phenyl, the intermediate 36 may be obtained from the methyl ester of 4-bromophenylalanine (L or D) or the methyl ester of tyrosine (L or D) by addition to an acid halide (n = 1) or alkylation using an alkyl halide (n = 0). Another synthetic route described in Fignraa 3 and 4 may be used. Intermediate 20 is obtained via a Suzuki coupling between the arylboronic acid 18, such as 3-formylbenzeneboronic acid, or the heteroarylboronic acid, which is commercially available or prepared beforehand from the corresponding halo derivative, and derivative 36 {Figure 3). Compound 20 may also be obtained via a Suzuki reaction between a halogenated heteroaryl derivative and a boronic derivative 51 prepared beforehand. This route is often followed in the case of a group Ar2 such as a phenyl (Figure 4). Intermediate 36 may be prepared from compound 34 as shown in Figur* S, after deprotection of the amine (-G) via addition to an acid halide (n = 1} or alkylation with an alkyl halide (n = 0). Another route for preparing compound 36, in the case of Ar2 equal to a phenyl, consists in opening a chiral epoxide, for example 2(3)-methyl glycidate, with a monocuprate derivative formed from 1,4-dibromo- benzene, followed by an enantioselective acylation or alkylation, for example in the presence of an alkyl halide and silver oxide. Compound 51 is then obtained by reacting compound 36 with bis(pinacolato)diborane in the presence of a palladium-based catalyst and potassium acetate in dimethylformamide. Intermediates 22 and 24 may be prepared after deprotecting the amine (-G) {compounds 21 and 23) by addition to an isocyanate or a thioisocyanate if D = NRis or to an acid halide if D •= CH2. The hydrolysis of the benzyloxazolidin-2-one or alkyl eater part to give compound 25 is performed under conditions that allow the stereochemistry of the C-ORg to be conserved, for example with 1.5 equivalents of aqueous 1M lithium hydroxide solution in tetrahydro-furan, at room temperature. Compound 25 thus obtained is converted into compounds 26, 27, 28 and 29 according to the methods described successively for obtaining the derivatives 13, 14, 15 and 16. A general description of the preparation of the compounds of general formula (I) with Rl of formula (a) (compound 44 of Figures 6 and 7 attached hereto) is given below. The reaction scheme described in Figure 6 is a general scheme for obtaining monoheterocyclic or diheterocyclic derivatives for which the variations of groups R2 are produced at the end of the synthesis. The condensation of 2,4-thiazolidinedione with the aldehyde 3 {obtained as described above) in the presence of piperidinium acetate, for example, gives compound 37. Intermediate 38 is obtained by reduction of the nitro function with tin chloride in the presence of hydrochloric acid. Intermediates 39 and 40 are obtained by deprotection of the amine (-G). Compounds 41 and 42, which may be grouped together under compound 43 (Z = 0 or Z = 1, respectively) may be prepared by addition to an isocyanate or a thioisocyanate if D = NR15 or to an acid halide if D - CH2. Compound 44 is obtained, for example, by hydrogenation of compound 43 under a pressure of 3 atmospheres, in the presence of palladium-on-charcoal in a solvent, for instance dioxane. The reaction scheme described in Figure 7 is a scheme for which the various groups R2 are introduced at the start of the synthesis. Compound 45 is obtained by reduction of the nitro function of compound 1. Intermediates 46 and 47 are obtained by deprotection of the amine function (-G). Intermediates 48 and 49 are obtained by addition to an isocyanate or a thioisocyanate if D = NRis or to an acid halide if D - CHZ. Via a Suzuki reaction between compounds 48 or 49 and the boronic acid 2, compound 50 is obtained. The condensation of 2,4-thiazolidinedione with the aldehyde 50, i.e. compound 41ifz=0or compound 42 if z = 1 (obtained as described above) in the presence of piperidinium acetate, for example, gives compound 43. Compound 44 is obtained, for example, by hydrogenation of compound 43 under a pressure of 3 atmospheres, in the presence of palladium-on-charcoal, in a solvent, for instance dioxane. The compounds according to the invention show modulatory properties on receptors of PPAR type. This activity on the PPARa, 6 and y receptors is measured in a transactivation test and quantified via the dissociation constant Kdapp (apparent), as described in Example 29. The preferred compounds of the present invention have a dissociation constant of less than or equal to 5000 hM and advantageously less than or equal to 1000 nM. Preferably, the compounds are modulators of receptors of specific PPARy type, i.e. they have a ratio between the Kdapp for the PPARa and PPARS receptors, and the Kdapp for the PPARy receptors, of greater than or equal to 10. Preferably, this ratio PPARy/PPARa or PPARy/PPARS is greater than or equal to 50 and more advantageously greater than or equal to 100. A subject of the present invention is also, as medicinal products, the compounds of formula (I) as described above. A subject of the present invention is the use of the compounds of formula (I) to manufacture a composition for regulating and/or restoring the metabolism of skin lipids. The compounds according to the invention are also particularly suitable in the following fields of treatment: 1} for treating dermatologies1 complaints associated with a keratinization disorder relating to differentiation and to proliferation, in particular for treating common acne, comedones, polymorphs, rosacea, nodulocystic acne, acne conglobata, senile acne and secondary acne such as solar, medicinal or occupational acne, 2) for treating other types of keratinization disorder, in particular ichthyosis, ichthyosiform conditions, Darier's disease, palmoplantar keratoderma, leukoplakia and leukoplakiform conditions, and cutaneous or mucous (oral) lichen, 3) for treating other dermatological complaints with an inflammatory immuno-allergic component, with or without a cellular proliferation disorder, and in particular all forms of psoriasis, whether cutaneous, mucous or ungual psoriasis, and even psoriatic arthritis, or alternatively cutaneous atopy such as eczema, or respiratory atopy or gingival hypertrophy, 4) for treating all dermal or epidermal proliferations, whether benign or malignant, whether or not of viral origin, such as common warts, flat warts and epldermodysplasia verruciformis, oral or florid papillomatoses, T lymphoma and proliferations which may be induced by ultraviolet light, in particular in the case of basal cell and spinocellular epithelioma, and also any precancerous skin lesion such as keratoacanthomas, 5) for treating other dermatological disorders such as immune dermatitidea, such as lupus erythematosus, bullous immune diseases and collagen diseases, such as scleroderma, 6} in the treatment of dermatological or systemic complaints with an immunological component, 7) in the treatment of skin disorders due to exposure to UV radiation, and also for repairing or combating ageing of the skin, whether light-induced or chronological ageing, or for reducing actinic keratoses and pigmentations, or any pathology associated with chronological or actinic ageing, such as xerosis, 8) for combating sebaceous function disorders such as the hyperseborrhoea of acne, simple seborrhoea or seborrhoeic dermatitis, 9) for preventing or treating cicatrization disorders or for preventing or repairing stretch marks, 10) in the treatment of pigmentation disorders, such as hyperpigmentation, melasma, hypopigmentation or vitiligo, 11) in the treatment of lipld metabolism complaints, such as obesity, hyperlipidaemia, non- insulin-dependent diabetes or syndrome X, 12) in the treatment of inflammatory complaints such as arthritis, 13) in the treatment or prevention of cancerous or precancerous conditions, 14) in the prevention or treatment of alopecia of various origins, in particular alopecia caused by chemotherapy or radiation, 15) in the treatment of immune system disorders, such as asthma, type I sugar diabetes, multiple sclerosis or other selective dysfunctions of the immune system, or 16) in the treatment of complaints of the cardiovascular system, such as arteriosclerosis or hypertension. A subject of the present invention is also a pharmaceutical or cosmetic composition comprising, in a physiologically acceptable medium, at least one compound of formula (I) as defined above. The composition according to the invention may be administered enterally, parenterally, topically or ocularly. The pharmaceutical composition is preferably packaged in a form that is suitable for topical application. Via the enteral route, the composition, more particularly the pharmaceutical composition, may be in the form of tablets, gel capsules, sugar-coated tablets, syrups, suspensions, solutions, powders, granules, emulsions or lipid or polymer vesicles or nanospheres or microspheres to allow controlled release. Via the parenteral route, the composition may be in the form of solutions or suspensions for infusion or for injection. The compounds according to the invention are generally administered at a daily dose of about 0.001 mg/kg to 100 mg/kg of body weight in 1 to 3 dosage intakes. The compounds are used systemically at a concentration generally of between 0.001% and 10% by weight and preferably between 0.01% and 1% by weight relative to the weight of the composition. Via the topical route, the pharmaceutical composition according to the invention is more particularly intended for treating the skin and mucous membranes and may be in the form of ointments, creams, milks, salves, powders, impregnated pads, syndets, solutions, gels, sprays, foams, suspensions, stick lotions, shampoos or washing bases. It may also be in the form of suspensions of lipid or polymer vesicles or nanospheres or microspheres or polymer patches and hydrogels to allow controlled release. This topical-route composition may be in anhydrous form, in aqueous form or in the form of an emulsion. The compounds are used topically at a concentration generally of between 0.001% and 10% by weight, preferably between 0.01% and 1% by weight relative to the total weight of the composition. The compounds of formula (I) according to the invention also find an application in the cosmetic field, in particular in body and hair hygiene and more particularly for regulating and/or restoring skin lipid metabolism. A subject of the invention is therefore also the cosmetic use of a composition comprising, in a physiologically acceptable support, at least one of the compounds of formula (I) for body or hair hygiene. The cosmetic composition according to the invention containing, in a cosmetically acceptable support, at least one compound of formula (I) or an optical or geometrical isomer thereof or a salt thereof, may usually be in the form of a cream, a milk, a lotion, a gel, suspensions of lipid or polymer vesicles or nanospherea or microspheres, impregnated pads, solutions, sprays, foams, sticks, soaps, shampoos or washing bases. The concentration of compound of formula (I) in the cosmetic composition is between 0.0001% and 2% by weight relative to the total weight of the composition. The pharmaceutical and cosmetic compositions as described above may also contain inert or even pharmacodynamically active additives as regards the pharmaceutical compositions, or combinations of these additives, and especially: - wetting agents; - flavour enhancers; - preserving agents such as para-hydroxybenzoic acid esters; - stabilizers; - humidity regulators; - pH regulators; - osmotic pressure modifiers; - emulsifiers; - UV-A and UV-B screening agents; - antioxidants, such as α-tocopherol, butylhydroxyanisole or butylhydroxytoluene, superoxide dismutase, ubiquinol or certain metal-chelating agents; - depigmenting agents such as hydroquinone, azelaic acid, caffeic acid or kojic acid; - emollients; - moisturizers, for instance glycerol, PEG 400, thiamorpholinone and derivatives thereof, or urea; - antiseborrhoeic or antiacne agents, such as S-carboxymethylcysteine, S-benzylcysteamine, salts thereof or derivatives thereof, or benzoyl peroxide; - antibiotics, for instance erythromycin and its esters, neomycin, clindamycin and its esters, and tetracyclines; - antifungal agents such as ketoconazole or polymethylene-4,5-isothiazolidones-3; - agents for promoting regrowth of the hair, for instance Minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) and its derivatives, Diazoxide (7-chloro-3- methyl-l,2,4-benzothiadiazine 1,1-dioxide) and Phenytoin (5r4-diphenylimidazolidine-2, 4-dione); - non-steroidal anti-inflammatory agents; - carotenoids, and especially fJ-carotene; - antipsoriatic agents such as anthralin and its derivatives; - eicosa-5,8,11,14-tetraynoic acid and eicosa-5,8,11- triynoic acid, and esters and amides thereof; - retinoids, i.e. RAR or RXR receptor ligands, which may be natural or synthetic; - corticosteroids or oestrogens; - α-hydroxy acids and α-keto acids or derivatives thereof, such as lactic acid, malic acid, citric acid, glycolic acid, mandelic acid, tartaric acid, glyceric acid or ascorbic acid, and also the salts, amides or esters thereof, or p-hydroxy acids or derivatives thereof, such as salicylic acid and the salts, amides or esters thereof; - ion-channel blockers such as potassium-channel blockers; - or alternatively, more particularly for the pharmaceutical compositions, in combination with medicinal products known to interfere with the immune system (for example cyclosporin, FK 506, glucocorticoids, monoclonal antibodies, cytokines or growth factors, etc.). Needless to say, a person skilled in the art will take care to select the optional compound(s) to be added to these compositions such that the advantageous properties intrinsically associated with the present invention are not, or are not substantially, adversely affected by the envisaged addition. Another subject of the invention relates to a cosmetic process for beautifying the skin, characterized in that a composition comprising at least one compound of formula (I) as defined above is applied to the skin. Regulation and/or restoration of the metabolism of the skin lipids makes it possible to obtain skin whose surface appearance is embellished. Several examples of the production 6f active compounds of formula (I) according to the invention, and also biological activity results for such compounds and various concrete formulations based on its compounds will now be given, by way of illustration and with no limiting nature. Example 1: H-{4-[4-(2,4-Dioxothi»zolidin-5-ylmethyl)-ph«nyl ] thiophan-2-y line thy 1} ~N-methylbenzam±da (a) (4-Bromothiophen-2-ylmethyl)methylamine 18 g {260 mmol) of methylamine hydrochloride and then 7.5 g (100 mmol) of sodium cyanoborohydride are successively added to a solution of 10 g (50 mmol) of 4-bromo-2-thiophenecarboxaldehyde in 150 ml of methanol. The reaction medium is stirred at room temperature for 24 hours and then filtered under vacuum. After evaporating the filtrate to drynesa, the residue is taken up in dichloromethane. The organic phase obtained is washed with 1N hydrochloric acid solution. The aqueous phase thus obtained is treated with aqueous 1N sodium hydroxide solution and extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated under vacuum. 4.5 g (44%) of (4-bromothiophen-2-ylmethyl)-methylamine are obtained. (b) W- {4-Bromothiophen-2-ylmethyl)-W-methylbenzamide 2.8 ml (24 mmol) of benzoyl chloride are added dropwise to a solution of 4.5 g (22 mmol) of (4-bromothiophen~2-ylmethyl)methylamine and 6 ml {44 mmol) of triethylamine in 75 ml of tetrahydrofuran. After stirring at room temperature for 1 hour, the precipitate is filtered off and the filtrate is concentrated under vacuum. The residue is taken up in dichloromethane and washed with water. The organic phase obtained is dried over magnesium sulfate, filtered and concentrated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with an 8/2 heptane/ethyl acetate mixture. 4.8 g (71%) of N-(4- bromothlophen-2-ylmethyl) -N-methylbenzamide are obtained in the form of an oil. (c) N- [4- (4-Formylphenyl) thiophen-2-ylmethyl] -AMnethyl- benzamide 3 g (20 mmol) of 4-formylbenzeneboronic acid are added to a solution of 4.75 g (15 romol} of N-(4-bromothiophen-2-ylmethyl}-N~methylbenzamide in 60 ml of toluene, followed by dropwise addition of 5.5 g (40 mmol) of aqueous potassium carbonate solution. The reaction medium is degassed, 530 mg (0.5 mmol) of tetrakis [lacuna] palladium are then added and the medium is heated at 80°C for 18 hours. After extraction with ethyl acetate and washing with water, the organic phase is dried over magnesium sulfate, filtered and concentrated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 1/1 heptane/ethyl acetate mixture. 4 g (78%) of N-[4-(4-formylphenyl)thiophen-2-ylmethyl]-N-methyl-benzamide are obtained. (d) N-{4-[4-(2,4-Dioxothiazolidin-5-ylideneraethyl)- phenyl]thiophen-2-ylmethyl}-N-methylbenzamide A solution of 4 g (9 romol) of N-[4-(4-formylphenyl) thiophen-2-ylmethyl]-N-methylbenzamide, 1.1 g (9 mmol} of 2,4-thiazolidinedione and 0.3 g (1.8 mmol) of piperidinium acetate in 40 ml of toluene is refluxed for 2 hours in a Dean-Stark system. The reaction medium is cooled and the precipitate is filtered off under vacuum. 3 g (78%) of W-{4-t4-(2,4-dioxothiazolidin-5-ylidenemethyl) phenyl] thiophen-2-ylmethyl}-JW-methyl-benzamide are obtained. (e) N-{4-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenyl]-thiophen-2-ylmethyl}-N-methylbenzamide 2 g (1 mass equivalent) of palladium-on-charcoal are added to a solution of 2.g (4.6 mmol) of J\T-{4- [4- (2,4-dioxothiazolidin-5-ylidenemethyl) phenyl] -thiophen-2-ylmethyl }-N-methylbenzamide in 20 ml of dioxane that has been degassed beforehand, and the reaction medium is placed under 3 atm of hydrogen, at 50°C for 6 hours. After filtering off the palladium through Celite, the filtrate is concentrated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 9.5/0.5 dichloromethane/methanol mixture. 