Title of Invention

BIOCIDAL CLEANING COMPOSITION

Abstract "BIOCIDAL CLEANING COMPOSITION" The present invention relates to a biocidal cleaning composition comprising a biocide, a surfactant of formula R-0-(G)n, an amphoteric surfactant and an anionic surfactant. £6 MAY 2008
Full Text FORM 2
THE PATENTS ACT 1970
[39 OF 1970]
COMPLETE SPECIFICATION
[See Section 10 and rule 13]
"BIOCIDAL CLEANING COMPOSITION"
SELDEN RESEARCH LTD, a British company of Ashbourne Road, Buxton, Derbyshire SK I7 9RZ, United Kingdom,
The following specification particularly describes the nature of the invention and the manner in which it is to be performed:-

Biocidal cleaninq composition
The invention relates to biocidal cleaning compositions and more particularly but not exclusively to mild liquid formulations having utility in the manuaf cleaning and sanitising of dishes and hard surfaces.
There exists a continuing need for mild surfactants suitable
particularly for manual dishwashing and other light duty hard surface
. cleaning applications, and such products have been the subjects of much
prior art.
These products have generally comprised anionic and non-ionic surfactant-blends conferring on them good foaming and drain drying properties so that crockery and glassware are rendered sparkling clean and streak free.
, Furthermore, since the world's population is now more hygiene conscious than ever before it is desirable to produce a composition; which in addition to cleaning properties, also possesses antibacterial properties, and. as such is suitable for sanitising hard surfaces, floors,, walls work surfaces and the like, especially in catering, food processing and health and hygiene situations where major.health problems can arise due to the growth and spread of pathogenic bacteria.
These products have generally combined non-tonic surfactants with cationic biocides and/or organic halides often with higher alcohol co-solvents and chelating agents. They tend to be characterised by having

relatively low foam and whilst they may have good grease removal, they are unsuitable for use in manual dishwashing applications as" crockery "and glassware are left with residual streaks and smears.
Previous attempts, to combine both dishwashing and sanitising have met with limited success due to the incompatibility of anionic surfactants .. withcationic biocides such that their biocidal effectiveness has been much reduced. The use of organic halides or other biocides 'compatible with anionic surfactants has had limited success due to. their ineffectiveness at high diiutions Recent attempts to overcome these constraints have resulted in. formulations having good dishwashing properties at normal use dilutions with biocidal properties When used neat or virtually neat.
Certain groups of non-ionic surfactants particularly those based on sugars and vegetable oils for example alkyl poiyglycbsides (also known as alkyl"p6Iygfu.cpsides and hereinaftef referred to as APG's) are fhild to the skin and have good foaming arid rinsing properties. Moreover their ,■ detergericy may be potentiated by combination with amphoteric surfactants. • It is also known that they are compatible with some catibnic surfactants. ■This has been utilised in the formulation of for example mouthwashes and skin and hair cleansers.
International Patent Application Nos. 94/05753 95/31962 nd European Patent Application No, 0911022A1 all teach of the use of APG's' in such compositions.

APG'S have also been used as additives in manual dishwashing formulations to confer mildness usually in conjunction with anionic surfactants such as alkyl benzene sulphonate or sodium lauryl sulfate. The use of cationic biocides or biguanides in mouthwashes and skin cleansers and for example, surgical scrubs are also well known in the prior art and is described in US Patents Nos. 4022834 and 5719113.
However, the combination . of sugar surfactants, amphoteric ■surfactants and quaternary biocides, or biguanides has hot been previously applied to the production of a dishwashing composition having effective biocidal properties, at normal use dilution.
Therefore, an object of the present invejition is. to provide a high performance surfactant solution with superior manual dish and glasswashing properties which also exhibits biocidal properties effective at normal use dilutions and is suitable for light duty hard surface cleaning/sanitising applications.
According to the present invention therefore, there is provided a biocidal cleaning composition comprising a biocide, a surfactant of formula 1 and an amphoteric surfactant.

