Title of Invention

"METHOD OF PREPARING AMINE STEREOISOMERS"

Abstract

METHOD FOR PREPARING AN AMINE STEREOISOMER The present invention provides a method lor preparing an amine stereoisomer, which comprises: (a) forming a sulfinvlamine stereoisomer by stcreoselcrtively reducing a sulfinyhmine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a suUinyliminc stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine wilh a source of a nucleophile, lollowed by; (b) contacting the sulfinylarninc stereoisomer with a reagent suitable lor the rlea\age of a sulfur nitrogen bond, to afford an amine stereoisomer.

Full Text

This invention relates to a method of preparing amine stereoisomers, to novel intermediates useful in the method and to use of certain of the novel intermediates in a method of preparing sulfoxide and sulfinylamine stereoisomers. Many amine stereoisomers possess useful biological properties. For example, sibutramine is a neuronal monoamine reuptake inhibitor, which has the chemical name [N-l-[l-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-N,N-dimethylamine. Originally disclosed in U.S. Patent Nos. 4,746,680 and 4,806,570, sibutramine inhibits the reuptake of norepinephrine and, to a lesser extent, serotonin and dopamine. See, e.g., Buckett et al, Prog. Neuro-psychopharm. & Biol. Psychiat., 12:575-584, 1988; King et al, J. Clin. Pharm., 26:607-611 (1989). Racemic sibutramine is sold as a hydrochloride monohydrate under the tradename MERIDIA®, and is indicated for the treatment of obesity. Physician's Desk Reference® 1509-1513 (54th ed., 2000). The treatment of obesity using racemic sibutramine is disclosed, for example, in U.S. Patent No. 5,436,272. Sibutramine is rapidly absorbed from the gastrointestinal tract following oral administration and undergoes an extensive first-pass metabolism that yields the metabolites desmethylsibutramme ("DMS") and didesmethylsibutramine ("DDMS"), as shown below in Scheme 1. (Scheme Removed) Both didesmethylsibutramine and desmethylsibutramine have interesting and useful biological properties. Each of these sibutramine metabolites can exist as an enantiomeric pair of R and S enantiomers, as shown below in Scheme n, which also exhibit interesting and useful biological properties: (Scheme Removed) The preparation of enantiomerically pure metabolites of sibutramine and derivatives thereof {e.g., didesmethylsibutramine) has been difficult. Consequently, a need exists for improved methods of synthesis. Several methods of preparing amine stereoisomers are known in the art. One general method comprises asymmetric addition to an imine, such as by reduction (which adds hydrogen atoms to the carbon and nitrogen atoms at the ends of the C=N double bond) or by reaction with a source of a nucleophile (which adds hydrogen to the nitrogen atom and the nucleophile to the carbon atom). For example, when the source of a nucleophile is a source of a nitrile, such as HCN, the reaction affords an amine stereoisomer in which hydrogen is added to the nitrogen atom and CN to the carbon atom. The nitrile group may then be hydrolyzed to afford an alpha-substituted amino acid stereoisomer. One such method that has been reported, for example in Liu et ah, J. Am. Chem. Soc, 1997,119, 9913-9914, comprises addition to a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of a hydrocarbyl group, such as p-toluyl or tert-butyl. The resultant sulfinylimine may then be treated with a reagent suitable for the cleavage of a sulfur-nitrogen bond, such as hydrochloric acid, to afford an amine stereoisomer. The sulfinylimine stereoisomers starting materials may be obtained by reacting a carbonyl compound, such as an aldehyde of ketone, with a sulfinamide stereoisomer, such as a p-toluenesulfinamide or tert-butanesulfinanide stereoisomer. A novel method of preparing amine stereoisomers has now been found that starts with a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine. According to one aspect, therefore, the present invention provides a method of preparing an amine stereoisomer, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, to afford a sulfinylamine stereoisomer, followed by contacting the sulfinylamine stereoisomer with a reagent suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer. It will be appreciated that reduction of the sulfinylimine affords a sulfinylamine stereoisomer when the sulfinylimine starting material is a sulfinylimine stereoisomer, or when the reduction is performed using a stereoselective reducing agent. When a sulfinylimine is reduced, hydrogen atoms are added to the nitrogen and carbon atoms of the imine group. When a sulfinylimine stereoisomer is reacted with a source of a nucleophile, a hydrogen atom is added to the nitrogen atom and the nucleophile to the carbon atom. Examples of sources of nucleophiles include nitriles, Grignard reagents and organolithiums. In one embodiment of the invention, the sulfinylimine is a sulfinylimine stereoisomer. The residue of the alcohol, thiol or amine may also be in stereoisomeric form. Particular mention is made of sulfinylirnines that bear a residue of an alcohol on the sulfinyl group, especially those wherein the residue of the alcohol is a residue of an optionally N-substituted beta-aminoalcohol, thiol or amine, in particular an optionally N-substituted beta-aminoalcohol. In one embodiment, the N-substituted beta-aminoalcohol, thiol or amine may be represented by the general formula (Formula Removed) wherein Ai is R7N or (R7')R7"N, R7 represents hydrogen or -L-R7a in which -L- represents a bond, -CO-, -(CO)O-, -(CO)NR7b-, -SO-, -S02-, or -(S02)0-, each of R7a and R7b independently represents substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, and R7- and R7- are as defined for R7a, or R7- and R7- together with the nitrogen atom to which they are attached and, optionally R8, form an unsubstituted or substituted heterocyclic group, or R7- together with the nitrogen atom to which it is attached and the carbon atom to which the nitrogen atom is attached forms an unsubstituted or substituted heterocyclic group; A2 is O, S or NR7c in which R7c is substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and each of Rs, R9, R10 and R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or Rg and R11 together form a substituted or unsubstituted alkylene or heteroalkylene chain. By way of illustration, an example of a compound in which R7- and R7» together with the nitrogen atom to which they are attached and, optionally R$, form an unsubstituted or substituted heterocyclic group is quinidine. An example of a compound in which R7> together with the nitrogen atom to which it is attached and the carbon atom to which the nitrogen atom is attached forms an unsubstituted or substituted heterocyclic group is the compound of formula (Formula Removed) The residue of the alcohol, thiol or amine is preferably a residue of an alcohol (A2 is O). R7 may represent, for example, -S02-R7a- Examples of particular values for R7a are (l-6C)alkyl, (6-10C)aryl(l-4C)alkyl or (6-lOQaryl in which any aryl group is unsubstituted or substituted by one, two or three substituents selected independently from halogen, (l-4C)alkyl and (l-4C)alkoxy. Thus, examples of particular values for R7 are methanesulfonyl and p-toluenesulfonyl. Examples of particular values for R7- are (l-4C)alkyl groups, such as methyl or butyl. Examples of particular values for R7- are (l-4C)alkyl groups, such as methyl or butyl. Examples of particular values where R7', R7» and the nitrogen atom to which they are attached form an unsubstituted or substituted heterocyclic group are pyrrolidine groups that optionally bear one or two methyl substituents, such as pyrrolidinyl, 2-methylpyrrolidinyl and 2,5-dimethylpyrrolidinyl. Examples of compounds containing groups in which R7>, R7->, Rs, and the nitrogen atom to which they are attached form an unsubstituted or substituted heterocyclic group are quinine, quinidine, cinchonidine, cinchonine, hydroquinine, hydrocinchonidine and ethyl hydrocupreine. Examples of particular values for Rg are hydrogen, (l-4C)alkyl, such as methyl or ethyl, and phenyl. Examples of particular values for R9 are hydrogen, (l-4C)alkyl, such as methyl or ethyl, and phenyl. Examples of particular values for R10 are hydrogen, (l-4C)alkyl, such as methyl or ethyl, and phenyl. Examples of particular values for R11 are hydrogen, (l-4C)alkyl, such as methyl or ethyl, and phenyl. Examples of beta-aminoalcohols wherein A1 is R7N are optionally N-substituted 2-amino-1 -phenylpropanols, 2-amino-2-methyl-1 -phenylpropanols, 1 -amino-1 -phenyl-2-propanols, 1-amino-l-phenyl-2-methyl-2-propanols, l-amino-l-phenyl-2-ethyl-2-butanols, l-amino-2-indanols, 2-amino-l-indanols, l-amino-2-hydroxy-l,2,3,4-tetrahydronaphthalenes and 2-amino-l-hydroxytetrahydronaphthalenes. Examples of beta-aminoalcohols wherein Ai is (R70R7"N are 2-N.N-dimethylamino-1 -phenylpropanol, 2-N,N-dibutylamino-l -phenylpropanol, 2-pyrrolidin-1 -yl-1 -phenylpropanol, 2-(2-methylpyrrolidin-1 -yl)-1 -phenylpropanol, 2-(2,5-dimethylpyrrolidin-1 -yl)-1 -phenylpropanol, 2- N,N-dimethylamino-2-methyl-1 -phenylpropanol, (N-methylpyrrolidin-2-yl)diphenylmethanol, 1 -pyrrolidin-1 -ylindan-2-ol, 3-benzyloxy-2-N,N-dimethylammo-l-phenylpropan-2-ol, quinine, quinidine, hydroquinine, cinchonidine, cinchonine, hydrocinchonidine or ethyl hydrocupreine. Structures of representative beta-aminoalcohols are as follows. (Formula Removed) It has been found that especially high stereoselectivity is associated with Ai is (R7')R7"N. Accordingly, a preference may be expressed for Ai is (R7-)R7"N. Compounds derived from beta-aminoalcohols such as quinine correspond with an alcohol in which R11 is unsubstituted or substituted quinolin-4-yl. Accordingly, it is contemplated that alternative examples of particular values for R11 are quinolin-4-yl which is unsubstituted or substituted by one or two substituents selected independently from (1-4C)alkyl, (l-4C)alkoxy and halogen. Sulflnyhmines that bear on the sulfinyl group a residue of an alcohol, thiol or amine may be prepared by reacting an iminometal, such as an iminomagnesium chloride, with a compound of formula Z'-SO-R in which Z' represents a leaving atom or group, such as a fluorine, chlorine or bromine atom, and R represents a residue of an alcohol, thiol or amine. Sulfinylirnines in which the sulfmyl group bears a residue of an optionally N-substituted beta-aminoalcohol, thiol or amine may advantageously be prepared by contacting an irninometal, such as an iminomagnesium chloride, with a 1,2,3-oxathiazolidine-S-oxide, 1,2,3-dithiazolidine-S-oxide or 1,2,3-azathiazolidine respectively. According to a preferred aspect, therefore, the sulfinyhmine used in the method has been prepared by contacting an irninometal with a 1,2,3-oxathiazolidine-S-oxide, 1,2,3-dithiazolidine-S-oxide or 1,2,3-azathiazolidine-S-oxide respectively, especially a 1,2,3-oxathiazolidine-S-oxide, 1,2,3-dithiazolidine-S-oxide or 1,2,3-azathiazolidine-S-oxide stereoisomer (which affords a sulfinyhmine stereoisomer in which the sulfmyl group bears a residue of an optionally N-substituted beta-aminoalcohol, thiol or amine also in stereoisomers form). 