1.5 g (75%) of N-{4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenyl]~ thiophen-2-ylmethyl }-N-methylbenzamide are obtained in the form of a solid with a melting point of 134°C. 1H NMR (δ, CDC13) : 2.98-3.10 (m, 3H); 3.15 (dd, J = 22 Hz, J - 7 Hz, 1H); 3.52 (dd, J = 6.1 Hz, J -22 Hz, 1H) ; 4.53 (dd, J = 6.1 Hz, J = 15 Hz, 1H); 4.63-4.89 (m, 2H); 7.15-7.54 (m, 11H); 8.94 (a, 1H). Example 2: N- { 5- [4- (2,4-Dioxothiazolidin-5-ylmethyl) -phenyl] thiophon-3-ylmethyl} -N-methylbenxamide (a) Ethyl thiophene-3-carboxylate 13 ml (200 mmol) of thionyl chloride are added dropwise, at 0°C, to a solution of 9 g (70 mmol) of 3-thiophenecarboxylic acid and 86 mg (0.7 mmol) of 4-dimethylaminopyridine in 100 ml of ethanol. The reaction medium is stirred from 0°C to room temperature over 48 hours and then evaporated to dryness. The residue obtained is purified by chromatography on a column of silica eluted with a 1/1 heptane/dichloro-methane mixture. 10 g (91%) of ethyl thiophene-3-carboxylate are obtained. {b) Ethyl 5-bromothiophene-3-carboxylate 20 g (147 mmol) of aluminium chloride are added portionwiae to a solution of 10 g (67 mmol) of ethyl thiophene-3-carboxylate in 160 ml of dichloromethane, cooled beforehand to 0°C. The reaction medium is warmed to room temperature and a solution of 4 ml (73 mmol) of bromine in 10 ml of dichloromethane is then added. After reaction for 50 minutes at room temperature, the reaction medium is poured into a water •f ice mixture and extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 9/1 heptane/ethyl acetate mixture. 9 g (57%) of ethyl 5-bromothiophene-3-carboxylate are obtained. (c) 5-Bromothiophene-3-cartaoxylic acid 7.4 g (185 mmol) of sodium hydroxide pellets are added to a solution of 8.7 g (37 irandl) of ethyl 5-bromothiophene-3-carboxylate in 100 ml of tetrahydro-furan, 10 ml of methanol and a few drops of water. After stirring at room temperature for 18 hours, the reaction medium is taken up in ethyl acetate and washed with water. The aqueous phase obtained is acidified to pH 1 with aqueous hydrochloric acid solution and then extracted with dichloromethane. The organic phase obtained is dried over magnesium sulfate, filtered and concentrated under vacuum. 7 g (92%) of 5-bromo-thiophene-3-carboxylic acid are obtained. (d) 5-Bromothiophene-N-methyl-3-carboxylamide 4.7 g (35 mmol) of 1-hydroxybenzotriazole, 2.2 g (32 mmol) of methylamine hydrochloride and 4.5 ml (32 mmol) of triethylamine are successively added to a solution of 6.7 g (32 mmol) of 5-bromothiophene-3~ carboxylic acid in 120 ml of dichloromethane. The reaction medium is cooled to 0°C and a solution of 6,7 g (35 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is added dropwise. After 1 hour at 0°C, the reaction medium is stirred at room temperature for 2 days. The dichloromethane phase is washed with water, dried over sodium sulfate, filtered and evaporated under vacuum. The residue obtained is triturated from a heptane/ethyl acetate mixture, filtered and evaporated. 5.6 g (60%) of 5-bromothiophene-N-methyl-3-carboxylamide are obtained. (e) (5-Bromothiophen-3-ylmethyl)methylamine A solution of 9 ml {18 mmol) of 2H dimethyl sulfide borohydride in toluene is added dropwise to a suspension of 3.7 g (17 mmol) of 5-bromothiophene-N-raethyl-3-carboxylamide in 50 ml of toluene, cooled beforehand to -78°C. After addition, the reaction medium is stirred from -78°C to room temperature over 16 hours and then refluxed for 5 hours. Aqueous 10% sodium carbonate solution is added to the reaction medium, and the medium is extracted with dichloro-methane. After acid-base washing, the organic phase is dried over magnesium sulfate, filtered and concentrated under vacuum. 2.3 g (66%) of (5-bromothiophen-3-ylmethyl)methylamine are obtained. (f) N- (5-Bromothiophen-3-ylmethyl) -N-methylbenzamide 1.6 ml {13 mmol) of benzoyl chloride are added dropwise to a solution of 2.3 g (11 mmol) of {5~bromothiophen-3-ylmethyl)methylamine and 3 ml (22 mmol) of triethylamine in 30 ml of tetrahydrofuran. The reaction medium is stirred at room temperature for 1 hour, filtered, diluted with ethyl acetate and washed with water. The organic phase obtained is dried over sodium sulfate, filtered and evaporated to dryness. The residue obtained is purified by chromatography on a column of silica eluted with an 8/2 heptane/ethyl acetate mixture. 3.1 g (80%) of N- (5-broraothiophen-3-ylmethyl)-N-methylbenzamide are obtained. (g) N-[5-(4-formylphenyl)thiophen-3-ylmethyl]-N-methyl-benzamide In a manner similar to that of Example l(c), starting with 3 g (10 mmol) of N-(5-bromothiophen-3-ylmethyl)-W-methylbenzamide and 1.9 g (13 mmol) of 4-formylbenzeneboronic acid, 2.6 g (80%) of W-[5-(4-formylphenyl)thiophen-3-ylmethyl]-N-methylbenzamide are obtained after purification by chromatography on a column of silica eluted with a 7/3 heptane/ethyl acetate mixture. (h) N-{5-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-phenyl]thiophen-3-ylmethyl}-N-methylbenzamide In a manner similar to that of Example l(d), starting with 2.6 g (8 mmol) of N-[5-{4-formylphenyl)-thiophen-3-ylmethyl]-N-methylbenzamide and 1 g (8.5 mmol) of 2,4-thiazolidinedione, 2.2 g (63%) of N-{5-[4-(2,4-dioxothiazolidln-5-ylidenemethyl)phenyl]-thiophen-3-ylmethyl}-N-methylbenzamide are obtained. {i) N-{5-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenyl]-thiophen-3-ylmethyl} -N-methylbenzamide In a manner similar to that of Example l(e), by hydrogenation of 1.8 g (4.2 mmol) of N-{5-[4-(2,4- dioxothiazolidin-5-ylidenemethyl)phenyl]thiophen-3-ylmethyl}-N-methylbenzamide, 800 mg (45%) of N-{5-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenyl3thiophen-3-ylmethyl}-N-methylbenzamide are obtained in the form of a solid with a melting point of 153°C. 1H NMR (δ, CDC13): 2.93-3.10 (m, 3H) ; 3.15 (dd, J-22 Hz, J = 7 Hz, 1H); 3.51 (dd, J - 6.1 Hz, J = 22 Hz, 1H); 4.49 (dd, J = 6.1 Hz, J = 15 Hz, 1H); 4.63-4.89 (m, 2H); 7.02-7.69 (m, 11H); 9.36 (s, 1H). Example 3: N-{5-[4-(2,4-Dioxothiazolidin-5-yl»*thyl)-phonyl]pyrid-3-ylmothyl}-N-mathylb«nza»id« (a) Ethyl 5-bromonicotinate 20 ml (27 mmol) of thionyl chloride are added dropwise, at room temperature, to a solution of 10 g (49 ramol) of 5-bromonicotinic acid in 250 ml of ethanol. The reaction medium is stirred at room temperature for 4 days and then evaporated under vacuum. The residue is taken up in dichloromethane and washed with aqueous sodium carbonate solution. The organic phase is dried over sodium sulfate, filtered and evaporated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 7/3 heptane/ethyl acetate mixture. 9 g (82%) of ethyl 5-bromonicotinate are obtained. (b) (5-Bromopyrid-3-yl)methanol A solution of 9 g (40 mmol) of ethyl 5-bromo- nicotinate in 25 ml of methanol is added dropwise, at room temperature, to a suspension of 14.8 g (400 mmol) of sodium borohydride in 75 ml of methanol. After addition, the reaction medium is refluxed for 2 hours. The reaction medium is evaporated to dryness, taken up in aqueous sodium hydroxide solution to pH 9, and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and evaporated under vacuum. 3.7 g (50%) of (5-bromopyrid-3-yl)-methanol are obtained. (c) 5-Bromopyridine-3-carbaldehyde 4.5 g (21 mmol) of pyridinium chlorochromate are added at room temperature to a solution of 3 g (16 mmol) of (5-bromopyrid-3-yl)methanol in 70 ml of dichloromethane. After stirring for 1 hour, 70 ml of diethyl ether are added and the reaction medium is again stirred for 1 hour. The precipitate is filtered off through sodium sulfate and the filtrate is evaporated to dryness. The residue obtained is purified by chromatography on a column of silica eluted with a 7/3 heptane/ethyl acetate mixture. 1 g (35%) of 5-bromopyridine-3-carbaldehyde is obtained. (d) (5-Bromopyrid-3-ylmethyl)methylamine 1.8 g (27 mmol) of methylamine hydrochloride and then 0.4 g (6 mmol) of sodium cyanoborohydride are successively added to a solution of 1 g (5.4 mmol) of 5-bromopyridins-3-carbaldehyde in 20 ml of methanol. The reaction medium is stirred at room temperature for 2 days. The precipitate is filtered off and the filtrate is evaporated to dryness. The residue is taken up in dichloromethane and washed with water. After extraction, the organic phase obtained is washed with aqueous hydrochloric acid solution. The aqueous phase thus obtained is brought to pH 9 with aqueous sodium hydroxide solution and then extracted with dichloromethane. The organic phase thus obtained is dried over magnesium sulfate, filtered and concentrated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 9.5/0.5 dichloromethane/methanol mixture. 0.5 g (50%) of (5-bromopyrid-3-ylmethyl)methylamine is obtained. (e) N- (5-Bromopyrid-3-ylmethyl) -N-methylbenzamide In a manner similar to that of Example 2(f), starting with 0.5 g (3 mmol) of (5-bromopyrid-3-ylmethyl)methylaniine and 0,4 ml (3.6 mmol) of benzoyl chloride, .0 . 8 g (90%) of N- (5-bromopyrid~3-ylmethyl) -W-methylbenzamide i's obtained. (f) N-[5-{4-Formylphenyl)pyrid-3-ylmethyl]-N-meth.yl- benzamide In a manner similar to that of Example l{c), starting with- 0.8 g (2.6 mmol) of N-[5-{4-formyl-phenyl)pyrid-3-ylmethyl)-N-methylbenzamide and 0.5 g (3.15 mmol) of 4-formylbenzeneboronic acid, 0.8 g (93%) of N- [5-(4-formylphenyl)pyrid-3-ylmethyl]-N-methyl-benzamide is obtained after purification on a column of silica eluted with a 7/3 heptane/ethyl acetate mixture. (g) N-{5-[4- (2,4-Dioxothiazolidin-5-ylidenemethyl)-phenyl] pyrid-3-ylmethyl }-N--methylbenzamide In a manner similar to that of Example 1(d) starting with 0.8 g (2.4 mmol) of N-[5-(4-formylphenyl ) pyrid-3-ylmethyl]-N-methylbenzamide and 0.35 g (2.9 mmol) of 2,4-thiazolidinedione, 0.6 g (60%) of N-{5-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)phenyl]-pyrid-3-ylmethyl}-N-methylbenzamide ia obtained. (h) W-{5-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenyl]-pyrid-3-ylmethyl}-N-methylbenzamide In a manner similar to that of Example l{e), by hydrogenation of 0,6 g (1.4 mmol) of N-{5- [4-(2,4-Dioxothiazolidin-5-ylidenemethyl)phenyl]pyrid-3-ylmethyl}-N-methylbenzamide, 0.2 g (33%) of W-{5-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenyl]pyrid-3-ylmethyl}-N-methylbenzamide is obtained in the form of a solid with a melting point of 92°C. 1H NMR (δ, CDC13) : 2.96-3.10 (m, 3H); 3.20 (dd, J - 22 Hz, J =7 Hz, 1H); 3.58 (dd, J - 6.1 Hz, J = 22 Hz, 1H); 4.55 (dd, J = 6.1 Hz, J - 15 Hzr 1H); 4.573-4.84 (m, 2H); 7.30-8.60 (m, 12H); 8.79 (s, 1H). Example 4: N- {3- [5- (2,4-dioxothiaiolid±n-5-ylmethyl) - "-pyrid-2 -yl ] benzyl} -N-methylootanoylamide (a) Ethyl 6-(3-formylphenyl)nicotinate In a manner similar to that of Example l(c), starting with 26.3 g (95 mmol) of ethyl 6-iodo-nicotinate and 18.5 g (123 mmol) of 4-formylbenzene-boronic acid, 6 g (27%) of ethyl 6-(3-formylphenyl)-nicotinate are obtained after chromatography on a column of silica eluted with a 7/3 heptane/ethyl acetate mixture. (b) Ethyl 6-(3-methylaminomethylphenyl)nicotinate In a manner similar to that of Example 3(d), starting with 6.2 g {25.5 mmol) of ethyl 6-(3-formylphenyl) nicotinate and 8.6 g (127.5 mmol) of methylamine hydrochloride, 2.7 g (40%) of ethyl 6-(3-methylaminomethylphenyl) nicotinate are obtained after purification by chromatography on a column of silica eluted with a 95/5/0.5 dichloromethane/methanol/isopropylamine mixture. (c) Ethyl 6-{3-[(methyloctanoylamino)methyl]phenyl}- nicotinate In a manner similar to that of Example l(b), starting with 2.1 g (7.8 mmol) of ethyl 6-(3-methylaminomethylphenyl) nicotinate and 1.3 g (8 mmol) of octanoyl chloride, 2.9 g (100%) of ethyl 6-{3-[(methyl- octanoylamino)methyl]phenyl}nicotinate are obtained after purification by chromatography on a column of silica eluted with a 6/4 heptane/ethyl acetate mixture. (d) N- [3- (5-Hydroxymethylpyrid-2-yl) benzyl] -JW-methyl- octanoylamide 0.8 g (35 mmol} of lithium borohydride is added slowly to a solution of 3.3 g (9 mmol) of ethyl 6-{3-[(methyloctanoylamino)methyl]phenyl}nicotinate in 35 ml of tetrahydrofuran, cooled beforehand to 0°C. The reaction medium is stirred from 0°C to room temperature over 24 hours and then poured into a water + ice mixture and extracted with ethyl acetate. The organic phase is dried over sodium sulfate, filtered and concentrated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with an 8/2 heptane/ethyl acetate mixture. 1.9 g (61%) of W-[3-(5-hydroxymethyl-pyrid-2-yl)benzyl]-W-methyloctanoylamide are obtained. (e) N- [3-(5-Formylpyrid-2-yl)benzyl]-N-methyloctanoyl- amide 5.5 g (63 mmol) of manganese dioxide are placed in a solution of 2.25 g (6.3 mmol) of W-[3-{5-hydroxymethylpyrid-2-yl)benzyl]-W-methyloctanoylamide in 50 ml of dichloromethane. After stirring at room temperature for 16 hours, the reaction medium is filtered through Celite, the precipitate is washed thoroughly with dichloromethane and the filtrate is concentrated under vacuum. 1.7 g (78%) of W-[3-(5-formylpyrid-2-yl)benzyl]-W-methyloctanoylamide are obtained, (£) N-{3-[5-(2,4-Dioxothiazolidin-5-ylidenemethyl)-pyrid-2-yl]benzyl}-N-methyloctanoylamide In a manner similar to that of Example l(d)f starting with 1.7 g (4.8 mmol) of W-[3-(5-formylpyrid-2-yl} benzyl]-W-methyloctanoylamide and 0.6 g (4.8 mmol) of 2,4-thiazolidinedione, 1.4 g (62%) of N-{3- [5- (2,4-dioxothiazolldin-5-ylidenemethyl)pyrid-2-yl]benzyl}-N-methyloctanoylamide are obtained after purification by chromatography on a column of silica eluted with a 4/6 heptane/ethyl acetate mixture. (g) N-(3-[5-(2,4-dioxothiazolidin-5-ylmethyl)pyrid-2-yl]benzyl}-N-methyloctanoylamide In a manner similar to that of Example 1(e), by hydrogenation of 400 mg (0.9 mmol) of N-{3-[5- (2,4-dioxothiazolidin-5-ylidenemethyl)pyrid-2-yl]benzyl}-N-methyloctanoylamide, 210 mg (53%) of N-{3-[5-{2f4-dioxothiazolidin-5-ylmethyl)pyrid-2-yl]benzyl}-N-methyloctanoylamide are obtained after purification on a column of silica eluted with a 3/7 heptane/ethyl acetate mixture. 1H NMR (δ, CDC13) : 0.84 (t, J = 7 Hz, 3H) ; 1.21-1.35 (m, 8H); 1.69 (m, 2H); 2.40 (t, J = 7.7 Hz, 2H); 2.97 (s, 3H); 3.30 (dd, J = 22 Hz, J = 7 Hz/ 1H); 3.48 (dd, J - 6.1 Hz, J = 22 Hz, 1H); 4.57 (dd, J = 6.1 Hz, J = 15 Hz, 1H); 4.57 3-4.68 (m, 2H) ; 7.20-7.86 (m, 7H); 8.57 (s, 1H) . Example 5: 2 (S) Ethoxy-3-{4-{5-[ (mathyloctanoylamino)-nmthyl] thiophon-3-yl}phenyl) propanoic acid (a) (4-Bromothiophen-2-yliaethyl) me thylamine In a manner similar to that of Example 3(d), starting with 4.7 g (24.6 mmol) of 4-bromothiophene-2-carbaldehyde and 8.3 g (123 mmol) of methylamine hydrochloride, 1.7 g (33%) of (4-bromothiophen-2-yl-methyl)methylamine are obtained after purification by chromatography on a column of silica eluted with an 8/2 heptane/ethyl acetate mixture. (b) N-(4-Bromothiophen-2-ylmethyl)-N-methyloctanoyl- amide In a manner similar to that of Example 1(b), starting with 1.7 g (8.25 mmol) of (4-bromothiophen-2-ylmethyl)methylamine and 1.6 ml (9 mmol) of octanoyl chloride, 2.1 g (80%) of N- (4-bromothiophen-2-yl-methyl)N-methyloctanoylamide are obtained after purification on a column of silica eluted with an 8/2 heptane/ethyl acetate mixture. (c) N-[4-(4-formylphenyl)thiophen-2-ylmethyll-N-methyl- octanoylamide In a manner similar to that of Example l(c), starting with 2.1 g (6.3 mmol) of N-(4-bromothiophen-2-ylmethyl)-N-methyloctanoylamide and 1.1 g (7.6 mmol) of 4-formylbenzeneboronic acid, 1.4 g (61%) of N-[4-(4-formylphenyl)thiophen-2-ylmethyl]-N-methyloctanoylamide are obtained after purification by chromatography on a column of silica eluted with a 7/3 heptane/ethyl acetate mixture. (d) N- (4-{4-[3-(4-benzyl-2-oxooxazolidin-3-yl)-2 (S)- ethoxy-1(S)-hydroxy-3-oxopropyl]phenyl}thiophen-2-yl- methyl)-N-methyloctanoylamide - Preparation of 4 (S)-benzyl-3-(2-ethoxyacetyl)- oxazolidin-2-one: 93 ml (232 mmol) of butyllithium are added dropwise to a solution of 41 g (232 mmol) of S-(-)-4-benzyloxazolidin-2-one in 600 ml of tetrahydrofuran cooled beforehand to -78°C. After stirring for 30 minutes, 35 g (279 mmol) of ethoxyacetyl chloride are added dropwise. After stirring for 1 hour at -78°C, the reaction medium is stirred at room temperature for 18 hours. The reaction medium is evaporated to dryness, taken up in ethyl acetate and washed with water. The organic phase is dried over sodium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with an 8/2 heptane/ethyl acetate mixture. 54 g (90%) of 4(S)-benzyl-3-(2-ethoxyacetyl)oxazolidin-2-one are obtained. - Preparation of N-(4-{4-[3-(4-benzyl-2-oxooxazolidin-3-yl)-2(3)-ethoxy-1(S)-hydroxy-3-oxopropyl]phenyl}-ithiophen-2-ylmethyl)-N-methyloctanoylamide 5.9 ml (5.9 mmol) of dibutylboron triflate are added dropwise to a solution of 1.2 g (4.7 mmol) of 4(S)-benzyl-3-(2-ethoxyacetyl)oxazolidin-2-one in 20 ml of dichloromethane, cooled beforehand to 0°C, followed by addition of 1 ml (5.9 mmol) of diisopropyl-ethylamine. The reaction medium is stirred at 0°C for 30 minutes and then cooled to -78°C and 1.4 g (3.9 mmol} of N-[4-(4-formylphenyl)thiophen-2-ylmethyl]-N-methyloctanoylamide in 15 ml of dichloromethane are added dropwiae. Stirring is continued at -78°C for 1 hour and then at room temperature for 2 hours 30 minutes. The reaction medium is cooled to 0"C and 11 ml of a pH 7 buffer solution in 11 ml of methanol are added, followed by addition of 11 ml of 30% aqueous hydrogen peroxide solution in 11 ml of methanol. After stirring at 0°C for 1 hour 30 minutes, water is added and the reaction medium is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography through a column of silica eluted with a 6/4 heptane/ethyl acetate mixture. 