Formula I
R-0-(G}n wherein; R = alkyl (C4 - C24),
G = saccharide residue having 5 or 6 Carbon atoms,
n = a number from 0,4 to 10.
In a preferred embodiment of the invention the biocide is water
soluble, typically^ has some cationic properties and is normally either a
biguanide or a quaternary ammonium compound. Suitable biguanides are
.. referred to.-.in US; .patentiiNos. 3,468,898 : and. 4,022,834 and are
preferentially either a salt of chlorhexidine or polyhexamethylene biguanide (PHMB}, as exemplified in formula II. ChJbmexidine is the common name for the antiseptic 1,1/-hexamethyJene-bis-[-5-(4-chrofophenyl)-biguanide].
Formula II

wherein; HX is a salt forming anion
n is a No. between 4 and 50, but preferably 12. Suitable quaternary ammonium biocides are of formula 111.


Where R1 is selected from an alkyl group having 6 to 24 carbon atoms or aromatic, aryl or alkaryl groups having 6 to 24 carbon atoms; R2, R3 and R4 are independently selected from hydrogen, an alkyl group having 1 to 24 carbon atoms, or aromatic, aryl or alkyaryl groups having from 6 to 24 carbon atoms X is. an anion selected from but not limited to chloride, bromide, iodide, acetate, phosphate, nitrate, sulphate, lactate, citrate, and mixtures thereof.
Th glycolate, saccharinate e biocide.may constitute from 0.1% to
10% of the composition. Preferably the biocide of the present invention
shall constitute from 0.2% to 5% of the composition. Most preferably, the
biocide of the present invention shall constitute; from 0.5% to 2% of the
composition. ...
The non-ionic surfactant, in accordance with formula I, is an APG. Suitable APG's. have been described in US Patent No.s 3839318, 3772269, 3707535 and 3547828 afso in German and European patents and are commercially produced by reacting glucose or oligosaccharides with alcohols containing from 4 to 24 carbon atoms under acid catalysis.

With higher alcohols high reaction temperatures' and prolonged reaction times result in complex mixtures of mono-, di-, tri- and oligosaccharides and reference to APG's shall include complex mixtures as described.
A particular property of APG's is that although being formally classified as non-ionic surfactants they do exhibit very slight anionic behaviour. The APG's of the present Invention may constitute from 5% to 35% of the composition. Preferably, the APG's of the present invention shall constitute from 10% .to 20%o the composition-
If is well known in the art that amphoteric surfactants (also known as zwitteribnic surfactants) show synergistic interactions with anionic surfactants.
The present invention utilises, a non-ionic surfactant with very mild anionic properties and the use of an amphoteric surfactant has been shown to improve the cleaning performance of APG's (Henkel sales brochure on their GlUcopon range in April 1996). Since most classes of amphoteric surfactant are broadly compatible with the aforesaid biocides the nature of the amphoteric surfactant suitable for use in the present invention is not limited. Although the amphoteric surfactant may originate from a wide variety of sources those most suitable are derived from secondary and tertiary amines wherein the alkyl groups can be straight or branched alkyl chains between 1 and 22 carbon atoms long and may contain other

functional groups, for example amido groups. Preferably the nitrogen of the amphoteric surfactant of the present invention shall be in a cationic state wherein, the number of cations present in the molecule shall not be limited. At least one of the alky groups must contain an. ionisable head group which' can adopt a negative charge such as a carboxylase, sulphate, sulphonate, phosphate phosphonate, succinate, or sulfosuccinate.
Preferably, the amphoteric surfactants shall be chosen from betaines, sultaines hydroxysultaihes, iminopropionates and imihodipropionates
The amphoteric surfactant shall preferably constitute, from 2%. to. 20%. of the composition and advantageously from 5% to 15% of the composition.
The aforesaid constituents, (hereinafter referred to' as the key formula) form the basis'of the invention providing both washing ability and' antibacterial activity; however, in order to optimise the performance of the present invention additional constituents may be added. Preferably, a non-iohic foam booster shall be added to the key formula: for example, alkanoiamides and amine oxides; for example alkyl amine oxides and ethoxylated amine oxides such' as those available under the Aromox (RTM) range from Akzo Nobel Chemicals. The addition of these foam boosters has no detrimental effect on the biocidai efficacy of the present invention.
The foam booster may be added to the key formula in proportions not exceeding 10% of the composition.

