Title of Invention

"PROCESS FOR PREPARING 4,5,6-TRIFLUOROPYRIDIMINE, 1,3,5-TRIFLUOROBENEZENE OR 3,4,5-TRIFLUOROBENZOTRIFLUORIDE''

Abstract "PROCBSS FOR PREPARING 4,5,6-TRIFLUOROPyRIDIMINE, 1,3,5-TRIFLUOROBENEZENE OR 3,4,5-TRIFLUOROBENZOTRIFLUORIDE'' Process for preparing 4,5,6-trifluoropyridiinine, 1,3,5-trifluorobenezene or 3,4,5-trifluorobenzotrifluoride, by reacting 4,5,6-trichloropyridimine, 1,3,5-trichlorobenezene or 3,4,5-trichlorobenzotrifluoride, with a fluoride in the presence of at least one compound of the structure (III-l)or(III-2) characterized in that the reaction in effected in one stage.
Full Text The present invention relates to a process for preparing 4,5,6-trifluoropyridimine, l,3,5-trifluorobene2ene or 3,4,5-trifluorobenzotrifluoride.
The present invention relates to an improved process for preparing ring-fluorinated aromatics by a halogen exchange reaction (halex reaction) of a plurality of halogen substituents in one stage in the presence of a catalyst.
Ring-fluorinated aromatics are important intermediates for preparing biologically active substances for pharmaceutical and agrochemical applications.
It is known to carry out halex reactions in aprotic, strongly polar solvents using metal fluorides at elevated temperature and in the presence of alkylammonium or alkylphosphonium salts (US-A 4 287 374), pyridinium salts (WO 87/04149), crown ethers (DE-A 197 02 282) or tetraamidophosphonium salts (WO 98/05610). A disadvantage of such reactions is, especially when weakly activated aromatics are used, the required high reaction temperatures and long reaction times. This leads to high energy consumptions and low space-time yields. The high reaction temperatures frequently lead to the formation of undesired by-products and decomposition products. In addition, large amounts of expensive solvents are required.
In particular, the exchange of a plurality of halogen substituents of weakly activated aromatics has to date generally presented problems.
For example, it is known from EP-A 1 266 904 to subject aromatic compounds which are substituted with halogen on the ring to a halex reaction with a fluoride and at temperatures between 40 and 260°C and in the presence of a specific catalyst However, a disadvantage of this reaction is that especially an exchange of two and more halogen atoms in the case of weakly activated aromatics, for example tetrafluorobenzotrifluoride, necessitates an at least two-stage reaction in order to keep the amount of fluoride and solvent low. Such a two-stage or multistage reaction leads not only to yield losses owing to the isolation of the intermediates but also to a relatively high level of process complexity. In 3,4-dichlorobenzonitrile, the exchange of only one chlorine substituent for fluorine is actually selective.


The preparation of 4,5,6-trifluoropyridimine by means of halex reaction has also only been described to date in the literature via the intermediate stage of 5-chloro-4,6-dipyrimidine (DE-A 196 02 095), which is in turn prepared by halex reaction from 4,5,6-tnchloropyrimidine.
The exceptionally weakly activated aromatic 1,3,5-trichlorobenzene can be convened by halex reaction to 1,3,5-trichlorofluorobenzene only at temperatures of above 300°C, but a realization on the industrial scale is very costly and inconvenient and leads at these temperatures to considerable materials problems, for example stress-cracking corrosion in the case of metal tanks.
Attempts to prepare 1,3,5-trifluorobenzene starting from 1,3,5-trichlorobenzene at relatively low temperatures lead either to no formation of the desired product whatsoever (WO-A 02/092226) or only to small yields of not more than 14% (WO-A 02/092608).
Also in the case of the reaction of the weakly activated 3,4,5-trichlorobenzo-trifluonde with KF, in addition to 3-chloro-4,5-difluorobenzotrifluoride as the main component, 3,4,5-trifluorobenzotrifluoride is formed merely as a by-product in a yield of distinctly below 10%.
There is thus still a need for a reaction suitable for exchanging two or more halogen substituents of weakly activated aromatics for fluorine substituents in a halex reaction, which does not have the above-detailed disadvantages of known processes and affords the corresponding ring-fluorinated aromatics in good yield.
The object on which the present invention is based is thus to provide a technically less complicated process for preparing ring-fluorinated aromatics by halogen exchange reaction (halex reaction) in good yield.
It has now been found that, surprisingly, doubly or multiply ring-fluorinated aromatics can be obtained in good yield when two or more halogen substituents in

