Title of Invention	INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2
Abstract	The invention discloses a compound of the formula (I): wherein R, R1, R2, R3, R4, X1, X2, n1 and n2 are as defined in the specification an effective inhibitor of cytosolic phospholipase A2 and process for its preparation.

Full Text

INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 The present invention relates to chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2a) and to novel N-benzhydryl indole intermediates therefor. The invention also relates to methods for treating or alleviating asthma and the symptoms of asthma and/or the symptoms of arthritic and rheumatic disorders in mammals, including humans utilizing these chemical inhibitors. Background of the Invention Leukotrienes and prostagtandins are important mediators of inflammation, each of which contributes to the development of an inflammatory response in a different way. Leukotrienes recruit inflammatory cells such as neutrophils to an inflamed site, promote the extravasation of these cells and stimulate release of superoxide and proteases which damage the tissue. Leukotrienes also play a pathophysiological role in the hypersensitivity experienced by asthmatics [See, e.g. B. Samuelson et at., Science. 237:1171-76 (1987)]. Prostaglandins enhance inflammation by increasing blood flow and therefore infiltration of leukocytes to inflamed sites. Prostaglandins also potentiate the pain response induced by stimuli. Prostaglandins and leukotrienes are unstable and are not stored in cells, but are instead synthesized [W. L Smith, Biochem. J.. 259315-324 (1989)1 from arachidonic add in response to stimuli. Prostaglandins are produced from arachidonic acid by the action of COX-1 and COX- 2 enzymes. Arachidonic acid is also the substrate for the distinct enzyme pathway leading to the production of leukotrienes. Arachidonic acid which is fed into these two distinct inflammatory pathways is released from the sn-2 position of membrane phospholipids by phospholipase A2 enzymes (hereinafter PLA2). The reaction catalyzed by PLA2 is believed to represent the rate-limiting step in the process of lipid mediated biosynthesis and the production of ammatory prostaglandins and leukotrienes. When the phospholipid substrate of PLA2 is of the phosphotidyl choline class with an ether linkage in the sn~1 position, the lysophospholipid produced is the immediate precursor of platelet activating factor (hereafter called PAF), another potent mediator of inflammation [S.I. Wasserman, Hospital Practice, 15:49-58 (1988)]. Most anti-inflammatory therapies have focused on preventing production of either prostglandins or leukotrienes from these distinct pathways, but not on alt of them. For example, ibuprofen, aspirin, and indomethacin are all NSAIDs which inhibit the production of prostaglandins by COX-1/COX-2 inhibition, but have no effect on the inflammatory production of leukotrienes from arachidonic acid in the other pathway. Conversely, zileuton inhibits only the pathway of conversion of arachidonicdonic acid to leukotrienes, without affecting the production of prostaglandins. None of these widely-used anti-inflammatory agents affects the production of PAF. Consequently the direct inhibition of the activity of PLA2 has been suggested as a useful mechanism for a therapeutic agent, i.e., to interfere with the inflammatory response. [See. e.g., J. Chang et al, Biochem. Pharmacol.. 2§:2429-2436 (1987)]. A family of PLA2 enzymes characterized sequenced and ultimately secreted from the cell have been sequenced and structurally defined. These secreted PLA2S have an approximateiy 14 kD molucular weight and contain seven disulfide bonds which are necessary for activity.these PLA2S are found in large quantities in mammalian pancreas, bee venom, and various snake venom. [See, e.g., references 13-15 in Chang et al, cited above; and E. A. Dennis, Druo Devel. Res.. 10:205-220 (1987).] However, the pancreatic enzyme is believed to serve a digestive function and, as such, should not be important in the production of the inflammatory mediators whose production must be tightly regulated. The primary structure of the first human non-pancreatic PLA2 has been determined. This non-pancreatic PLA2 is found in platelets, synovial fluid, and spleen and is also a secreted enzyme. This enzyme is a member of the aforementioned family. [See, J. J. Seilhamer et al, J. Biol. Chem.. 264:5335-5338 (1989); R. M. Kramer et al, J. Biol. Chem.. 264:5768-5775 (1989); and A. Kando et al, Biochem. Biophys. Res. Comm.. 163:42-48 (1989)]. However, it is doubtful that this enzyme is important in the synthesis of prostaglandins, leukotrienes and PAF, since the non- pancreatic PLA2 is an extracellular protein which would be difficult to regulate, and the next enzymes in the biosynthetic pathways for these compounds are intracellular proteins. Moreover, there is evidence that PLA2 is regulated by protein kinase C and G proteins [R. Burch and J. Axelrod, Proc. Natl. Acad. Sci. U.S.A.. 84:6374-6378 (1989)] which are cytosolic proteins which must act on intracellular proteins. It would be impossible for the non-pancreatic PLA2 to function in the cytosol, since the high reduction potential would reduce the disulfide bonds and inactivate the enzyme. A murine PLA2 has been identified in the murine macrophage cell line, designated RAW 264.7. A specific activity of 2 mois/min/mg, resistant to reducing conditions, was reported to be associated with the approximately 60 kD molecule. However, this protein was not purified to homogeneity. [See, C. C. Leslie et al, Biochem. Biophvs. Acta.. 963:476-492 (1988)]. The references cited above are incorporated by reference herein for information pertaining to the function of the phospholipase enzymes, particularly PLA2 A cytosolic phospholipase A2 alpha (hereinafter "cPLA2a) has also been identified and cloned. See, U.S. Patent Nos. 5.322.776 and 5.354,677, which are incorporated herein by reference as if fully set forth. The enzyme of these patents is an intraceliular PLA2 enzyme, purified from its natural source or otherwise produced in purified form, which functions intracellulariy to produce arachidonic acid in response to inflammatory stimuli. Now that several phospholipase enzymes have been identified, it would be desirable to identify chemical inhibitors of the action of specific phospholipase enzymes, which inhibitors could be used to treat inflammatory conditions, particularly where inhibition of production of prostaglandins, Ieukotrienes and PAF are all desired results. There remains a need in the art for an identification of such anti- inflammatory agents for therapeutic use in a variety of disease states and intermediates for their preparation. DETAILED DESCRIPTION OF THE INVENTION This invention comprises compounds of the formula (I): wherein: R is selected from the formulae -(CH2)n-A -(CH2)n-S-A, or -(CH2)-O-A, wherein A is selected from the moieties: wherein D is C1-C6 lower alkyl, C1-C6 lower alkoxy, C3-C6 cydoalkyl, -CF3 or -(CH2)1-3-CF B and C are independently selected from phenyl, pyridinyl, pyrimidinyl, furanyt, thiophenyl or pyrroiyi groups, each optionally substituted by from 1 to 3, preferably 1 to 2, substituents selected independently from H, halogen, -CN, -CHO, - CF3, -OCF,. -OH, -C1-C6 alkyl, C1-C6 alkoxy. -NH2, -N(C1-C6 alkyl)2 -NH(C1-C6 alkyl), -N-C(OHC1-C6 alkyL), -NO2 or by a 5- or 6-membered heterocyclic or heteroaromatic ring containing 1 or 2 heteroatoms selected from O, N or S; or n is an integer from 0 to 3; n1 is an integer from 1 to 3; n2 is an integer from 0 to 4; n3 is an integer from 0 to 3; a, is an integer from 0 to 2; X1 is selected from a chemical bond, -S-, -O-, -S(O)-, -S(O)2-, -NH-, -NHC(O)- .-C=C-, R-1 is a moiety selected from C1-C6 alkyl, C1-C6 fluorinated alkyl, C3-C6 cydoalkyl, tetrahydropyranyl, camphoryl, adamantyl, CN, -N(C1-C6 alkyl)2, phenyl, pyridinyl, pyrimidinyl, fury), thienyl, naphthyl, morphollnyl, triazotyl, pyrazolyl, piperidinyl, pyrrolidinyl, imidazolyl, piperazinyl, thiazolidinyl, thiomorphoiinyl, tetrazole, indole, benzoxazole, benzofuran, imidazolidine-2-thione, 7,7,dimethyl- bicyclo[2.2.1Jheptarn-2-one, benzo[1,2,5]oxadiazole, 2-oxa-5-aza- bicydo[2.2.1]heptane, piperazin-2-one or pyrrolyl groups, each optionally substituted by from 1 to 3, preferably 1 to 2, substituents independently selected from H, halogen, -CN, -CHO, -CF,, OCF,,-OH, -C1-C6fl alkyl. C1-C6 alkoxy, -NH2 ,-N(C1-C6 alkyl)2l -NH(C1-C6 alkyl). -N-C(O)-(C1-C6 alkyl), -NO2, -SO2(C1-C3 alkyl). -SO2NH2 - SO2NH(C1-C3 alkyl), -S02N(C1-C3 alkyfc. -COOH, -CH2-COOH, -CH2N(C1-C6, alkyl), -CH2N(C1-C6 alkyl)2, -CH2NH2, pyridine, 2-methyl-thiazole, morpholino, 1-chloro-2- methyt-propyl, -C1-C6 thioalkyl. phenyl (further optionally substituted with halogens), benzyloxy, (C1-C3 alkyl)C(O)CH3, (C1-C3 alkyl)OCHs, C(O)NH2, or R2 is a ring moiety selected from phenyl, pyridinyl, pyrimidinyl, furyl, thienyl or pyrrolyl groups, the ring moiety being substituted by a group of the formula -(CH2)n4- CO2H or a pharmaceutically acceptable add mimic or mimetic; and also optionally substituted by 1 or 2 additional substituents independently selected from H, halogen, -CN, -CHO, -CF3, -OCFS, -OH, -Ct-Ce alkyl. C1-C6e alkoxy, C-C, thioalkyl, -NH2, - N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; R3 is selected from H, halogen. -CN, -CHO, -CF3, -OCF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2. -N(C1-C6 alkyI)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; R4 Is selected from H, halogen, -CN, -CHO, -CF3, -OCF3, -OH, -C1-C6 alkyl, C3-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(OMC1-C6 alkyl), -NO2 -N-C(O)-N(C1-C3 alkyl)2, -N-C(O)NH(C1-C6 alkyl). -N-CfOKKC1-C6 alkyl), -SO2-C1-C6 alkyl. -S-C1-C6 cycloalkyl, -S-CH2-C1-C6 cycloalkyl, -SO2C1-C6 cydoalkyl.. -SOz-CHz-C1-C6 cycloalkyl, C1-C6 cycloalkyl. -CHrC1-C6 cycloalkyl, -O- C3-C6 cycloalkyl,, -O-CHrC1-C6 cycloalkyl, phenyl, benzyl, benzytoxy, morpholino or other heterocyctes such as pyrrolidino, piperidine, piperizine furan, thiophene, imidazole, tetrazote, pyrazine, pyrazdone, pyrazole, imidazote, oxazote or isoxazole, the rings of each of these R4 groups each being optionally substituted by from 1 to 3 substituents selected from the group of H, halogen, -CN, -CHO, -CF3, -OH, -C1-C6« alkyl. C1-C6 alkoxy. -NH2, -N(C1-C6 alkyl)2 -NH(C1-C6 alkyl), -N-C(OMC1-C6 alkyl). - NO2. -SO2(C1-C6 alky)). -SO2NH(C1-C3 alkyl), -SO2N(C1-C3 alkylh, or OCF,; or a pharmaceutically acceptable salt form thereof. It will be understood that the C1-c6 fluorinated alkyl groups in the definition of R1 may be any alkyl group of 1 to 6 carbon atoms with any amount of fluorine substitution including, but not limited to, -CFS, alkyl chains of 1 to 6 carbon atoms terminated by a trifluoromethyl group, -CF2CF3, etc. Ester forms of the present compounds include the pharmaceutically acceptable ester forms known in the art including those which can be metabolized into the free acid form, such as a free carboxylic acid form, in the animal body, such as the corresponding alkyl esters, cycloalkyl esters, aryl esters and heterocyclic analogues thereof can be used according to the invention, where alkyl esters, cycloalkyl esters and aryl esters are preferred and the alcoholic residue can cany further substituents. C1-C6 alkyl esters, preferably C1-C6 alkyl esters, such as the methyl ester, ethyl ester, propyl ester, isopropyl ester, butyl ester, isobutyl ester, t- butyl ester, pentyl ester, isopentyl ester, neopentyl ester, hexyl ester, cydopropyi ester, cyclopropylmethyl ester, cyclobutyl ester, cyclopentyl ester, cyclohexyl ester, or aryl esters such as the phenyl ester, benzyl ester or tolyl ester are particularly preferred. In the definition of X1, the alkenyl bridging group -C=C- is understood to indicate either the cis or trans orientation of the indicated compound(s). Pharmaceutically acceptable acid mimics or mimettcs useful in the compounds of this invention include those wherein R2 is selected from the group of: ¦ wherein Ra is selected from -CF3, -CH3, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -CF3, halogen, -OH, or -COOH; Rb is selected from - CF3, -CH3, -NH2, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, C1-C6« alkoxy, C1-C6 thioalkyl. -CF9> halogen, -OH, or -COOH; and Rc is selected from -CF3 or C1-C6 alkyl. In the compounds of this invention subgroups therof and intermediates therefore examples of variables are as follows:- Examples of R is -(CH2)n-A, eg where n is 0 and/or wherein A is the moiety: wherein B and C are as defined herein. Examples of B and C are each independently unsubstituted phenyl, pyridinyl, pyrimidinyl, furyl, thienyl or pyrrolyl groups, eg wherein A is the moiety: Examples of R3 are selected from H, halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6thioalkyl, -NH2,-N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)- (C1-C6alkyl)and-NO2. Examples of R4 are selected from H, halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6, thioalkyl, -NH2,-N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)- (C1-C6 alkyl), -NO2, morpholino or other heterocydes such as pyrrolidino, piperidine, piperazine, furan, thiophene, imidazole, tetrazote, pyrazine, pyrazolone, pyrazote, imidazole, oxazole and isoxazole. In some embodiments R3 and R4 are bonded to the 5 and 6 positions of the indole ring. An example of n3 is 1. Examples of X2 are O.-SQ2, -NH- and -CH2. Examples of R2 are moieties selected from: or a phamnaceuticalty acceptable acid mimic or mimetic, wherein a, is 0-2 and R8 and R9 are independently selected from H, halogen, -CN, -CHO, -CF3, - OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl. -NH2, -N(C1-C6 alkyl), -NH(C1-C6 alkyl). -N-C(OHC1-C6 alkyl). or -NO2 An example of ru is 0. In some embodiments the -(CH2)n2-CO2H moiety, or the pharmaceutically acceptable acid mimic or mimetic, is in the 4-position of the phenyl ring. Examples of n1 are the integers 1 or 2. Examples of n2 are 0, 1 or 2; for- example, n1 and n2 may both be 1. X1 may be for example selected from a chemical bond, -S-, -O-, -NH- or - N(C1-C6 alkyl)-. Examples of R1 are C1-C6 alkyl, C1-C6 cycloalkyl, phenyl, pyridinyl, naphthyl, tetrazole, each optionally substituted by from 1 to 3 substituents independently selected from H, halogen, -CN, -CHO, -CF3. OCF3.-OH, -C1-C6 alkyl, C1-C6 alkoxy, - NH2, -N(C1-C6 alkyl)2. -NH(C1-C6 alkyl), -N-C(0)-(C1-C6 alkyl), -NO* -SO2(C1-C3 alkyl), -SO2NH2. -SO2NH(C1-C3 alkyl), -SO2NC1-C6 alkylk. -COOH, -CHrCOOH, - CH2-N(C1-C6 alkyl). -CHrN(C1-C6 alkyl),, -CH2-NH2 -C1-C6thioalkyl, phenyl (further optionally substituted with halogens), benzytoxy, -(C1-C3 alkyl)C(O)CH3, -(C1-C6 alkyl)OCH3 and -C(O)NH2. In some embodiments R1 has the fomula: wherein R5, R6 and R6 are independently selected from H, halogen, -CN, - CHO, -CF3, OCF3,-OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2. -NH(C1-C6 alkyl). -N--C(O)-C1-C6 alkyl) and -NO2. A first subgroup of compounds of this invention, or a pharmaceutically acceptable salt thereof, include those of the group above wherein A is the moiety: and B, C, n, n1, n2, n3, n4, R, X,, X2, R1, R2, R3, and R4 are as defined above. A second subgroup of compounds of this invention comprises those of the first subgroup, above, wherein B and C are unsubstrtuted phenyl, pyridinyl, pyrimidinyl, furyl, thienyt or pyrrolyl groups and R, n, n1, n2, n3, n4, R1, X1, X2, R2, R3. and R4 are as defined above. A third subgroup of compounds and pharmaceutically acceptable salt forms of this invention comprise those of the second subgroup, above, wherein A is the moiety: and n, n1, n2, n3, n4, R, X1, X2, R1, R2, R3, and R4 are as defined above. A fourth subgroup of compounds of this invention comprises those of the formulae (II) or (III): wherein n1, n2, n3, n4, X1, X2, R1, R2, R3, and R4 are as defined above, or a pharmaceutically acceptable salt thereof. A fifth subgroup of compounds of this invention includes those of formulae (II) or (III) wherein n3 = 1, and n1, n2, n4, X1, X2, R1, R2, R3, and R4 are as defined above, or a pharmaceutically acceptable salt thereof. A sixth subgroup of compounds of this invention includes those of the fifth subgroup, above, wherein R2 is phenyl substituted by a group of the formula - (CK2)n4-CO2H, and optionally substituted by 1 or 2 additional substituents independently selected from H, halogen, -CN, -CHO, -CF3> -OH, -C1-C6 alkyt, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2 , -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(OHC1-C6 alkyf), or -NO; and n1, n2, n4, R1, X1, X2, R2, R3, and R4 are as defined above, or a pharmaceutically acceptable salt thereof. A seventh subgroup of compounds of this invention comprises those of the formula© (IV) or (V): wherein: n1 is an integer from 1 to 3; n2 is an integer from 1 to 3; R5, R6 and R6- are independently selected from H, halogen, -CN, -CHO, -CF3, -OCF=, -OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N- C(O)-(C1-C6 alkyl).or-NC2; X1 is selected from a chemical bond, -S-, -O-, -NH- or -N(C1-C6 alkyl)-; X2 is selected from -O-, -SCv or -CH2-; R2 is a moiety selected from the group of: R8, and R9. are independently selected from H, halogen, -CN, -CHO, -CF3, - OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1- C, alkyl), or -NO2 n4 is an integer from 0 to 2; R3 is selected from H, halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2 , -N(C1-C6 alkyl),, -NH(C1-C6 alkyl), -N-C(OHC1-C6 alkyl), or -NO2; and R4 is selected from H, halogen, -CN. -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl. -NH2 , -N(C1-C6 alkyl)2. -NH(C1-C6 alkyl). -N-C(O)-(C1-C6 alkyO, -NO2 morpholino or other heterocycles such as pyrrolidino, piperidine, piperazine, furan, thiophene, imidazole, tetrazole, pyrazine, pyrazolone, pyrazole, imidazole, oxazole or isoxazole; or a pharmaceutically acceptable salt form thereof. An eighth subgroup of compounds of this invention include those of the formulae (VI) or (VII): wherein: X1 is selected from a chemical bond, -S-. -O-. -NH- or -N(C1-C3 alkyl)-; X2 is selected from -O-. -SO2. or -CH2; R3 is selected from H, halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6, thioalkyl, -NH2.-N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyO, or-NO2;and R4, is selected from H, halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2,-N(C1-C6 alkyl)2. -NH(C1-C6 alkyl), -N-C(OHC1-C6 alkyl), -NO2l morpholino or other beterocyctes such as pyrrolidino, piperidine, piperizine, furan, thiophene, knidazole, tetrazole, pyrazine, pyrazolone, pyrazote, imidazote, oxazole or isoxazole; r»i is an integer from 1 to 2; n2 is an integer from 1 to 2; R5, R5 and R6- are independently selected from H, halogen, -CN, -CHO, -CF3, -OCF,, -OH. -C1-C6 alkyl. C1-C6 alkoxy, -NH2,-N(C1-C6 alkyl)2 -NH(C1-C6 alkyl). -N- C(O)-(C1-C6 alkyl),or-N02; R8 and R9 are independently selected from H, halogen, -CN, -CHO, -CF3, - OH. -C1-C6 alkyl, C1-C6, alkoxy. -NH2. -N(C1-C6 alkyl)2 -NH(C1-C6 alkyl), -N-C(O)-(C,- C, alkyl). or -NO2; or a pharmaceutically acceptable salt form thereof. A ninth subgroup of compounds of this invention include those of formulae (VI) or (VII) wherein: n1, is 1; n2 is 1; and X1, X2, R3, R4, R5. R6. R6. R8 and R9 are as defined in the eighth subgroup, above, or a pharmaceutically acceptable salt form thereof. A tenth subgroup of this invention comprises the compounds of the ninth subgroup, above, wherein X1 is a chemical bond and n1 n2 X2, R3, R4, R5, R6. R6-, R6 and R9 are as defined in the ninth subgroup, above, or a pharmaceutically acceptable salt form thereof. An eleventh subgroup of compounds of this invention comprises those of the formulae (VIII) or (IX) wherein: n1, is an integer from 1 to 3; n2is 0; X1 is a chemical bond; n3, n4, X2, R1, R2 R3, and R4 are as defined above, or a pharmaceutically acceptable salt thereof. A twelfth subgroup of compounds of this invention comprises those of the formulae (X)or(XI) wherein: n1 is an integer from 1 to 3; n2 is O; R5, R6 and R6 are independently selected from H, halogen, -CN, -CHO, -CF3, -OCF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl). -N- C(OHC1-C6,alkyl,or-NO2; X1 is a chemical bond X2 is selected from -O-, -SOr, or -CH2-; R2 is a moiety selected from the group of: R8 and R9 are independently selected from H, halogen, -CN, -CHO, -CF3, - OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl). -N-C(O)-(C1- C6 alkyl). or-NO2 n4 is an integer from 0 to 2; R3 is selected from H, halogen, -CN, -CHO. -CF3, -OH, -C-Cs alkyl, C3-C6 alkoxy. C1-C6 thioalkyl. -NH2, -N(C1-C6 alkyl)* -NH(C3-C6 alkyl). -N-C(OMC1-C6 alkyl), or-NO* and R4, is selected from H, halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl. C1-C6 alkoxy, C1-C6 thioalkyl. -NH2, -N(C1-C6 alkyl)* -NH(C1-C6 alkyl), -N-C(OHC1-C6 alkyl), -NO2, morpholino or other heterocycles such as pyrrolidino, piperidine, piperizine, furan, thiophene, imidazole, tetrazole, pyrazine, pyrazolone, pyrazoie, imidazole, oxazole or isoxazoie; or a pharmaceutjcally acceptable salt form thereof. A thirteenth subgroup of compounds of this invention include those of the formulae (XII) or (XIII): wherein: X1 is a chemical bond; X2 is selected from -O-, -SCV. or -CH2; R3 is selected from H, halogen, -CN, -CHO, -CF3. -OH, -C1-C6 alkyl, C1-C6, alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl). -N-C(OMC1-C6 alkyl). or -NO* and R4 is selected from H, halogen. -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(OKC1-C6 alkyl), -NO2, morpholino or other heterocydes such as pyrrolidino, piperidine, piperizine, furan, thiophene, imkJazole, tetrazole, pyrazine, pyrazolone, pyrazole, imidazole, oxazole or isoxazole; ni is an integer from 1 to 2; n2 is O; Rs. Re and Rr are independently selected from H, halogen, -CN, -CHO, -CF3, -OCF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N- C(O)-(C1-C6, alkyl). or -NC* R8 and R9 are independently selected from H, halogen, -CN, -CHO, -CF3, - OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6« alkyl). -N-C(OHd- C6 alkyl), or-NO2; or a pharmaceurtically acceptable salt form thereof. The compounds of the invention can be used in the treatment, inhibition, alleviation or relief of asthma and asthmatic conditions. The methods of treatment, inhibition, alleviation or relief of asthma and asthmatic conditions of this invention include those for Extrinsic Asthma (also known as Allergic Asthma or Atopic Asthma), Intrinsic Asthma (also known as Nonallerglc Asthma or Nonatopic Asthma) or combinations of both, which has been referred to as Mixed Asthma. The methods for those experiencing or subject to Extrinsic or Allergic Asthma include incidents caused by or associated with many allergens, such as pollens, spores, grasses or weeds, pet danders, dust, mites, etc. As allergens and other irritants present themselves at varying points over the year, these types of incidents are also referred to as Seasonal Asthma. Also included in the group of Extrinsic Asthmas is bronchial asthmas and allergic bronchopulminary aspergillosis. Intrinsic Asthmas that may be treated or alleviated by the present methods include those caused by infectious agents, such as cold and flu viruses in adults and respiratory syncyttal virus (RSV), rhinovirus and influenza viruses common in children. Also included are the asthma conditions which may be brought about in some asthmatics by exercise and/or cold air. The methods are useful for Intrinsic i Asthmas associated with industrial and occupational exposures, such as smoke, ozone, noxious gases, sulfur dioxide, nitrous oxide, fumes, including isocyanates, from paint plastics, polyurethanes, varnishes, etc., wood, plant or other organic dusts, etc. The methods are also useful for asthmatic incidents associated with food additives, preservatives or pharmacological agents. Common materials of these types are food coloring such as Tartrazine, preservatives like bisulfites and metabisulfites, and pharmacological agents such as aspirin and norvsteroidal anti- inflammatory agents (NSAIDs)A Also included are methods for treating, inhibiting or alleviating the types of asthma referred to as Silent Asthma or Cough Variant Asthma The methods herein are also useful for treatment and alleviation of Intrinsic Asthma associated with gastroesophageal reflux (GERD), which can stimulate bronchoconstriction. GERD, along with retained bodily secretions, suppressed cough, and exposure to allergens and irritants in the bedroom can contribute to asthmatic conditions and have been collectively referred to as Nighttime Asthma or NocLrnal Asthma. In methods of treatment, inhibition or alleviation of asthma associated with GERD, a pharmaceuticaNy effective amount of the compounds of this invention may be used as described herein in combination with a pharmaceutically effective amount of an agent for treating GERD. These agents include, but are not limited to, proton pump inhibiting agents like PROTONIX* brand of delayed-release pantoprazole sodium tablets, PRILOSEC* brand omeprazole delayed release capsules, ACIPHEX* brand rebeprazole sodium delayed release tablets or PREVACID* brand delayed release lansoprazole capsules. Pharmaceutically effective amounts of these agents are understood to include those described in the conventional medical literature, including the pharmaceutically effective doses and regimens for these agents described in the 2001 Physicians' Desk Reference (55 Edition), published by Medical Economics Company, Montvale, New Jersey 07645- 1742. The compounds of this invention are useful in the alleviation, inhibition, relief and treatment of arthritic disorders in a mammal. The methods of this invention include alleviation, inhibition, relief and treatment in a mammal of arthritic disorders including, but not limited to, rheumatoid arthritis, spondyloarthropathies, gouty arthritis, infectious arthritis, osteoarthritis (which includes erosive osteoarthritis and is also known as osteoarthrosis or degenerative joint disease or DJD), systemic lupus erythematosus and juvenile arthritis. Each of these methods comprises administering to a mammal in need of such action a pharmaceutically effective amount of a substituted indole of this invention, as described herein, or a pharmaceutically acceptable salt or ester form thereof. The methods of this invention include those for arthritic conditions associated with spondylitis, including ankylosing spondylitis, reactive arthritis (Rotter's syndrome).psoriatic arthritic arthritis associated with inflammatory bowel disease and AIDS--related seronegative spondyloarthropathy. This invention also provides methods for treating, alleviating or inhibiting rheumatic disease and disorders. These methods are useful for treatment of systemic lupus erythematosus, systemic sclerosis