Title of Invention	"SUBSTITUTED DIHYDROQUINAZOLINE COMPOUNDS"
Abstract	Substituted dihydroquinazoline compounds of the formula I and to processes for their preparation and also their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

Full Text

The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses. The synthesis of dihydroquinazolines is described in Saito T., et al. Tetrahedron Lett., 1996, 37, 209-212 and in Wang F., et al. Tetrahedron Lett., 1997, 38, 8651-8654. Although agents with antiviral activity and a different structure are available on the market, it is always possible for resistance to develop. Novel agents for an effective therapy are therefore desirable. One object of the present invention is therefore to provide novel compounds having the same or improved antiviral effect for the treatment of viral infective diseases in humans and animals. It has been found, surprisingly, that the substituted dihydroquinazolines described in the present invention have antiviral effect. The present invention provides compounds of the formula (Formula Removed) in which Ar represents aryl which may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of alkyl, alkoxy, formyl, carboxyl, alkylcarbonyl, alkoxycarbonyl, rrifluoromethyl, halogen, cyano, hydroxyl, amino, alkylamino, aminocarbonyl and nitro, where alkyl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of halogen, amino, alkylamino, hydroxyl and aryl, where alkyl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of halogen, amino, alkylamino, hydroxyl and aryl, or two of the substituents on the aryl radical together with the carbon atoms to. which they are attached form a 1,3-dioxolane, a cyclopentane ring or a cyclohexane ring, and any third substituent present is selected independently from the group mentioned, R1 represents hydrogen, amino, alkyl, alkoxy, alkylamino, alkylthio, cyano, halogen, nitro or trifluoromethyl, R2 represents hydrogen, alkyl, alkoxy, alkylthio, cyano, halogen, nitro or trifluoromethyl, R3 represents amino, alkyl, alkoxy, alkylamino, alkylthio, cyano, halogen, nitro, trifluoromethyl, alkylsulphonyl or alkylaminosulphonyl or one of the radicals R1, R2 and R3 represents hydrogen, alkyl, alkoxy, cyano, halogen, nitro or trifluoromethyl and the other two together with the carbon atoms to which they are attached form a 1,3-dioxolane, a cyclopentane ring or a cyclohexane ring, R4 represents hydrogen or alkyl, R5 represents hydrogen or alkyl or the radicals R4 and R5 are attached to carbon atoms directly opposing each other in the piperazine ring and form a methylene bridge which is optionally substituted by 1 or 2 methyl groups, R6 represents alkyl, alkoxy, alkylthio, formyl, carboxyl, aminocarbonyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hydroxyl or nitro, R7 represents hydrogen, alkyl, alkoxy, alkylthio, formyl, carboxyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hydroxyl or nitro and R8 represents hydrogen, alkyl, alkoxy, alkylthio, formyl, carboxyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hydroxyl or nitro, and their salts, their solvates and the solvates of their salts. Compounds according to the invention are the compounds of the formula (I) and their salts, solvates and solvates of the salts, compounds mentioned below as embodiment(s) and their salts, solvates and solvates of the salts, unless the compounds below, embraced by formula (I), are already salts, solvates and solvates of the salts. The compounds according to the invention may, depending on their structure, exist in stereoisomeric. forms (enantiomers, diastereomers). The invention therefore relates to the enantiomers or diastereomers and respective mixtures thereof. The stereoisomerically pure constituents can be isolated in a known manner from such mixtures of enantiomers and/or diastereomers. If the compounds according to the invention may exist in tautomeric forms, the present invention embraces all such tautomeric forms. Salts which are preferred for the purposes of the present invention are physiologically acceptable salts of the compounds according to the invention. However, the invention also embraces salts which are per se not suitable for pharmaceutical applications but can be used, for example, for isolating or purifying the compounds according to the invention. Physiologically acceptable salts of the compounds according to the invention include acid addition salts of mineral acids, carboxylic acids and sulphonic acids, for example salts of hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, methanesulphonic acid, ethanesulphonic acid, toluenesulphonic acid, benzenesulphonic acid, naphthalenedisulphonic acid, acetic acid, trifluoroacetic acid, propionic acid, lactic acid, tartaric acid, malic acid, citric acid, fumaric acid, maleic acid and benzoic acid. Physiologically acceptable salts of the compounds according to the invention also include salts of customary bases, such as, by way of example and preferably, alkali metal salts (for example sodium and potassium salts), alkaline earth metal salts (for example* calcium and magnesium salts) and ammonium salts derived from ammonia or organic amines having 1 to 16 carbon atoms, such as, by way of example and preferably, ethylamine, diethylamine, triethylamine, ethyldiisopropylamine, monoethanolamine, diethanolamine, triethanolamine, dicyclohexylamine, dimethylaminoethanol, procaine, dibenzylamine, N-methylmorpholine, arginine, lysine, ethylenediamine and N-methylpiperidine. Solvates refer for the purposes of the invention to those forms of the compounds according to the invention which form a complex in the solid or liquid state by coordination with solvent molecules. Hydrates are a special form of solvates in which the coordination takes place with water. or the purposes of the present invention, unless specified otherwise, the substituents have the following meanings: Alkvl perse and "alk" and "alkvl" in alkoxv. alkvlamino, alkvlcarbonvK alkylsulphonvl. atkylamiaosulphonyl and alkoxycarbonvl are a straight-chain or branched alkyl radical having generally 1 to 6, preferably 1 to 4, particularly preferably 1 to 3, carbon atoms, by way of example and preferably methyl, ethyl, n-propyl, isopropyl, tert-butyl, n-pentyl and n-hexyl. Alkoxv is, by way of example and preferably, methoxy, ethoxy, n-propoxy, isopropoxy, tert-butoxy, n-pentoxy and n-hexoxy. Alkylamino is an alkylamino radical having one or two alkyl substituents (chosen independently of one another), by way of example and preferably methylamino, ethylamino, n-propylamino, isopropylamino, tert-butylamino, n-pentylamino, n-hexylamino, N,N-dimethylamino, N.N-diethylamino, N-ethyl-N-methylamino, N-methyl-N-n-propylamino, N-isopropyl-N-n-propyl-amino, N-tert-butyl-N-memylamino, N-ethyl-N-n-pentylamino and N-n-hexyl-N-methylamino. C1-C3-alkylamino is, for example, a monoalkylaminb radical having 1 to 3 carbon atoms or a dialkylamino radical having in each case 1 to 3 carbon atoms per alkyl substituent. Alkvlsulphonvl is, by way of example and preferably, methylsulphonyl, ethylsulphonyl, n-propyl-sulphonyl, isopropylsulphonyl, tert-butylsulphonyl, n-pentylsulphonyl and n-hexylsulphonyl. Alkvlaminosulphonvl is an alkylaminosulphonyl radical having one or two alkyl substituents (chosen independently of one another), by way of example and preferably methylaminosulphonyl, ethylaminosulphonyl, n-propylaminosulphonyl, isopropylaminosulphonyl, tert-butylaminosulphonyl, n-pentylaminosulphonyl, n-hexyl-aminosulphonyl, N, N-dimethylaminosulphonyl, N,N-diett\y\-aminosulphonylj N-emyl-N-methylaminosulphonyl, N-methyl-N-n-propylaminosulphonyl, N-isopropyl-N-n-propyl-aminosulphonyl, N-tert-butyl-A'-methylaminosulphonyl, N-ethyl-N-n-pentyl-aminosulphonyl and N-n-hexyl-N-methylammosulphonyl. C1-C3-alkylaminosulphonyl is, for example, a monoalkylaminosulphonyl radical having 1 to 3 carbon atoms or a dialkylaminosulphonyl radical having in each case 1 to 3 carbon atoms per alkyl substituent. Alkvlcarbonyl is, by way of example and preferably, acetyl and propanoyl. Alkoxvcarbonvl is, by way of example and preferably, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, n-pentoxycarbonyl and n-hexoxy-carbonyl. Aryl is a mono- to tricyclic aromatic carbocyclic radical having generally 6 to 14 carbon atoms; by way of example and preferably phenyl, naphthyl and phenanthrenyl. Halogen is fluorine, chlorine, bromine and iodine, preferably fluorine and chlorine. A symbol * on a carbon atoms means that the compound, with respect to the configuration at this carbon atom, is present in enantiomerically pure form which, for the purposes of the present invention, is to be understood as meaning an enantiomeric excess of more than 90% (> 90% ee). Preference is given to those compounds of the formula (I) in which Ar represents phenyl which may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of C1-C6-alkyl, C1-C6-alkoxy, carboxyl, C1-C6-alkylcarbonyl, C1-C6-alkbxycarbonyl, trifluoromethyl, fluorine, chlorine, bromine, cyano, hydroxyl, amino, C1-C6-alkylamino and nitro, or two of the substituents on the phenyl radical together with the carbon atoms to which they are attached form a 1,3-dioxolane and any third substituent present is selected independently from the group mentioned, R1 represents hydrogen, C1-C3-alkyl, C1-C3-alkoxy, C1-C3-alkylthio, fluorine or chlorine, R2 represents hydrogen, C1-C3-alkyl, C1-C3-alkoxy, C1-C3-alkylthio, fluorine or chlorine, R3 represents C1-C4-alkyl, cyano, fluorine, chlorine, nitro, trifluoromethyl or C1-C3-alkylsulphonyl, one of the radicals R1, R2 and R3 represents hydrogen,C1-C3-alkyl, C1-C3-alkoxy, cyano, halogen, nitro or triflupromethyl and the other two together with the carbon atoms to which they are attached form a cyclopentane ring or a cyclohexane ring, R4 represents hydrogen or methyl, R5 represents hydrogen, R6 represents C1-C3-alkyl, C1-C3-alkoxy, carboxyl, aminocarbonyl, trifluoromethyl, fluorine, chlorine, cyano, hydroxyl or nitro, R7 represents hydrogen, C1-C3-alkyl, C1-C3-alkoxy, fluorine, chlorine, cyano or hydroxyl and represents hydrogen, C1-C3-alkyl, C1-C3-alkoxy, fluorine, chlorine, cyano or hydroxyl. Among these, particular preference is given to those compounds of the formula (T), in which AT represents phenyl which may be substituted by 1 or 2 substituents, where the substituents are selected independently of one another from the group consisting of methyl, methoxy, fluorine and chlorine, Rl represents hydrogen, methyl, methoxy, methylthio, fluorine or chlorine, R2 represents hydrogen, R3 represents methyl, isopropyl, tert-butyl, cyano, fluorine, chlorine, nitro or trifluoromethyl, R4 represents hydrogen, Rs represents hydrogen, R6 represents aminocarbonyl, fluorine, chlorine, cyano or hydroxyl, R7 represents hydrogen and R8 represents hydrogen, fluorine or chlorine. Among these, particular preference is also given to those compounds of the formula (I), in which Ar represents phenyl which may be substituted by 1 or 2 substituents, where the substituents are selected independently of one another from the group consisting of methyl, methoxy, fluorinejtnd chlorine, R1 represents hydrogen, methyl, methoxy, methylthio, fluorine or chlorine, R2 represents hydrogen, R3 represents methyl, tert-butyl, cyano, fluorine, chlorine, nitro or trifluoromethyl, R4 represents hydrogen, R5 represents hydrogen, R6 represents aminocarbonyl, fluorine, chlorine, cyano or hydroxyl, R7 represents hydrogen and R8 represents hydrogen, fluorine or chlorine. Among these, very particular preference is given to those compounds of the formula (I), in which Ar represents phenyl which may be substituted by 1 or 2 substituents, where the substituents are selected independently of one another from the group consisting of methyl, methoxy, fluorine and chlorine, R1 represents hydrogen or methoxy, R2 represents hydrogen, R3 represents methyl, tert-butyl, chlorine or trifluoromethyl, R4 represents hydrogen, R5 represents hydrogen, R6 represents aminocarbonyl or fluorine, R7 represents hydrogen and R8 represents hydrogen or fluorine. Preference is also given to those compounds of the formula (I), in which R1 represents hydrogen, methyl, methoxy