1,2,3-Oxathiazolidine-S-oxides, 1,2,3-dithiazolidine-S-oxides and 1,2,3-azathiazolidine-S-oxides may be prepared by reacting respectively an optionally N-substituted beta-aminoalcohol, thiol or amine with a sulfonyl halide, such as thionyl chloride in the presence of an amine base, such as a pyridine derivative. The 1,2,3-oxathiazolidine-S-oxide, 1,2,3-dithiazolidine-S-oxide or 1,2,3-azathiazolidine-S-oxide may be, for example, a compound of formula 3 or 3' (Formula Removed) wherein Ai is R7N or (RT)Rr Q" in which Q- is an anion, R7 represents hydrogen or -L-R7a in which -L- represents a bond, -CO-, -(CO)O-, -(CO)NR7b-, -SO-, -S02-, or -(S02)0-, each of R7a and R7b independently represents substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, and R7- and R7» are as defined for R7a, or R7- and R7» together with the nitrogen atom to which they are attached and, optionally Rg, form an unsubstituted or substituted heterocyclic group, or R7- together with the nitrogen atom to which it is attached and the carbon atom to which the nitrogen atom is attached forms an unsubstituted or substituted heterocyclic group; A2 is O, S or NR7c in which R7c is substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and each of Rg, Rg, R10 and R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or R8 and R11 together form a substituted or unsubstituted alkylene or heteroalkylene chain. The iminometal may be, for example, a compound of formula 1' (Formula Removed) wherein M is CdZ, BaZ, Na, K, MgZ, ZnZ, Li, MnZ, CuZ, TiZ3 or In and Z is an anion. When the sulfmylamine has been prepared from a sulfinylimine in which the sulfmyl group bears the residue of an optionally N-substituted beta-aminoalcohol, thiol or amine, treatment of the sulfmylamine with a reagent suitable for the cleavage of a sulfur-nitrogen bond, such as an acid, affords as a second reaction product the optionally N-substituted beta-aminoalcohol, thiol or amine. This alcohol, thiol or amine may advantageously be recycled by converting it into 1,2,3-oxathiazolidine-S-oxide, 1,2,3-oxadiathiazolidine-S-oxide or 1,2,3-azathiazolidine-S-oxide. According to a preferred aspect therefore, the method further comprises recovering optionally N-substituted beta-aminoalcohol, thiol or amine, converting this into 1,2,3-oxathiazolidine-S-oxide and reacting this with an iminometal as described hereinabove. A sulfinylimine may be reduced to a sulfinylamine stereoisomer using any suitable reducing agent. Thus, it will be appreciated that the reducing agent may be any reducing agent capable of reducing a sulfinylimine to a sulfinylamine, provided that if the sulfinylimine is not a sulfinylimine stereoisomer, then the reducing agent is a stereoselective reducing agent. Examples of reducing agents include hydrogen, in the presence of a group VIII metal catalyst, such as palladium on carbon; boranes; hydrogen transfer reagents, such as cyclohexene and formic acid in the presence of palladium on carbon, and hydride-type reducing agents. Examples of stereoselective reducing agents include asymmetric hydrogenation agents, asymmetric transfer hydrogenation reagents and asymmetric oxazaborolidine agents. Examples of asymmetric hydrogenation agents are described in Burk MJ, Allen JG, Kiesman WF: Highly regio- and enantioselective catalytic hydrogenation of enamides in conjucated diene systems: Synthesis and application of Y,8-unsaturated amino acids. J. Am. Chem. Soc (1998) 120:657-663; Burk MJ, Casy G, Johnson NB: A three-step procedure for asymmetric catalytic reductive amidation of ketones. J. Org. Chem (1998) 63:6084-6085; Zhang F-Y, Pai C-C, Chan ASC: Asymmetric synthesis of chiral amine derivatives through enantioselective hydrogenation with a highly effective rhodium catalyst containing a chiral bisaminophosphine ligand. J. Am. Chem. Soc (1998) 120:5808; and Doucet H, Ohkuma T, Murata K, Yokozawa T, Kozawa M, Katayama E, England AF, Ikariya T, Noyori N: trans-[RuCl2(phosphane)2(l,2-diamine)] and chiral trans-[RuCl2(phosphane) (1,2-diamine)]: Shelf-stable precatalysts for the rapid, productive, and stereoselective hydrogenation of ketones. Angew. Chem. Int. Ed (1998) 37:1703-1707. Examples of asymmetric transfer hydrogenation reagents are described in Murata K, Ikariya T, Noyori R: New chiral Rhodium and Iridium complexes with chiral diamine ligands for asymmetric transfer hydrogenation of aromatic ketones. J. Org. Chem (1999) 64:2186-2187 and references cited therein. Examples of asymmetric oxazaborolidine agents are described in Hett R, Senanayake CH, Wald SA: Conformational toolbox of oxazaborolidine catalysts in the enantioselective reduction of α-bromo-ketone for the synthesis of (R,R)-formoterol. Tetrahedron Lett. (1998) 39:1705-1708 and references cited therein. A preferred reducing agent is a hydride type reducing agent, for example an alkali metal (lithium, sodium or potassium) aluminium hydride or borohydnde. The aluminium or boron atoms may be unsubstituted or substituted by one, two or three substituents, such as alkyl, alkoxy or aryl group, sodium borohydride, lithium aluminium hydride, lithium borohydride, lithium triethylborohydride, diisobutylaluminium hydride, lithium trimethoxyaluminium hydride or sodium bis(2-methoxy)aluminium hydride. Particular mention may be made of sodium borohydride. The reduction is conveniently performed at a temperature in the range of from -75 to 25°C. Convenient solvents include halogenated hydrocarbons, such as dichloromethane, ethers, such as diethyl ether, methyl t-butyl ether (MTBE) or tetrahydrofuran and alcohols such as methanol or ethanol. Particular mention may be made of ethers, especially tetrahydrofuran. The reduction with the hydride type reducing agent may be performed in the presence of a Lewis acid, such as boron tnfluoride, a titanium tetra(l-4C)alkoxide, such as titanium tetraethoxide, titanium tetrapropoxide, titanium tetraisopropoxide; a titanium tetrahalide, such as titanium tetrachloride; a zirconium tetra(l-4C)alkoxide, such as zirconium tetraethoxide or zirconium tetra-t-butoxide; a zinc dihalide, such as zinc dichloride, or a magnesium dihalide, such as magnesium dibromide. Particular mention may be made of titanium tetra(l-4C)alkoxides, for example used with sodium borohydride. The reagent suitable for cleavage of a sulfur-nitrogen bond may be, for example, an acid. Examples of acids include hydrohalic acids, such as hydrochloric acid; sulfonic acids, such as p-toluenesulfonic acid; pyridinium sulfonates, such as pyridium-p-toluenesulfonate; Amberlyst H-15, boric acid and acetic acid. Particular mention may be made of hydrochloric acid. The cleavage of the sulfur-nitrogen bond is conveniently performed at a temperature in the range of from -50 to 50 °C. Examples of biologically active amine stereoisomers include the stereoisomers of Alacepril, Benazepril, Benazeprilate, Ceronapril, Cilazapril, Cilazaprilat, Delapril, Enalapril, Enalaprilat, Fasidotril, Fosinopril, Imidapril, Imidaprilat, Libenzapril, Lisinopril, Moexipril, Moexiprilat, Moveltipril, Pentopril, Perindopril, Quinapril, Quinaprilat, Ramipril, Sampatrilat, Spirapril, Spiraprilat, Temocapril, Temocaprilate, Trandolapril, Trandolaprilate, Utibapril, Utibaprilat, Zabicipril, Zabiciprilat, Bucillamine, Penicillamine, Thiamphenicol, Cefprozil, Cephalexin, Cephaloglycin, Cilastatin, Alafosfalin, Ethambutol, Sertraline, Tametraline, Acetylcysteine, Selegiline, Azaserine, Dorzolamide, Colchicine, Dilevalol, Enalapril, Methyldopa, Metaraminol, Acivicin, Melphalan, Ubenimex, Tmsulosin, Tirofiban, Dilevalol, N-dodecyl-N-memylephedrmium, Ofenucine, Tinofedrine, Aceglutamide, 1-ephedrine, levopropylhexedrine, (+)-and (-)-Norephedrine, Phenylpropanolamine, Pseudoephedrine, d-farm, (R)-and (S)-Tamsulosin, Dimepheptanol, Lofentanil, Tilidine hydrochloride (+)-trans, Ciramadol, Enadoline, Lefetamine, Spiradoline, (+)-Etoxadrol, Levoxadrol, (R)-Amphetamine, Clobenzorex, Dexfenfluramine, Dextroamphetamine, Etilamfetarnine, Fenfluramine, Levofenfluramine, Phenylpropanolamine, Cetirizine, (R)- and (S)-Baclofen, (R)- and (S)-Sibutramine, and pharmaceutically acceptable salts thereof. In one embodiment, the amine stereoisomer is a compound of formula 5 or 51 (Formula Removed) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or prodrug thereof, wherein R5 and R6 are independently substituted or xmsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or R5 and R6 together with the carbon atom to which they are attached form a substituted or unsubstituted cycloalkyl group, and R12 and R13 together with the nitrogen atom to which they are attached form a heterocycle, or each of R12 and R13 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl, and the sulfinylamine stereoisomer is a compound of formula 4 or 4' (Formula Removed) wherein A1' represents R7N or (R7-)R7"N. An example of a value for A2 is O. According to another aspect, the present invention provides a compound of formula (Formula Removed) wherein: R5 and R6 are independently substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or R5 and Rg together with the carbon atom to which they are attached form a substituted or unsubstituted cycloalkyl group; Ai is R7N or (R7')R7-N; R7 represents hydrogen or -L-R7a in which -L- represents a bond, -CO-, -(CO)O-, -(CO)NR7b-, -SO-, -SO2-, or -(S02)0-, each of R7a and R7b independently represents substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, and R7' and R7" are as defined for R7a, or R7- and R7- together with the nitrogen atom to which they are attached and, optionally Rg, form an unsubstituted or substituted heterocyclic group, or R7> together with the nitrogen atom to which it is attached and the carbon atom to which the nitrogen atom is attached forms an unsubstituted or substituted heterocyclic group; A2 is O, S or NR7C in which R7c is substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and each of Rg, R9, R10 and R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or R8 and R\ 1 together form a substituted or unsubstituted alkylene or heteroalkylene chain; A2 is O, S or NR7c in which R7c is substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and each of R8, R9, R10 and R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or Rg and R11 together form a substituted or unsubstituted alkylene or heteroalkylene chain, or a salt thereof. According to yet another aspect, the present invention provides a compound of formula (Formula Removed) wherein Ai is (R?)R7'N+ Q" in which Q- is an anion and each of R7 and R7' independently represents substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or two substituents R7 together with the nitrogen atom to which they are attached and, optionally Rs, form an unsubstituted or substituted heterocyclic group, or one R7 substituent together with the nitrogen atom to which it is attached and the carbon atom to which the nitrogen atom is attached form an unsubstituted or substituted heterocyclic group; A2 is O, S or NR7c in which R7c is substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and each of Rs, R9, R10 and R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or Rg and Ri} together form a substituted or unsubstituted alkylene or heteroalkylene chain, or a salt thereof. Compounds of formula 3" are also useful in a method of preparing sulfanamide stereoisomers, such as the stereoisomers of t-butylsulfinamide. According to yet another aspect therefore, the present invention provides a method of preparing a sulfinamide stereoisomer, which comprises reacting a compound of formula 3" as defined hereinabove with a first organometallic reagent of formula R'M to afford a compound of formula (Formula Removed) and then either reacting this compound with a second organometallic reagent of formula R2M to afford a sulfoxide stereoisomer of formula R^SO-R2 in which R1 and R2 each independently represents an organic group, or with an alkali metal amide to afford a sulfinylamine stereoisomer. The choice of suitable first and second organometallic reagents and amides, and suitable reaction conditions, will be readily apparent to those skilled in the art. The suitable reagents include Grignard reagents, organolithium reagents, organocopper reagents and organoalurainium reagents. An example of a first or second organometallic reagent is an organomagnesium halide, such as an alkyl or aiylmagnesium halide. Examples of an amide are lithium amide and lithium hexamethylenedisilylamide. Examples of uses of these reagents are described in the examples herein. Particularly good results have been obtained using compounds of formula 3" that are derived from quinine. As used herein, the term "prodrug" means a derivative of a compound that can hydrolyze, oxidize, or otherwise react under biological conditions (in vitro or in vivo) to provide the compound. Examples of prodrugs include, but are not limited to, derivatives of desmethylsibutramine and didesmethylsibutramine that comprise biohydrolyzable moieties such as