Title of Invention

"FUNGICIDAL COMPOSITION COMPRISING A PYRIDYLMETHYLBENZAMIDE DERIVATIVE AND A SULFAMIDE DERIVATIVE"

Abstract A composition comprising: a) a pyridylmethylbenzamide derivative of general formula (I) in which: R1 may be a hydrogen atom, an optionally substituted alkyl group or an optionally substituted acyl group; R2 may be a hydrogen atom or an optionally substituted alkyl group; R3 and R4 may be chosen independently from each other as being a halogen atom, a hydroxyl group, a cyano group, a nitro group, -SFs, a trialkylsilyl group, an optionally substituted amino group, an acyl group, or a group E, OE or SE, in which E may be an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl or a heterocyclyl group each of which may optionally be substituted; p represents 0, 1, 2, 3 or 4; q represents 0, 1, 2, 3 or 4; and its agriculturally acceptable optical and/or geometric isomers, tautomers and addition salts with an acid or a base; and b) N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide; in a (a)/(b) weight ratio of from 0.01 to 10.
Full Text The present invention relates to novel fungicidal compositions comprising a pyridylmethylbenzamide derivative and a sulfamide derivative. The present invention also relates to a method of combating phytopathogenic fungi by applying at a locus infested or liable to be infested such a composition.
European patent application EP-A-1056723 generically discloses the possibility of combining pyridylmethybenzamide derivatives with known fungicidal products to develop a fungicidal activity.
International patent application WO 02/069713 discloses fungicidal mixtures comprising a pyridylmethylbenzamide derivative and phosphorous acid or one of its derivatives.
Some of the above mentioned mixtures have shown a synergistic effect. Nevertheless, it is'always of high-interest in agriculture to use novel pesticidal mixtures showing a synergistic effect in order to avoid or to control the development of resistant strains to the active ingredients or to the mixtures of known active ingredients used by the farmer while minimising the doses of chemical products spread in the environment and reducing the cost of the treatment.
We have now found some novel fungicidal compositions which possess the above mentioned characteristics.
Accordingly, the present invention relates to a composition comprising : a) a pyridylmethylbenzamide derivative of general formula (I)
(Formula Removed)

in which:
- R1 may be a hydrogen atom, an optionally substituted alkyl group or an optionally substituted acyl group;
-R2 may be a hydrogen atom or an optionally substituted alkyl group;