or fluorine. Among these, particular preference is given to those compounds of the formula (I), in which R1 represents methoxy. Preference is also given to those compounds of the formula (I) in which R1 is attached to the phenyl ring via the position ortho to the point of attachment of the phenyl ring. For the purposes of the present invention, the point of attachment of the phenyl ring substituted by radicals R1, R2 and R3 is to be understood as meaning the carbon'atom of the phenyl ring which, according to formula (I), is attached to one of the two nitrogen atoms of the dihydroquinazoline. Particular preference is given to those compounds of the formula (I), in which R1 represents methoxy and R1 is attached to the phenyl ring via the position ortho to the point of attachment of the phenyl ring. Preference is also given to those compounds of the formula (I) in which R2 represents hydrogen. Preference is also given to those compounds of the formula (I) in which R3 represents trifluoromethyl, chlorine, methyl, isopropyl or tert-butyl. Among these, particular preference is given to those compounds of the formula (I) in which R3 represents trifluoromethyl, chlorine or methyl. Among these, very particular preference is given to those compounds of the formula (I) in which R3 represents trifluoromethyl. Preference is also given to those compounds of the formula (I) in which R1 is attached to the phenyl ring via the position ortho to the point of attachment of the phenyl ring and R3 is attached to the phenyl ring via the position meta to the point of attachment of the phenyl ring, which position is opposite to that of R1. Particular preference is given to those compounds of the formula (I) in which R1 is attached to the phenyl ring via the position ortho to the point of attachment of the phenyl ring, R3 represents trifluoromethyl, chlorine or methyl and R3 is attached to the phenyl ring via the position meta to the point of attachment of the phenyl ring, which position is opposite to that of R1. Among these, particular preference is given to those compounds of the formula (I) in which R1 is attached to the phenyl ring via the position ortho to the point of attachment of the phenyl ring, R3 represents trifluoromethyl and R3 is attached to the phenyl ring via the position meta to the point of attachment of the phenyl ring, which position is opposite to that of R1. Preference is also given to those compounds of the formula (I) in which R4 and R5 represent hydrogen. Preference is also given to those compounds of the formula (I) in which R6 represents fluorine. Particular preference is given to those compounds of the formula (I) in which R6 represents fluorine and R6 is, as described in formula (Formula Removed) attached to the aromatic radical of the dihydroquinazoline. Preference is also given to those compounds of the formula (I) in which R7 represents hydrogen. Among these, particular preference is given to those compounds of the formula (I) in which R8 represents hydrogen, methyl or fluorine. Among these, very particular preference is given to those compounds of the formula (I) in which R8 represents hydrogen. Preference is also given to those compounds of the formula (I) in which Ar represents phenyl which may be substituted by 1 or 2 substituents, where the substituents are selected independently of one another from the group consisting of methyl, methoxy, fluorine and chlorine. The particular radical definitions given in the respective combinations or preferred combinations of radicals are, independently of the combinations of radicals given in each case, also replaced by radical definitions of other combinations. Very particular preference is given to combinations of two or more of the preferred ranges mentioned abore. The invention furthermore provides a process for preparing me uumpuiuius of the formula (I), which comprises reacting compounds of the formula (Formula Removed) in which AT, R1, R2, R3, R4, R5i R6, R7 and R8 are as defined above and R9 represents alkyl, preferably methyl or ethyl or tert-butyl, with bases or acids. In the case of methyl and ethyl, the reaction is generally carried out using bases in inert solvents, preferably in a temperature range of from room temperature to the reflux temperature of the solvent, at atmospheric pressure. Suitable bases are, for example, alkali metal hydroxides, such as sodium hydroxide, lithium hydroxide or potassium hydroxide, or alkali metal carbonates, such as caesium carbonate, sodium carbonate or potassium carbonate, if appropriate in aqueous solution; preference is given to sodium hydroxide in water. . Inert solvents are, for example, ethers, such as 1,2-dimethoxyethane, dioxane, tetrahydrofuran, glycol dimethyl ether or diethylene glycol dimethyl ether, alcohols, such as methanol, ethanol, n-propanol, isopropanol, n-butanol or tert-butanol, or mixtures of solvents; preference is given to dioxane or tetrahydrofuran. In the case of tert-butyl, the reaction is generally carried out using acids in inert solvents, preferably in a temperature range of from 0°C to 40°C, at atmospheric pressure. Here, suitable acids are hydrogen chloride in dioxane, hydrogen bromide in acetic acid or trifluoroacetic acid in methylene chloride. The compounds of the formula (II) are known or can be prepared by reacting compounds of the formula (Formula Removed) in which R6, R', R8 and Ry are as defined above in a two-step reaction initially with compounds of the formula (Formula Removed) in which R , R and R are as defined above and then with compounds of the formula (Formula Removed) in which Ar, R4 and R5 are as defined above. Both steps of the reaction are generally carried out in inert solvents, preferably in a temperature range of from room temperature to 100°C, at atmospheric pressure. In the second step, if appropriate, silica gel is added to the reaction mixture. The reaction is preferably carried out with vork-up between the first and the second step. Suitable inert solvents are, for example, halogenated hydrocarbons, such as methylene chloride, trichloromethane, carbon tetrachloride, trichloroethane, tetrachloroethane, 1,2-dichloroethane or trichloroethylene, ethers, such as diethyl ether, methyl tert-butyl ether, 1,2-dimethoxyethane, dioxane, tetrahydrofuran, glycol dimethyl ether of diethylene glycol dimethyl ether, hydrocarbons, such as benzene, xylene, toluene, hexane, cyclohexane or mineral oil fractions, or other solvents, such as dimethylformamide, dimethylacetamide, acetonitrile or ethyl acetate, or mixtures of solvents; preference is given to methylene chloride. The compounds of the formula (IV) are known or can be synthesized by known processes from the corresponding starting materials. The compounds of the formula (V) are known or can be synthesized by known processes from the corresponding starting materials, for example by a Buchwald-Hartwig reaction according to the synthesis scheme below (review in: C.G. Frost, P. Mendonca, J. Chem. Soc., Perkin Trans 1,1998, 2615-2623): Buchwald-Hartwig reaction: (Formula Removed) The starting materials required for this purpose are known or can be synthesized by known processes from the corresponding starting materials. The compounds of the formula (HI) are known or can be prepared by reacting compounds of the formula (Formula Removed) in which R6 , R7 , R8 and R9 are as defined above with triphenylphosphine and carbon tetrachloride. The reaction is generally carried out in inert solvents, in the presence of a base, preferably in a temperature range of from room temperature to 50°C, at atmospheric pressure. Suitable inert solvents are, for example, ethers, such as diethyl ether, methyl tert-butyl ether, 1,2-dimethoxyethane, dioxane, tetrahydrofuran, glycol dimethyl ether or diethylene glycol dimethyl ether, hydrocarbons, such as benzene, xylene, toluene, hexane, cyclohexane or mineral oil fractions, or other solvents, such as dimethylformamide, dimethylacetamide, acetonitrile or pyridine; preference is given to acetonitrile. Suitable bases are, for example, alkali metal and alkaline earth metal carbonates, such as caesium carbonate, sodium carbonate or potassium carbonate, or amines, such as triethylamine, diisopropylethylamine, N-methylmorpholine or pyridine; preference is given to triethylamine. The compounds of the formula (VI) are known or can be synthesized by known processes from the corresponding starting materials, for example by a Heck reaction or a Wittig-Homer reaction, according to the synthesis schemes below: Heck reaction: (Formula Removed) Wittig-Horner reaction: (Formula Removed) The starting materials required for this purpose are known or can be synthesized by known processes from the corresponding starting materials. The preparation of the compounds according to the invention can be illustrated by the synthesis scheme below. Synthesis scheme: (Formula Removed) The compounds of the general formula (I) according to the invention show a surprising range of effects which could not have been predicted. They show an antiviral effect on representatives of the group of the Herpes viridae (Herpes viruses), especially on cytornegalo viruses (CMV), in particular, on human cytomegalovirus (HCMV). tt. Areas of indication which may be mentioned by way of example are: 1) Treatment and prophylaxis of HCMV infections in AIDS patients (retinitis, pneumonitis, gastrointestinal infections). 2) Treatment and prophylaxis of cytomegalovirus infections in bone-marrow and organ transplantations which develop often life-threatening HCMV pneumonitis or encephalitis, and gastrointestinal and systemic HCMV infections. 3) Treatment and prophylaxis of HCMV infections in neonates and infants. 4) Treatment of an acute HCMV infection in pregnant women. Treatment of HCMV infection in immunosuppressed patients associated with cancer and cancer therapy. 6) Treatment of HCMV-positive cancer patients with the aim to reduce HCMV-mediated rumour progression (cf. J. Cinatl, et al., FEMS Microbiology Reviews 2004, 28, 59-77). The present invention further provides the use of the compounds according to the invention for the treatment and/or prophylaxis of diseases, especially of infections with viruses, in particular the viruses mentioned above, and the infective diseases caused by these infections. Hereinbelow, a viral infection is to be understood as including both an infection with a virus and a disease caused by an infection with a virus. The present invention also provides the use of the compounds according to the invention for the treatment and/or prophylaxis of disorders, in particular the disorders mentioned above. The present invention also provides the use of the compounds according to the invention for preparing a medicament for the treatment and/or prophylaxis of disorders, in particular the disorders mentioned above. The compounds according to the invention are preferably used for preparing medicaments suitable for the prophylaxis and/or treatment of infections with a representative of the group of the Herpes viridae, in particular a cytomegalovirus, in particular the human cytomegalovirus. The present invention also provides a method for the treatment and/or prophylaxis of disorders, in particular the disorders mentioned above, using an antivirally effective amount of the compounds according to the invention. The present invention also provides medicaments comprising at least one compound according to the invention and at least one or more further active compounds, in particular for the treatment and/or prophylaxis of the disorders mentioned above. Active compounds suitable for combinations are, by way of. example and preferably: antiviral active compounds, such as gancyclovir or acyclovir. The compounds according to the invention can act systemically and/or locally. For this purpose, they can be administered in a suitable way, such as, for example, by the oral, parenteral, pulmonary, nasal, sublingual, lingual, buccal, rectal, dermal, transdermal, conjunctival or otic route, or as implant or stent. For these administration routes, it is possible to administer the compounds according to the invention in suitable administration forms. uitable