biohydrolyzable amides, biohydrolyzable esters, biohydrolyzable carbamates, biohydrolyzable carbonates, biohydrolyzable ureides, and biohydrolyzable phosphate analogues. Other examples of prodrugs include derivatives of desmethylsibutramine and didesmethylsibutramine that comprise -NO, -NO2, -ONO, and -ONO2 moieties. As used herein, prodrugs of didesmethylsibutramine do not mclude desmethylsibutramine or sibutramine, and prodrugs of desmethylsibutramine do not include sibutramine. As used herein, the terms "biohydrolyzable carbamate," "biohydrolyzable carbonate," "biohydrolyzable ureide," "biohydrolyzable phosphate" mean a carbamate, carbonate, ureide, or phosphate, respectively, of a compound that either: 1) does not interfere with the biological activity of the compound but can confer upon that compound advantageous properties in vivo, such as uptake, duration of action, or onset of action; or 2) is biologically less active or inactive but is converted in vivo to the biologically active compound. Examples of biohydrolyzable carbamates include, but are not limited to, lower alkylamines, substituted ethylenediamines, aminoacids, hydroxyalkylamines, heterocyclic and heteroaromatic amines, and polyether amines. As used herein, the term "biohydrolyzable ester" means an ester of a compound that either: 1) does not interfere with the biological activity of the compound but can confer upon that compound advantageous properties in vivo, such as uptake, duration of action, or onset of action; or 2) is biologically less active or inactive but is converted in vivo to the biologically active compound. Examples of biohydrolyzable esters include, but are not limited to, lower alkyl esters, alkoxyacyloxy esters, alkyl acylamino alkyl esters, and choline esters. As used herein, the term "biohydrolyzable amide" means an amide of a compound that either: 1) does not interfere with the biological activity of the compound but can confer upon that compound advantageous properties in vivo, such as uptake, duration of action, or onset of action; or 2) is biologically less active or inactive but is converted in vivo to the biologically active compound. Examples of biohydrolyzable amides include, but are not limited to, lower alkyl amides, a-amino acid amides, alkoxyacyl amides, and alkylaminoalkylcarbonyl amides. As used herein, the term "pharmaceutically acceptable salt" refers to a salt prepared from a pharmaceutically acceptable non-toxic inorganic or organic acid. Suitable non-toxic acids include, but are not limited to, acetic, benzenesulfonic, benzoic, camphorsulfonic, citric, ethenesulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, malic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric, and p-toluenesulfonic acids. For example, specific pharmaceutically acceptable salts are hydrochloride, maleic acid, and tartaric acid salts. As used herein and unless otherwise indicated, the term "alkyl" includes saturated monovalent linear, branched, and cyclic hydrocarbon radicals. An alkyl group can include one or more double or triple bonds. It is understood that cyclic alkyl groups comprise at least three carbon atoms. As used herein and unless otherwise indicated, the term "heteroalkyl" means branched or linear alkyl having from 1 to 8, more preferably from 1 to 4 carbon atoms and including at least one heteroatom, including N, P, O, or S. Examples include, but are not limited to, compounds of the formula: wherein X is O, P, NH, or S. As used herein and unless otherwise indicated, the term "lower alkyl" means branched or linear alkyl having from 1 to 6, more preferably from 1 to 4 carbon atoms. Examples include, but are not limited to, methyl, ethyl, propyl, isopropyl, isobutyl, and tertiary butyl. As used herein and unless otherwise indicated, the term "aryl" includes an organic radical derived from an aromatic hydrocarbon by removal of one hydrogen, such as phenyl or naphthyl. As used herein and unless otherwise indicated, the term "aralkyl" means an aryl substituted with one or linear, branched, or cyclic alkyl groups. Aralkyl moieties can be attached to other moieties through their aryl or alkyl components. As used herein and unless otherwise indicated, the terms "heterocyclic group" and "heterocycle" include aromatic and non-aromatic heterocyclic groups containing one or more heteroatoms each selected from O, S and N. Non-aromatic heterocyclic groups include groups having only 3 atoms in their ring system, but aromatic heterocyclic groups (i.e., heteroaryl groups) must have at least 5 atoms in their ring system. Heterocyclic groups include benzo-fused ring systems and ring systems substituted with one or more oxo moieties. An example of a 4 membered heterocyclic group is azetidinyl (derived from azetidine). An example of a 5 membered heterocyclic group is thiazolyl, and an example of a 10 membered heterocyclic group is quinolinyl. Examples of non-aromatic heterocyclic groups include, but are not limited to, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperidino, morpholino, thiomorpholino, thioxanyl, piperazinyl, azetidinyl, oxetanyl, thietanyl, homopiperidinyl, oxepanyl, thiepanyl, oxazepinyl, diazepinyl, thiazepinyl, 1,2,3,6-tetrahydropyridinyl, 2-pyrrolinyl, 3-pyrrolinyl, indolinyl, 2H-pyranyl, 4H-pyranyl, dioxanyl, 1,3-dioxolanyl, pyrazolinyl, dithianyl, dithiolanyl, dihydropyranyl, dihydrothienyl, dihydrofuranyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, 3-azabicyclo[3.1.0]hexanyl, 3-azabicyclo[4.1.0]heptanyl, 3H-indolyl, quinolizinyl, and substituted derivative thereof. Examples of aromatic heterocyclic groups include, but are not limited to, pyridinyl, methylpyridine analgoues, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, quinolinyl, isoquinolinyl, indolyl, benzimidazolyl, benzoimidazoles, benzofuranyl, cinnolinyl, indazolyl, indolinyl, indolizinyl, phthalazinyl, pyridazinyl, triazinyl, isoindolyl, pteridinyl, purinyl, oxadiazolyl, thiadiazolyl, furazanyl, benzofurazanyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinazolinyl, quinoxalinyl, naphlhyridinyl, furopyridinyl, and substituted derivatives thereof. The foregoing groups, as derived from the compounds listed above, may be C-attached or N-attached where such attachment is possible. For instance, a group derived from pyrrole can be pyrrol- 1-yl (N-attached) or pyrrol-3-yl (C-attached). As used herein and unless otherwise indicated, the term "heteroaryl" means an aromatic heterocycle. As used herein and unless otherwise indicated, the term "substituted" as used to describe a compound or chemical moiety means that at least one hydrogen atom of that compound or chemical moiety is replaced with a second chemical moiety. Examples of second chemical moieties include, but are not limited to: halogen atoms (e.g., chlorine, bromine, and iodine); C1-C6 linear, branched, or cyclic alkyl (e.g., methyl, ethyl, butyl, tert-butyl, and cyclobutyl); hydroxyl; thiols; carboxylic acids; esters, amides, silanes, nitriles, thioethers, stannanes, and primary, secondary, and tertiary amines (e.g., -NH2, -NH(CH3), -N(CH3)2, and cyclic amines). Preferred second chemical moieties are chlorine, hydroxyl, methoxy, amine, thiol, and carboxylic acid. As used herein and unless otherwise indicated, a composition that is "substantially free" of a compound means that the composition contains less than about 20% by weight, more preferably less than about 10% by weight, even more preferably less than about 5% by weight, and most preferably less than about 3% by weight of the compound. As used herein and unless otherwise indicated, the term "stereomerically pure" means a composition that comprises one stereoisomer of a compound and is substantially free of other stereoisomers of that compound. For example, a stereomerically pure composition of a compound having one chiral center will be substantially free of the opposite enantiomer of the compound. A stereomerically pure composition of a compound having two chiral centers will be substantially free of other diastereomers of the compound. A typical stereomerically pure compound comprises greater than about 80% by weight of stereoisomer of the compound and less than about 20% by weight of other stereoisomers the compound, more preferably greater than about 90% by weight of one stereoisomer of the compound and less than about 10% by weight of the other stereoisomers of the compound, even more preferably greater than about 95% by weight of one stereoisomer of the compound and less than about 5% by weight of the other stereoisomers of the compound, and most preferably greater than about 97% by weight of one stereoisomer of the compound and less than about 3% by weight of the other stereoisomers of the compound. As used herein and unless otherwise indicated, the term "enantiomerically pure" means a stereomerically pure composition or compound. As used herein, compounds encompassed by the term "1,2,3-oxathiazolidine-S-oxides, 1,2,3-dithiazolidine-S-oxides, 1,2,3-azadithiazoline-S-oxides and derivatives thereof are generally of the formula: (Formula Removed) Corresponding iminosulfonates obtainable by reaction of these compounds with an iminometal are of the formula (Formula Removed) Corresponding optionally N-substituted beta-aminoalcohols, thiols and amines are represented by the formulae: (Formula Removed) In this embodiment, particular mention is made a method in which A2 is O, R5 and R$ are independently substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; the 1,2,3-oxathiazolidine-S-oxide is a compound of the formula 3 or 3' (Formula Removed) in which R7 represents hydrogen or -L-R7a in which L represents a bond or S02 and R7a represents substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; Z in the iminometal of formula 1 'is CI, Br or I.; and the sulfinylamine stereoisomer is a compound of formula (Formula Removed) In a preferred embodiment, the term "1,2,3-oxathiazolidine-S-oxides and derivatives thereof encompasses compounds of the formula: (Formula Removed) It should be noted that if there is a discrepancy between a depicted structure and a name given that structure, the depicted structure is to be accorded more weight. In addition, if the stereochemistry of a structure or a portion of a structure is not indicated with, for example, bold or dashed lines, the structure or portion of the structure is to be interpreted as encompassing all stereoisomers of it. A first embodiment of the invention encompasses a method of preparing chiral amines of formulas 5 or 5': (Formula Removed) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, or prodrug thereof, wherein R5 and R6 are independently substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl. The method of preparing chiral amines of formula 5: or a pharmaceutically acceptable salt, soJyate, clathrate, hydrate, or prodrug thereof, (Formula Removed) NH2 5 wherein R5 and R (Formula Removed) with a compound of formula 1': (Formula Removed) wherein under conditions suitable for the formation of a compound of formula 4: (Formula Removed) sulfur-nitrogen bond and for the formation of a stereomencally pure amine. In an optional embodiment, the amine compound of formula 5 is treated with an alkylating agent (e.g., alkyl iodide) under conditions suitable for the formation of mono- or di-alkylated amines of formulas' and5": (Formula Removed) wherein R]2 and R11 is independently substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl. In another embodiment, the amine compound of formula 5 is optionally treated with a methylating agent (e.g., methyl iodide) under conditions suitable for the formation of mono- or di-rnethylated amines of formula 6' and 6": (Formula Removed) One of ordinary skill in the art will readily recognize that compounds of formula 5' can be prepared by following the above procedure but replacing compound 3 with compound 3': (Formula Removed) A second embodiment of the invention encompasses a method of preparing a compound of Formula 7: (Formula Removed) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, or prodrug thereof, wherein Ri4 is substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl, and Ri5 and Ri6 together with the nitrogen atom to which they are attached form a heterocycle, or each of R15 and Ri6 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl, which comprises contacting a compound of Formula 8: (Formula Removed) wherein M is CdZ, BaZ, Na, K, MgZ, ZnZ, Li, MnZ, CuZ, TiZ3, or In, and Z is CI, Br, I, aryl, aralkyl, alkoxy, or heterocycle with a compound of formula 3: (Formula Removed) under conditions suitable for the formation of a compound of formula 9: (Formula Removed) followed by hydrogenation and work-up under conditions suitable for the cleavage of a sulfur-nitrogen bond and for the formation of a stereomerically pure amine of formula 7. In another embodiment, the compound of formula 7 is treated with D-tartaric acid under conditions suitable for the formation of a compound of formula 10: (Formula Removed) One of ordinary skill in the art will readily recognize that compounds of formula T can be prepared by following the above procedure but replacing compound 3 with (Formula Removed) compound 3': In a preferred method, the compounds of formulas S, 6, 7, and 10 are stereomerically pure. In another preferred method, the compounds of Formula 5, 6, and 7 are provided as a pharmaceutically acceptable salt. Examples of preferred pharmaceutically acceptable salts include, but are not limited to, acetic, benzenesulfonic, benzoic, camphorsulfonic, citric, ethenesulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, malic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric, and p-toluenesulfonic salts. In another preferred method, the reagent capable of cleaving a nitrogen-sulfur bond is an acid. A preferred acid is HC1. The compound of Formulas 5 or 7, respectively, can be prepared by contacting a compound of Formula 4 or 9: (Formula Removed) with a Lewis acid and a compound of the formula RM, wherein R is an alkyl, aryl, or arylalkyl and M is CdZ, BaZ, Na, K, MgZ, ZnZ, Li, MnZ, CuZ, TiZ3, or In, and Z is CI, Br, I, aryl, aralkyl, alkoxy, or heterocycle under conditions suitable for the formation of the compound of Formula 5 or 7. The compound of Formula 1' can be prepared by contacting a compound of Formula 11: (Formula Removed) with a compound of formula 12: (Formula Removed) 12 under conditions suitable for the formation of a compound of formula 1': (Formula Removed) 13 Compounds of formula 12 are generally formed by treating a compound of formula R5-Hal 13 with a metal or Lewis acid under conditions suitable for the formation of a compound of formula 12. Metals used to generate compounds of formula 12 include, but are not limited to CdZ, BaZ, Na, K, MgZ, ZnZ, Li, MnZ, CuZ, TiZ3, or In, wherein Z is CI, Br, aryl, aralkyl, alkoxy, or heterocycle. Examples of Lewis acids include, but are not limited to, BF3OEt2, SnCl4, Sc(OTf)2, Al(alkyl)3, Ti(alkyl)4, Ti(alkoxy)4, TiCU, Zn(OTf)2, Mg(OTf)2,TiHalk(0-i-Pr)4-k (wherein Hal is F, CI, Br, or I, and k is 1, 2, or 3), and derivatives thereof. Suitable solvents for obtaining compounds 12 include, but are not limited to, dichloromethane, diethyl ether, tetrahydrofuran, benzene, toluene, xylene, hydrocarbon solvents {e.g., pentane, hexane, and heptane), and mixtures thereof. Preferably, the organic solvent is toluene. The compound of formula 3: (Formula Removed) can be prepared by treating a compound of formula 2; (Formula Removed) with thionyl chloride and a base at low temperature, preferably less than 0 °C, more preferably less than -25 °C, and most preferably less than -40 °C. Preferably, the base is added at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. The base can be added as an organic solution or in undiluted form. Preferably, the base will have a base strength sufficient to deprotonate a proton, wherein the proton has a pKa of greater than about 15, preferably greater than about 20. As is well known in the art, the pKa is a measure of the acidity of an acid H-A, according to the equation pKa = -log Ka, wherein Ka is the equilibrium constant for the proton transfer. The acidity of an acid H-A is proportional to the stability of its conjugate base "A. For tables listing pKa values for various organic acids and a discussion on pKa measurement, see March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 248-272, incorporated herein by reference. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, n-butyllithium, tert-butyllithium, sec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride. Solvents suitable for reacting compounds 2 with base include, but are not limited, to dimethyl sulfoxide, dichloro-methane, ethers, and mixtures thereof, preferably tetrahydrofuran. One of ordinary skill in the art will readily recognize that compounds of formula 3': (Formula Removed) can be formed by treating a compound of formula 2': (Formula Removed) with thionyl chloride and base under conditions described above. In a preferred method, the compound of Formula 3 or 3' is stereomerically pure, as shown below: (Formula Removed) A third embodiment of the invention encompasses a method of preparing a compounds of formula 14 and 14': (Formula Removed) and salts, solvates, clathrates, and hydrates thereof, wherein each of R15 and Ri6 is described above. In a preferred embodiment, R15 and Ri6 are independently hydrogen or alkyl. In a more preferred embodiment, R15 and R[6 are independently hydrogen or methyl. In an even more preferred embodiment, Ri5 and R16 are both hydrogen. The embodiment of the invention encompasses treating a compound of formula 15: (Formula Removed) with a compound of formula z'-BuMg-X, wherein X is a halogen, preferably Br or I, more preferably Br under conditions suitable for the formation of an intermediate of formula: (Formula Removed) followed by treating with a compound of formula 3: (Formula Removed) under conditions suitable for the formation of a compound of formula 16: (Formula Removed) and followed by hydrogenation and work-up under conditions suitable for the cleavage of a sulfur-nitrogen bond and for the formation of a stereomerically pure amine of formula 13 or salts, solvates, clathrates, and hydrates thereof. In a preferred embodiment, the compound of formula 3 above has the following structure: (Formula Removed) In a preferred method, the compounds of formula 13 are stereomerically pure. In another preferred method, the compounds of Formula 13 are provided as a pharmaceutically acceptable salt, preferably as a tartaric acid salt. In another embodiment, the method encompasses making a compound of formula 14': (Formula Removed) under conditions set forth above using a compound of formula 3': (Formula Removed) In a preferred embodiment, the compound of formula 3' has the following structure: (Formula Removed) 5. EXAMPLES Sibutramine, desmethylsibutramine, didesmethylsibutramine, and derivatives of each can be readily prepared according to the method represented below in Scheme III. This scheme, like others disclosed herein, is merely representative of a method of the invention, and is not to be construed as limiting its scope in any way. 5.1. PREPARATION OF STEREOMERICALLY PURE 1.2.3-OXATHIAZOLIDINE-S-OXIDES The synthesis of stereomerically pure (R)- and (S)- 1,2,3-oxathiazolidine-S-oxides is described in Scheme 3. (Scheme Removed) Scheme 3 Scheme 3 illustrates the synthesis of Rs- and Ss-l,2,3-oxathiazolidine-jS'-oxides in stereomerically pure form. Generally, compounds of formula 3 and 3' are formed by contacting compounds of formula 2 or 2', respectively with thionyl chloride at low temperature (e.g., -45 °C) in the presence of a base. The base can be added as an organic solution or in undiluted form. Preferably, the base will have a base strength sufficient to deprotonate a proton, wherein the proton has a pKa of greater than about 15, preferably greater than about 20. As is well known in the art, the pKa is a measure of the acidity of an acid H-A, according to the equation pKa = -log K*, wherein Ka is the equilibrium constant for the proton transfer. The acidity of an acid H-A is proportional to the stability of its conjugate base A". For tables listing pKa values for various organic acids and a discussion on pKa measurement, see March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 248-272, incorporated herein by reference. Suitable bases include, but are not limited to, amine bases such as trialkylamine, for example triethylamine and pyridine derivatives, such as pyridine, lutidines, collidines and quinoline. Solvents suitable for reacting compounds 2 with base include, but are not limited, to dimethyl sulfoxide, dichloro-methane, ethers, and mixtures thereof, preferably tetrahydrofuran. 5.2. PREPARATION OF STEREOMERICALLY PURE IMINES Stereomerically pure imines can be prepared as shown in Scheme 4. (Scheme Removed) Scheme 4 Compounds 4 and 4' can generally be prepared by adding a metal-imine complex to a compound of formula 3 or 3', respectively. In particular, compounds of formula 4 and 4' are generally formed by treating a nitrile with a metal or Lewis acid under conditions suitable for the formation of a metal imine complex. Metals used to generate compounds of formula V include, but are not limited to CdZ, BaZ, Na, K, MgZ, ZnZ, Li, MnZ, CuZ, TiZ3, or In, wherein Z is CI, Br, aryl, aralkyl, alkoxy, or heterocycle. Examples of Lewis acids include, but are not limited to, BF3OEt2, SnCl4, Sc(OTf)2, Al(alkyl)3, Ti(alkyl)4, Ti(alkoxy)4, TiCU, Zn(OTf)2, Mg(OTf)2,TiHalk(0-i-Pr)4-k (wherein Hal is F, CI, Br, or I, and k is 1,2, or 3), and derivatives thereof. Suitable solvents for obtaining compound 4 and 4' include, but are not limited to, dichloromethane, diethyl ether, tetrahydrofuran, benzene, toluene, xylene, hydrocarbon solvents (e.g., pentane, hexane, and heptane), and mixtures thereof. Preferably, the organic solvent is toluene. 5.3. REDUCTION OF STEREOMERICALLY PURE IMINES Stereomerically pure imines can be reduced to stereomerically pure amines as Uustrated in Scheme 5. (Scheme Removed) Scheme 5 Scheme 5 illustrates the synthesis of stereomerically pure (R)- and (S)-amine -compounds. Next, compounds 4 and 4' are first treated with a reducing agent to reduce the imine to a stereomerically pure amine with a suitable reducing agent. A wide variety of reagents are available for reduction of such esters to alcohols, e.g., see M. Hudlicky, Reductions in Organic Chemistry, 2nd ed., 1996 pp. 212-217, hereby expressly incorporated herein by reference. Preferably, the reduction is effected with a hydride type reducing agent, for example, sodium borohydride, lithium aluminum hydride, lithium borohydride, lithium triethyl borohydride, diisobutylaluminum hydride, lithium trimethoxyaluminum hydride, or sodium bis(2-methoxy)aluminum hydride. Preferably, the reduction is conducted by adding an organic solution of compounds 4 or 4' to a stirred mixture comprising a reducing agent, preferably sodium borohydride hydride, and an organic solvent. During the addition, the reaction mixture is maintained at a constant temperature within the range of about -20 °C to about 80 °C, preferably at about room temperature. Organic solvents suitable for reduction include, but are not limited to, dichloromethane, diethyl ether, tetrahydrofuran or mixtures thereof, preferably tetrahydrofuran. After the addition, the reaction mixture is stirred at a constant temperature within the range of about 0 °C to about -45 °C, until the reaction is substantially complete as determined by using an appropriate analytical method, preferably thin-layer chromatography or high-performance-liquid chromatography. Then the reaction an acid is added to the reaction mixture to facilitate cleavage of the sulfur-nitrogen bond. The sulfur-nitrogen bond is preferably cleaved with an acid. Suitable cleavage reagents include, but are not limited to, aqueous hydrochloric acid,P-toluenesulfonic acid in methanol, pyridinium-p-toluenesulfonate in ethanol, Amberlyst H-15 in methanol, boric acid in ethylene-glycol-monoethylether, acetic acid in a water-tetrahydrofuran mixture, aqueous hydrochloric acid is preferred. Purification and separation of the stereoisomers (i.e., enantiomers or diastereomers) can be achieved by methods known in the art, for example, conversion to a chiral salt and crystallization, chiral chromatography, or chiral HPLC. 5.4. PREPARATION OF ENANTIOMERICALLY PURE (Jg)-DIDESMETHYLSIBUTRAMINE Enantiomerically pure (R)-didesmethylsibutramine can be prepared as shown below in Schemes 6. (Scheme Removed) Scheme 6 wherein each of R7, R8, R9, Ri0, and R11 are defined above. 