correspondingly doubly or multiply ring-halogenated weakly activated aromatics are exchanged in the presence of specific catalysts in only one reaction step.
The present invention therefore provides a process for preparing a compound of the general formula (I)
(Figure Removed)
in which
A is N or CH,
D is N or CH,
E is N, CH, C-CF3, C-CN or CF and
X' is H, CN or F, preferably H or F,
with the proviso that A, D and E do not all simultaneously have the same definition, and preferably are not all simultaneously N or not all simultaneously CH,
by reacting a compound of the general formula (II)
(Figure Removed)
in which
A is N or CH, D is N or CH,
E is N, CH, C-CF3, C-CN or C-Hal,
X2 is H, Cl, Br, I or CN, preferably H, Cl, Br or CN, more preferably H or Cl, and
Hal is Cl, Br or I, preferably Cl or Br, more preferably Cl,
-4-
with the proviso that A, D and E do not all simultaneously have the same definition and are preferably not all simultaneously N or not all simultaneously CH,
with a fluoride in the presence of at least one compound of the general formula (III)
(Formula Removed)
the individual R1 are the same or different and are each straight-chain or branched Ci-Cio-alkyl, straight-chain or branched C2-C10-alkylene or C6-C12-aryl,
where one or more NR1R1 groups may also be a 3- to 5-membered, saturated or unsaturated ring which is formed from one nitrogen atom and otherwise carbon atoms,
where the formula (IV) and the
group in formula (Via) may also be a radical of a saturated or unsaturated 4- to 8-membered ring which contains two nitrogen atoms and otherwise carbon atoms, X is N or P and Anθ i s one equivalent of an anion, characterized in that the reaction is effected in one stage.
In the context of the invention, a one-stage reaction means that there is no isolation or workup of partly fluorinated intermediates in the reaction.
The process according to the invention is preferably suitable for preparing compounds of the general formula (I) from compounds of the general formula (II) in which
A and D are each N and E is CH, C-CF3 or C-CN, or A and D are each CH and E is N, C-CF3 or C-CN, or A is N, D is CH and E is C-CF3, or
A and D are each CH and E is CF in the general formula (I) and is C-Hal in the general formula (II), where Hal is as defined above for the general formula (II).
The process according to the invention is more preferably suitable for preparing 3,5-difluoropyridine, 4,5,6-trifluoropyrimidine, 1,3,5-trifiuorobenzene or 3,4,5-trifluoro-benzotrifluoride, in particular for preparing 4,5,6-trifluoropyrimidine, 1,3,5-trifiuorobenzene or 3,4,5-trifluorobenzotrifluoride. The compounds of the general formula (II) used for this purpose are more preferably 3,5-dichloropyridine, 4,5,6-trichloropynmidine, 1,3,5-trichlorobenzene or 3,4,5-trichlorobenzotrifluoride, in particular 4,5,6-trichloropyrimidine, 1,3,5-trichlorobenzene or 3,4,5-trichlorobenzotri fluoride.
The compounds of the general formula (II) used in the process according to the invention are weakly activated aromatics, i.e. aromatics which have a moderately electron-withdrawing group in the meta-(m-)position to at least one, preferably to at least two, of the halogen substituents to be exchanged. In the context of the invention, moderately electron-withdrawing groups, taking into account the preferable meta-arrangement with respect to at least one, preferably to at least two, of the halogens to be exchanged, are in particular nitrogen atoms in the aromatic ring and also halogen, CF3 or CN substituents on a ring carbon atom, where halogen may either be Cl, Br or I, or already exchanged F.
The two R1 radicals bonded to the same nitrogen atom in the general formulae (IV), (V), (Vl-a) and (Vl-b) are preferably identical.
The R1 radicals are preferably methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl or tert-butyl, preferably methyl, ethyl, n-propyl or n-butyl, or an NR'R1 group is a 5-to 7-membered, saturated or unsaturated ring which is formed from one nitrogen atom and otherwise carbon atoms,
or the formula (IV) or the
IMPS r\ group m formula (Via) is a saturated 5- to 7-membered ring
which contains 2 nitrogen atoms and otherwise carbon atoms, X is nitrogen and
Ane is chloride, bromide, (CH3)3SiF2e, HFe, H2F2e, tetrafluoroborate, hexafluorophosphate, carbonate or sulphate.
Particularly preferred compounds of the general formula (III) are compounds of the formulae (III- 1) to (III-6)