for oral administration are known administration forms which deliver the compounds according to the invention rapidly and/or in modified form and which comprise the compounds according to the invention in crystalline and/or amorphous and/or dissolved form, such as, for example, tablets (uncoated or coated tablets, for example tablets provided with enteric coatings or coatings which dissolve slowly or are insoluble and which control the release of the compound according to the invention), tablets which disintegrate rapidly in the oral cavity and/or films/wafers, films/lyophylisates, capsules (for example Hart or soft gelatin capsules), sugar-coated tablets, granules, pellets, powders, emulsions, suspensions, aerosols or solutions. Parenteral administration can take place with avoidance of an adsorption step (for example intravenously, intraarterially, intracardially, inrraspinally or intralumbally) or with inclusion of absorption (for example intramuscularly, subcutaneously, intracutaneously, percutaneously or intraperitoneally). Administration forms suitable for parenteral administration are, inter alia, preparations for injection and infusion in the form of solutions, suspensions, emulsions, lyophilisates or sterile powders. Examples suitable for other administration routes are, for example, pharmaceutical forms for inhalation (inter alia powder inhalers, nebulizers), nasal drops/solutions/sprays; tablets to be administered lingually, sublingually or buccally, films/wafers or capsules, suppositories, preparations for the eyes or ears, vaginal capsules, aqueous suspensions (lotions, shaking mixtures), lipophilic suspensions, ointments, creams, transdermal therapeutic systems, milk, pastes, foams, dusting powders, implants or stents. The compounds according to the invention can be converted into the stated administration forms. This can take place in a known manner with the mixing of inert, non-toxic, pharmaceutically acceptable auxiliaries. These auxiliaries include, inter alia, carriers (for example microcrystalline cellulose, lactose, mannitol), solvents (for example liquid polyethylene glycols), emulsifiers and dispersants or wetting agents (for example sodium dodecyl sulphate, polyoxysorbitan oleate), binders (for example polyvinylpyrrolidone), synthetic and natural polymers (for example albumin), stabilizers (for example antioxidants such as ascorbic acid), colorants (for example inorganic pigments such as iron oxides) and flavour- and/or odour-masking agents. The present invention furthermore provides medicaments comprising at least one compound according to the invention, usually together with one or more inert, non-toxic, pharmaceutically acceptable auxiliaries, and their use for the purposes mentioned above. In general, it has proved advantageous to administer on intravenous administration amounts of about 0.001 to l0mg/kg, preferably about 0.01 to 5 mg/kg, of body weight to achieve effective results, and the dosage on oral administration is about 0.01 to 25 mg/kg, preferably 0.1 to 10 mg/kg, of body weight. It may nevertheless be necessary where appropriate to deviate from the amounts mentioned, specifically as a function of the body weight, administration route, individual response. to the active compound, mode of preparation and time or interval over which administration takes place. Thus, it may be sufficient in some cases to make do with less than the aforementioned minimal amount, whereas in other cases the upper limit mentioned must be exceeded. It may in the event of administration of larger amounts be advisable to divide these into a plurality of individual doses over the day. The percentage data in the following tests and examples are percentages by weight unless otherwise indicated; parts or parts by weight. Solvent ratios, dilution ratios and concentration data of liquid/liquid solutions are in each case based on volume. A. Examples Abbreviations: BMAP 2,2'-bis(diphenylphosphino)-l,l'-binaphthyl CDC13 deuterated chloroform . DCI direct chemical ionization (in MS) DCM dichloromethane DEEA N.Af-diisopropylethylarnine DMSO dimethyl sulphoxide DMF N,N-dimethylformamide EA ethyl acetate El electron impact ionization (in MS) ESI electrbspray ionization (in MS) h hour HPLC high-pressure, high-performance liquid chromatography LC-MS liquid-chromatography-coupled mass spectroscopy LDA lithium diisopropylamide min minutes m.p. melting point MS mass spectroscopy MTBE methyl tert-butyl ether NMR nuclear magnetic resonance spectroscopy Pd-C palladium-on-carbon RP-HPLC reverse phase HPLC RT room temperature R, retention time (in HPLC) THF tetrahydrofuran TLC Thin-layer chromatography Method 1 (analytical HPLC): column: Kromasil CIS 60 mm x 2 mm; temperature: 30°C; flow rate: 0.75 ml/min; mobile phase A: 0.005 M HC1O4, mobile phase B: acetonitrile; gradient: 0.5 min 98%A,  4.5 min 10%A, 6.5 min 10%A. Method 2 (preparative HPLC): column: GromSil C18, 250 mm x 30 mm; flow rate: 50 ml/min; time per run: 38 min; detection: 210 nm; mobile phase A: water, mobile phase B: acetonitrile; gradient: 10%B (3 min) → 90%B (31 min) → 90%B (34 min) → 10%B (34.01 min). Method 3 (LC-MS): column: GromSil 120 ODS-4 HE, 50 mm x 2.0 mm, 3 /im; mobile phase A: 11 of water + 1 ml of 50% strength formic acid, mobile phase B: 11 of acetonitrile + 1 ml of 50% strength formic acid; gradient: 0.0 min 100%A -» 0.2 min 100%A → 2.9 min 30%A→ 3.1 min 10%A  4.5 min 10%A; oven: 55°C; flow rate: 0.8 ml/min; UV detection: 208-400 nm. Method 4 (preparative HPLC, separation of enantiomers, carboxylic acids): column: packing chiral silica gel selector KBD 8361 (420 mm x 100 mm) based on the selector poly(N-methacryloyl-L-leucine-l-menthylamide); temperature: 23°C; mobile phase:-methyl tert-butyl ether; flow rate: 100 ml/min; the compound is dissolved in methyl tert-butyl ether/ethyl acetate (9:1). Method 5 (preparative HPLC): column: GromSil CIS, 250 mm x 30 mm; flow rate: 50 ml/min; time per run: 38 min; detection: 210 nm; mobile phase A: water with 0.1% formic acid, mobile phase B: acetonitrile; gradient: 10%B (3 min) -> 90%B (31 min) -> 90%B (34 min) -> 10%B (34.01 min). Method 6 (analytical HPLC): instrument: HP 1100 with DAD detection; column: Kromasil RP-18, 60 mm x.J2 mm, 3.5/Am; mobile phase A: 5 ml of HC104/1 of water, mobile phase B: acetonitrile; gradient: 0 min 2%B, 0.5 min 2%B, 4.5 min 90%B, 9 min 90%B; flow rate: 0.75 mVmin; temp.: 30°C; detection: UV 210 nm. Method 7 (LC-MC): instrument: Micromass Platform LCZ with HPLC Agilent series 1100; column: Grom-SIL120 ODS-4 HE, 50 mm x 2.0 mm, 3 /Am; mobile phase A: 11 of water + 1 ml of 50% strength formic acid, mobile phase B: 11 of acetonitrile + 1 ml of 50% strength formic acid; gradient: 0.0 min 100%A→ 0.2 min 100%A → 2.9 min 30%A → 3.1 min 10%A → 4.5 min 10%A; oven: 55°C; flow rate: 0.8 ml/min; UV detection: 210 nm. Method 8 (LC-MC): instrument: Micromass Platform LCZ, HP1100; column: Symmetry C18, 50 mm x 2.1 mm, 3.5 /im; mobile phase A: acetonitrile + 0.1% formic acid, mobile phase B: water - 0.1% fonnic acid; gradient: 0.0 min 10%A → 4.0 min 90%A → 6.0 min 90%A; oven: 40°C; flow rate: 0.5 ml/min; UV detection: 208-400 nm. Method 9 (LC-MC): MS instrument: Micromass ZQ; HPLC instrument: Waters Alliance 2795; column: Merck Chromolith SpeedROD RP-18e 50 mm x 4.6 mm; mobile phase A: water + 500 µl of 50% strength formic acid/1, mobile phase B: acetonitrile + 500 ul of 50% strength formic acid/1; gradient: 0.0 min 10%B → 3.0 min 95%B → 4.0 min 95%B; oven: 35°C; flow rate: 0.0 min 1.0 ml/min  3.0 min 3.0 ml/min 4.0 min 3.0 ml/min; UV detection: 210 nm. Method 10 (LC-MC): MS instrument: Mieromass ZQ; HPLC instrument: HP 1100 Series; UV DAD; column: Grom-Sil 120 ODS-4 HE 50 mm x 2 mm, 3.0 /im; mobile phase A: water + 500 ul of 50% strength formic acid/1, mobile phase B: acetonitrile + 500 ul of 50% strength formic acid/1; gradient: 0.0 min 0%B  2.9 min 70%B  3.1 min 90%B 4.5 min 90%B; oven: 50°C; flow rate: 0.8 ml/min; UV detection: 210 nm. Method 11 (preparative HPLC, separation of enantiomers): column: packing chiral silica gel selector KBD 8361 (250 mm x 20 mm) based on the selector poly(N-methacryloyl-L-leucine-l-menthylamide); temperature: 23°C; mobile phase: methyl tert-butyl ether + 5% ethyl acetate; flow rate: 25 ml/min. Method 12 (preparative HPLC, separation of enantiomers): column: packing chiral silica gel selector KBD 5326 (250 mm x 20 mm) based on the selector poly(N-methacryloyl-L-leucine-dicyclopropylmethylamide); temperature: 23°C; mobile phase: methyl tert-butyl ether + 5% ethyl acetate; flow rate: 25 ml/min. Method 13 (preparative HPLC, separation of enantiomers): column: packing chiral silica gel selector KBD 8361 (250 mm x 20 mm) based on the selector poly(N-methacryloyl-L-leucine-l-menmylamide); temperature: 23°C; mobile phase: methyl tert-butyl ether; flow rate: 25 ml/min. Method 14 (preparative HPLC, separation of enantiomers, esters): column: packing chiral silica gel selector KBD 8361 (420 mm x 100 mm) based on the selector poly(N-methacryloyl-L-leucine-1-menthylamide); temperature: 23°C; mobile phase: isohexane/ethyl acetate 85/15 v/v; flow rate: 100 ml/min; the compound is dissolved in isohexane/ethyl acetate (85:15). Method 15 (preparative HPLC, separation of enantiomers, esters): column: packing chiral silica gel selector KBD 8361 (420 mm x 100 mmj-based on the selector poly(N-methacryloyl-L-_ leucine-1-menthylamide); temperature: 23°C; mobile phase: methyl tert-butyl ether; flow rate: 100 ml/min; the compound is dissolved in methyl tert-butyl ether. "lethod 16 (LC-MS): instrument: Micromass Platfonn LCZ with HPLC Agilent Series 1100; column: Grom-SIL120 ODS-4 HE, 50 mm x 2.0 mm, 3 µm; mobile phase A: 11 of water + 1 ml of 50% strength formic acid, mobile phase B: 1 1 of acetonitrile + 1 ml of 50% strength formic acid; gradient: 0.0 min 100%A → 0.2 min 100% A → 2.9 min 30%A → 3.1 min 10%A → 4.5 min 10%A; oven: 55°C; flow rate: 0.8 ml/min; UV detection: 208^00 nm. Method 17 (LC-MS): MS instrument: Micromass ZQ; HPLC instrument: Waters Alliance 2790; column: Grom-Sil 120 ODS-4 HE 50 mm x 2 mm, 3.0 /mi; mobile phase A: water + 500 µl of 50% strength formic acid/1, mobile phase B: acetonitrile + 500 ul of 50% strength formic acid/1; gradient: 0.0 min 0%B→ 0.2 min 0%B→ 2.9 min 70%B→ 3.1 min 90%B→ 4.5 min 90%B; oven: 45°C; flow rate: 0.8 ml/min; UV detection: 210 nm. Starting materials General procedure [A]: Synthesis of substituted 2-aminocinnamic acid derivatives by Heck coupling from 2-halo-substituted anilines In a one-necked flask, 1.0 equivalent of an aryl halide is initially charged with 1.6 equivalents of methyl acrylate or tert-butyl acrylate, 2.0 equivalents of triethylamine, 0.03 equivalents of palladium(n) acetate and 0.03 equivalents of tri-o-tolylphosphine in acetonitrile (solution about 1M). The mixture is stirred under reflux for 48 hours. After the reaction has ended (the reaction is monitored by TLC), the solvent is removed. The residue is purified chromatographically on silica gel using cyclohexane/ethyl acetate - 8:2 v/v. Example 1A Methyl (2E)-3-[2-amino-3-fluorophenyl]propenoate (Formula Removed) Starting with 42.00 g (221.04 mmol) of 2-bromo-6-fiuoroaniline, the general procedure [A] gives 29.66 g (68% of theory) of product. HPLC (Method 1): R,= 4.14 min MS(ESI-pos):m/z=196(M+H)+ . Example 2A Methyl 2-arnino-3-[(lE)-3-methoxy-3-oxo-l-propenyl]benzoate (Formula Removed) Starting with 2.00 g (8.69 mmol) of methyl 2-amino-3-bromobenzoate, the general procedure [A] gives 1.29 g (60% of theory) of product. HPLC (Method 1): Rt= 4.42 min MS (ESI-pos): m/z = 236 (M+H)+ Example 3 A Methyl (2E)-3-(2-amino-3,5-difluorophenyl)-2-propenoate (Formula Removed) Starting with3.00 g (14.42 mmol) of 2-bromo-4,6-difluoroaniline, the general procedure [A] gives 1.41 g (45% of theory) of product. HPLC (Method 1): Rt= 4.23 min MS (ESI-pos): m/z = 214 (M+H)+ Example 4A Methyl 4-amino-3-[(7£)-3-methoxy-3-oxo-l-propenyl]benzoate (Formula Removed) Starting with 25.00 g (90.23 mmol) of methyl 4-amino-3-iodobenzoate, the general procedure [A] gives 24.31 g (92% of theory) of product. HPLC (Method 1): R,= 4.71 min MS (ESI-pos): m/z = 278 (M+H)+ Example 5A Methyl (2E)-3-[2-amino-5-cyanophenyl]-2-propenoate (Formula Removed) Starting with 1.90 g (9.64 mmol) of 3-bromo-4-aminobenzonitrile, the general procedure [A] gives 1.28 g (50% of theory) of product. HPLC (Method 1): R,= 2.85 min MS (DCI-pos): m/z = 220 {M+NH4)+ General procedure [B1: Synthesis of substituted 2-nitrocinnamic acid derivatives by Wittig-Horner reaction from 2-halo-substituted benzaldehydes In a 100 ml one-necked flask, 27.5 mmol of methyl diethyl phosphonoacetate, 25.0 mmol of the benzaldehyde and 27.5 mmol of lithium hydroxide are suspended in tetrahydrofuran. After the reaction has ended (the reaction is monitored by TLC), the reaction mixture is mixed with the same volume of water. The aqueous phase is extracted three times with ethyl acetate. The combined organic phases are washed with saturated sodium chloride solution and dried over sodium sulphate, and the solvent is removed. The product is dried under high vacuum at RT, without further purification. If the product is very impure, it is, if appropriate, purified by column ohromatography on silica gel using cyclohexane/ethyl acetate. Example 6A Methyl (2E)-3-(3-methoxy-2-nitrophenyl)-2-propenoate (Formula Removed) Starting with 2.00 g (11.04 rnmol) of 3-methoxy-2-nitrobenzaldehyde, the general procedure [B] gives 2.46 g (92% of theory) of product. HPLC (Method 1): R»= 4.37 min MS (ESI-pos): m/z = 238 (M+H)+ Example 7A Methyl (2E)-3 -(5 -fluoro-2 -nitrophenyl)-2-propenoate (Formula Removed) Starting with 20.0 g (118.3 rnmol) of 5-fluoro-2-nitrobenzaldehyde, the general procedure [B] gives 7.25 g (27% of theory) of product. MS (DCI): m/z = 243 (M+NK,)* General procedure fCI: Preparation of a 2-nitrobenzaldehyde from a benzyl halide 10.0 rnmol of the benzyl halide, 4.1 g of molecular sieve 4A and 20.0 mmol of N-methylmorpholine N-oxide are suspended in 45 ml of acetonitrile. The mixture is stirred at RT until the reaction has gone to completion (the reaction is monitored by TLC). After the reaction has ended, the molecular sieve is filtered off, the solvent is removed and the residue is taken up jain in ethyl acetate. This solution is initially washed with IN hydrochloric acid and then with saturated sodium chloride solution. The organic phase is separated off and then dried over sodium sulphate, and the solvent is again removed. Analysis shows that the crude product is sufficiently pure and can directly be reacted further. Example 8A 2-Fluoro-6-nitrobenzaldehyde (Formula Removed) Starting with 2.00 g (8.55 mmol) of 3-fluoro-6-nitrobenzyl bromide, the general procedure [C] gives 1.09 g (75% of theory) of product. HPLC (Method 1): R,= 3.58 min General procedure [D1; Reduction of the nitro group of the 2-nitrociimamic acid derivatives Under argon, 25 mmol of the nitro compound and 125 mmol of tin(II) chloride dihydrate are initially charged in 60 ml of absolute ethanol in a 250 ml two-necked flask. This suspension is stirred under reflux for 30 minutes, and a clear solution is formed. The solution is then cooled to room temperature and subsequently poured onto ice-water. Using either solid sodium bicarbonate or a saturated sodium carbonate solution, the pH is adjusted to pH=7-8. 60 ml of ethyl acetate are then added, and the precipitated tin salts are filtered off through kieselguhr (a layer of a thickness of about 1 cm). The organic phase is separated off and the aqueous phase is re-extracted with ethyl acetate. The organic phases are combined, washed once with saturated sodium chloride solution and dried over sodium sulphate, and the solvent is concentrated to about half of its original volume. Activated carbon corresponding to 1% of the weight of the nitro compound is then added, and the mixture is heated under reflux for 30 minutes (the colour of the solution changes). The activated carbon is filtered off and the solvent is removed. The residue obtained is an oil which, on drying at RT under high vacuum, forms crystals. Without further purification, the product is directly used for the next step. Example 9 A Methyl 3-[2-amino-6-fluorophenyl]propenoate (Formula Removed) Starting with 7.25 g (32.2 mmol) of the nitro compound from Example 7A, the general procedure [D] gives 5.0 g (58% of theory) of product. HPLC (Method 1): R,= 3.33 min General procedure fEI: Synthesis of the iminophosphoranes by Appel reaction of the substituted anilines hi a 50 ml one-necked flask, 10.0 mmol of the amine of the 2-aminocinnamic ester, 20.0 mmol of triphenylphosphine, 100.0 mmol of carbon tetrachloride and 100.0 mmol of triethylamine are dissolved in 20 ml of acetonitrile. The mixture is stirred at room temperature for 2 hours. After the reaction has ended (the reaction is monitored by TLC or analytic HPLC), the solvent is removed under reduced pressure and the residue is purified by column chromatography on silica gel using cyclohexane/ethyl acetate = 7:3. Example 10A Methyl (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}propenoate (Formula Removed) Starting with 29.3 g (150.1 mmol) of the amine compound from Example 1A, the general procedure [E] gives 55.0 g (80% of theory) of product. (Formula Removed) Example 11A Methyl (2E)-3-{5-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}propenoate (Formula Removed) Starling with 50.0 g (256.2 mmol) of the amine compound from Example 9A, the general procedure [E] gives 89.6 g (77% of theory) of product. HPLC (Method 1): R, = 4.36 min MS (ESI-pos): m/z = 456 (M+H)+ Example 12A Starting with 1.24 g (4.60 mmol) of the amine compound from Example 5 A, the general procedure Methyl (2E)-3-{5-cyano-2-[(triphenylphosphoranylidene)amino]phenyl}propenoate (Formula Removed) rE] gives 2.12 g (92% of theory) of product. HPLC (Method 1): Rt = 4.42 min MS (ESI-pos): m/z = 463 (M+H)* General procedure rFI; Synthesis of phenylpiperazines by the Buchwald-Hartwig reaction To prepare for the reaction, the reaction flask is thoroughly dried by heating under high vacuum and vented with argon. 1.0 equivalent of the bromoaryl compound and 6.0 equivalents of piperazine in absolute toluene are initially charged in the flask (0.2-0.3M solution of the bromo compound). 0.01 equivalent of tris(dibenzylideneacetone)dipalladium and 0.03 equivalent of BINAP are then added. The reaction mixture is stirred under reflux for 16 h. The mixture is then extracted once with water, the organic phase is extracted twice with IN hydrochloric acid and the aqueous phase is adjusted to pH 8 using IN aqueous sodium hydroxide solution and extracted three times with dichloromethane. The combined organic phases are dried over sodium sulphate and filtered, the solvent is removed under reduced pressure and the product is dried under high vacuum overnight. Example 13A N-(4-Fluoro-3-methylphenyl)piperazine (Formula Removed) Starting with 5.0 g (26.5 mmol) of 4-fluoro-3-methyl-1-bromobenzene, the general procedure [F] gives 4,52 g (83% of theory) of product. HPLC (Method 1): R,= 3.54 min MS (ESI pos): m/z = 195 (M+H)+ Example 14A N-(4-Fluorophenyl)-3-methylpiperazine (Formula Removed) Starting with 1.0 g (5.71 rnmol) of 4-fluoro-3-methyl-l-bromobenzene, the general procedure [F] gives 0.57 g (49% of theory) of product. HPLC (Method 1): R,= 3.37 rnin MS (DCI pos): m/z = 195 (M+H)+ Example ISA 1-(3-Fluorophenyl)piperazine (Formula Removed) 1 g (5.71 mmol) of 3-fluorobromobenzene and 2.95 g (34.29 rnmol) of piperazine are dissolved in 20 ml of toluene, and 0.77 g (8 mmol) of sodium tert-butoxide is added. In the presence of 0.11 g (0.17 mmol) of BENAP and 0.05 g (0.06 mmol) of tris(diben2ylideneacetone)dipalladium, the mixture is then stirred under reflux overnight. After cooling, ethyl .acetate is added and the mixture is washed with water. The mixture is then extracted with IN hydrochloric acid, and the aqueous phase is washed with ethyl acetate. The pH is adjusted to 8-9 and the mixture is then extracted with dichloromethane. The organic phase is dried over magnesium sulphate and the solvent is removed, giving the target compound. Yield: 0.8 g (78% of theory) HPLC (Method 1): Rt= 3.4 min MS (ESI-pos): m/z = 181 (M+H)+ Example 16A 1 -(3,4-Difluorophenyl)piperazine (Formula Removed) In 100 ml of toluene, 5 g (25.91 minol) of 3,4-difluorobromobenzene, 13.39 g (155.45 mmol) of piperazine, 3.49 g (36.27 mmol) of sodium tert-butoxide, 0.24 g (0.26 mmol) of tris(dibenzylidene-acetone)dipalladium and 0.48 g (0.78 mmol) of BINAP are stirred under reflux overnight. Ethyl acetate is added, the mixture is then washed with water and the organic phase is extracted with IN hydrochloric acid. The aqueous phase is then washed with ethyl acetate and subsequently adjusted to pH 8. Using dichloromethane, the product is extracted from the aqueous phase. The extract is then dried over magnesium sulphate, the solvent is removed and the target compound is dried under reduced pressure. Yield: 3.85 g (75% of theory) HPLC (Method 1): R»= 3.4 min MS (DO): m/z = 199 (M+H)+ Example 17A 2-Isocyanato-l-methoxy-4-(trifluoromethyl)benzene (Formula Removed) 3g (15.69 mmol) of 2-methoxy-5-trifluoromethylaniline are dissolved in 100ml of dichloromethane, and 6.73 g (31.39 mmol) of l,8-bis(dimethylamino)naphthalene are added. At 0-5°C, 2.24 g (11.3 mmol) of trichloromethyl chloroformate, dissolved in 50ml of dichloromethane, are added dropwise, and the mixture is stirred at 0°C for 30 min and then at room temperature for 60 man. At 0°C, the mixture is washed with IN hydrochloric acid, ice-water and sodium bicarbonate solution. Drying over magnesium sulphate and removal of the solvent by distillation gives the product. The isocyanate is then used for the subsequent reactions without further purification. Yield: 3.00 g (88% of theory) Example ISA Methyl (2E)-3-{3-fluoro-2-[({[2-methoxy-5-(trifluoromethyl)phenyl]imino}methylene)ammo]-phenyl} -2-propenoate (Formula Removed) 5.0 g (10.98 mmol) of methyl (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-2-propenoate (Example 10A) are initially charged in 50 ml of dichloromethane, and the mixture is stirred with 2.5 g (11.53 mmol) of 2-isocyanato-l-methoxy-4-(trifluoromethyl)benzene (Example 17A) at room temperature overnight. The solvent is removed by distillation and the product is then purified by chromatography on silica gel (isohexane/dichloromethane 2:1; 1:1) and recrystallized fromisohexane. Yield: 2.69 g (62% of theory) HPLC (Method 1): PM= 5.6 min MS (ESI-pos): m/z = 395 (M+H)+ General procedure [G]: Reaction of the iminophosphorane with an isocyanate and subsequent reaction with an amine to give the dihydroquinazoline derivative 1.0 equivalent of the iminophosphorane is dissolved in 20ml of dichloromethane (0.1-0.2M solution). 