5.5. PREPARATION OF ENANTIOMERICALLY PURE (SVDIDESMETHYLS1BUTRAMINE Enantiomerically pure (S)-didesmethylsibutramine can be prepared as shown below in Schemes 7. (Scheme Removed) Scheme 7 wherein each of R7, Rg, R9, Rio, and R11 are defined above. 5.6. PREPARATION OF (r)-{l-[l-(4-CHLORO-PHENYL)- CYCLOBUTYL]-3-METHYL-BUTYLIDENE}-SULFINAMIC ACED(l^,2/?)-l-PHENYL-2-(4-METHYLPHENYL SULFONYLAMINOVPROPYL ESTER (Formula Removed) To a 100 mL three-necked flask equipped with a magnetic stir bar, an argon inlet, a thermometer probe and rubber septum, was charged l-(4-chloro-phenyl)-cyclobutane-carbonitrile (CCBC) (5.0 g, 25.0 mmol, 96%), toluene (20 mL) and isobutyl magnesium chloride (20 mL, 0.9 M in MTBE). The reaction mixture was distilled to the internal temperature of > 100 °C and the resulting mixture refluxed for 2 h. After cooling to room temperature, the mixture (8.5 mL) was added slowly to a solution of (2S, AR, 5S)-( 4-Methyl-5-phenyl-3-(4-methyl phenyl sulfonyl)-[l,2,3]-oxathiazolidine-2-oxide (2.0 g) in THF (14 mL) at -78 °C. The mixture was stirred at -78 °C for 4 h, warmed to 10 °C with stirring and the reaction was monitored by TLC. The reaction was quenched by slow addition of saturated aqueous NaHCOs solution (10 mL) and diluted with ethyl acetate (20 mL). The organic phase was washed with 20% aqueous NaCl solution and dried over Na2S04. After evaporation of the organic solvent to dryness, the residue was purified by chromatography using CHaCb/EtOAc (9.6:0.4) as a eluate to yield the title compound (2.8 g, 80%). 1H NMR (CDC13): δ 0.640 (d, J = 6.0 Hz, 6H), 1.043 (d, J = 6.6 Hz, 3H), 1.660 (b, 1H), 1.835-1.912 (m, 2H), 2.223-2.308 (m, 2H), 2.417 (s, 3H), 2.417-2.536 (m, 2H), 2.733-2.885 (m, 2H), 3.670-3.748 (m, 1H), 5.5.562 (d, J = 2.1 Hz, 1H), 5.905 (d, J = 9.0 Hz, 1H), 7.125-7.151 (m, 3H), 7.224-7.366 (m, 8H), 7.851 (d, J = 8.4 Hz, 2H). I3C NMR (CDCl3): δ 15.19, 15.83, 21.61, 22.44, 22.56, 27.87, 32.67, 42.16, 54.27, 56.80, 77.79,126.10, 127.28,128.16, 128.45, 128.57, 128.87,129.77,133.05, 137.65,138.24, 141.05,143.41, 188.55. Anal. C31H37CIN2O4S2. Cal: C, 61.93; H, 6.20; N, 4.66; S, 10.67. Found: C, 61.68; H, 6.12; N, 4.47; S, 10.67. 5.7. (r)-{l-[l-(4-CHLORO-PHENYL)-CYCLOBUTYL]-3- METHYL-BUTYLIDENE}-SULFINAMIC ACID (li?,25)-l-(2,4,6-TRIMETHYL-BENZENESULFONYL AMINCft-INDAN-2-YL ESTER (Formula Removed) The captioned compound was prepared using the same procedure as described above. The product was obtained in 75% yield. 1H NMR (CDC13): δ 0.645-0.703 (m, 6H), 1.606 (m, 1H), 1.740-1.915 (m, 2H), 2.157-2.257(m, 2H), 2.320 (s, 3H), 814.37 2.715 (s, 6H), 2.832-2.984 (m, 2H), 3.179 (dd, Jl = 4.64 Hz, J2 = 16.965 Hz, 1H), 3.359 (d, J = 16.84 Hz, 1H), 4.975 (dd, Jl = 4.85 Hz, J2 = 9.27 Hz, 1H), 5.395 (d, J = 9.03 Hz, 1H), 5.870 (m, 1H), 6.838 (d, J = 7.45 Hz, 1H), 6.992 (s, 2H), 7.08-7.15 (m, 1H), 7.18-7.23 (m, 2H), 7.308-7.405 (m, 4H). 13C NMR (CDC13): δ15.891, 21.143, 22.625, 23.328, 27.633, 31.995, 32.865, 39.093, 42.406, 56.953, 60.417, 76.335,124.126, 125.271,127.436, 128.702, 128.941, 132.215, 132.991, 135.185, 138.960, 139.126, 140.133, 141.675, 142.440, 187.856. Anal: C33H39CIN2O4S2. Cal: C, 63.19; H, 6.27; N, 4.47; S, 10.22. Found: C, 63.17; H, 6.21; N, 4.32; S, 9.86. 5.8. PREPARATION OF STEREOMERICALLY PURE IMINE PRECURSORS OF (RV and (SVDIDESMETHYLSroUTRAMINE Stereomerically pure imine precursors of (R)- and (S)-didesmethylsibutramine can be prepared as described in Scheme 8. (Scheme Removed) Scheme 8 5.8.1. PREPARATION OF (25, 4R)-5,5-DIMETHYL-4- PHENYL-3-(4-METHYL PHENYL-SULFONYL)- [1.2.3]-OXATHIAZOLIDINE-2-OXIDE To a solution of (lr)-N-(2-hydroxy-2-methyl-l-phenyl-propyl)-4-methyl-benzene sulfonamide (2.0 g, 6.3 mmol) in THF 8 mL at -45 °C was added SOCl2 (1.12 g, 9.4 mmol), followed by slow addition of pyridine (1.24 g, 12.9 mmol) in THF (8 mL) over a period of 2 h. The reaction was monitored on TLC. The reaction was quenched by addition of saturated aqueous NaHCO3 and the mixture was extracted with EtOAc (30 ml), and organic phase washed with brine (20 mL) and evaporated to dryness. The residue was added hexane (40 mL) and stirred at ambient for 2 h. The precipitate formed was filtered and wet cake washed with hexane to afford the title compound (2.0 g, 87.5%) with 99% de. 5.8.2. PREPARATION OF (R)-{l-[l-(4-CHLORO-PHENYL)- CYCLOBUTYL]-3-METHYL-BUTYLIDENE}-SULFIN- AMIC ACID (R)-l,l-DIMETHYL-2-PHENYL-2-(4- METHYLPHENYL-SULFONYLAMINO)- ETHYL ESTER The captioned compound was prepared using the same procedure as Scheme 8 for the preparation of the imine above. The product was obtained in 60% yield. 1H NMR (CDC13): δ 0.586 (d, J = 6.4Hz, 3H), 0.637 (d, J = 6.4 Hz, 3H), 1.174 (s, 3H), 1.644 (m, 1H), 1.802 (s, 3H), 1.78-1.85 (m, 2H), 2.08-2.20 9m, 2H), 2.280 (s, 3H), 2.32-2.39 (m, 1H), 2.40-2.50 (m, H), 2.74-2.88 ( m, 2H), 4.209 (d, J = 9.52, 1H), 6.034 (d, J = 9.52, 2H), 6:94-7.14 (m, 7H), 7.22-7.26 (m, 4H), 7.36-7.42 (m, 2H). ,13C NMR (CDC13): δ 15.924, 21.552, 22..701, 26.861, 26.982, 27.557, 32.056, 33.032,42.593, 56.694, 66.074, 77.339, 85.431, 126.987, 127.635, 127.885, 128.428,128.913, 129.095, 129.176, 133.040, 136.799, 137.876, 141.704, 142.727, 186.751. Analytical data: C32H39CIN2O4S2. Anal: Cal: C, 62.47; H, 6.39; N, 4.55; S, 10.42. Found: C, 62.47; H, 6.25; H, 4.39; S, 10.12. 5.9. PREPARATION OF (2S, 4R)-5,5-DIETHYL-4- PHENYL-3-(4-METHYL PHENYLSULFONYL)- [l,2,3]-OXATHIAZOLIDINE-2-OXIDE (Formula Removed) The oxathiazolidine 2-oxide was prepared from (lR)-N-(2-ethyl-2-hydroxy-l-phenyl-butyl)-4-methyl-benzenesulfonamide by following the same procedure in scheme 2, which afforded the product with 88 % yield and 99% de. *H NMR (CDC13): δ0.739 (t, J = 7.40 Hz, 3H), 0.968 (t, J = 7.42 Hz, 3H), 1.153 (h, J = 7.33 Hz, 1H), 1.588 (h, J = 7.30 Hz, 1H), 1.860 (dh, Jl = 3.05, J2 = 7.30 hz, 2H), 2.310 (s, 3H), 4.806 (s, 3H), 6.98-7.22 (m, 7H), 7.40-7.46 (m, 2H). 13C NMR (CDC13): δ7.890, 8.344, 21.692, 28.644, 29.858, 68.610,103.509, 127.779, 128.078, 128.350,129.110, 129.418, 133.420, 135.900,144.365. Anal: C19H23NO4S; Cal: C, 57.99; H, 5.89; N, 3.56; S, 16.30. Found: C, 58.10; H, 5.73; N, 3.43, S, 16.28. 5.10. PREPARATION OF (R)-{l-[l-(4-CHLORO-PHENYL)- CYCLOBUTYL]-3-METHYL-BUTYLIDENE}-SULFINAMIC ACID (lR)-2-ETHYL-l-[PHENYL-(4-METHYL PHENYL SULFONYLAMINOVMETHYL1-PROPYL ESTER The captioned compound was prepared using the same procedure as Scheme 8 for the preparation of the imine above. The compound was afforded in 90% yield. 'HNMR (CDCl3): δ0.62-0.78 (m, 9H), 1.07 (t, J =7.32Hz, 3H), 1.14-1.1.28 (m 1H), 1.33-1.47 (m, 1H),1.72 (b, 1H), 1.78-1.90 (m, 2H), 2.02-2.16 (m, 2H), 2.18-2.24 (m, 1H), 2.25 (s, 3H), 2.30-2.60 (m, 3H), 2.74-2.86 (m, 2H), 4.42 (d, J = 10. 5 Hz, 1H), 6.49 (d, J = 10.26 Hz, 1H), 6.87-6.93 (m, 2H), 6.98-7.12 (m, 4H), 7.14-7.20 (m, 2H), 7.24 (s, 3H), 7.30-7.36 (m, 2H). 13C NMR(CDC13): δ 7.692, 8.849,15.910, 21.518, 22.736, 25.669, 27.660, 27.923, 31.957, 33.054, 42.676, 56.814, 61.568, 92.458,126.880, 127.337, 127.786,128.434, 128.887,129.021, 129.708, 133.047, 136.506, 138.210, 141.754, 142.369, 187.15. Anal: C34H43CIN2O4S2; Cal: C, 63.48; H, 6.74; N, 4.35; S, 9.97. Found: C, 63.10; H, 6.76; N, 4.04, S, 9.95. 5.11. (R)-{l-[l-(4-CHLORO-PHENYL)-CYCLOBUTYL]-PENTYLIDENE}-SULFINAMIC ACID (1S, 2R) -l-PHENYL-2-(4-METHYL PHENYL SULFONYLAMINOVPROPYL ESTER (Formula Removed) The captioned compound was prepared using the same procedure as Scheme 8 for the preparation of the imine above except that n-butyl magnesium chloride was used. The compound was afforded 60 % yield. 1H NMR (CDCl3): δ 0.680 (t, J = 6.59 Hz, 3H), " 0.949-1.150 (m, 6H), 1.700 (s, 1H), 1.857-1.951 (m, 2H), 2.180-2.358 (m, 2H), 2.432 (s, 3H), 2.430-2.544 (m, 2H), 2.720-2.920 (m, 2H), 3.660-3.770 (m, 1H), 5.574 (d, J = 2.19 Hz, 1H), 5.886 (d, J = 9.28 Hz, 1H), 7.099-7.130 (m, 2H), 7.256-7.362 (m, 9H), 7.851 (d, J= 8.30 Hz, 2H). I3CNMR(CDC13): δ13.513, 15.431, 15.921,21.828,23.196,31.604, 32.041, 32.199, 33.312, 54.393, 56.780, 77.736, 126.268, 127.518, 128.388,128.615, 128.684,129.137, 129.982, 133.385, 137.869, 138.464, 141.142, 143.643,189.997. Anal: C3iH37ClN2o4S2; Cal: C, 61.93; H, 6.20; N, 4.66; S, 10.67. Found: C, 61.97, H, 6.12; N, 4.61; S, 10.30. 5.12. ASYMMETRIC SYNTHESIS OF (JgVDDMS VIA REDUCTION OF IMINE (R)-Didesmethylsibutramine can be prepared by reduction of the imine as described in Scheme 9. (Scheme Removed) Scheme 9 S.12.a. REDUCTION WITH NABH4 IN THE PRESENCE OF TITANIUM LEWIS ACID To a two necked round bottomed flask contained a magnetic stirring bar, and temperature probe and an argon outlet was charged the imine (0.1 g, 0.167 mmol, 1.0 eq), THF (3 mL) and Ti(OEt)4 (0.076 g, 2.0 eq), and the mixture was stirred at ambient temperature for 1 h. The mixture was then cooled to -45 °C and NaBEL; (0.025 g, 4.0 eq) was added. After stirred for 3 h, the reaction mixture was warmed slowly up to -10 °C - -15 °C and the reaction monitored on TLC. HCl/MeOH (4.0 mL, 4M) was added slowly to quench the reaction and the resulting mixture was stirred at r.t for 3 h. The mixture was cooled to 0°C and NaOH (5.0 M) was added to a pH >11 and diluted with EtOAc (20 mL). The organic phase was washed with brine (5 mL) and evaporated to dryness. The residue was analyzed on HPLC for yield and ee. 5.13. THE RESULTS FOR THE REDUCTION OF IMINES USING PHENYL OXATHIAZOLIDINE CHIRAL AUXILIARY Stereomerically pure imines derived from a phenyl-oxathiazolidine chirai auxiliary can be reduced to stereomerically pure didesmethylsibutramne by the reaction conditions described below. (Scheme Removed) Scheme 10 To a two necked round bottomed flask contained a magnetic stirring bar, and temperature probe and an argon outlet was charged the imine (1.0 eq), the solvent and the mixture was cooled to the reaction temperature. Then reducing reagent was added under stirring. The reaction was monitored on TLC and worked up by following the above procedure. (Table Removed) 5.13.a. SOLVENT EFFECT ON THE STEREOSELECTIVITY (Table Removed) 5.14. SYNTHESIS OF l-[l-(4-CHLORO-PHENYL)- CYCLOBUTYL1-PENTYLAMINE Stereomerically pure l-[l-(4-chloro-phenyl)-cyclobutyl]-pentylamine can be obtained from a phenyl-oxathiazolidine chiral auxiliary by the reaction conditions described below. (Scheme Removed) Scheme 11 (Table Removed) 5.15. SYNTHESIS OF (R)-DIDESMETHYLSIBUTRAMINE USING INDAN-2-YL CHIRAL AUXILIARY Stereomerically pure didesmethylsibutramine can be obtained from a stereomerically pure indan-2yl-sulfmyl chiral auxiliary by the reaction conditions described below. (Scheme & Table Removed) 5.16. SYNTHESIS OF (R)-DIDESMETHYLSIBUTRAMINE USING DIMETHYL OXATHIAZOLINDINE CHIRAL AUXILIARY Stereomerically pure didesmethylsibutramine can be obtained from a stereomerically pure dimethyl-sulfinyl chiral auxiliary by the reaction conditions described below. (Scheme Removed) Scheme 13 (Table Removed) 5.17. SYNTHESIS OF (R)-DIDESMETHYLSIBUTRAMINE USING DIETHYL OXATHIAZOLINDINE CHIRAL AUXILIARY Scheme 14 52 Stereomerically pure didesmethylsibutramine can be obtained from a stereomerically pure diethyl-sulfmyl chiral auxiliary by the reaction conditions described below. (Scheme & Table Removed) 5.18. ONE POT PROCEDURE FOR THE ASYMMETRIC SYNTHESIS OF (Jg)-PDMS-D-TA The one-pot asymmetric synthesis of stereomerically pure D-tartaric acid salt of (R)-didesmethylsibutramine is described below. (Scheme Removed) Scheme 15 To a 100 mL three-necked flask equipped with a magnetic stir bar, an argon inlet, a thermometer probe and rubber septum, was charged l-(4-chloro-phenyl)-cyclobutanecarbonitrile (CCBC) (8.0 g, 41.9 mmol (96%)) and CuBr (0.12 g, 2%). After purging the flask with argon for 10 min, MTBE (15 mL) and iBuMgCl (68 mL, 0.61 mol