in which:
- R,1 may be a hydrogen atom, an optionally substituted alkyl group or an
optionally substituted acyl group;
- R2 may be a hydrogen atom or an optionally substituted alkyl group;
- R3 and R4 may be chosen independently from each other as being a halogen
atom, a hydroxyl group, a cyano group, a nitro group,.-SF5, a trialkylsilyl group, an
optionally substituted amino group, an acyl group, or a group E, OE or SE, in which
E may be an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl or a heterocyclyl
group each of which may optionally be substituted;
- p represents 0,1, 2, 3 or 4;
- q represents 0, 1, 2, 3 or 4;
and its agriculturally acceptable optical and/or geometric isomers, tautomers and
addition salts with an acid or a base;
and
N-dichlorofluoromethylthio-N'jN'-dimethyl-N-p-tolylsulfamide;
in a (a) / (b) weight ratio of from 0.01 to 10.
N-dichlorofluoromethylthio-N'jN'-dimethyl-N-p-tolylsulfamide is a sulfamide
derivative fungicide also known as tolylfluanid.
In the context of the present invention :
- the term halogen means bromine, chlorine, iodine or fluorine;
- the term alkyl means a linear or branched saturated hydrocarbon group containing
from 1 to 6 carbon atoms;
- the term alkenyl means a linear or branched hydrocarbon group containing from 2
to 6 carbon atoms and an unsaturation in the¥orm of double bond;
- the term alkynyl means a linear or branched hydrocarbon group containing from 2
to 6 carbon atoms and an unsaturation hi the form of a triple bond;
- the term alkoxy means a linear or branched alkyloxy group containing from to 1 to
6 carbon atoms;
- the term acyl means a formyl group or linear or branched alkoxycarbonyl group
containing from 2 to 6 carbon atoms;
- the term cycloalkyl means a saturated cyclic hydrocarbon group containing from 3
to 8 carbon atoms;
- the term aryl means a phenyl or naphthyl group;
- the term heterocyclyl means saturated, partially saturated, unsaturated or aromatic
cyclic group containing from 3 to 8 atoms, which may be a carbon atom, a nitrogen
atom, a sulphur atom or an oxygen atom. Examples of such hetercoyclyl may be
pyridyl, pyridinyl, quinolyl, furyl, thienyl, pyrrolyl, oxazolinyl;
- the term "optionally substituted " means that the group thus termed may be
substituted with one or more groups which may be halogen, alkyl, alkoxy, hydroxyl,
nitro, amin, cyano or acyl.
The composition according to the present invention provides a synergistic
effect. This synergistic effect allows a reduction of the chemical substances spread
into the environment and a reduction of the cost of the fungal treatment.
In the context of the present invention, the term "synergistic effect" is defined
by Colby according to the article entitled "Calculation of the synergistic and
antagonistic responses of herbicide combinations" Weeds, (1967), 15, pages 20-22.
The latter article mentions the formula:
100
in which E represents the expected percentage of inhibition of the disease for the
combination of the two fungicides at defined doses (for example equal to x and y
respectively), x is the percentage of inhibition observed for the disease by the
compound (I) at a defined dose (equal to x), y is the percentage of inhibition
observed for the disease by the compound (II) at a defined dose (equal to y). When
the percentage of inhibition observed for the combination is greater than E, there is a
synergistic effect.
In the context of the present invention, the term "synergistic effect" also
means the effect defined by application of the Tammes method, "Isoboles, a graphic
representation of synergism in pesticides", Netherlands Journal of Plant Pathology,
70(1964), pages 73-80.
The composition according to the present invention comprises a
pyridylmethylbenzamide derivative of general formula (I).
Preferably, the present invention relates to a composition comprising a
pyridylmethylbenzamide derivative of general formula (I) in which the different
characteristics may be chosen alone or in combination as being :
- as regards R1 and R2, R1 and R2 may be chosen independently from each
other as being a hydrogen atom or an optionally substituted alkyl group. More
preferably, R1 and R2 may be chosen independently from each other as being a
hydrogen atom, a methyl group or an ethyl group. Even more preferably, R1 and
may be both hydrogen atoms.
- as regards R3 and R4, R3 and R4 may be chosen independently from each
other as being a halogen atom, a hydroxyl group,.a nitro group, an optionally
substituted amino group, an acyl group, or a group E, OE or SE, in which E may be a
alkyl, a cycloalkyl, a phenyl or a heterocyclyl group, each of which may optionally
be subtituted. More preferably, R3 and R4 may be chosen independently from each
other as being a halogen atom, a nitro group or a halogenoalkyl group. Even more
preferably R3 and R4 may be chosen independently from each other as being a
chlorine atom, a nitro group or a trifluoromethyl group.
- as regards p, p may be 1 or 2. More preferably, p may be 2.
- as regards q, q may be 1 or 2. More preferably, q may be 2;
and its agriculturally acceptable possible tautomers and addition salts with an acid or
a base.
More preferably, the pyridylmethylbenzamide derivative of general formula
(I) present in the composition of the present invention is :
- a compound (la) which is 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-
pyridinyl]methyl}benzamide; or
a compound (Ib) which is N-{[3-chloro-5-(trifluoromethyl)-2-
pyridinyl]methyl}-2-fluoro-6-nitrobenzamide; or
a compound (Ic) which is N-{[3-chloro-5-(trifluoromethyl)-2-
pyridinyl]methyl}-2-methyl-6-nitrobenzamide;
and its agriculturally acceptable possible tautomers and addition salts with an
acid or a base.
The composition according to the present invention comprises at least a
pyridylmethylbenzamide derivative of general formula (I) (a) and tolylfluanid (b) in
an (a) / (b) weight ratio of from 0.01 to 10; preferably of from 0.05 to 0.5; even more
preferably, of from 0.1 to 0.2.