and forms of scleroderma, polynnyositis, dermatomyositis, necrotizing vasculitis and other vasculopathies, hypersensitivity vasculitis (including Henoch-Schonlein purpura), Wegener's granulomatosis, Giant cell arteritis, mucocutaneous lymph node syndrome (Kawasaki disease), Behcet's syndrome, Cryoglobulinemia, juvenile dermatomyositis, Sjogren's syndrome, overlap syndromes (includes mixed connective tissue disease), polymyalgia rheumaticqa, erythema nodosum, relapsing polychondritis, tendonitis (tenosynovitis), Bicipital tendenitis, bursitis, olecranon bursitis, adhesive capsulitis of the shoulder (frozen shoulder) trigger finger, and Whipple's disease. The compounds of this invention are also useful in the treatment, alleviation or inhibition of metabolic and endocrine diseases with rheumatic states, including gout, pseudogout, chondrocalcinosis, amyloidosis, scurvy, speicific enzyme deficiency states (including Fabrys disease, alkaptonuria, ochonosisi, Lesch-Nynan syndrome, and Gaucher's disease), hyperlipoproteinemias (types II, lla, IV), ENers- Danlos syndrome, Marian's syndrome, pseudoxanthoma elasttcum, Wilson's disease. Also treatable with the present methods are the rheumatic states associated with endocrine diseases, such as diabetes mellitus, acromegaly, hyperparathyroidism, myositis ossiftcarts progressiva, hypermobility syndromes, arthrogryposis multiplex congenita, and thyroid diseases such as thyroiditis, hypothyroidism and hyperthyroidism. These methods may also be used for rheumatic conditions associated with neoplasms such as primary neoplasms (synovioma), metastatic neoplasms, multiple myeloma, leukemia and lymphomas, pigmented villonoduriar synovitis, osteochondromatosis and others. Also included among the methods of this invention are relief from the rheumatic conditions associated with neuropathic disorders including, Charcot's joints, hand-arm vibration syndrome (also known as vibration-induced white finger or Raynaud's phenomenon), repetitive stress syndromes, reflex sympathetic dystrophy and compression neuropathies, such as peripheral entrapment (including carpal tunnel syndrome, pronator syndrome, thoracic outlet syndromes and tarsal tunnel syndrome), radiculopathy and spinal stenosis. The compounds and methods of this invention are useful in treating, alleviating and inhibiting these conditions and the pain and inflammation with which they are associated. Methods for treating, relieving, inhibiting or alleviating each of these conditions in a mammal, comprises administering to a mammal in need of such activity a pharmaceutically effective amount of a compound of this invention, alone or in combination with another agent, such as an anti-rheumatic, anti-inflammatory or analgesic pharmaceutical agent. A further method of treatment of asthma of this invention comprises administering to a mammal in need of such treatment a pharmaceutically effective amount of a compound of this invention, as described above, and a pharmaceutically effective amount of one or more additional anti-asthma agents. Anti-asthma agents useful with these combinations include long-term-control medications, such as corticosteroids (glucocorticoids), cromolyn sodium (disodium cromoglycate - DSCG), nedocromil, methylxanthines (such as theophyUine) and leukotriene modifiers. Useful leukotriene modifiers include leukotriene receptor antagonists, such as zafiriukast (ACCOLATE®) and monetiukast (SINGULAIR®), and 5-lipoxygenase inhibitors, such as zileuton (ZYFLO®). Useful corticosteroids include inhaled products, such as Beclomethasone dipropionate, Budesonide, Flunisolide, FkJticasone, and Triamcinolone, as well as the pharmaceutically acceptable salt forms thereof. Also useful are systemic corticosteroids such as prednisone, prednisotone and methytprednisolone. Also useful are quick-relief anti-asthma medications, such as long-acting betar-agonists, short-acting betaragonists, anticholinergics and systemic corticosteroids. B-Adrenergic agents which may be used include epinephrine, isoproterenol, metaproterenol, terbutaline, isoetharine, albuterol, brtolterol and perbuterol. Useful anticholinergic agents include atropine (and its derivative ipatropium bromide) and glycopyrrolate. The compounds of this invention may also be used to treat asthma in conjunction with allergy immunotherapies, which also referred to in the art as hyposensitization therapies. These compounds may be administered according to the dosages and regimens known in the art. Additional anti-asthma agents which may be used in the combinations of this invention include pranlukast, anakinra, seratrodast, olopatadine hydrochloride, cromoglicate lisetil, ramatroban, interieukin-4 receptor (Immunex), urodilatin, coiforsin daropate, salbutamol, LCB-2183, andoiast, ciclesonide, budesonide, formoterol, omalizumab, tranilast, saredutant, CDP-835 (antHL-5 Mab), fexofenadine HCI, N-(1- (Chlorophenyl)-1-methylethyl)-3-(midazol-1-yl) propylamiriedihydrochloride (BTS-71- 321), cilomilast, bimosiamose, Corticotropin-releasing factor, clenoliximab, tiotropium bromide, 2H-1,2-Benzoselenazine, 3,4-dihydn-4l4-dimethyl (BXT-51072), atreleuton, (R)-salbutamol, 8-Methoxyquinoline-5-(N-(2,5-dichloropyndin-3-yl)) carboxamide (D- 4418), triamcinolone acetonide, KW-4490 (KF-19514), LAX-300 (LX-109), IDEC-152 (ST-152; anti-CD23 antibody), cytokine Traps, anandamide, SRL-172, salmeterol + Ruticasone, KCA-757,2-PyridinecarboxyIic acid, 6-(2-(3,4-diethoxyphenyl)4- thiazolyl)- (OPC-6535), PM-56D9, salbutamol. CT-2820 (PDEIV inhibitors), beclometasone, nepadutant, ketotifen fumarate, DHEAS (PB-005), Pharmaprojects No.5163, No. 5278 and No. 5297, salbutamol sulfate, EPI-2010 (EpiGenRx), mepolirumab, Benzamide, N-(5-(3-(4-chlorophenyl)sulfonyl)propy1)-2-(1H-tetrazol- S-ylmethoxy)phenyl)-((1.1diirnethylethyl)-2-thiazolyOmethoxy)-, monosodium salt (YM-158), 2-(4-ethoxycarbonylamlnoben2yl)-6-(3>4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazirv-3-one Pharmaprojects (No.5450), Sch-205528, L-826141 (Pharmaprojects No. 5477), Budesonide, duramydn, 4,4-Bis(4-(quinolJn-2- ylmethoxy)phenyl)pentanoic add sodium salt (VML-530), IL-9 inhibitor, beclometasone dipropionate, formoterol, cydo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD-7349), salbutamol, Ethanaminium,2-(((2-acetyl-4-((1-oxohexadecyl)amino) phenoxy) hydroxypho8phiny!)oxy)-N, N, N-trimethyt-, inner salt (CPR-2015), PD- 168787 (CI-1018), cathepsin S inhibitors. SB-240683 (anti-IL-4 Mab), BIIL-284, APC- 2059. budesonide + formoterol. Bay-16-9996 (IL-4 antagonist), beclometasone. GW- 328267, VLA-4 antagonists, 4-hydroxy-1-niethyJ-3-cctyloxy-7-sinapirioylamino-2(1H)- quinolinone O"A-270), CpG-7909 (ProMune), DNK-333A (Pharmaprojects No. 6070), AWD-12-281, LM-1507 (LM-1484). formoterol. MOL-6131, cathepsin S inhibitors. CS-615, ibudilast, 2-(N-(4-(4-Chlorophenylsulfonylamino)butyl)-N-{3-{2-{4- cydobutylthiazol-2-yl)ethyl)berizyl}sutfamoyI}benzoic acid (S-36527), and 2-{N-{4-{4- Chk>rophenylsulfonylamino)butyl)-N-{3-(4HSopropylthiazol-2- yl)methyloxy)benzyl}sulfamoyl}benzoic acid (S-36496). This invention also comprises pharmaceutical compositions comprising a pharmaceutically effective amount of a compound of this invention, or a pharmaceutically acceptable salt form thereof, and one or more pharmaceutically acceptable earners or excipients. Compounds of the present invention may be used in a pharmaceutical composition when combined with a pharmaceutically acceptable carrier. Such a composition may also contain (in addition to a compound or compounds of the present invention and a carrier) diluents, fillers, salts, buffers, stabilizers, solubilizers. and other materials weH known in the art The term "pharmaceutically acceptable" means a non-toxic material that does not interfere with the effectiveness of the biological activity of the active ingredients). The characteristics of the carrier will depend on the route of administration. The pharmaceutical composition may further contain other anti-inflammatory agents. Such additional factors and/or agents may be included in the pharmaceutical composition to produce a synergistic effect with compounds of the present invention, or to minimize side effects caused by the compound of the present invention. The pharmaceutical composition of the invention may be in the form of a liposome in which compounds of the present invention are combined, in addition to other pharmaceutically acceptable carriers, with amphipathic agents such as lipids which exist in aggregated form as micelles, insoluble monolayers, liquid crystals, or lamellar layers in aqueous solution. Suitable lipids for fiposomal formulation include, without limitation, monogrycerides, diglycerides, sulfatides. lysotecithin, phospholipids, saponin, bite acids, and the like. Preparation of such liposomal formulations is within the level of skill in the art, as disclosed, for example, in U.S. Patent No. 4,235,871; U.S. Patent No. 4,501,728; U.S. Patent No. 4,837,028; and U.S. Patent No. 4.737,323, all of which are incorporated herein by reference. As used herein, the terms "pharmaceutically effective amount" or "therapeuticalry effective amount" as used herein means the total amount of each active component of the pharmaceutical composition or method that is sufficient to show a meaningful patient benefit, i.e., treatment, healing, prevention, inhibition or amelioration of a physiological response or condition, such as an inflammatory condition or pain, or an increase in rate of treatment, healing, prevention, inhibition or amelioration of such conditions. When applied to an individual active ingredient, administered alone, the term refers to that ingredient alone. When applied to a combination, the term refers to combined amounts of the active ingredients that result in the therapeutic effect, whether administered in combination, serially or simultaneously. Each of the methods of treatment or use of the present invention, as described herein, comprises administering to a mammal in need of such treatment or use a pharmaceuticaHy or therapeuticafly effective amount of a compound of the present invention, or a pharmaceuticaBy acceptable salt form thereof. Compounds of the present invention may be administered in accordance with the method of the invention either alone or in combination with other therapies such as treatments employing other anti-inflammatory agents, cytokines, lymphokines or other hematopoietic factors. When co-administered with one or more other anti- inflammatory agents, cytokines, lymphokines or other hematopoietic factors, compounds of the present invention may be administered either simultaneously with the other anti-inflammatory agent(s), cytokine(s), rymphokine(s), other hematopoietic factors), thrombolytic or antMhrombotic factors, or sequentially. If administered sequentially, the attending physician will decide on the appropriate sequence of administering compounds of the present invention in combination with other anti- inflammatory agent(s), cytokine(s), lymphokir»e(s), other hematopoietic factors), thrombolytic or anti-thrombotic factors. Administration of compounds of the present invention used in the pharmaceutical composition or to practice the method of the present invention can be earned out in a variety of conventional ways, such as oral ingestion, inhalation, or cutaneous, subcutaneous, or intravenous injection. When a therapeuticaHy effective amount of compounds of the present invention is administered orally, compounds of the present invention will be in the forrr. of a tablet, capsule, powder, solution or elixir. When administered in tablet form, the pharmaceutical composition of the invention may additionally contain a solid carrier such as a gelatin or an adjuvant The tablet, capsule, and powder contain from about 5 to 95% compound of the present invention, and preferably from about 25 to 90% compound of the present invention. When administered in liquid form, a liquid carrier such as water, petroleum, oils of animal or plant origin such as peanut oil, mineral oils, phospnolipids, tweens, triglycerides, including medium chain triglycerides, soybean oil, or sesame oil, or synthetic oils may be added. The liquid form of the pharmaceutical composition may further contain physiological saline solution, dextrose or other saccharide solution, or glycols such as ethylene glycol, propytene glycol or polyethylene glycol. When administered in liquid form, the pharmaceutical composition contains from about 0.5 to 90% by weight of compound of the present invention, and preferably from about 1 to 50% compound of the present invention. When a therapeutically effective amount of compounds of the present invention is administered by intravenous, cutaneous or subcutaneous injection, compounds of the present invention will be in the form of a pyrogen-free, parenterally acceptable aqueous solution. The preparation of such parenterally acceptable protein solutions, having due regard to pH, isotonictty, stability, and the like, is within the skill in the art A preferred pharmaceutical composition for intravenous, cutaneous, or subcutaneous injection should contain, in addition to compounds of the present invention, an isotonic vehicle such as Sodium Chloride Injection, Ringer's Injection, Dextrose Injection, Dextrose and Sodium Chloride Injection, Lactated Ringer's Injection, or other vehicle as known in the art. The pharmaceutical composition of the present invention may also contain stabilizers, preservatives, buffers, antioxidants, or other additives known to those of skill in the art The amount of compound(s) of the present invention in the pharmaceutical composition of the present invention will depend upon the nature and seventy of the condition being treated, and on the nature of prior treatments the patient has undergone. Ultimately, the attending physician wfll decide the amount of compound of the present invention with which to treat each individual patient Initially, the attending physician will administer low doses of compound of the present invention and observe the patient's response. Larger doses of compounds of the present invention may be administered until the optimal therapeutic effect is obtained for the patient, and at that point the dosage is not increased further. It is contemplated that the various pharmaceutical compositions used to practice the method of the present invention should contain about 0.1 ug to about 100 mg (preferably about .1 mg to about 50 mg, more preferably about 1 mg to about 2 mg) of compound of the present invention per kg body weight The duration of intravenous therapy using the pharmaceutical composition of the present invention will vary, depending on the severity of the disease being treated and the condition and potential idiosyncratic response of each individual patient. It is contemplated that the duration of each application of the compounds of the present invention will be in the range of 12 to 24 hours of continuous intravenous administration. Ultimately the attending physician will decide on the appropriate duration of intravenous therapy using the pharmaceutical composition of the present invention. A preferred lipid based oral formulation of this invention has been prepared by blending 50% PHOSOLO 53MCT (American Lecithin Company). 5% Polysorbate 80, 15% LABRAS0L6 Caprylocaproyl macrogol-8 glycerides (Gattefosse Corp.), 15% Propylene Carbonate and 15% active CPLA2 inhibiting compound(s) of this invention, each percentage listed being by weight. This invention also provides a process for preparing compounds of this ionvention, which comprises include one of the following: a) reacting a compound of formula A wherein X2) n, n,, n2,n3, n4, R, R2. R3 and R4 are as defined herein; and R' is NH2, with a suifonyl haiide of formula hal-SO2CH2)n2X1R1 wherein hal is a suitable halogen and n2, X1, and R1 are as defined herein, to give a corresponding compound of formula (I), or b) hydrolyzing a compound of formula I wherein R2 comprises an ester to provide the corresponding acid, or c) converting a compound of formula I having a reactive substitutent to a different compound of formula I, or d) reacting a compound of formula A wherein X2, n, n,, n2, n3 n4, R, R2, R3 and R4 are as defined herein; and R1 is -NH-S(O)2-(CH2)nrhal0 or -NH-S(O)2-CH=CH2 and n2 is as defined herein, with a nucleophile of formula: HX1R1 wherein X1 and R1 are as defined herein, to give a corresponding compound of formula (I); or e) alkylating a compound of formula wherein R, R1, R3, R4, X1 and n2 are as defined herein.with an aldehyde or acetal of formula wherein R2 X2 and n3 are as defined herein, or f) reacting a 3-formyl indole of formula wherein PRT is a protecting group, R, R1, R3, R,. X, and n2- are as defined herein, with an amine of formula: RaHN-CH2R2 wherein Ra is hydrogen or C1-C3 alkyl and R2 is as defined herein, to give a compound of formula I wherein X2 is -RaN-CH2-, or g) reacting an alkyl amine of formula wherein hal is a suitable halogen and R, R3, and R4 are as defined herein, with an alkyne of formula wherein R1, R2, X1, and X2 are as defined herein to give a compound of formula (I), or h) reacting a halide of formula wherein halo is a suitable halogen and R, R2, R3, R4, X2, n1 and n3 are as defined herein.with a sulfonamide of formula wherein R1, X1 and n2 are as defined herein to give a corresponding compound of formula (I). This invention also provides intermediates useful for preparing the compounds of formula (I), which intermediates include those having the formula (A): wherein X2. n, n1, n2, n3, n4, R, R2, R3 and R4 are as defined above; and R' is selected from the group consisting of-OH, -NH-S(0)2-(CH2)n2-halo, -NH-S(O)2- CH=CH2, -NH2, or a protected form of -NH2; Exemplified intermediates have formula (B): wherein n, n1, n2, n3, n4, R', R, R3 and R4 are as defined above; and R6 and R9 are independently selected from H, halogen, -CN, -CHO, -CF3, -OCF3, - OH. -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(d- Cealkyl), -N-C(OHC1-C6 alkyl), or -NO2; R7 represents -(0H2)rA-CO2H an ester form of-(CH2)n4-CO2H, or a pharmaceutically acceptable acid mimic or mimetic; and X is a finking group selected from the group consisting of -O-, -CH2-, -SO2-, -NH-, and -N(C1-C6Valkyl)-. A preferred embodiment of the intermediates of this invention comprises benzhydryl indote compounds of formula (C): wherein: R; R3, R4, R74, X, n1 n2 and n4 are as defined above; and, R10, R11, R12. R13, R14 and R15 are each independently selected from H, halogen, -CN, -CHO, -CFS, -OCF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 allcyfe, - NH(C1-C6 alkyi), -N-C(OHC1-C6 alkyf), -NO* or a 5- or 6-membered heterocyclic or heteroaromatic ring containing 1 or 2 heteroatoms selected from O, Nor S. The term halogen or halo is used in this specification to refer to F..CI, Brand I. Preferred halogen atoms in the R' group -NH-S(OMCH2)n2-haIo include bromine and chlorine. Preferred ester forms of the compounds of formula C wherein R7 is -(CH2W CO2H, are the C1-C6, alkyl esters, including straigrit, branched and cyclic alkyi groups, and benzyl esters. Commercially available and art recognized amine protecting groups are useful to form the protected forms of the -(CH2)n1-NH2 groups described above. These include those represented by the formulae below, wherein the number of carbon atoms in the chain are merely presented for illustration and do not limit the number of carbon atoms in the corresponding carbon chains of this invention. Other non-limiting examples of amine protecting groups useful with the compounds of this invention include, but are not limited to, the following: 1) amide types such as formyl, acetyl, chloroacetyl, trichloroacetyl, o- nitrophenytacetyl, o-n'itrophenoxyacetyl, trifluoroacetyl, acetoacetyl, phthalyl, and p- toluenesuffonyl; 2) aromatic carbamate types such as benzytoxycarbonyl (CBZ), and benzyl substituted one or more time with with alkyl, cyano, nrtro, chloro, fluoro, bromo, and methoxy; diphenyimethyl, 1-(p-biphenyO-1- methylethyl, 9-fluorenylmethyl (Fmoc), 2- phenylethyl, and dnnamyl groups; 3) aliphatic carbamate types such as tert- butytoxycarbonyl (Boc), ethyl, diisopropylmethyl, allyl, vinyl, t-amyl, diisopropylmethyl, and isobutyl; 4) cyclic alkyl carbamate types such as cyclopentyl, cyclohexyl, cydopropytmethyt, and adamantyl; 5) alkyl type amine protecting groups such as triphenylmethyi (trityl) and benzyl; 6) trialkylsilane groups such as trimethylsilane, triethylsilane, triisopropylsilane, tri-t-butyteilane, triphenytsilane, tritolylsilane, trimesitytsilane, methyldiphenylsilane, dinaphthylmethylsilane, bis(dipheny1)methytsilane, etc.; and 7) thiol containing types of protecting groups, such as phenylthiocarbonyl and dithiasuctinoyl protecting groups. Other preferred amine protecting groups for use with this invention are ethoxycarbonyl groups, acyl groups, including 4-chlorobutyryl isobutyryl, o- nitrocinnamoyl, picolinoyi, acylisothiocyanate, aminocaproyl, benzoyl and the like, and acytoxy groups including methoxycarbonyl, 9- fluorenylmethoxycarbonyl, 2,2,2- trifluoroethoxycarbonyl, 2- trimethyteilylethxoy carbonyl, vinyloxycarbonyl, allytoxycarbonyl, 1,1-dimethylpropynytoxycarbonyl, p-nitrobenzyloxycarbony, 2,4- dichlorobenzyloxycarbonyt, and the like. Pharmaceutically acceptable acid mimics or mimetics which may appear at R7 include those selected from the formulae: wherein R, is selected from -CF3, -CH3, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -CF3, halogen, -OH, or-COOH; Rb, is selected from -CF3, -CH3 -NH2, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -CF3, halogen, -OH, or -COOH; and Re is selected from -CF3 or C1,- C, alkyl. Another preferred embodiment of the compounds of this invention is represented by formula D: wherein each of the variables R3, R4, R8 through R15, X and n4 are as defined above. A particularly preferred embodiment are compounds of formula (D) in which R10 through R1S are each hydrogen. Another preferred embodiment of the intermediates of this invention are those of formula E wherein each of the variables R3 through R15, and X are as defined above. A particularly preferred embodiment of this invention are compounds of formula E in which R10 through R15 are each hydrogen. Among the most preferred intermediates of the present invention are the compounds below which are designated Intermediates No. 1,2 and 3. An illustrative method for making these intermediates is also shown. These examples of highly preferred compounds and methods should not be construed as limiting the scope of the invention. Preparation of intermediates is illustrated in the following: Intermediate No. 1 4-{2-p-(2-Amino-ethyl)-1-benzyhydryl-5-chloro-1H-indol-3-yI]- ethanesulfonyfl)-benzoic acid methyl ester. Step 1:2-Bromo-4-chloroanililine(1.0eq) was dissolved in CH2Cl2(0.25M), then triethyiamine and triflouroaoetyl anhydride(1.1eq each) were added. The resulting mixture was stirred at room temperature for 1 hour. Solvent was then stripped-off from the reaction mixture, and the residue was purified by flash chromatography with dichloromethane as eluent to give the described product in 97% yield. m/z(M-H)-300.0. Step 2: N-(2-Bromo-4-hlorophenyl)-2,2,2-trifluoroacetamide(step 1,1.Oeq) was mixed with 3-butyn-1-ol(2.0eq), dichlorobis(triphenylphosphine)palladium(ll) (2.5%eq), triethyiamlne(3.0eq), Cul(5%eq) in DMF(0.2M) in a sealed vessel under N2 and heated to 120°C for 4 hours. The reaction mixture was then diluted with ethyl acetate, washed with brine and dried over Na2SO4. Furthermore, evaporate the solvent and the residue was purified by flash column chromatography with 2% MeOH/CHzCb to give the described 2-(5-Chloro-1H-indol-2-yl)ethanol in 67% yield. m/z(M-H)194.09 Step 3:2-{5-chloro-1H-indol-2-yl)ethanol (1eq) was added to a solution (under N2) containing terf-Butyldiphenylchlorosilane (1.2eq), imidazole (2.5eq). and OMF (1.8M). The reaction was stirred overnight. Quenched with NaHCO3 (aq) and extracted with a Et2-O/EtOAc mixture. The organic layer was washed with water and brine and dried over sodium sulfate. Purified with silica gel column and 1:4 Hexane/CHzClz as eluent Obtained 2-([tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro- 1H-indo(e (yellow oil) in 98% yield. Step 4: Methyl 4-{(2-oxoethyl)sulfanyl]benzoate (3.7eq) was added to a solution containing 2-({[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1H-indole (1eq), TFA (3eq), and 1.2-dichloroethane (0.1M) at 0°C under N2. Then EfeSiH (12eq) was added and the reaction was allowed to return to room temperature and stirred overnight. Quenched reaction with NaHCO3(aq) and extracted with EtOAc and washed with brine and dried over sodium sulfate. Purified with silica gel column and 1:5 EtOAc/Hexane as eluent Obtained methyl 4-({2-{2-{2-{{tert- butyl(dipheny))silyl]oxy}ethyl)-5-chloro-1 H-indol-3-yl]ethyl}surranyl)benzoate (yellow solid) in 79% yield. Step 5: Methyl 4-({2-{2-(2-{Itert-butyl(dipheny1)silytloxy}ethyl)-5-chloro-1H- indol-3-y1]ethyf}sulfanyl)benzoate (1eq) was added to a suspension of NaH (1.1 eq) in DMF (0.37M) at 0°C under N2. After 30 minutes PtfcCHBr (1.8eq) was added and the reaction was warmed to room temperature. After 3 hours the reaction was quenched with NH4Cl(aq) and extracted with EtOAc/EtzO mix and washed with water and brine and dried over sodium sulfate. Purified with silica gel column and 1:5 EtOAc/Hexane. Obtained methyl 3-{4-({2-{1-benzhydryl-2-(2-{Itert-butyl(diphenyl)sitynoxy}ethy1)-5- chloro-1H-indol-3-yl]ethyl}8ulfanyl)phenyl]benzoate (yellow gum) in 65% yield. Step 6: NMO (4eq) was added to a solution/suspension containing methyl 3- [4^{2^1-benzhydryl-2-(2-{[tert-butyl(diphenyl)sily yl]ethyl}surranyl)phenyqbenzoate (1eq), ACN (0.1M), and molecular sieves (1g/mmole of benzoate) under N2. After 10 minutes TPAP (0.12eq) was added and the mixture was heated to 40°C. After 1.5 hours the reaction was cooled and filtered and the filtrate was collected. Purified with silica gel column and 1:5 EtOAc/Hexane. Obtained methyl 3-{4-{{2-[1-benzriydryl-2-(2-{(tert-buty1(diphenyl)silyl]oxy}ethyO-5- chloro-1H-indol-3-yl}ethyI}sutfonyl)phenyt]benzoate (white solid) in 71% yield. Step 7: Tetrabutylammonium fluoride (1M in THF) (1.2eq) was added to a solution of methyl 3-[4-{{2-{1-benzhydryJ-2-(2-{Itert-butyl(diphenyi)8ilylloxy}ethyl)-5- chloro-1H-indol-3-yqethyl}sulfonyl)phenyl]benzoate (1eq) and THF (0.1M) at 0°C under N2- Warmed reaction to room temperature and after 1 hour quenched with NH4Cl(aq). Extracted with EtOAc and washed with brine and dried over sodium sulfate. Purified with silica gel column and 1:9 EtOAc/CH2CI2. Obtained methyl 3-[4- ({2-[1-benzhydryl-5-chloro-2-(2-hydroxyethyl)-1HHndol-3- yf]ethyl}sulfonyl)pnenyqbenzoate (white