| Title of Invention | A PDE IV INHIBITING PYRIDINE COMPOUND |
|---|---|
| Abstract | The present invention concerns pyridine derivatives having formula(I), the pharmaceutically acceptable addition salts and the stereochemically isomeric from thereof wherein L is hydrogen; C1-6alkyl; C1-6 alkyl carbonyl; C1-6alkyloxycarbonyl; substituted C1-6alkyl; C3-6alkenyl; substituted C3-6alkenyl; piperidyl; C1-6alkylsulfonyl or arylsulfonyl;-A-B-is-CR4=CR5-or-CHR4-CHR5-; D is O or NR6 is a hydrogen or C1-4alkyl; R2 is hydrogen; halo; c1-6alkyl; trifluoromethyl; or NH-R10; R3 is hydrogen halo, hydroxyl, C1-6 alkyl or C1-6alkyl or R2 and R1, or R2 and R3 taken together may form a bivalent radical; Q is disubstituted pyridine, R7 and R8 each independently are hydrogen; C1-6alkyl; difluoromethyl; trifluoromethyl; C3-6cyclo alkyl; a saturated 5-, 6- or 7-membered heterocycle containing one or two heteroatoms selected from oxygen, sulfur or nitrogen; indanyl; 6,7-dihydro-5h-cyclopentapyridyl; bicycle[2.2.1]-2-heptenyl; bicycle C1-6alkylsulfonyl; arylsulfonyl; or substituted C1-10alkyl; having PDE IV and cytokine inhibiting activity. The invention also relates to process for preparing the compounds of formula (I), pharmaceutical compositions thereof and their use as a medicament. |
| Full Text | N/A |
|---|
in-pct-2000-00287-mum-abstract(24-09-2008).pdf
in-pct-2000-00287-mum-cancelled pages(24-09-2008).pdf
in-pct-2000-00287-mum-claims(granted)-(24-09-2008).pdf
in-pct-2000-00287-mum-correspondence(24-09-2008).pdf
in-pct-2000-00287-mum-correspondence(ipo)-(16-01-2009).pdf
in-pct-2000-00287-mum-form 1(24-09-2008).pdf
in-pct-2000-00287-mum-form 13(24-09-2008).pdf
in-pct-2000-00287-mum-form 18(29-12-2005).pdf
in-pct-2000-00287-mum-form 2(granted)-(24-09-2008).pdf
in-pct-2000-00287-mum-form 3(10-08-2000).pdf
in-pct-2000-00287-mum-form 3(24-09-2008).pdf
in-pct-2000-00287-mum-form 5(10-08-2000).pdf
in-pct-2000-00287-mum-form-pct-ipea-409(10-08-2000).pdf
in-pct-2000-00287-mum-form-pct-isa-210(10-08-2000).pdf
in-pct-2000-00287-mum-petition under rule 137(24-09-2008).pdf
in-pct-2000-00287-mum-petition under rule 138(24-09-2008).pdf
in-pct-2000-00287-mum-power of authority(07-12-2000).pdf
in-pct-2000-00287-mum-power of authority(24-09-2008).pdf
IN-PCT-2000-287-MUM-ABSTRACT(24-9-2008).pdf
IN-PCT-2000-287-MUM-CANCELLED PAGES(24-9-2008).pdf
IN-PCT-2000-287-MUM-CLAIMS(24-9-2008).pdf
IN-PCT-2000-287-MUM-CORRESPONDENCE(24-9-2008).pdf
IN-PCT-2000-287-MUM-DESCRIPTION(COMPLETE)-(24-9-2008).pdf
IN-PCT-2000-287-MUM-FORM 1(24-9-2008).pdf
in-pct-2000-287-mum-form 2(24-9-2008).pdf
IN-PCT-2000-287-MUM-FORM 2(TITLE PAGE)-(24-9-2008).pdf
IN-PCT-2000-287-MUM-FORM 3(24-9-2008).pdf
IN-PCT-2000-287-MUM-FORM 5(24-9-2008).pdf
IN-PCT-2000-287-MUM-MARKED COPY(24-9-2008).pdf
IN-PCT-2000-287-MUM-OTHER DOCUMENT(24-9-2008).pdf
IN-PCT-2000-287-MUM-PCT-IB-304(24-9-2008).pdf
IN-PCT-2000-287-MUM-PETITION UNDER RULE 137(24-9-2008).pdf
IN-PCT-2000-287-MUM-PETITION UNDER RULE 138(24-9-2008).pdf
IN-PCT-2000-287-MUM-POWER OF AUTHORITY(24-9-2008).pdf
| Patent Number | 227702 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indian Patent Application Number | IN/PCT/2000/00287/MUM | |||||||||||||||
| PG Journal Number | 10/2009 | |||||||||||||||
| Publication Date | 06-Mar-2009 | |||||||||||||||
| Grant Date | 16-Jan-2009 | |||||||||||||||
| Date of Filing | 10-Aug-2000 | |||||||||||||||
| Name of Patentee | JANSSEN PHARMACEUTICA N.V. | |||||||||||||||
| Applicant Address | TURNHOUTSEWEG 30, BEERSE, B-2340 | |||||||||||||||
Inventors:
|
||||||||||||||||
| PCT International Classification Number | C07D401/06 A61K31/44 | |||||||||||||||
| PCT International Application Number | PCT/EP99/02045 | |||||||||||||||
| PCT International Filing date | 1999-03-24 | |||||||||||||||
PCT Conventions:
|
||||||||||||||||