in MTBE) were added and the reaction mixture was refluxed for 4 -6 h. The reaction was monitored on HPLC for the disappearance of CCBC. The reaction mixture was cooled to ambient temperature and added drop-wise to the solution of (25,4R, 5S)-4-methyl-5-phenyl-3~(4-methyl phenyl-sulfonyl)-[l,2,3]-oxathiazolidine- 2-oxide (15.0 g, 42 mmol) in THF (100 mL) in a 500 mL round-bottomed flask at -78 °C. The reaction mixture was stirred for 4 h and warmed up to 10 °C under stirring. The reaction was monitored on TLC for the disappearance of l-[l-(4-chloro-phenyl)-cyclobutyl]-3-memyl-butylideneamine. Then the reaction mixture was cooled to 0 °C and aqueous ammonium acetate (30%, 50 mL) was added, follows by MTBE (200 mL) and warmed up to ambient temperature. The organic phase was washed with 30% KHC03 (50 mL) and 20% TSIaCl (50 mL) and polish filtered through two layers of filter paper. After the resulting organic phase was distilled under reduced pressure to about 50 mL (KF = 0.58 %), anhydrous THF (80 mL) and Ti(OPri)4 were added and the mixture was stirred at ambient temperature for 1 h and cooled to -45 °C. NaBH4 (6.4 g, 168 mmol) was added in one portion and the mixture was stirred for 6 h and warmed up to -20 °C and the reaction was monitored on TLC for the disappearance of starting material. To the reaction mixture was slowly added aqueous HC1 dissolved in MeOH (60 mL, 4M) and the mixture was warmed to ambient temperature and stirred for 3h. After the mixture was cooled to 0 °C, NaOH (5 M) was added slowly to pH -12 for the solution, the mixture was diluted with toluene (200 mL), and was distilled under reduced pressure to remove the low boiling point solvents. The organic phases were allowed to separate for 20 min and the organic phase was washed twice with aqueous NaCl (50 mL, 20%). The mixture was heated to 60-70 °C and D-tartaric acid (6.3 g) in water (13 ml) and acetone (6 mL) was added slowly. The mixture was distilled under azeotropic condition until the internal temperature reached >95 °C. The mixture was then cooled to ambient temperature and stirred for 1 h. The slurry formed was filtered and the wet cake was washed with toluene (30 mL x 2) and MTBE (30 mL) and dried at 45 °C for 24 h under reduced pressure to afford the (R)-DDMS.D-TA with 85% yield and 70% ee. 5.18.a. RECOVERY OF (1S,2R)-NOREPHEDRINE N-TOSYLATE The above mother liquor was vacuum distilled to about 60 mL and water (50 mL) was added. The resulting mixture was distilled until all the internal temperature reached to -100 °C and mixture was stirred. Heptane (40 mL) was added and the mixture was stirred to ambient temperature while a nice slurry was formed. The slurry was filtered and the wet cake was washed with water (20 mL) and heptane (30 mL) and dried at 45 °C under reduced pressure to afford 12.5 g (1S,2R)-norephedrine N-tosylate (89.5%). 5.19 PREPARATION OF SULFOXIDE AND SULFONYLAMINE STEREOISOMERS Tert-Butylsulfonylquinine (TBSOQ) was isolated in 92% yield, and great than 99% d.e. when (-)-Quinine was used as the chiral auxiliary, and tert-butylmagnesium chloride was used as the first nucleophile (R'IVI). Displacement of the auxiliary with a second nucleophile (R2M)such as alkyl Grignard reagent, or Aryl diethylaluminium provided the enantiomeric enriched sulfoxides. When TBSOQ was treated with amide anions such as lithium amide in liquid ammonia or lithium bis(trimethylsily)amide in solvent such as THF, afforded the enantiomeric enriched sulfinylamides. (Formula Removed) Table 1. Preparation of TBSOQ (Table Removed) Table: Nucleophilic dispacement of TBSOQ to form sulfoxide or sulflnylamine (Scheme & Table Removed) Scheme 16 (Formula Removed) Novel Practical Process for Preparation of Enantiopure Sulfinylamines Supporting Information General. Unless otherwise noted, all reagents were obtained from commercial suppliers and were used without further purification. All anhydrous solvents were used for the reaction, and were purchased from Aldrich. All reactions, unless otherwise noted, were carried out in oven dried glassware under inert argon atmosphere. Chromatography was carried out using Silicycle 60, 230-400 mesh silica gel. Thin-layer chromatography (TLC) analysis was performed with Merk Kieselgel 60 F 254 plates, and was visualized using UV light and/or phosphomolybdic staining. lB. NMR and proton-decoupled 13C NMR spectra were obtained with a Varian Inova 300 spectrometer in CDCl3 with TMS as an internal standard at room temperature. Proton and carbon spectra chemical shifts were reported using TMS and/or CDCl3 as an internal standard at 0 ppm and at 77.23 ppm, respectively. Diastereomeric ratios were determined on XB. NMR spectrum analyses. Elemental analyses were performed by Quantitative Technologies, Inc., Whitehouse, NJ. Enantiomeric excesses were obtained by chiral HPLC analysis using Chiralpak AS, Chiralcel OB, or Chiralcel OD column. Preparation of TBSOQ: (Formula Removed) A 4-neck 1 L round-bottom flask fitted with a mechanical stirrer, addition funnel, temperature probe, and argon inlet was charged with (-)-quinine (3.0 g, 9.25 mmol, 1.0 equiv.) and THF (80 mL). The solution was chilled to -60 °C, thionyl chloride (0.75 mL, 10.28 mmol, 1.1 equiv.) was added dropwise via a syringe. The mixture was stirred for 10 min, followed by addition of Et3N (2.9 mL, 20.85 mmol, 2.2 equiv.) over a 5 min period. The resultant mixture was stirred at between -37 ~ -45 °C for 1 hr, followed by addition of tert-butyl magnesium chloride (19 mL, 1.0 M in THF, 19.0 mmol, 2.05 equiv.) at -78 °C. The resultant clear reaction was stirred at -75 °C for 2 h and monitored by TLC analysis. Once the reaction was completed, the reaction was quenched with saturated NaHCC>3 aqueous solution (90 mL), and the mixture was diluted with ethyl acetate (150 mL) and warmed to ambient temperature with stirring. The phases were allowed to separate and the aqueous phase was removed. The aqueous phase was extracted with ethyl acetate (100 mL). The combined organic phases were washed with brine (60 mL), dried, and evaporated to give diastereopure TBSOQ. The yellowish oily product was purified by flash column chromatography (eluent with 5% MeOH in AcOEt) to remove impurities derived from the starring material, and give pure TBSOQ as colorless oil which turned into white solid after standing at ambient temperature (3.6 g, 91% yield). The diastereomeric excess is >99% as determined by 1H NMR spectrum and HPLC. 1HNMR(CDC13)δ 13CNMR(CDC13)δ. HPLC method: Symmetry CMS, 4.6mm x 150 mm, 5 p; 222 nm; 0.5 mL/min.; MeOH/H20 80:20. (S)-tert-Butyl phenylsulfoxide: (Formula Removed) A solution of TBSOQ (1.79 g, 4.14 mmol, 1.0 equiv.) in THF (20 mL) at -78 °C under argon was charged dropwise with phenylmagnesium bromide (2.8 mL, 3.0 M in Et20, 8.3 mmol, 2.0 equiv.). After being stirred at -78 °C for 1 h, the reaction mixture was warmed to 22 °C, and the reaction was monitored by TLC analysis. The reaction was quenched by 20% NaCl (15 mL) aqueous solution and diluted with EtOAc (30 mL). After phase separation, the organic phase was extracted once with EtOAc. The combined organic phases was washed with 20%) NaCl (10 mL) aqueous solution, dried over Na2S04, and concentrated to give the mixture of (S)-tert-Butyl phenylsulfoxide and (-)-quinine, which was purified by flash chromatography eluted with EtOAc to afford (S)-f-butyl isobutyllsulfoxide (0.76g, 93%) in >99% ee. The enantiomeric purity was analyzed by chiral HPLC analysis. The configuration at sulfur atom was deduced by comparison of the optical rotation with that of reported in literature. *H NMR (300 MHz, CDC13): δ 1.20 (s, 9H), 7.53 (m, 3H), 7.63 (m, 3H). 13C NMR (75 MHz, CDCl3): δ23.0, 56.0, 126.6, 128.6, 131.4, 140.2. [a]22D = -184 (c, 0.84, CHCI3); Lit.2 +175. (R)-tert-Butyl (tert-butylsulfinyl)acetate (R2 = LiCH2COOBu-0: (Formula Removed) A solution of diisopropylarnine (0.3 mL, 2.14 mmol) in THF (4 mL) at -15 °C was added n-BuLi (1.3 mL, 1.6 M in hexane, 2.08 mmol) slowly. The mixture was warmed to 0 °C, stirred for 30 min and cooled to -45 °C, followed by addition of ter/-butyl acetate (0.28 mL 2.08 mmol, 1.0 eq). The reaction mixture was stirred for 30min and was cooled to -78 °C. A solution of TBSOQ (300 mg, 0.70 mmol) in THF (2 mL) was added slowly while keeping the reaction mixture at -78 °C—75 °C and the reaction was monitored by TLC analysis. The reaction was worked up and the crude product was purified by flash chromatography eluted with EtOAc-MeOH (5:1) to afforded the title compound (133~mg) in a 81% yield and >99% ee. lH NMR (CDC13): δ 1.28 (s, 9H), 1.51 (s, 9H), 3.29 (d, 1H), 3.47 (d, 1H). 13C NMR (CDCl3): δ 22.7, 27.9, 52.8, 54.0, 83.1, 1654. Chiral HPLC method: Chiralpak AS 4.6mm x 250 mm, 10 \x; 222 nm; 0.8 mL/min.; Hex/EtOH 90:10; («S)-isomer, tR = 11.2 min; (^)-isomer tR = 13.2 min. (99.8% ee). (Formula Removed) p-Tolylmagnesium bromide (15 mL, 1.0 M in THF, 15 mmol, 2.1 equiv.) was added to a solution of diethylaluminium chloride (8.3 mL, 1.8 M in toluene, 15 mmol, 2.1 equiv.) at -60 °C to -50 °C. The mixture was then cooled to -78 °C and stirred for 0.5 hr. In another 3-neck 250 mL round-bottom flask fitted with addition funnel, temperature probe, and argon inlet was charged with (-)-quinine (2.27 g, 7.0 mmol, 1.0 equiv.) and THF (48 mL). The solution was chilled to -75 °C, thionyl chloride (0.54 mL, 7.40 mmol, 1.05 equiv.) was added dropwise via a syringe. The mixture was stirred for 10 min, followed by addition of Et3N (2.14 mL, 15.4 mmol, 2.2 equiv.) over a 5 min period. The resultant mixture was stirred for 30 min, followed by addition of the above-mentioned p-tolyl diethylaluminium at the same temperature. The resultant clear reaction was stirred at -75 °C for 2 h and monitored by TLC analysis. The reaction was then quenched with saturated aqueous solution of Rochelle's salt and extracted with ethyl acetate (2 x 25 mL). The organic extracts were washed with brine and evaporated. The residue was purified by flash chromatography eluted with 5% methanol in EtOAc to afford p-tolylquininyl sulfoxide ester (2.5 g) in 78% yield. (Formula Removed) Methyl magnesium chloride (100 uL, 3.0 M in THF, 0.3 mmol, 1.4 equiv) was added to a solution of the p-tolylquininyl sulfoxide ester (100 mg, 0.216 mmol) in THF (2 mL) at -60 °C to -78 °C. The reaction mixture was then stirred at -78 °C for 30 min and the reaction was monitored by TLC analysis. The reaction was then quenched with saturated KHCO3 aqueous solution and extracted with ethyl acetate (2x10 mL). The organic extracts were washed with brine and evaporated. The residue was purified by flash chromatography eluted with EtOAc to afford the title compound (30 mg) in 88% yield. The diastereomeric excess is >99% as determined by HPLC. The absolute configuration is deduced from comparison with authentic sample. Chiral HPLC method: Chiralpak AS, 90:10 Hex/EtOH, 1 min/mL The present invention is i ot to be limited in scope by the specific embodiments disclosed in the examples which are intended as illustrations of a few aspects of the invention and any embodimenls which are functionally equivalent are within the scope of this invention. Indeed, various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art and are intended to fall within the appended claims. We claim: 1. A method of preparing an amine stereoisomer, which comprises: (a) forming a sulfinylamine stereoisomer by stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, followed by; (b) contacting the sulfinylamine stereoisomer with a reagent such as herein described suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer. 2. A method as claimed in Claim 1, wherein the residue of the alcohol, thiol or amine is in stereoisomeric form. 3. A method as claimed in Claim 1 or 2, wherein the residue of the alcohol, thiol or amine is a residue of an optionally N-substituted beta-amino alcohol, thiol or amine. 