1.8 g (75%) of N-(4-{4-[3-(4-benzyl-2-oxooxazolidin-3-yl)-2-ethoxy-l-hydroxy- 3-oxopropyl]phenyl}thiophen-2-ylmethyl)-N-methyloctanoylamide are obtained. (e) {4-{4-[3-(4-Benzyl-2-oxooxazolidin-3-yl)-2(S)- ethoxy-3-oxopropyl]phenyl)th±ophen-2-ylmethyl)methyl-octanoylamide 0.9 ml (1.6 mmol} of sodium bis(trimethyl-silyl)amide is added to a solution of 1 g {1.6 iranol) of W-(4~(4-[3-(4-benzyl-2-oxooxazolidin-3-yl)-2-ethoxy-l-hydroxy-3-oxopropyl]pheny1}thiophen-2-ylmethyl)-N-methyloctanoylamide in 20 ml of dichloromethane, cooled beforehand to -78°C. After stirring at -78°C for 1 hour, 0.25 ml (1.8 mmol) of phenyl chlorothionoformate is added and the reaction medium is stirred at -78°C for 1 hour and then at room temperature for 2 hours. After adding water, the reaction medium is extracted with dichloromethane. The organic phase is evaporated under vacuum. The residue obtained is placed in 30 ml of toluene, and 13 mg (0.1 mmol) of 2,2'-azobis(2-methylpropionitrile) and 0.65 ml (2.4 mmol) of tributyltin hydride are then added. The reaction medium is heated at 110°C for 30 minutes. The reaction medium is cooled, diluted with ethyl acetate and washed with water. The organic phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a 6/4 heptane/ethyl acetate mixture. 0.65 g (65%) of (4-{4- [3-(4-benzyl-2-oxooxazolidin-3-yl)-2-ethoxy-3-oxopropyl]phenyl}thiophen-2-ylmethyl)methyl-octanoylamide is obtained. (f) 2(S)-Ethoxy-3-(4-{5-[{methyloctanoylamino)methyl ]-thiophen-3-yl}phenyl)propanoic acid 1.3 ml (1.6 mmol) of aqueous 0.5 N lithium hydroxide solution are added to a solution of 0.6 g (1 mmol) of (4-{4-[3-(4-benzyl-2-oxooxazolidin-3-yl)-2-ethoxy-3-oxopropyl]phenyl}thiophen-2-ylmethyl) methyl-octanoylamide in 10 ml of tetrahydrofuran, cooled to OeC. After stirring at 0°C for 30 minutes, the reaction medium is stirred at room temperature for 1 hour 30 minutes. Water and ethyl acetate are added to the reaction medium, and an aqueous sodium hydroxide solution is then added until pH 8-9 is obtained. After extraction and separation of the phases, repeated twice, the product is in the aqueous phase. This aqueous phase is acidified to pH 3-4 with aqueous IN hydrochloric acid solution, extracted with ethyl acetate, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a 98/2 dichloromethane/methanol mixture. 0.35 g (76%) of 2(S)-ethoxy-3-(4-{5-[(methyloctanoylamino) methyl]thiophen-3-yl}phenyl)propanoic acid is obtained. 1H NMR (δ, CDCl3) : 0.89 (m, 3H) ; 1.19 (t, J = 6.8 Hz, 3H); 1.30-1.34 (m, 8H); 1.69 (m, 2H); 2.36-2.50 (m, 2H) ; 3.-03 (s, 3H); 3.06 (m, 1H); 3.15 {dd, J = 4.0 Hz, J= 14.0 Hz, 1H); 3.41-3.45 (m, 1H); 4.09-4.12 (m, 1H) ; 4.10 (dd, J = 4.0 Hz, J - 7.0 Hz, 1H); 4.69-4.74 (m, 2H); 7,19-7.35 (m, 4H); 7.49 (d, J = 7.9 Hz, 2H). Example 6: 2 (S)-Ethoxy-3-(4-{5-[ (mathyloctanoylamino)-methyl]thiophen-2-yl}ph«nyl)propanoic aaid a- (5-Bromothiophen-2-ylmethyl)-AHnethylamine 14 g (209 mmol) of methylamine hydrochloride are added to a solution of 5 g {42 iranol) of 5-bromo-thiophene-2-carboxaldehyde in 80 ml of ethanol and 40 ml of methanol. The reaction medium is cooled to O'C and 5.8 g (83.8 mmol) of sodium cyanoborohydride are added. The reaction medium is stirred at 0°C for 5 hours, hydrolysed and diluted with ethyl acetate. The organic phase is washed with water, dried over magnesium sulfate, filtered and evaporated. The residue obtained is taken up in a 70/30 'heptane/dichloromethane mixture and then filtered. 6.7 g of crude residue are obtained. b- (5-Bromothiophen-2-ylmethyl)-W-methyloctanoylamide 6.2 ml (35.7 mmol} of octanoyl chloride are added dropwise to a solution of 6.7 g (32.5 mmol) of crude residual (5-bromothiophen-2-ylmethyl)-W-methyl-amine obtained in 6a, in 120 ml of tetrahydrofuran and 5 ml {35.7 mmol) of triethylamine, cooled beforehand to 0°C. The reaction medium is stirred for 30 minutes at 0°C and then for 4 hours at room temperature. After addition of water, the reaction medium is extracted with ethyl acetate. The organic phase is washed with aqueous sodium chloride solution, isolated and then evaporated. The residue obtained is purified by chromatography on a column of silica eluted with an 8/2 and then 7/3 heptane/ethyl acetate mixture. 1.2 g (11%) of (5-bromothiophen-2-ylmethyl}-W-methyloctanoylamide are obtained. c- [5- (4-Formylphenyl) thiophen-2-ylmethyl] -W-methyl-octanoylamide 5.4 ml (10.8 mmol} of aqueous potassium carbonate solution are added to a solution of 1.2 g (3.6mmol) of (5-bromothiophen-2-ylmethyl)-W-methyl-octanoylamide and 0.65 g (4.3 mmol) of 4-formylbenzene-boronic acid in 20 ml of toluene. The reaction medium is degassed and 0.12 g (0.1 mmol) of tetrakis(triphenylphoaphine)palladium is then added. The reaction medium is stirred at 90°C for 5 hours. After addition of water, the reaction medium is extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with an 8/2 and then 7/3 heptane/ethyl acetate mixture. 0.25 g (19%) of [5-{4-formylphenyl)thiophen-2-ylmethyl]-N-methyloctanoylamide is obtained. d- N-(5-{4-[3-(4 (S)-benzyl-2-oxooxazolidin-3-yl)-2(S)-ethoxy-1 (S) -hydroxy-3-oxopropyl]phenyl}thiophen-2-yl-methyl)-W-methyloctanoylamide 2.26 ml (2.26 mmol) of a solution of dibutyl-borane trlflate are added dropwise to a solution of 0.48 g (1.8 mmol) of [5-{4-formylphenyl)thiophen-2-ylmethyl]-N-methyloctanoylamide in 12 ml of dichloro-methane, cooled to 0°C, followed by addition of 0.39 ml (2.26 mmol) of diisopropylethylamine. The reaction medium is stirred at 0°C for 30 minutes and then cooled to -78°C. A solution of 0.54 g (1.5 mmol) of 4{S)-benzyl-3-(2-ethoxyacetyl)oxazolidin-2-one (prepared as described in Example 5d) in 5 ml of dichloromethane is added dropwise. The reaction medium is stirred at -78°C for 1 hour and then at room temperature for 2 hours 30 minutes. After cooling to 0°C, a mixture of 4 ml of a pH 7 buffer solution and 4 ml of methanol is added dropwiae, followed by dropwise addition of a mixture of 4 ml of aqueous 30% hydrogen peroxide solution and 4 ml of methanol. The reaction medium is stirred for 1 hour at room temperature, water is added and the medium is extracted with dichloromethane. The dichloromethane phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a 7/3 and then 6/4 heptane/ethyl acetate mixture. 0.62 g (66%) of N-(5-{4-[3-(4(S)-benzyl-2-oxooxazolidin-3-yl)- 2(S)-ethoxy-l(S)-hydroxy-3-oxopropyl]phenyl}thiophen-2-ylmethyl}-N-methyloctanoylamide is obtained. e- 0-[3-(4(S)-Benzyl-2-oxooxazolidin-3-yl)-2(S)-ethoxy-1- (4-{5-[ (methyloctanoylamino)methyl]thiophen-2-yl}phenyl)-3-oxopropyl] 0-phenyl thiocarbonate 0.55 ml (1.1 nunol) of sodium trimethylsilyl-amide is added to a solution of 0.62 g (1 mmol) of N-(5-{4-[3-(4(S)-benzyl-2-oxooxazolidin-3-yl)-2(S)-ethoxy-1(S)-hydroxy-3-oxopropyl]phenyl}thiophen-2-yl-methyl)- N-methyloctanoylamide in 15 ml of tetrahydro-furan, cooled beforehand to -78°C, and the reaction medium is stirred for 1 hour at -78°C, followed by addition of 0.15 ml (1.1 mmol) of phenyl chlorothiono-formate. The reaction medium is again stirred at -78 °C for 1 hour and then at room temperature for 1 hour. After addition of water, the reaction medium is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated. The crude product is used in step f. f- (5-{4-[3-(4(S)-benzyl-2-oxooxazolidin-3-yl)-2(S)-ethoxy-3-oxopropyl]phenyl}thiophen-2-ylmethyl)-N-methyloctanoylamide The crude product obtained from step e is placed in 15 ml of toluene with 0.01 g (0.05 mmol) of AiBN and 0.4 ml (1.5 mmol) of tributyltin hydride. After heating at 110°C for 45 minutes, the reaction has not changed. 0.56 ml (2.1 rnmol) of tributyltin hydride is added and the reaction medium is stirred at 110°C for 2 hours. Water is added and the reaction medium is extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with an 8/2 and then 7/3 heptane/ethyl acetate mixture. 0.27 g (45%) of (5-{4-[3-(4(S)-benzyl-2-oxooxazolidin-3-yl)-2(S)-ethoxy-3-oxopropyl]phenyl}thiophen-2-ylmethyl)-N-methyl-octanoylamide is obtained. g- 2(S)-Ethoxy-3-(4-{5-[(methyloctanoylamino)methyl]-thiophen-2-yl}phenyl)propanoic acid A solution of 0.27 g {0.45 mmol) of (5-{4-[3-(4(S)-benzyl-2-oxooxazolidin-3-yl)-2(S)-ethoxy-3-oxopropyl]phenyl}thiophen-2-ylmethyl)-N-methyloctanoyl-amide in 10 ml of tetrahydrofuran and 1.3 ml (0.67 mmol) of aqueous 0.5M sodium hydroxide solution is stirred from 0°C to room temperature over 18 hours. After addition of water, a first extraction is performed with ethyl acetate. The aqueous phase obtained is acidified to pH 6 with aqueous hydrochloric acid solution and then extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a 5/5 heptane/ethyl .acetate mixture. 0.06 g (30%) of 2(S)-ethoxy-3-(4-{5-[(methyloctanoyl-amino)methyl]thiophen-2-yl}phenyl)propanoic acid is obtained. 1H NMR (δ CDC13): 0.88 {t, J - 6.7 Hz, 3H); 1.18 (t, J- 7.0 Hz, 3H); 1.28-1.35 (m, 8H) ; 1.67-1.70 {m, 2H) ; 2.34-2.48 (m, 2H); 3.00 (m, 1H); 3.01 (s, 3H); 3.14 (m, 1H); 3.47 (m, 1H); 3.63 (m, 1H); 4.11 (m, 1H); 4.69 (m, 2H}; 6.90 (dd, J - 17 Hz, J - 3.6 Hz, 1H); 7.14 (dd, J - 3.6 Hz, J = 13 Hz, 1H); 7.27 (d, J = 8.1 Hz, 2H) ; 7.50 (d, J = 8.1 Hz, 2H). Example 7: 2 (S)-Ethoxy-3-{4-[2-(3-h«ptyl-l-methyl-ureldo) thiazol-5-yl]phenyl}propanoic acid a- N-(5-Bromothiazol-2-yl)acetamide 5.9 ml {42.3 mmol) of acetic anhydride are added to a solution of 10 g (38.5 mmol) of 2-amino-5-bromothiazole hydrobromide in 100 ml of dichloromethane and 11 ml (77 mmol) of triethylamine, cooled to 0°C. The reaction medium is stirred for 30 minutes at 0°C and then for 18 hours at room temperature. After addition of water, the pH is adjusted to pH 8 with aqueous 1M sodium hydroxide solution and the reaction medium is extracted with dichloromethane. The dichloromethane phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is used in step b without purification. b- N-(5-Bromothiazol-2-yl)-N-methylacetamide 1.9 g {14 nunol) of potassium carbonate and 3.94 ml (63.3 mmol) of methyl iodide are added to a solution of 2.8 g {12.7 mmol) of N~(5~broraothiazol-2-yl)acetamide in 50 ml of acetone. The reaction medium is refluxed for 3 hours. After addition of water, the reaction medium is extracted with ethyl acetate. The organic phase is washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a 7/3 heptane/ethyl acetate mixture. 1.1 g (36%) of N- (5-Bromothiazol-2-yl)-N-methylacetamide are obtained. c- Methyl 3-{4-bromophenyl)-2(S)-hydroxypropanoate 100 ml (170 mmol) of a 1.7 M solution of tert-butyllithium in pentane are added dropwise to a solution of 48 g {204 mmol) of 1,4-dibromobenzene in 160 ml of tert-butyl dimethyl ether, cooled to -30°C, followed by addition of 7.3 g (82 mmol) of copper cyanide. The reaction medium is stirred for 15 minutes and a solution of 6 ml {68 mmol) of (S)-methyl glycidate in 10 ml of tert-tautyl dimethyl ether is then added. After stirring for 20 minutes at -30°C, the reaction medium is hydrolysed with 150 ml of saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The organic phase is washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with heptane, and the' polarity is then increased up to a 6/4 heptane/ethyl acetate mixture. 23.5 g (44%) of methyl 3-{4-bromophenyl}-2(S)-hydroxypropanoate are obtained. d- Methyl 3-(4-bromophenyl)-2(S)-ethoxypropanoate 11 ml of ethyl iodide are added dropwise to a solution of 23.5 g (91 mmol) of methyl 3-(4-bromophenyl)-2(S)-hydroxypropanoate and 35.6 g (155 mmol) of silver(I) oxide in 120 ml of iaopropyl ether. The reaction medium is heated at 70°C overnight. 10 g {45 mmol) of silver oxide and 3.7 ml (45 mmol) of ethyl iodide are added and the reaction medium is heated for a further 4 hours and then filtered through Celite, the precipitate is rinsed with ethyl acetate and the filtrate is concentrated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 95/5 and then 90/10 heptane/ethyl acetate mixture. 20 g (79%) of methyl 3-(4-bromophenyl)-2(S)-ethoxypropanoate are obtained. e- Methyl 2(S)-ethoxy-3-[4-{4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]propanoate A solution of 8.3 g (28.9 mraol) of methyl 3-(4-bromophenyl)-2{S)-ethoxypropanoate, 11 g (43.3 mmol) of bis-pinacoldiborane and 8.5 g (86.7 mmol) of potassium acetate in 250 ml of dimethylformamide is degassed for 15 minutes, and 0.94 g (1.2 mmol) of diphenylphoaphinoferrocenepalladium chloride (PdCl2dppf) is then added. The reaction medium is heated at 60°C for 20 hours. After cooling, water is added and the reaction medium is extracted with ethyl acetate. The ethyl acetate phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a 95/5 and then 90/10 heptane/ethyl acetate mixture. 7 g (73%) of methyl 2 (S)-ethoxy-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]propanoate are obtained. f- Methyl 3-{4-[2-{acetylmethylamino)thiazol-5-yl]-phenyl}-2 (S)-ethoxypropanoate 0.2 g (0.3 mmol) of diphenylphosphino-ferrocenepalladium chloride (PdCl2dppf) is added to a solution of 1 g (4.5 mmol) of N- (5-bromothiazol-2-yl)-tf~methylacetamide, 1.8 g (6.8 mmol) of methyl 2(S)-ethoxy-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]propanoate and 1 g (6.8 mmol) of caesium fluoride in 50 ml of ethylene glycol dimethyl ether, degassed beforehand. The reaction medium is heated at 80°C for 18 hours. After cooling, water is added and the reaction medium is extracted with ethyl acetate. The ethyl acetate phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a 70/30 and then 60/40 heptane/ethyl acetate mixture. 0.6 g (37%) of methyl 3-{4-[2-(acetylmethyl-amino)thiazol-5~yl]phenyl}-2(S)-ethoxypropanoate is obtained in the form of a beige-coloured solid with a melting point of 123°C. g- 2(S) -Ethoxy-3-[4-(2-methylaminothiazol-5-yl)phenyl]-propanoic acid 0.6 g (1.6 mmol) of methyl 3-{4-[2- (acetyl-methylamino)thiazol-5-yl]phenyl}-2(S)-ethoxypropanoate in 25 ml of methanol and 2.4 ml (2.4 mmol) of aqueous 1M sodium hydroxide solution are heated at 60°C for 18 hours. The reaction medium is cooled, diluted with water, acidified to pH 4-5 and then extracted with ethyl acetate and n-butanol. The organic phase is washed with saturated sodium chloride solution, dried over magnesium aulfate, filtered and evaporated. The residue obtained is used in step h without purification. h- Methyl 2 (S) -ethoxy-3- ['4- (2-methylaminothiazol-5-yl)phenyl]propanoate 0,5 g (1.6 mmol) of 2(S)-ethoxy-3-[4-(2-methylaminothiazol-5-yl)phenyl]propanoic acid in 10 ml of methanol and a few drops of sulfuric acid is heated at 60°C for 2 hours. The reaction medium is cooled, diluted with water, neutralized to pH 7 with aqueous 1M sodium hydroxide solution and then extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a 50/50 heptane/ethyl acetate mixture. 0.34 g (67%) of methyl 2(S)-ethoxy-3-[4-(2-methylaminothiazol-5-yl) phenyl]propanoate is obtained in the form of a yellow solid. i- Methyl 2(S)-ethoxy-3-{4-[2-(3-heptyl-l-methyl-ureido)thiazol-5-yl]phenylJpropanoate 0.17 ml (I mmol) of heptyl isocyanate is added to a solution of 0.17 g (0.5 mmol) of 2(S)-ethoxy-3-[4-(2-methylaminothiazol-5-yl)phenyl]-propanoate in 10 ml of dichloromethane. The reaction medium is stirred at room temperature for 20 hours. The reaction medium is diluted with water and then extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chrorciatography on silica eluted with a 50/50 heptane/ ethyl acetate mixture. 0.07 g (30%) of methyl 2{S)-ethoxy-3-{4-[2-(3-heptyl-l-methylureido)thiazol-5-yl]phenyl}propanoate is obtained. j- 2(S)-Ethoxy-3~{4-[2-(3-heptyl-l-methylureido)-thiazol-5-yl]phenyl}propanoic acid 0.07 g (0.15 mmol) of methyl 2(S)-ethoxy-3- {4- [2-(3-heptyl-l-methylureido)thiazol-5-yl]phenyl}-propanoate is placed in 3 ml of tetrahydrofuran and 0.2 ml (0.2 mmol) of aqueous 1M lithium hydroxide solution. The reaction medium is stirred at room temperature for 18 hours. 0.07 ml of aqueous 1M lithium hydroxide solution is added and the medium is heated for a further 5 hours. The reaction medium is diluted with water, acidified to pH 4-5 and then extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. 55 mg (82%) of 2 (S)-ethoxy-3-{4-[2-(3-heptyl-l-methylureido)-thiazol-5-yl]phenyl}propanoic acid are obtained in the form of a white solid with a melting point of 97°C. 1H NMR (δ CDC13) : 0.90 (t, J - 6.7 Hz, 3H); 1.22 (t, J = 7.0 Hz, 3H); 1.28-1.38 (m, 8H); 1.60 (m, 2H); 3.08 (dd, J » 7.5 Hzr J = 4.1 Hz, 1H); 3.15 (dd, J = 4.1 Hz, J = 14 Hz, 1H); 3.37 (m, 2H); 3.47 (s, 3H); 3.49 (m, 1H); 3.66 (m, 1H); 4.12 (m, 1H); 7.29 (d, J - 8.2 Hz, 2H); 7,43 (d, J - 8.2 Hz, 2H); 7.52 (s, 1H); 9.24 (s, Exampla 8: 2 (S)-Ethoxy-3M4-[2-(l-methyl-3-pentyl-uraido) thiazol-5-yllphenyl}propanoia acid a- Methyl 2(S)-ethoxy-3-{4-[2-(l-methyl-3-pentyl-ureido)thiazol-5-yl]phenyl}propanoate In a manner similar to that of Example 7i, starting with 0.17 g {0.53 mmol) of methyl 2(S)-ethoxy-3-[4-(2-methylaminothiazol-5-yl)phenyl]propionate and 0.14 ml (1.1 mmol) of pentyl isocyanate, 0.06 g (26%) of methyl 2(S)-ethoxy-3-{4-[2-(l-methyl-3-pentyl-ureido)thiazol-5-yl]phenyl}propanoate is obtained. b- 2(S)-Ethoxy-3-{4-[2-(l-methyl-3-pentylureido)-thiazol-5-yl]phenyl}propanoic acid In a manner similar to that of Example 7j, starting with 0.06 g (0.14 mmol} of methyl 2(S)-ethoxy-3-{4-[2- (l-methyl-3-pentylureido)thiazol-5-yl]phenyl}-propanoate and 0.2 ml (0.2 mmol) of aqueous 1M lithium hydroxide solution, 0.05 g (86%) of 2{S)-ethoxy-3-{4-[2-(l-methyl-3-pentylureido)thiazol-5-yl]phenyl}-propanoic acid is obtained in the form of a white solid with a melting point of 114°C. 1H NMR (δ CDC13) : 0.93 (t, J - 6.7 Hz, 3H) ; 1.22 (t, J - 7.0 Hz, 3H); 1.36-1.40 (m, 4H); 1.63 (m, 2H); 3.06 (dd, J = 7.5 Hz, J - 4.1 Hz, 1H); 3.15 (dd, J = 4.1 Hz, J - 14 Hz, 1H); 3.37 (m, 2H); 3.47 (s, 3H) ; 3.50 (m, 1H); 3.66 (m, 1H); 4.12 (m, 1H); 7.29 (d, J « 8.4 Hz, 2H); 7.43 (d, J= 8.4 Hz, 2H) ; 7.53 (B, 1H); 9.25 (a, 1H) . Example 9: 2 (8) -Ethoxy-3-{4-[6- (3-herptyl-l-methyl-ureido)pyrid-2-yl]phenyl}propanoic aoid a- tert-butyl (6-Bromopyrid-2-yl)carbamate 62 g (284 mmol) of di-tert-butyl dicarbonate diluted in 200 ml of dichloromethane are added dropwise to a solution of 49.2 g {284 mmol) of 2-amino-6-bromopyridine, 43.4 ml (312 mmol) of triethylaraine and 3.5 g {28.4 mmol) of 4-dimethylaminopyridine in 400 ml of dichloromethane. The reaction medium is stirred at room temperature for 18 hours. After addition of water and extraction with dichloromethane, the organic phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 95/5 heptane/ethyl acetate mixture. 