1.05 equivalents of a substituted isocyanate are then added, and the mixture is stirred at RT until the reaction has ended. The reaction is monitored by TLC or by analytical HPLC. 1.0 equivalent of amine and a spatula tip of silica gel are then added to the resulting solution of the carbodiimide and dichloromethane, and the mixture is stirred at room temperature until the reaction has gone to completion. After the reaction has ended (reaction is monitored by TLC or HPLC), the mixture is concentrated and purified by preparative HPLC on an RP phase. In certain cases, the NMR shows the presence of a varying proportion of non-cyclized reaction product. In those cases, the mixture of cyclized and non-cyclized product is taken up in dioxane, a spatula tip of silica gel is added and the mixture is stirred under reflux for 30 min to 16 h. The silica gel is filtered off and the solution is used for further reactions. If it is intended to produce enantiomericaHy pure compounds, the chromatographic separation is carried out at this stage. Example 19A Methyl {8-fluoro-2-[4-(4-fluorOphenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) Starting with 92.5 mg (0.2 mmol) of the iminophosphorane from Example 10A, the general procedure [G] gives 50 mg (45% of theory) of product. HPLC (Method 1): Rt = 4.81 min ixample 20A Methyl {8-fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl) acetate (Formula Removed) This compound is obtained as enantiomer A following the separation of enantiomers of 3.84 g of Example 19A (715 mg, 14% of theory). HPLC (Method 1): R, = 4.81 min MS (ESI-pos): m/z = 544.9 (M+H)+ Example 21A Methyl {6-fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-t3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) Starting with 100 mg (0.28 mmol) of the iminophosphorane from Example 11A, the general procedure [G] gives 58 mg (39% of theory) of product. Example 22A Methyl { 4-quinazolinyl} acetate (Formula Removed) This compound is obtained as enantiomer A following the separation of enantiomers of 832 mg of Example 21A (368 mg, 17% of theory). HPLC (Method 1): Rt = 4.77 min MS (ESI-pos): m/z = 544.9 (M+H)+ Example 23A Starting with 93 mg (0.2 mmol) of the iminophosphorane from Example 10A, the general Methyl {8-fluoro-2-t4-(3'methylphenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) ocedure [G] gives 43 mg (39% of theory) of product. HPLC (Method 1): R, = 4.80 min MS (ESI-pos): m/z = 541.0 (M+Hf Example 24A Methyl {8-fluoro-2-[4-(3-methylphenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) This compound is obtained as enantiomer A following the separation of enantiomers of 3.31 g of Example 23 A (1.18 g, 22% of theory). HPLC (Method 1): Rt = 4.80 min MS (ESI-pos): m/z =' 541.0 (M+H)+ Example 25A Methyl {8-fluoro-2-[4-(3-methoxyphenyl)-l-piperazmyl]-3-[3-(trifluoromethyl)phenyl]-3,4- dihydro-4-quinazolinyl} acetate (Formula Removed) Starting with 93 mg (0.2 mmol) of the iminophosphorane from Example 10A, the general procedure [G] gives 51 mg (45% of theory) of product. HPLC (Method 1): Rt = 4.62 min MS (ESI-pos): m/z = 556.7 (M+H)+ Example 26A Methyl {8-fluoro-2-[4-(3-methoxyphenyl)-1 -piperazinyl]-3 -[3 -(trifluoromethyl)phenyl] -3,4- dihydro-4-quinazolinyl} acetate (Formula Removed) This compound is obtained as enantiomer A following the separation of enantiomers of 5.11 g of Example 25A (0.49 g, 9% of theory). HPLC (Method 1): Rt = 4.71 min MS (ESI-pos): m/z = 556.8 (M+H)+ Methyl {8-fluoro-2-[4-(4-fluoro-3-methylphenyl)-l-piperazinyl]-3-[6-methoxy-3-(trifluoro- methyl)phenyl]-3,4-dihydro-4-quinazpliiiyl} acetate (Formula Removed) Starting with 1.0 g (2.2 mmol) of the iminophosphorane from Example 10A, 500 mg (2.31 mmol) of 2-isocyanato-l-methoxy-4-(trifluoromethyl)benzene (Example 17A) and 427 mg (2.2 mmol) of the phenylpiperazine from Example 13 A, 1.03 g (79% of theory) of crude product are obtained following filtration through silica gel (cyclohexane/ethyl acetate 2:1 (v/v)). This product is reacted further without further purification. LC-MS (Method 3): R, - 2.55 min, 2.66 min MS (ESI-pos): m/z = 589.3 (M+H)+ Example 28A Methyl {8-fluoro-2-[4-(4-fluoro-3-methylphenyl)-l-piperazinyl]-3-[6-methoxy-3-methylphenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) tarting with 0.60 g (1.76 mmol) of the iminophosphorane from Example 10A, 376 mg (2.31 mmol) of 2-methoxy-5-methylphenyl isocyanate and 342 mg (1.76 mmol) of the phenylpiperazine from Example 13A, 183mg (16% of theory) of product are obtained after purification by preparative HPLC. HPLC (Method l):Rt = 4.77 min MS (ESI-pos): m/z = 535.2 (M+H)+ Example 29A Methyl {8-flugro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[6-methoxy-3-chlorophenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) Starting with 1.0 g (2.2 mmol) of the iminophosphorane from Example 10A, 423 mg (2.31 mmol) of 2-methoxy-5-chlorophenyl isocyanate and 396 mg (2.2 mmol) of 4-fluorophenylpiperazine, 621 mg (52% of theory) of product are obtained after purification by preparative HPLC. HPLC (Method 1): R, = 4.75 min MS (ESI-pos): m/z = 541.2 (M+H)+ Example 30A Methyl {8-fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihy dro-4-quinazolinyl} acetate (Formula Removed) 550 mg (1.39 mmol) of methyl (2E)-3-{3-fluoro-2-[({[2-methoxy-5-(trifluoromethyl)phenyl]-imino}methylene)amino]phenyl}-2-propenoate (Example 18A) and 251 mg (1.39 mmol) of l-(4-fluorophenyl)piperazine are stirred in the presence of a spatula tip of silica gel in 15 ml of dichloromethane for 1 hour. After 90 hours of stirring under reflux, the product is purified by chromatography on silica gel (dichloromethane, dichloromethane/ethyl acetate 10:1). Yield: 769 mg (96% of theory) HPLC (Method 1): Rt= 4.8 min MS (ESI-pos): m/z = 575 (M+H)+ Example 31A Methyl {8-fluoro-2-[4-(3-methoxyphenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)- phenyl]- 3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) 700mg (1.78mmol) of methyl (2E)-3-{3-fluoro-2-[({[2-methoxy-5-(trifluoromethyl)phenyl]-imino}methylene)amino]phenyl}-2-propenoate (Example ISA), 341 mg (1.78 mmol) of l-(3-methoxyphenyl)piperazine and a spatula tip of silica gel are stirred in 20 ml of dichloromethane at room temperature for one hour and then under reflux for 35 hours. The target compound is obtained after purification on silica gel (dichloromethane, dichloromethane/ethyl acetate 10:1). Yield: 1012 mg (97% of theory) HPLC (Method 6): Rt= 4.8 min MS (ESI-pos): m/z = 587 (M+H)+ Example 32A Methyl {8-fluoro-2-[4-(3,4-difluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)- phenyl]-3,4-dihydro-4-quinazolinyl}acetate (Formula Removed) 700 mg (1.78 mmol) of methyl (2E)-3-{3-fluoro-2-[({[2-methoxy-5-(trifluoromethyl)phenyl]-imino}methylefie)amino]phenyl}-2-propenoate (Example 18A),'* 352 mg (1.78 mmol) of l-(3,4-difluorophenyl)piperazine (Example 16A) and a spatula tip of silica gel are stirred in 20 ml of dichloromethane at room temperature for 1 hour and then under reflux for 20 hours. The target compound is then purified by chromatography on silica gel (dichloromethane, dichloromethane/ ethyl acetate 10:1). Yield: 1027 mg (97% of theory) HPLC (Method 1): Rt= 4.8 min MS (ESI-pos): m/z = 593 (M+H)+ Example 33A Methyl {8-fluoro-2-[4-(3-rnethylphenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydr o-4-quinazolinyl) acetate (Formula Removed) ll.Sg (29.16 mmol) of methyl (2E)-3-{3-fluoro-2-[({[2-methoxy-5-(trifluoromethyl)phenyl]-imino}methylene)amino]phenyl}-2-propenoate (Example 18A), 5.14g (29.16 mmol) of l-(3-methylphenyl)piperazine and a spatula tip of silica gel are stirred in 300 ml of dichloromethane at room temperature for 1 hour and then under reflux for 20 hours. The product is obtained after chromatography on silica gel (dichloromethane, dichloromethane/ethyl acetate 10:1, 5:1). Yield: 15.8 g (95% of theory) HPLC (Method 1): R,= 4.8 min MS (ESI-pos): m/z = 571 (M+Hf Example 34A Methyl {8-fluoro-2-[4-(3-fluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl) acetate (Formula Removed) 100 mg (0.25 mmol) of methyl (2E)-3-{3-fluoro-2-[({[2-methoxy-5-(trifluoromethyl)phenyl]-imino}methylene)amino]phenyl}-2-propenoate (Example ISA), 45.7 mg (0.25 mmol) of l-(3-fluorophenyl)pipera2ine (Example 15A) and a spatula tip of silica gel are stirred in 15ml of dichloromethane at room temperature for 1 hour and then under reflux for 20 hours. The target compound is obtained after chromatography on silica gel (dichloromethane, dichloromethane/ethyl acetate 10:1). Yield: 139.2 mg (96% of theory) HPLC (Method 1): Rt= 4.8 min MS (ESI-pos): m/z = 575 (M)+ Example 35A Methyl {8-fiuoro-2-[4-(3-chlorophenyl)-l-piperazinyl]-3-[3-(rrifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) with 93 mg (0.2 mmol) of the iminophosphorane from Example 10A, the general procedure [G] gives 51 mg (45% of theory) of product. LC-MS (Method 3): R, = 4.78 min MS (ESI-pos): m/z = 561 (M+H)+ Example 36A Methyl {8-fluoro-2-[4-( 1,3 -benzodioxol-5 -yl)-1 -piperazinyl] -3-[3 -(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) Starting with 4.19 g (9.2 mmol) of the iminophosphorane from Example 10A, the general procedure [G] gives 3.67 g (70% of theory) of product. HPLC (Method 1): R, = 4.67 min MS (ESI-pos): m/z = 571 (M+H)+ Example 37A Methyl 4-amino-3 -[(1 E)-3 -tert-butoxy-3-oxoprop-1 -en-1 -yljbenzoate (Formula Removed) Starting with 25.0 g (90.2 mmol) of methyl 4-amino-3-iodobenzoate, the general procedure [A] gives 24.3 g (88% of theory) of product. HPLC (Method 1): R,= 4.71 min MS (DCI-pos): m/z = 295 (M+NHL,)* Example 38 A Methyl (2E)-3-(4-cyano-2-nitrophenyl)-2-propenoate (Formula Removed) Starting with 3.00 g (17.0 mmol) of 4-cyano-2-nitrobenzaldehyde, the general procedure [B] and recrystallization from methanol gives 2.51 g (63% of theory) of product. HPLC (Method 1): Rt= 4.06 min MS (ESI-pos): m/z - 233 (M+H)+ Example 39A Methyl 3 -[2-amino-7-cyanophenyl]propenoate (Formula Removed) Starting with 1.0 g (4.31 mmol) of the nitro compound from Example 3 8A, the general procedure [D] (but without boiling over activated carbon) gives 793 mg (89% of theory) of product. HPLC (Method 1): Rt= 3.99 min Example 40A Methyl (2E)-3-{6-cyano-2-[(triphenylphosphoranylidene)aminolphenyl}propenoate (Formula Removed) Starting with 0.75 g (3.71 mmol) of the amine compound from Example 39A, the general procedure [E] gives 1.09 g (62% of theory) of product. HPLC (Method 1): R, = 4.30 min MS (ESI-pos): m/z = 463 (M+H)+ Example 41A Methyl 3-[(lE)-3-tert-butoxy-3-oxoprop-l-en-l-yl]-4-[(triphenylphosphoranylidene)amino]- benzoate (Formula Removed) Starting with 19.0 g (68.5 mmol) of the amine compound from Example 37A, the general procedure [E] gives 31.4 g (85% of theory) of product. HPLC (Method 1): R. = 4.69 min MS (ESI-pos): m/z = 538 (M+H)+ TCxample 42A Methyl (8-fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluofomethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) This compound is obtained as enantiomer A by separating the racemate from Example 30A chromatographically according to Method 15 in to the enantiomers. Starting with 231 g of racemate, 120 g of the target product, which is directly reacted further, are obtained. MS (ESI-pos): m/z = 575 (M+H)+ Example 43A Methyl {8-fluoro-2-[4-(3-methoxyphenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)- phenyl]- The compound is obtained as enantiomer A by separating the racemate from Example 31A 3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) chromatographically according to Method 15 into the enantiomers. Starting with 231 g of racemate, 111 g (48% of theory) of the target product are obtained. MS (ESI-pos): m/z = 587 (M+H)+ Example 44A Methyl {6-cyano-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) Starting with 400 mg (0.6 mmol) of the iminophosphorane from Example 12A, the general procedure [G] gives 166 mg (48% of theory) of product. HPLC (Method 1): R, = 4.65 min MS (ESI-pos): m/z = 552 (M+H)+ Example 45A Methyl {7-cyano-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) Starting with 1.0 g (2.16 mmol) of the iminophosphorane from Example 40A, the general procedure [G] gives 1.07 g (98% of theory) of product. HPLC (Method 1): Rt = 4.72 min MS (ESI-pos): m/z - 552 (M+H)+ Example 46A Methyl 4-(2-tert-butoxy-2-oxoethyl)-2-[4-(4-fluorophenyl)piperazin-l-yl]-3-[3-(trifluoromethyl)-phenyl]-3,4-dihydroquinazoline-6-carboxylate (Formula Removed) Starting with 4.2 g (9.3 mmol) of the iminophosphorane from Example 41 A, the general procedure [G] gives 3.9 g (51% of theory) of product. HPLC (Method 1): R, = 5.03 min MS (ESI-pos): m/z = 627 (M+H)+ Example 47A Methyl {8-fluoro-2-[4-(4-fluorophenyl)-l-piperazmyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetate (Formula Removed) This compound is obtained as enantidmer A following the separation of enantiomers of 3.5 g of Example 46A (1.4 mg, 20% of theory). HPLC (Method 1): Rt = 4.91 min MS (ESI-pos): m/z= 627 (M+H)+ Example 48A 4-(2-tert-Butoxy-2-oxoethyl)-2-[4-(4-fluorophenyl)piperazin-l-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-6-carboxylic acid (Formula Removed) 3 g (2.0 mmol) of the methyl carboxylate from Example 47A are dissolved in 12 ml of dioxane, 2.4 ml of an aqueous IN solution of potassium hydroxide are added and the mixture is stirred at 60°C for 5 hours. The pH is adjusted to pH=4 using an aqueous IN solution of hydrochloric acid and the reaction mixture is concentrated and purified by preparative HPLC. This gives 580 mg (48% of theory) of the product. HPLC (Method 1): R, = 4.85 min MS (ESl-pos): m/z = 613 (M+H)+ Example 49 A Tert-butyl {6-(aminocarbonyl)-2-[4-(4-fluorophenyl)piperazin-l-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl} acetate (Formula Removed) 560 mg (0.9 mmol) of the carboxylic acid from Example 48A, 2.6 mmol of aluminium chloride, 1.1 mmol of l~hydroxy-lH-benzotriazole hydrate and 1.1 mmol of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide are suspended in DMF. 2.6 mmol of N,N-diisopropylarmne are added, and the mixture is stirred at room temperature for 16 hours. 