solid) in 86% yield. Step 8: CH3SO2CI (2eq) and EtsN (2.5eq) were added to a solution of methyl 3-[4-({2-[1-benzhydryl-5-chloro-2-(2-hydroxyethyl)-1H-ndol-3-yl]ethyl)sulfonyl)phenyl benzoate (1eq) in CH2a2 (0.02M) at 0°C under N2. After 1 hour the reaction was warmed to room temperature. After an additional hour water was added and extracted with CH2CI2 and washed with brine and dried over sodium sulfate. Removed solvent to obtain methyl 3-(4-{[2-(1-benzhydiyl-5-chloro-2-{2- [(methylsulfonyl)oxy]ethy)}-1 H-indol-3-yl)ethyflsulfonyf}phenyl)benzoate (light-yellow solid) in 99% yield. Step 9: Methyl 3-(4-{[2-(1-benzhydryl-5-chloro-2-{2- [(methy1sulfonyl)oxy]ethyl}-1 H-indo»-3-yl)ethytlsulfonyf}phenyl)benzoate (1eq), sodium azide (5eq), and DMF (0.05M) were placed together under N2 and heated to 60°C. After 1 hour the reaction was cooled and water was added. Extracted with EtOAc/EfeO mix and washed with water and brine and dried over sodium sulfate. Removed solvent to obtain methyl 3-{4-{2-{2-{2-azidoethyl)-1-benzhydryt-5-chloro- 1H-indol-3-yl]ethyl}sulfony0pnenynbenzoate (light-yellow solid) in 99% yield. Step 10: Methyl 3-[4-({2[-(2-azidoethyl)-1-benzhydry1-5-chloro-1H-indol-3- yl]ethyf}sulfonyl)phenyl]benzoate (1eq), PPh, (2eq), and THF (0.1M) were placed together under N2 and stirred overnight Water (1mL/1mmote benzoate) was added and reaction was again stirred overnight The solution was concentrated and purified with silica gel column and 3:1 EtOAc/Hexane followed by 5% MeOH in CHjCfe. Obtained methyl 3-{4-({2-{2-(2-aminoethyO-1-benzhydryl-5-chloro-1H-indol-3- yl}ethyt}sulfony1)phenyl]benzoate (light-yellow solid) in 99% yield. Synthesis of Intermediate No. 1 is also described below in Example 135, Steps 1-8. This intermediate could also be synthesized by method K or method M, which are set forth below. Intermediate No. 2 4-{2-[2-(2-Amino-ethyl)-benzyhydryl-5-chloro-1H-indol-3-yl]-ethoxy}- bonzoic acid methyl ester. Step 1: To 4-hydroxy-benzoic add methyl ester (1.0 eq) in DMF (0.83 M) was added K2CO3 (2.0 eq) followed by 2-bromo-1,1-diethoxy-ethane and the reaction mixture was stirred at 110 "C for 2 days. TLC showed a new spot. The reaction mixture was dHuted with ethyl acetate, washed with 1N NaOH, water, and brine, dried over sodium sulfate, and solvent was removed to afford desired product in 84 % yield. This material was used in the next step without further purification. Step 2: To the above product (1.0 eq) and 5-chloro-2-methyl indote (1.0 eq) in CH2CI2 (0.12 M) was added triethylsilane (3.0 eq) followed by trifluoroacetic add (3.0 eq). After being stirred overnight at room temperature, added water and trifluroacetic acid (1.0 eq) to the reaction mixture, stirred at room temperature for two days, diluted with CH2Cl2, washed with 1N NaOH, water, brine, dried over sodium sulfate. Trituration of the material with CH2Cl2 and hexanes afforded the C3 alkylated indote in 92% yield Step 3: To the indote from above (1.0 eq) in DMF (0.36 M) at 25 'C was added NaH (1.2 eq, 60 % dispersion in oil), and the brown solution was stirred at 0 to •5 'C for 1 h and then compound bromodiphenylmethane was added (1.1 eq), and then the reaction mixture was stirred overnight. It was then quenched with water, diluted with ethyl acetate, washed with water and brine, dried over sodium sulfate and purified by column chromatography to yield 72 % of the desired product. Step 4: To the N-alkylated indoie from above (1.0 eq) in CCI4 (0.2 M) was added N-bromosucrinimide (2.0 eq) and a catalytic amount of benzoyl peroxide. The solution was heated to reflux for 3h, cooled to 25 *C, filtered, and the solid was washed with CCI4. The filtrate was concentrated to a foam, which was dried. The foam was dissolved in acetone, and Ag2CO, (1.1 eq.) was added followed by water and the reaction mixture was stirred overnight at room temperature. It was filtered and washed with acetone. The filtrate was concentrated to a residue, to which was added water. This mixture was extracted with ethyl acetate, washed with brine, dried over sodium sulfate and then chromatographic purification on the residue gave the desired product in 85 % yield. Alternatively the dibromide from the reaction with NBS could be poured into DMSO (10-20% concentration by weight) stirred for 30 minutes at room temperature. When the reaction was deemed complete it was poured into water and the resulting precipitate was isolated by filtration, the cake was washed with water and dried to yield an essentially quantitative yield. Step 5: To the above aldehyde (1.0 equiv) in CH3NO2 (0.2 M) was added ammonium acetate (4 equiv) and the resulting mixture was heated to reflux for 4 h. The reaction mixture was then diluted with EtOAc and washed with brine. The aqueous phase was extracted with EtOAc. The combined organic extracts were washed with brine, dried over sodium sulfate, and concentrated until an orange crystalline sofid precipitated. The mixture was refrigerated overnight and the nitroolefin (76% yield) was collected by filtration. Evaporation of the solution phase and purification of the residue by column chromatography (gradient elation 100% toluene ?1% EtOAc-toluene) afforded an additional amount of the nitroolefin (23% yield). Step 6: Zinc dust (20 equiv) was suspended in 5% aqueous HCI solution (8 M Zn/5% HCI). To this mixture was added HgCI2 (0.28 equiv). The mixture was shaken for 10 min, the aqueous phase was decanted and replaced with fresh 5% HCI, and again the mixture was shaken for 5 min and the aqueous phase was removed. The zinc-mercury amalgam thus generated was then added to a mixture of the nitroolefin (1.0 equiv) and cone. HCI (80 equiv) in THF (0.04 M nitroolefin/THF). The mixture was Maintained at a gentle reflux for 1 h. The formation of product was followed by TLC analysis. The mixture was cooled to room temperature and the solids were removed by filtration through Celite. Cone. NH4OH was added to the solution phase and the mixture was concentrated on the rotary evaporator. The residue was dissolved in CH2CI2 and cone. NH4OH. The aqueous phase was extracted with CH2CI2, and the organic phase was washed with brine, dried over sodium surfate, and concentrated. Purification by column chromatography afforded the desired product (65% yield). Synthesis of Intermediate No. 2 is also described in Example 1, Steps 1-6. This intermediate could also be synthesized using methods K, L, orM, as set forth below. Intermediate No. 3 4-{3-[2-Amino-thyl)-14)-benzyhydryl-5-chloro-1H-indol-3-yq-propyl}- benzoic acid methyl ester Step 1: A mixture of rnethyl-4-iodobenzoate (5.3g, 20.2 mmol). allyl alcohol (1.78g, 30.3 mmol), NaHCOj (4.24g, 50.5mmol), PdfOAc)2 (0.14g, 0.60mmol), (n- Bu)4NBr (6.55g, 20.2 mmol) and 4-A molecular Sieves (4.1g) in anhydrous DMF (69mL) was stirred at room temperature for 4 days. The reaction mixture was filtered through ceSte and the filtrate poured onto water and extracted with EtOAc. Organic layer was washed with brine, dried (Na2SO4), and concentrated under vaccum. Flash chromatography (silica gel, 10-20 % EtOAc-hexanes) gave 2.11g (85% based on the recovered starting material) of the desired 4-(3-Oxo-propyl)-benzoic acid methyl ester as a clear oil. Stop 2: To a solution of 5-chloro-2-methylindole (0.86g, 5.2mmol) and 4-(3- Oxo-propyO-benzoic add methyl ester (1.0g, 5.2mmol) in methylene chloride (50mL), was added TFA (1 J8g, 15.6mmol). followed by triethyisilane (1.81g, I5.6mmol). The reaction mixture was stirred overnight, quenched with sat NaHCOj solution (50mL), and the organic layer was washed with sat NaHCOs solution, water, brine, and dried (Na2SO4). Solvent was removed under reduced pressure, and the residue was purified by flash column chromatography with 10-20% EtOAc/hexanes to yield the desired product in 94% (1.67g) yield. Step 3: To a solution of the product from step 2 (1.66g, 4.86mmol) in DMF (20mL) was added NaH (60% in mineral oil, 0.24g, 5.83mmol) under N2 atmosphere. The mixture was stirred for 1h at room temperature, followed by the dropwise addition of benzhydryl bromide (1.8g, 7.29mmol) in DMF (SmL). This reaction mixture was stirred overnight at room temperature. Water (500mL) was added to reaction mixture, it was extracted with EtOAc, washed with brine, dried (Na2SO4), and concentrated under reduced pressure to a brown syrup, which was purified by silica- gel chromatography using 10% EtOAc/hexanes as eluent to isolate 4 as a white solid in 59%(1.47g)yield. Step 4: The product from above (1.46g, 2.87mmol) was dissolved in CCU (14.5mL), followed by the addition of NBS (1.02g, 5.73mmol) and benzoyl peroxide (2mg). The reaction mixture was heated to reflux for 1h (until afl the starting material disappeared). This mixture was cooled to room temperature, filtered and the solid was washed with CCU- The filtrate was evaporated to a brown residue, which was dissolved in acetone (40mL) and water (4mL), AgfiCh (1.75g, 3.16mmol) was then added to this solution and after being stirred overnight at room temperature, it was filtered through celrte, the solvent was evaporated under reduced pressure, and water was added to the residue. It was extracted with EtOAc, washed with brine, dried (Na2SO4), and evaporated to a syrup, which was purified by 10% EtOAc/hexanes to isolate the 2-formyl indote (1.13g) in 75% yield. Alternatively the dibromide from the reaction with NBS could be poured into DMSO (10-20% concentration by weight) and stirred for 30 minutes at room temperature. When the reaction was deemed complete it was poured into water and the resulting precipitate was" isolated by filtration, the cake was washed with water and dried to yield an essentially quantitative yield. Step 5: To a solution of the 2 formyl indote from above (0.52g, 1mmol) in CH3NO2 (6.2mL) was added NH4OAC (0.077g, 1mmoO, the mixture was heated to reflux for 1h, NH4OAc (0.077g, 1mmol) was then added, heating at reflux was continued for an additional 1h, NH4Oac (0.077g, 1mmol) was added again and the heating continued for further 1h. The reaction mixture was allowed to attain room temperature, EtOAc (50mL) was added, followed by the addition of 100mL water. The aqueous layer was extracted with EtOAc, and the combined organic layers were washed with brine, dried (Na2SO4), and evaporated to a yellow foam, which was subjected to chromatographic purification using 10% EtOAc/hexanes as an eluent to yield 6 as a yellow foam in 68% yield (0.38g). Stop 6: Zn(Hg) was made by adding HgCl2 (3.4g, 7.2 mmol) to a mixture of Zn-dust (34.68g, 530.35mmol) and 5% HCI (38mL) in a 100mL beaker, this mixture was stirred vigorously for 10 min. Aqueous phase was decanted and added 38mL of 5% HCI again and the mixture was stirred for 10 min. Aqueous phase was decanted. This solid was added to the vinyl nitro compound 6 (15g, 26.57mmol) in THF (660mL) and cone. HCI (64.5mL). This mixture was stirred at room temperature for 1h, then at reflux for 15 min. The reaction mixture was cooled to room temperature and filtered through celite. Aq. NH4OH solution (200mL) was added to the filtrate, stirred for 15 min and THF was removed under reduced pressure. The aqueous layer was extracted with CH2CI2, combined organic layer was washed with brine, dried (Na2SO4) and concentrated to a brown foam, which was purified by column chromatography by editing the column with CHCI9 in the beginning to remove non- polar impurities then with 2% MeOH/CHCI3 to isolate the desired amine in 46% yield Synthesis of Intermediate No. 3 is also described below in Example 42, Steps 1-6. This intermediate could also be formed using Methods J, K, or M, as set forth below. Intermediate No. 4 4-{2-[2-(2-Amino-thyl)-1-benzhydryl-5-chloro-1H-indol-3-yI]- ethylamino}-benzoic acid methyl ester Step 1: To a solution of 4-chloro-2-iodoaniiine (16.5 g, 65.1 mmol) in DMF (250 mL) at rt were added D-bromodiphenytmethane (21.5g, 84.6 mmoO and *Pr2NEt (23 mL, 130 mmol) and the reaction mixture was heated at 45 *C overnight After the volatile was removed under reduced pressure, the residue was dissolved in EtOAc, washed with water (3x) and brine and dried over MgSO4. Purification on SiCfe column chromoatography (hexanes to 5% EtOAc/hexanes) gave the desired BenzhydryH4- chtoro-2-iodo-phenyI)-amine (26.1 g, 97% yield) as a yellowish solid. Step 2: A mixture of benzhydryl-(4-chloro-2-iodo-pheny])-amine (26.1g, 62.2 mmol), PdCl2PPh3)2 (1.90 g, 2.67 mmol). Cut (1.2 g. 6.2 mmol), 3-butyn-1-ol, and EtsN (120 mL) was stirred at 45 *C for 20 hours. The reaction mixture was filtered through celite and rinsed with EtOAc. The filtrate was concentrated, redissolved in EtOAc, washed with water (3x) and brine, and dried over MgSO4. The crude 4-[2- (Benzhydryl-amino))-5-loro-phenyl}-but-3-yn-1-ol (25.5 g) was used in the next step directly without further purification. Step 3: A solution of the crude 4-[2-(berizhydryl-amino)-5-chloro-phenyl)-but-3-yn-1- ol (25.5 g) and Cul (2.7 g, 14.1 mmol) in DMF (200mL) was heated at 125 *C for 24 hours. The reaction mixture was filtered through celite and rinsed with EtOAc. The filtrate was concentrated, redissolved in EtOAc, washed with water (3x) and brine, and dried over MgSO4. Silica gel column chromatography (30% EtOAc/hexanes) yielded the desired 2-(1-Benzhydryl-5-chloro-1H-ndol-2-yl)-ethanol as a yellow solid (14.5 g, 73% over 2 steps). Step 4: To a solution of 2-(1-benzhydryl-5-chloro-1H-indol-2-yl)-ethanol (15.3 g, 42.3 mmol) in CH2CI2 (190 mL) at 0 °C were added imidazote (3.72g, 55.0 mmol) and TBDPSCI (13.2 mL, 50.8 mmol). After stirring at the same temperature for 1.5 hours, the reaction mixture was washed with cold water (3x) and brine, and dried over MgSO4. The crude silyl ether was used in the next step directly without further purification. Step 5: To a solution of the crude silyl ether in EtaO (200 mL) at 0 aC was added oxatyl chloride (4.84 mL, 55.5 mmol) dropwise. The reaction mixture was allowed to warm to rt and stirring continued for 4 hours before Et3N (35 mL) and MeOH (10 mL) were added. The mixture was washed with water, brine, and dried over MgSO4. The crude keto ester was used directly in the next step. Step 6: To the keto ester in THF (300 mL) was added BH3.Me2S (10 M, 36 mL) dropwise at rt and the reaction mixture was refluxed overnight. The mixture was cooled at 0 *C before NaOH (30%, 150 mL) was added and stirring continued for 30 min. THF was removed under reduced pressure and the reaction mixture was extracted with EtOAc. washed with water, brine, and dried over MgSO4. Purification on column chromatography (15 to 20% EtOAc/hexanes) yielded the desired product as a white solid (15.9 g, 24.7 mmol, 58% over 3 steps). Step 7: To a solution of oxatyl chloride (0.372 mL, 4.27 mmol) in CH2Cl2 (10 mL) at - 78 *C was added DMSO (0.661 mL. 9.31 mmol) dropwise. The reaction mixture was stirred at the same temperature for 5 min before a solution of 2-{1-benzhydryl-2-[2- (tert-butyl-diphenyl-sianyloxy)-ethyl (2.50 g, 3.88 mmol) in CH2Cl2 (8 mL) was introduced. After additional 40 min stirring, "Pr^Et (3.38 mL, 19.4 mmol) was added and the reaction was quenched with cold water (5 mL) and extracted with CH2CI2- The organic layer was dried over MgSO4 and evaporated. The crude {1-Benzhydryl-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5- chloro-1H-indot-3-yl}-acetakdehyde was used directly in the next step. Step 8: To a solution of the crude aldehyde (3.88 mmol) in 1,2-dichk)roethane (39 mL) at 0 *C were added methyl 4-aminobenzoate (645 mg, 4.27 mmol), acetic acid (1.33 mL), and NaBH(QAc)3. The reaction mixture was allowed to warm to rt overnight and quenched with cold NaHCO* An extractive workup furnished the desired 4-(2-{1-Benzhydryt-2-{2-(tert-butyl-diphenyl-silanyloxy)-ethyl}-5-chloro-1 H- indol-3-yl}-ethylamino)-benzoic acid methyl ester which was used directly in the next step without further purification. Step 9: To 4-2-1-benzhydryl-2-2-tert-butydiphenyl-silanyloxy)-ethyn-5-chloro-1H- indol-3-yl}-ethylamino)-benzoic acid methyl ester (3.88 mmol) in THF (25 mL) at 0 .C was added a mixture of HOAc:1M TBAF (in THF) (2.3 mL5.8 mL) and the reaction mixture was allowed to stir at rt for 18h. Extractive workup followed by trituration with 5%EtOAc/hex gave the desired 4-{2-{1-Benzhydryl-5-chloro-2-(2-liydroxy-ethyl)- 1 H-indol-3-yl]-ethylamino}-benzoic acid methyl ester with slight impurity as an off- white solid (92%, over 3 steps). Step 10: To a solution of 4-{2-{1-benzriydryl-5-criloro-2-(2-hydroxy-ethy1)-1H-indol-3- yl]-ethylamino}-benzoic acid methyl ester (1.64 g, 3.04 mmol) in CH2CI2 at 0 *C were added Et3N (0.636 mL, 4.56 mmol) and MsCl (0.282mL, 3.64 mmol). After stirring at the same temperature for 35 min, the reaction mixture was quenched with cold water. An extractive workup revealed the crude mesylate as an off-white solid (1.70 g, 90%). Step 11: A solution of the crude mesylate (1.70 g, 2.75 mmol) and NaN3 (89 mg, 13.8 mmol) in DMF (14 mL) was stirred at 80 *C for 6h. The reaction mixture was diluted with EtOAc and subjected to an aqueous workup followed by flash column chromatography to yield the desired 4-{2-{2-{2-A2»do-ethy1)-1-benzhydry1-5-chloro- 1H-indol-3-yl]-ethylamino}-benzoic acid methyl ester (813 mg, 52% yield). Step 12: To4-{2-p-(2-azido-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-y1]- ethylamino}-benzoic acid methyl ester (400 mg, 0.709 mmol) in THF (4 mL) at 0 C was added PhjP (223 mg, 0.851 mmol) in portions. The reaction mixture was stirred at rt for 11 h and 35 *C for 4h before water (50 uL) was added and stirring continued overnight The reaction mixture was diluted with EtOAc, dried with MgSO4 and purified by flash column chromatography (EtOAc to 20%MeOH/EtOAc with 1 % EfeN) to give the desired 4-(2-[2-(2-Amino-ethyl)-1-ben2hydryl-5-chloro-1H-indo)-3-yl]- ethylamino}-benzoic acid methyl ester (201 mg, 53 %) as a solid. Synthesis of Intermediate No. 4 is also described below in Example 142, Steps 1-12. Intermediate No. S 4-({2-{2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethyl)- methyl-aminoH)enzoic acid methyl ester Step 1: Crude {1-Benzhydryl-2-{2-(tert-butyl-diphenyl-sUanyloxyH5thyI]-5-chloro-1H- indol-3-yl}-acetaldehyde from Intermediate No. 4 synthesis Step 7 was treated with 4- Methylamino-benzoic acid methyl ester according to the procedure in Intermediate No. 4 step 8 to yield the desired 4-{(2-{1-Benzhydryt-2-{2-(tert-butyWipheny- sllanytoxy)-ethyl]-5-chloro-1H-indol)-ethyl]-methyl-amino]-benzoic acid methyl ester in 73% yield. Step 2: The title compound was prepared according to the procedure described for Intermedaite No 4 step 9. The crude 4-{{2-{1-Benzhydryl-5-chloro-2-(2-hydroxy- ethyl)-1H-indol-3-yI]-ethyl}-methyl-amino)-benzoic acid methyl ester was used in the next step directly without further purification. Step 3-6:4-{242-2-Azido-thyl-1-benzhydryt-5H-loro-1H-indol-3-yl]-ethyl-methyl- amino)-benzoic acid methyl ester was prepared according to the procedure described for intermediate No. 4 steps 10-12 in 61% (3 steps). Step 7: A solution of 4-({2-[2-(2-azido-ethyl)-1-benzhydryl-5chloro-1H-indol- 3-yl]-ethyl}-methyl-amino)-benzoic acid methyl ester (410 mg, 0.709 mmol) and 10% Pd/C (155mg) in MeOH:CH2Cl2 (= 7 mL1 mL) was stirred under H2 atmosphere (1 atm) for 2h15 min. The reaction mixture was filtered through celite and rinsed with MeOH and CH2CI2. Flash column chromatography (CH2CI2to 8% MeOH/CH2CI2 ) of the residue gave the desired 4-{{2-{2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol- 3-yl]-ethyi}-methyl-amino)-benzoic acid methyl ester in 78% yield (305 mg). Synthesis of Intermediate No. 5 is also described below in Example 146, Steps 1-7. The compounds of this invention may be used as intermediates in the synthesis of pnarmaceutically useful compounds of formula I, including those having having formula IA: wherein: X is a linking group selected from of -O-, -CHr. -SQr. -NH-, and -N(C1-C6-alkyl)-; Rio. R11. R12. R13. R14 and R15 are each independently selected from H, halogen, -CN, -CHO. -CF,, -OCFa, -OH, -C1-C6. alkyl. C1-C6, alkoxy, -NH2. -NfC1-C6* alkyl)2, - NH(Ct-Ce alkyl). -N-C(OHC1-C6 alkyl), -NO2, or a 5- or 6-membered heterocydic or heteroaromatic ring containing 1 or 2 heteroatoms selected from O, N or S; R8 and R9 are independently selected from H, halogen, -CN, -CHO, -CF3, -OCF3, - OH. -C1-C6 alky), C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(OHC1-C6 alcyl), or-NOa; R7 is the formula -(CH2)n4-CO2H or a pharmaceutically acceptable acid mimic or mimetic, as defined above; R3 and R4 are each as herein before defined n1 is an integer from 1 to 3; n2 is an integer from 0 to 4; X1 is selected from a chemical bond, -S-, -O-, -S(O)-, -S(O)r, -NH-, -NHC(O)-, -C=C- R16 is a ring moiety selected from C1-C6 alkyl, C1-C6 fluorinated alkyl. C1-C6 cydoalkyl, tetrahydropyranyl, camphoryl, adamantyl, CN, -N(C1-C6 alky1)2, phenyl, pyridinyl, pyrimidinyl, furyl, thienyl, naphthyl, morpholinyl, triazolyl, pyrazolyl, piperidinyl, pyrrolidinyl, imidazolyl, piperazinyl, thiazolidinyl, thiomorpholinyl, tetrazole, indole, benzoxazole, benzofuran, imidazolidine-2- thione, 7,7-dimethy1-bicydo[2.2.1}heptan-2-one or pyrrolyl groups, each optionally substituted by from 1 to 3, preferably 1 to 2, substituents independently selected from H, halogen, -CN, -CHO, -CFS, OH, -C-C, alkyl, C1-C6 alkoxy, -NH2. -N(C1-C6 alky)-, - NH(C1-C6 alkyl), -N-C(OHC1-C6 alkyl). -NO2. -SO-C1-C6, alkyl), -SO2NH2, -SO2H(C1-C3 alkyl), -SO2N(C1-C6 alkyl]2. OCF3.-COOH, -CH2COOH, -CH2-NCC1-C6 alkyl), -CH2-N(C1-C6 alkyl)2, -CH2-NH-, pyridine or or a phanmaceutically acceptable salt or ester form thereof. Among the more preferred ester forms of the compounds of formula (IA) wherein R7 is the formula -{CHzW-CC-H, are the C1-C68 alkyl esters, including straight, branched or cyclic alkyl groups, or benzyl esters. The compounds of the invention may be prepared by any one of the processes described herein. Where appropriate reactive moieties or sites can be protected during the reaction with suitable protecting agents which are then removed after the reaction is complete. Suitable reagents are well known in the art Compounds of formula I may be prepared by a process comprising reacting a compound of formula A wherein R' is NH2 with a sulfonyl haide of formula hal-SO2-(CH2)n2-R1, wherein hal is a suitable halogen, e.g. Cl and n2. X1t and R1 are as defined herein. This may suitably be performed under Diphasic conditions, e.g. using aqueous sodium bicarbonate/dichloromethane, or in an organic solvent with the addition of a hindered organic amine base. Compounds of formula I may also be prepared by a process comprising hydrolyzing a compound of formula I wherein R2 comprises an ester to provide the corresponding acid. This may suitably be performed under basic conditions with sodium hydroxide in water and methanol and THF at room temperature or at elevated temperature. Alternatively it may suitably be cleaved by treatment with sodium thiomethoxide in a solvent such as THF or DMF at elevated temperatures (e.g. 50°C - 100°C). Compounds of formula I may also be prepared by a process comprising converting a compound of formula I having a reactive substitutent to a different compound of formula I. E.g. a halo may be converted to the corresponding amine. This may suitably be performed using a base, an amine, a phosphine ligand and a palladium reagent Compounds of formula I may also be prepared by a process comprising reacting a compound of formula A wherein R' is -NH-S(OHCH2)n2-halo or -NH- S(O)rCH=CH2 and n2 is as defined herein, with a nudeophile of formula HX1R1, wherein X1 and R1 are as defined herein. This may suitably be performed using a suitable organic base, e.g. Hunigs base, and heating until the reaction is complete. Compounds of formula I may also be prepared by a process comprising alleviating a compound of formula wherein R, R1, R3, R4, X1 and n2- are as defined herein, with an aldehyde or acetal of formula wherein R2, X2 and n3- are as defined herein. This may suitably be performed under the action of a Bronsted or Lewis acid such as trifluoroacetic acid and a reducing agent such as triethylsilane. Compounds of formula I wherein X2 is -RaN-CHr may be prepared by a process comprising reacting a 3-formyl indote of formula wherein PRT is a protecting group, R, Ri, Rs, R4, X1 and n2 are as defined herein, with an amine of formula RgHN-ClVRs. wherein Ra is hydrogen or C1-C3 alkyl and R2 is as defined herein. This may suitably be performed in a reducing agent such as sodium triacetoxyborohydride and an add such as glacial acetic acid. Suitable protecting groups are wed known in the art. Compounds of formula I may also be prepared by a process comprising reacting an alkyl amine of formula wherein hal is a suitable halogen, e.g. I or Br, and R, R3, and R4 are as defined herein, with an alkyne of formula wherein R1. R2, X1, and X2 are as defined herein. This may suitably be performed under paladium catalyzed conditions in the presence of a chloride source, a base and with or without a phosphine. Compounds of formula I may also be prepared by a process comprising reacting a halide of formula wherein halo is a suitable halogen, e.g. Br, and R, R2, R3 R4, X2 and n3 are as defined herein, with a sulfonamide of formula wherein, R1, X1 and n2 are as defined herein. This may suitably be performed using a strong base such as NaH, nBuLi etc. This invention can be further understood by the following non-limiting specific examples illustrating the preparation of compounds of the invention. Method A The initial indole of Method A may be alkylated at the C3 position (the carbon atom at the 3-position of the indole moiety) with aldehydes or the corresponding acetals in the presence of a Lewis or Bronsted add, such as boron trifiouride etherate or trifluoroacetic acid. The indole nitrogen may then be alkylated by treatment with a strong base such as sodium bts(trimethylsilyl) amide, n-BuLJ, sodium hydride or potassium hydride in a solvent such as DMF, DMSO or THF followed by exposure to the appropriate alkyl halide. The resulting product can be treated with carbon tetrabromide in carbon tetrachloride and a catalytic amount of benzoyl peroxide to effect dibromination of the C2 methyl group. The dibromide can then either be stirred with silver carbonate in acetone water or poured into DMSO and stirred. Both of these procedures generate the aldehyde which is then subjected to the nitro aldol reaction with nitromethane and a catalytic amount of ammonium acetate at reflux. The resulting vinyl nitro intermediate is reduced to the amine upon treatment with zinc mercury amalgam in a mixture of THF and cone. HCL at reflux. This amine can then be treated with the requisite sulfonyl chloride under Diphasic conditions, aqueous sodium bicarbonate/ dichloromethane, or in organic solvent