The composition of the present invention may further comprise a third
fungicide active ingredient (c).
The third fungicidal active ingredient may preferably be selected from
phosphorous acid derivative, phosphorous acid itself, or alkali metal, alkaline-earth
metal or metallic salts thereof. More preferably, the additional fungicidal compound
may be chosen as being ethyl hydrogen phosphonate.
Ethyl hydrogen phosphonate is a fungicidal compound also known as
Fosetyl-AL
Where the third active ingredient (c) as defined above is present in the
composition, this compound may be present in an amount of (a) : (b) : (c) weight
ratio of from 0.01 : 1 : 0.1 to 10 : 1 : 10; the ratios of compound (a) and compound
(c) varying independently from each other. Preferably, the (a): (b) : (c) weight ratio
may be of from 0.05 : 1 : 0.5 to 0.5 : 1 : 5; more preferably of from 0.1 : 1 : 1 to 0.2 :
1 :4.
The composition according to the present invention may further comprise an
other additional component such as an agriculturally acceptable support, carrier or
filler.
In the present specification, the term "support" denotes a natural or synthetic,
organic or inorganic material with which the active material is combined to make it
easier to apply, notably to the parts of the plant. This support is thus generally inert
and should be agriculturally acceptable. The support may be a solid or a liquid.
Examples of suitable supports include clays, natural or synthetic silicates, silica,
resins, waxes, solid fertilisers, water, alcohols, in particular butanol, organic solvents,
mineral and plant oils and derivatives thereof. Mixtures of such supports may also be
used.
The composition may also comprise other additional components. In
particular, the composition may further comprise a surfactant. The surfactant can be
an emulsifier, a dispersing agent or a wetting agent of ionic or non-ionic type or a
mixture of such surfactants. Mention may be made, for example, of polyacrylic acid
salts, lignosulphonic acid salts, phenolsulphonic or naphthalenesulphonic acid salts,
polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty
amines, substituted phenols (in particular alkylphenols or arylphenols), salts of
sulphosuccinic acid esters, taurine derivatives (in particular alkyl taurates),
phosphoric esters of polyoxyethylated alcohols or phenols, fatty acid esters of
polyols, and derivatives of the above compounds containing sulphate, sulphonate and
phosphate functions. The presence of at least one surfactant is generally essential
when the active material and/or the inert support are water-insoluble and when the
vector agent for the application is water. Preferably, surfactant content may be
comprised between 5% and 40% by weight of the composition.
Additional components may also be included, e.g. protective colloids,
adhesives, thickeners, thixotropic agents, penetration agents, stabilisers, sequestering
agents. More generally, the active materials can be combined with any solid or liquid
additive, which complies with the usual formulation techniques.
In general, the composition according to the invention may contain from 0.05
to 99% (by weight) of active material, preferably 10 to 70% by weight.
Compositions according to the present invention can be used in various forms
such as aerosol dispenser, capsule suspension, cold fogging concentrate, dustable
powder, emulsifiable concentrate, emulsion oil in water, emulsion water in oil,
encapsulated granule, fine granule, flowable concentrate for seed treatment, gas
(under pressure), gas generating product, granule, hot fogging concentrate,
macrogranule, microgranule, oil dispersible powder, oil miscible flowable
concentrate, oil miscible liquid, paste, plant rodlet, powder for dry seed treatment,
seed coated with a pesticide, soluble concentrate, soluble powder, solution for seed
treatment, suspension concentrate (flowable concentrate), ultra low volume (ulv)
liquid, ultra low volume (ulv) suspension, water dispersible granules or tablets, water
dispersible powder for slurry treatment, water soluble granules or tablets, water
soluble powder for seed treatment and wettable powder.
These compositions include not only compositions which are ready to be
applied to the plant or seed to be treated by means of a suitable device, such as a
spraying or dusting device, but also concentrated commercial compositions which
must be diluted before they are applied to the crop.
The fungicidal compositions of the present invention can be used to curatively
or preventively control the phytopathogenic fungi of crops. Thus, according to a further
aspect of the present invention, there is provided a method for preventively or
curatively controlling phytopathogenic fungi of crops characterised in that a fungicidal
composition as hereinbefore defined is applied to the seed, the plant and/or to the fruit
of the plant or to the soil in which the plant is growing or in which it is desired to grow.
The composition as used against phytopathogenic fungi of crops comprises an
effective and non-phytotoxic amount of an active material of general formula (I).
The expression "effective and non-phytotoxic amount" means an amount of
composition according to the invention which is sufficient to control or destroy the
fungi present or liable to appear on the crops, and which does not entail any appreciable
symptom of phytotoxicity for the said crops. Such an amount can vary within a wide
range depending on the fungus to be combated, the type of crop, the climatic conditions
and the compounds included in the fungicidal composition according to the invention.
This amount can be determined by systematic field trials, which are within the
capabilities of a person skilled in the art.
The method of treatment according to the present invention is useful to treat
propagation material such as tubers or rhizomes, but also seeds, seedlings or
seedlings pricking out and plants or plants pricking out. This method of treatment
can also be useful to treat roots. The method of treatment according to the present