39 g (50%) of tert-butyl (6-bromopyrid-2-yl)carbamate are obtained in the form of a white solid. b- tert-butyl 6-Broitiopyrid-2-yl-N-methylcarbamate 6.9 g (17.2 mmol) of 60% sodium hydride in oil are added portionwise to a solution of 39 g {14.3 mmol) of tert-butyl (6-bromopyrid-2-yl)carbamate in 400 ml of dimethylformamide. After stirring for 20 minutes at room temperature, 17.8 ml (28.6 mmol) of methyl iodide are added dropwise. The reaction medium is stirred at room temperature for 18 hours, taken up in water and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and evaporated. c- (6-Bromopyrid-2-yl)-N-methylamine 2.1 g (7.3 mmol) of tert-butyl 6-bromopyrid-2-yl-N-methylcarbamate, 1.6 ml (21.9 mmol) of trifluoroacetic acid and 25 ml of dichloromethane are stirred at room temperature for 20 hours. After addition of water, the reaction medium is extracted with dichloromethane. The organic phase is washed with aqueous sodium hydroxide so.lution and then washed with water, dried over magnesium sulfate, filtered and evaporated. 1.4 g (100%) of (6-bromopyrid-2-yl)-N-methylamine are obtained. d- 1-(6-Bromopyrid-2-yl)-3-heptyl-l-methylurea 1 g (5.35 mmol) of (6-bromopyrid-2-yl)-N-methylamine, 1 ml of diisopropylethylamine and 1.6 g (8 ramol) of 4-nitrophenyl chloroformate are heated at 130°C for 15 minutes by microwave. 1.2 ml (8 mmol) of heptylamine and 7 ml of dimethylformamide are added and the reaction medium is heated at 130°C for a further 5 minutes. The residue obtained is purified by thin-layer chromatography on silica eluted with a 70/30 heptane/ethyl acetate mixture. 1.4 g (80%) of l-(6-taromopyrid-2-yl)-3-heptyl-l-methylurea are obtained in the form of a yellow solid. e- Methyl 2(S)-ethoxy-3-{4-[6-(3-heptyl-l-methylureido) pyrid-2-yl]phenyl}propanoate 3.2 g (9.7 mmol} of 1-(6-bromopyrid-2-yl)-3-heptyl-1-methylurea, 4.2 g (12.6 mmol) of methyl 2(S)-ethoxy-3-[4-(4,4,5, 5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]propanoate (prepared as in Example 7e) and 4.4 g (29.1 mmol) of caesium fluoride are placed in 200 ml of dimethoxyethylene glycol. The reaction medium, is degassed, 0.23 g (0.3 mmol) of dichlorodiphenylphosphinoferrocenepalladium is then added and the reaction medium is stirred at 80°C for 18 hours. After addition of water, the reaction medium is extracted with ethyl acetate. The organic phase is washed with water, with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with an 80/20 heptane/ethyl acetate mixture. 2 g (45%) of methyl 2(S)-ethoxy-3-{4-[6-(3-heptyl-l-methylureido)pyrid-2-yljphenyl}propanoate are obtained. f- 2 (S)-Ethoxy-3-{4-[6-(3-heptyl-l-methylureido)pyrid-2-yl] phenyl }propanoic acid 1.1 g (2.4 mmol) of methyl 2(S)-ethoxy~3-{4-[6-(3-heptyl-l-methylureido)pyrid-2-yl]phenyl}-propanoate, 20 ml of tetrahydrofuran and 3.6 ml (3,6 mmol) of aqueous 1M lithium hydroxide solution are stirred at room temperature for 5 hours. After addition of water and ethyl acetate, the reaction medium is acidified to pH 5.5 with aqueous 1N acetic acid solution. The organic phase ig washed with water, dried over magnesium sulfate, filtered and evaporated. 1 g (95%) of 2'(S)-ethoxy-3-{4-[6-(3-heptyl~l~methylureido)-pyrid-2-yl}phenyl}propanoic acid is obtained in the form of a viscous syrup. 1H NMR (δ CDC13} : 0.87 (t, J = 6.7 Hz, 3H) ; 1.21 (t, J = 7.0 Hz, 3H); 1.26-1.37 (m, 8H); 1.61 (m, 2H) ; 3.10 (dd, J - 7.5 Hz, J •= 4.1 Hz, 1H) ; 3.21 (dd, J = 4.1 Hz, J = 14 Hz, 1H); 3.39 (m, 2H); 3.47 (a, 3H) ; 3.49 (m, 1H); 3.66 (m, 1H); 4.16 {m, 1H); 6.94 (d, J = 8.4 Hz, 1H); 7.28-7.40 (m, 3H); 7.75-7.82 (m, 3H) . Example 10: 2(8)-Ethoxy-3-{4-[6-(3-haptyl-l-methyl-ureido)pyrid-2-yl]phenyl)propanoio acid hydroohloride 2.5 ml (2.5 mmol) of ethanolic 1M hydrochloric acid solution are added dropwise to a solution of 1.1 g {2.5 mmol) of 2(S)-ethoxy-3-{4-[6-(3-heptyl-l-methylureido)pyrid-2-yl]phenyl}propanoic acid in 2 ml of ethanol, cooled to 0°C. The reaction medium precipitates. After filtration, the precipitate is washed with acetone and with ethyl ether and then dried. After hot recrystallization from a 9/1 acetone/ water mixture, 0.6 g (60%) of 2(S)-ethoxy-3-{4-[6-(3- heptyl-l-methylureido)pyrid-2-yl]phenyl}propanoic acid hydrochloride ia obtained in the form of a white solid with a melting point of 166 °C. 1H NMR {δ CDC13) : 0.77 (t, J- 6.7 Hz, 3H) ; 1.07 (t, J= 7.0 Hz, 3H) ; 1.10 - 1.25 (mr 8H) ; 1.58 (m, 2H) ; 3.00 (dd, J - 7.5 Hz, J - 4.1 Hz, 1H) ; 3.08 (dd, J- 4.1 Hz, J = 14 Hz, 1H); 3.26 (m, 2H) ; 3.27 (m, 1H) ; 3.60 (s, 3H) ; 3.61 (m, 1H) ; 3.96 {dd, J » 4.1 Hz, J = 8.4 Hz, 1H); 7.20 (m, 1H) ; 7.41 (d, J - B.I Hz, 2H); 7.44 {m, 1H) ; 7.66 (d, J - 8.1 Hz, 2H) ; 8.03 (ra, 1H) ; 9.00 (m, 2H) . Example 11: 2{S)-B1:hoxy-3-{4-t5-(3-h«ptyl-l-»ethyl-ureido) -2-nathyl-2H- [1,2,4] triazol-3-yl]phenyl) -peopanoic acid a- 5-Bromo-l-methyl-3-nitro-lH-[l,2,4;itriazole 1.1 g (28.5 mmol) of 60% sodium hydride are added to a solution of 5 g (25.9 mmol) of 5-bromo-3-nitro-lH-[l,2,4]triazole in 80 ml of dimethylformamide, cooled beforehand to 0°C. The reaction medium is stirred for 20 minutes and 8 ml (129.5 mmol) of methyl iodide are then added. After stirring at room temperature for 18 hours, water is added and the reaction medium is extracted with ethyl acetate. The organic phase is washed thoroughly with water, with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 75/25 heptane/ethyl acetate mixture. 3.2 g (60%) of 5-bromo-l-methyl-3-nitro-lH-[l,2,4]triazole are obtained. b- Methyl 2(S)-ethoxy-3-[4-(2-methyl-5-nitro-2H-[1,2,4]triazol-3-yl)phenyl]propanoate In a manner similar to that of Example 9(e), starting with 0.9 g (4.35 mmol) of 5-bromo-l-methyl-3-nitro-lH-[l,2,4]triazole and 1.9 g (6.5 mmol) of methyl 2 (S) -ethoxy-3- [4- (4, 4, 5,5-tetraraethyl [1,3,2] dioxa-borolan-2-yl)phenyl]propanoate, 0.9 g (62%) of methyl 2(S)-ethoxy-3-[4-(2-methyl-5-nitro-2H-[1,2,4]triazol-3-yl)phenyl]propanoate is obtained in the form of a white solid with a melting point of 119°C. c- Methyl 3-[4-(5-amino-2-methyl-2H-[l,2,4]triazol-3-yl)phenyl]-2(S)-ethoxypropanoate 0.4 g (0,4 mass equivalent) of 10% palladium-on-charcoal is added to a solution of 0,9 g (2.7 iranol) of methyl 2(S)-ethoxy-3-[4-(2-methyl-5-nitro-2H-[1,2,4]triazol-3-yl)phenyl]propanoate in 40 ml of ethanol and 10 ml of methanol, degassed beforehand, and the reaction medium is placed under an atmospheric pressure of hydrogen for 3 hours. After filtration through Celite and washing with ethyl acetate, the filtrate is evaporated under vacuum. 0.82 g (100%) of methyl 3-[4-(5-amino-2-methyl-2H-[1,2,4]triazol-3-yl)-phenyl]-2(S)-ethoxypropanoate is obtained. d- Methyl 2(S)-ethoxy-3-[4-{2-methyl-5-methylamino-2H-[1,2,4]triazol-3-yl)phenyl]propanoate 0.2 ml (2.2 mmol) of dimethyl sulfate is added to a mixture of 0.6 g (2 mmol) of methyl 3-[4-{5-amino-2-methyl-2H-[1,2,4]triazol-3-yl)phenyl]-2(S)-ethoxypropanoate, 0.3 ml {2.2 mmol) of triethylamine and 40 ml of ethyl ether. The reaction medium is heated at 35°C for 4 hours. The reaction changed very little, 20 ml of tetrahydrofuran, 0.3 ml of triethylamine and 0.2 ml (2.2 iranol) of dimethyl gulfate are added and the reaction medium is heated at 40°C for a further 24 hours. The reaction medium ia evaporated to dryness. The residue obtained is purified by thin-layer chromatography on silica eluted with a 97/3 and then 95/5 dichloromethane/methanol mixture. 0.1 g (16%) of methyl 2(S)-ethoxy-3-[4-(2-methyl-5~methylamino-2H-[l,2,4]trlazol-3-yl)phenyl]propanoate and 0.4 g (60%) of 2 (S)-ethoxy-3-[4-(2-methyl-5-methylamino-2H-[1,2,4]-triazol-3-yl)phenyl]proplonic acid are obtained. e- Methyl 2(S)-ethoxy-3-{4-[5-(3-heptyl-l-methyl-ureido)-2-methyl-2H-[1,2,4]triazol-3-yl]phenyl}-propanoate In a manner similar to that of Example 7(i), starting with 80 mg (0.25 mmol) of methyl 2(S}-ethoxy-3-[4-(2-methyl-5-methylamino-2H-[1,2,4]triazol-3-yl)phenyl]propanoate and 60 µ1 (0,4 mmol) of heptyl isocyanate, 37 mg (34%) of methyl 2(S)~ethoxy-3-{4-[5-(3-heptyl-l-methylureido)-2-inethyl-2H-[l,2,4]tria2ol-3-yl]phenyl}propanoate are obtained. f- 2(8}-Ethoxy-3-{4-[5-(3-heptyl-l-methylureido)-2-methyl-2H-[1,2,4]triazol-3-yl]phenyl}propanoic acid 37 mg (80 umol) of methyl 2(S)-ethoxy-3-{4-[5-(3-heptyl-l-methylureido)-2-roethyl-2H-[1,2, 4] triazol-3-yl]phenyl}propanoate placed in 2 ml of tetrahydrofuran and 0.1 ml (0.1 mmol) of aqueous 1M lithium hydroxide solution are stirred at room temperature overnight. The reaction medium is acidified to pH 4 and extracted with ethyl acetate. The organic phase is washed with water, with saturated sodium chloride solution, dried over magnesium sulfate, V filtered and evaporated. 30 mg (83%) of 2(S)-ethoxy-3-{4-[5-(3-heptyl-l-methylureido)-2-methyl-2H-[l,2,4]triazol-3-yl]phenyl}propanoic acid are obtained in the form of a white solid. 1H NMR (δ CDC13) : 0.88 (t, J = 6.7 Hz, 3H) ; 1.24 (t, J - 7.0 Hz, 3H); 1.26-1.39 (m, 8H); 1.60 (m, 2H); 3.13 (ddr J - 7.5 Hz, J = 4.1 Hz, 1H); 3.30 (ddf J - 4.1 Hz, J = 14 Hz, 1H); 3.38 (m, 2H); 3.47 (m, 3H); 3.54 (m, 1H); 3.68 {m, 1H); 3.93 (s, 3H); 4.10 (dd, J - 7.3 Hzr J - 4.2 Hz, 1H); 7.43 (d, J = 8.1 Hz, 2H); 7.61 (d, J = 8.1 Hz, 2H); 9.0 (s, 1H). Example 12: {3-[5-{2,4-dioxothiazolidin-5-Ylmethyl)-thiophen-2 -yl ] banzyl} mathyloctanoylamide a- tert-butyl [3-{5-Formylthiophen-2-yl)benzyl]methyl-carbamate In a manner similar to that of Example 7{f), starting with 3 g of Z-bromo-5-formylthlophene and 4 g of tert-butyl methyl[3-(4, 4, 5, 5-tetramethyl[1,3,2]-dioxaborolan-2-yl)benzyl]carbamate, 3 g of tert-butyl [3-(5-formylthiophen-2-yl)benzylImethylcarbamate are obtained. b- tert-butyl {3-[5-(2,4-Dioxothiazolidin-5-ylidene-methyl) thiophen-2-yl] benzyl }methylcarbamate A solution of 2.4 g (7.2 mrnol) of tert-butyl [3-(5-formylthiophen-2-yl)benzyl]methylcarbamate, 0.85 g (7.2 mmol) of 2,4-thiazolidinedione and 0.2 g (1.4 mmol) of piperidinium acetate in 50 ml of toluene is refluxed for 4 hours in Dean-Stark apparatus. After cooling, the product precipitates. The precipitate is filtered off and washed with ethyl ether. 2.3 g (76%) of tert-butyl {3-[5-(2,4-dioxothiazolidin-5-ylidene-methyl)thiophen-2-yl]benzylJmethylcarbamate are obtained. c- tert-butyl {3-[5-(2,4-Dioxothiazolidin-5-ylmethyl)-thiophen-2-yl]benzylJmethylcarbamate 1 g (2.5 mmol) of tert-butyl {3-[5-(2,4-dioxothiazolidin-5-ylidenemethyl)thiophen-2- yl]benzyl}methylcarbamate is placed in 20 ml of dioxane and 0.2 ml of acetic acid. The reaction medium is degassed and placed under 3 atm of hydrogen for 3 days. After filtration through Cellte, 0.2 g (20%) of tert-butyl {3-[5-(2, 4-dioxothiazolidin-5-ylmethyl)thiophen-2-yl]benzyl}methylcarbamate is obtained. d- 5-[5- (3-Methylaminoraethylphenyl)thiophen-2-yl-methyl]thiazolidlne-2,4-dione 0.2 g (0.5 mmol) of tert-butyl 3-[5-(2,4-dioxothiazolidin-5-ylmethyl)thiophen-2~yl]benzyl}-methylcarbamate is placed in 10 ml of dichloromethane and 0.2 ml of trifluoroacetic acid for 12 hours. The reaction medium is evaporated to dryness and 200 mg (100%) of 5-[5-(3-methylaminomethylphenyl)thiophen-2-ylmethyl]thiazolidine-2,4~dione ar-e obtained. e- {3-[5-(2,4-dioxothlazolidin-5-ylmethyl)thiophen-2-yl]benzyl}methyloctanoylamide In a manner similar to that of Example l(b), starting with 90 mg (0.3 mmol) of 5-[5-(3-methylamino-methylphenyl)thiophen-2-ylmethyl]thiazolidine-2,4-dione and 32 pi (0.3 mmol} of octanoyl chloride, 61 mg (92%) of {3-[5-(2,4-dioxothiazolidin-5-ylmethyl)thiophen-2-yl]benzyl}methyloctanoylamide are obtained. 1H NMR (δ CDC13) : 0.92 (t, J - 6.7 Hz, 3H); 1.30-1.37 (m, 8H); 1.54 (m, 2H); 2.9 (s, 3H); 3.23 (m, 1H); 3.50 (m, 1H); 3.74 (m, 1H); 4.75 (m, 1H); 4.79 (m, 2H); 6.93-7.50 (m, 6H) . Example 13: {3-[5-{2,4-dioxothiazolidin-5-ylmethyl)-thiophen-2-yl]benzyl }}Methylhexanoylamida In a manner similar to that of Example 12(e)r starting with 90 nig (0.3 mmol) of 5- [5- (3-methylamino-raethylphenyl)thiophen-2-ylmethyl]thiazolidine-2,4-dione and 26 µl (0-3 mmol) of hexanoyl chloride, 22 mg (20%) of {3-[5-(2,4-dioxothiazolidin-5-ylmethyl)thiophen~2-yl]benzyl}methylhexanoylamlde are obtained. 1H NMR (δ CDC13) : 0.92 (t, J = 6.7 Hz, 3H) ; 1.30-1.37 (mr 4H) 1.54 (m, 2H); 2.9 (s, 3H); 3.23 (m, 2H); 3.50 (m, 1H); 3.74 (m, 1H); 4.75 {m, 1H); 4.79 (m, 2H) ; 6.93-7.50 {m, €H}. Exampl* 14: 2 (S) - (2-Benzoylphenylamino) -3- {4-{5-t (ootanoylmathylamino)methyl] thiophen-3-yl}phenyl) -propanoie acid a- Methyl 2(3)-(2-benzoylphenylamino) -3-(4-hydroxy-phenyl)propanoate A solution of 56 g (0.29 mmol) of L-tyrosine methyl ester, 64 g (0.32 mmol) of benzoylcyclohexanone and 12 g of 10% palladium-on-charcoal in 700 ml of anisole is heated at 158°C for 17 hours. The reaction medium is cooled to 50°C, filtered through Celite and evaporated under vacuum. The crude product obtained is taken up in a dichloromethane/pentane mixture and precipitated. After filtration, 18 g (20%) of methyl 2(S)-(2-benzoylphenylamino)-3-(4-hydroxyphenyl)-propanoate are obtained. b- Methyl 2(S)-(2-benzoylphenylamino)-3-(4-trifluoro-methanesulfonyloxyphenyl)propanoate 1.2 g (10 mmol) of 4-dimethylaminopyridine are added to a mixture of 24.5 g (65 mmol) of methyl 2(S) -(2-benzoylphenylamino)-3-(4-hydroxyphenyl)-propionate and 11 ml (78 mmol) of triethylamine in 220 ml of dichloromethane, The reaction medium is cooled to -78°C and 13.2 ml (78 mmol) of triflic anhydride are added dropwise. The reaction medium is stirred from -78°C to room temperature over 4 hours. After addition of saturated ammonium chloride solution, the reaction medium is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated. 33 g (100%) of methyl 2(3)-(2-benzoylphenylamino)-3- (4-trifluoromethanesulfonyl-oxyphenyl)propanoate are obtained. c- Methyl 2(S)- (2-benzoylphenylamino)-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]propanoate In a manner similar to that of Example 7(e), starting with 28 g (55 mmol) of methyl 2(S)-(2-benzoylphenylamino) -3-(4-trifluoromethanesulfonyloxyphenyl)-propanoate, 24.2 g (90%) of methyl 2(S)-(2-benzoylphenylamino) -3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxa-borolan-2-yl)phenyl]propanoate are obtained. d- Methyl 2 (S)-(2-benzoylphenylaraino)-3-(4-{5-[tert-butoxycarbonylmethylamino)methyl] thiophen-3-yl}phenyl) -propanoate In a manner similar to that of Example 7(f), starting with 6 g (17 mmol) of methyl 2-(2-benzoyl-phenylamino)-3-[4- (4,4,5,5-tetramethyl11,3,2]dioxa-borolan-2-yl)phenyl]propanoate and 3.6 g (12 nunol) of tert-butyl (4-bromothiophen-2-ylmethyl)methylcarbamate (prepared as described in 16b), 2.9 g (42%) of methyl 2(S)-(2-benzoylphenylamino)-3-(4-(5-[(tert-butoxy-carbonylmethylatid.no) methyl] thiophen-3-yl}phenyl} -propanoate are obtained. e- Methyl 2(S)-(2-benzoylphenylamino)-3-[4-{5-methyl-aminomethylthiophen-3-yl) phenyl] propanoate 2.9 g (5 mmol) of methyl 2(S)-(2-benzoyl-phenylamlno)-3- (4-{5-[{tert-butoxycarbonylmethyl-amino)methyl]thiophen-3-yl}phenyl)propanoate are placed in 30 ml o'f dichloromethane and 2.5 ml (32 mmol) of trifluoroacetic acid. After stirring at room temperature for 18 hours, the reaction medium is evaporated to dryness. 2.4 g (100%) of methyl 2(S)-(2-benzoylphenylamino) -3- [4- (5-methylaminomethylthiophen-3-yl)phenyl]propanoate are obtained. f- Methyl 2 (S)-{2-benzoylphenylamino)-3-(4-{5-[(methyl-octanoylamino)methyl]thiophen-3-yl}phenyl)propanoate In a manner similar to that of Example 1(b), starting with 0.8 g (1.65 mmol) of methyl 2(S)-(2-benzoylphenylamino)-3-[4-(5-methylaminomethylthiophen-3-yl)phenyl]propanoate and 0.3 ml (1.8 mmol) of octanoyl chloride, 0.8 g (78%) of methyl 2(S)-(2-benzoylphenylamino)-3-(4-{5-[(methyloctanoylamino)-methyl]thiophen-3-yl}phenyl)propanoate are obtained. g- 2(S)-(2-Benzoylphenylamino)-3-(4-{5-[ (methyl- • octanoylamino)methyl]thiophen-3-yl}phenyl)propanoi c acid In a manner similar to that of Example 7(j), starting with 0.8 g (1 mmol) of methyl 2(3)-(2-benzoylphenyland.no)-3-(4-{5-[(methyloctanoylamino)-methyl]thiophen-3-yl}phenyl)propanoate, 0.5 g (63%) of 2(S)-(2-benzoylphenylamino)-3-(4-{5-[ (methyloctanoyl-amino)methyl]thiophen-3-yl}phenyl)propanoic acid is obtained. 1H NMR (δ CDC13) : 0.89 (t, J = 6.7 Hz, 3H); 1.29-1.32 (m, 16H); 1.68 (m, 2H); 2.35-2.48 (m, 2H); 2.99 {a, 3H); 3.23 (m, 1H); 3.37 (m, 1H); 4,48 (m, 1H); 4.66 (s, 2H) ; 6.60 (t, J - 7.3 Hz, 1H); 6.72 a- Methyl 2(S)-(2-benzoylphenylamino)-3-(4-{5- [(hexanoylmethylamino)methyl]thiophen-3-yl}phenyl)- propanoate In a manner similar to that of Example l(b), starting with 0.8 g {1.65 mmol) of methyl 2(S)-(2-benzoylphenylamino)-3-[4-(5-methylaminomethylthiophen-3-yl)phenyl]propanoate and 0.25 ml (1.8 mmol) of hexanoyl chloride, 0.8 g (78%) of methyl 2 {S)~(2-benzoylphenylamino) -3-(4-{5-[(methylhexanoylamino)-methyl]thiophen-3-yl}phenyl)propanoate is obtained. b- 2(3)-(2-Benzoylphenylamino)-3-(4-{5-[(hexanoyl-methylamlno)methyl]thiophen-3-yl}phenyl)propanoic acid In a manner similar to that of Example 7(j)r starting with 0.6 g (1 mmol) of methyl 2(S)-(2-benzoylphenylamino) -3-(4-{5-[(methylhexanoylamino) methyl]-thiophen-3-yl}phenyl)propanoate, 0.57 g (100%) of 2(S}-(2-benzoylphenylamino)-3-(4-{5-[ (methylhexanoylamino)-methyl]thiophen-3-yl}phenyl)propanoic acid is obtained. 1H NMR (δ CDC13) : 0.92 (t, J = 6.7 Hz, 3H) ; 1.30-1.36 (m, 4H); 1.70 (m, 2H°; 2.33-2.47 (m, 2H); 3.00 (e, 3H); 3.23 (dd, J = 5.4 Hz, J - 13.9 Hz, 1H); 3.38 (dd, J « 5.4 Hz, J - 8.5 Hz, 1H); 4.45 (m, 1H); 4.66-4.70 (m, 2H); 6.67 (t, J - 7.5 Hz, 1H); 6.71 (d, J = 8.4 Hz, 1H); 7.19-7.62 (m, 13H); 9.0 (s, 1H). Example 16: 2 (S)-Ethoxy-3-(4-{5-[ (hexanoylmethylamino)-methyl] thiophen-3-yl}ph«nyl)propanoic acid a- (4-Bromothiophen-2-ylmethyl)niethylamine 25.2 g (360 romol) of aodiuin cyanoborohydride are added to a solution of 35 g (180 mmol) of 4-bromo-thiophene-2~carbaldehyde, 62 g (640 mmol) of methyl-amine hydrochloride and 119 ml (846 mmol') of triethyl-amine. The reaction medium is stirred at room temperature for 3.5 hours. After addition of water and ethyl acetate and washing with aqueous 1M sodium hydroxide solution, the organic phase is extracted. The ethyl acetate phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 90/10 to 70/30 heptane/ethyl acetate mixture. 19.7 g (52%) of (4-bromothiophen-2-ylmethyl)methylamine are obtained. b- tert-butyl {4-Bromothiophen-2-ylmethyl)methyl-carbamate 20.8 g (95 mmol) of di-tert-butyl dicarbonate are added portionwise to a solution of 19.7 g (95 mmol) of (4-bromothiophen-2-ylmethyl)methylamine and 11.9 ml (85 mmol) of triethylamine in 200 ml of dichloro-methane. After stirring at room temperature for 16 hours, the reaction medium is washed with water and the dichloromethane phase is extracted. The organic phase IS dried over magnesium sulfate, filtered and evaporated. 