(Formula Removed)
Useful fluorides for the exchange of halogen for fluorine are, for example, alkali metal, alkaline earth metal and ammonium fluorides. Preference is given to potassium fluoride, sodium fluoride, calcium fluoride and ammonium fluoride, and also to their mixtures with one another and to their mixtures with lithium fluoride, rubidium fluoride and/or caesium fluoride.
Based on 1 mol of halogen which is bonded to the ring of an aromatic compound and is to be exchanged for fluorine, for example, 0.001 to 0.5 mol, preferably 0.01 to 0.1 mol, of one or more compounds of the formula (III) and, for example, 0.8 to 2 equivalents, preferably 1.1 to 1.5 equivalents, of one or more halides can be used.
The compound(s) of the general formula (III) may be used in isolated form or in the form of solutions. Suitable solvents are, for example, dipolar aprotic and/or nonpolar aprotic solvents.
The process according to the invention is carried out preferably at temperatures in the range of 40 to 260°C, more preferably at 70 to 240°C. Very particular preference is given to 160to220°C.
The process according to the invention can be carried out in the presence or in the absence of solvents. Preference is given to carrying out the process according to the invention in the presence of at least one solvent. Suitable solvents include, for example, dipolar aprotic and/or nonpolar aprotic solvents. Suitable dipolar aprotic solvents are, for example, dimethyl sulphoxide, sulpholane, dimethylformamide, dimethylacetamide, l,3-dimethylimidazolin-2-one, N-methylpyrrolidone, acetonitrile and benzonitrile. Suitable nonpolar aprotic solvents are, for example, benzene, toluene, chlorobenzene, dichlorobenzenes, chlorotoluenes and chloroalkanes such as dichloromethane. The above-listed solvents are likewise suitable for the solutions of the compound(s) of the general formula (III).
Nonpolar aprotic and dipolar aprotic solvents can be used in any amounts, for example in amounts of 0.1 to 500% by weight, preferably in amounts of 0.2 to 300% by weight, based in each case on the aromatic compound used, which is substituted by halogen exchangeable for fluorine.
It is also possible to use mixtures of solvents, preference being given to using solvent mixtures which comprise 50% by weight or more dipolar aprotic solvents.
It is also possible to carry out the process according to the invention in the presence or in the absence of free-radical scavengers. Suitable free-radical scavengers are, for example, aromatic nitro compounds, preferably nitrobenzene, 3-nitrodimethyl-benzamide or 1,3 -dinitrobenzene, more preferably nitrobenzene or 3-nitrodimethyl-benzamide. The free-radical scavengers may be used in an amount of up to 10 mol% based on the amount of the compound of the general formula (II). The use of free-radical scavengers allows the formation of by-products by dehalogenation to be distinctly reduced.
The reaction time in the process according to the invention may, for example, be in the range of 2 to 48 hours.
The process according to the invention may be carried out at reduced, standard or elevated pressure. Preference is given to working at standard pressure or elevated pressure, for example at 1 to 16 bar, more preferably at 2 to 10 bar.
In principle, the compounds of the formula (I) may be handled in the presence or absence of atmospheric oxygen. However, preference is given to handling the compounds of the formula (I) under protective gas and to carrying out the process according to the invention under protective gas. Suitable protective gases are, for example, nitrogen and argon.
The process according to the invention can be carried out batchwise or continuously.
To work up the reaction mixture present after the process according to the invention has been carried out, the procedure may be, for example, to mix the reaction mixture, after cooling, with water, remove the organic phase which forms and fractionally distil the removed organic phase under reduced pressure. The reaction mixture present after the process according to the invention has been carried out may also be subjected directly to a distillation. In addition, it is possible to add a solvent to the reaction mixture, remove solid constituents by filtration and distil the filtrate under reduced pressure. Furthermore, the product of the general formula (I) may also be
removed from the reaction mixture by means of distillation under reduced pressure (pressure distillation). Other workup means can also be employed.
The preparation of the catalysts of the general formula (III) is known and is described, for example, in Synthesis 1979, 215-216, Angewandte Chemie 104, 864, 1992 or EP-A 1 266 904. In some cases, it has been observed that, in the preparation of compounds of the formula (III), mixtures of two or more individual compounds which correspond to the formula (III) are obtained. Such mixtures are also suitable as catalysts for the process according to the invention.
The process according to the invention for preparing doubly or multiply ring-fluorinated aromatics proceeds, in comparison to known processes, in one stage and thus entails, compared to the prior art, a lower level of process technology complexity with regard to materials, energy and tank lining. In addition, the target products can be obtained with at least comparable, usually higher yield compared to the prior art. The process according to the invention is therefore a distinctly improved process compared to the prior art.
The examples which follow serve to illustrate the invention by way of example and are not to be interpreted as a restriction.
(Formula Removed)
600 ml of toluene were initially charged and 360 g of phosgene were added at room temperature (23°C) within 3.5 h. Subsequently, 344 g (3.00 mol) of 1,3-dimethylimidazolidinone in 450 ml of toluene were added within 1.5 h, in the course of which the temperature was kept at 40°C. After the gas evolution had ended, excess phosgene was removed by bubbling it out with nitrogen. The suspension is filtered under inert gas and 438 g (2.56 mol) of (N,N-dimethylimidazolidino) chloride are obtained as a colourless solid. Yield: 85%. m.p.: 156-158°C.
600 ml of dichloromethane and 400 g (2.34 mol) of (N,N-dimethylimidazolidino) chloride are initially charged. Subsequently, 552 g of tetramethylguanidine (2 eq., 4.8 mol) are added with cooling within 2 hours. Subsequently, the solvent is removed and 600 ml of methanol are added to the solid residue. Afterwards, 432 g (2.4 mol) of 30% sodium methoxide solution (in methanol) are added to the suspension with cooling and the mixture is stirred at room temperature for one hour. The solvents are removed and 200 ml of dichloromethane are then added to the residue. The precipitate is filtered off and discarded. The filtrate is concentrated to dryness. 449 g (1.80 mol) of (N,N-dimethylimidazolidino)tetramethylguanidinium chloride (CNC catalyst of the formula (III-l)) are isolated. Yield: 94%; m.p.: 145-147°C.
Example 1: Preparation of 3,5-difluoropyridine