Preferably, the foam booster, shall be added to the key formula in proportions from 2% to 6% of the composition.
These classes of nitrogen containing nonionic surfactants are well known to show synergistic and foam boosting effects when used in conjunction with anionic surfactants. It has been found that they exhibit similar beneficial effects when used in conjunction with the mildly anionic APG's.
Preferably, anionic surfactants shall be added to the key formula in order.to. influence the. feel rinsing and foaming properties and without markedly reducing the bactericidal efficiency of the invention.. The nature of the anionic surfactant is limited only by its compatibility with the key formula suitable anionic surfactants include sodium lauryi sulfate, sodium lauryi ether sulfate and sodium lauryi sarcosinate;'
The aforesaid, anionic surfactants may be tolerated by the key formula in proportions not exceeding 1 % of the total.
Preferably, minor amounts of specific nonionic surfactants may be added to the key formula in order to improve grease removal. Suitable non-ionic surfactants include alcohol alkoxylates and alky phenol alkoxylates. Preferably, the non-ionic surfactants shall be an alchohol ethoxylate having a cloud point below 20°C according to DIN 53917. The non-ionic surfactant may be included in the key formula In proportions not exceeding 10%.
Preferably, the non-ionic surfactant shall be included in the key

formula in proportions not exceeding 5% of the total.
Advantageously, the non-ionic surfactant shall be included in the key formula in proportions between 1% and 3% of the total.
The pH of the composition shall be between 5 and 9, and may be adjusted by the additions of small amounts of acid or base. .
Preferably, the pH of the composition shall be between 6 and 8. The acid employed to adjust the pH of the composition is not limited but preferably shall be chosen from...sulfamic citric hydrochloric, phosphoric, nitric, lactic, formic, acetic or gluconic but other mineral or organic acids may be used without detriment. ..
The base employed to adjust the pH of the composition is not limited but preferably shall be chosen from sodium or potassium hydroxide and mono-, di- or tri- ethanolamine but other bases may be used without detriment.
Furthermore, additional constituents may be added to the key formula including sequesterants, thickeners, perfurme, dye, and preservative. Careful selection of these ingredients is required since their inclusion is limited only by their compatability with the key formula.
The aforesaid additional constituents may be added to the key formula in proportions not exceeding 3% and.preferably, not exceeding 1%. It.should be noted that common co'mmercia! detergents for manual dishwashing typically contain between 15% and 40% total surfactant

content and the guideline inclusion rates described above are relevant to those typical detergent strengths. However, it is possible to manufacture very weak or very strong detergent solutions and any limits described above should be amended accordingly for such detergents.
Furthermore, the present invention is not based on petroleum' derived stocks but rather on renewable resources such as coconuts/palm kernafs and vegetable starch, and is therefore significantly more environmentally friendly both in terms ofbibdegradability and sustainability
It is to be understood,that all percentage values are measured. by. weight, and are relative to the total composition, unless otherWise stated. This invention will now be described further by reference to the following specific examples"-

Formulation A

CLASS OF COMPOUND COMPOUND ■ AMOUNT ADDED (%)
Non-ionic-surfactant C8-18 alkyl glycoside 14.35
Amphoteric surfactant Cocoamidopropyl betaine 10.62
Non-ionic foam booster Coconut diethanolamide 3.00
Non-ionic surfactant ■ C9-11 alcohol ethoxylate. (4E0) 1.50
Anionic surfactant Sodium lauryl sulfate 0.24 • .
Sequesterent' . Tetrasodium EDTA 0.30
Biocide PHMB hydrochloride' 0.90 '„.;„...
Cationic biocide Alkyl trimethyl' ammonium bromide, - 0.45
Acid Sulfamic acid (to pH 6.5) .0.33
Perfume Perfume 0.25
Dye Dye 0.005
Water Water 68.06
The antimicrobial efficacy of formulation A was determined using standard testing procedures (BS 6471). Formulation A passed the standard test at a dilution of 1 part product to 200 parts water by volume.

Formulation B

CLASS OF COMPOUND COMPOUND AMOUNT ADDED {%)
Non-ionic surfactant C9-16alky) glycoside 14.32
Amphoteric surfactant Cocoamidopropyl betaihe 6.62
Non-ionic foam booster Coconut diethanolamide 2.99
Non-ionic surfactant C 9-11alcohol ethoxylate (4E0) T.50
Non-ionic foam booster Myristyl amine oxide 3.99
Anionic surfactant Sodium lauryj-sulfate 0.24 '.
Sequesterent- - Tetrasodiiim EDTA- J3.30_ .:..;..-;; _
Biocide PHMB- hydrochloride 0:90
Cationic biocide Alkyl trimethyl ammonium bromide 0.45
Acid Sulfamic acid (to pH 6.5) 0,53
Perfume . Perfume, 0.25
Dye [ Dye 0.005
Water | Water 67.91
The antimicrobial efficacy of Formulation.B was deterrhihed using standard testing procedures (BS 6471).' Formulation B passed;t'he standard test at a dilution of 1 part product to 400 parts water by volume.
In use these formulations in aqueous solution at a 1% .dilution give rise to at least a 99% reduction in microbial activity when tested in accordance with BS 6471.
ft will be appreciated that the above formulations are given by way of example only and that many variations are possible within the scope of the invention.