20 ml of ethyl acetate are added to the reaction mixture, which is then washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution. The combined aqueous phases are adjusted to pH=8 and extracted with ethyl acetate. The combined organic phases are finally washed with a saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated. This gives 548 mg (97% of theory) of product. HPLC (Method 1): Rt = 4.73 min MS (ESI-pos): m/z = 612 (M+H)* Examples 50A to 112A of Table 1 can be prepared from the corresponding starring materials using the general procedures [A] to [G]. Table 1 (Table Removed) Working examples General procedure [HI: Hydrolysis of the quinazolylacetic acid esters 1.0 equivalent of the quinazolyl ester are dissolved in dioxane, and 5.0 equivalents of IN aqueous sodium hydroxide solution are added. The mixture is stirred at 80°C for 16 hours, and after the reaction has ended (the reaction is monitored by analytical HPLC) the mixture is concentrated. The residue is then taken up in water and adjusted to pH 5 using IN hydrochloric acid. The resulting precipitate is filtered off, washed with a little water and diethyl ether and dried at room temperature under high vacuum. Alternatively, the precipitate can be filtered off through an Extrelute cartridge, then washed with ethyl acetate, followed by concentration of the filtrate. If the purity of the product is not high enough, the product is purified either by preparative HPLC on an RP phase (Method 2 or Method 5) or on silica gel using mixtures of cyclohexane/ethyl acetate. Example 1 { 8-Fluoro-2-[4-(4-fluorophenyl)-1 -piperazinyl] -3 -[3 -(trifluoromethy l)phenyl]-3,4-dfhydro-4-quinazolinyl} acetic acid (Formula Removed) Starting with 37 mg (0.07 mmol) of the methyl ester from Example 19A, the general procedure [H] gives 29 mg (80% of theory) of product. HPLC (Method 1): R,= 4.49 min MS (ESI-pos): m/z = 530.7 (M+H)+ 'HNMR (400MHz, CD3CN): 6 [ppm] = 7,5-9 (s, 1H); 7.45 (t, 1H); 7.37 (t, 2H); 7.02-6.95 (m, 3H); .6.93-6.85 (m, 4H); 5.24 (dd, 1H); 2.98 (db, 4H); 2.91 (db, 4H); 2.73 (dd, 1H); 2.54 (dd, 1H). Example 2 {8-Fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) Starting with 695 mg (1.27 mmol) of the methyl ester from Example 20A, the general procedure [H] gives 488 mg (64% of theory) of product. HPLC (Method 1): R,= 4.59 min MS (ESI-pos): m/z = 530.8 (M+H)+ 'H NMR (400 MHz, CD3CN): 5 [ppm] = 7.60 (s, IH); 7.47-7.40 (m, 3H); 7.03-6.86 (m, 7H); 5.26-5.23 (m, IH); 3.60-3.52 (m, 4H); 2.99-2.90 (m, 4H); 2.75 (dd, IH); 2.56 (dd, IH). Example 3 Starting with 34 mg (0.06 mmol) of the methyl ester from Example 23 A, the general procedure [H] {8-Fluoro-2-[4-(3-methylphenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4- quinazolinyl} acetic acid ' (Formula Removed) /sjves 30 mg (90% of theory) of product. HPLC (Method 1): Rt= 4.56 min MS (ESI-pos): m/z = 526.9 (M+H)+ 'H NMR (200 MHz, DMSO-d6): 5 [ppm] = 7.64 (s, 1H); 7.53 (t, 1H); 7.44-7.34 (m, 2H); 7.11-6.90 (m, 3H); 6.72-6.59 (m, 4H); 5.33-5.25 (m, 1H); 3.52 (db, 4H); 3.02 (db, 4H); 2.69-2.55 (m, 2H, partially obscured by DMSO signal); 2.23 (s, 3H). Example 4 {8-Fluoro-2-[4-(3 -methoxyphenyl)-1 -piperazinyl] -3 -[3 -(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) Starting with 36 mg (0.07 mmol) of the methyl ester from Example 25A, the general procedure [H] and chromatography (Method 2) give 28 mg (77% of theory) of product. HPLC (Method l):Rt= 4.46 min MS (ESI-pos): m/z = 542.9 (M+H)+ 'H NMR (200 MHz, DMSO-d6): 5 [ppm] = 7.67 (s, 1H); 7.54 (t, 1H); 7.45-7.38 (m, 2H); 7.14-6.94 (m, 3H); 6.51-6.35 (m, 4H); 5.35-5.25 (m, 1H); 3.69 (s, 3H); 3.50 (db, 4H); 3.06 (db, 4H); 2.58-2.52 (m,2H). Example 5 {8-Fluoro-2-[4-(3-chlorophenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) Starting with 38 mg (0.07 mmol) of the methyl ester from Example 35A, the general procedure [H] gives 25 mg (66% of theory) of product. HPLC (Method 1): Rt= 4.64 min MS (ESI-pos): m/z = 546.9 (M+H)* 'HNMR (200 MHz, DMSO-d6): 8 [ppm] = 7.66 (s, 1H); 7.52 (t, 1H); 7.38 (dd, 2H); 7.20 (t, 1H); 7.10-6.78 (m, 6H); 5.33-5.26 (m, 1H); 3.51 (db, 4H); 3.11 (db, 4H); 2.61-2.55 (m, 2H). Example 6 {8-Fluoro-2-[4-(l,3-benzodioxol-5-yl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl}acetic acid (Formula Removed) Starting with 173 mg (0.30 mmol) of the methyl ester from Example 36A, the general procedure [H] gives 79 mg (46% of theory) of product, HPLC (Method 1): Rt= 4.44 min MS (ESI-pos): m/z = 557.2 (M+H) 'H NMR (300 MHz, CDC13): 5 [ppm] = 7.47 (s, 1H); 7.42-7.34 (m, 3H); 7.03-6.89 (m, 2H); 6.79 f(d, 1H); 6.64 (d, 1H); 6.41 (d, 1H); 6.22 (dd, 1H); 5.87 (s, 2H); 5.20-5.15 (m, 1H); 3.59 (sb, 3H); 2.94-2.85 (m, 5H); 2.59 (dd, 1H). Example 7 {6-Fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[3-(trifIuoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) Starting with 42 mg (0.08 mmol) of the methyl ester from Example 21A, the general procedure [H] gives 34 mg (76% of theory) of product. HPLC (Method 1): Rt= 4.63 min MS (ESI-pos): m/z = 530.9 (M+H)+ Example 8 {6-Fluoro-2-[4-(4-fluorophenyl)-1 -piperazinyl]-3 -[3 -(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid hydrochloride (Formula Removed) Starting with 350 mg (0.64 ramol) of the ester from Example 22A, the general procedure [H] gives 284 mg (83% of theory) of product. HPLC (Method 1): R,= 4.53 min MS (ESI-pos): m/z = 530.8 (M+H-HC1)+ 'H NMR (400 MHz, CD3GN): 8 [ppm] = 7.62 (s, 1H); 7.51-7.48 (m, 1H); 7.43-7.41 (d, 1H); 7.26-7.23 (m, 1H); 7.04-6.95 (m, 2H); 6.91-6.85 (m, 3H); 5.23 (dd, 1H); 3.55 (sb, 3H); 3.02-2.99 (m, 1H); 2.94 (sb, 4H); 2.80 (dd, 1H). Example 9 {8-Fluoro-2r[4-(3-methylphenyl)-l-piperazinyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl) acetic acid hydrochloride (Formula Removed) Starting with 1.10 g (1.93 mmol) of the ester from Example 24A, the general procedlire [H] gives 1.04 g (91% of theory) of product. Following the separation of enantiomers by Method 4, the product is obtained as enantiomer A. ,* HPLC (Method 1): R,= 4.68 min MS (ESI-pos): m/z = 526.9 (M+H-HC1)+ 'H NMR (400 MHz, CD3CN): 5 [ppm] = 7.61 (s, 1H); 7.49-7.38 (m, 3H); 7.10-6.89 (m, 4H); 6.71-6.65 (m, 3H); 5.26 (dd, 1H); 3.60-3.52 (m, 4H); 3.03-2.95 (m, 4H); 2.76 (dd, 1H); 2.57 (dd, 1H); 2.25 (s,3H). Example 10 {8-Fluoro-2-[4-(3-methoxyphenyl)-l-piperazmyl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydro-4- acetic acid hydrochloride (Formula Removed) Starting with 437 mg (0.79 mmol) of the ester from Example 26A, the general procedure [H] gives 344 mg (72% of theory) of product. HPLC (Method 1): Rt= 4.48 min MS (ESI-pos): m/z = 543.0 (M+H-HC1)+ 'H NMR (400 MHz, CD3CN): 8 [ppm] = 7.61 (s, IH); 7.49-7.38 (m, 3H); 7.14-6.89 (m, 4H); 6.47-6.39 (m, 3H); 5.26 (dd, IH); 3.72 (s, IH); 3.60-3.54 (m, 4H); 3.07-3.00 (m, 4H); 2.77 (dd, IH); 2.57 (dd, IH). Example 11 {8-Fluoro-2-[4-(4-fluoro-3 -methylphenyl)-1 -piperazinyl] -3 -[6-methoxy-3 -(trifluoromethyl)-phenyl]-3,4-dihydro-4-quinazolinyl}acetic acid hydrochloride (Formula Removed) Starting with 1.03 g (1.75 mmol) of the crude product of the ester from Example 27A, the general procedure [H] and chromatography according to Method 5 followed by dissolution of the product methanol/lN hydrochloric acid and re-evaporation of the solvent give 283 mg (22% of theory) ofhydrochloride. HPLC (Method 1); Rt= 4.58 min MS (ESI-pos): m/z = 575.2 (M+H-HC1)* 'H NMR (400 MHz, CD3CN): 5 [ppm] = 8.17 (s, 0.66H); 7.69 (d, 1H); 7.55-7.30 (m, 1H); 7.27-7,24 (m, 2H); 7.16 (d, 0.6H); 7.09-7.04 (m, 2H); 5.33-5.27, 5.12-5.06 (2x m, 1H); 4.08-3.35 (m, 4H); 3.69 (s, 3H); 3.30-3.22 (m, 1H); 2.80-2.76 (m, 1H); 2.25 (s, 3H). Example 12 {8-Fluoro-2-[4-(4-fluoro-3-methylphenyl)-l-piperazinyl]-3-[6-methoxy-3-(trifluoromethyl)-phenyl]-3,4-dihydro-4-quinazolinyl}acetic acid hydrochloride (Formula Removed) Prior to the separation of enantiomers, 268 mg of the hydrochloride from Example 11 are taken up in dichloromethane, and the organic phase is extracted twice with saturated sodium bicarbonate solution. The combined aqueous phases are extracted once with dichloromethane, the combined organic phases are dried over sodium sulphate and filtered and the solvent is removed under reduced pressure. This gives 204 mg (86% of theory) of the free base. Using this material, separation of enantiomers (Method 4), re-purification by preparative HPLC (Method 5) and subsequent dissolution of the product in methanol/lN hydrochloric acid and re-evaporation of the solvent gives 80 mg (78% of theory) of enantiomer A. HPLC (Method 6): R,= 4.66 min MS (ESI-pos): m/z = 575.2 (M+H-HC1)+ 'H NMR (400 MHz, CD3CN): 5 [ppm] = 8.17 (s, 0.66H); 7.69 (d, 1H); 7.45-7.30 (m, 1H); 7.24 (d, H); 7.15 (d, 0.7H); 7.08-7.01 (m, 2H); 5.32-5.27, 5.11-5.07 (2x m, 1H); 4.06-3.50 (m, 4H); 3.68 (s, 3H); 3.33-3.24 (m, 1H); 2.77-2.72 (m, 1H); 2.24,2.23 (2x s, 3H). Example 13 {8-Fluoro-2-[4-(4-fluoro-3-methylphenyl)-l-piperazinyl]-3-[6-methoxy-3-methylphenyl]-3,4-dihydro-4-quinazolinyl} acetic acid hydrochloride (Formula Removed) Starting with 183 mg (0.34 mmol) of the crude product of the ester from Example 28 A, the general procedure [H] and chromatography according to Method 5 followed by dissolution of the product in methanol/lN hydrochloric acid and re-evaporation of the solvent give 135 mg (67% of theory) of hydrochloride. HPLC (Method 1): R,= 4.67 min MS (ESI-pos): m/z = 521.2 (M+H-HC1)+ 'HNMR (400 MHz, CD3CN): 5 [ppm] = 7.69-7.42 (m, 4H); 7.25-7.06 (m, 5H); 6.93-6.78 (m, 1H); 5.24-5.21, 5.06-5.03 (2x m, 1H); 4.00-3.35 (m, 8H); 3.21-3.08 (m,"lH); 3.01-2.77 (m, 1H); 2.34, 2.20 (2x s, 3H); 2.26 (s, 3H). Example 14 {8 -Fluoro-2 -[4-(3 -methoxyphenyl)-1 -piperazinyl] -3 - [2-methoxy-5 -(trifluoromethyl)phenyl] -3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) At room temperature, 179.6 mg (4.49 mmol) of sodium hydroxide are added to 878 mg (1.5 mmol) of methyl {8-fluoro-2-[4-(3-methoxyphenyl)-l-piperazinyl]-3-[2-methoxy-5- (trifluoromethy^pheny1]-3,4-dihydro-4-quinazolinylJacetate (Example 31 A) in 40ml of dioxane, and the mixture is stirred at 50°C for 2 hours. The pH is then adjusted to 4-5. The product is filtered off, washed with water and dried under reduced pressure. Yield: 801 mg (93% of theory) HPLC (Method 1): R,= 4.5 min MS (ESI-pos): m/z = 573 (M+H)+ Example 15 {8-Fluoro-2-[4-(3-methoxyphenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4- dihydro-4-quinazolinyl} acetic acid (Formula Removed) After separation of enantiomers (Method 11) of 500 mg of racemate (Example 14), the crude product is purified by chromatography on silica gel and then dissolved in IN aqueous sodium hydroxide solution and extracted with diethyl ether. Following acidification with IN hydrochloric acid, the product is filtered off and dried under reduced pressure. Yield: 105 mg (21% of theory) MS (ESI-pos): m/z = 573 (M+H)+ 'H NMR (300 MHz, DMSO-d6): 5 [ppm] = 2.4-2.5 (m, 1H); 2.7-3.1 (m, 5H); 3.3-3.6 (m, 4H); 3.7 (s, 3H); 3.7-3.9 (sb, 3H); 4.8-5.05 (sb, 1H); 6.3-6.4 (m, 2H); 6.4-6.5 (m, 1H); 6.8-7.65 (m, 6H); 12.5 (Sb, 1H). Alternatively, the target product is obtained by reacting the enantiomerically pure ester from Example 43 A according to the general procedure [H]. Starting with 111 g (0.19 mol) of ester, 69 g (63% of theory) of target product are obtained. Example 16 {8-Fluoro-2-[4-(3,4-difluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) In 40 ml of dioxane, 881 mg (1.49 mmol) of methyl {8-fluoro-2-[4-(3,4-difluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl}acetate (Example 32A) and 178 mg (4.46 mmol) of sodium hydroxide are stirred at 50°C for 2 hours. Following acidification with IN hydrochloric acid, the product is filtered off with suction, washed with water and dried under reduced pressure. Yield: 775 mg (90% of theory) HPLC (Method 1): Rt= 4.5 min MS (ESI-pos): m/z = 579 (M+H)f {8-Fluoro-2-[4-(3,4-difluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) Following the separation of enantiomers (Method 12) of 500 mg (0.86 mmol) of racemate (Example 16), the crude product is purified by chromatography on silica gel (dichloromethane, dichloromethane/methanol 20:1, 10:1), dissolved in IN aqueous sodium hydroxide solution and extracted with diethyl ether. Using IN hydrochloric acid the aqueous phase is adjusted to pH 4-5, and the product is filtered off, washed with water and dried under reduced pressure. Yield: 86 mg (17% of theory) MS (ESI-pos): m/z = 579 (M+H)+ 'HNMR (300 MHz, DMSO-ds): 5 [ppm] = 2.6-3.1 (m, 6H); 3.25-3.6 (m, 4H); 3.75 (sb, 3H); 4.85 (sb, 1H); 6.6-6.7 (m, 1H); 6.7-7.7 (m, 9H); 12.5 (sb, 1H). Example 18 {8-Fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) In 800 ml of dioxane, 15 g (26.11 mmol) of methyl {8-fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phehyl]-3,4-dihydro-4-quinazolinyl}acetate (Example 30A) and 3.13 g (78.32 mmol) of sodium hydroxide are stirred at 50°C for 4 hours. Following distillative removal of the solvent, the residue is dissolved in 500 ml of water and acidified and the precipitate is filtered off with suction. The product is washed with water and dried under reduced pressure. Yield: 14.5 g (99% of theory) HPLC (Method 1): R,= 4.5 min MS (ESI-pos): m/z = 561 (M+H)+ Example 19 {8-Fluoro-2-[4-(4-fluorophenyl)-1 -piperazinyl]-3 -[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) 14.2 g (25.33 mmol) of racemate (Example 18) .are separated (Method 13). The crude product is dissolved in 250 ml of 0.5N sodium hydroxide solution and then purified by extraction with diethyl ether. After acidification of the aqueous phase with hydrochloric acid, the product is off, washed with water and dried under reduced pressure. Yield: 5.85 g (4.1% of theory) MS (ESI-pos): m/z = 561 (M+H)+ HPLC (Method 1): Rt= 4.5 min 'HNMR (400 MHz, DMSO-d6): 5 [ppm] = 2.6-3.0 (m, 6H); 3.3-3.6 (m, 4H); 3.6-4.0 (sb, 3H); 4.8-5.2 (sb, 1H); 6.7-7.75 (m, 10H); 12.2-12.8 (sb, 1H). Alternatively, the target product is obtained by reacting the enantiomerically pure ester from Example 42A according to the general procedure [H]. Starting with 120 g (0.21 mol) of ester, 96 g (81% of theory) of target product are obtained. Example 20 {8-Fluoro-2-[4-(3-methylphenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} ac etic acid (Formula Removed) In 40 ml of dioxane, 892 mg (1.56 mmol) of methyl {8-fluoro-2-[4-(3-methylphenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluorornethyl)phenyl]-3,4-dihydro-4-quinazolinyl}acetate (Example 33 A) and 187.6 mg (4.69 mmol) of sodium hydroxide are stirred at 50°C for 2 hours. Following removal of the solvent, the residue is taken up in water and adjusted to pH 4-5 using IN hydrochloric acid. The product is filtered off and then washed with water and dried under reduced pressure. Yield: 788 mg (91% of theory) MS (ESI-pos): m/z = 557 (M+H)+ HPLC (Method 6): Rt= 4.5 min Example 21 {8-Fluoro-2-[4-(3-methylphenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) The separation of enantiomers (Method 13) is carried out using 500 mg (0.9 mmol) of racemate (Example 20). The crude product is then dissolved in IN aqueous sodium hydroxide solution, the solution is extracted with diethyl ether and the aqueous phase is adjusted to pH 4-5 using IN hydrochloric acid. The product is filtered off with suction, washed with water and dried under reduced pressure. Yield: 104 mg (21% of theory) MS (ESI-pos): m/z = 557 (M+H)+ 'HNMR (400 MHz, DMSO-dg): 5 [ppm] = 2.2 (sb) 3 H); 2.35-2.5 (m, 1H); 2.6-3.1 (m, 5 H); 3.3-3.6 (m, 4 H);-3-:8 (sb, 3 H); 4.9 (sb, 1H); 6.5-6.7 (m, 3 H); 6.8-7.7 (my 7H); 12.6 (sb, 1H). Example 22 {8-Fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[6-methoxy-3-chlorophenyl]-3,4-dihydro-4-quinazolinyl} acetic acid hydrochloride (Formula Removed) Starting with 621 mg (1.15 mmol) of the ester from Example 29A, the general procedure [H] and purification by preparative HPLC (Method 5) and coevaporation with methanol/lN hydrochloric acid give 3 3 6 mg (51 % of theory) of product. HPLC (Method 1): R,= 4.58 min MS (ESI-pos): m/z = 527.0 (M+H-HC1)+ Example 23 {8-Fluoro-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[6-methoxy-3-chlorophenyl]-3,4-dihydro-4-quinazolinyl} acetic acid hydrochloride (Formula Removed) Starting with 320 mg (0.06 mmol) of the racemate from Example 22, chromatographic separation of enantiomers (Method 4) and subsequent dissolution of the product in methanol/lN hydrochloric acid and re-evaporation of the solvent give 174 mg (50% of theory) of hydrochloride. HPLC (Method 1): Rt= 4.51 min MS (ESI-pos): m/z = 527.1 (M+H-HC1)+ HNMR (400MHz, CD3CN): 6 [ppm] = 7.29 (dd, 1H); 7.19-7.11 (m, 2H); 7.01-6.94 (m, 4H); 6.87-6.83 (m, 2H); 5.08 (t, 1H); 3.67 (s, 3H); 3.56 (s, 4H); 3.03-2.92 (m, 5H); 2.72 (dd, 1H). Example 24 {8-Fluoro-2-[4-(3-fluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quiriazolinyl} acetic acid (Formula Removed) In 15 ml of dioxane, 117 mg (0.2 mrnol) of methyl {8-fluoro-2-[4-(3-fluorophenyl)-l-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl}acetate (Example 34A) are mixed with 0.61 ml of IN aqueous sodium hydroxide solution, and the mixture is stirred at 50°C for 3 hours. After removal of the solvent, the residue is taken up in water and the mixture is adjusted to pH 3-4 using IN hydrochloric acid. The precipitate is filtered off with suction, washed with water and dried under reduced pressure. Yield: 76 mg (67% of theory) HPLC (Method 1): R,= 4.6 min MS (ESI-pos): m/z = 561 (M+H)+ Example 25 {8-Fluoro-2-[4-(3-fluorophenyl)-l-piperazmyl]-3-[2-methoxy-5-(triflupromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) 52 mg (0.09 mmol) of the raceinate (Example 24) are separated into the enantiomers (Method 13). The crude product is then purified by chromatography on silica gel (acetic acid, dichloromethane/methanol 10:1) and dried under reduced pressure. Yield: 12.3 mg (24% of theory) LC-MS (Method 7): Rp 2.50 min MS (ESI-pos): m/z = 561 (M+H)+ JH NMR (400 MHz, DMSO-d*): 5 [ppm] = 2.35-2.5 (m, IH); 2.7-3.1 (m, 5H); 3.3-3.6 (m, 4H); 3.8 (sb) 3H); 4.8-4.9 (m, IH); 6.45-6.6 (m, IH); 6.6-6.7 (m, 2H); 6.8-6.9 (m, 2H); 6.98-7.1 (m, IH); 7.1-7.6 (m, 4H); 12.4 (sb, IH). Examples 26 to 34 and 36 to 89 of Table 2 can be prepared from the corresponding starting materials using the general procedures [A] to [H], and Example 35 can be prepared as described below in Table 2. (Table Removed) Table 2 Example 25 (2-[4-(4-Fluorophenyl)piperazin-1 -yl]-8-hydroxy-3 -[3 -(trifluoromethyl)phenyl] -3,4-dihydroquinazolin-4-yl) acetic acid (Formula Removed) 80 mg (0.14 mmol) of the methyl ether (Example 89) are dissolved in 2 ml of dichloromethane, and 0.41 mmol of a 1M solution of boron tribromide in dichloromethane is added at 0°C. The mixture is stirred at room temperature for 16 hours, a further 0.82 mmol of the boron tribromide solution is added, followed by a further 1.23 mmol after 24 hours. The reaction mixture is stirred at room temperature for 24 hours and then poured onto ice, and 5 ml of a IN aqueous hydrochloric acid solution are added. The mixture is extracted with 25 ml of ethyl acetate. The organic phase is washed with a saturated aqueous sodium chloride solution, dried over sodium sulphate, concentrated and purified by preparative HPLC. This gives 50 mg (63% of theory) of product. HPLC (Method 1): Rt= 4.47 min MS (ESI-pos):.m/z = 529 (M+H-HC1)+ Example 90 {7^Hydroxycarbonyl-2-[4-(4-fluorophenyl)-l-piperazinyl]-3-[5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl} acetic acid (Formula Removed) 100 mg (0.16 mmol) of the ester from Example 45A are suspended in semiconcentrated hydrochloric acid, and the reaction mixture is stirred at 90°C for 42 hours. After cooling, the mixture is adjusted to pH=4 using 20% strength aqueous sodium hydroxide solution and the precipitate that is formed is filtered off, washed with water and dried under reduced pressure. Yield: 64 mg (66% of theory) HPLC (Method 1): Rt= 4.38 min MS (ESI-pos): m/z = 557 (M+H)+ Example 91 {6-(Aminocarbonyl)-2-[4-(4-fluorophenyl)piperazin-l-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl} acetic acid hydrochloride 500 mg (0.8 mmol) of the tert-butyl ester from Example 49A are suspended with 8 ml of a 4M solution of hydrogen chloride in dioxane, and the reaction mixture is stirred at room temperature for 16 hours. The suspension is concentrated and dried under reduced pressure. (Formula Removed) pfield: 564 mg (99% of theory) HPLC (Method 1): Rt= 4.25 min MS (ESI-pos): m/z = 556 (M+H-HC1)+ 'H NMR (300 MHz, DMSO-d6): 6 [ppm] = 12.94 (brs, 1H); 8.11 (s, 1H); 8.03-7.95 (m, 2H); 7.92-7.65 (m, 4H); 7.09-6.91 (m, 4H); 5.50 (dd, 1H); 4.38-4.12 (m, 4H); 3.17-3.06 (m, 5H); 2.81 (dd, IH). B*. Assessment of the physiological activity The in vitro effect of the compounds of the invention can be shown in the following assays: Anti-HCMV (anti-human cytomegalovirus) cytopathogenicity tests The test compounds are employed as 50 millimolar (mM) solutions in dimethyl sulphoxide (DMSO). Ganciclovir®, Foscarnet® and Cidofovir® are used as reference compounds. After addition of in each case 2 µl of the 50, 5, 0.5 and 0.05 mM DMSO stock solutions to 98 µl portions of cell culture medium in row 2 A-H for duplicate determinations, 1 :2 dilutions are carried out with 50µl portions of medium up to row 11 of the 96-well plate. The wells in rows 1 and 12 each contain 50 µl of medium. In 150 µl of a suspension of 1 x 104 cells (human prepuce fibroblasts [NHDF]) are pipetted into each of the wells (row 1 = cell control) and, in rows 2-12, a mixture of HCMV-infected and uninfected NHDF cells (M.O.I = 0.001 - 0.002), i.e. 1-2 infected cells per 1000 uninfected cells. Row 12 (without substance) serves as virus control. The final test concentrations are 250-0.0005 µM. The plates are incubated at 37°C/5% CO2 for 6 days, i.e. until all the cells are infected in the virus controls (100% cytopathogenic effect [CPE]). The wells are then fixed and stained by adding a mixture of formalin and Giemsa's dye (30 minutes), washed with double-distilled water and dried in a drying oven at 50°C. The plates are then assessed visually using an overhead microscope (Plaque Multiplier from Technomara). The following data can be acquired from the test plates: (NHDF) = substance concentration in µM at which no visible cytostatic effects on the cells are evident by comparison with the untreated cell control;* EC50 (HCMV) = substance concentration in µM which inhibits the CPE (cytopathic effect) by 50% compared with the untreated virus control; SI (selectivity index) = CC50 (NHDF) / EC50 (HCMV). Representative in vitro data for the effects of the compounds of the invention are shown in Table A: Table A (Table Removed) The suitability of the compounds of the invention for the treatment of HCMV infections can be shown in the following animal model: HCMV Xenograft Gelfoam® model Animals: 3-4-week old female immunodeficient mice (16-18 g), Fox Chase SCID or Fox Chase SCID-NOD or SCID beige, are purchased from commercial breeders (Taconic M+B, Jackson USA). The animals are housed under sterile conditions (including bedding and feed) in isolators. Virus growing: " Human cytomegalovirus (HCMV), Davis or AD 169 strain, is grown in vitro on human embryonic prepuce fibroblasts (NHDF cells). After the NHDF cells have been infected with a multiplicity of infection (M.O.I.) of 0.01-0.03, the virus-infected cells are harvested 5-10 days later and stored in the presence of minimal essential medium (MEM), 10% fetal calf serum (PCS) with 10% DMSO at -40°C. After serial ten-fold dilutions of the virus- .infected cells, the titer is determined on 24-well plates of confluent NHDF cells after vital staining with Neutral Red. Preparation of the sponges, transplantation, treatment and evaluation: Collagen sponges 1xlxl cm in size (Gelfoam®; from Peasel & Lorey, order No. 407534; K.T. Chong et al., Abstracts of 39th 1nterscience Conference on Antimicrobial Agents and Chemotherapy, 1999, p. 439) are initially wetted with phosphate-buffered saline (PBS), the trapped air bubbles are removed by degassing, and then stored in MEM + 10% PCS. lx 106 virus-infected NHDF cells (infection with HCMV Davis or HCMV AD 169 M.O.I. = 0.01) are detached 3 hours after infection and added in a drop of 20 µl of MEM, 10% of PCS, to a moist sponge. About 16 hours later, the infected sponges are incubated with 25 µ1 of PBS / 0.1% BSA / 1 mM DTT with 5 ng/µl basic fibroblast growth factor (bFGF). For the transplantation, the immunodeficient mice are anaesthetized with Avertin or a ketamine/xylazine/azepromazine mixture, the fur on the back is removed using a shaver, the epidermis is opened 1-2 cm, unstressed and the moist sponges are transplanted under the dorsal skin. The surgical wound is closed with tissue glue. 6 hours after the transplantation, the mice can be treated for the first time (on the day of the operation, there is one treatment). The next days, over a period of 8 days, the mice are treated with substance orally three times a day (7.00 h and 14.00 h and 19.00 h), two times a day (8.00 h and 18.00 h) or once a day (14.00 h). The daily dose is, for example 3 or 10 or 30 or 60 or lOOmg/kg of body weight, the volume administered is 10 ml/kg of body weight. The substances are formulated in the form of a 0.5% strength Tylose suspension with 2% DMSO or a 0.5% strength Tylose suspension. 