4. A method as claimed in Claim 3, wherein the optionally N-substituted beta-amino alcohol, thiol or amine is a compound of the general formula (Formula Removed) wherein A1' is R7HN or (R7-)R-7"N, R7 represents hydrogen or -L-R7n in which -L-repieseuts a bond, -CO-, -(CO)O-, -(CO)NR7b , SO , SO? , or (SO2)0-, each of R73 and R7b independently represents substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, and R7' and R7" are as defined for R7a, or Rr and R7" together with the nitrogen atom to which they are attached and, optionally Rs, form an unsubstituted or substituted heterocyclic group, or R7- together with the nitrogen atom to which it is attached and the carbon atom to which the nitrogen atom is attached forms an unsubstituted or substituted heterocyclic group; A2 is O, S or NR7C in which R7c is substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and each of R8, R9, R10 and R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubsututcd aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubsututed aryl or substituted or unsubstituted heteroaryl, or R8 and R11 together form a substituted or unsubstituted alkylene or heteroalkylene chain. A method as claimed in Claim 4, wherein A2 is O. A method as claimed in Claim 4 or Claim 5, wherein each of R8 R9, R10 and R11 is independently selected from hydrogen, (1-4C) alkyl and phenyl, or the alcohol is selected from (N-methylpyrrolidin-2-yl) diphenylmethanol, quinine, quinidine, hydroquinine, cinchonidine, cinchonine, hydrocinchonidine and ethyl hydrocupreine. A method as claimed in Claim 6, wherein Ar is (Rz)HN wherein R7 represents -SO2-R77a in which R7a represents (l-6C)alkyl, (6-10C)aryl (l-4C)alkyl or (6-l()C)aryl in which any aryl group is unsubstituted or substituted by one, two or three substituents selected independently from halogen, (l-4C)alkyl and (l-4C)alkoxy, or Ar is(R/')R7"N wherein R7 and R7a each independently represents a (1 4C)alkyl group or together with the nitrogen to which they are attached represent a pyrrolidine group that may bear one or two methyl substituents, or the alcohol is selected from (N-methylpyrrolidin-2-yl) diphenylmethanol, quinine, quinidine, hydroquinine, cinchonidine, cinchonine, hydrocinchonidine and ethyl hydrocupreine. A method as claimed in Claim 6, wherein Ar is (R?)HN and the residue of the alcohol, thiol or amine is a residue of an optionally N-substitutcd 2-ammo-l- phenylpropanol, 2-amino-2-methyl-1 -phenylpropanol, 1 -amino-1 -pheny 1-2- propanol, l-amino-l-phenyl-2-methyl-2- propanol, l-amino-l-phenyl-2-ethyl-2- butanol, l-amino-2-indanol, 2-aminoindan-l-ol, lamino-2-hydroxy-l,2, 3,4- telrahydronaphthalene or 2-amino-l-hydroxy-1,2,3,4-tetrahydronaphthalene, or Ar is (R7-)R7"N and the alcohol is selected from 2-N,N-dimethylamino-l-phcnyl- 2-propanol, 2-N,N-dibutylamino-1 -phenylpropanol, 2-pyrrolidin-1 -yl-1 - phenylpropanol, 2-(2-methylpyrrolidin-l-yl)-l-phenylpropanol, 2-(2,5- dimethylpyrrolidinyI-l-yl)-l-phenylpropanol, 2-N,N-dimethylamino-2-methyl-l-phenylpropanol, (N-methylpyrrohdin-2-yl)diphenylmcthanol, l-pyrrolid)ovl- ylindan-2-ol, 3~benzyloxy-2-N,N-dimethylamino-l-phenylpropan 2-ol, quinine, quinidine, hydroquinine, cinchonidine, cinchonine, hydrocinchonidine and ethyl hydrocupreine. 9. A method as claimed in any one of Claims 3 to 8, wherein prior to step (a) of claim 1, optionally the sulfinylirmne has been obtained by contacting an iminometal with a 1,2,3-oxathiazolidine-S-oxide, a 1,2,3-dithiazolidine-S-oxide or a 1,2,3-azathiazolidine-S-oxide, wherein preferably: the iminometal is a compound of formula 1' (Formula Removed) wherein M is CdZ, BaZ, Na, K, MgZ, ZnZ, Li, MnZ, CuZ, TiZ3 or In and Z is an anion; the 1,2,3-oxathiazolidine-S-oxidc, a 1,2,3-dithiazolidinc-S-oxide or a 1,2,3- azathiazolidine-S-oxide is a compound of formula 3 or 3' (Formula Removed) wherein A1 is R7N or (R7")R7" N+Q- in which Q- is an anion, R7 represents hydrogen or -L-R7a in which -L- represents a bond, -CO-, -(CO)O-, -(CO)NR7b-,-SO-, -SO2-, or -(SO2)O-, each of R7a, and R7b independently represents subsututed or unsubstituted alkyl, subsututed or unsubsUtuted aralkyl, subsututed or unsubstituted heteroalkyl, subsututed or unsubsUtuted aryl or subsututed or unsubstituted heteroaryl, and R7" and R7" are as defined for R7a, or R7 and R7" together with the nitrogen atom to which they are attached and, opuonally RH, form an unsubsUtuted or substituted heterocyclic group, or R7a together with the nitrogen atom to which it is attached and the carbon atom to which the nitrogen atom is attached forms an unsubstituted or substituted heterocyclic group, A> is O, S or NR7C in which R/c is substituted or unsubstituted alkvl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and each of RK, R% R10 and R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or R8 and R11 together form a substituted or unsubstituted alkylene or heteroalkylene chain; and more preferably a 1,2,3-oxathiazolidine-S-oxide, a 1,2,3-dithiazolidine-S-oxide or a 1,2,3-azathiazolidine-S-oxide is a stereoisomer of formula: (Formula Removed) more preferably wherein the 1,2,3-oxathiazolidine-S-oxidc, 1,2,3-dithiazolidine-S-oxide or 1,2,3-azathiazolidine-S oxide has been prepared by reacting an optionally N-substituted beta-amino alcohol, thiol or amine with a thionyl halide. A method as claimed in Claim 1 and 9, wherein the amine stereoisomer is a compound of formula 5 or 5' (Formula Removed) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or prodrug thereof, wherein R5 and R6 are independently substituted or unsubstituted-alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or R5 and R6 together with the carbon atom to which they are attached form a substituted or unsubstituted cycloalkyl group, and R1 , and R13 togethet with the nitrogen atom to which they are attached form a heterocycle, or each of Rr and R13 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl; and the sulfinylaminc stereoisomer is a compound of formula 4 or 4' (Formula Removed) wherein Ay represents (R/)HN or (R/>)RrN. 11. A method as claimed in Claim 10, wherein A2 is O. 12. A method as claimed in Claim 9 to 11, wherein Rs and R6 are independently substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and in the 1,2,3-oxalhiazolidinc-S-oxidc of the formula 3 or 3' R7 represents hydrogen or -J,-R7a in which L is a bond or SO, and R7a is substituted or unsubstituted alkyl, substituted or unsubstituted afalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and Z in the iminometal of formula 1' is CI, Br or I; and the sulfinylamine stereoisomer is a compound of formula (Formula Removed) 13. A method as claimed in any of Claims 10 to 12, wherein R12 and R13 are both hydrogen. 14. A method as claimed in any one of Claims 1 to 13, wherein the amine stereoisomer is a compound of formula (Formula Removed) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or prodrug thereof, wherein Ru is substituted or unsubsututed alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubsututed aralkyl or substituted or unsubstituted aryl, and Rr, and Rio together with the nitrogen to which they are attached form a heterocycle, or each of R15 and R16 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubsututed heteroalkyl, subsututed or unsubstituted aralkyl or substituted or unsubsututed aryl. A method as claimed in Claim 14, in which the amine stereoisomer is 15. a compound of formula (Formula Removed) 16. A method as claimed in Claim 14 or Claim 15, wherein R15 and R10 are both hydrogen. 17 A method as claimed in any one of Claims 9 to 16, wherein the 1,2,3- oxathiazolidine-S-oxide is a compound of the formula (Formula Removed) A method as claimed in any one of Claims 1 to 18, wherein the sulfinylimine is reduced using a hydride reducing agent, preferably NaBH4. A method as claimed in any one of Claims 1 to 19, in which the reagent suitable for the cleavage of a sulfur-nitrogen bond is an acid, preferably HC1. A method as claimed in any one of Claims 3 to 20, in which reaction of the sulfinylamine stereoisomer with the reagent suitable for the cleavage of a sulfur-nitrogen bond also affords an optionally N-substitutcd beta-aminoalcohol, and this optionally Nsubstituted beta-aminoalcohol is recovered, converted into 1,2,3-oxathiazolidine-S-oxide and recycled. A method as claimed in any one of Claims 1 to 20, wherein said source of -a nucleophile is selected from a nitnle, a Gngnard reagent and an organolithium. A method as claimed in Claim 21, wherein the sulfinylamine stereoisomer is reacted with a mtrile, and the resultant amine stereoisomer bearing a nitrile group is optionally hydrolyzed to afford an amino acid. A method as claimed in claim 1 wherein said sulfinylamine stereoisomer is of the formula (Formula Removed) wherein: R5 and R6 are independently substituted or unsubstitutcd alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubsiituted aralkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, or R, and R6 together with the carbon atom to which they are attached form a substituted or unsubstituted cycloalkyl group; A1' is (R7)HN or (R7-)R7"N; R7 represents hydrogen or -L-R7a in which -L- represents a bond, -CO-, -(CO)O-. -(CO)NR7b-. -SO-, -SO2-, or ~(SO2)O-. each of R7a and R7b independently represents substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstitutcd aryl or substituted or unsubstituted heferoaryl, and R? and R7 • are as defined for R7a. or R?' and R7a together with the nitrogen atom to which they are attached and. optionally R», form an unsubstituted or substituted heterocyclic group, or R7 together with the nitrogen atom to which it is attached and the carbon atom to which the nitrogen atom is attached forms an unsubstituted or substituted heterocyclic group; A2 is O, S ot NR4a in which R7a is substituted or unsubstituted alkyl. substituted or unsubstituted aralkyl. substituted or unsubstituted heteroalkyl. substituted or unsubstituted aryl or substituted or unsubstitutcd hcteroaryl; and each of R8 R9, R10and R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstitutcd aralkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or substituted or unsubstitutcd heteroaiyl. or R8 and Ri 1 together form a substituted or unsubstituted aikylenc or hctcroalkylcnc chain; 24. A method as claimed in Claim 23, wherein AT is O. 25. A method as claimed in any one of Claims 23 or 24, wherein Ar represents (R7)HN and R7 represents R7.,SO:> in which R/a represents a (1-6C) alkyl, (6-lOQaryl (l-6C)alkyl or (6-10C)aryl group, in which the aryl group is unsubstituted or substituted by one, two or three substituenis selected independently from a halogen atom, a (l-4C)alkyl group and a (1- 4C)alkoxy group, or Ar represents (R7-)R.7"N in which Ry and Rv each independently represents a (1-4C) alkyl group or together with the nitrogen to which they are attached represent a pyrrolidine group that may bear one or two methyl substituents, and each of R8, R9, R10 and R11 is independently selected from hydrogen, (1-4C) alkyl and phenyl, or the group (Formula Removed) is selected from a residue of (N-mcthyIpyrrolidin-2-yl)diphenylmethan(>l, l-pyrrolidin-1-ylindan-2-ol, 3-bcnzyloxy-2-N,N-dimethylamino-l-phenylpropan-2-ol, quinine, quinidinc, hydroquinine, cinchonidine, cirtchonmc. hydrocinchonidine and ethyl hydrocuprcinc. 26. A method as claimed in any of claims 15 and 25 to 28, wherein said sulfinyl stereoisomer is of the formula (Formula Removed) 27. A method as claimed in any of claims 23 to 26 wherein wherein Ar represents (R7)SO2N in which R7 represents a (l-6C)alkyl, (6-10C)aryl(l-6C)alkyl or (6-lOQaryl group, in which the aryl group is unsubstituted or substituted by one, two or three substituents selected independently from a halogen atom, a (1-4C) alkyl group and a (1-4C) alkoxy group; or the group (Formula Removed) is a residue of 2-N, N-dimethylamino-1-phenylpropanol, 2-N, N-dibutylamino-1-phenylpropanol,2-pyrrolidin-l-yl-l-phenylpropanol, 2-(2-methylpyrrolidin-l-yl)-lphenylpropanol, 2-(2,5-dimethylpyrrolidin-l-yl)-l phenylpropanol, 2-N, N- dimethylamino-2-methyl 1-phenylpropanol, (N-methylpyrrohdin-2-yl) diphenylmethanol,l-pyrrolidin-l- ylindan-2-ol, 3-benzyloxy-2-N, N- dimethylamino-l-phenylpropan-2-ol, quinine, quinidine, hydroquinine, cinchomdine, cinchomne, hydrocinchonidine or ethyl hydrocupreine.