with the addition of a hindered organic amine base. The final hydrolysis was accomplished under basic conditions with sodium hydroxide in water and methanol and THF at room temperature or at elevated temperature. Alternatively it may be cleaved by treatment with sodium thiomethoxkte in a solvent such as THF or DMF at elevated temperatures (50'C - 100'C). This method was used in the synthesis of Examples 1-88,108-112, and 126-128. Method B Method B The initial halide of Method B is refluxed in aqueous sodium sulfite and a suitable cosolvent if necessary, such as alcohol, dioxane etc, for the required amount of time to form the desired sodium sulfonate. This intermediate was treated with thionyl chloride, phosphorous pentachloride or oxalyl chloride, in dichtoromethane with a small amount of OMF and stirred for several hours at room temperature until the sulfonyl chloride is formed. The thus formed sulfonyl chloride is then used crude in Method A. This method was used in the synthesis of Examples 1-88,108-112 and 126-128 when the sulfonyl chloride was not commercially available. chlofo-IH-indoi--vttethoxvibenzoic acid This synthesis is depicted in Method A. Step 1: To 4-hydroxy-benzoic acid methyl ester (1.0 eq) in DMF (0.83 M) was added K2CO3 (2.0 eq) followed by 2-bromo-1,1-diethoxy-ethane and the reaction mixture was stirred at 110°C for 2 days. TLC showed a new spot. The reaction mixture was diluted with ethyl acetate, washed with 1N NaOH, water, and brine, dried over sodium sulfate, and solvent was removed to afford desired product in 84% yield. This material was used in the next step without further purification. Step 2: To the above product (1.0 eq) and 5-chloro-2-methyl indole (1.0 eq) in CH2Cl2- (0.12 M) was added triethylsilane (3.0 eq) followed by trifluoroacetic acid (3.0 eq). After being stirred overnight at room temperature, added water and trifluroacetic acid (1.0 eq) to the reaction mixture, stirred at room temperature for two days, diluted with Cn2CI2, washed with 1N NaOH, water, brine, dried over sodium sulfate. Trituration of the material with CH2Cl2, and hexanes afforded the C3 alkylated indole in 92% yield Step 3: To the indole from above (1.0 eq) in DMF (0.36 M) at 25 *C was added NaH (1.2 eq, 60 % dispersion in oB), and the brown solution was stirred at 0 to -5 *C for 1 h and then compound bromodiphenylrnethane was added (1.1 eq), and then the reaction mixture was stirred overnight It was then quenched with water, diluted with ethyl acetate, washed with water and brine, dried over sodium sulfate and purified by column chromatography to yield 72 % of the desired product. Step 4: To the N-alkytated indole from above (1.0 eq) in CCI4 (0.2 M) was added N-bromosuccinimkte (2.0 eq) and a catalytic amount of benzoyl peroxide. The solution was heated to reflux for 3h, cooled to 25 °C, filtered, and the solid was washed with CCI4. The filtrate was concentrated to a foam, which was dried. The foam was dissolved in acetone, and Ag2CO, (1.1 eq.) was added followed by water and the reaction mixture was stirred overnight at room temperature. It was filtered and washed with acetone. The filtrate was concentrated to a residue, to which was added water. This mixture was extracted with ethyl acetate, washed with brine, dried over sodium suKate and then chromatographic purification on the residue gave the desired product in 85 % yield. Alternatively the dibromide from the reaction with NBS could be poured into DMSO (10-20% concentration by weight) stirred for 30 minutes at room temperature. When the reaction was deemed complete it was poured into water and the resulting precipitate was isolated by filtration, the cake was washed with water and dried to yield an essentially quantitative yield. Step 5: To the above aldehyde (1.0 equiv) in CH3NO2 (0.2 M) was added ammonium acetate (4 equiv) and the resulting mixture was heated to reflux for 4 h. The reaction mixture was then diluted with EtOAc and washed with brine. The aqueous phase was extracted with EtOAc. The combined organic extracts were washed with brine, dried over sodium sulfate, and concentrated until an orange crystalline solid precipitated. The mixture was refrigerated overnight and the nrtrootefin (76% yield) was collected by filtration. Evaporation of the solution phase and purification of the residue by column chromatography (gradient edition 100% toluene -» 1% EtOAo-toJuene) afforded an additional amount of the nitrooJefin (23% yield). Step 6: Zinc dust (20 equiv) was suspended in 5% aqueous HCI solution (8 M Zn/5%HCt). To this mixture was added HgCfe (0.28 equiv). The mixture was shaken for 10 min, the aqueous phase was decanted and replaced with fresh 5% HCI, and again the mixture was shaken for 5 min and the aqueous phase was removed. The zinc-mercury amalgam thus generated was then added to a mixture of the nitroolefin (1.0 equiv) and cone. HCI (80 equiv) in THF (0.04 M nitroolefin/THF). The mixture was maintained at a gentle reflux for 1 h. The formation of product was followed by TLC analysis. The mixture was cooled to room temperature and the solids were removed by filtration through Cellte. Cone. NH4OH was added to the solution phase and the mixture was concentrated on the rotary evaporator. The residue was dissolved in CH2Cl2 and cone. NH4OH. The aqueous phase was extracted with CH2Cl2 and the organic phase was washed with brine, dried over sodium sulfate, and concentrated. Purification by column chromatography afforded the desired product (65% yield). Step 7: To methyl 4-(2-{2-(2-aminoethyl)-1-benzhydryl-5-hloro-1H-indol-3- yl]ethoxy}benzoate (1.0 equiv) and sat NaHCO, (0.14 M) in CH2Cl2 (0.07 M) was added a-toluenesulfonyl chloride (10 equiv). After 1 h the mixture was poured into saturated sodium bicarbonate and extracted with CH2CI2. The combined organic phase was washed with brine, dried over sodium sulfate and purified by column chromatography (gradient elution using 20% EtOAc-hexanes ? 50% BOAc- hexanes) to afford 86% of the desired product Step 8: The resulting ester was hydrolyzed by stirring with 1N NaOH (5 equiv) in THF (0.07 M) and enough MeOH to produce a clear solution. The reaction was monitored by TLC (10% MeOH-CH2Cl2) for the disappearance of starting material. The mixture was heated in a 60 degrees C oil bath for 2 hour. The mixture was concentrated, diluted with H2O, and acidified to pH 2-4 using 1 M HCI. The aqueous phase was extracted with EtOAc and the organic phase was washed with brine, dried over sodium sulfate, and concentrated to afford the desired product in 92% yield. HRMS calc for [C-H.MaN2O6.S + HJ 679.2028 found 679.2031. Example 2:4-{2-(1-Benzhydryl-5-chloro-2-{2-[(isopropyfsulfonyl)- amlno]ethylH-indd-3-yf)ethoxy]benzoJc add Step 1: This compound was prepared from methyl 4-{2-I2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-vQethoxy}benzoate (Step 6, Example 1) and isopropyteulfonyl chloride according to the procedure in Example 1 Step 7 in 55% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 81% yield. HRMS calc for [C35H35CIN2O5.S+H] 631.2028 found 631.2029. Example 3:4-[2-(1-Benzhydryl-2-{2-{(butylsulfony1)amino]ethyl}-5- chloro-1H-Indol-3-yl)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryi-5-chlorD-1H-indoi-3-yi]ethoxy}benzoate (Step 6, Example 1) and 1- butanesutfonyf chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C35H.37CIN2O5.S + H] 645.2185 found 645.2185. Example 4:4-{2-1-Benzhydryl-5-hloro-2-(2-{[(1-methyl-1H-imidazol-4- yl)sulfdnyl]amino}ethylHH-indol-3-yl]ethoxy)benzoic acid Step 1: To methyl 4-242-2-aminoethy))-14)enzhydryt-5(*iloro-1H-indol-3- yi]ethoxy}benzoate (Step 6, Example 1) (1.0 equiv) and EtsN (3.0 equiv) or pyridine (3.0 equiv) in CH2CI2 (0.05 M) was added 1-methylimidazole-4-sulfonyl chloride (1.2 equiv). The reaction was monitored by TLC (10% MeOH-CH2Cl2) and was heated if necessary. After 30 min the mixture was poured into saturated sodium bicarbonate and extracted with CH2CI2. The combined organic phase was washed with brine, dried over sodium suffate and purified by column chromatography to afford 92% of the desired product Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 89% yield. HRMS calc for [C*,H.»CIN4O6.S + H] 669.1933 found 669.1932. Example 5:4-{2-[1-B«nzhydryl-2-(2-a(5-bromo-6-chloro-5- pyridinyl)surfonyl]amino}ethyf )-5-chloro-1 H-indol-3-yl]ethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydry»-5-chloro-1H-ffKlol-3-yllethoxy}ben2oate (Step 6, Example 1) and 3- bromc-2-chtoropyridine-5-siiffonyl chloride according to the procedure in Example 1 Step 7 in 74% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 98% yield. HRMS calc for [C35H.37CIN2O5.S + H] 778.0539 found 778.0544. Example 6:4-[2-(1-Benzhydry1-5-chloro-2-{2-l({[(1R)-7,7-dimethyl-2- oxobicyclop.2.1]hept-1-y1]methyl}5ulfonyl)amino]ethyl)-1H-lndol-3- yl)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-chtoro-1H-indol-3-yl]ethoxy}ben2oate (Steps, Example 1) and (1RM-)- 10-camphorsulfonyl chloride according to the procedure in Example 1 Step 7 in 77% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 94% yield. HRMS calc for [C42H43CIN2O6-.S + HJ 739.2603 found 739.26. Example 7:4-{2-{1-Benzhydry1-5-chloro-2-2. (a(methyisulfonyl)inethyr)urfonyI}amino)rthyfJ-1H-ndo»-3-yl}ethoxy)b©nzolc acid Step 1: This compound was prepared from methyl 4-{2-[2-(2-amrnoethyl)-1- benzhydn25-chIoro-1H-mdo(-3-yl]ethoxy}benzoate (Step6, Example 1) and (methanesudfonyl]methanesulfonyl chloride according to the procedure in Example 4 Stepi in 43% yield. Step 2: The ester intermediate was hydrolyzed according to Example 117 Step 2 to afford the title acid in 95% yield. HRMS calc for IC-HjjCINaOr.Sz + H] 681.1491 found 681.1489. Example 8:4-(2-(1-B«nzhydryl-5-chloro-2-p-({I2-(1- Mphthyl)ethyl]sulfonyl}amino)«thy1]-1H-lndot-3-yl}«thoxy)benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydry»-5-chk)ro-1H-mdol-3-yl)ethoxy}benzoate (Step6, Example 1) and 2-{1- naphthyl)ethanesulfonyl chloride according to the procedure Example 1 Step 7 in 60% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 100% yield. HRMS calc for {C44H39CIN2O5 + H] 743.2341 found 743.2338. Example 9:4-{2-{1-Benzhydryl-5-chloro-2-{2-{({2-nrtrobenzyi}- sulfonyl)amino]ethyl}-1H-lndol-3-yl)ethoxy]benzolc acid Step 1: This compound was prepared from methyl 4-[2-{2-(2-aminoethy()-1- benzhydryt-5-chloro-1H-indol-3-yI]ethoxy}benzoate (Step6, Example 1) and 2-nitro- a-toluenesuJfonyl chloride according to the procedure in Example 1 Step 7 in 82% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 85% yield. HRMS calc for [C-H34CIN3O7-.S + H] 724.1879 found 724.1877. Example 10:4-{2-{1-Benzhydryl-5-chloro-2-(2-{[(3,4- dlchlorobenzyl)surfonyl]amirio}-thyl)-1H-ndol-3--ethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-chloro-1 H-indol-3-yl]ethoxy}benzoate (Step6. Example 1) and [(3,4- dichtorophenyl]-methyfJsulfonyl chloride according to the procedure in Example 1 Step 7 in 82% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 86% yield. HRMS calc for [C39H33CIN2 O5.S + H] 747.1249 found 747.1249. Example 11:4-{2-{1-Benzhydryl-6-chloro-2-(2-{[(3,5- dichloit)benzyl)»ulfonyfJamlno)-ethy1).1H-ndol-3--ethoxy)berizoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryf-5-chloro-1H-indol-3-yllethoxy}benzoate (Step6, Example 1) and [(3,5- dichlorophenyl)-rnethyl)sulfonyl chloride according to the procedure in Example 1 Step 7 in 100% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 98% yield. HRMS calc for [CH-CI3Nz O5.S + H] 747.1249 found 747.1249. Example 12:4-2-1-Beuhydiyl-5-hloro-2-(2-({[(3-(trrfluoromethyl)- berizyl]sulfony1}-arnlno)ethyl]-1H-lridol-3-yf)ethoxy)berizolc acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyi)-1- benzhydryl-5-chloro-1H-indol-3-ynethoxy}benzoate (Step6, Example 1) and R3- (trifluorornethyl)-prienyl]rnethyl]su»fonyl chloride according to the procedure in Example 1 Step 7 in 74% yield. Step 2: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title acid in 86% yield. HRMS calc for [C40H34CIF3N2O5S + H] 747.1902 found 747.1904. Example 13:4-{2-1-enzhydryl-5-chloro-2-(2-({I(4-(trifluoromethyl)- benzyl]suH6nyl}-amno)ethyl]-1 H-indoJ-3-y1}ethoxy)benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydry-5-loro-1H-indol-3-yl]ethoxy}benzoate (Step6, Example 1) and R4- (trifluoromethyl)phenynmethyl]sutfonyl chloride according to the procedure in Example 1 Step 7 in 77% yield. Step 2: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title acid in 83% yield. HRMS calc for [C40H34CIF3N2O5S + H] 747.1902 found 747.1901. Example 14:4-(2-1-Benzhydryl-5-chloro-2-(2-{[(4-fluorobenzyl)- sulfonyfJ«nlno)ethyl)-1H-lndol-3-yl]ethoxy}benzoic add Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-cfiloro-1H-indol-3-y1]ethoxy}benzoate (Step6, Example 1) and [(4- fluorophenyl)methyl]sulfonyl chloride according to the procedure in Example 1 Step 7 Step 1 in 86% yield. Step 2: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title acid in 94% yield. HRMS calc for [C39H34CIFN2 O5S + H] 697.1934 found 697.1938. Example 15:4-{2-[1-Benzhydiyl-5-chloro-2-(2-{[(4- chlorobenzyl)sulfonyl]amino}-ethyl)-1 H4nde4-3-yl]etnoxy}berizoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- bert2-ydryl-5-k)ro-1H-irKlol-3-yl]ethoxy}benzoate (Step6, Example 1) and [(4- chloropheny(-)methylIsuHbnyl chloride according to the procedure in Example 1 Step 7 in 73% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 99% yield. HRMS calc for [CmHmCI- OsS + HJ 713.1638 found 713.1643. Example 16:2-(2-{[(2-Afninobenzyl)surfony0amino}othyl)-4-{2-{1- benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benrolc add Step 1: To methyl 4-2-1-benzhydrj4-5-chtoro-2-{2-{2-nitrobenzyl]benzyl}- sulfonyl)amino]ethyl}-1H-indo(-3-yl)ethoxy]ben2oate, Example 9, step 1, (1.0 equiv) in CH2CI2 (0.014 M) was added a mixture of tin(ll) chloride dihydrate (3.0 equiv) dissolved in concentrated HCI. After 16 h the mixture was bastfied (pH 10) with 3 N NaOH and extracted with CH2CI2. The combined organic phase was washed with brine, dried over sodium sulfate and purified by column chromatography (gradient elution using 20% EtOAc-hexanes -» 50% EtOAc-hexanes) to afford 83% of the desired product. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 83% yield. HRMS calc for [C39H35CIN3O6S + H] 694.2137 found 694.2136. Example 17:4-{2-[1-Benzhydryl-5-chloro-2-(2- {[(dimethylamlno)eulfonyfjamino}ethyl)-1 H-indol-3-yfJethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aminoethyl)-1- ben2ydryt-5-c*ik)rcKiHHndol-3-yr}ethoxy}benzoate (Step6, Example 1) and dimethylsurfamoyl chloride according to the procedure in Example 1 Step 7 in 49% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1to afford the title acid in 95% yield. HRMS calc for [C34H34CIN3O5S + H] 632.1981 found 632.1984. Example 18:4-{2-[1-Benzhydryl-5-chloro-2-(2-([(3,4- difluorobenzyl)sulfony1]amino}-ethyl)-1 H-indo-3-y!]ethoxy}benzoic acid Step 1: To 3,4-difluorobenzyl bromide (1.0 equiv) in H2O (0.74 M) was added sodium sulfite (1.1 equiv). The mixture was heated to reflux for 16 hours then cooled to room temperature. The white precipitate was tittered and dried to afford 95% of the sodium sulfonate intermediate. Step 2: To 3,4-difluorobenzyl sodium sulfonate (7.6 equiv) in CH2CI2 (0.76 M) was added DMF (5.6 equiv) and SOCI2 (30 equiv). After 1 h the mixture was concentrated and azeotroped with toluene. The residue was suspended in CH2CI2 (0.38 M) and methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryf-5-chloro-1H-endol-3- yl]ethoxy}benzoate (Step6, Example 1) (1.0 equiv) and sat. NaHCO, (0.76 M) were added. After 1 h the mixture was poured into H2O and extracted with CH2CI2. The combined organic phase was washed with brine, dried over sodium surrate and purified by column chromatography (gradient edition using 20% EtOAc-hexanes -» 40% EtOAc-hexanes) to afford 94% of the methyl ester intermediate. Step 3: The methyl ester was hydrolyzed according to Step 8 Example 1 to afford the title arid in 93% yield. HRMS calc for [C39H53CIF2N2 OSS + H] 715.184 found 715.1843. Example 19:4-{2-{1-benzhydrv1-5K-loro-2-(2-{I(2- naphthyhTWthyl)surfony0amlrM)}ethylHH-ndol-3-yflethoxy}benzolc acid Stepi: The sulfonyl chloride intermediate was prepared from 2- (bromomethyl)naphthalene according to the procedure in Example 18 Step 1-2 in 34% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4--2-inoethvlH-benzhyl]Yyl-5-chloro-1- (Step6, Example 1) according to the procedure in Example 1 Step 7 in 58% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 74% yield. HRMS calc for [C43H37ClN2 O6S + H] 729.2185 found 729.2189. Example 20: 3-({[(2-{1-benzhydryl-3-[2-(4-carboxyphenoxy)ethyl]-5- chloro-1H-indol-2-yl}ethyl)amino]suffonvr}methyl)benzoic acid Step 1: The sulfbnyl chloride intermediate was prepared from methyl 3- (bromomethyt)benzoate according to the procedure in Example 18 Step 1-2. Step 2: The methyl ester was prepared from the sutfonyl chloride and methyl 4-2-2-(2-amino)ethyl-1-benzhydryi-5-chloro-1HHndol-3-yl]ethoxy}benzoate (Step6, Example 1) according to the procedure in Example 1 Step 7 in 23% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title diacid in 93% yield. HRMS calc for [C40H35CIN2O2S* H] 723.1926 found 723.1932 Example 21:4-(2-1-bwzhydry1-5(hloro-2-p-(a(E)-2- phenylethenyl]suHbnyl}amino)ethyri H-indol-3-yl}ethoxy)benzoic acid Step 1: To the methyl 4-{2-{2-{2-aminoethyl)-1-benzhydry)-5-cWoro-1H-indol- 3-yf]ethoxy}benzoate (Step6, Example 1) was added trans-a-styrenesuffbnyl chloride according to the procedure in Example 1 Step 7 to generate the product in 66% yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 98% yield. HRMS calc for [C40H35CIN2 OSS + H] 691.2028 found 691.2034. Example 22:4-{2-[1-benzhydry]-5-chloro-2-(2- {[(trifluorc-ethyl)sulfonyt]amlno)rthylHH-ndo(-3-yrjethoxy}benzolc acid Step 1: To the methyl 4-{2-{2-{2-aminoethyl]-1-benzhydryl-5-chk)ro-1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added trifluoromethylsulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 49% yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 100% yield. HRMS calc for {C35H25,CIF3N2 O*S + H] 657.1432 found 657.1435. Example 23:4-[2-(1-benzhydry1-5-chloro-2-{2- [(cyctopropylsulfonyl)amino]ethyl}-1 H-lndol-3-y1)ethoxy]benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyi)-1-benzhydryJ-5-chloro-1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added cyclopropanesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 75% yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 84% yield. HRMS calc for [C-H-CINj O5S + H] 629.1872 found 629.1874. Example 24:4-(2-{1-benzhydryl-2-[2-({I3,5- bis(trifluoroniethy1)benzyrj8ulfonyr)arnino)ethyl]-5-chlofo-1H-lndol-3- yl}ethoxy)benzoic acid Step 1: To the methyl 4-42-2-eminoemyl)-1-berizhydryl-5-cNoro-1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added 3,5- bis(trifliioromethyl)benzylsulfonyl according to the procedure in Example 1 Step 7 to generate the product in 79% yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 81% yield. HRMS calc for [C4iH»CIF6N2 O8S + H] 815.1776 found 815.1776. Example 25:2-{[(2-{1-benzhydryl-3-I2-(4-carboxyphenoxy)ethyl]-5- chloro-1H-indol-2-y1}ethyl)amino]surfonyf}benzolc acid Step 1: To the methyl 4--2K2--mirx»thy1)-14)enzhydryl-5-chlofO-imncJol- 3-yfJethoxy}benzoate (Step6. Example 1) was added methyl (2- chlorosulfonyl)benzoate according to the procedure 'm Example 1 Step 7 to generate the product in 100% yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 61% yield. HRMS calc for [C*H3,CIN2 O7S + H] 709.177 found 709.1772. Example 26:4-p-(1-benzhydryl-chloro-2-(2-[(2- naphthylsulfonyl)amino]ethyf}-1H-{ndol-3-yl)ethoxy]benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-ben2hydryl-5-chloro-1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added 2-naphthalenesulfohyl chloride according to the procedure in Example 1 Step 7 to generate the product in 53% yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 100% yield. HRMS calc for [C42H35CIN2 O6S + H] 715.2028 found 715.2034. Example 27:4-{2-{1-benzhydryl-5-chloro-2-(2-tt(3,5- dichloropheny1)8ulfonyl]amirK)}ethyl)-1H-indol-3-yl]ethoxy}bonzoicacid Step 1: To the methyl 4-{2-{2-{2-aminoethyI)-1-benzhydryJ-5-c-loro-1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added 3,5-dichlorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 60% yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 88% yield. HRMS calc for [C36H-CI- O5S + H] 733.1092 found 733.1096. Example 28:4-{2-[1-benzhydryi-5-chloro-2-(2-a(3f4- dichloropnenyl)sulfdnyl]amlno}ethyl)-1 H-indol-3-yrjethoxy)benzoic add Step 1: To the methyl 4-p-{2-(2-amrnoethy1)-1-benzhydry1-5-chJoro-1HHndol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added 3,4-dichlorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 60% yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 80% yield. HRMS calc for [C38H31CI3N2 O5S + H] 733.1092 found 733.1094. Example 29 4-{2-1-benzhydryl-5-chloro-2-(2-a(2f3- dichtorobenzyl)sulfdnyl]amino}ethyl)-1H indol*3-yl]ethoxy}benzofc acid Step 1: To the methyl 4-2-2-aminoethyl)-1-ben2hydry1-5-chloro-1H-Jndol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added (2,3-dichlorophenyl)- methyl]sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 50% yield. Step2-The resulting ester was hydrolyzed by stirring with KOH (67 mg, 5 equiv.) in THF (5 mL) MeOH (5 mL) and H2O (2 mL). The reaction was monitored by TLC (10% MeOH-Ct-feClj) for the disappearance of starting material. The mixture was stirred overnight at room temperature and then concentrated, diluted with H2O, and acidified to pH 2-4 using 1 M HCI. The aqueous phase was extracted with EtOAc and the organic phase was washed with brine, dried over sodium suffate, and concentrated to afford the desired product in 98% yield. HRMS calc for [C39H33Cl3N2 O6S + H] 747.1249 found 747.1254. Example 30:4-2-[1-benzhydryl-5-chloro-2-(2-{I(2,4- dichlorobenzyl)sulfonyfJaniino}ethyl)-1H- lndol-3-yf]ethoxy}benzoic acid Step 1: To the methyl 4-{2-[2-{2-aminoethyl)-1-benzhydryl-5-chloro-1HHndol- 3-yl]ethoxy)benzoate (Step6, Example 1) was added (2,4-dichlorophenyl)- methyl]sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 98% yield. Step2- The ester intermediate was hydrolyzed according to Step 2 Example 29 to afford the title acid in 90% yield. HRMS calc for [C39H33CI3N2O5S + H] 747.1249 found 747.1255. Example 31:4-{2-[1-benzhydryl-5-chloro-2-2-{[(2f4- dichlorobenzyl)siilfonyl]amino}ethyl)-1H indol-3-vf]ethoxy}benzoic acid Step 1: To the methyl 4-(2-{2-(2-aminoethyl)-1-benzhydryl-5-cNoro-1HHndol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added (2-chlorophenyl)-methyl]sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 86% yield. Step2- The ester intermediate was hydrolyzed according to Step 2 Example 29 to afford the title acid in 90% yield. HRMS calc for [C39H34CI2-O5S + H] 713.1638 found 713.1644. Example 32:4-{2-{1-benzhydryl-5-chloro-2- (2-{£(4-chloro-2- nitrobenzyl)surfonyl]amino}etriy1)-1 H-indol-3-yl]ethoxy}benzoic acid Step 1: To the methyl 4-{2-{2-{2-aminoethyl)-1-benzhydryl-5-chloro-1H-Jndol- 3-yt]ethoxy}benzoate (Step6, Example 1)was added [(4-chloro-2-nrtro)-methyl] sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 74% yield. Step2- The ester intermediate was hydroryzed according to Step 2 Example 29 to afford the title acid in 90% yield. HRMS calc for [C39H33Cl2N3O7S + H] 758.1489 found 758.1494. Method I The acid resulting from Method A, or any subsequent method could be used as a subtrate for palladium catalyzed amination reaction using a base, an amine, a phosphine ligand and palladium reagent Example 33: 4-[2-(1-beruhydryl-2-{2-{(benzylsulfonyl)amino}othyl}-5- morpholin-4-yM H-indol-'3-yl)ethoxy]benzoic acid Step 1- A flask was charged with tris(dibenzylideneacetone) dipalladium(O) (.01 eq.), 2-(dM-butylphosphino)biphenyl (0.04 eq.), sodium f-butoxide (2.4 eq.) and the acid from step 8 (1.0 eq.). 