1000 g of dichloropyridine and 1580 g of dry potassium fluoride were initially charged in 1700 ml of sulpholane in an autoclave. Subsequently, 84 g of CNC catalyst (compound (III-l)) were added, nitrogen was injected to 3 bar and the mixture was heated to 205°C with stirring for 48 h. During the reaction, a maximum total pressure of 12.4 bar arose. Subsequently, the mixture was cooled to 10°C and the product was distilled off at standard pressure. After redistillation, 473 g of dichloropyridine (60% of theory) were obtained as a colourless liquid.
Example 2: Preparation of 4,5,6-trifluoropyrimidine
(Figure Removed)
7160 ml of sulpholane and 3876 g of KF were initially charged in an autoclave and stirred at 150°C for 1 h. Subsequently, the mixture was dried by distilling off 700 ml of sulpholane under reduced pressure. The mixture was then cooled to 90°C and aerated with nitrogen, and a solution, heated to 45°C, of 3122 g of 4,5,6-trichloro-pyrimidine and 2386 g of dry sulpholane was pumped in. Afterwards, 166 g of CNC catalyst and 20.5 g of nitrobenzene were added rapidly and the vessel was sealed. The mixture was heated to 200°C with stirring for 5 h and subsequently to 220°C for 11 h. During the reaction, a maximum total pressure of 6.5 bar arose. The mixture was cooled to 40°C with stirring and decompressed slowly into an ice-cooled receiver. The internal temperature was increased slowly to 150°C and the product was distilled off initially at standard pressure, later under reduced pressure. After redistillation of the crude product, 1540 g of 4,5,6-trifluoropyrimidine (66% of theory) were obtained as a colourless liquid.
Example 3: Preparation method of 3,4,5-trifluorobenzotrifluoride

(Figure Removed)


860 g of dry sulpholane and 524 g of dry KF were initially charged with exclusion of moisture in an autoclave, and 500 g of 3,4,5-trichlorobenzotrifluoride, 5 g of nitrobenzene and 25 g of CNC catalyst were added. The vessel was sealed and the mixture subsequently heated to 200°C for 5 h and then to 220°C for a further 12 h. During the reaction, a maximum total pressure of 9 bar arose. The mixture was then cooled to 20°C and decompressed into a cooled receiver. The product was distilled off at standard pressure. After redistillation of the crude product, 300 g of 3,4,5-trifluorobenzotrifluoride (75% of theory) were obtained as a colourless liquid.
Example 4: Preparation method of 1,3,5-trifluorobenzene
(Figure Removed)