19 g (44%) of tert-butyl (4-bromothiophen-2-ylmetnyl)methylcarbamate are obtained. c- Methyl 3-(4-{5-[ {tert-butoxycarbonylmethylamino)-methyl]thiophen-3-yl}phenyl)-2(S) -ethoxypropanoate In a manner similar to that of Example 9(e)r starting with 4 g (13 mmol) of tert-butyl (4-bromo-thiophen-2-ylmethyl)methylcarbamate and 5.6 g (20 mmol} of methyl 2(S)-ethoxy-3-[4-{4, 4, 5, 5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]propanoate, 5 g (88%) of methyl 3-{4-{5- [ (tert-butoxycarbonylmethylamino)-methyl]thiophen-3-yl}phenyl)-2(S}-ethoxypropanoate are obtained in the form of a yellow oil. d- Methyl 2(S)-ethoxy-3-[4-(5-methylaminomethyl-thiophen-3-yl)phenyl]propanoate 5 g (11.5 mmol) of methyl 3-(4-{5-[(tert-butoxycarbonylmsthylamino)methyl]thiophen-3-yl}phenyl)-2(S)-ethoxypropanoate are placed in 80 ml of dichloro-methane and 4.4 ml of trifluoroacetic acid. After stirring at room temperature for 24 hours, water is added and the reaction medium is extracted with dichloromethane. The dichloromethane phase is washed with aqueous 30% sodium hydroxide solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica elutad with a 50/50 heptane/ethyl acetate mixture. 3.2 g (84%) of methyl 2(S)-ethoxy-3- [4-{5-raethylaminomethylthiophen-3-yl)phenyl]propanoate are obtained. e- Methyl 2{S}-ethoxy-3-(4-{5-[{hexanoylmethylamino}-methyl]thlophen-3-yl}phenyl)propanoate 0.1B ml (1.3 mmol) of hexanoyl chloride is added to a solution, cooled beforehand to 0°C, of 0.4 g (1.2 racnol) of methyl 2(S)-ethoxy-3-[4-(5-methylamino-methylthiophen-3-yl)phenyl]propanoate and 0.18 ml (1.3 mmol) of triethylamine in 20 ml of tetrahydrofuran. The reaction medium is stirred at room temperature for 2 hours, washed with water and extracted with ethyl acetate. The ethyl acetate phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 70/30 heptane/ethyl acetate mixture. 0.4 g (83%) of methyl 2(S)-ethoxy-3-(4-{5-[(hexanoylmethylamino)-methyl]thiophen-3-yl}phenyl)propanoate is obtained. f- 2(S)-Ethoxy-3-(4-{5-[{hexanoylmethylamino)methyl]-thiophen-3-yl)phenyl)propanoic acid In a manner similar to that of Example 11 (f), starting with 0.4 g {1 mmol) of 2(S)-ethoxy-3-(4-{5-[(hexanoylmethylamino)methyl]thiophen-3-yl}phenyl)-propanoate, 0.4 g of crude residue is obtained. This residue is hot-recrystallized from isopropyl ether. 0.2 g (50%) Of 2(S}-ethoxy-3-(4-{5- [ (hexanoylmethylartd.no)methyl] thiophen-3- yl}phenyl)propanoic acid is obtained in the form of a white solid with a melting point of 65°C. 1H NMR (δ CDC13) : 0.90 (t,.J = 6.7 Hz, 3H) ; 1.19 (t, J = 7.0 Hz, 3H); 1.35-1.37 (m, 4H); 1.70 (m, 2H); 2.36-2.48 (m, 2H); 3.02 (m, 1H); 3.03 (s, 3H); 3.15 (m, 1H); 3.45 (m, 1H); 3.65 (m, 1H); 4.10 (m, 1H); 4.69-4.74 (m, 2H); 7.19-7.35 (m, 4H); 7.50 (d, J = 8.2 Hz, 2H). Example 17: 3- (4- a- Methyl 3-(4-{5-[(butyrylmethylamino)methyl]thiophen-3-yl}phenyl-2(S)-ethoxypropanoate In a manner similar to that of Example 16(e), starting with 0.1 g (0.3 mmol) of methyl 2(S)-ethoxy-3-[4-(5-methylaminomethylthiophen-3-yl)phenyl]propanoate and 40 µl (0.33 mmol) of butanoyl chloride, 0.12 g (75%) of methyl 3-(4-{5-[(butyrylmethylamino)methyl]-thiophen-3-yl}phenyl)-2(S)-ethoxypropanoate is obtained. b- 3- (4-{5-[{Butyrylmethylamino)methyl]thiophen-3-yl}-phenyl)-2(S)-ethoxypropanoic acid In a manner similar to that of Example 11(f), starting with 90 mg (0.22 nrnvol) of methyl 3-(4-{5-[(butryrylmethyland.no)methyl]thiophen-3-yl}phenyl-2(S)-ethoxypropanoate, 45 mg (52%) of 3-(4-{5- [(butyrylmethylamino)methyl]thiophen-3-yl}phenyl)-2(S)-ethoxypropanoic acid are obtained in the form of a solid with a melting point of 56-57°C. 1H NMR (δ CDC13) : 1.00 (t, J - 6.7 Hz, 3H) ; 1.19 (t, J- 7.0 Hz, 3H); 1.74 (m, 2H) ; 2.36-2.48 (m, 2H); 3.02 (m, 1H); 3.03 (s, 3H); 3.15 (m, 1H); 3.48 (m, 1H); 3.65 (m, 1H); 4.11 {m, 1H); 4.69-4.74 (m, 2H}; 7.19-7.35 (m, 4H); 7.50 (df J - 8.2 Hz, 2H). Example 18: 3-[4-(5M [(3-Cyalohexylpropionyl)methyl-amino]methyl} thiophen-3-yl)phenyl] -2 (8) -ethoxypropanoic acid a- Methyl 3-[4-(5-{[(2-cyclopentylacetyl)methylamino]-methyl}thiophen-3-yl)phenyl]-2(S)-ethoxypropanoate In a manner similar to that of Example 16(e), starting with 0.35 g (1 mmol) of methyl 2(S)-ethoxy-3-[4-(5-methylaminomethylthiophen-3~yl)phenyllpropanoate and 170 µl (1.15 mmol) of 2-cyclopentylacetyl chloride, 0.39 g (85%) of methyl 3-[4-(5-{[(2-cyclopentylacetyl)-methylamino] methyl}thiophen-3-yl)phenyl]-2(S)-ethoxypropanoate is obtained. b- 3-[4-(5-{ [ (2-CyclopentylacetyDmethylamino] methyl }-thiophen-3-yl)phenyl]-2(S)-ethoxypropanoic acid In a manner similar to that of Example 11(f), starting with 0.39 g (0.88 mmol) of methyl 3-[4-(5-{[(2~cyclopentylacetyl)methylamino]methyl}thiophen-3-yl)phenyl]-2(S)-ethoxypropanoate, 0.24 g (63%) of 3-[4- (5-{[(2-cyclopentylacetyl)methylamino]methyl}thiophen-3-yl)phenyl]-2(S)-ethoxypropanoic acid is obtained in the form of a solid with a melting point of 112-113°C. 1H NMR (δ CDC13) : 1.19 (t, J = 7.0 Hz, 3H); 1.60-1.65 (m, 4H); 1.90 {m, 2H); 2.30 Cm, 1H); 2.37-2.52 (m, 2H); 3.02 (m, 1H); 3.04 (s, 3H); 3.17 (m, 1H); 3.48 {m, 1H); 3.65 (m, 1H); 4.12 (m, 1H); 4.70-4.75 (m, 2H); 7.19-7.36 (m, 4H); 7.50 (d, J= 8.2 Hz, 2H). Example 19: 3-[4-{5-{ [ (3-Cycloh«xylpropionyl)methyl-amino]methyl} thiophen-3-yl)phenyl] -2 (S) -•thoxypropanola acid a- Methyl 3- [4~{5-{ [ (3-cyclohexylpropionyl) methyl-amino]methyl}thiophen-3-yl)phenyl]-2(S)-ethoxy-propanoate In a manner similar to that of Example 16(e), starting with 0.35 g (1 mmol) of methyl 2 (S)-ethoxy-3-[4- (5-methylaminomethylthiophen-3-yl)phenyllpropanoate and 170 µl (1.15 mmol) of 2-cyclopentylacetyl chloride, 0.41 g (84%) of methyl 3-[4-{5-{[(3-cyclohexylpropionyl )methylamino]methyl}thlophen-3-yl) phenyl] -2(S)-ethoxypropanoate is obtained. b- 3-[4-(5-{ [ (3-CyclohexylpropionyDmethyland.no] -methyl}thiophen-3-yl)phenyl]-2(S)-ethoxypropanoic acid In a manner similar to that of Example 11 (f), starting with 0.41 g (0.87 mmol) of methyl 3-[4-(5-{[(3-cyclohexylpropionyl}methylamino]methyl}thiophen-3- yl)phenyl]~2(S)-ethoxypropanoate, 0.23 g (57%) of 3-[4-(5-{ [ (3-cyclohexylpropionyDmethylamino] methyl }-thlophen-3~yl)phenyl]-2(S)-ethoxypropanoic acid is obtained in the form of a solid with a melting point of 69-70°C. 1H NMR {δ CDC13) : 0.95 (m, 2H) , 1.19 (t, J = 7.0 Hz, 3H); 1.20-1.28 (m, 4H); 1.57 (m, 1H); 1.58-1.72 {m, 6H); 2.37-2.49 (m, 2H); 3.02 (m, 1H) ; 3.04 (s, 3H); 3.15 (m, 1H); 3.47 (m, 1H); 3.63 (m, 1H) ; 4.12 (m, 1H); 4.69-4.74 {m, 2H); 7.19-7.36 {m, 4H); 7.50 (d, J - 8.2 Hz, 2H). Example 20: 2-Ethoxy-3-{6-[3-(3-heptyl-l-methylureido}-ph«nyl]pyrid-3-yl}propanoia aaid a- (6-Iodopyrid-3-yl)methanol 30 g (108 mmol} of ethyl 6-iodonicotinate dissolved in 300 ml of ethanol are added dropwise to a solution of 20.5 g {542 mmol) of sodium borohydride in 200 ml of ethanol, cooled beforehand to 0°C. The reaction medium is allowed to warm to room temperature and is then stirred for 1 hour 30 minutes at room temperature. The reaction medium is hydrolysed and extracted with ethyl acetate. The boron salts precipitate out, and the medium is filtered and then evaporated to dryness. The reaction medium is taken up in dichloromethane, the product precipitates out, isopropyl ether is added and the medium is filtered. The precipitate is washed with isopropyl ether. 17 g (67%) of (6-iodopyrid-3-yl)methanol are obtained in the form of a pale yellow solid with a melting point of 102°C. b- 6~Iodopyridine-3-carbaldehyde 63 g (723 initial) of manganese dioxide are added to a solution of 17 g (72 mmol) of (6-iodopyrid-3-yl)methanol in 600 ml of dichloromethane. The reaction medium is stirred at room temperature for 20 hours and then filtered through Celite. The precipitate is washed thoroughly with water and the filtrate is evaporated under vacuum. The residue obtained is taken up in dichloromethane and the insoluble material is again filtered off. After evaporation of the filtrate, 13.2 g (78%) of 6-iodopyridine-3-carbaldehyde are obtained in the form of a pale yellow solid with a melting point of 141°C. c- tert-butyl [3-(5-Formylpyrid-2-yl)phenyl]methyl- carbamate c.l: tert-butyl {3-Bromophenyl)methylcarbamate 8.4 g (209.4 mmol) of 60% sodium hydride are added portionwise to a solution of 19 ml (174 mmol) of 3-bromoaniline in 300 ml of tetrahydrofuran. The reaction medium is stirred at room temperature until the evolution of gas has ceased, and 38 g (174 mmol) of di-tert-butyl dicarbonate disaolved in 40 ml of tetrahydrof uran are then added dropwise. The reaction medium is stirred at reflux for 8 hours and then at room temperature for 18 hours. Water is added and the reaction medium is extracted with ethyl acetate. The ethyl acetate phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 90/10, then 80/20 and 70/30 heptane/ethyl acetate mixture. 47 g (92%) of tert-butyl (3-bromophenyl) methylcarbamate are obtained. c.2: tert-butyl (3-Bromophenyl)methylcarbamate 7.6 g (190 mmol) of 60% sodium hydride are added portionwise to a solution of 47 g (173 mmol) of 15 tert-butyl (3-bromophenyl)methylcarbamate in 500 ml of dimethyl formamide. After the evolution of gas has ceased, 54 ml (865 mmol) of methyl iodide are added and the reaction medium is stirred at room temperature for 5 hours. After addition of water, the medium is extracted with ethyl acetate. The ethyl acetate phase is washed thoroughly with water, dried over magnesium sulfate, filtered and evaporated. 49 g (100%) of tert-butyl (3-bromophenyl)methylcarbamate are obtained. c.3: tert-butyl Methyl-[3-(4,4,5,5-tetramethyl[1,3,2]-dioxaborolan-2-yl)phenyl]carbamate In a manner similar to that of Example 7(e), starting with 5 g (17.5 mmol) of tert-butyl (3-bromo- phenyl)methylcarbamate, 3.4 g (60%) of tert-butyl methyl[3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]carbamate are obtained. c.4: tert-butyl [3-(5-Formylpyrid-2-yl)phenyl]methyl-carbamate In a manner similar to that of Example 7(f), starting with 1.6 g (6.8 mmol) of 6-iodopyridine-3-carbaldehyde and 3.4 g {16.2 mmol) of tert-butyl methyl [3- (4,4,5,5-tet'ramethyl [1,3,2] dioxaborolan-2-yl)phenyllcarbamate, 1.2 g (58%) of tert-butyl [3-(5-formylpyrid-2-yl)phenyl]methylcarbamate are obtained. d- Ethyl 3-{6-13- (tert-butoxycarbonylmethylamino)-phenyl]pyrid-3-yl}-2-ethoxyacrylate d.l: Ethyl chloroethoxyacetate A solution of 40 ml (224 mmol) of ethyl diethoxyacetate, 19 ml (268 mmol) of acetyl chloride and 0.1 g (0.45 mmol) of iodine is heated at 50°C for 4 hours. Only 60% of the desired product is formed. The reaction medium is cooled to room temperature, 19 ml (268 mmol) of acetyl chloride are added and the medium la heated at 50°C for a further 18 hours. The reaction medium is evaporated to dryness under vacuum. 36.3 g (100%) of crude ethyl chloroethoxyacetate are obtained. d.2: Ethyl (diethoxyphosphoryl)ethoxyacetate 36.3 g (218 mmol) of ethyl chloroethoxy- acetate and 37.4 ml (218 mmol} of triethyl phosphite are heated at 50°C for 3 hours. The reaction medium is evaporated to dryness under vacuum. 57 g (100%) of crude ethyl (diethoxyphosphoryl)ethoxyacetate are obtained. d.3: Ethyl 3-{6-[3-(tert-butoxycarbonylmethylamino)-phenyl]pyrid-3-yl}-2-ethoxyacrylate 0.3 g (8 mmol) of 60% sodium hydride is added portionwise to a solution of 2.1 g (8 mmol) of ethyl (diethoxyphosphoryl}ethoxyacetate in 8 ml of tetra-hydrofuran. After stirring at room temperature for 30 minutes and after the evolution of gas has ceased, 1.2 g (4 mmol) of tert-butyl [3-(5-formylpyrid-2-yl)phenyl]methylcarbamate dissolved in 6 ml of tetrahydrofuran are added. The reaction medium is stirred at room temperature for 18 hours. The reaction medium is diluted with water and extracted with ethyl acetate. The organic phase is washed with water, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 90/10, then 80/20 and 70/30 heptane/ethyl acetate mixture. 0.2 g (12%) of ethyl 3-{6-[3-(tert-butoxycarbonylmethyl-amino)phenyl]pyrid-3~yl}-2-ethoxyacrylate is obtained. f- Ethyl 3-{6-[3-(tert-butoxycarbonylmethylamino)-phenyl]pyrid-3-yl}-2-ethoxypropanoate A solution of 0,2 g (0.5 mmol) of ethyl 3-{6-[3-{tert-butoxycarbonylmethylamino)phenyl]pyrid-3-yl}-2-ethoxyacrylate in 10 ml of tetrahydrofuran is degassed and 0.02 g (10% by mass) of 10% Pd/C is added. After reaction for 5 hours under an atmospheric pressure of hydrogen, the reaction medium is stirred under 3 atm of hydrogen for 24 hours. After filtration through Celite and evaporation of the filtrate, 0.11 g (55%) of ethyl 3-{6-[3-{tert-butoxycarbonylmethyl-amino}phenyl]pyrid-3-yl}-2-ethoxypropanoate is obtained. g- Ethyl 2-ethoxy-3-[6-{3-methylaminophenyl)pyrid-3-yl]propanoate 0.11 g (0.3 mmol) of ethyl 3-{6-[3-(tert-butoxycarbonylmethylamino)phenyl]pyrid-3-yl}-2-ethoxypropanoate, • 5 ml of dichloromethane' and 0.15 ml (1.9 mmol) of trifluoroacetic acid are stirred at room temperature for 24 hours. After addition of water, the reaction medium is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated. 80 mg (94%) of ethyl 2-ethoxy-3-[6-(3-methylaminophenyl)pyrid-3-yl]propanoate are obtained. h- Ethyl 2-ethoxy-3-{6-[3-(3-heptyl-l-methylureido)-phenyl]pyrid-3-yl}propanoate 80µl (0.5 mmol) of heptyl isocyanate are added to 80 mg (0.24 mmol) of ethyl 2-ethoxy-3-[6-(3- methylaminophenyl)pyrld-3-yl]propanoate in 5 ml of dichloromethane. After stirring at room temperature for 24 hours, water is added and the reaction medium is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 60/40 heptane/ethyl acetate mixture. 60 mg (54%) of ethyl 2-ethoxy-3-{6-[3-{3-heptyl-l-methylureido)phenyl]pyrid-3-yl}propanoate are obtained. i- 2-Ethoxy-3-{ 6- [3- (3-heptyl-l-methylureido) phenyl] -pyrid-3-yl}propanoic acid 60 mg (0.13 mmol) of ethyl 2-ethoxy-3-{6-[3-(3-heptyl-l-methylureido)phenyl]pyrid-3-yl}propanoate are placed in 4 ml of tetrahydrofuran, 0.2 ml (0.2 mmol) of aqueous 1M lithium hydroxide solution is added and the mixture is stirred at room temperature for 24 hours. After acidic hydrolysis to pH 4.5-5, the reaction medium is extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 50/50 heptane/ethyl acetate mixture and then a 90/10 dichloromethane/methanol mixture. 40 mg (70%) of 2-ethoxy-3-{6- [3-(3-heptyl-l-methylureido)phenyl]pyrid-3-yl}propanoic acid are obtained in the form of a white solid with a melting point of 142-143°C. 1H NMR (δ CDC13) : 0.86 (t, J = 6.7 Hz, 3H), 1.19 {t, J - "7.0 Hz, 3H) ; 1.20-1.25 (m, 8H); 1.42 (m, 2H) ; 3.15 {m, 1H); 3.18 (m, 2H); 3.19 (m, 1H) ; 3.34 (s, 3H); 3.53 (m, 1H); 3.72 {m, 1H); 4.41 (m, 1H); 7.30 (m, 1H); 7.50-7.85 (m, 5H); 8.60 (m, 1H). Example 21: 2(S)- (2-B«nzoylphenylamino)-3-{4-[6- (1-m»thyl-3-pentylureido) pyrid-2-yl]pb«nyl}propanoia aeld a- Methyl 2{S)- (2-benzoylphenylamino}-3-(4-[6-(tert-butoxycarbonylmethylamino) pyrid-2-yl]phenyl}propanoate In a manner similar to that of Example 14 Id), starting with 12.7 g (26 mmol) of methyl 2-(2-benzoyl-phenylamino)-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxa-borolan-2-yl)phenyl]propanoate and 5 g (17 mmol) of tert-butyl (3-bromophenyl)methylcarbamate (prepared as described in 9b), 8.3 g (84%) of methyl 2(3)-(2-benzoylphenylamino)-3-{4-[6-(tert-butoxycarbonylmethyl-amino)pyrid-2-yl]phenyl}propanoate are obtained. b- Methyl 2(S)-(2-benzoylphenylamino)-3-[4-(6-methyl-aminopyrid-2-yl)phenyl]propanoate In a manner similar to that of Example 14(e), starting with 8.3 g (15 mmol) of methyl 2(S)-(2-benzoylphenylamino)-3-{4-[6-(tert-butoxycarbonylmethyl-amino)pyrid-2-yl]phenyl}propanoate, 7.1 g (100%) of methyl 2(S)-(2-benzoylphenylaraino)-3-[4-(6-methyl-aminopyrid-2-yl)phenyllpropanoate are obtained. c- Methyl 2 (S)-(2-benzoylp'henylamino)-3-{4-[6-(1-methyl~3-pentylureido)pyrid-2-yl]phenylJpropanoate In a manner similar to that of Example 7(i), starting with 0.9 g (1.9 mmol) of methyl 2(S)-(2-benzoylphenylamino)-3-[4-(6-methylamlnopyrid-2-yl)phenyl]propanoate and 0.35 ml (2.1 mmol) of pentyl isocyanate, 0.7 g (63%) of methyl 2(3)-(2-benzoylphenylamino)-3-{4-[6-(l-methyl-3-pentylureido)pyrid-2-yl]phenyl}propanoate is obtained. d- 2(3)-(2-Benzoylphenylamino)-3-{4-[6-(l-methyl-3-pentylureido)pyrid-2-yl]phenyl}propanoic acid In a manner similar to that of Example 7(j), starting, with 0.22 g (0.4 ramol) of methyl 2(S)-(2-benzoylphenylamino)-3-{4-[6-(l-methyl-3-pentylureido)-pyrid-2-yl]phenylIpropanoate, 0.2 g (95%) of 2(S)-(2-benzoylphenylamino)-3-{4-['6-(l-methyl-3-pentylureido)-pyrid-2-yllphenyl}propanoic acid is obtained. 1H NMR (δ CDC13) : 0.77 (t, J - 6.7 Hz, 3H) ; 1.23-1.25 (m, 4H); 1.53 (m, 2H); 3.20-3.46 (m, 4H) ; 3.41 (a, 3H) ; 4.47 {m, 1H); 6.59 (t, J- 7.4 Hz, 1H); 6.68 (d, J = 8.5 Hz, 1H); 6.86 (d, J = 8.5 Hz, 1H); 7.22-7.73 (m, 13H); 9.0 (a, 1H); 10.5 (3, 1H). Example 22: 2(8)-(2-Benzoylphanylamino)-3-{4-[6-(1-methy 1 - 3 -hep tylureido) pyr id-2 -yl ] phenyl} prppanoio aoid a- Methyl 2(S)-(2-benzoylphenylamino)-3-{4-16-(1-methyl-3-heptylureido)pyrid-2-yl]phenyl}propanoate In a manner similar to that of Example 7(i), starting with 0.35 g (0.7 mmol) of methyl 2(S)-{2-benzoylphenylamino)-3-[4-(6-methylaminopyrid-2-yl)-phenyl]propanoate and 0.3 ml (2.1 nrniol) of heptyl iaocyanate, 0.4 g (94%) of methyl 2(S)-(2-benzoyl-phenylamino)-3-(4-[6-(l-methyl-3-heptylureido)pyrid~2-yl]phenyl)propanoate is obtained. b- 2(S)- (2-Benzoylphenylamino)-3-{4-[6-(l-methyl-3-heptylureido)pyrid-2-yl]phenyl}propanoic acid In a manner similar to that of Example 7{j), starting with 0.7 g (0.4 mmol) of methyl 2(S)-(2-benzoylphenylamino)~3-{4-[6-(l-methyl-3-heptylureido)-pyrid-2-yl]phenyl}propanoate, 0.65 g (90%) of 2(S)-(2-benzoylphenylamino)-3-{4-[6-(l-methyl-3-heptylureido)-pyrid-2-yl]phenyl}propanoic acid is obtained. 1H NMR (δ CDC13) : 0.83 (t, 3H, J = 6.7 Hz); 1.15-1.28 (m, 4H) ; 1.51-1.58 (m, 2H); 3.27 .