1.5 ml toluene (1.0 M) was added to the flask followed by morpholine (1.2 eq.) The reaction was heated to reflux for five hours. The reaction mixture was partitioned between 5% hydrochloric acid and dietheyl ether. The organic layer was washed with distilled water, followed by brine, dried over sodium suffate and concentrated. The product was purified by preparatory LC-MS to afford 7.8% of the desired product HRMS calc for [C43H43N3O6S + H] 730.2945 found 730.2945. Example 34:4-{2-{1-Benzhydryl-5-chloro-2-(2-{[(2-cyanobenzyl)- sutfonyl]amlno}ethyl)-1H-indol-3-yl}ethoxy}benzoic acid Step 1: (2-Cyano-phenyl)-methanesulfdnyl chloride was prepared according to Example 18 Step 1-2 (crude yield 100%). Step 2: The title compound was prepared from 4-{2-{2-(2-amino-ethyl)-1- benzhydryl-5-chloro-1H-ndol-3-yl]-ethoxy]-benzoic acid methyl ester (Step 6, Example 1) and (2-cyano-phenyl)-methanesuJfonyl chloride according to Example 1 Step 7 as a white solid in 72% yield. Step3- The ester intermedate was hydrdyzed according to Step 8 Example to afford the title add in 74% yield. MS (ES) nVz (M-1) 702.0; HRMS Calcd. for C40H35CIN3O5S (M+1): 704.1980. Found: 704.1984. Anal. Calcd. for C40H34CIN3O5S: C, 68.22; H. 4.87; N, 5.97. Found: C, 67.92; H, 5.11; N, 5.54. Example 35: 4-{2-{1-benzhydryl-6-chloro-2-(2-{[((3,5-dmuorobenzyl)- su!f6nyl]amino}ethy1)-1H* indol-3-yl]ethoxy}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 3,5- difluorobenzyl bromide according to the procedure in Example 18 Step 1-2 in 95% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-{2-{2-(2-aminoemylM-nzhydryl-5-(ttofcM Example 1) according to the procedure in Example 1 Step 7 in 78% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title diadd in 83% yield. HRMS calc for [C39H39CIF2N2 O5S + H] 715.184 found 715.1842. Example 36: 4-{2-{1-Benzhydiyl-5-chloro-2-{2-{[(3-cyanobenzyl)- surfonyl]amino}ethyl)-1H-indol-3-yl]ethoxy}benzoic acid Step 1: (3-Cyano-phenyl)-methanesulfonyl chloride was prepared according to Example 18 Step 1-2 (crude yield 100%). Step 2: The title compound was prepared from 4-{2-{2-(2-amino-ethyl)-1- benzhydryJ-5-loit)-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester (Step 6, Example 1) and (3-cyano-phenyl)- methanesulfonyl chloride according to Example 1 Step 7. Step3- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 81% yield. MS (ES) mfe (M-1) 702.1; HRMS Calcd. for C4oH33CIN306S (M-1):702.1834. Found: 702.1833. Anal. Calcd. for C40H34CIN3O5S0.8H2O: C,67.00; H, 5.00; N, 5.86. Found:C,67.22; H, 5.19; N, 5.44. Example 37:4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(4-cyanobenzyl- )eulfonyl]amino)ethyl)-1H-lndol-3-y1]ethoxy)benzoic acid Step 1(4-Cyano-phenyl)-methanesulfonyl chloride was prepared according to Example 18 Step 1-2 (crude yield 100%). Step 2: The title compound was prepared from 4-{2-{2-(2-amino-ethyl)-1- benzhydryl-5-loro-1HHndol-3-yl]-etnoxyH)erizoic acid methyl ester (Step 6, Example 1)and (4-cyano-phenyl)- methanesulfonyl chloride according to Example 1 Step 7. Step3- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 77% yield.MS (ES) m/z (M-1) 702.1; HRMS Calcd. for C40H35CIN3O5S (M+1): 704.1980. Found: 704.1981. Anal. Calcd. for C40H34CIN3O5S: C, 68.22; H, 4.87; N, 5.97. Found: C, 68.09; H, 4.97; N, 5.73. Example 38:4-(2-(1-Benzhydryl-5-chloro-2-{2-({I4-1plperidinyl- sulfonyl)benzyl]sulfonyl} amino)ethyl]-1H-indol-3-yl}ethoxy)benzoic acid Step 1:[4-(Piperidine-1-sulfonyl)-phenyl]-methane8ulfonyl chloride was prepared according to Example 18 Step 1-2 (crude yield 100%). Step 2: The title compound was prepared from 4-{2-[2-(2-amino-ethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl]-ethoxy)-benzoic add methyl ester (Step 6, Example 1) and 4-(Piperidine-1-sulfonyl)-phenyl]-methanesulfonyl according to Example 1 Step 7. Step3- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 73% yield. MS (ES) mte (M-1) 824.2; HRMS Calcd. for C44H43CIN3O7S2 (M-1):824.2236. Found: 824.2246. Anal. Calcd. for C44H44CIN-S2 0.5H2O: C, 63.25; H, 5.43; N, 5.03. Found: C, 62.85; H, 5.64; N, 4.64. Example 39:4-(2-{2-[2-({[4((Aminoeulfonyl)benzyl]sulfonyl]- amino)ethyl]-1-benzhydryl-5-chloro-1 H-indol-3-yl}ethoxy)benzolc acid Step 1: (4-Sulfamoyl-phenyl]-methanesuifonyi chloride was prepared according to Example 18 Step 1-2 (crude yield 100%). Step 2: The title compound was prepared from 4-{2-[2-(2-amino-ethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl]-ethoxy)-benzoic acid methyl ester (Step 6, Example 1) and (4-Surfamoyl-phenyl)-methanesulfonyl chloride according to Example 1 Step 7. Step3- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 69% yield. MS (ES) m/z (M-1) 755.9; HRMS Calcd. for C,BHMCIN,O7S2 (M-1): 756.1613. Found: 756.1612. Anal. Calcd. for C39H39CIN3O7S- C, 61.77; H, 4.79; N, 5.54. Found: C, 61.93; H, 5.12; N, 5.19. Example 40: 4-(2-{1-Benzhydryl-5-chloro-2-I2-(4-rnethanesulfonyI- phenylmethanesulfdnylamino) -ethyl])1H-indol-3-yl}-ethoxy)-benzoic acid Step 1: ((4-Methanesutfonyl-phenyl)-methanesutfonyl chloride was prepared according to Example 18 Step 1-2 (crude yield 100%). Step 2: The title compound was prepared from 4-{2-[2-(2-amino-ethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester (Step 6, Exaniple 1) ((4-Methanesulfonyl-phenyl)-methanesuffonyl chloride according to Example 1 Step 7. Step3- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 75% yield. MS (ES) m/z (M-1) 755.0; HRMS Calcd. for C470H38CIN2O7S2 (M+1): 757.1804. Found: 757.1804. Anal. Calcd. for C40H37CIN2O7S2.H2O: C, 61.96; H, 5.07; N. 3.61. Found: C, 61.82; H, 5.10; N, 3.48. Example 41: 4-(2-{1-Benzhydryl-5-chloro-2-{2-(4-diethylsurfamoyl- phenylmethanesulfcnytamino) -ethyl]-1H-indol-3-y1}-ethoxy)-benzoic acid Step 1: (4-Diethylsurfamoyl-phenyl)menethane8ulfonyl chloride was prepared according to Example 18 Step 1-2 (crude yield 100%). Step 2: The title compound was prepared from 4-{2-I2-{2-amir»o-ethyl)-1- benzhydry1-5-k)n)1H-indol-yl]-ethoxy}-benzoic add methyl ester (Step 6, Example 1) and (4-Diethylsurfamoyl-phenyt)-methanesurfony1 chloride according to Example 1 Step 7. Step3- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 66% yield. MS (ES) m/z (M-1) 812.1; HRMS Calcd. for C43H45CIN3O7S2 (M+1): 814.2382. Found: 814.2385. Anal. Calcd. for C43K44CIN3O7S2.O.3H2O: C, 62.99; H. 5.48; N, 5.14. Found: C. 62.91; H, 5.67; N, 4.79. Example 42:4-{341-Benzhydryl--chloro-2-(2-phenylniethane- surfony1amirK)-thytHH-ndol-3-yl]-propy1}-berizolc acid Step 1: A mixture of methyM-iodobenzoate (5.3g, 20.2 mmol), allyt alcohol (1.78g, 30.3 mmol), NaHCOj (4.24g, 50.5mmol), Pd(OAc)2 (0.14g, O.GOmmol), (n- Bu)4NBr (6.55g, 20.2 mmol) and 4-A molecular Sieves (4.1g) in anhydrous DMF (69mL) was stirred at room temperature for 4 days. The reaction mixture was filtered through celite and the filtrate poured onto water and extracted with EtOAc. Organic layer was washed with brine, dried (Na2O-, and concentrated under vaccum. Rash chromatography (silica gel, 10-20 % EtOAc-hexanes) gave 2.11g (85% based on the recovered starting material) of the desired 4-(3-Oxo-propyl)-benzDic acid methyl ester as a clear oil. Step 2: To a solution of 5-chJoro-2-methylindole (0.86g, 5.2mmol) and 4-(3- Oxo-propyl)-benzoic acid methyl ester (1.0g, 5.2mmol) in methylene chloride (50mL), was added TFA (1.78g, 15.6mmol), followed by triethylsilane (1.81g, 15.6mmoJ). The reaction mixture was stirred overnight quenched with sat. NaHCO3 solution (50mL), and the organic layer was washed with sat NaHCOs solution, water, brine, and dried (Na2SO4). Solvent was removed under reduced pressure, and the residue was purified by flash column chromatography with 10-20% EtOAc/hexanes to yield the desired product in 94% (1.67g) yield. Stop 3: To a solution of the product from step 2 (1.66g, 4.86mmol) in DMF (20mL) was added NaH (60% in mineral oil, 0.24g, 5.83mmol) under N2 atmosphere. The mixture was stirred for 1h at room temperature, followed by the dropwise addition of benzhydryl bromide (1.8g, 7.29mmoO in DMF (5mL). This reaction mixture was stirred overnight at room temperature. Water (500mL) was added to reaction mixture, it was extracted with EtOAc, washed with brine, dried (Na2SO4), and concentrated under reduced pressure to a brown syrup, which was purified by silica- gel chromatography using 10% EtOAc/hexanes as eluent to isolate 4 as a white solid in59%(1.47g)yield. Step 4: The product from above (1.46g, 2.87mmol) was dissolved in CCU (14.5mL), followed by the addition of NBS (1.02g, 5.73mmol) and benzoy) peroxide (2mg). The reaction mixture was heated to reflux for 1 h (until all the starting material disappeared). This mixture was cooled to room temperature, filtered and the solid was washed with CO*. The filtrate was evaporated to a brown residue, which was dissolved in acetone (40mL) and water (4mL), Ag-Oa (1.75g, 3.16mmo!) was then added to this solution and after being stirred overnight at room temperature, it was filtered through celite, the solvent was evaporated under reduced pressure, and water was added to the residue. It was extracted with EtOAc, washed with brine, dried (Na2SO4), and evaporated to a syrup, which was purified by 10% EtOAc/hexanes to isolate the 2-formyl indote (1.13g) in 75% yield. Alternatively the dibirmide from the reaction with NBS could be poured into DMSO (10-20% concentration by weight) and stirred for 30 minutes at room temperature. When the reaction was deemed complete it was poured into water and the resulting precipitate was isolated by filtration, the cake was washed with water and dried to yield an essentially quantitative yield. Step 5: To a solution of the 2 formyl indote from above (0.52g, 1mmol) in CH3NO2 (6.2ml_) was added NR.OAC (0.077g, 1mmoQ, the mixture was heated to reflux for 1h, NI-UOAc (0.077g, 1mmoO was then added, heating at reflux was continued for an additional 1h, NH,Oac (0.077g, 1mmol) was added again and the heating continued for further 1h. The reaction mixture was allowed to attain room temperature, EtOAc (50mL) was added, followed by the addition of 10OmL water. The aqueous layer was extracted with EtOAc, and the combined organic layers were washed with brine, dried (Na2SO4), and evaporated to a yellow foam, which was subjected to chromatographic purification using 10% EtOAc/hexanes as an eluent to yield 6 as a yellow foam in 68% yield (0.38g). Step 6: Zn(Hg) was made by adding HgCl2 (3.4g, 7.2 mmoO to a mixture of Zn-dust (34.68g, 530.35mmol) and 5% Hcl (38mL) in a 100mL beaker, this mixture was stirred vigorously for 10 min. Aqueous pHClse was decanted and added 38mL of 5% HO again and the mixture was stirred for 10 min. Aqueous pHClse was decanted. This solid was added to the vinyl nitro compound 6 (15g, 26.57mmol) in THF (660mL) and cone. HCl (64.5mL). This mixture was stirred at room temperature for 1h, then at reflux for 15 min. The reaction mixture was cooled to room temperature and filtered through cefite. Aq. NK.OH solution (200mL) was added to the filtrate, stirred for 15 min and THF was removed under reduced pressure. The aqueous layer was extracted with CH2Cl2, combined organic layer was washed with brine, dried (Na2SO4) and concentrated to a brown foam, which was purified by column chromatography by eluting the column with CHCIs in the beginning to remove non- polar impurities then with 2% MeOH/CHCI3 to isolate the desired amine in 46% yield (6.1g) Step 7: To the amine(1.0 equiv.) and sat. NaHCO3 (0.14 M) in CHClO2 (0.07 M) was added a-toluenesulfonyf chloride (1.0 equiv.). After 1 h the mixture was poured into saturated sodium bicarbonate and extracted with CH2CI2. The combined organic pHClse was washed with brine, dried over sodium suffate and purified by column chromatography to afford 84% of the desired product Step 8: The resulting ester was hydrolyzed by stirring with 1N NaOH (5 equiv.) in THF (0.07 M) and enough MeOH to produce a clear solution. The reaction was monitored by TLC (10% MeOH-CH2Cl2 for the disappearance of starting material. The mixture was stirred overnight at room temperature and then, concentrated, diluted with HCl and acidified to pH 2-4 using 1 M HCI. The aqueous pHClse was extracted with EtOAc and the organic pHClse was washed with brine, dried over sodium sulfate, and concentrated to afford the desired product in 100 % yield. HRMS calc for [C40H37CIN2C4S + H] 677.2235 found 677.224. Example 43:4-{3-{1-benzhydry1-5-chloro-2-(2-{I(3,5- (flchlorobenzyl)sulfonyl]aniino}ethyl)-1H- indol-3-yfJpropyl}benzolc acid Step 1: This compound was prepared from the intermediate in Example 42 step 6 and (3,5-dichlorophenyl)-methyl]sulfonyl chloride according to the procedure in Example 43 Step 7 which yielded 98% of the desired product Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title acid in 100% yield. HRMS calc for [C40C35Cl3N2CO4S + H] 745.1456 found 745.1458. Example 44:4-{3-[1-benzhydry1-5-chloro-2-(2-a(3,4- dichlorobenzyi)sulfonyl]amino}ethyl)-1H- lndol-3-yl]propyl}benzolc acid Step 1: This compound was prepared from the intermediate in Example 42 step 6 and (3,4-ichlorophenyl)-methyrjsulfonyl chloride according to the procedure in Example 43 Step 7 which yielded 96% of the desired product Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title add in 98% yield. HRMS calc for [C40HCl35Cl3N2S + H] 745.1456 found 745.1458. Example 45:4-p-{1-benzhydryl-5-chloro-2-(2- [(methyteulfonyl)amino]ethyl)-1 H-indol-3-yl]ethoxy}benzoIc acid Step 1: To the methyl 4-[2-[2-(2-aminoethyi)-1-benzhydry1-5-chloro-1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1)was added metHClnesutfonyl chloride according to the procedure in Example 4 Step 1 to generate the product in 92% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 100% yield. HRMS calc for [C33H31CIN2O5S + H] 603.1715 found 603.1717. Example 46:4-p-(1-be(izhydryl-5-chtor©-2-C2- [(phenytsulfony1)amino]ethyl}-1 H-indoJ-3-yl]ethoxy}benzoic acid Step 1: To the methyl 4-{2-[2-{2-aminoethyf)-1-benzhydryJ-5-chloro-1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1)was added benzenesurfonyl chloride according to the procedure in Example 4 Step 1 to generate the product in 90% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C35HClCIN2O5S + H] 665.1872 found 665.1869 Example 47:4-(2-{1-benzhydry1-6-chloro-2-p-({r) (trffluoromethyl)benzyl]sulf6nyl)amlno)- acid Step 1: To the methyl 4-{2-{2-{2-aminoethy1)-1-t)enzhydryl-5-chk)ro-1HHndol- 3-yl]ethoxy}benzoate (Step6, Example 1)was added {[3- (trifluoromethyl)phenyllmethyl}sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 74% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 86% yield. HRMS calc for [C4oH34CIF3N2OsS + H] 747.1902 found 747.1904 Example 48:2-fl(2-a(2-{1-benzhydryl-3-[2-(4-carboxypherK)xy)ethyl]-5. chloro-1 H-indol-2-yl}ethyl)amino]8ulf6nyl}ethyl)amino]carbonyl}benzoic acid Step 1: To the methyl 4-{2H2-(2-aminoethy1)-1-benzhyclfyl-5-chloro-1H-indol- 3-y(]ethoxy}benzoate (Step6, Example 1)was added 2-phtHCllimidoetHClnesuffonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 78% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 99% yield. HRMS calc for [C42H35CIN3O8S + H] 780.2141 found 780.2148 Example 49:4-{2-{{1-benzriydryl-5-chlorc)-2-(2-{I(3- (pyridinylmemyi)sulfbnyl]amino}ethylHH-indol-yl]elhoxy}bonzoicacid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol- 3-yt]ethoxy}benzoate (Step6, Example 1)was added (3-pyricfyknethyt)sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 52% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 94% yield. HRMS calc for [C36H34CIN3O5S - H] 678.18349 found 678.18277. Example 50:4-{2-{{1-benzhydfyl-chloro-2-(2-{[(4- (pyridinylmethyl)sulfonyl]amino}ethyl)-H-indol*3-qethoxy}benzolcacid Step 1: To the methyl 4-(2-{2-{2-aminoethyl)-1-benzhydryl-5-chloro-1 H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1)was added (4-pyridylmethyl)sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 57% yield. Step 2: The ester intermediate was hydrolyzed according to Step 6 Example 1 to afford the title acid in 100% yield. nVz (M-1) HRMS calc for [C35H34CIN3O5S -H] 678.18349 found 678.18249 Example 51:4-{2-[{1-benzhydryl-5-chloro-2-(2-{I(2- (pyridinylmethyl)suH6nyl]amino}ethyl)-1 H-indol-3-yl]ethoxy}benzoic acid Step 1: To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1)was added (2-pyridylmethyf)sulfbnyl chloride according to the procedure in Example 1 Step 7 to generate the product in 42% yield. Step 2: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title add in 56% yield. HRMS calc for [C38H34CIN3O5S -H] 678.18349 found 678.18312 Example 52:4-H1-benzhydiyk5-hloro-2-{2-{[(2,6-limethylbenzyl)- sulfonyl]amino}ethyl)-1H-lndoly-3-yl]propy1}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 2,6- dimethylbenzyl chloride according to the procedure in Example 18 Step 1-2 in 100% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and the intermediate in Example 42 step 6 according to the procedure in Example 42 Step 7 in 30% yield. Step 3: The ester intermediate was hydroryzed according to Step 8 Example 42 to afford the title acid in 100% yield. HRMS calc for [C-miCIN-S -H] 703.24028 found 703.23973 Example 53:4-241-bwzhydryi-5-hl()ro-2-(2-a(cyclohexylrriothyl)- suH6nyl]amino}ethyl)-1H-inclok3-yl]ethoxy}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from (bromomethyl]cyclohexane according to the procedure in Example 18 Step 1-2 in 100% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-{2-[2-(2-aminoemyl)-1-benzhydryl-chloro-1h-3-yl]benzoate (Step6, Example 1) according to the procedure in Example 1 Step 7 in 20% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 73% yield. HRMS calc for [C39h41CIN2O5S -H] 683.23519 found 683.23474 Example 54:4-{2-[1-benzhydryl-5-chloro-2-(2-(((4- nitrobenzyf )sutfonyr]amino}ethyl)-1 H-indol-3-yl]ethoxy}benzoic acid Step 1: The sulfonyf chloride intermediate was prepared from 4-nrtrobenzyl bromide according to the procedure in Example 18 Step 1-2 in 95% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-{2-[2-(2-aminoemyl)-n2*iydryl-5-chloro-1h-indol-3-yl]ethoxy}benzoate(step6 Example 1) according to the procedure in Example 1 Step 7 in 80% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title compound in 90% yield. HRMS calc for [C39H34CIN3O7S+H] 724.1879 found 724.1884. Example 55:4-(2-C1-benzhydiyl-5-chloro-2-(2-{[(3- nKrobenzyl)sulfdnyl]amlno}ethylHH-ndol-3-yl]ethoxy}benzoie acid Step 1: The sulfonyl chloride intermediate was prepared from 3-nitrobenzyl bromide according to the procedure in Example 18 Step 1-2 in 95% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-{2-2-aminoethylM-beiizhydryl-5-chl- (Step6, Example 1) according to the procedure in Example 1 Step 7 in 85% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title compound in 85% yield. HRMS calc for [C39H34CIN3O7S + H] 724.1879 found 724.1885. Example 56:4-{2-I1-Bwizhydryl-5(hloro-2-{2-{({2-nltrob©nzyf}- »ulfonyl)amino]ethyf}-1H-indol-3-yt) propyl]benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chIoro-1H-indol- 3-yl]propyl}benzoate (Step 6, Example 42) was added and 2-nitro-a-toluenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C40H35CIN3O6S + H] 722.2086 found 722.2088. Example 57:4-{3-[1-benzhydry1-5-chloro-2-{2-{I(4- fluorobenzyl)sulfonyfJamino)ethy1)-1H- indol-3-yl]propyl}benzoic add Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol- 3-yl]propyf)benzoate (Step 6, Example 42) was added and (4-Fluoro-phenyl)- metHClnesulfbnyl chlorideaccording to the procedure in Example 1 Step 7 to generate the product in 77% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 68% yield. HRMS calc for [C40H36CIFN2S + H] 695.2141 found 695.2145. Example 58 4-3-{1-benzhydryl(5-chlon)-2-[2-({[4- (trifluoromethyl)benzyf]sulfonyl}amino)ethyl]-1 H-indol-3-yl}propy!)benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyll)-1-benzhydryl-5-chloro-1H-indol- 3-yl]propyl]benzoate (Step 6, Example 42) was added and (4-Trifluoromethyl- phenyl)-metHClnesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 50% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C41H36CIF3N2O4S + H] 745.2109 found 745.2114. Example 69:4-(3-{1-benzhydryl-5-chloro-242-{[3- (trifluoromethyt)benzyl]sulfonyr)amino)ethyn]-1 H-lndol-3-y1}propyl)benzolc acid Step 1: To methyl 4-{2-{2-{2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was added and (3-Trifluoromethyl-phenyl)- metoanesuifonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 56% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 82% yield. HRMS calc for [C41H36CIF3N2O2S + H] 745.2109 found 745.211. Example 60:4-3-[1-benzhydryl-5-chloro-2-(2-{I(4- chlorobenzyi)sulfbnyl]amino}ethy1)-1H- indol(4-yl]propyf}benzoic acid Step 1: To the methyl methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro- 1Hnndol-3-yl]propyl]benzoate (Step 6, Example 42) was added and (4-chtorophenyl)- metHClnesuffonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 74% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 79% yield. HRMS calc for [C--CkN-S + H] 711.1846 found 711.1847. Example 61:4-{H1-benzhydiyl-5-chloro-2-(2-a(2- pyridinylmethy1)sulfonyl]amlno}ethyf)-1H- indo4-3-yl]propy1}benzoic add Step 1: To the methyl 4-2[2-2-eminoethyl)-1-benzhydfyl-5-chloro-1H-indol- 3-yl]propyl}benzoate (Step 6, Example 42) was added pyridin-2-yl-metHClnesulfonyl chloride chloride according to the procedure in Example 4 Step 1 to generate the product in 75% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 96% yield. HRMS calc for [C39HCl35CIN3C4S + H] 678.2188 found 678.2187. Example 62:4-{[1-benzhydryl-6-chloro-2-(2-{[(3- pyridinylmethyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyl}benzoic acid Step 1: To the methyl 4-2-2-2-amirK)eth-14)enzhydryl-5-chloro-1H-indol- 3-yl]propyl]benzoate (Step 6, Example 42) was added pyridin-3-yl-metHClnesutfonyl choride chloride according to the procedure in Example 4 Step 1 to generate the product in 75% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 88% yield. Example 63:4-[3-{1-*)enzhydryl-5-chloro-2-(2-{[(4- pyridinylmethyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyf}benzoic acid Step 1: To the methyl 4-[2-I2-(2-aminoethyl)-1-benzhydryl-5-chloro-1HHndol- 3-yl]propyl}benzoate (Step 6, Example 42) was added pyridin-4-yl-metHClnesulfonyl chloride chloride according to the procedure in Example 4 Step 1 to generate the product in 75% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 77% yield. HRMS calc for [C39H36CIN3C-S -H] 676.20423 found 676.20405 Example 64:4-H1*benzhydryl-5-chloro-2-(2-{[(2- chlorobenzyl)sulfonyl]amino}ethyf)-1H- lndol-3-yl]propyl}benzoic add Step 1: The sulfbnyl chloride intermediate was prepared from 3-chlorobenzyl bromide according to the procedure in Example 18 Stop 1-2. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-242K2-aminoethy1)-14)enzhydry-5-chlon2- (Step 6, Example 42) according to the procedure in Example 1 Step 7 in 10% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title compound in 100% yield. HRMS calc for [C40H36Cl2N204S -H] 709.17000 found 709.16961 Example 65:4-{3-[1-b(mzhydryl-5-chloro-2-(2-tt(3- nftrobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yf]propyf)benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 3-nitrobenzyl bromide according to the procedure in Example 18 Step 1-2. Step 2: The methyl ester was prepared from the sulfonyi chloride and methyl 4-2-2-aminoethyl)-1-enzhydryl-5-k- (Step 6, Example 42) according to the procedure in Example 1 Step 7 in 43% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title compound in 88% yield. HRMS calc for [C-HmCIN-S -H] 720.19405 found 720.19398 Example 66:4-{3-{1-benzhydryl-5-chloro-2-{2-{K3-chloroben2yl) sulfonyl]amino}ethy1)-1H- indoJ-3-yf]propy1}benzoic acid Step 1: The sulfonyi chloride intermediate was prepared from 3-chlorobenzyt bromide according to the procedure in Example 18 Step 1-2. Step 2: The methyl ester was prepared from the sulfonyi chloride and methyl 4-2-2-2-mirK)ethyl)-14)enzhydiyk5-chk)ro-1H- (Step 6, Example 42) according to the procedure in Example 1 Step 7 in 27% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title compound in 93% yield. HRMS calc for [O40H36Cl2N2O4S -H] 709.17000 found 709.16963 Example 67:4-f){1-benzhydryl-5-chloro-2-(2-{I(2,6-dichloroben2yl) •ulfonyl]amino}ethy1)-1H- lndol-3-yl]propyt}benzoic acid Step 1: The sulfonyi chloride intermediate was prepared from 2,5- dichlorobenzyl bromide according to the procedure in Example 18 Step 1-2. Step 2: The methyl ester was prepared from the sulfonyi chloride and methyl 4-2-2K2-minoethyl-1-benzhydryi-5-chloro-1H-indol-3-yl]propy0benzoate (Step 6. Example 42) according to the procedure in Example 1 Step 7 in 59% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title compound in 100% yield. HRMS calc for [C4oH35,N2O4S -H] 743.13103 found 743.13079 Example 68:4-{3-[1-benzhydryl-5-chloro-2-{2-tt(3- methoxybenzyl)sulfonyl] amino}ethy1)-1H- indol-3-yl]propyl}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 3- methoxybenzyl bromide according to the procedure in Example 18 Step 1-2. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-2-2-2-min(-thy1)-1-benzhydryl-5--lor()iH-ndol-3-ynpropyI}benzoate (Step 6, Example 42) according to the procedure in Example 1 Step 7 in 20% yield. Step 3: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title compound in 100% yield. HRMS calc for [C41H39CIN2OSS -H] 705.21954 found 705.21909 Example 69:4-{3-I2-(2-a(2-amlnobenzy1)8urfony1]amIno}ethyl)-1- benzhydryl-5-hloro-1H-indol-3-y1]propyr}benzoic acid Step 1: The intermediate from Step 1 Example 56 was treated with SnCfe according to the procedure in Step 1 Example 16 to yield the amino ester in 99% yield. Step 2: The ester intermediate was hydrotyzed according to Step 8 Example 1 to afford the title add in 100% yield. HRMS calc for [C40H39CIN3-S -H] 690.21988 found 690.21941 Example 70:4-{H1-Beizhydryl-6-chloro-2-(2-a(2-methylbenryI)8ulfonyrj amino}ethyl)-1H-fndol-3-y1]propy1}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 2-Methylbenzyl bromide according to the procedure in Example 18 Step 1-2 in quantitative yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and the intermediate in Example 42 step 6 according to the procedure in Example 42 Step 7 in 50% yield. Step 2: The ester intermediate was hydroryzed according to Step 8 Example 42 to afford the title acid in 93% yield. HRMS calc for [C41H39CIN2O4S -H] 689.22463 found 689.22421 Example 71:4-{2-[1-Benzhydryl-&ehloro-2-(2-{[(4-trifluoromethoxy benzyl) sulfonyl]amino}ethyt)-1H-lndol-3-yl]ethoxy)benzoic acid Step 1: The sutfonyl chloride intermediate was prepared from 4- Trifluorornetoxybenzyl bromide according to the procedure in Example 18 Step 1-2 in quantitative yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-2-2-2-aminoethyl)-1-ben2hydryf-5-chloro-1H-indol-S-yllethoxy}ben2oate (Step 6, Example 1) according to the procedure in Example 1 Step 7 in 48% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 85% yield. HRMS calc for [C40CIF3N2O6S -H] 761.17054 found 761.17031 Example 72:4-{2-[1-Benzhydryl-6-chloR)-2-(2-a[(2-fluon)-- nitrobenzyl)sulofony!] amino}ethyl)-1H-indol-3-yf]ethoxy}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 2-Fluoro, 6- nitrobenzyl bromide according to the procedure in Example 18 Step 1-2 in quantitative yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-2-2-amiroethytH-benzhydryl-5-chlon2-1H-indol-3-yl]ethyl]benzote(Step6, Example 1) according to the procedure in Example 1 Step 7 in 91% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield, m/z (M-1) 740.05 Example 73:4-{2-1-Benzhydryl-6-chloro-2-(2-{[(2- dichlorobenzyl)surfonyl] amino)emyl)-1H-indok3-yl]ethoxy}benzolc acid Step 1: The c chloride intermediate was prepared from 3,5-dichlorobenzyl bromide according to the procedure in Example 18 Step 1-2 in theoretical yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-242K2-minoethyl-14en2ydryt-5-chloro-1H-indoJ-3-yl]ethoxy}benzoate(Step6, Example 1) according to the procedure in Example 1 Step 7 in 100% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 81% yield, m/z (M-1) 747.2. HRMS calc for [C39H33CI3N2O5S -H] 745.11030 found 745.10954. Example 74:4-{2-[1-Benzhydryl-5-chloro-2-(2.