9 days after transplantation and 16 hours after the last administration of substance, the animals are painlessly sacrificed and the sponge is removed. The virus-infected cells are released from the sponge by collagenase digestion (330 U/1.5 ml) and stored in the presence of MEM, 10% fetal calf serum, 10% DMSO at -140°C. Evaluation takes place after serial ten-fold dilutions of the virus-infected cells by determining the titer on 24-well plates of confluent NHDF cells after vital staining with Neutral Red. The number of infected cells or infectious virus particles (infectious centre assay) after the substance treatment compared with the placebo-treated control is determined. CYP inhibition assay To investigate the mechanism-based (irreversible) inhibition of CYP3A4, different concentrations of the test substance are incubated with human liver microsomes (2 mg/ml of microsomal protein) in potassium phosphate buffer pH 7.4 with addition of an NADPH-generating system (NADP+, glucose 6-phosphate, glucose 6-phosphate dehydrogenase) at 37°C. At various points of time, 2 aliquots are taken from the incubation. The first aliquot is incubated 1:50 in a new incubation solution (phosphate buffer, NADPH-generating system and 10 µM of Midazolam) at 37°C for a further l0 min. The incubation is then stopped using acetonitrile on ice, the protein is pelleted in a centrifuge at 15 000 g and the supernatant is analysed for formation of r-hydroxyimidazolam using standard HPLC/MS methods. The second aliquot is stopped using acetonitrile on ice and analysed for remaining test substance using HPLC/UV/MS. The two sets of analytical data are determined for irreversible-inhibition-typical parameters (kmact, KJ and partition ratio r), and using these data, the test substance is evaluated (cf. A. Madan, et al., in A.D. Rodrigues (ed.) "Drug-Drug Interaction" in "Drugs and the Pharmaceutical Science", Vol. 116, ISBN 0-8247-0283.2, Marcel Dekker Inc., New York, 2002.). C. Exemplary embodiments of pharmaceutical compositions The compounds of the invention can be converted into pharmaceutical preparations in the following ways: Tablet: Composition: 100 mg of the compound of Example 1, 50 mg of lactose (monohydrate), 50 mg of corn starch (native), 10 mg of polyvrnylpyrrolidone (PVP 25) (from BASF, Ludwigshafen, Germany) and 2 mg of magnesium stearate. Tablet weight 212 mg. Diameter 8 mm, radius of curvature 12 mm. roduction: The mixture of active ingredient, lactose and starch is granulated: with a 5% strength solution (m/m) of the PVP in water. The granules are then dried and mixed with the magnesium stearate for 5 min. This mixture is compressed using a conventional tablet press (see above for format of the tablet). A guideline for the compressive force used for the compression is 15 kN. Suspension which can be administered orally: Composition: 1000 mg of the compound of Example 1, 1000 mg of ethanol (96%), 400 mg of Rhodigel (xanthan gum from FMC, Pennsylvania, USA) and 99 g of water. 10 ml of oral suspension are equivalent to a single dose of 100 mg of the compound of the invention. Production: The Rhodigel is suspended in ethanol, and the active ingredient is added to the suspension. The water is added while stirring. The mixture is stirred for about 6 h until the swelling of the Rhodigel is complete. Solution which can be administered intravenously: Composition: 10-500 mg of the compound of Example 1, 15 g of polyethylene glycol 400 and 250 g of water for injection. Production: The compound of .Example 1 is dissolved together with polyethylene glycol 400 in the water with stirring. The solution is sterilized by filtration (pore diameter 0.22 /im) and dispensed under aseptic conditions into heat-sterilized infusion bottles. The latter are closed with infusion stoppers and trimmed caps. We Claim: 1. Substituted dihydroquinazoline compounds of the formula (Formula Removed) in which Ar represents aryl which may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of alkyl, ailcoxy, forhyl, carboxyl, alkylcarbonyl, alkoxycarboilyl, trifluoromethyl, halogen, cyano, hydroxl, amino, alkylantino, aminocarbonyl and nitro, where alkyl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of halogen, amino, alkylaniino, hydroxyl and aryl, or two of the substituents on the aryl radical together with the carbon atoms to which they are attached form a 1, 3-dioxolahe, a cyclopentane ring or a cyclohexane ring, and any third substituent present is selected independently from the group mentioned, R1 represents hydrogen, amino, alkyl, alkoxy, alkylamino, alkylthio, cyano, halogen, nitro or trifluoromethyl, R2 represents hydrogen, alkyl, alkoxy, alkylthio, cyano, halogen, nitro or trifluoro- methyl, R3 represents amino, alkyl, alkoxy, alkylamino, alkylthio, cyano, halogen, nitro, trifluoromethyl, alkylsulphonyl or alkylaminosulphonyl or one of the radicals R1, R2 and R3 represents hydrogen, alkyl, alkoxy, cyano, halogen, nitro or trifluoromethyl and the other two together with or the carbon atoms to which they are attached form a 1 ,3-dioxolane, a cyclopentane ring or a cyclohexane ring, R4 represents hydrogen or alkyl, R5 represents hydrogen or alkyl]. or the radicals R4 and R5 are attached to carbon atoms directly opposing each other in the piperazine ring and form a methylene bridge which is optionally substituted by 1 or 2 methyl groups, R6 represents alkyl, alkoxy, alkylthio, formyl, carboxyl, aminocarbonyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hydroxyl or nitro, R7 represents hydrogen, alkyl, alkoxy, alkylthio, formyl, carboxyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hydroxyl or nitro and R8 represents hydrogen, alkyl, alkoxy, alkylthio, formyl, carboxyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hydroxyl or nitro, and their salts, solvates and solvates of the salts 2. A compound as claimed in Claim 1, wherein Ar represents phenyl which, may be substituted b 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of C1-C6-alkyl, C1-C6-alkoxy, carboxyl, C1-C6-alkylcarbonyl, C1-C6-alkoxycarbonyl, trifluoromethyl, fluorine, chlorine, bromine, cyano, hydroxyl, amino, C1-C6-alkylamino and nitro, or two of the substituents on the phenyl radical together with the carbon atoms to which they are attached form a 1,3-dioxolane and any third substituent present is selected independently from the group mentioned, R1 represents hydrogen, C1-C3-alkyl, C14D3-alkoxy, C1-C3-alkylthio, fluorine or chlorine, R2 represents hydrogen, C1-C3-alkyl, C1-C3-alkoxy, C1-C3-alkylthio, fluorine or chlorine, R3 represents C1-C4- alky1, cyano, fluorine, chlarine, nitro, trifluoromethyl or C1-C3-alkylsuiphonyl, One of the radicals R1, R2 and R3 represents hydrogen, C1-C3-.alkyl, C1-C3-alkoxy cyano, halogen,nitro or trifluoromethyl and the other two together with the carbon atoms to which they are attached form a cyclopentane ring or a cyclohexane ring, R4 represents hydrogen or methyl, R5 represents hydrogen, R6 represents C1-C3alkyl, C1-C3-alkoxy, carboxyl, arninocarbonyl, trifluoromethyl, fluorine, chlorine, cyano, hydroxyl or intro, R7 represents hydrogen, C1-C3-alkyl, C1-C3-alkoxy, fluorine, chlorine, cyano or hydroxyl and R8 represents hydrogen, C1-C3-alkyl, C1-C3-alkoxy, fluorine, chlorite, cyano or hydroxyl. 3. A compound claimed in as claim 1 or 2, wherein Ar represents, phenyl which may be substituted by 1, or 2 substituents, where the substituents are selected independently of one another from the group consisting of methyl; methoxy, fluorine and chlorine, R1 represents hydrogen, methyl, methoxy, rnethylthio, fluorine or chlorine, R2 represents-hydrogen, R3 represents methyl, isopropyl, tert-butyl, cyano, fluorine, chlorine, nitro or trifluoromethyl, R4 represents hydrogen, R5 represents hydrogen, R6 represents arninocarbonyl, fluorine, chlorine, cyano or hydroxyl, R7 represents hydrogen and R8 represents hydrogen, fluorine or chlorine. 4. A compound as claimed in any of Claims 1 to 3, wherein R1 represents hydrogen, methyl, methoxy or fluorine. 5. A compound as claimed in any of Claims 1 to 4, wherein R1 represents methoxy. 6. A compound as claimed in any of Claims 1 to 5, wherein R1 is attached to the phenyl ring via the position ortho to the point of attachment of the phenyl ring. 7. A compound as claimed in any of Claims 1, 2 and 4 to 6, wherein R2 represents hydrogen. 8. A compound as claimed in any of Claims 1 to 7, wherein R3 represents trifluoromethyl, chlorine, methyl, isopropyl or tert-butyl. 9. A compound as claimed in any of Claims 1 to 8, wherein R3 represents trifluoromethyl, chlorine or methyl. 10. A compound as claimed in any of Claims 1 to 9 wherein R1 is attached to the phenyl ring via the position ortho to the point of attachment of the phenyl ring and R3 is attached to the phenyl ring via the position mete to the point of attachment of the phenyl ring, which position is opposite to that of R1. 11. A compound as claimed in any of Claims 1, 2 and 4 to 10, wherein R4 and R5 represent hydrogen. in which Ar, R1, R2, R3, R4, R5; R6; R7 and R8 are as defined in Claim 1 12. A compound as claimed in any of Claims 1 to 11, wherein R6 represents fluorine. 13. A compound as claimed in any of Claims 1, 2 and 4 to 12, wherein R7 represents hydrogen. 14. A compound as claimed in claims 1, 2 and 4 to 13, wherein R8 represents hydrogen, methyl or fluorine. 15. A compound as claimed in any of Claims 1, 2 and 4 to 14, wherein Ar represents phenyl which may be substituted by 1 or 2 substituents, where the substituents are selected independently of one another from the group consisting of methyl, methoxy, fluorine and chlorine. 16. A process for preparing a compound of the formula (I) as claimed in Claim 1, wherein a compound of the formula. (Formula Removed) and R9 represents alkyl, preferably methyl or ethyl or tert-butyl, is reacted with a base or an acid. 17. A compound as claimed in to any of claims 1 to 15 for the treatment and/or the prophylaxis of diseases. 18. A medicament comprising a compound as claimed in Claims 1 to 15 in combination with an inert non-toxic pharmaceutically acceptable auxiliary. 19. A medicament as claimed in Claim 18 for the treatment and /or prophylaxis of viral infections.

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4403-DELNP-2005-Abstract-(09-02-2009).pdf

4403-delnp-2005-abstract.pdf

4403-DELNP-2005-Claims-(09-02-2009).pdf

4403-delnp-2005-claims.pdf

4403-DELNP-2005-Correspondence-Others-(09-02-2009).pdf

4403-delnp-2005-correspondence-others.pdf

4403-DELNP-2005-Description (Complete)-(09-02-2009).pdf

4403-delnp-2005-description (complete).pdf

4403-DELNP-2005-Form-1-(09-02-2009).pdf

4403-delnp-2005-form-1.pdf

4403-delnp-2005-form-18.pdf

4403-DELNP-2005-Form-2-(09-02-2009).pdf

4403-delnp-2005-form-2.pdf

4403-DELNP-2005-Form-3-(09-02-2009).pdf

4403-delnp-2005-form-3.pdf

4403-delnp-2005-form-5.pdf

4403-DELNP-2005-GPA-(09-02-2009).pdf

4403-delnp-2005-gpa.pdf

4403-delnp-2005-pct-210.pdf

4403-delnp-2005-pct-304.pdf

4403-DELNP-2005-Petition-137-(09-02-2009).pdf

4403-DELNP-2005-Petition-138-(09-02-2009).pdf