500 g of 1,3,5-trichlorobenzene, 1180 ml of sulpholane, 10.7 g of 3-nitrodimethyl-benzamide and 640 g of dry KF were initially charged in an autoclave, then 48 g of CNC catalyst were added and the autoclave was sealed. The mixture was heated to 220°C for 48 h. During the reaction, a maximum total pressure of 8 bar arose. Subsequently, the mixture was cooled to 20°C. The product was distilled off initially at standard pressure, later under reduced pressure. 310 g of a colourless liquid having a proportion of 87% by weight of 1,3,5-trifiuorobenzene (74% of theory) and 8.8% by weight of difluorochlorobenzene (6.7% by weight of theory) were obtained. 1,3,5-Trifluorobenzene and difluorochlorobenzene can be separated distillatively in a known manner.





WE CLAIM:
1. Process for preparing 4,5,6-trifluoropyridimine, 1,3,5-trifluorobenezene or 3,4,5-
trifluorobenzotrifluoride which are useful in preparing biologically active substances for
pharmaceutical and agrochemical applications,
by reacting 4,5,6-trichloropyridimine, 1,3,5-trichlorobenezene or 3,4,5-trichlorobenzotrifluoride,
with a fluoride in the presence of at least one compound of the structure (III-1) or (III-2),.
(Formula Removed)
wherein the reaction is optionally carried out at least a temperature of 40 to 260°C and
characterized in that
the reaction in effected in one stage.
2. Process as claimed in claim 1, wherein based on 1 mol of halogen which is bonded to the
ring of the compound selected from the group 4,5,6- trichloropyridimine, 1,3,5-
trichlorobenezene or 3,4,5-trichlorobenzotrifluoride and is to be exchanged for fluorine,
0.001 to 0.5 mol of one or more compounds of the formula (III-l) or (III-2) and 0.8 to 2
equivalents of one or more fluorides are used.

3. Process as claimed in claim 1, wherein the said process is carried out in the presence of dipolar aprotic and/or nonplar aprotic solvents of the kind such as herein described.

Process as claimed in claim 1, wherein the fluoride used is at least one alkali metal, alkaline earth metal or ammonium fluoride of the kind such as herein described.


Documents:

1746-DEL-2005-Abstract-(09-01-2009).pdf

1746-del-2005-abstract.pdf

1746-DEL-2005-Claims-(09-01-2009).pdf

1746-DEL-2005-Claims-(11-06-2009).pdf

1746-del-2005-claims.pdf

1746-DEL-2005-Correspondence-Others-(09-01-2009).pdf

1746-DEL-2005-Correspondence-Others-(11-06-2009).pdf

1746-del-2005-correspondence-others.pdf

1746-DEL-2005-Description (Complete)-(09-01-2009).pdf

1746-del-2005-description (complete).pdf

1746-DEL-2005-Form-1-(09-01-2009).pdf

1746-del-2005-form-1.pdf

1746-del-2005-form-18.pdf

1746-DEL-2005-Form-2-(09-01-2009).pdf

1746-del-2005-form-2.pdf

1746-DEL-2005-Form-3-(09-01-2009).pdf

1746-del-2005-form-3.pdf

1746-del-2005-form-5.pdf

1746-DEL-2005-GPA-(09-01-2009).pdf

1746-del-2005-gpa.pdf

1746-DEL-2005-Petition-137-(09-01-2009).pdf

1746-DEL-2005-Petition-138-(09-01-2009).pdf

abstract.jpg


Patent Number 235427
Indian Patent Application Number 1746/DEL/2005
PG Journal Number 31/2009
Publication Date 31-Jul-2009
Grant Date 02-Jul-2009
Date of Filing 05-Jul-2005
Name of Patentee LANXESS DEUTSCHLAND GMBH
Applicant Address D-51369 LEVERKUSEN, GERMANY.
Inventors:
# Inventor's Name Inventor's Address
1 AXEL PLESCHKE IM THURNER FELD 41, 51069 KOLN, GERMANY.
2 ALBRECHT MARHOLD CARL-DUISBERG-STR. 329. 51373 LEVERKUSEN, GERMANY.
PCT International Classification Number C07D 213/61
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 1020040335257 2004-07-08 Germany