invention can also be useful to treat the overground parts of the plant such as trunks,
stems or stalks, leaves, flowers and fruits of the concerned plant.
Among the plants that can be protected by the method according to the
invention, mention may be made of cotton; flax; vine; fruit or vegetables crops such
as Rosaceae sp: (for instance pip fruits such as apples and pears, but also stone fruits
such as apricots, almonds and peaches), Ribesioidae sp., Juglandaceae sp.,
Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp.,
Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and
plantins), Rubiaceae sp., Theaceae sp., Sterculiceae sp., Riitaceae sp. (for instance
lemons, oranges and grapefruits); leguminous crops such as Solanaceae sp. (for
instance tomatoes), Liliaceae sp., Asteraceae sp. (for instance lettuces), Umbelliferae
sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp., Papilionaceae sp. (for
instance peas), Rosaceae sp. (for instance strawberries); big crops such as Graminae
\ -V
sp. (for instance maize, lawn or cereals such as wheat, rice, barley and triticale),
Asteraceae sp. (for instance sunflower), Cruciferae sp. (for instance colza),
Papilionaceae sp. (for instance soja), Solanaceae sp. (for instance potatoes),
Chenopodiaceae sp. (for instance beetroots); horticultural and forest crops; as well as
genetically modified homologues of these crops.
Among the plants and the possible diseases of these plants protected by the
method according to the present invention, mention may be made of:
- wheat, as regards controlling the following seed diseases: fusaria
(Microdochium nivale and Fusarium rosewri), stinking smut (Tittetia caries, Tilletia
controversa or Tilletia indica), septoria disease (Septoria nodorwn) and loose smut;
- wheat, as regards controlling the following diseases of the aerial parts of the
plant: cereal eyespot (Tapesia yallundae, Tapesia acuiformis), take-all
(Gaeumannomyces graminis), foot blight (F. culmorum, F. graminearum), black speck
(Rhizoctonia cerealis), powdery mildew (Erysiphe graminis forma specie tritici), rusts
(Puccinia striiformis and Puccinia reconditd) and septoria diseases (Septoria tritici and
Septoria nodorum);
- wheat and barley, as regards controlling bacterial and viral diseases, for
example barley yellow mosaic;
- barley, as regards controlling the following seed diseases: net blotch
(Pyrenophora graminea, Pyrenophora teres and Cochliobolus sativus), loose smut
(Ustilago nuda) and fusaria (Microdochium nivale and Fusarium roseum);
- barley, as regards controlling the following diseases of the aerial parts of the
plant: cereal eyespot (Tapesia yallundae), net blotch (Pyrenophora teres and
Cochliobolus sativus), powdery mildew (Erysiphe graminis forma specie hordei),
dwarf leaf rust (Puccinia hordei) and leaf blotch (Rhynchosporium secalis);
- potato, as regards controlling tuber diseases (in particular Hehninthosporium
solani, Phoma -tuberosa, Rhizoctonia solani, Fusarium solani), mildew (Phytopthora
infestans) and certain viruses (virus Y);
- potato, as regards controlling the following foliage diseases: early blight
(Alternaria solani), mildew (Phytophthora infestans)',
- cotton, as regards controlling the following diseases of young plants grown
from seeds: damping-off and collar rot (Rhizoctonia solani, Fusarium oxysporuni) and
black root rot (Thielaviopsis basicola);
- protein yielding crops, for example peas, as regards controlling the
following seed diseases: anthracnose (Ascochyta pisi, Mycosphaerella pinodes),
fusaria (Fusarium oxysporum), grey mould (Botrytis -cinerea) and mildew
(Peronospora pisi);
- oil-bearing crops, for example rape, as regards controlling the following
seed diseases: Phoma lingam, Alternaria brassicae and Sclerotinia sclerotiorum;
- corn, as regards controlling seed diseases: (Rhizopus sp., Penicillium sp.,
Trichoderma sp., Aspergillus sp., and Gibberellajujikuroi);
- flax, as regards controlling the seed disease: Alternaria linicola;
- forest trees, as regards controlling damping-off (Fusanum oxysporum,
Rhizoctonia solani);
- rice, as regards controlling the following diseases of the aerial parts: blast
disease (Magnaporthe grisea), bordered sheath spot (Rhizoctonia solani);
- leguminous crops, as regards controlling the following diseases of seeds or
of young plants grown from seeds: damping-off and collar rot (Fusarium oxysporum,
Fusanum roseum, Rhizoctonia solani, Pythium sp.);
- leguminous crops, as regards controlling the following diseases of the aerial
parts: grey mould (Botrytis sp.), powdery mildews (in particular Erysiphe
cichoracearum, Sphaerotheca fuliginea and Leveillula taurica), fusaria (Fusarium
oxysporum, Fusarium roseum), leaf spot (Cladosporium sp.), alternaria leaf spot
(Alternaria sp.), anthracnose (Colletotrichum sp.), septoria leaf spot (Septoria sp.),
black speck (Rhizoctonia solani), mildews (for example Bremia lactucae,
Peronospora sp., Pseudoperonosporasp., Phytophthora sp.);
- fruit trees, as regards diseases of the aerial parts: monilia disease (Manilla
fructigenae, M. laxa), scab (Venturia inaequalis), powdery mildew (Podosphaera
leucotricha);
- vine, as regards diseases of the foliage: in particular grey mould (Botrytis
cinerea), powdery mildew (Uncinula necator), black rot (Guignardia biwelli) and
mildew (Plasmopara viticola);
- beetroot, as regards the following diseases of the aerial parts: cercospora
blight (Cercospora beticola), powdery mildew (Erysiphe beticola), leaf spot
(Ramularia beticola).
Preferably, the plant that can be protected by the method according to the
present invention is vine.
The fungicidal composition according to the present invention may also be
used against fungal diseases liable to grow*on or inside timber. The term "timber"
means all types of species of wood, and all types of working of this wood intended
for construction, for example solid wood, high-density wood, laminated wood, and
plywood. The method for treating timber according to the invention mainly consists