1. A biocidal cleaning composition for washing dishes or hard surfaces
comprising from 0.1% to 10% of a biocide having cationic properties, from 5% to
35% of a surfactant of formula 1, from 2% to 20% of an amphoteric surfactant, and an
anionic surfactant in an amount not exceeding 1 wt%
Formula 1 R-0-(G)„
wherein R is an alkyl group
G is a saccharide residue and
n is a number from 0.4 to 10, characterised in that at a 1% aqueous dilution said composition produces a reduction of 99% in microbial activity.
2. A biocidal cleaning composition as claimed in claim 1, wherein the saccharide residue has 5 or 6 carbon atoms.
3. A biocidal cleaning composition as claimed in claim 1 or 2, wherein the alkyl group has 4 to 24 carbon atoms.
4. A biocidal cleaning composition as claimed in any preceding claim, wherein the biocide is a biguanide.
5. A biocidal cleaning composition as claimed in any of claims 1 to 3, wherein the biocide is a quaternary ammonium compound.
6. A biocidal cleaning composition as claimed in any of claims 1 to 4, wherein the biguanide is a salt of chlorhexidine.

7. A biocidal cleaning composition as claimed in any of claims 1 to 4, wherein
the biguanide is a salt of polyhexamethylene biguanide (PHMB) in accordance with
formula II.
Formula II

wherein: HX is a salt forming anion
n is a No. between 4 and 50, but preferably 12.
8. A biocidal cleaning composition as claimed in claim 5, wherein the quaternary
ammonium compound is of the following formula,

wherein: R1is alkyl (C6 to C24), aromatic, aryl or alkaryl (C6 to C24)
R2 is hydrogen, alkyl (C6 to C24), aromatic, aryl or alkaryl (C6 to C24) R3 is hydrogen, alkyl (C6 to C24), aromatic, aryl or alkaryl (C6 to C24) R4 is hydrogen, alkyl (C6 to C24), aromatic, aryl or alkaryl (C6 to C24)

X is chloride, bromide, iodide, acetate, phosphate, nitrate, sulphate, lactate, citrate, glycolate, saccharinate and mixtures thereof.
9. A biocidal cleaning composition as claimed in any of the preceding claims, wherein the biocide constitutes from 0.2% to 5% of the composition.
10. A biocidal cleaning composition as claimed in any of the preceding claims, wherein the biocide constitutes from 0.5% to 2% of the composition.
11. A biocidal cleaning composition as claimed in any preceding claim, wherein the surfactant is an APG.
12. A biocidal cleaning composition as claimed in claim 11, wherein the APG constitutes from 10% to 20% of the composition.
13. A biocidal cleaning composition as claimed in claim 1, wherein the amphoteric surfactant is derived from secondary or tertiary amines wherein the alkyl groups are straight or branched possessing between 1 and 22 carbon atoms.
14. A biocidal cleaning composition as claimed in any preceding claim, wherein the amphoteric surfactant shall constitute from 5% to 15% of the composition.
15. A biocidal cleaning composition as claimed in any preceding claim, wherein it comprises a foam booster.
16. A biocidal cleaning composition as claimed in claim 15, wherein the foam booster comprises 10% or less of the composition.
17. A biocidal cleaning composition as claimed in claims 15 and 16, wherein the foam booster shall constitute from 2% to 6% of the composition.
18. A biocidal cleaning composition as claimed in any preceding claim, wherein it comprises a non-ionic surfactant.