(dd, 1H, J = 13.8 Hz, J = 7.9 Hz); 3.31 (m, 2H); 3.42 (s, 3H); 3.44 (dd, 1H, J = 1.4 Hz, J - 13.8 Hz); 4.50 (m, 1H); 6.62 (t, J = 7.4 Hz, 1H); 6.73 (d, J - 8.5 Hz, 1H); 6.89 (d, J = 8.5 Hz, 1H); 7.29-7.77 (m, 13H); 9.0 (m, 1H); 10.5 (m, 1H). Example 23: 2(S)-Ethoxy-3-{6-[3-(3-heptyl-l-«ethyl-uraido)phenyl]pyrid-3-yl}propanoic acid a- 2(S)-Ethoxy-3-[6-(3-methylaminophenyl)pyrid-3-yl]propanoic acid 0.9 g {2.7'mmol) of ethyl 2-ethoxy-3-[6-(3-methylaminophenyl}pyrid-3-yl]propanoate, prepared as described in Example 2Dg, is placed in 60 ml of a pH 7 buffer solution, with 0.75 g of the enzyme Proteinase 2A. After 10 days at room temperature, the reaction has not progressed. The reaction medium is heated at 37°C for 1 day: the reaction is complete. Water is added, the pH is brought to 8 by addition of 1M sodium hydroxide solution and the reaction medium is extracted with ethyl acetate. The ethyl acetate phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The aqueous phase is acidified with aqueous IN acetic acid solution to pH 4 and extracted with ethyl acetate. The ethyl acetate phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 95/5, 90/10 and then 80/20 dichloromethane/methanol mixture. 0.1 g (24%) of 2(S)-ethoxy-3-[6-{3-methylaminophenyl)pyrid-3-yl]propanoic acid is obtained. b- Methyl 2 (S)-ethoxy-3-[6-( 3-methylaminophenyl)pyrid-3-yl] propanoate 0.1 g {0.3 mmol) of 2(S)-ethoxy-3-[6-(3-methylaminophenyl)pyrid-3-yl] propanoic acid is placed in 5 ml of methanol and 2 drops of concentrated sulfuric acid are added. The reaction medium is heated at 65°C for 18 hours. The methanol is evaporated off and the residue is taken up in an ethyl acetate/water mixture. The pH is brought to 7 by addition of 1N sodium hydroxide solution and the reaction medium is extracted with, ethyl acetate. The ethyl acetate phase is dried over sodium aulfate, filtered and evaporated. 70 mg (70%) of methyl 2(S)-ethoxy-3-[6-(3-methylamino-phenyl)pyrid-3-yl]propanoate are obtained. • c- Methyl 2(S)-ethoxy-3-(6-{3-[methyl(4-nitrophenoxy-carbonyl)amino]phenyl}pyrid-3-yl)propanoate 70 mg {0.3 mmol) of 4-nitrophenyl chloro-formate and then 60 ul (0.3 mmol} of diisopropylethyl-amine are added to a solution of 70 mg (0.25 mmol) of methyl 2(S)-ethoxy-3-[6-(3-methylaminophenyl)pyrid-3-yl]propanoate in 3 ml of dichloromethane. The reaction medium is stirred at room temperature for 2 hours. After addition of water, the reaction medium is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and evaporated. 110 mg (100%) of methyl 2(S)-ethoxy-3-(6-(3- [methyl (4-nitrophenoxycarbonyl)amino]phenyl}pyrid-3-yl)propanoate are obtained. d- Methyl 2 (S)-ethoxy-3-{6-[3-(3-heptyl-l-methyl-ureido)phenyl]pyrid-3-yl}propanoate 70 ul (0.45 mmol) of heptylamine are added to a solution of 110 mg (0.25 mmol) of methyl 2{S)-ethoxy-3-(6-{3-[methyl(4-nitrophenoxycarbonyl) aminojphenyl}-pyrid-3-yl)propanoate in 3 ml of dimethylformamide. The reaction medium is heated at 80°C for 3 hours. After addition of water, the reaction medium is extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is purified by thin-layer chromatography on silica eluted with a 6/4 and then 5/5 heptane/ethyl acetate mixture. 50 mg (50%) of methyl 2(S)-ethoxy-3-{6-[3-(3-heptyl-l-methylureido)phenyl]pyrid-3-yl)propanoate are obtained. e- 2(S)-Ethoxy-3-{6-[3-(3-heptyl-l-methyiureido)-phenyl]pyrid-3-yl}propanoic acid In a manner similar to that of Example 20(i)r starting with 50 mg (0.1 mmol) of methyl 2(S)-ethoxy-3-{6-[3-(3-heptyl-l-methylureido)phenyl]pyrid-3-yl}-propanoate, 25 mg (50%) of 2(S)-ethoxy-3-{6-13-(3-heptyl-1-methylureido)phenyl]pyrid-3-yl}propanoic acid are obtained in the form of a white solid with a melting point of 140-141°C. 1H NMR (d, CDC13) : 0.87 (t, J = 6.7 Hz, 3H); 1.24 - 1.33 (m, 11H); 1.40-1.45 (m, 2H); 3.16-3.21 (m, 4H); 3.34 (a, 3H); 3.56-3.60 (m, 1H}; 3.69-3.73 (m, 1H); 4.17-4.20 (m, 1H); 4.40 (t, J = 5.2 Hz, 1H); 7.30-7.33 (m, 1H); 7.51-7.55 (m, 1H); 7.67-7.75 (m, 2H); 7.88-7.90 (m, 2H); 8.60 (d, J = 1.2 Hz, 1H). Example 24: 2 (S)-Btho3ty-3-{4-[6-(l-mat]iyl-3-pentqrl-ureido)pyrid-2-yl]phenyl}propanoio acid hydrodhlorido a- Methyl 2 (S)-et'hoxy-3-{4-[6-(l-methyl-3-pentyl-ureido)pyrid-2-yl]phenyl}propanoate a.l- Methyl 2(S)-ethoxy-3~{4-{6-[methyl(4-nitrophenoxycarbonyl) amino]pyrid-2-yl}phenyl)propanoate 0,96 g (4.8 mmol) of 4-nitrophenyl chloroformate and then 0.85 ml (4.8 mmol) of diisopropylethylamine are added to a solution of 1 g (3.2 mmol) of methyl 2(S)-ethoxy-3-[4-(6-methylaminopyrid-2-yl)phenyl]propanoate in 25 ml of dichloromethane. The reaction medium is stirred at room temperature for 1 hour 30 minutes. After addition of water and extraction with dichloromethane, the organic phase is dried over magnesium sulfate, filtered and evaporated. 1.9 g (100%) of methyl 2(S)-ethoxy-3-(4-{6-[methyl-(4-nitrophenoxycarbonyl)amino]pyrid-2-yl}phenyl}propanoate are obtained. a.2- Methyl 2(S)-ethoxy-3-{4-[6-(l-methyl-3-pentyl-ureido)pyrid-2-yl]phenyl}propanoate 0.65 g (1.1 mmol) of methyl 2(S)-ethoxy-3-(4-{6-[methyl-(4-nitrophenoxycarbonyl)amino]pyrid-2-yl}phenyl)propanoate, 12 ml of dimethylformamide and 1 ml (8.8 mmol) of pentylamine are heated at 80°C for 18 hours. After addition of water, the reaction medium is extracted with ethyl acetate. The ethyl acetate phase is dried over magnesium sulfate, filtered and evaporated. The. residue obtained is purified by thin-layer chromatography on silica eluted with a 7/3 and then 6/4 heptane/ethyl acetate mixture. 0.35 g (76%) of methyl 2(5)-ethoxy-3-{4-[6-(l-methyl-3-pentylureido)-pyrid-2-yl]phenyl}propanoate is obtained. b- 2(S)-Ethoxy-3-{4-[6~(l-methyl-3-pentylureido)pyrid-2-yl]phenyl}propanoic acid In a manner similar to that of Example 20(i), starting with 0.35 g (0.8 mmol) of methyl 2{S)-ethoxy-3-{4-[6-(l-methyl-3-pentylureido)pyrid-2-yl]phenyl}-propanoate, 300 mg (100%) of 2(S)-ethoxy-3-{4~[6-(1-methyl-3-pentylureido)pyrid-2-yl3phenyl}propanoic acid are obtained. c- 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-pentylureido)pyrid-2-yl]phenyl}propanoic acid hydrochloride In a manner similar to that of Example 10, starting with 300 mg of 2(S)-ethoxy-3-{4-[6-(l-methyl-3-pentylureido) pyrid-2-yl]phenyl}propanoic acid, 200 mg of 2(S)-ethoxy-3-{4-[6-{l-methyl-3-pentylureido)pyrid-2-yl] phenyl }propanoic acid hydrochloride are obtained in the form of a white solid. 1H NMR (d CDC13) : 0.84 (t, J = 6.9 Hz, 3H) ; 1.12 (t, J- 7.0 Hz, 3H); 1.29-1.34 (m, 4H); 1.63-1.66 (m, 2H); 3.04 (dd, J = 8.4 Hz, J = 14.0 Hz, 1H); 3.14 (dd, J 4.0 Hz, J = 14.0 Hz, 1H); 3.31-3.37 (m, 3H); 3.64- 3.70 (m, 4H); 4,01 (dd, J = 4.0 Hz, J = 8.4 Hz, 1H); 7.23 (d, J= 8.2 Hz, 1H); 7.45-7.47 (m, 3H) ; 7.70-7.71 (d, J = 8.2 Hz, 2H); 8.06 (t, J = 7.70 Hz, 1H). Exanple 25: 2 (S)-Ethoxy-3-{4-!:6- (l-methyl-3-butyl-ureido) pyrid-2-yl ] ph«nyl}propanoio aoid a- Methyl 2(S)-ethoxy-3-{4-[6-(l-methyl-3-butylureido) -pyrid-2-yl]phenyl}propanoate In a manner similar to that of Example 24(a), starting with 0.2 g (0.64 mmol) of methyl 2{S)-ethoxy-3-[4-(6-methylaminopyrid-2-yl)phenyl]propanoate, 0.2 g (80%) of methyl 2 (S)-ethoxy-3-{4-[6-(l-methyl-3-butylureido)pyrid-2-yl]phenyl}propanoate is obtained. b- 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-butylureido)pyrid-2-yl]phenyl}propanoic acid In a manner similar to that of Example 20 (i), starting with 0.2 g (0.5 mmol) of methyl 2(S)-ethoxy-3-{4-[6-(l-methyl-3-butylureido)pyrld-2-yl]phenyl}-propanoate, 130 mg (90%) of 2(S)-ethoxy-3-{4-[6-(1-methyl-3-butylureido)pyrid-2-yl]phenyl}propanoic acid are obtained in the form of a white solid. 1H NMR {d CDC13) : 0.92 {t, J - 7.3 Hz, 3H); 1.21 (t, J= 7.0 Hz, 3H); 1.35-1.45 (m, 2H); 1.57-1.64 (m, 2H); 3,11 (dd, J = 8.0 Hz, J - 14.1 Hz, 1H); 3.22 (dd, J - 4.0 Hz, J - 14.1 Hz, 1H}; 3.41 (q, J = 6.9 Hz, 2H); 3.47 (a, 3H); 3.48-3.50 (m, 1H): 3.67-3.71 (m, 1H); 4.15 (dd, J = 4.1 Hz; J- 8.0 Hz, 1H); 6.94 {d, J = 8.4 Hz, 1H); 7.36-7.41 {m, 3H); 7.75-7.82 (m, 3H)/ 10.5 {s, 1H). Example 26: 2 (S)-Ethoaey-3-{4-[6-(l-methyl-3-phenathyl-ureido)pyrid-2-yl]phenyl}propanoio acid, hydroohlorido a- Methyl 2(S)-ethoxy-3-{4-[6-(l-methyl-3-phenethyl-ureido)pyrid-2-yl]phenyl}propanoate In a manner similar to that of Example 24(a), starting with 0.63 g (1.1 mmol) of methyl 2 (S)-ethoxy-3-I4-(6-methylaminopyrid-2-yl)phenyl]propanoate, 0.4 g (83%) of methyl 2(S)-ethoxy-3-{4~[6-(l-methyl-3-phenethylureido)pyrid-2-yl]phenyllpropanoate is obtained. b- 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-phenethylureldo)-pyrid-2-yl]phenyl}propanoic acid In a manner similar to that of Example 20(i), starting with 0.4 g (0.8 mmol) of methyl 2(S)-ethoxy-3-{4-[6-(l-methyl-3-phenethylureido)pyrid-2-yl]phenyl}-propanoate, 300 rag (-85%) of 2 (S)-ethoxy-3-{4- [6-{l-methyl-3-phenethylure ido)pyrid-2-yl]phenyl}propano ic acid are obtained. c- 2(3)-Ethoxy~3-{4-[6-(l-methyl-3-phenethylureido)-pyrid-2-yl]phenyl}propanoic acid hydrochloride In a manner similar to that of Example 10, starting with 300 mg of 2(S)-ethoxy-3-{4-[6-(l-methyl-3-phenethylureido) pyrid-2-yl]phenylJpropanoic acid, 200 mg of 2(S)-ethoxy-3-{4-[6-(l-methyl-3-phenethylureido)pyrid-2-yl]phenyl}propanoic acid hydrochloride are obtained in the form of a white solid. 1H NMR (δ CDC13): 1.10 {t, J = 6.7 Hz, 3H) ? 2.85 (m, 2H); 2.94-3.04 (m, 1H); 3.10-3.13 (m, 1H); 3.31 (m, 1H); 3.60 (s, 3H); 3.62 (m, 2H); 3.66 (m, 1H); 3.98 {m, 1H); "7.09 (m, 1H) ; 7.19 (m, 5H) ; 7.38 {m, 3H) ; 7.59 {m, 2H); 7.97 (m, 1H) . Example 27: 2(S)-Bthoxy-3-{4~[6-{l-m«thyl-3-phenyl-ureido) pyrid-2-yl] phenyDpcopanoio acid a. Methyl 2(S)-ethoxy-3-{4-[6-(l-methyl-3-phenyl- ureido)pyrid-2-yl]phenyljpropanoate In a manner similar to that of Example 24(a>, starting with 0.63 g (1.1 mmol) of methyl 2{S)-ethoxy-3-[4-(6-methylaminopyrid-2-yl)phenyl]propanoate, 0.16 g (37%) of methyl 2(S)-ethoxy-3-{4-[6-(l-methyl-3-phenyl-ureido)pyrid-2-yl]phenyl}propanoate is obtained. b. 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-phenylureido)pyrid- 2-yl] phenyDpropanoic acid In a manner similar to that of Example 20 (i), starting with 0.16 g (0.8 mmol) of methyl 2(S)-ethoxy-3-{4-[6-(l-methyl-3-phenylureido)pyrid-2-yl]phenyl}-propanoate, 120 mg (92%) of 2(S)-ethoxy-3-{4-[6-(l-methyl-3-phenylureido) pyrid-2-yl]phenyDpropanoic acid are obtained. 1R NMR (δ CDC13) : 1.08 (t, J = 7.0 Hz, 3H) ; 2.97 (dd, J = 8.6 Hz, J - 14 Hz, 1H) ; 3.09 (dd, J - 4.1 Hz, J - 14.0 Hz, 1H); 3.28-3.32 (m, 1H); 3.44 (s, 3H); 3.59-3.64 {m, 1H); 3.97 (dd, J = 4.6 Hz, J - B.5 Hz, 1H); 6.94 (t, J = 7.4 Hz, 1H); 7.00 (d, J « 8.4 Hz, 1H); 7.18-7.22 (m, 2H); 7.37-7.39 (m, 3H) ; 7.43-7.45 {m, 2H); 7.78-7.82 (m, 3H); 13.00 (s, 1H). Example 28: 2(8)-Ethoxy-3-{4-[6-(l-m«thyl-3-naphthalen-2-yluroido)pyrid-2-yll phenyl }propanoia acid a. Methyl 2(S)-ethoxy-3-{4-[6-(l-roethyl-3-naphthalen-2- ylureido)pyrid-2-yl]phenyl}propanoat© In a manner similar to that of Example 7(i), starting with 0.4 g {0.8 nrniol) of methyl 2(S)-ethoxy-3-[4-(6-methylaminopyrid-2-yl)phenyl]propanoate and 2-naphthyl isocyanate, 0,2 g (62%) of methyl 2(S)-ethoxy-3-{4- [6-(l-methyl-3-naphthalen-2-ylureido)pyrid-2-yl ] phenyl }propionate is obtained.' b. 2(S)-Ethoxy-3-{4-[6-{l-methyl-3-naphthalen-2~yl- ureido)pyrid-2-yl]phenyl}propanoic acid In a manner similar to that of Example 20 (i), starting with 0.2 g .(0.5 mmol) of methyl 2 (S)-ethoxy-3-{4-[6-(l-methyl-3-naphthalen-2~ylureido)pyrid-2-yl]-phenyl}propanoate, 0.15 g (95%) of 2(S)-ethoxy-3-{4-[6-(l-methyl-3-naphthalen-2-ylureido)pyrid-2-yl]phenyl}-propanoic acid is obtained. 1H NMR (d CDC13) : 1.23 (t, J = 7.0 Hz, 3H) ; 3.16 (dd, J = 7.6 Hz, J - 14.1 Hz, 1H); 3.28 (dd, J - 4.3 Hz, J - 14.1 Hz, 1H); 3.52-3.56 (m, 1H) ; 3.58 (s, 3H); 3.68-3.72 (m, 1H) ; 4.21 (dd, J = 4.3 Hz, J - 7.6 Hz, 1H) ; 7.04 (d, J= 8.4 Hz, 1H); 7.28 (m, 1H); 7.37-7.51 (m, 5H); 7.75-7.84 (m, 4H); 7.92 (d, J- 8.2 Hz, 2H); 8.25 (d, J- 1.7 Hz, 1H); 13.30 (s, 1H). EXAMPLE 29 - CROSSOVER-CURVE BEAR TRAM3AMXVATION TOST The activation of PPAR receptors with an agonist (activator) in HeLN cells leads to the expression of a reporter gene, luciferase, which, in the presence of a substrate, generates light. The modulation of the PPAR receptors is measured by quantifying the luminescence produced after incubating the cells in the presence of a reference agonist. The ligands displace the agonist from its site. The measurement of the activity is performed by quantifying the light produced. This measurement makes it possible to determine the modulatory activity of the compounds according to the invention by determining the constant that represents the affinity of the molecule for the PPAR receptor. Since this value can fluctuate depending on the basal activity and the expression of the receptor, it is referred to as Kd apparent (KdApp in nM) . To determine this constant, "crossover curves" of the test product against a reference agonist are performed in a 96-well plate: 10 concentrations of the test product plus a concentration 0 are arranged in a line, and 7 concentrations of the agonist plus a concentration 0 are arranged in a column. This represents 88 measurement points for 1 product and 1 .receptor. The remaining 8 wells are used for repeatability controls. In each well, the cells are in contact with a concentration of the test product and a concentration of the reference agonist, 2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptylureido]ethyl}phenylaulfanyl)-2-methyl-propionic acid for PPARa, {2-methy1-4-[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-ylmethylsulfanyl]-phenoxy}acetic acid for PPARS and 5-{4-[2-(methylpyrid-2-ylamino}ethony]benzyl}thiazolidine-2,4-dione for PPARy. Measurements are also taken for total agonist controls with the same products. The HeLN cell lines used are stable transfectants containing the plasmids ERE-pGlob-Luc-SV-Neo (reporter gene) and PPAR (a, 5, Y) Gal-hPPAR. These cells are inoculated into 96-well plates at a rate of 10 000 cells per well in 100 pi of DMEM medium without phenol red and supplemented with 10% of defatted calf serum. The plates are then incubated at 37°C and 7% CO2 for 16 hours. The various dilutions of the test products and of the reference ligand are added at a rate of 5 pi per well. The plates are then incubated for 18 hours at 37°C and 7% C02. The culture medium is removed by turning over and 100 µl of a 1:1 PBS/luciferine mixture are added to each well. After 5 minutes, the plates are read by the luminescence detector. These crossed curves make it possible to determine the AC50 values (concentration at which 50% activation is observed) of the reference ligand at various concentrations of test product. These AC50 values are used to calculate the Schild regression by plotting a straight line corresponding to the Schild equation ("quantltatlon in receptor pharmacology" Terry P. Ksnakin, Receptors and Channels, 2001, J7, 371-365) which allows the Kd app values (in nM) to be obtained. Transactivation results: (Table Removed) n.a. means not active These results show the affinity of the compounds for PPAR- and more particularly the specificity of the affinity of the compounds of the invention for the PPARy subtype, compared with the affinity of the compounds for the PPARa subtype or for the PPAR5 subtype. EXAMPLE 30 - COMPOSITIONS Various concrete formulations based on the compounds according to the invention are illustrated in this example. A- ORAL ROUTE (a) 0.2 g tablet - Compound of Example 2 0.001 g - Starch 0.114 g - Dicalcium phosphate 0.020 g - Silica 0.020 g' - Lactose 0.030 g - Talc 0.010 g - Magnesium stearate 0.005 g (b) Drinkable suspension in 5 ml ampules - Compound of Example 4 0.001 g - Glycerol 0.500 g - 70% Sorbitol • 0.500 g - Sodium saccharinate 0.010 g - Methyl para-hydroxybenzoate 0.040 g - Flavouring qs - Purified water . qs 5 ml - Compound of Example 1 0.500 g - Pregelatinized starch 0.100 g - Microcrystalline cellulose 0.115 g - Lactose 0.075 g - Magnesium stearate 0.010 g (d) Drinkable suspension in 10 ml ampules - Compound of Example 10 0.200 g - Glycerol 1.000 g - 70% Sorbitol 1.000 g - Sodium aaccharinate 0.010 g - Methyl para-hydroxybenzoate 0.080 g - Flavouring qs - Purified water qs 10 ml B- TOPICAL ROUTE (a) Ointment - Compound of Example 8 0.020 g - Isopropyl myristate 81.700 g - Liquid petroleum Jelly fluid 9.100 g - Silica TAerosil 200" sold by 9.180 g Degussa) 5 (b) Ointment - Compound of Example 7 0.300 g - White petroleum jelly codex qs 100 g (c) Nonionic water-in-oil cream - Compound of Example 11 0.100 g - Mixture of emulsifying lanolin alcohols, waxes and oils ("Anhydrous Eucerin" sold by BDF) 39.900 g - Methyl para-hydroxybenzoate 0.075 g - Propyl para-hydroxybenzoate 0.075 g - Sterile demineralized water qa 100 g (d) Lotion - Compound of Example 6 0.100 g - Polyethylene glycol (PEG 400) 69.900 g - 95% Ethanol 30.000 g (e) Hydrophobia ointment - Compound of Example 15 0.300 g - Isopropyl myristate 36.400 g - Silicons oil PRhodorsil 47 V 300" sold by Rhone-Poulenc) 36.400 g - Beeswax 13.600 g - Silicone oil TAbil 300,000 cat" sold by Goldschmidt) qs 100 g (f) Nonionic oil-in-water cream - Compound of Example 9 1.000 g - Cetyl alcohol 4.000 g - Glyceryl monostearate 2.500 g - PEG-50 atearate 2.500 g - Karite butter 9.200 g - Propylene glycol 2.000 g - Methyl para-hydroxybenzoate 0.075 g - Propyl para-hydroxybenzoate 0.075 g - Sterile demineralized water qs 100 g We Claim 1. A compound which corresponds to formula (I) below: (Formula Removed) in which: - Rl represents a radical of formula (a) or (b) below: (Formula Removed) R3 and R4 having the meanings given below, - R2 represents an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, a 9-fluorenylmethyl radical or a radical of formula (CH2)m(NR5)n(C(0,N))pR6; R5, R6, m, n and p having the meanings given below; - R3 represents a radical chosen from the following formulae: (Formula Removed) R7, R8, V, W and Y having the meanings given below, - R4 represents an alkyl radical containing from 1 to 12 carbon atoms, a radical 0R9 or a radical SR9 or NHR9; - R5 and R7, which may be identical or different, represent a hydr-ogen atom, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl,radical or a heterocyclic radical; when Y represents an nitrogen atom, then formula (e) is not substituted by a radical R7; - R6 and R8, which may be identical or different, represent - a radical o- (CH2) v-R10, ~ a hydroxyl radical, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, or - a radical (Formula Removed) - a radical NR' (CH2)vR10, R10, R', R" and v having the meanings given below, - R9 represents an alkyl radical having from 1 to 12 carbon atoms or a radical chosen from the following formula: (f) (Formula Removed) (g) -CO-(Q)p-R11 or (h) α-amino acid N-protected with standard amine-protecting groups, such as 9-fluprenylmethylcarbamate (FMOC) , t-butylcarbamate (BOC) , benzyl or trifluoro-'acetyl; R11, Q and p having the meanings given below, - m may take the values 0, 1 or 2; - n and p may take the values 0 or 1; - Q represents an oxygen or sulfur atom or NR5; - V represents an oxygen, a nitrogen or sulfur atom; - W represents a nitrogen atom or a radical C-R5; - Y represents a nitrogen atom or a oarbon atom; - v may take the values 1, 2 or 3; - R10 represents an alkyl radical containing from 1 to 12 carbon atoms, an aryl, aralkyl, heteroaryl or heterocyclic radical, a radical NH-CO-R12, a radical NH-CO-0-R12 or C-R12R13 or a radical N-R12R13, R12 and R13 having the meanings given below; - R' represents a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, a heteroaryl radical or a heterocyclic radical; - R" represents a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, optionally substituted with one or more halogens, a heteroaryl radical, a heterocyclic radical, a radical (CH2)v-R10, or a radical NHR10 or NR10R10; - Rll represents a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical or a radical (CO) s (Z)tR10 with s and t possibly taking the values 0, 1 or 2; - Z represents an oxygen, nitrogen or sulfur atom; - R12 represents a hydrogen atom, an alkyl radical containing from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; - R13 represents a hydrogen atom or an alkyl radical containing from 1 to 12 carbon atoms; - X represents a bond having the following structure: (Formula Structure) D, w, z, T and R14 having the meanings given below; - T represents an oxygen or sulfur atom; - D represents an oxygen or sulfur atom, a radical -NR15 or a radical CH2; R15 having the meaning given below; - z takes a value of 0 or 1; - w takes a value from 0 to 6; and - R14 and R15 represent a hydrogen atom or an alkyl radical containing from 1 to 12 carbon atoms, - Arl and Ar2 are identical or different and represent a substituted or unsubstituted aromatic radical of formula: (Formula Removed) representing an S or 0 atom or a radical N-R13, with the -proviso that, when one of Arl and Ar2 is a phenyl radical, then the other of Ar2 and Arl is other than a phenyl radical, and the optical and geometrical isomers of the said compounds of formula (I), and also the salts thereof. 