in contacting one or more compounds of the present invention, or a composition
according to the invention; this includes for example direct application, spraying,
dipping, injection or any other suitable means.
The dose of active material usually applied in the treatment according to the
present • invention is generally and advantageously between 10 and 2000 g/ha,
preferably between 50 and 1500 g/ha for applications in foliar treatment. The dose of
active substance applied is generally and advantageously between 2 and 200 g per
100 kg of seed, preferably between 3 and 150 g per 100 kg of seed in the case of seed
treatment. It is clearly understood that the doses indicated above are given as
illustrative examples of the invention. A person skilled in the art will know how to
adapt the application doses according to the nature of the crop to be treated.
The fungicidal composition according to the present invention may also be
used in the treatment of genetically modified organisms with the compounds
according to the invention or the agrochemical compositions according to the
invention. Genetically modified plants are plants into whose genome a heterologous
gene encoding a protein of interest has been stably integrated. The expression
"heterologous gene encoding a protein of interest" essentially means genes which
give the transformed plant new agronomic properties, or genes for improving the
agronomic quality of the transformed plant.
The compositions according to the present invention may also be used fore
the preparation of composition useful to curatively or preventively treat human and
animal fungal -diseases such as, for example, mycoses, dermatoses, trichophyton
diseases and candidiases or diseases caused by Aspefgillus spp., for example
Aspergillusfumigatus.
The present invention will now be illustrated by way of the following
examples.
Example : treatment of vine with a composition according to the invention
This example demonstrates a syriergy for a mixture of 2,6-dichloro-N-{[3-
chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}benzaniide (compound la) and
tolylfluanid on Vine downy mildew (Plasmopara Viticold) in 72h preventive
application on tomato.
Vine plants (Cabernet -Sauvignon variety) were grown in a sandy soil in
plastic pots with a single plant per pot. At the age of 2 months (6 to 7 leaves
developed), these plants were sprayed with the two fungicides either alone or in a
mixture. Fungicide compounds applied in mixtures were also applied singly at the
same doses as those used in the combinations. The fungicide compounds, either
alone or in mixtures, were applied at a volume rate of 2501 water per ha.
Three weight ratios of the mixture of compound la / tolylfluanid have been
studied : 1/5,1/6.67 and 1/10.
Starting with compound la in the form of suspension concentrate (SC) at
480g/l and tolylfluanid in the form of Water Dispersible Granules (WG) 500g/kg
(Euparene), plant protection mixtures for application corresponding to a volume of
2501 of liquid per ha are prepared.
The dose range of compound la corresponds to 1.56 mg/1, 12.5 mg/1,25 mg/1,
50 mg/1 and 75 mg/1.
Three days after treatment, each plant was inoculated by spraying an aqueous
suspension of sporangia ofPlasmopara viticola obtained from contaminated leaves.
The concentration of sporangia was about 100,000 units per ml.
After contamination the plants were incubated for two days at 18°C in a
saturated atmosphere and then for 5 days at about 20°C with 90-100% relative
humidity. - ,
Seven days after contamination, symptoms were evaluated in terms of the
extent of the lower surface of the leaves infected, in comparison with untreated but
contaminated plants.
The efficacy of the treatment was calculated using the Abbott formula:
Efficacy = (Untreated - Treated / Untreated ) x 100
The concentrations of the fungicide compounds alone or in a mixture giving
50%, 70% and 90% efficacy for each component were determined based on the
sigmoid curve dose / response model with their confidence intervals.
The analyses of the results were carried out using the TAMMES model
(Isoboles, a graphic representation of synergism in pesticides, Neth.J. Plant Path. 70
(1964): 73-80) or Colby model.
The results obtained are presented in the form of point values, corresponding
to 50%, 70% or 90% control of the pathogen and placed in a Tamnies isobole
diagram which comprises on the x-axis the doses of Compound la expressed in mg/1
and on the y-axis the doses of tolylfluanid also in mg/1.
The calculated results corresponding to ED50, ED70 and ED90 (effective
doses providing 50%, 70% and 90% of disease control) for the various ratios of the
mixtures that have been evaluated are presented in the following Table 1, 2 and 3.
(Table Removed)
These results have been calculated on the basis of 3 repeats per factor
according to the Tammes method taking into account the product efficacy for a range
of ratios and for method for 50%, 70% and 90% of disease control on tomato.
This preventive test on tomato late blight shows the synergism of the
fungicide compositions containing compounds A and B at ratios equal to 1/5 ,1/6.67
and 1/10. It has been demonstrated that less amount of both compounds are
necessary to control 50%, 70% and 90% of the disease compared to the theoretical
doses of each compounds expected in the mixture with just additional effect.
A synergy of the above mixture is also demonstrated when data are analysed
according to Colby method. Following Table 4 presents the results obtained based on
using the Colby method for evaluating the synergy of the mixture of compound la
with tolylfluanid according to the invention. Practical efficacy is superior to
theoretical efficacy showing the synergism of the fungicide compositions containing
compounds la and tolylfluanid at ratios equal to 1/5 , 1/6.67 and 1/10.
(Table Removed)
Table 3 : Synergism according to Colby method between compound la and
tolylfluanid on vine downy mildew