19. A biocidal cleaning composition as claimed in claim 18, wherein the non-ionic surfactant shall have a cloud point below 20°C.
20. A biocidal cleaning composition as claimed in claim 18 or 19, wherein the non-ionic surfactant comprises 10% or less of the composition.
21. A biocidal cleaning composition as claimed in claims 18, 19 or 20, wherein the non-ionic surfactant comprises from 1% to 3% of the composition.
22. A biocidal cleaning composition as claimed in any of the preceding claims, wherein the pH of the composition lies between 5 and 9.
23. A biocidal cleaning composition as claimed in any of the preceding, wherein the pH of the composition lies between 6 and 8.
24. A biocidal cleaning composition as claimed in any of the preceding claims, wherein it optionally comprises sequesterants, thickeners, perfume, dye and preservative.
25. A biocidal cleaning composition as claimed in claim 24, wherein each said optional constituent shall be added in a proportion not exceeding 3% of the composition.
26. A biocidal cleaning composition as claimed in claims 24 or 25, wherein each said optional constituent shall be added in proportions not exceeding 1% of the composition.
27. A biocidal cleaning composition comprising:
C8.16 alkyl glycoside 14.35 wt%
Cocoamidopropyl betaine 10.62 wt%
Coconut diethanolamide 3.00 wt%
C9-111 alcohol ethoxylate (4EO) 1.50 wt%
Sodium lauryl sulfate 0.24 wt%
Tetrasodium EDTA 0.30 wt%
PHMB hydrochloride 0.90 wt%

Alkyl trimethyl ammonium bromide 0.45 wt%
Sulfamic acid (to pH 6.5) 0.33 wt%
Perfume 0.25 wt%
Dye 0.005 wt%
Water 68.06 wt%
A biocidal cleaning composition comprising :
C8-16 alkyl glycoside 14.32 wt%
Cocoamidopropyl betaine 6.62 wt%
Coconut diethanolamide 2.99 wt%
C9-11 alcohol ethoxylate (4EO) 1.50 wt%
Myristyl amine oxide 3.99 wt%
Sodium lauryl sulfate 0.24 wt%
Tetrasodium EDTA 0.30 wt%
PHMB hydrochloride 0.90 wt%
Akyl trimethyl ammonium bromide 0.45 wt%
Sulfamic acid (to pH 6.5) 0.53 wt%
Perfume 0.25 wt%
Dye 0.005 wt%
Water 67.91 wt%



Dated this 10th day of September, 2003

Documents:

849-mumnp-2003-abstract(26-05-2008).pdf

849-mumnp-2003-abstract-(26-5-2008).doc

849-mumnp-2003-cancelled pages(26-05-2008).pdf

849-mumnp-2003-claims(granted)-(26-05-2008).pdf

849-mumnp-2003-claims(granted)-(26-5-2008).doc

849-mumnp-2003-correspondence(26-05-2008).pdf

849-mumnp-2003-correspondence(po)-(27-10-2008).pdf

849-mumnp-2003-form 2(granted)-(26-5-2008).doc

849-mumnp-2003-form 13(27-05-2008).pdf

849-mumnp-2003-form 18(31-01-2006).pdf

849-mumnp-2003-form 1a(10-09-2003).pdf

849-mumnp-2003-form 1a(26-05-2008).pdf

849-mumnp-2003-form 2(granted)-(26-05-2008).pdf

849-mumnp-2003-form 3(10-09-2003).pdf

849-mumnp-2003-form 3(17-05-2004).pdf

849-mumnp-2003-form 3(26-05-2008).pdf

849-mumnp-2003-form 5(10-09-2003).pdf

849-mumnp-2003-form-pct-isa-210(26-05-2008).pdf

849-mumnp-2003-petition under rule 137(27-05-2008).pdf

849-mumnp-2003-petition under rule 138(27-05-2008).pdf

849-mumnp-2003-power of authority(06-10-2003).pdf

849-mumnp-2003-power of authority(26-05-2008).pdf


Patent Number 224954
Indian Patent Application Number 849/MUMNP/2003
PG Journal Number 02/2009
Publication Date 09-Jan-2009
Grant Date 27-Oct-2008
Date of Filing 10-Sep-2003
Name of Patentee SELDEN RESEARCH LTD.
Applicant Address ASHBOURNE ROAD, BUXTON, DERBYSHIRE SK17 9RZ, USA.
Inventors:
# Inventor's Name Inventor's Address
1 PETER PHILIP WOODHEAD 18 MOOR END ROAD, MELLOR, STOCKPORT, CHESHIRE SK6 5PS, UK.
PCT International Classification Number C11D1/94
PCT International Application Number PCT/GB02/00710
PCT International Filing date 2002-02-19
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 0105342.0 2001-03-03 U.K.