2. Compounds as claimed in Claim 1, which are in the form of a carboxylic acid salt, an organic amine salt or a salt of an amine function. 3. Compounds as claimed in Claim 2, which are in the form of an alkali metal or alkaline-earth metal salt, an amino acid salt, a salt of a halogen atom or an organic acid or nitrate salt. 4. Compounds as claimed in any one of the preceding claims, wherein the alkyl radicals containing from 1 to 12 carbon atoms are chosen from a linear or cyclic, saturated or unsaturated, branched or unbranched, hydrogen-containing or fluorine-containing radical containing 1 to 12 carbon atoms, which may be interrupted with a hetero atom, and the alkyl radicals containing from 1 to 12 carbon atoms are preferably methyl, ethyl, isopropyl, butyl, tert-butyl, hexyl, heptyl, octyl, decyl, cyclohexyl or methylenecyclopropyl radicals. 5. Compounds as claimed in any one of the preceding claims, wherein the aryl radical is chosen from a phenyl, biphenyl, cinnamyl or naphthyl radical, which may be mono- or disubstituted with a halogen atom, a CF3 radical, an alkyl radical containing from 1 to 12 carbon atoms, an alkoxy radical containing from 1 to 7 carbon atoms, a nitro function, a polyether radical, an aryl radical, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl radical optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at". least one alkyl containing from 1 to 12 carbon atoms. 6. Compounds as claimed in any one of the preceding claims, wherein the aralkyl radical is chosen from a benzyl, phenethyl or 2-naphthylmethyl radical, which may be mono- or disubstituted with a halogen atom, a CF3 radical, an alkyl radical containing from 1 to 12 carbon atoms, an alkoxy radical containing from 1 to 7 carbon atoms, a nitro function, a polyether radical, an aryl radical-, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl radical optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms. 7. Compounds as claimed in any one of the preceding claims, wherein the heteroaryl radical is chosen from the group consisting of an aryl radical interrupted with one or more hetero atoms, such as a pyridyl, furyl, thienyl, isoxazolyl, oxadiazolyl, oxazolyl, isothiazolyl, quinazolinyl, benzothia-diazolyl, benzimidazolyl, quinoxalyl, indolyl or benzofuryl radical, optionally substituted with at least one halogen, an alkyl containing from 1 to 12 carbon atoms, an alkoxy containing from 1 to 7 carbon atoms, an aryl radical, a nitro function, a polyether radical, a heteroaryl radical, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms. 8. Compounds as claimed in any one of the preceding claims, wherein the heterocyclic radical is chosen from the group consisting of a morpholino, piperidino, piperazino, 2-oxo-l-piperidyl or 2-oxo-l-pyrrolidinyl radical, optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms, an alkoxy containing from 1 to 7 carbon atoms, an aryl radical, a nitro function, a polyether radical, a heteroaryl radical, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at least one alkyl containing from 1 to 12 carbon atoms. 9. Compounds as claimed in any one of Claims 4 to 6, wherein the halogen atom is chosen from the group consisting of a fluorine atom, a chlorine atom and a bromine atom. 10. Compounds as claimed in Claim 1, wherein the compounds are selected from the group consisting of: N-{4- [4- (2, 4-Dioxothiazolidin-5-ylmethyl) phenyl] - thiophen- 2 -ylmethyl} -N-methylbenzamide; N-{5-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenyl]- thiophen-3-ylmethyl}-N-methylbenzamide; N-{5-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenyl]- pyrid-3-ylmethyl}-N-methylbenzamide; N-{3-[5-(2,4-Dioxothiazolidin-5-ylmethyl)pyrid-2- yl]benzyl}-N-methyloctanoylamide; 2(S)-Ethoxy-3-(4-{5-[(methyloctanoylamino)methyl]- thiophen-3-yl}phenyl)propanoic acid; 2 (S)-Ethoxy-3-(4-{5-[(methyloctanoylamino)methyl] -thiophen-2-yl}phenyl)propanoic acid; 2(S)-Ethoxy-3-{4-[2-(3-heptyl-l-methylureido)-thiazol-4-yl]phenyl{propanoic acid; 2(S)-Ethoxy-3-{4-[2-(3-pentyl-l-methylureido)-thiazol-5-yl]phenyl}propanoic acid ; 2 (S)-Ethoxy-3-{4-[6-(3-heptyl-l-methylureido)-pyrid-2-yl]phenyl)propanoic acid; 2- [4-(2-Carboxy-2(S)-ethoxyethyl)phenyl]-6- (3-heptyl-1-methylureido) pyridiniuiu chloride; 2 (S)-Ethoxy-3-(4-[5-(3-heptyl-l-methylureido)-2-methyl-2H- [1,2, 4] triazol-3-yl]phenyl)propanoic acid; {3-[5- (2,4-Dioxothiazolidin-5-ylmethyl)thiophen-2-yl]benzyl}methyloctanoylcarboxylamide; {3-[5-(2,4-Dioxothiazolidin-5-ylmethyl)thiophen-2-yl]benzyl}methylhexanoylcarboxylamide; 2 (S)- (2-Benzoylphenylamino)-3-(4-{5-[(methyloctanoylamino) methyl ]thiophen-3- yl{phenyl)propanoic acid; 2(S)-(2-Benzoylphenylamino)-3-(4-{5-[(hexanoyl- methylamino)methyl]thiophen-3-yl)phenyl)propanoic acid; 2(S)-Ethoxy-3-(4-{5-[(hexanoylmethylamino)- methyl]thiophen-3-yl}phenyl)propanoic acid; 2 (S)-Ethoxy-3-(4-{5-[(methylpentanoylamino)- methyl]thiophen-3-yl}phenyl)propanoic acid; 3-[4-(5-{[(2-Cyclopentylacetyl)methylamino]- methyl}thiophen-3-yl) phenyl] -2 (S) -ethoxypropanoic aciH ; 3- [4-(5-{ [ (3-Cyclohexylpropionyl)methylamino] -methyl}thiophen-3-yl) phenyl] -2 (S) -ethoxypropanoic acid; 2-Ethoxy-3- {6- [3- (3-heptyl-l-methylureido) phenyl] -pyrid-3-yl}propanoic acid; 2 (S)'- (2-Benzoylphenylamino) -3-{ 4- [6- (l-methyl-3-pentylureido)pyrid-2-yl]phenyl}propanoic acid; 2 (S) - (2-Benzoylphenylamino)-3-{4-[6-(3-heptyl-l-methylureido) pyrid-2-yl] phenyl} propanoic acid; 2 (S)-Ethoxy-3-{6-[3-(3-heptyl-l-methylureido)-phenyl]pyrid-3-yl}propanoic acid; 2 (S)-Ethoxy-3-{4-[6-(l-methyl-3-pentylureido) -pyrid-2-yl]phenyl}propanoic acid hydrochloride; 3-{4- [6-(3-Butyl-l-methylureido)pyrid-2-yl]-phenyl}-2(S)-ethoxypropanoic acid; 2 (S)-Ethoxy-3-{4-[6-(l-methyl-3-phenethylureido)-pyrid-2-yl]phenyl}propanoic acid hydrochloride; 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-phenylureido)-pyrid-2-yl]phenyl}propanoic acid; 2 (S)-Ethoxy-3-{4-[6-(l-methyl-3-naphthalen-2-ylureido) pyrid-2-yl]phenyl}propanoic acid; 3-{4-[6-(3-Cyclohexyl-l-methylureido)pyrid-2-yl]phenyl}-2(S)-ethoxypropanoic acid; 2 (S)-Ethoxy-3-{4-[3-(3-heptyl-l-methylureido)-phenyl]thiazol-2-yl}propanoic acid; 2 (S)-Ethoxy-3-{4-[3-(l-methyl-3-pentylureido)- phenyl]thiazol-2-yl}propanoic acid; 2 (S)-Ethoxy-3-{6-[3- (l-methyl-3-pentylureido) - phenyl]pyrid-3-yl}propanoic acid; 2 (S)-Ethoxy-3-[4-(6-{3-[2-(4-fluorophenyl) ethyl]- 1-methylureido}pyrid-2-yl)phenyl]propanoic acid; 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-pentylureido)- pyrid-2-yl]phenyl}propanoic acid; 2 (SJ-Ethoxy-3-{4-[4-(3-heptyl-l-methylureido)- pyrid-2-yl]phenyl}propanoic acid; 2 (S) -Ethoxy-3-{ 4- [4- (l-methyl-3-pentylureido) - pyrid-2-yl]phenyl}propanoic acid; 2 (S) -Ethoxy-3-{ 4- [2- (l-methyl-3-pentylureido) - pyrid-4-yl]phenyl}propanoic acid; 2 pyrid-4-yl]phenyl}propanoic acid; 2 (S)-Ethoxy-3-{4-[2-(3-heptyl-l-methylureido)- pyrimidin-4-yl]phenyl}propanoic acid; 2 (S) -Ethoxy-3-{ 4- [2- (l-methyl-3-pentylureido) - pyrimidin-4-yl]phenyl]propanoic acid; 2 (S)-Ethoxy-3-{5-[3-(3-heptyl-l-methylureido)- phenyl]furan-2-yl}propanoic acid; 2 (S)-Ethoxy-3-{5-[3-(3-heptyl-l-methylureido)- phenyl]thiophen-2-yl}propanoic acid; 2 (S)-Ethoxy-3-{2-[3-(3-heptyl-l-methylureido) - phenyl]pyrimidin-5-yl}propanoic acid; 2(S)-Ethoxy-3-{6-[3-(3-heptyl-l-methylureido)- phenyl]pyrid-3-yl}propanoic acid;" 2 (S)-Ethoxy-3-{4-[5-(3-heptyl-l-methylureido)- thiophen-2-yl]phenyl}propanoic acid; 2 (S) -Ethoxy-3-[4- (5-{ [methyl (6-propoxynaphthalene- 2-carbonyl) amino] methyl} f uxan-2-yl) phenyl] - propanoic acid; 2 (S) -Ethoxy-3-{4-[5- (3-heptyl-l-methylureido) - furan-2-yl]phenyl)propanoic acid; 2 (S) -Ethoxy-3-[4- (5-{ [methyl (6-propoxynaphthalene- 2-carbonyl) amino ] methyl }thiophen-2-yl") phenyl] - propanoic acid; 2 (S)-Ethoxy-3-[4-(4-{ [methyl(6-propoxynaphthalene-' 2-carbonyl) amino]methyl) thiophen-2-yl) phenyl] - propanoic acid; 3- (6-{ 3- [3- (4-Dimethylaminophenyl) -1-methyl- ureido]phenyl}pyrid-3-yl) -2 (S) -ethoxypropanoic acid; 2 (S)-Ethoxy-3-[6-(3-{ [methyl- (6-propoxy- naphthalene-2-carbonyl) amino] methyl}phenyl) pyrid- 3-yl]propanoic acid; 2 (S) -Ethoxy-3-{6-{3-[ (heptanoylmethy 1 amino) - methyl]phenyl}pyrid-3-yl)propanoic acid; 2 (S) -Ethoxy-3-(6-{3-[ (hexanoylmethylamino) methyl] - phenyl}pyrid-3-yl)propanoic acid; 2 (S) -Ethoxy-3-(4-{5- [ {methyloctanoylamino)methyl] - furan-2-yl)phenyl)propanoic acid; N-{3- [5- (3-Hydroxy-2 (S) -phenylaminobut-3-enyl) - pyrid-2-yl] benzyl} -N-methyloctanoylcarboxylamide; 2 (S)-Ethoxy-3-[6'-(3-heptyl-l-methylureido)- [2,2']bipyridyl-5-yl]propanoic acid; 1- (3-{2- [2 (S) -Ethoxy-3- (4-methylpiperid-l-yl) -3-oxopropyl] thiazol-4-yl}phenyl) -l-m.ethyl-3-pentyl-urea; 1- (3-{ 5- [2 (S) -Ethoxy-2- (5-propyl- [1, 3, 4] oxadiazol-2-yl) ethyl]pyrimidin-2-yl)phenyl) -3-heptyl-l-methylurea; l-{6-[4- (2 (S) -Ethoxy-3-oxo-3-piperid-l-ylpropyl) -phenyl ]pyrid-2-yl}-l-methyl-3-pentyilurea; l-(6-{4-[2(S)-Ethoxy-3-(4-methylpiperid-l-yl)-3-oxopropyl] phenyl }pyrid-2-yl) -l-m.ethyl-3-pentylurea; l-{6-[4-(2 (S)-Ethoxy-3-morpholin-4-yl-3-oxo-propyl] phenyl] pyrid-2-yl} -l-methyl-3-pentylurea; 2 (S)-Ethoxy-3-(4-{5-[ (hexanoylmethylamino)methyl] -thiophen-3-yl}phenyl)propanoic acid; { 4- [4- (2 (S) -Ethoxy-3-oxo-3-piperid-l-ylpropyl) -phenyl] thiophen-2-ylmethyl}methylhexanoylcarboxyl-amide; (4-{4-[2 (S)-Ethoxy-3-(4-methylpiperid-l-yl)-3-oxopropyl] phenyl} thiophen-2-ylmethyl)methyl-hexanoylcarboxylamide; { 4- [4- (2 (S) -Ethoxy-3-morpholin-4-yl-3-oxopropyl) -. phenyl] thiophen-2-ylmethyl}methylhexanoylcarboxyl-amide;" {4- [4-(2 (S)-Ethoxy-3-oxo-3-piperid-l-ylpropyl)-phenyl] thiophen-2-ylmethyl }methyloctanoylcarboxyl-amide;' (4-{4~[2(S)-Ethoxy-3-(4-methylpiperid-1-yl)-3-oxopropyl]phenyl}thiophen-2-ylmethyl)methyl- octanoylcarboxylartu.de; l-{3-[5-(2 (S)-Ethoxy-3-oxo-3-piperid-l-ylpropyl)- pyrid-2-yl]phenyl}-l-methyl-3-pentylurea; 1- (3-{5- [2 (S)-Ethoxy-3-(4-methylpiperid-l-yl)-3- oxopropyl]pyrid-2-yl}phenyl) -l-methyl-3-pentylurea; l-{3-[5-(2(S)-Ethoxy-3-morpholin-4-yl-3-oxo- propyl) pyrid-2-yl] phenyl} -l-methyl-3-pen.tylurea;" l-{3-[2-(2,4-Dioxothiazolidin-5-ylmethyl)- pyrimidin-5-yl ] phenyl} -3-heptyl-l-methylurea; l-{3-[2-(2,4-Dioxothiazolidin-5-ylmethyl)- pyrimidin-5-yl] phenyl} -l-methyl-3-pentylurea; 2(S)-Ethoxy-3-{5-[3-(l-methyl-3-pentylureido)- phenyl]pyrimidin-2-yl}propanoic acid;" 2(S)-Ethoxy-3-{6-[4-fluoro-3-(l-methyl-3-pentyl- ureido)phenyl]pyrid-3-yl}propanoic acid; 2(S)-Ethoxy-3-{2-fluoro-4-[6-(l-methyl-3-pentyl- ureido)pyrid-2-yl]phenyl}propanoic acid; 2(S)-Ethoxy-3-{4-[5-(l-methyl-3-pentylureido)- thiophen-2-yl]phenylJpropanoic acid; 2(S)-Ethoxy-3-{4-[5-(3-heptyl-l-methylureido)- thiophen-2-yl]phenyl]propanoic acid; 2(S)-Methylamino-3-(4-(5-[ (methyloctanoylamino)- methyl]thiophen-3-yl}phenyl)propanoic acid; 2(S)-Ethylamino-3-(4-{5-[(methyloctanoylamino)- methyl]thiophen-3-yl}phenyl)propanoic acid; 2 (S)-Ethylamino-3- (4-{5-[(hexanoylmethylaitd.no) - methyl]thiophen-3-yl}phenyl)propanoic acid; 3- (4-{5- [ (Hexanoylmethylamino)methyl]thiophen-3- yl}phenyl)-2(S)-methylaminopropanoic acid; 2 (S)-Ethylamino-3-{4-[6-(l-methyl-3-pentylureido)- pyrid-2-yl]phenyl}propanoic acid; 2 (S)-Ethylamino-3-{4-[6-(3-heptyl-l-methylureido)- pyrid-2-yl]phenyl}propanoic acid; 3-{4-[6-(3-Heptyl-l-methylureido)pyrid-2-yl]- phenyl}-2 (S) -methylaminopropanoic acid;' 2{S)-Methylamino-3-{4-[6-(l-methyl-3-pentyl- ureido) pyrid-2-yl] phenyl} propanoic acid;' 2(S)-Cyclopropylmethoxy-3-{4-[6-(l-methyl-3- pentylureido)pyrid-2-yl]phenyl}propanoic acid; 2(S)-Ethoxy-3-[6'-(l-methyl-3-pentylureido) - [2,2' ]bipyridyl-5-yl]propanoic acid; 2 (S) -Ethoxy-3- (6-{5- [ (methyloctanoylamino)methyl] - thiophen-3-yl}pyrid-3-yl)propanoic acid; 2 (S) -Ethoxy-3- (6-{5- [ (hexanoylmethylamino)methyl]- thiophen-3-yl}pyrid-3-yl)propanoic acid; 2-[4-(2-Carboxy-2(S)-eth6xyethyl)phenyl]-6- (3- heptyl-1-methylureido)pyridinium fumarate; 2-[4- (2-Carboxy-2(S)-ethoxyethyl)phenyl]-6-(3- heptyl-l-methylureido)pyridinium maleate; 3-{4-[6-(l-Methyl-3-pentylureido)pyrid-2-yl]- phenyl}-2(S)-propoxypropanoic acid; 2 (S)-Isopropoxy-3-{4-[6-(l-methyl-3-pentylureido)- pyrid-2-yl]phenyl}propanoic acid; 2(S)-Ethoxy-3-[4-(5-{[(3-lH-indol-3-ylpropionyl)- methylamino]methyl}thiophen-3-yl) phenyl]propanoic acid; 3-{4-[6-(3-Pentyl-l-methylureido)pyrid-2-yl]- phenyl}-2-methylpropanoic acid; 3-{4- [6- (3-Heptyl-l-methylureido)pyrid-2-yl]- phenyl)-2-methylpropanoic acid; 2-Methyl-3-(4-{5-[(methyloctanoylamino)methyl]- thiophen-2-yl}phenyl)propanoic acid; 3-{6-[3-(3-Heptyl-l-methylureido) phenyl]pyrid-3- yl}-2-methylpropanoic acid; 2(S)-Ethoxy-3-(4-{4-[l-methyl-3-(2-piperidin-l-yl- ethyl)-ureido] -.pyridin-2-yl}-phenyl) -propanoic; 2 (S)-Ethoxy-3- (4-{4-[l-methyl-3-(3-phenyl-propyl)-ureido]-pyridin-2-yl}-phenyl) -propanoic acid; 2 (S)-Ethoxy-3-(4-{4-[l-methyl-3-(4-phenyl-butyl)-ureido]-pyridin-2-yl}-phenyl) -propanoic acid; 3-{4- [4-(3-Benzo[l,2,5]thiadiazol-4-yl-l-methyl-ureido)-pyridin-2-yl]-phenyl}-2(S)-ethoxy-propanoic acid; 3- (4-{4- [3- (4-Dimethylamino-phenyl) -1-methyl-ureido ]-pyridin-2-yl} -phenyl) -2(S)-ethoxy-propanoic acid; 2(S)-Ethoxy-3-[4-(4-{3-[2-(lH-imidazol-2-yl)-ethyl]-1-methyl-ureido}-pyridin-2-yl)-phenyl]-propanoic acid; 3-(4-{4-[3-(2-Dimethylamino-ethyl)-1-methyl-ureido] -pyridin-2-yl}-phenyl)-2(S)-ethoxy-propanoic acid; 2(S)-Ethoxy-3-{4-[4-(l-methyl~3-naphthale.n-2-yl-ureido)-pyridin-2-yl]-phenyl)-propanoic acid; 3-{4-[6-(3-Benzo[1,2,5]thiadiazol-4-yl-l-methyl-ureido)-pyridin-2-yl]-phenyl}-2(S)-ethoxy-propanoic acid; 2 (S.) -Ethoxy-3- (4-{6- [l-methyl-3- (3-phenyl-propyl) -ureido]-pyridin-2-yl}-phenyl) -propanoic acid; 2 (S) -Ethoxy-3-(4-{6- [l-methyl-3- (2-piperidin-l-yl-ethyl) -ureido] -pyridin-2-yl} -phenyl) -propanoic acid;' 2 (S)-Ethoxy-3-(4-{6-[l-methyl-3-(4-phenyl-butyl)-ureido]-pyridin-2-yl}-phenyl)-propanoic acid; 3- (4-{6- [3- (4-Dimethylamino-phenyl) -1-methyl-ureido]-pyridin-2-yl}-phenyl)-2(S)-ethoxy-propanoic acid; 3- (4-{ 6- [3- (2-Dimethylaraino-ethyl) -1-methyl-ureido]-pyridin-2-yl}-phenyl)-2(S)-ethoxy-propanoic acid; 2(S)-Ethoxy-3-[4-(6-{3-[2-(lH-imidazol-2-yl)-ethyl]-l-methyl-ureido}-pyridin-2-yl)-phenyl]-propanoic acid; 2(S)-Ethoxy-3-{4-[6-(l-methyl-3-pentyl-thioureido)-pyridin-2-yl]-phenyl}-propanoic acid; 2(S)-Ethoxy-3-(4-[6-(l-methyl-3-heptyl-thioureido)-pyridin-2-yl]-phenyl}-propanoic acid; 2(S)-Ethoxy-3-{6-[3-(3-heptyl-l-methyl-thioureido)-phenyl]-pyridin-3-y1}-propanoic acid; 2(S)-Ethoxy-3-{4-[4-(3-heptyl-l-methyl-thioureido)-pyridin-2-yl]-phenyl}-propanoic acid; 2 (S) -Ethoxy-3- (6-{ 3- [l-methyl-3-(2-piperidin-l-yl-ethyl)-ureido]-phenyl }-pyridin-3-yl) -propanoic acid; 3-(6-{3-[3-(2-Benzo[l,2,5]thiadiazol-4-yl-ethyl)-1-methyl-ureido]-phenyl}-pyridin-3-yl)-2 (S) -ethoxy-propanoic acid; 2 (S)-Ethoxy-3-(6-{3-[l-methyl-3-(3-phenyl-propyl)-ureido]-phenyl}-pyridin-3-yl)-propanoic acid; and 3- (6-{3-[3-(4-Dimethylamino-phenyl )-l-methyl-ureido]-phenyl}-pyridin-3-yl)-2(S)-ethoxy-propanoic acid. 11. Compounds as claimed in any one of the preceding claims, wherein: Rl represents a radical of formula (a) or (b); in the case where Rl corresponds to formula (b), R3 is preferably a radical of formula (d) with R8 being a hydroxyl, NR'R" or heterocyclic radical and R4 preferably being a radical of formula OR9 in which R9 is an alkyl of 1 to 12 carbon atoms or a group of formula (f) with Rll being a hydrogen or a group COOR10; and/or R2 represents an alkyl, aryl or heteroaryl radical; and/or X represents the bond of structure -CH2N(R14)CO- or N(R14)-CO-(D) w- with w = 0 or 1; and/or Arl or Ar2 contain at least one group of pyridine, thiazole, pyrimidine, thiophene or triazole type. 12. A compound as claimed in any one of the preceding claims, whenever used for the preparation of a pharmaceutical composition.