WE CLAIM:
1. A composition comprising:
a) a pyridylmethylbenzamide derivative of general formula (I)
(Formula Removed)

in which:
R1 may be a hydrogen atom, an optionally substituted alkyl group or an optionally substituted acyl group;
R2 may be a hydrogen atom or an optionally substituted alkyl group;
R3 and R4 may be chosen independently from each other as being a halogen atom, a hydroxyl group, a cyano group, a nitro group, -SF5, a trialkylsilyl group, an optionally substituted amino group, an acyl group, or a group E, OE or SE, in which E may be an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl or a heterocyclyl group each of which may optionally be substituted;
p represents 0, 1, 2, 3 or 4;
q represents 0, 1, 2, 3 or 4; and its agriculturally acceptable optical and/or geometric isomers, tautomers and addition salts with an acid or a base; and b) N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide; in a (a)/(b) weight ratio of from 0.01 to 10.
2. A composition as claimed in claim 1, wherein R1 and R2 are chosen independently from each other as being a hydrogen atom or an optionally substituted alkyl group.

3. A composition as claimed in claim 1, wherein R1 and R2 are both hydrogen atoms.
4. A composition as claimed in any one of the claims 1 to 3, wherein R3 and R4 are chosen independently from each other as being a halogen atom, a hydroxyl group, a nitro group, an optionally substituted amino group, an acyl group, or a group E, OE or SE, in which E may be a alkyl, a cycloalkyl, a phenyl or a heterocyclyl group, each of which may optionally be substituted.
5. A composition as claimed in claim 4, wherein R3 and R4 are chosen independently from each other as being a halogen atom, a nitro group or a halogenoalkyl group.
6. A composition as claimed in claim 5, wherein the halogen atom is a chlorine atom and the halogenoalkyl group is a trifluoromethyl group.
7. A composition as claimed in any one of the claims 1 to 6, wherein p and q are chosen independently from each other as being is 1 or 2.
8. A composition as claimed in claim 7, wherein p is 2.
9. A composition as claimed in claim 7 or 8, wherein q is 2.
10. A composition as claimed in any one of the claims 1 to 9, wherein the compound of general formula (I) is chosen as being
a compound (la) which is 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}benzamide; or
a compound (lb) which is N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-fluoro-6-nitrobenzamide; or
a compound (Ic) which is N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl] methyl}-2 -methyl-6-nitrobenzamide.