{[(2,6- difluorobenzyl)sulf6nyl]amino} ethyl)-1H-indol-3-yl]ethoxy}benzolc acid Step 1: The sulfonyl chloride intermediate was prepared from 2,6- difluorobenzyl bromide according to the procedure in Example 18 Step 1-2 in 95% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-2K2-aminoethyTh14)enzhydryl-5- (Step6, Example 1) according to the procedure in Example 1 Step 7 in 86% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 71% yield, m/z (M-1)714. HRMS calc for [C39H33CIF2N2O5S -H] 713.16940 found 713.16906 Example 75:4-(2-{1-benzhydryl-5-chloro-2-p-({I(e-hloro-3- pyffidlnyl)methyl] suHbnyl}amino)ethyl]-1H-indol-3-l)etlioxy)benzolc acid Step 1: (6(hloro-3-pyridinyl)-metHClnol (1.0 eq.) was taken up in dichlorometHClne and stirred overnight with carbon tetrabromide (1.5 eq.) and 1,3- bis(diphenyiphosphino)propane (0.75 eq.) Ether was added to the solution and filtration followed by concentration of the filtrate afforded (6-chloro-3-bromomethyl) pyridine in 62% yield. Step 2: The sulfonyl chloride intermediate was prepared from the product of Step 1 according to the procedure in Example 18 steps 1-2. Step 3: The methyl ester was prepared from the sulfonyl chloride and methy 4-2-(2-inoethylH-berrtydryl-5-(chloro- (Step6, Example 1) according to the procedure in Example 1 Step 7 in 78 % yield Step 4: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 89% yield. HRMS calc for [CwHClCfeNsOsS -H] 712.14452 found 712.14420. Example 76:4-(2-{1-benzhydryi-5-chloro-2-[2-(n(5,6-dichloro.2. [pyridinyl)methyfj sulfonyf}amino)ethyI]-1H-indol-3-yf)ethoxy)benzoic acid Step 1:5,6-dichloro-3-pyridinemetHClr»ol (1.0 eq.) was taken up in dichJorometHClne and stirred overnight with carbon tetrabromide (1.5 eq.) and 1,3- bis(diphenytphospruno)propane (0.75 eq.) Ether was added to the solution and filtration followed by concentration of the filtrate afforded the 5,6-dichloro-3- bromomethylpyridine in 130% yield. Step 2: The suifonyf chloride intermediate was prepared from the product of Step 1 according to the procedure in Example 18 steps 1-2 in 81% yield Step 3: The methyl ester was prepared from the sulfonyi chloride and methy 4-{2-(2-amiethylo)-1-benzhydryl-chloro--1H-indol-3-yl]ethy}benzoate (Step6, Example 1) according to the procedure in Example 1 Step 7 in 79 % yield Step 4: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 109% yield. HRMS calc for [C36H32CI3N3O5S -H] 746.10554 found 746.10549. Example 77:4-{2-[1-Benzhydryl-5-chk)ro-2-(2-{I(3- methoxybenzy1)sulfonyl] amino}ethyl)-1H-indol-3-yl]etnoxy}benzoic acid Step 1: The sulfonyi chloride intermediate was prepared from 3- methoxybenzyl bromide according to the procedure in Example 18 Step 1-2 in 68% yield. Step 2: The methyl ester was prepared from the sulfonyi chloride and methyl 4-{2-(2-aminoethyl)-1-benzhydry-5-chloro-1H-indol-3-yl]}benzoate( step6, Example 1) according to the procedure in Example 1 Step 7 in 68% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title diacid in 93% yield. HRMS calc for [C39H33Cl3N2O5S +Na] 731.1953 found 731.1947. Example 78:4-{2-[1-Benzhydry1-5-chloro-2-(2-{[(3,5- dimethylbenzyl)suH6nyl] amino}ethyl)-1H-lndol-3-yl]ethoxy}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 3,5- dimethylbenzyl bromide according to the procedure in Example 18 Step 1-2 in 38% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-{2-{2-(2-aminoethy1)-1-benzhydryl-5-chloro-1 H-indc4-3-yl]ethoxy}benzoate (Step6, Example 1) according to the procedure in Example 1 Step 7 in 38% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title diackj in 88% yield, m/z (M-1)705.0 HRMS calc for [C4iH»CIN2O6S - H] 705.21954 found 705.21916. Example 79:4-2-1-Benzhydryl-5-hloro.2-(2-fi(2-rnethylbenzy1)»urfonyl] amlno)ethyl)-1H-indol-3-yl]ethoxy)benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 2-methylbenzyl bromide according to the procedure in Example 18 Step 1-2 in 35% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-2-(2-aminoethy1)-1-benzyl-5-choloro-1H-indol-3yl]ethyl}benzoate(Step6, Example 1) according to the procedure in Example 1 Step 7 in 35% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title diadd in 90% yield, m/z (M-1)691.0. HRMS calc for [C401H37CIN2O6S-H] 691.20389 found 691.20350 Example 80:4-{2-{1-Benzhydryl-5-chloro-2-(2-([(2,6- dichlorobenzyl)sulfonyrj amino}ethyl)-1H-indol-3-yI]ethoxy}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 2,6- dichlorobenzyl bromide according to the procedure in Example 18 Step 1-2 in 3% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4--(2-aminoethylH-benzhydryl-5(M Example 1) according to the procedure in Example 1 Step 7 in 3% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title diacid in 92% yield, m/z (M-1)745.0 The intermediate amine, synthesized using method A, was treated with chJoromethylsulfonyl chloride either under Schott and Baumman conditions or under anhydrous conditions with an organic base yielded a chloromethyl sulfonamide intermediate. This intermediate could be treated with a variety of nudeophiles in DMF with a suitable organic base, Hunigs base, triethylamine etc, and heated until the reaction was complete. The resulting intermediates where then hydrolyzed to yield the final compound. The following examples were synthesized with method C: Examples 81-86 and 118- 121. Example 81:4-(2-{1-benzhydryl-5-chloro-{2({[(phenylsulfanyl)- methyl]sulfonyl} amino)ethyl]-1H-indol-3-yl}ethoxy)benzoic acid The title compound was synthesized as depicted in Method C. Step 1: To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydry|.5-chlon)1H-indol- 3-yl]ethoxy}benzoate (Step6, Example 1) was added chlorometHClnesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product "m 99% yield. Step 2: To methyl 4-{2-{1-ben2hydryl-5-chloro-2- (2a(chloromethyl)sutfonyI]amino}ethyI)-1HHndol-3-yllethoxy}benzoate (0.080M, 1.0 equiv.) and iPr2NEt (3.4 equiv.) in N,N- dirnethylrbrmamide was added thiophenol (2.1- 2.5 equiv.) and the mixture was stirred at 120 oC for 3.5 days. The reaction mixture was diluted with EtOAc and washed with water and brine. The combined organic pHClse was dried over magnesium sulfate and purified by flash chromatography. Step 3:The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 93% yield, m/z (M-1) 709.11. H RMS calc for [C39H35CIN2O5 -H] 709.16031 found 709.15999. Example 82:4-(2-{1-ben2hydryl-5-chloro-2-(2-(2,6-dbtiethyl- phenyteuKanyl metHClnesuJfonytamino)- ethyfj- )-1H-indol-3-yl} -ethoxy)- benzoic acid Step1:To methyl 4-{2-[1-benzhydryl-5-chloro-2-(2- {[(chtoromethyl)sulfonyl]amirK)}ethyrHH- Example 81 stepi, was added 2,6-dimethylthiophenol according to the procedure in Example 81 step 2. The product was purified by the flash chromatography with 25% EtOAc/hexane in 32% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title acid in 80% yield, m/z (M-1)751.0. HRMS calc for [C41H39CIN2O5S2 -H] 737.19161 found 737.19128. Example 83:4-2-{1-benzhydryl-5-chloro-2-[2-(2-methoxy-pheny|. surfanylmetHClnesurfonylamino}-ethyl]]-1 H-indol4-yf}-ethoxy)-benzoic acid Step 1:To methyl 4-{2-[1-benzhydryl-5-chloro-2-(2- {I(chloromethyl)sulfony0amiix)}ethylK1H-ndol-3-yl]ethoxy}benzoate, Example 81 stepi, was added 2-methoxythiophenol according to the procedure in Example 81 step 2. The product was purified by the flash chromatography 30% EtOAc/hexane in 36% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title add in 94% yield, m/z (M-1) 753.3. HRMS calc for C40H37CIN2O6S2 -H] 739.17088 found 739.17052. Example 84:4-2-14)enzhydryl-5-hlcM-2-K2-hloro-6-methyl-phenyl sulfanylmetHClnesulfonylamino)-ethyf]]-1H-indol-3-yl }-ethoxy)-benzofc acid Step 1: To methyl 44241-benzhydry-5-loro-2-2-a(chk)romethyl)sulfonyt] aminoJethylKIH-indol-S-yl]ethoxyJbenzoato, Example 81 stepi, was added 2- chJoro-6-methylthiophenol according to the procedure in Example 81 step 2. The product was purified by the flash chromatography 25% EtOAc/hexane in 46% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title acid in 100% yield, m/z (M-1)771.2. HRMS calc for [C40H37CIN2O6S2 -H] 757.13699 found 757.13730. Example 85:4-(2-{1-benzhydryl-5-chloro-2-I2-(3,5-dichloro- phenylsuHClnyl methanesulfonylamino)- ethyfj- }-1H-indol-3-yl} -ethoxy)- benzoic add Stepi: To methyl 4-{2-[1-benzhydryt-5-chJora-2-{2- {I(chloromethyl)sulfonyl]amino} ethyl)-1H-indol-3-yl]ethoxy}benzoate, Example 81 stepi: was added 3,5-dichlorothiophenol according to the procedure in Example 81 step 2. The product was purified by the flash chromatography 25% EtOAc/hexane in 40% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title acid in 98% yield, m/f (M-1)793.2. HRMS calc for [C40H37CIN2O6S2 -H] 777.08237 found 777.08159. Example 86:4-{2-{1-benzhydry1-5-chloro-2-[2-(3,4-dimethoxy- phenylsuKanyl metHClnesulfonylamf no)-ethyl]-]-1H-indol-3-yl} -ethoxy)- benzolc acid Stepi: To methyl 4-2-1-benzhydryl-5-chloro-2-(2-a(chloromethy1)- sulfonyl]amino}ethyl]-'1H-indol-3-yl]ethoxy}benzoate, Example 81 stepi, was added 3,4-dimethoxythtophenol according to the procedure in Example 81 step 2. The product was purified by the flash chromatography with 35% EtOAc/hexane in 40% yield.. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title acid compound in 99% yield, mfe (M-1)783.3. HRMS calc for [C40H37CIN2O6S2 -H] 769.18144 found 769.18120. The intermediate amine, synthesized using method A, was treated with chloroetHanesulfonyl chloride under anhydrous conditions with an organic base yielded a vinyl sulfonamide intermediate. This intermediate could be treated with a variety of nucteophles in DMF with a suitable organic base, Hunigs base, triethylamine etc, and heated until the reaction was complete. The resulting intermediates were then hydrolyzed to yield the final compound. The following examples were synthesized with Method D: Examples 87*99 and 100- 105.113-117,122-125 and 139. Example 87:4-(2K1-Bcnzhydryl-5-hloro-2-r2-(2-rnorpholin-4-yiethane surfonylamino)-ethyl]-1H-indol-3-yl}-ethoxyH)enzoic acid The title compound was synthesis as depicted in Method D Step 1:To methyl 4-42-2-mirK)ethy1)1-enzhydryJ-5-chloro-1H-indol-3- yl]ethoxy}benzoate (0.16M, 1.0 equiv.), Step6, Example 1, and triethylamine (2.3 equiv.) in THF was added 2-chloroetHanesulfonyl chloride (1.2 eq) dropwise. After 4 h the mixture was poured into brine and extracted with EtOAc. The combined organic pHase was dried over magnesium sutfate and purified by column chromatography to afford 75% of the vinyl sulfonamide. Step2: To the product from step 1 in 1-propanol was added morpholine. After 5h the reaction mixture was evaporated to dryness before redissolving in EtOAc. The organic pHase was washed with brine, dried over magnesium sutfate, and purified by column chromatography to give the desired methyl ester in 89% yield. Step 3: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 89% yield, m/z (M-1) 702.17. HRMS calc for [C38H40CIN3O6S-H] 700.2535 found 700.22500. Example 88:4-(2-{1-Benzhydryl-6-chloro-2-[2-(2-pyrazoM-y|. •tHanesutfonylamino) -ethyl]-1H-indo1-3-yf}-ethoxy)-benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 1H-pyrazole according to the procedure in Example 87 step 2 except tHat it was heated at 80 -C for 18h, in 90 % yield. Step2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 61 % yield. nVz (M-1) 681.24. HRMS calc for [C37H35CIN4O5S-H] 681.19439 found 681.19407. Example 89:4-(2-{1-Benzhydryl-5-chloro-2-[2-(2-phenylamino(etHane 8ulfony1amlno}-ethyl]-1H-indol-3-yl})-ethoxy)-benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and aniline according to the procedure in Example 87 step 2 except tHat it was heated at 80 *C for 8 days, in 50 % yield. Step2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 98 % yield, m/z (M-1) 706.26. HRMS calc for [C40H38CIN3O5S-H] 706.21479 found 706.21452. Example 90:4-2-{1-benzhydryl-5-chk)ro-2-r2-({r2-(1,4-dioxa-8- azaspiro[4.5ldec-yl)ethyl]sulfonyl)amino)ethyl]-1H-lndol-3-l}ethoxy)benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 1,4-dioxa-8-aza-spiro[4.5Jdecane according to the procedure in Example 87 step 2 except that it was stirred overnight, in 82 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100 % yield, m/z (M-1) 756.2. HRMS calc for [C41H44CIN3O7S -H] 756.25157 found 756.25142. Example 91:4-{2-1-benzhydryl-6-chloro-2-(2-{({2-{4-(2-pyridinylH- piperazinyl] ethyl}sulfonyl)amino]ethyl}-1H-indol--yl)ethoxy]benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 1-Pyridin-2-yl-piperazine according to the procedure in Example 87 step 2 except tHat it was stirred overnight, in 86 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100 % yield, m/z (M-1) 776.2. HRMS calc for [C43H44CIN5O5S - HJ 776.26789 found 776.26750. Example 92:4K2-1-benzhydryl-5(hloro-2-I2-({[2-(1H-1)2,4-triazol-1 yl)ethyl] sulfonyl)amlno)efhyl]-1H-indol-3-yl]ethoxy)benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 1H-{1,2,4]triazole according to the procedure in Example 87 step 2 except tHat it was refluxed for 4 days, in 64 % yield Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100 % yield, m/z (M-1) 682.1. HRMS calc for [C38H40CIN3O6S-H] 682.18964 found 682.18964. Example 93:4-(2-{1-benzhydryi-5-chloro-2-(2-{I2-{3,6-(emothyl-1H- pyrazol -yl)ethyr]surfonyl)amlno)ethyl]-1 H-indoJ-3-yf}ethoxy)benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 3,5-dimethyl-1H-pyrazole according to the procedure in Example 87 step 2 except tHat it was refluxed for refluxed 24 hours, in 95 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 62 % yield, m/z (M-1) 709.2. HRMS calc for [C39H39CIN4O5S -H] 709.22569 found 709.22532. Example 94:4-(2-{1-benzhydryl-5-chloro-2-I2-({(2-{3-methyl-1H-pyra2ol- 1-yl)ethyl]sulfony1)amino)ethyl]-1H-indol-3-yI}ethoxy)ben2oic acld Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 3-rnethyL-1H-pyrazole according to the procedure in Example 87 step 2 except tHat it was stirred overnight, in 88 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5. to afford the title acid in 86 % yield, m/z (M-1) 695.2. HRMS calc for [C38H37CIN4O6S -H] 695.21004 found 695.20951. Example 95: 4-2-1-benzhydryl-5-chloro-2-I2-({I2-[4-methyl-1H-pyra2ol- 1-yl)ethyl]surfonyl)amino)ethyl].1H-lndol-3-yl)rthoxy)benzolc acid Step 1: The compound was prepared from the intermediate from Example 87 step land 4-methyL-1H-pyrazole according to the procedure in Example 87 step 2 except tHat IT was refluxed for 2 days, in 81 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5. to afford the title add in 93 % yield, m/z (M-1) 695.2. HRMS calc for [C38H37CIN4O58S -H] 695.21004 found 695.20954 Example 96: 442-1-enzhydryl-6-hloro-2-[({2-[(2R,6S)-2,6-dimethyl- 1-piperidinyf]ethyl}eulfonyl)amlnolethyrh1 H-indOl-3-y1)ethoxy]benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 2,6-dimethyl-piperidine according to the procedure in Example 87 step 2 except tHat it was heated at 70*C overnight in 54 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title add in 79 % yield, m/z (M-1) 726.3. HRMS calc for [C41H46CIN3O6S -H] 726.27739 found 726.27720. Example 97:4-(2-{1-benzhydryl-5-chloro-2-{2-({r2-(2-thioxo-1- imidazolidinyl) ethyl]8urfony1}amino)ethy1]-1HHndol-3-yl}ethoxy)benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and imidazoSdine-2-thione according to the procedure in Example 87 step 2 except tHat it was refluxed for 3 days, in 17% yield.. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 88 % yield, m/z (M-1) 715.3. HRMS calc for [C37H37CIN4O5S -H] 715.18211 found 715.18161. Example 98:4-(2-{1-benzhydryl-5-chloro-2-I2-(a2-(1,3-thiazolidin-3- yl]ethyl] sulfbnyl}amino)ethyl]-1H-lndol-3-yl}ethoxy)benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and thiazoKdine according to the procedure in Example 87 step 2 except tHat it was refluxed overnight, in 33 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title add in 93 % yield, m/z (M-1) 702.3. HRMS calc for [C37H38CIN3O5S2- -H] 702.18686 found 702.18659. Example 99:4-(2-{1-benzhydry1-5-chloro-2-{2-(2- [1,2,3]triazool-yl-etHane surfonytamino)-emy]-1H-i)dol-yf}ethoxy)benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 1H-[1,2,3Jtriazote according to the procedure in Example 87 step 2 except tHat it was refluxed for 5 days, in 23 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 100% yield, m/z (M-1) 682.0. HRMS calc for [C36H34CIN5O5S -H] 682.18964 found 682.18933. Example 100:4-(3-{1-Benzhydryl-S-chloro-2-{2-{2-morpholln-4-yl-etHarne sulfonylamino)-ethyl]- 1H-irtdel-3-yI}-propyl)-benzoic acid Step 1: To methyl 4-{2-{2-(2-aminoethyJ)-1-benzhydryl-5-chloro-1H-indol-3- yl]propyl]benzoate, Step 6, Example 42, (0.16M, 1.0 equiv.) and triethylamine (2.3 equiv.) in THF was added 2-chloroetHanesulfonyl chloride (1.2 eq) dropwise. After 4 h the mixture was poured into brine and extracted with EtOAc. The combined organic pHase was dried over magnesium sutfate and purified by column chromatography to afford the vinyl sulfonamide. Step2: To the product from step 1 in 1-propanol was added morpholine. After 5h the reaction mixture was evaporated to dryness before redissolving in EtOAc. The organic pHase was washed with brine, dried over magnesium sulfate, and purified by column chromatography to give the desired methyl ester in 100% yield. Step 3: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title acid in 85 % yield, m/z (M-1) 698.12. HRMS calc for [C39H42CIN3O5S-CIN3O5S - H] 698.24609 found 698.24581. Example 101:4-[3-(1-Benzhydryl-5-chloro-2-{2-{2-(2,6-dimethyl-piperidin- 1-ethaanesulfonylamino]-ethy1}-1H-indol-3-ylH)ropy1]-berizoic acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and 2,6-dimethylpiperdine according to the procedure in Example 100 step 2 except tHat it was refluxed for heated at 80 *C for 1d17h, in 59 % yield. Step2: The ester intermediate was hydrotyzed according to Step 8 Example 1 to afford the title acid in 86% yield, m/z (M-1) 724.20. HRMS calc for [C42H48CIN3O4S] 724.29813 found 724.29776. Example 102:4-{3-1-enzhydryl-5H:hloix)-2-{2-[2H3,5-dimethyl-pyrazol- 1-)-thanesutfonylamino]-ethyl}-1H-indol-3-yl)-propyl]-benzoic acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and 3,5-dimethyl-IH-pyrazole according to the procedure in Example 100 step 2 except tHat it was refluxed for heated at 80 *C for 1d, in quantitative yield. Step2- The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 89 % yield, m/z (M-1) 707.16. HRMS calc for [C40H41CIN4O4S -H] 707.24642 found 707.24597. Example 103 and 104:4-{2-{1-benzhydryl-5-chloro-2-{2-(2- tetrazol-2-yl- ethanesulfonylamino)-ethyl]-1H-lndol-3-yl}ethoxy)benzoic acid and 4-(2-{1-benzhydryl-5-chloro-2-I2-(2-tetrazol-1-yl-etHanesulfonylamino)- ethyfJ-1H-indol-3-yl)ethoxy)benzoic acid Step 1: The mixture of 4-{2-{1-Benzhydryl-5-chloro-2-{2- ethenesutfonylamino-ethyl)-1H-indol)-3-yl]-ethoxyH)eruu)ic acid methyl ester (0.2 M, 1.0 equiv.), 1H-tetrazole(4.0 equiv.) and iPr2NEt(4.3 equiv.) in 1-propanol was nefluxed overnight It was evaporated to dryness before redissolving in EtOAc. The organic pHase was washed with water and brine, dried over magnesium sulfate, purified by column chromatography to give two isomers in 41% and 52% yields, respectively. Step2: The ester intermediates were hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acids 4-(2-{1- benzhydryl-5-chloro-2-[2-(2- tetrazol-2-yl-etHanesulfonvlajTiino)-ethyl-1H-indol-3- yl]ethoxy)benzoic acid in 92 % yield, m/z (M-1) 683.3; 4-(2-{1-benzhydryl-5-chloro-2-[2-(2- totrazol-1-yl- etHanesulfonylamino)-ethyl-1H-indol-3-yl}ethoxy)ben2oic 83%yidd. m/z(M- 1) 683.3. HRMS calc for [C35H33CINoO5S -H] 683.18489 found 683.18458; 4-(2-{1- benzhydryl-5-chloro-2-[2-(2- tetrazol-1-vl-etHanesiilfonylamino)-emyl]-1 H-indol-3- yl}ethoxy)benzoic acid in 83% yield. HRMS calc for [C35H33CIN6O5S -H] 683.18489 found 683.18435. The substituted nitro aromatic was treated with ethyl oxalate in the presence of potassium or sodium in an alcoholic solvent The resulting oxalate ester was treated with a suitable reducing agent, such as iron powder, and the resulting amine cyclized to the indole under the reaction conditions. The carboxytate was next reduced with any of a variety of reducing agents, lithium aluminum hydride, dibal etc and the resulting alcohol was oxidized using reagents such as manganese dioxide, Swem condition NMO/TPAP etc. This 2 formyl indote was next alkylated by treatment with a strong base such as Na/KHMDS, NaH, etc and then alkylated with a suitable Halide. The aldehyde was next treated with nitrometHane and a base such as ammonium acetate to yield a vinyl nitro intermednte tHat could be reduced by a variety of agents such as Lithium Aluminum Hydride or Zn(Hg) amalgam in HCI. The resulting amine was sulfonylated using a sutfonyl chloride either under bipHasic Schott and Baummen conditions or anhydrous conditions with an organic base. This intermediate could be reductively alkylated at C3 using an aldehyde or an acetal under the action of a Bronsted or Lewis acid such as trifluoroacetic acid and a reducing agent such as triethylsilane. The resulting intermediate was hydroJyzed using a base, NaOH, KOH, LiOH and a mixture of solvents including an alcoholic solvent, water and tetrahydrofuran. The following Examples 105-107 were synthesized using Method E. Example 105:4-2-{1-Benzhydryl-6-chloro-2-(2- phenytmetHanesulfbnylainino-ethyl) -1H-indol-3-yl]-ethoxy}-benzolc acid Step 1: To potassium (6.24 g) in ether at rt were added etHanoJ (40mL. in 100 mL ether), diethyl oxalate (27.85g, in 60 mL ether), and 4-chloro-2-nitrotoluene On 40 mL ether). The reaction mixture was stirred at rt for 15h and followed by sonication for 7h before pouring onto cold 1N HCI. After neutralization, the aqueous layer was extracted with EtOAc and the combined organic layers were washed with brine and dried. After evaporation, the crude 3-(4-Chlofc)-2-nitro-pnenyI)-2-oxo-propionic acid ethyl ester was used directly in the next step without further purification. Step 2: To crude 3-4-loro-2-riitrD-phenyl)-2-xo-propionic acid ethyl ester (151 mmol) in etHanol:glacial HOAc (1:1, v/v, 560 mL) at rt was added iron powder (74.4g) and the reaction mixture was stirred at reflux for 4h. The mixture was filtered and evaporated to give a residue which was redistributed in dichlorometHane/1N HCI. The organic layer was washed with 1N HCI, NaHCOj, and brine and dried. Evaporation followed by crystallization (DCM) gave 6-Chlon)1H-indole-2-carboxylic acid ethyl ester as a pale yellow solid (16.8 g, 50 % over 2 steps). Step 3: To 6-chloro-1H-indole-2-carboxylic acid ethyl ester (8.57g) in THF at 0 *C was added lithium aluminum hydride solution (1M, in THF) dropwise and the reaction mixture was stirred for 3.5h. The mixture was quenched with H20,15% NaOH, and H2O before it was filtered and rinsed with THF. Evaporation of the solvent gave 7.77 g of the crude (6-(-loro-1H-incloK2-yl)-metHanol which was used directly in the next step. Step 4: To (6-chloro-1H-indol-2-yl)-metHanol (37.7 mmol) in THF at 0°C was added manganese (IV) oxide and the mixture was stirred at rt for 16h. The mixture was tittered over ceite and rinsed with THF and EtOAc and evaporated to near dryness. The solid was filtered and washed with cold EtOAc/hex to give 6-Chloro- 1H-indole-2-carbaldehyde (62%, 2 steps). Step 5: To 6-chloro-1H-indote-2-carbaldehyde (1 equiv.) in DMF at 0°C was added NaH (1.25 equiv.) portionwise followed by benzhydryl bromide (1.46 equiv.) and B114NI (0.05equiv.). The mixture was stirred at rt for 42h before quenching with cold 0.4N HCL at 0 *C. After neutralization, the aqueous layer was extracted with ether and the organic layer was washed with cold H2O and dried. Flash chromatography on silica gel gave 14-benzhydryl-6-(chloro-1H-indole-2-carbaldehyde in 40% yield. Step 6: A solution of 1-benzhydryl-6-chloro-1H-indole-2-carbaldehyde (0.5M, 1 equiv.) and NH4OAC (1 equiv.) in nitrometHane was heated at 95 .C for 70 min. The mixture was diluted with EtOAc, washed with water, and dried. Evaporation of the volatiles, followed by trituration with ether/hexane produced 1-Benzhydryl-6-chloro-2- (2-nitro-vinyl)-1 H-indote in 48% yield. Step 7: To lithium aluminum hydride (1M in THF, 4 equiv.) in THF at O'C was added 1-ben2ydryl-6-chloro-2-(2-nitro-viny1)-1H-indole (0.1M, 1 equiv.) dropwise and the reaction mixture was stirred for 2h. The mixture was quenched with H20,15 % NaOH, and H2O, filtered through celtte and rinsed with EtOAc. After evaporation, the residue was purified by column chromatography to generate 2-(1-Benzhydryl-6- chloro-1H-indol-2-yl)-ethylamine in 40 % yield. Step 8: To 2-1-Benzhydryl-6-(-kxo-1H-indo(-2-yl)-ethyiamine was added phenylmetHanesulfonyl chloride according to the procedure in Example 1 Step 7 to generate -N-[2-1-Benzhydryl-6-chloro-1H-indol)-1H-indol-2-yl-)-ethyl]-C-phenyl- metHanesulfonamide in 90% yield. Step 9: To n2-(1-Benzhydryl-6-chloro-1HHndol-2-yl)-thyll-C-phenyI- rnetHanesutfonamide (0.033M, 1 equiv.) in DCM at 0*C were added 4-(2-oxo-ethoxy)- benzoic acid methyl ester (3.3 equiv.), triethytsilane (6 equiv.), and TFA (5 equiv.). The reaction mixture was stirred at rt for 2d 20h before aqueous workup. Purification by silica gel chromatography followed by reverse pHase HPLC gave 4-{2-{1- Ben-ydryl-6K-oro-2-(2-pheny1metHanesulfonyiamirx-thyl)-1H-rKlol-3-yl}-ethoxy}- benzoic add methyl ester in 35 % yield. Step 10: The ester intermediate from step 9 was hydrolyzed according to Step 8 Example 1 to afford the title acid in 64 % yield. Example 106: 4-(2-1-Beruhydryl-6-chloro-2-(2-(3,4-dichloro- phenyfmetHane sulfonylainino)-ethyl]-1H-indol-3-l}-ethoxy)-benzoic acid Step 1: To 2-{1-Benzhydryl-6-chloro.1H-indol-2-y1)-ethylamine, Example 105 step 7 was added (3,4-dicWoro-phenyl)-metHanesutfonyl chloride according to the procedure in Example 105 Step 7 to generate N-{2-(1-benzhydryt-6-chloro-1H-indol- 2-yl)-ethyt)C-(3r4-k-k)rc)-phenyl)-etHanesulfonamide in quantitative yield. Step 2: N-r)(1-Benzhydryl-6K*loro-1l+ex- phenyl)-metHanesulfonamide was reductively alkylated as described in Example 105 step 9 to give 4-2--benzhydryl-6-chloro-2--3,4-dichloro- phenyln)etHaiiesulfoi)ylamirK))-yl]-11h-indol-3-yl}-ethyl)-benzoic acid methyl ester in 38 % yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 96 % yield, m/z (M-1) 747.27. Example 107: 4-(2-{1-Benzhydryl-6-chloro-2-[2-(3,6-dlchloro- phenyimetHane eulfonylaimlno)-ethyfl]-1H-indol-3-yl}thoxy)-benzolc acid Step 1: To 2-1-Berizhydryl-6-oro-1H-ndol-2-yl)-ethylamine, Example 105 step 7 was added (3,5(lichk)ro-phenyl)-metHanesulfonyl chloride according to the procedure in Example 105 Step 7 to generate N2-14)enzhydryl-6-chloro-1H-indol- 2-yl)-ethyl}(K3,5KlicMoroi)rienyl)-metHanesulfonamide in quantitative yield. Step 2: N-1-Benzhydryl-6-chloro-1h-indol-2-yl-indol-2-yl)-ethyl-c-(3,4-dichloro phenyl)-netHanesulfonamide was reductively alkylated as described in Example 105 step 9 to give 4-(2-1-berizhydryl-6-chloro-2-[2-3,5-dichloro- prenylmetHanesulfonylamino)-ethyl] 1H-indol-3-yl-ethoxy)-benzoic acid methyl ester in 31 % yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 95 % yield. HRMS calc for [C39H33Cl3N2O5S+Na] 769.1068 found 769.1079.. Example 108: 4-(2-[1-Benzhydryl-5-chloro-2-(2-{[(2- cyanobenzyl]sulfnyl] amino}ethyt)-1H-indol-3-yl]ethoxy}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 2-bromomethyl- benzonitrile according to the procedure in Example 18 Step 1-2 in 100% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-{2-[2-(2-aminoethyl)-benzhydryl-5-l-1H-indol-3-yl]ethyl}benzoate(Step6, Example 1) according to the procedure in Example 1 Step 7. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title add in 72% overall yield. HRMS calcd. for C40H35CIN3O5S (M+1): 704.1980; found: 704.1984. HRMS calcd. for C40H35CIN3O5S (M+1): 704.1980; found: 704.1984. Example 109: 4-{241-Benzhydryl-5-chk)ro-2-(2-a(tetrahydro-2H-pyran-2- ylmethyl) sulfonyf]amlno}ethyl)-1H-indol-3-yl]etlioxy}benzoic acid Step 1: The sulfonyl chloride intermediate was prepared from 2- bromomethyl-tetranydro-pyran according to the procedure in Example 18 Step 1-2 in 100% yield. Step 2: The methyl ester was prepared from the sutfonyl chloride and methyl 4-{242-2-aminoemy!M-benzhydry1-5--- (Step6, Example 1) according to the procedure in Example 1 Step 7. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 20% overall yield HRMS calcd. for C3eH3sCIN2O6S (M-1): 685.2145; found: 685.2143. Example 110: 4-{2-{1-Benzhydryl-2-(2-{[(1,3-benzoxazol.2-ylmethy1) sulfonyl]emino)ethyl)-5-chloro-1H-lndol-3-yrjethoxy)benzoic acid Step 1: The sutfonyl chloride intermediate was prepared from 2- bromomethyi-benzooxazole according to the procedure in Example 18 Step 1-2 in 100% yield. Step 2: The methyl ester was prepared from the sutfonyl chloride and methyl 4-2-2-[2-aminoethyf)-14)en2hydryl-5-loro-1H-indol-3-yl]ethoxy}ben2oate(Step6, Example 1) according to the procedure in Example 1 Step 7. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 26% overall yield. HRMS catad. for C40H35CIN3O6S (M+1): 720.1930; found: 720.1924. Example 111: 4-{2-{1-Benzhydry1-5-hloro-2-(2-{[(cyanomethyl)sulfonyl] amino)ethyl)-1 H-indol-3-yl]*hoxy}benzolc acid Stepi: The sulfonyl chloride intermediate was prepared from 3- bromomothyl-1,2,4]oxadiazote according to the procedure in Example 18 Step 1-2 in 100% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-2-2-aminoethyl)-1-benzhydryl-5-chloro 1H-indol-3-yl]ethyl}benzoate(Step6, Example 1) according to the procedure in Example 1 Step 7. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 59% overall yield. HRMS calcd. for C34H31CIN3O5S (M+1): 628.1668; found: 628.1662. Example 112: 4-{2-{1-Benzhydryl-5-chloro-2-(2-{[(3- thienybnethyl)suHbnyfJ emino}ethyl)-1H-indol-3-yl]ethoxy}benzolc acid Step 1: The sutfonyl chloride intermediate was prepared from 3-bromomethyl 3-bromomethyf-thiophene according to the procedure in Example 18 Step 1-2 in 100% yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 442-2-amino)ethyl}-14)enzhydry-5-chlo-1H-indol-3-yl]ethyl}benzoate(Step6, Example 1) according to the procedure in Example 1 Step 7. Step 3: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 25% overall yield. HRMS calcd. for C32H31ClN2O5S- (M-1): 683.1447; found: 683.1445. Example 113: 4-{2-1-Benzhydryt-6-chloro-2-(2-[2-{2-m©thyl-pyiTolidin-1- yl)-etHanesutfonylamino]-ethyl}-1 H-indol-3-l)-ethoxy]-benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 2-methyJ-pyrrofidine according to the procedure in Example 87 step 2 in 91% yield. Step2: The ester intermediate was hydroiyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 99 % yield. HRMS calc for [C39H42CIN3O5S -H] 698.24609 found 698.24572. Example 114:4--1-enzhydryl-5-chloro.2-{2-[2-{2-methyl-piporidin-1- yl)-ethanesulfonylamiro)]-thyl-1H-ndol-3-yl)-ethoxy]-benzolc acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 2-methyf-piperidine according to the procedure in Example 87 step 2 in 91 % yield. Step2: The ester intermediate was hydroiyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title add in 96 % yield. HRMS calc for (C40H44CIN3O5S -H] 712.26174 found 712.26113. Example 115: 4-(2-1-Benzhydryl-5-chk)ro-2-{2-{2-(2,5-dimethyl- Pyrrolidin-1-)-tHane8ulfonylamiiK)]-thyfh1HHndol-yl)-thoxy]-benzoicacld Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 2,5-dimethyl-pyrrolidine according to the procedure in Example 87 step 2 in 81 % yield. Step2: The ester intermediate was hydroiyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 96 % yield. HRMS calc for [C4oH44CIN306S -H] 712.26174 found 712.26114. Example 116: 4-(2-{1-Benzhydryl-5-chloro-2-I2-(2-fhiomorpholin--yl- etHanesulfonylamino)-ethyl]-1 H-indoi-3-yf}-ethoxy)-benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and thiomorphoiine according to the procedure in Example 87 step 2 in 93 % yield. Step2: The ester intermediate was hydroryzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title add in 90 % yield. HRMS caic for [C36H40CIN3O5S2 -H] 716.20251 found 716.20217. Example 117: 4-(2-(1-Benzhydryi-5-chloro-2-{2-(2-piperidin-1-yI-etHane eulfonylamino)-ethya-1H-indol-3-yr}-ethoxyH)enzolc acid Step 1:The compound was prepared from the intermediate from Example 87 step 1 and piperidine according to the procedure in Example 87 step 2 in 99 % yield. Step2: The ester intermediate was hydroryzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 92 % yield. HRMS calc for [C39H42CIN3O6] 698.24609 found 698.24570. Example 118: 4K2-1-benzhydryi-5-chloro-2-[2-o4orylsulfenylrnetnane sulfnylamino-ethyl)-1H-indol-3-yl]-ethoxy)-benzoic acid Stepi: To methyl 4-{2-{1-benzhydry)-5-chloro-2-{2-{I(chloromethyl5Ulfonyl] amino)ethyrh)1H-indol-3-rjethoxy}benzoate, Example 81 stepi, was added o- thiocresol according to the procedure in Example 81 step 2 and 3. The product was purified by the preparative HPLC in 45% yield. Step2: The ester intermediate was hydroryzed according to Step 8 Example 42 to afford the title add in 98% yield, m/e (M-1)723.07. HRMS calc for [C4oH37CIN205S -H] 723.17596 found 723.17596. Example 119: 4-(2-14)erizhydiyl-5-hlorx)-2-[2-(2-chloro-phenyl8ulfanyl metHanesulfbnylamino)- ethyl]-1H-lndol-3-yl} -othoxy)-benxolc acid Stepi: To methyl 4-{2-[1-benzhydryl-5-chloro-2-(2- {[(chloromethyl)sulfonyi]amino}ethyl)1H-indol-3-yf|ethoxy}ben2oate, Example 81 stepi, was added 2-chorothio)phenol according to the procedure in Example 81 step 2. The product was purified by the preparative HPLC in 53% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title acid in 100% yield, m/z (M-1)743.08. HRMS calc for [C39H34Cl2KN2O5S2 -H] 743.12134 found 743.12111. Example 120: 4-(2-(1-benzhydiyl-5-chloro-2-{2-(2I6-dichloro- phenyteulfanyl metHanesidfonylamfno)- ethyl]-IH-indol-3-yl } -ethoxy)-benzoic acid Stepi: To methyl 4-{2-{1-benzhydryl-5-ch!oro-2-(2- {[(chloromethyl]sulfonyl]aminolethyl)-1H-indol-3-yl]ethoxylbenzoate, Example 81 stepi, was added 2,6-dichlorothiophenol according to the procedure in Example 81 step 2. The product was purified by the preparative HPLC in 15.7% yield and hydrolized add in 37%. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title add in 98% yield, m/z (M-1) 776.93. HRMS calc for [C39H33Cl3N2O5S2 -HI 777.08237 found 777.08205. Example 121: 4-{2-{1*enzhydryl-6-chlorx)-2-{2-(2,5-imethoxy- phonylsuHanyl metHanesutfonyiamino)- ethyf]-1H-indol-3-yl } -ethoxy)-benzoic add Stepi: To methyl 4--1-berizhydryl-5-chloro-2-[2-(chloromethyl)sulfonyl] amino)ethyl)-1H-indol-3-yllethoxy}benzoate, Example 81 stepi, was added 2,5- dimethoxythiophenol according to the procedure in Example 81 step 2. The product was purified by the flash chromatography 35% EtOAc/hexane in 65% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title add in 99.5% yield, m/z (M-1)769.18. HRMS calc for [C41H39CIN2O7S2 -H] 769.18144 found 769.18121. Example 122: 4-{2-(14)enzhydryI-5-chloro-2-{2-I2-(3-hydroxy-pyrrolidJne- 1-yl)-etHaneeurfonylaminol-ethy-1H-lndol-3-yl)-ethoxy]-benzoicacid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 3-pyrrolidinol according to the procedure in Example 87 step 2 in 90 % yield without the column purification. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 84 % yield, m/z (M-1)699.99. HRMS calc for [C38H40CIN3O6S -H] 700.22535 found 700.22490. Example 123: 4-p-1-Bonzhydryl-5-chlofo-2-{2-I2-(4-hydroxyi)lperidln-1- yl)-etHaneeurfonyiamino]-ethyt}-1H-indol-3-yl)-ethoxy]-benzolc add Step 1: The compound was prepared from the intermediate from Example 87 step 1 and 4-hydroxypiperidine according to the procedure in Example 87 step 2 in 95 % yield without the column purification. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title add in 42 %yield. m/z (M-1)714.03. HRMS calc for [C39H42CIN3O6S -H] 714.24100 found 714.24085. Example 124: 4-{2-(1-Benzhydryi-5-chloro-2-{2-P-(2- dirnethytaminomethyl-pipei1dIn-1-yl)-etHan yl)-ethoxy]-benzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and -2-peridylrnethyl)-dimethylamine according to the procedure in Example 87 step 2 in 90% yield without the column purification. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5. to afford the title acid in 71% yield, m/z (M-1)754.94. HRMS calc for [C42H49ClN4O5S -H] 755.30394 found 755.30344 Example 125: 4-(2-{1-Benzhydryl-5-chloro-2-{2-(2-imidazol-1-y|- etHanesulfony1amJno)-ethyi].1H-indol-3-yI)-ethoxy)-bonzoic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and imidazoleaccording to the procedure in Example 87 step 2 except tHat it was heated at 120°C for 4.5 days, in 87 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 60 % yield, m/z (M-1)681.17. HRMS calc for [C37H35CIN4O5S -H] 681.19439 found 681.19409. Example 126:4-{3-[1-ben2hydryl-5-chloro-2-(2-{[(2,6- difluorobenzyl)suHbnyl] amino}ethyl)-1H- indol-3-yl]propyl)benzoic acid Step 1: The sulfonyl chloride intennediate was prepared from 2,6- difluorobenzyl bromide according to the procedure in Example 18 Step 1-2 in quantitative yield. Step 2: The methyl ester was prepared from the sulfonyl chloride and methyl 4-2-2-aminoethylH-benzhydry-5-chloro-1H-indol-3-yl]propyl}benzoate(Step 6, Example 42) according to the procedure in Example 1 Step 7 in 53% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 92% yield, m/z (M-1)711.2. HRMS calc for [C40H35CIFN2O4S -H] 711.19013 found 711.18965. Example 127:4-{3-[1-benzhydryl-2-(2-{[(3)4-dichlorobenzyl)- sulfonyl]amino}ethyl)-1H-indol-3-y1]propyl}benzoic add Step 1:2-rnethylindote was treated with the intermediate from Example 42 stepi and the procedure from Example 42 step 2 to yield the desired product in 88%. Step 2: The product from above was alkylated with benzhydryl bromide according to the proceure in Example 42 step 3 to yield the product in 65%. Step 3: The product from above was oxidized using the conditions outlined in Example 42 step 4 to yield the desired 2-formyl indole in 85% yield. Step 4: The indole from above was subjected to the nitro aldol conditions outlined in Example 42 step6 Step 5: The vinyl nitro compound from above was reduced under the conditions outlined in Example 42 step 6 to yield the desired amino indole in 39% yield. Step 6: The amine from step 5 was treated with (3,4-dichlorophenyl)- methyl]sulfonyl chloride according to the procedure in Example 43 Step 7 which yielded 100% of the desired product Step 7: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title acid in 24% yield. HRMS calc for [C-CIN2O4S -H] 709.1700 found 709.16951. Example 128: 4-(3-14)erizhydryl-2-2H;(benzytsulfonyl)amino]ethyr)-1H- indol-3- yl)propyl]benzolc add Step 1: This compound was prepared from the intermediate in Example 127 step 5 a-toluenesulfonyl chloride according to the procedure in Example 43 Step 7 which yielded 83% of the desired product. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 42 to afford the title add in 95% yield. HRMS calc for [C40H35N2O4S-H] 641.24795 found 641.24761. The appropriately substituted Halo amine is reacted with trifluoroacetic anhydride to yield an intermediate that could be treated with a Pd" catalyst in the presence of a base such as triethlyamine and Cul and a suitable alkyne under heat yielded the desired tndote intermediate. The primary alcohol was protected as a silyl ether using a silyl chloride such as t-Butldiphenyl silyl chloride and a base such as imidazole. The protected indote is then treated with oxallyl chloride followed by metHanol which produced the desired oxalate ester which could be alkylated using a suitable base such as cesium carbonate in refluxing acetonitrile and a halide. The oxallate could then be reduced via the action of a suitable reducing agent such as borane. The resulting primary alcohol was converted to a Halide, using for example CBr4 and a phosphine, which could then be a nucleophile such as a thiophenol. The resulting thoether could be oxidized by a variety of oxidizing agents including oxone and TPAFVNMO. The resulting sulfone can be deprotected via the action of a flouride source such as TBAF, CsF or HF. The resulting alcohol could be converted to a Halide or mesylate, for example using metHane sulfonyl chloride and an organic base, which could then be displaced by sodium azide in DMF.The resulting alkyl azidee could be reduced under the action of triphenyl phosphine and wet THF. The amine could be sulfonylated by the action of a sulfonyl chloride under either bipHasic Shcott and Baumman conditions, Aq. Bicarbonate and dichlorometHane, or under anhydrous conditions consisting of dichlorometHane and an organic base such as Hunigs base. The resulting intermediate was hydrolyzed using a base, NaOH, KOH, lioOH and a mixture of solvents including an alcoholic solvent, water and tetrahydrofuran. The following Examples 129-132 were synthesized using Method F. Example 129:3-{4-({2-[1-Benzhydryl-5-chloro-2-(2-a(2-chloro- benzyl)sulfonyl] amino}ethyl)-1H-indo]-3-yl]ethyl}sulfonv1)phenyfJ propanoic acid Step 1:2-Bromo-4-chloroaniline(1.0eq) was dissolved in CH2CI2 (0.25M), then triethylamine and triflouroacetyl anhydride(1.1eq each) were added. The resulting mixture was stirred at room temperature for 1 hour. Solvent was then stripped-off from the reaction mixture, and the residue was purified by flash chromatography with dichlorometHane as eluent to give the described product in 97% yield. m/z(M-H)' 300.0. Step 2: N-(2-Bromo-4-chloropheny1)-2,2)2-trifluoroacetamide(step 1, LOeq) was mixed with 3-butyn-1-ol(Z0eq), dichlorobis(triphenylphosphine)palladium(ll) (2.5%eq). triethylamine(3.0eq), Cul(5%eq) in DMF(0.2M) in a sealed vessel under N2 and heated to 120°C for 4 hours. The reaction mixture was then diluted with ethyl acetate, washed with brine and dried over Na2SO4 Furthermore, evaporate the solvent and the residue was purified by flash column chromatography with 2% MeOH/CH2Cl2 to give the described product(A) in 67% yield. m/z(M-H)*194.09 Step 3:2-(5-hloro-1H-indol-2-yl)ethanol(step 2, LOeq) and imidazole(2.0eq) were dissolved in DMF(0.3M) at room temperature with stirring beforetert- butylchlorodipnenylsilane (1.2eq) was added. The resulting mixture was kept stirred overnight at room temperature before it was quenched with a saturated sodium bicarbonate aqueous solution and extracted with ethyl acetate. Organic pHase was washed with water and brine and dried over Ns-SO* Solvent was removed and residue was purified with column with CH2CI2 as eluent to give the desired product as brown gum in over 90% yield. m/z(M-H)*433.0 Step 4:2-{Itert-Butyl(dipn2y0silynoxy}ethy1)-5-loro-1H-indote(step 3, 1 .Oeq) was dissolved in ether (0.4M) and the solution was cooled to 0°C. Oxalyl chloride (1.2eq) was added to the above cold solution with vigorous stirring. The reaction mixture was kept stirred at 0°C for 1 hour before EtOH was added, followed by NEts. The resulting mixture was then diluted with more EtOH before it was poured into water. Extract with EtOAc. Organic pHase washed with brine, dried over Na2SO4, concentrated to give the desired product as yellowish solid in 70% yield. m/z(M-H)" 533.0 Step 5: Ethyl p-fltert-butyl(diphenyI)silyl]oxy}ethyl)-5-chloro-1H-indol-3- yl](oxo)acetate(step 4,1eq), PHaCHBrCI.Seq) and C82CO3(1.6eq) were mixed in dry acetonitrile (0.1 M). The mixture was refluxed with stirring for 2 hours. The reaction mixture was cooled to room temperature, added water and extracted with EtOAc. Organic pHase was concentrated and the residue was columned with CH2CI2 as eluent to give the desired product as orange gum in 45% yield. nVz(M+H)*701.3 Step 6: Ethyl [1-rchydryl-2-({Itert-butyKdiphenyl)silyl]oxy}ethyl)-5-chloro- 1H-indol-3-yl] (oxo)acetate(step 5,1eq) was dissolved in THF (0.1M), then BH,.Me2S (2M in THFX2eq)was added to it The resulting mixture was refluxed with stirring overnight under N2. The reaction mixture was cooled to room temperature, then quenched slowly with 1N NaOH. Followed by EtOAc extraction, brine wash. Striping- off the solvent to give the described product in 65% yield. m/z(M+H)*645.0 Step 7: 241-Benzhydry1-2-({Itert-biJty1(diphenyl)silyloxy}ethyl)-S(hloro-1H- indol-tyl]etHanol (Step 6,1eq) was dissolved in CH2Cl2.O8M). then 1,3- bis(dipnenylphosphino)-propane (DPPP. 0.75eq) was added. The solution was cooled to 0°C under N2, then CBr4 (1.25eq) was added with stirring. The stirring was continued for 2 hours while the reaction temperature was allowed to return to room temperature. The solvent was stripped off, and the residue was purified by passing through a short column with CH2Cl2 as eluent to give the desired product in quantitative yield. m/z(M+H)*708.0 Step 8:1-Benzhydryi-3-2-bromoemy1)-2-({[tert-butyl(diphenyl)seyl]oxy}ethyl)- 5-chloro-1H-indole(Step 7,1eq) was mixed with methyl-3-{4- mercaptolphenyl)propionate (1.5eq) and K2CO3 (1.5eq) in DMF(0.1M). The resulting mixture was stirred at room temperature under N2 for 2hrs, then water was added, foBowed ethyl acetate extraction, brine wash, and column purification (CH2Cl2 as eluent) to give 80% of the desired product as brownish gum. m/z(M+H)823.0 Step 9: Methyl 3-4-{2-1-benzydryl-2-({Itert-butyl(diphenyl)sily1}oxy}ethyl)- 5-chloro-1H-indol-3-yl]ethyl}sulfanyl)phenyl]propanoate (Step 8.1eq) was dissolved in asetonitrile(0.1M), then molecular sieve (powder, 4 A,) and 4-methylmorphorline N- oxide(NMO)(4eq) were added under N2. After 5 min, n-Pr4NRu04 (TPAP)(5%eq) was added to it The resulting mixture was heated to 40°C with stirring and kept for 1.5hrs. Strip-off the solvent, residue was columned with CH2CI2. then 1%EtOAc/CH2CI2 as eluent to give the desired product as white foam in 44% yield. m/z(M+H)*855.1 Step 10: Methyl 3-(4-{2-{1-benzhydryl-2-(atert-butyl(dipnenyl)silyl]oxy}ethyl)- 5-chloro-1H-indol-3-y1]ethoxy}pheny1)propanoate (Step 9,1eq) was dissolved in THF(0.1M) and cooled to 0°C, followed by nBu,NF (1M in THF) (1.2eq). The resulting mixture was stirred at 0°C for 5', then warmed up to room temperature and stirred for 30'. Strip-off solvent. The residue was columned with EtOAc/CH-b (1:9 to 1:4) as eluent to give the described intermediate as white foam in 90% yield. mfe(M+Hr616.20 Step 11: Methyl 3-{4-{2-{1-ben2hydryl-5-chloro-2-(hydroxyethyl)-1HHndol-3- yl]ethyl}-sulfonyl)phenyl] propanoate(step 10,1eq) in dichlorometHane(0.02M) was treated at 0°C with MeSOjCI (2.0eq) and Et3N(2.5eq) and stirred for 1 hour. The ice- bath was removed and the reaction mixture was stirred for another 1 hour at room temperature before it was diluted with CH2CI2, washed with NaH2PO4 .brine and dried over Na2SO4. Evaporate solvent to give the described product in quantitative yield. m/z(M+H)+695.0 Step 11: Methyl 3-{4-a2-(1-ben2hydryJ-5-chloro-2-{2- [(methyteutfonyl)oxy}ethyl}-1H-indo-3-yl)ethyl]sulfonyl}phenyl)popanoate(step11. 1.0eq) was dissolved in DMF(0.03M) and treated with NaN, (3.0eq). The resulting mixture was heated to 60 °C and stirred for 2 hours, then, was added water, extracted with ethyl acetate, washed with brine and dried with Na2SO,. Evaporation of solvent yields quantitatively the described product, m/z (M+H)*641.1. Step 12:. Methyl 3-{4-{{2-{2-(2-azidoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]ethyl} sulfonyl)phenyl]propanoate(step 12,1eq) was dissolved in THF(0.1M), and treated with triphenylphosphine(1.1eq). The reaction mixture was kept stirred for 2 days before the addition of water, then stirred overnight. Strip off solvent, residue was columned with 4%MeOH:CH2CI2 as eluent to give the described product in 71% yield. m/z(M+H)+615.2 Step 13: Methyl H-{2-{2-(2-eninoethyl]-1-benzhydryl-5-chloro-1H-indol-3- yl]ethyT) sulfonyl)phenyl]propanoate(step 12,1eq) and (3,4-dichlorobenzyl)sulfonyl chloride(1.1) were dissolved in CH2Cl2(0.1M) at room temperature, then aqueous Na2CO3 solution was added with stirring. The stirring was continued for 2 hours. Then, organic pHase was separated, washed with brine, dried with Na2SO4. Evaporate the solvent, the residue was columned with CH2CI2 to 2%MeOH: CH2CI2 as eluent to give 85% yield of the described product as white solid. m/z(M-H)-834.9 Step 14: Methyl 3-{4-({241-benzhydryi-5-chloro-2-(2-{I(3)4- dichlorobenzyl]sulfonyl]amino} ethyl)1 H-indol-3-yl)ethyf}sulfony0phenyrjpropanoate (step 13,1.0eq) was dissolved in THF:MeOH (1:1) (0.1M). then added 1N NaOH. The mixture was kept stirred overnight at room temperature. The solvent was stripped off and the residue was dissolved in water to form a basic solution, which was neutralized with diluted HCI solution to precipitate the product. The solid was collected by filtration, washed with water, rinsed with hexane, then dried to give the desired product in 86% yield. HRMS calc for [C41H37CI3N2O6S2 +HJ 823.12314 found 823.12292. Example 130:3-4-{P-(1-Benzhydryl-2-{2-{(berizylsulfony1)afnino]ethyl}- 6-chloro-1H-lndol-3-y1)ethyl]sulfony1}phenyl)propanoic acid Step 1: The intermediate from example 129, step 12 was treated with ct- toluenesulfonyl chloride according to the procedure in example 129 step 13 to yield the desired compound in 94% yield. Step 2: The intermediate from above was treated with NaOH according to the procedure described in example 129, step 14 to yield the desired acid in 92% HRMS calc for [C41H39CIN2O6S2 +H] 755.20109 found 755.20201. Example 131:3-[4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2)6- difluorobenzy1)8ulfonyl] amlno}ethyt)-1H-indol-3-yl]ethyl} sulfonyl)phenyl]propanoic acid Step 1: The intermediate from example 129, step 12 was treated with (2,6- Difluoropbenyl)-metHanesulfony1 chloride according to the procedure in example 129 step 13 to yield the desired compound in 42% yield. Step 2: The intermediate from above was treated with NaOH according to the procedure described in example 129, step 14 to yield the desired acid in 83%. HRMS calc for [C41H37CIF2N2O6S2 +H] 791.18224 found 791.18257. Example 132:3-[4-({2-[1-benzhydry1-5-chloro-2-(2-{[(2- fluorobenzyl]sulfbnyl] amino)ethy!)-1 H-indol-3-yl]ethyl}sulfonyl)Dhenyl] propanoic acid Step 1: The intermediate from example 129, step 12 was treated with (2- fluoro-phenyl]-metHanesulfonyl chloride according to the procedure in example 129 step 13 to yield the desired compound in 42% yield. Step 2: The intermediate from above was treated with NaOH according to the procedure described in example 129, step 14 to yield the desired acid in 86% yield. HRMS calcfor[C41H38CIF2N2O- +H] 773.19166 found 773.19213. An intermediate from Method F could be alkylated at the C3 position with aldehydes or the corresponding acetate in the presence of a Lewis or Bronsted acid, such as boron triflouride etherate or trifluoroacetic add. The indole nitrogen may then be alkylated by treatment with a strong base such as sodium bis(trimethylsilyl)amide, n-BuU, sodium hydride or potassium hydride in a solvent such as DMF, DMSO or THF followed by exposure to the appropriate Halide. The resulting thioether could be o)ddized by a variety of oxidizing agents including oxone and TPAP/NMO. The resulting sulfone can be deprotected via the action of a ftouride source such as TBAF, CsF or HF. The resulting alcohol could be converted to a Halide or mesylate, for example using metHane sulfonyl chloride and an organic base, which could then be displaced by sodium azide in DMF.The resulting alkyl azide could be reduced under the action of triphenyl phosphine and wet THF. The amine could be sulfonylated by the action of a sulfonyl chloride under either DipHasic Shcott and Baumman conditions, Aq. Bicarbonate and dichtorometHane, or under anhydrous conditions consisting of dichlorometHane and an organic base such as Hunigs base. The pesuto'ng intermediate was hydrolyzed using a base, NaOH, KOH, LiOH and a mixture of solvents including an alcoholic solvent, water and tetrahydrofuran. The following Examples 133,135-138 and 140-141 were synthesized by Method G. Example 133:3-[4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2- chlorobenzyl)sulfony1]amino}ethyl)-1H-indol-3-l}ethyl}sulfonyl)phenyl] propanoic acid Step 1: Ethyl 4-{(2-oxoethyl)sulfanyl]propanoate (example 129 step 3,4.2eq) was added to a solution containing 2-{Itert-butyl(diphenyl)sily0oxy)ethyl)-5-chloro- 1H-indole (1eq). TFA (3eq), and 1,2-dichloroetHane (0.1 M) at 0°C under N2. Then EtsSiH (12eq) was added and the reaction was alowed to return to room temperature and stirred overnight Quenched reaction with NaHCO3(aq) and extracted with EtOAc and washed with brine and dried over sodium suffate. Purified with silica gel column and 1:5 EtOAc/Hexane as eluent Obtained ethyl 4-({2-[2-(2-{[tert- butyl(diphenyl)sily1]oxy}ethyl)-5-chloro-1H-indol-3-l}ethyl}sulfonyl)propanate (yellow oil) in 79% yield. Step 2: Ethyl 4-({2-2-[2-atert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1H-indol- 3-yfJethyl}sulfanyr)propanoate (1eq) was added to a suspension of NaH (1.1 eq) in DMF (0.38M) at 0°C under N2. After 30 minutes PhjCHBr was added and the reaction was warmed to room temperature. After 2.5 hours the reaction was quenched with NH4Cl(aq)- and extracted with EtOAc/EfeO mix and washed with water and brine and dried over sodium suffate. Purified with silica gel column and 1:6 EtOAc/Hexane. Obtained ethyl 3-{4-({2-{1-benzhydryl-2-(2-atert- butyl(dipbenyl)silyl]oxy}ethyl-5-lo- (yellow gum) in 42% yield. Step 3: NMO (4eq) was added to a solution/suspension containing ethyl 3-{4- ({241-beruhydryl-2-(2-{[tert-butyl- yl]ethyi}sulfanyl)phenyl]propanoate (1eq), ACN (0.1M), and molecular sieves (1g/mmole of propanoate) under N2. After 10 minutes TPAP (0.05eq) was added and the mixture was heated to 40°C. After 2 hours the reaction was cooled and filtered and the filtrate was collected. Purified with silica gel column and 1:4 EtOAc/Hexane. Obtained ethyl 3-{4-({2-{1-ben2hydry(-2-(2-atert-butyJ(diphenyl)silyf]oxy}ethyI}-5- chloro-1H-indol-3-yI]ethy1}sutfonyl)pheny1]propanoate (white solid) in 86% yield. Step 4: Tetrabutytammonium fluoride (1M in THF) (1.2eq) was added to a solution of ethyl 3-{4-({2-I1-benzhydryl-2-(2-{Itert-butyl(diphenyl)silyI]oxy)ethy1)-5- chloro-1H-indol-3-yl]ethyi}suffonyl)phenyJJpropanoate (1eq) and THF (0.1M) at 0°C under N2. Warmed reaction to room temperature and after 30 minutes quenched with NK4Cl(aq). Extracted with EtOAc and washed with brine and dried over sodium sulfate. Purified with silica gel column and 1:9 EtOAc/CHaCl2. Obtained ethyl 3-[4-({2- [1-benzhydryl-5(hloro-2-(2-hydroxyethyl)-1H-indo)-3- vf]ethy1}sutfonyi)pnenyf]propanoate (white solid) in 88% yield. Step 5: CH3SO2CI (2eq) and Et,N (2.5eq) were added to a solution of ethyl 3- [4-{2-1-benzhydryl-5-chloro-2-(2-hydroxyethy1)-1H-indo(-3- yl)ethyl}surfonyl)phenyl]propanoate (1eq) in CHjCfe (0.02M) at 0°C under N2. After 1 hour the reaction was warmed to room temperature. After an additional hour water was added and extracted with CH2CI2 and washed with brine and dried over sodium sulfate. Removed solvent to obtain ethyl 3-(4-{[2-(1-benzhydryt-5-chloro-2-{2- [(methylsu!fonyl)oxy]ethyf}-1 H-indol-3-yl)ethyl]sulfonyl}phenyl)propanoate (white solid) in 08% yield. Step 6: Ethyl 3-4-2-[1-benzhydryf-5-chk)ro-2-2-(methyJsulfonyl)oxyJethyl)- 1H-indol-3-yl)ethyl]sulfonyJ}pheny1)propanoate (1eq), sodium azide (5eq), and DMF (0.05M) were placed together under N2 and heated to 60°C. After 1 hour the reaction was cooled and water was added. Extracted with EtOAc/EfcO mix and washed with water and brine and dried over sodium sulfate. Removed