Documents:

5861-DELNP-2005-Abstract-(08-10-2009).pdf

5861-DELNP-2005-Abstract-(17-08-2009).pdf

5861-delnp-2005-abstract.pdf

5861-DELNP-2005-Claims-(08-10-2009).pdf

5861-DELNP-2005-Claims-(17-08-2009).pdf

5861-delnp-2005-claims.pdf

5861-DELNP-2005-Correspondence-Others (5-10-2009).pdf

5861-DELNP-2005-Correspondence-Others-(08-10-2009).pdf

5861-DELNP-2005-Correspondence-Others-(09-12-2009).pdf

5861-DELNP-2005-Correspondence-Others-(17-08-2009).pdf

5861-delnp-2005-correspondence-others.pdf

5861-DELNP-2005-Description (Complete)-(08-10-2009).pdf

5861-DELNP-2005-Description (Complete)-(17-08-2009).pdf

5861-delnp-2005-description (complete).pdf

5861-DELNP-2005-Drawings-(17-08-2009).pdf

5861-delnp-2005-drawings.pdf

5861-DELNP-2005-Form-1-(08-10-2009).pdf

5861-DELNP-2005-Form-1-(17-08-2009).pdf

5861-delnp-2005-form-1.pdf

5861-delnp-2005-form-18.pdf

5861-DELNP-2005-Form-2-(08-10-2009).pdf

5861-DELNP-2005-Form-2-(17-08-2009).pdf

5861-delnp-2005-form-2.pdf

5861-delnp-2005-form-26.pdf

5861-DELNP-2005-Form-3-(09-12-2009).pdf

5861-DELNP-2005-Form-3-(17-08-2009).pdf

5861-delnp-2005-form-3.pdf

5861-delnp-2005-form-5.pdf

5861-DELNP-2005-GPA (5-10-2009).pdf

5861-delnp-2005-pct-210.pdf

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