Documents:

2806-delnp-2004-abstract-(23-05-2008).pdf

2806-delnp-2004-abstract-(23-12-2008).pdf

2806-delnp-2004-abstract.pdf

2806-delnp-2004-assignments.pdf

2806-delnp-2004-claims-(23-05-2008).pdf

2806-delnp-2004-claims-(23-12-2008).pdf

2806-delnp-2004-claims.pdf

2806-delnp-2004-complete specification(granted).pdf

2806-DELNP-2004-Correspondence-Others-(19-09-2008).pdf

2806-DELNP-2004-Correspondence-Others-(23-05-2008).pdf

2806-delnp-2004-correspondence-others.pdf

2806-delnp-2004-description (complete)-(23-12-2008).pdf

2806-delnp-2004-description (complete).pdf

2806-delnp-2004-description (complete)23-05-2008.pdf

2806-delnp-2004-form-1.pdf

2806-delnp-2004-form-13.pdf

2806-delnp-2004-form-18.pdf

2806-delnp-2004-form-2-(23-05-2008).pdf

2806-delnp-2004-form-2.pdf

2806-delnp-2004-form-26.pdf

2806-delnp-2004-form-3.pdf

2806-delnp-2004-form-5.pdf

2806-delnp-2004-pct-101.pdf

2806-delnp-2004-pct-210.pdf

2806-delnp-2004-pct-304.pdf

2806-DELNP-2004-Petition-137-(23-05-2008).pdf