11. A composition as claimed in any one of the claims 1 to 10, wherein the (ay(b) weight ratio is of from 0.05 to 0.5.
12. A composition as claimed in claim 11, wherein the (a)/(b) weight ratio is of from 0.1 to 0.2.
13. A composition as claimed in any one of the claims 1 to 12, further comprising a fungicidal compound (c).
14. A composition as claimed in claim 13, wherein the optional fungicidal compound is selected from phosphorous acid derivative, phosphorous acid itself, or alkali metal, alkaline-earth metal or metallic salts thereof.
15. A composition as claimed in claim 14, wherein the optional fungicidal compound is ethyl hydrogen phosphonate.
16. A composition as claimed in any one of the claims 13 to 15, wherein compound (c) is present in an amount of (a): (b) : (c) weight ratio of from 0.01: 1 : 0.1 to 10:1 : 10; the ratios of compound (a) and compound (c) varying independently from each other.
17. A composition as claimed in any one of the claims 1 to 16, wherein it optionally comprises an agriculturally acceptable support, carrier, filler and/or. surfactant.

Documents:

493-DELNP-2006-Abstract-(20-05-2009).pdf

493-delnp-2006-abstract.pdf

493-DELNP-2006-Claims-(20-05-2009).pdf

493-delnp-2006-claims.pdf

493-DELNP-2006-Correspondence-Others-(20-05-2009).pdf

493-delnp-2006-correspondence-others-1.pdf

493-delnp-2006-correspondence-others.pdf

493-DELNP-2006-Description (Complete)-(20-05-2009).pdf

493-delnp-2006-description (complete).pdf

493-delnp-2006-form-1.pdf

493-delnp-2006-form-18.pdf

493-delnp-2006-form-2.pdf

493-delnp-2006-form-3.pdf

493-delnp-2006-form-5.pdf

493-DELNP-2006-GPA-(20-05-2009).pdf

493-delnp-2006-gpa.pdf

493-delnp-2006-pct-101.pdf

493-delnp-2006-pct-210.pdf


Patent Number 234484
Indian Patent Application Number 493/DELNP/2006
PG Journal Number 25/2009
Publication Date 19-Jun-2009
Grant Date 01-Jun-2009
Date of Filing 30-Jan-2006
Name of Patentee BAYER CROPSCIENCE S.A.
Applicant Address 16, RUE JEAN-MARIE LECLAIR, F-69009 LYON,FRANCE,
Inventors:
# Inventor's Name Inventor's Address
1 THOMAS WEGMANN IM BRUCHFELD 27,40764 LANGENFELD,GERMANY.
2 RICHARD MERCER 14,RUE DU DOMAINE,F-69130 ECULLY FRANCE.
3 MARIE-PASCALE LATORSE LIEU DIT "LA POSTE"-RN7, F-69490 ,FRANCE.
PCT International Classification Number A01N 43/00
PCT International Application Number PCT/EP2004/013117
PCT International Filing date 2004-10-28
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 03356170.5 2003-10-31 EPO