solvent to obtain ethyl 3-{4- ({2-2-2-azid(-hy1)-1-benzhydry1-5-chloro-1H-indol-3- yl]emyl]sulfonyl]phenyl]propanoate (light-brown solid) in 96% yield. Step 7: Ethyl 3-4-{2-2-2-azidoemyl-1-berizhydry1-5-chlorc)-1H-indot-3- y|]ethyl}sulfonyl)pheny|]propanoate (1eq), PPhj (polymer supported) (1.3eq), and THF (0.1M) were placed together under N2. After 3 days water (1ml71mmole propanoate) was added and reaction was stirred overnight. Rltered and collected filtrate. Purified with silica gel column and 2% MeOH in CH2CI2 Obtained ethyl 3-[4- ({2H2-2-aminoethyl)-1-benzhydry*-5-chloro-1H-indol-3- y1]ethyl}sutfonyl)phenyl]propanoate (light-brown solid) in 65% yield. Step 8: (2-chlorobenzyl)sutfonyl chloride (2.2eq) was added to a mixture of ethyl 3-[4-({2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]ethyf}sutfonyl)phenyl]propanoate (1eq), CH2O2 (0.08M), water (1mL/1mL CH2CI2), and Na2CO3 (2.5eq). After 2 hours more (2-chlorobenzyl)surfonyl chloride (1.1 eq) was added. After an additional 1.5 hours the organic layer was recovered and washed with brine and dried over sodium sulfate. Purified with silica gel preparatory plate and 2% MeOH in CH2CI2. Obtained ethyl 3-{4-({2-{1-benzhydryl-5-chloro-2-(2- {[(2-(*toroben2yl)sutfony0ammo}ethyI)-1H-indol-3-l}ethyl}sulfonyl)pr)enyl]propanoate (light-yellow gum) in 75% yield. Step 9: Ethyl 3-4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2- chtorobenzy1)surfonyl]amino}ethyl)-1H-indol-3-l}ethyl}sulfonyl) (1eq), THF (0.1M), MeOH (1ml71mL THF), and NaOH (1N) (11eq) were stirred together overnight Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI and collected resulting precipitate by filtration. Obtained 3-{4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2- chlorobenzy0sulfony|]amino}ethyl)-1 H-indol-3-yl]ethyl}sulfonyl)phenyI]propanoic acid (light-brown solid) in 83% yield. HRMS calc for [C39H36CIN3S +H] 789.16211 found 789.16311. The suitably substituted indole-2-cafboxylate could be reduced via a suitable reducing agent such as lithium aluminum hydride, dtbal etc and then the resulting alcohol could be oxidized to the 2-formyl indole using MnO2 under Swem oxidation conditions or other oxidants. The indole nitrogen may then be alkylated by treatment with a strong base such as sodium bis(trimethylsilyl)amide, n-BuLi, sodium hydride or potassium hydride in a solvent such as DMF, OMSO or THF followed by exposure to the appropriate Halide. The aldehyde was next treated with nitrometHane and a base such as ammonium acetate to yield) a vinyl nitro intermediate tHat could be reduced by a variety of agents such as lithium aluminum hydride or Zn(Hg) amalgam in HCI. The resulting amine was sulfonylated using a sulfonyl chloride either under bipHasic Schott and Baummen conditions or anhydrous conditions with an organic base. Treatment of the the resulting sulfonamide with a strong base such as sodium bis(trimethylsilyl) amide, rvBuLi, sodium hydride or potassium hydride in a solvent such as DMF, DMSO or THF followed by exposure to a silyl chloride such as t- butyldimethyl silyl chloride to generate the protected sulfonamide. This material could be formyiated at C3 using standard Vilsmeier conditions conditions of POCI3/DMF. The thus formed 3-fbrmyl indole was reductively aminated using a suitable amine, a reducing agent such as sodium triacetoxyborohydride and acid such as glacial acetic acid. The resulting intermediate was hydroJyzed using a base, NaOH, KOH, LJOH and a mixture of solvents including an alcoholic solvent, water and tetrahydrofuran. Example 134 was synthesized by Method H. Example 134: 4-({[(1-benzhydryl-2-(2-{(benzyl8ulfonyl)amino]ethyl)-5- chloro-1H-indol-3- yl)methyl]amfno}methyl)t)enzoic acid Step 1:5-Chloro-1H-indole-2-carboxyiic acid ethyl ester (1 eq.) was dissolved in THF (0.4M), flushed with a nitrogen atmosphere and then the mixture was cooled to 0°C and LAH (3 eq of a 1M solution in THF) was slowly added. The reaction was allowed to warm slowly to room temperature and stirred until TLC analysis indicated completion. After cooling the flask to 0°C, NaOH (60 ml 3N solution) was slowly added and the reaction stirred until two layers were obtained. The layers were separated, aqueous was extracted 2X ethyl acetate, the combined organics were washed with brine and then dried over magnesium sulfate and concentrated to yield the desired alcohol tHat was used crude for the next step. Step 2: The product (1 eq.) from above was dissolved in THF (0.5 M) and treated with manganese dioxide (3 eq), and stirred for 1.5 hours until TLC analysis indicated tHat reaction was complete. The reaction was filtered through ©elite, dried over magnesium sulfate, and concentrated to yield the desired crude aldehyde in 82% yield. Step 3: To the indole from above (1.0 eq) in DMF (0.36 M) at 25 *C was added NaH (1.2 eq, 60 % dispersion in oil), and the brown solution was stirred at 0 to -5 *C for 1 h and then bromodiphenylmetHane was added (1.1 eq), and then the reaction mixture was stirred overnight It was then quenched with water, diluted with ethyl acetate, washed with water and brine, dried over sodium sulfate and purified by column chromatography to yield 60 % of the desired product Step 4: To the above aldehyde (1.0 equiv) in CH3NO2 (0.075 M) was added ammonium acetate (9 equiv) and the resulting mixture was heated to reflux overnight The reaction mixture concentrated to a small volume and then diluted with EtOAc and washed with brine. The aqueous pHase was extracted with EtOAc. The combined organic extracts were washed with brine, dried over sodium sulfate and concentrated and purification by column chromatography to the desired nitrootefin (51% yield). Step 5: Zinc dust (20 equiv) was suspended in 5% aqueous HCI solution (8 M Zn/5% HCI). To this mixture was added HgCfe (0.28 equiv). The mixture was sHaken for 10 min, the aqueous pHase was decanted and replaced with fresh 5% HCI, and again the mixture was sHaken for 5 min and the aqueous pHase was removed. The zinc-mercury amalgam thus generated was then added to a mixture of the nitroolefin (1.0 equiv) and cone. HCI (80 equiv) in THF (0.04 M nitrootefin/THF). The mixture was maintained at a gentle reflux for 1 h. The formation of product was followed by TLC analysis. The mixture was cooled to room temperature and the solids were removed by filtration through Celite. Cone. NH.OH was added to the solution pHase and the mixture was concentrated on the rotary evaporator. The residue was dissolved in CH2CI2 and cone. NH4OH. The aqueous pHase was extracted with CH2CJ2, and the organic pHase was washed with brine, dried over sodium suffate, and concentrated to yield the desired crude amine(100%) tHat was used in the next step without purification. Step 7: To the amine form above (1.0 equiv) and sat. NaHCCb (0.14 M) in CH2CI2 (0.07 M) was added a-toluenesuffonyi chloride (1.0 equiv). After 1 h the mixture was poured into saturated sodium bicarbonate and extracted with CH2CI2. The combined organic pHase was washed with brine, dried over sodium suffate and purified by column chromatography (gradient edition using 10% EtOAo-hexanes -) 20% EtOAc-hexanes) to afford 40% of the desired sulfonamide. Step 8:The sulfonamide from above was dissolved in DMF (0.5 M) under nitrogen atmosphere, cooled to 0°C, treated with sodium hydride (1.05 eq of a 60 oil dipersion), stirred for 15 minutes to ensure anion generation, treated with t- butyldimethsityl chloride (1.2 eq) and then stirred for twp hours at 0°C at which time TLC analysis indicated the reaction was complete. The reaction was worked up by partitioning between 1/2 saturated ammonium chloride solution and ethyl acetate, extraction of the aqueous layers with ethyl acetate(2X), washing combined organic layers with brine (1X), drying over magnesium suffate and concentrating to yield quantitative crude yield of the desired protected sulfonamide. Step 9: To DMF (~1 ml) was added phosporous oxychloride (1.2 eq), these reagents were stirred for 10 minutes and then a solution of the indole(1eq) from above in DMF (0.8 M) was added. The resulting red reaction mixture is stirred for 4 hours, diluted with water and then the pH was adjusted to 8 (total volume of aqueous added about 3/4 of DMF added initially) and then the reaction was refluxed for 2 hours and finally cooled, extracted with didorometHane, aqueous layer extracted with dichlorometHane (2X), combined organic layers washed with brine (1X), dried over magnesium suffate and concentrate to yield 75% of a crude aldehyde tHat was used without further purification. Step 10: To the aldehyde from above (1 eq) in THF (1.2 M) was added 4- aminomethyl-benzoic acid methyl ester (1.2 eq), sodium triacetoxyborohydride (1.5 eq) and acetic acid (glacial, 1.5 eq). The reaction was stirred overnight and then worked up by the addition of saturated sodium bicarbonate and ethyl acetate, the layers were separated, the aqueous layer extracted with dichJorometHane (2X), combined organic layers washed with brine (1X), dried over magnesium sutfate and concentrated and purified via chromatography to yield 37% of the desired product Step 11: The resulting ester was hydrolyzed by stirring with 1N NaOH (5 equiv) in THF (0.07 M) and enough MeOH to produce a dear solution. The reaction was monitored by TLC (10% MeOH-CH- for the disappearance of starting material. The mixture was stirred at room temperature for 72 hours.. The mixture was concentrated, diluted with HaO, and acidified to pH 5 using 1 M HCI. The aqueous pHase was extracted with EtOAc and the organic pHase was washed with brine, dried over sodium sulfate, and concentrated to afford the desired product in 83% yield. HRMS calc for [C39H36CIN3O4S -H] 676.20423 found 676.20397. Example 135:4--1-)enzhydryl-2-2-Denzyteurfonyl)arnlno]-rthyl}-5- chloro-1H-lndo4-3yl)ethyfJsulfonyf}benzolc acid Step 1:2-5(Mc)ro-1H-indol-2-yl)etHanol (leq) was added to a solution (under Nz) containing fe/f-ButykJipheriylchlorosilane (1.2eq), imidazole (2.5eq). and DMF (1.8M). The reaction was stirred overnight Quenched with NaHCO, m and extracted with a EtsO/EtOAc mixture. The organic layer was washed with water and brine and dried over sodium sulfate. Purified with silica gel column and 1:4 Hexane/CHsCfe as eluent. Obtained 2-{[tert4)utyl(diphenyl)sflyl]oxy)ethyl)-&-lon)1H-indole (yellow oil) in 98% yield. Step 2: Methyl 4-{(2-oxoethyl)sutfanyl]benzoate (3.7eq) was added to a solution containing 2-[{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1H-indole (1eq), TFA (3eq), and 1,2-dichloroetHane (0.1M) at 0°C under N2. Then Et3SiH (12eq) was added and the reaction was allowed to return to room temperature and stirred overnight. Quenched reaction with NaHCO3(aq) and extracted with EtOAc and washed with brine and dried over sodium sulfate. Purified with silica gel column and 1:5 EtOAc/Hexane as eluent Obtained methyl 4-({2-[2-(2-{Itert- butyl(diphenyl)sily)]oxy}ethyl)-5-chloro-1 H-indol-3-yl]ethyl}sulfanyl)benzoate (yellow solid) in 79% yield. Step 3: Methyl 4-({2-{2-{2-[{tert-butyl(diphenyl)silyl]oxy}ethy1)-5-chloro-1H- indol-3-yl]ethyl}sulfanyl)benzoate (1eq) was added to a suspension of NaH (1.1eq) in DMF (0.37M) at 0°C under N2. After 30 minutes PrfcCHBr (1.8eq) was added and the reaction was wanned to room temperature. After 3 hours the reaction was quenched with NH4CI(aq)- and extracted with EtOAc/Et2O mix and washed with water and brine and dried over sodium suHate. Purified with silica gel column and 1:5 EtOAc/Hexane. Obtained methyl 3-[-({2-l1-benzhydryl-2-2-{Itert-butyl(drpheny0silyl]oxy}ethyl)-5- c-loro-1H-indol-3-yl]ethyl}sulfanyl)phenyl]benzoate (yeftow gum) in 65% yield. Step 4: NMO (4eq) was added to a solution/suspension containing methyl 3- [4H{2-14)erizhydryl-2-[2--tert-butyl(ctiphenyl]sHy-- yl]ethyl}sulfanyl]pheriyl]benzoate (1eq), ACN (0.1M), and molecular sieves (1g/mmole of benzoate) under N2. After 10 minutes TPAP (0.12eq) was added and the mixture was heated to 40°C. After 1.5 hours the reaction was cooled and filtered and the filtrate was collected. Purified with silica gel column and 1:5 EtOAc/Hexane. Obtained methyl 3-{4-({2-{1-benzhydryl-2-(2-{[tert-butyl(diphenyI)silyIloxy}ethyl)-5- chloro-1H-indol-3-yl]ethyJ}suffony»)phenyiP)enzoate (white solid) in 71% yield. Step 5: Tetrabutylammonhjm fluoride (1M in THF) (1.2eq) was added to a solution of methyl 3-{4-({2-{1-benzhydry1-2-{2-atert-butyl(dipnenyl)silyI]oxy)ethyl)5- chloro-1H-indol-3-ynethyl}sulfony0phenynbenzoate (1eq) and THF (0.1 M) at 0°C under N2. Warmed reaction to room temperature and after 1 hour quenched with NhUCW Extracted with EtOAc and washed with brine and dried over sodium suHate. Purified with silica gel column and 1:9 EtOAc/CHaCfe. Obtained methyl 3-[4- ({2-{1-benzhydryt-5-hloro-2-(2-hydroxyethyl)-1H-indol-3- yl]ethyl}sulfonyl]phenyr]benzoate (white solid) in 86% yield. Step 6: CH3SO2Cl (2eq) and Et,N (2.5eq) were added to a solution of methyl 3-{4-({2-{1-benzhydryl-5-chloro-2-(2-riydroxyethyl)-1H-4ndol-3- yl]ethyl}sulfonyl)phenyrjoenzoate (1eq) in CH2CI2 (0.02M) at 0°C under N2. After 1 hour the reaction was warmed to room temperature. After an additional hour water was added and extracted with CH2CI2 and washed with brine and dried over sodium sulfate. Removed solvent to obtain methyl 3-(4-{[2-(1-benzhydryl-5-chloro-2-{2- [(methylsulfonyl)oxylethyl}-1 H-indol-3-y1)ethyf]sulfonyl}phenyl)benzoate (light-yellow solid) in 99% yield. Step 7: Methyl 3-(4-{[2-(1-benzhydryl-5-chloro-2-{2- [(methylsulfonyl)oxy]ethyl}-1H-indol-3-yl)ethylsulfonyl}phenyl)benzoate(1eq), sodium azide (5eq), and DMF (0.05M) were placed together under N2 and heated to 60°C. After 1 hour the reaction was cooled and water was added. Extracted with EtOAc/Et2O mix and washed with water and brine and dried over sodium sulfate. Removed solvent to obtain methyl 3-{4-({2-I2-(2-a2idoethyl)-1-ben2hydryJ-5-chloro- 1KMndol-3-yl]ethyl}sulfonyl)phenyl]benzoate (light-yellow solid) in 99% yield. Step 8: Methyl 3-4K{2-2-azidoethyl)-1-benzhydryl-5-chloro-1HHndol-3- yl]ethyl}sulfdnyl)phenyl]benzoate (1eq), PPh, (2eq), and THF (0.1M) were placed together under N2 and stirred overnight Water (1mL/1mmole benzoate) was added and reaction was again stored overnight The solution was concentrated and purified with silica gel column and 3:1 EtOAc/Hexane followed by 5% MeOH in CHzCI* Obtained methyl 3-{4-({2-{2-(2-aminoethyl)-1-benzhydryl-5-loro-1H-indol-3- yl]ethyl}sulfonyl)pnenyl]benzoate (light-yellow sold) in 99% yield. Step 9: alpHa-Toluene sulfonyl chloride (2eq) was added to a mixture of methyl 3-4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]ethyf}sulfonyl)phenynbenzoate (1eq), CH2Cl2 (0.08M), water (1mL/1mL CH2CI2), and Na2CO3 (2.5eq). After 2 hours the organic layer was recovered and washed with brine and dried over sodium sulfate. Purified with silica gel preparatory plate and 3% MeOH in CH2Cl2. Obtained methyl 4-{[2-(1-benzhydry1-2-{2- [(benzylsulfonyl)amino]ethyr}-5-chloro-1H-indol-3-yl)ethl]sulfonyl}benzoate (off-white solid) in 94% yield. Step 10: Methyl 4-02-(1-ben2hydryl-2-{2-{(benzy1sutfonyl)amino}ethyl}-5- chloro-1H-indol-3-yl)ethyl)sulfonyI}benzoate (1eq). THF (0.1M), MeOH (1mL/1mL THF). and NaOH (1N) (11eq) were stirred together overnight. Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI and collected resulting precipitate by filtration. Obtained 4-{[2-(1- benzhydryl-2-{24(benzylsuffonyl)amino]ethyf}-5-chloro-1 H-indol-3- y1)ethyl]sulfoyl}benzoic acid (off-white- solid) in 92% yield. HRMS calc for [C39H35CIN2O6S2 -H] 725.15523 found 725.15437. Example 136:4-({2-[1-benzhydryl-5-chloro-2-2-{[(2-chlorobenzyl)- sulfonyl] amino}ethyl)-1H-indol-3-yl]othyl}8ulfonyl)ben2olc acid Step 1: (2-chlorobenzyl)sulfonyl chloride (3.4eq) was added to a mixture of methyl 3-4-{2-2-2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]ethyl}suffonyl)phenyl]benzoate (Example 135, Step 8,1eq), CH2CI2 (0.08M), water (1mL/1mL CH2CI2), and Na2CO3 (2.5eq). After 2 hours more (2-chlorobenzyl)sutfonyl chloride (3.4eq) was added. After an additional 1.5 hours the organic layer was recovered and washed with brine and dried over sodium sulfate. Purified with silica gel preparatory plate and 3% MeOH in CH2CI2. Obtained methyl 3-{4-({2-{1- benzhydryl-5-chloro-2-2-(2-chloroben2yl)sulfonyllarnino}ethyl)-1 H-indol-3- ylethyl]sulfonyl]phenyl]benzoate (orange gum) in 40% yield. Step 2: Methyl -4-({2-1-benzhydryl-5-chloro-2-(2-fl(2- chlorobenzyr)sutfonyrjamino}ethyl)-1 H-ind(-3-yflethyl]sulfonyf)phenyl]benzoate (1eq), THF (0.1M), MeOH (1mL/1mL THF), and NaOH (1N) (11eq) were stirred together overnight Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI and collected resulting precipitate by filtration. Obtained 4-({2-C1 -benzhydryl-5-chloro-2-(2-{I(2- chlorobenzyl)sulfonyl]amino)ethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoic acid (red- orange solid) in 80% yield. HRMS calc for [C39H34Cl2N2O- +H] 761.13081 found 761.13146. Example 137:4-e2-[1-benzhydryl-5-chloro-2-(2-{[(2,6- drfluorobenzyl) sulfonyfjamino}ethyl)- 1H-indol-3-yl]ethyl}sulfonyl)benzoic acid Step 1: (2,6-difiuorobenzyl)sulfonyl chloride (3.4eq) was added to a mixture of methyl 3-{4-({2-I2-(2-amlnoethyl)-1-benzhydryl-5-chloro-1H-endol-3- yl]ethyl}sulfonyl)phenyl]benzoate (Example 135, Step 8,1eq), CH2Cl2 (0.08M), water (1mL/1mL CH2Cl2), and Na2CO3 (2.5eq). After 2 hours the organic layer was recovered and washed with brine and dried over sodium sutfate. Purified with silica gel preparatory plate and 3% MeOH in a-feCfe. Obtained methyl 4-({2-{1-benzhydryl- 5-chloro-2-(2-{[(2,6-difluoroberizyl)sutfonyl]amino)ethyl)-1 H-indol-3- yl]ethyl}sulfonyl)benzoate (off-white solid) in 87% yield. Step 2: Methyl 4-({2-l1-benzhydryl-5-chloro-2-(2-{I(2,6- dffluorobenzyl)suffonyllamino}eth-1H-indol-3-yl]ethyl}sulfonyl)benzoate(1eq), THF (0.1M), MeOH (1mL/1mLTHF), and NaOH (1N) (11eq) were stirred together overnight. Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI and collected resulting precipitate by filtration. Obtained 4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2.6- difluobenzyl)benzyl)sutfonyl]amino}ethyl)-1l+4rKlol-3-yl}ethyf}sutfonyl)benzoic acid (white- yellow solid) in 96% yield. HRMS calc for [C39H33CIF2N2O- -H] 761.13638 found 761.13565. Example 138:4-((2-[1-benzhydry1-5-chloro-2-(2-{[(2- fluorobenzy1)sulfonyl] amino}ethyl)-1H-indol-3-qethyl}eulf6nyl)benzoic acid Step 1: (2-fluorobenzyl]sulfonyl chloride (3.4eq) was added to a mixture of methyl 3-4-{2-(2-minoethyl]-1-ben2hydryl-5-cnloro-1H-indol-3- yl]ethyl}sulfonyl)phenyl]benzoate (Example 135, Step 8,1eq), CH2Cl2 (0.08M), water (1mL/1mL CH2Cl2, and Na2CO3 (2.5eq). After 2 hours the organic layer was recovered and washed with brine and dried over sodium sulfate. Purified with silica gel preparatory plate and 3% MeOH in CH2Cl2. Obtained methyl 4-{{2-[1-benzhydryl- 5-chloro-2-(2-{[(2-fluorobenzyl)sulfonyl}amino}ethyl)-1 H-indol-3- yl]ethyl]sulfonyl]benzoate (off-white solid) in 82% yield. Step 2: Methyl 4-{{2-{1-ben2hydryl-5-chloro-2-(2-{I(2- fluorobenzyl)sulfonyl]amirK))ethyl-1H-in(k)l-3-yl)ethylsutf(xiyl)bercoate (1eq), THF (0.1M), MeOH (1mL/1mL THF), and NaOH (1N) (11eq) were stirred together overnight Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI and collected resulting precipitate by filtration. Obtained 4-{2-1-benzioc acid-5-chloro-2-(2-{[(2-fluorotenzyl)sulfonyl]amino}ethyl- 1H-indol-3-yl]ethyl}sulfonyl)benzoic acid (off-white solid) in 99% yield. HRMS calc for [CH34CIFN2O6S2 -H] 743.1458 found 743.14511. Example 139:4-(2-{1-Benzhydryl-5-chloro-2-p-{2-pyrrolidin-1-yl- ethanesulfonylamino)-ethyl]-1H-lndol-3-yl}-ethoxyl)benziic acid Step 1: The compound was prepared from the intermediate from Example 87 step 1 and pyrrolidine according to the procedure in Example 87 step 2 in 92 % yield without the column purification. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 92 % yield. HRMS calc for [C38H40CIN3O5S -H] 684.23044 found 684.23009. Example 140:4-({2-{1-benzhydryI-5-chloro-2-(2-{I(3,4-dichlorobenzyl) sulfonyl]amino)ethyl)1H-ndol-3-yl]]ethyf}sulfonyl)benzoic acid Step 1: (3,4-dichiorobenzyl]sulfonyt chloride (2.1 eq) was added to a mixture of methyl 3-[4-({2-2-2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol(-3- yl]ethyl]sulfonyl]phenyfJbenzoate (Example 135, Step 8,1eq), CH2CI2 (0.08M), water (1mL/1mL CH2O2), and Na2CO3 (2.5eq). After 1 hours the organic layer was recovered and washed with brine and dried over sodium suffate. Purified with silica gel preparatory plate and 3% MeOH in CH2Cl2. Obtained methyl 4-({2-{1-benzhydryl- 5-chloro(2-(2-{[(3,4-dichlorobenzyr)-- yl]ethyl]surfonyl]benzoate (white solid) in 87% yield. Step 2: Methyl 4-{2-{1-benzhydryl-5-chloro-2-(2-{[(3r4- dichlorobenzyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate(1eq), THF (0.1M), MeOH (1ml/1mL THF), and NaOH (1N) (11eq) were stirred together overnight Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI and collected resulting precipitate by filtration. Obtained 4-({2-f1-benzhydryl-5-chloro-2-(2-fl(3I4- dichkxoberizy1)su!fony0amir)o}eto-- acid (white- yellow solid) in 93% yield. HRMS calc for [C38H33Cl3N2O6S2 -H] 793.07728 found 793.07629 Example 141:4-({2-{1-benrhydryl-5-chJoro-2-(2-{t(2,6- dimethylbenzyl)sulfbnyt] amino)ethyl) 1H-indol-3-yyl]ethyl}sulfonyl)benzoic acid Step 1: (2,6-methylbenzyl)sulfonyl chloride (3.0 eq, example 52, step 1) was added to a mixture of methyl 3-{4-({2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H- indol-3-yl]ethyl}sulfonyl)phenyl]benzoate (Example 135, Step 8,1eq), CH2CI2 (0.08M), water (1mL/1mL CH2Cl2), and Na2CO3 (2.5eq). After 2 hours the organic layer was recovered and washed with brine and dried over sodium sulfate. Purified with silica gel preparatory plate and 3% MeOH in CH2Cl2. Obtained methyl 4-({2-{1- ben2ydryl-5(-k)ro-2-[2-{[(2,6-imethylbenzyl)sulfonyl]amino}ethyl)-1H-indol-3- yl]ethyl}sulfonyl)benzoate (fight-brown solid) in 81% yield. Step 2: Methyl 4-({2-{1-benzhydryl-5-chloro-2-(2-{[(2l6- dimethylbenzyl]sulfonyl] amino}ethyt)-1H-indol-3-yl}ethyt}suffonyl)ben2oate (1eq), THF (0.1M), MeOH (1mL71mL THF). and NaOH (1N) (11eq) were stirred together overnight. Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N Ha and collected resulting precipitate by filtration. Obtained 4-({2-{1-benzhydryl-5-chloro-2-(2-{I(2)6- dimethylbenzyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyr}sulfbnyl)benzoic acid (white solid) in 99% yield. HRMS calc for [C41H39CIN2O6S2 + H] 753.18653 found 753.18597. Method J provides an alternative reaction scheme to a subset of the compounds contained in this document A suitably substituted aniline is Halogenated using ICI. l2, or Br2 and then the amine is protected as a carbamate, using for example triethylamine and a chtorofbrmate. This aryt Halide is coupled to a suitably functionalized alkyne under the reaction of Pd and copper catalysis in the presence of a base such as triethylamine. This resulting product could be cyclized using Pd catalysis in the presence of allyl chloride and a substituted oxirane. The indde nitrogen may then be alkylated by treatment with a strong base such as sodium bis(trimethyteilyl)amidep n-BuU, sodium hydride or potassium hydride in a solvent such as DMF, DMSO or THF followed by exposure to the appropriate Halide. The allyl indote could then be treated with 9-BBN and then a palladium catalyst followed by an aryl or vinyl iodide to effect a Suzuki coupling reaction. The resulting intermediate could be deprotected usiong a hydrazine or an alkyl amine to yield the primary amine. This amine could then be treated with the requisite sulfonyl chloride under bipHasic conditions, aqueous sodium bicarbonate/dichlorometHane, or in organic solvent with the addition of a hindered organic amine base. The final hydrolysis was accomplished under basic conditions with sodium hydroxide in water and metHanol and THF at room temperature or at elevated temperature. Alternatively it may be cleaved by treatment with sodium thiomethoxkJe in a solvent such as THF or DMF at elevated temperatures (50 'C -100 'C). Method K provides an alternative method to prepare compounds of this invention. A suitably substituted aniline is Halogenated using ICI. l2. or Br2 and then the amine is protected as a carbamate or amide .using for example trifluoroacetic anhydride triethyamine and dimethylamino pyridine. This intermediate is then reacted with a suitably functionalized alkyne under palladium and copper catalysis in the presence of a base. The resulting aryl alkyne is cyclized to the indole by heating with an amine such as piperidine. Standard Mitsunobu reaction conditions, a phosphine, an azodicarboxylate and phtHalamide are used to generate the protected amine. The indote may be alkylated at the C3 position (the indote 3-position carbon atom) with aldehydes or the corresponding acetate in the presence of a Lewis or Bronsted acid, such as boron triflouride etherate or trifluoroacetic add. The indole nitrogen may then be alkyiated by treatment with a strong base such as sodium bis(trimethylsilyl)amide, n-BuLi, sodium hydride or potassium hydride in a solvent such as DMF, DMSO or THF followed by exposure to the appropriate Halide. The resulting intermediate could be deprotected usiong a hydrazine or an alkyl amine to yield the primary amine. This amine could then be treated with the requisite sutfonyl chloride under DipHasic conditions, aqueous sodium bicarbonate/dichlorometHane, or in organic solvent with the addition of a hindered organic amine base. The final hydrolysis was accomplished under basic conditions with sodium hydroxide in water and metHanol and THF at room temperature or at elevated temperature. Alternatively it may be cleaved by treatment with sodium thiomethoxide in a solvent such as THF or DMF at elevated temperatures (50'C -100 *C). Method L provides another alternative method to prepare compounds of this invention. A suitably substituted Halo aniline, see methods J and K, and a symmetric alkynol or a monoprotected alkynol, for example THP protection, are reacted in the presence of a base, copper and palladium catalysis, followed by deprotection under acidic conditions if a monoprotected substrate is used yielded the symmetrical indole did. The diol is desymmetrized by treatment with carbonyl diimidazoJe in a suitable solvent and then the primary alcohol was substituted under standard Mitsunobu conditions, a phosphine, an azodicarboxylate and an alcohol were used to generated the desired ether. The carbamate could be opened up by reaction with sodium azide to yield the alkyl azide. The indole nitrogen may then be alkylated by treatment with a strong base such as sodium bis(trimethylsilyl)amide, n-BuLi, sodium hydride or potassium hydride in a solvent such as DMF. DMSO or THF followed by exposure to the appropriate Halide. Treatment with triphenyl phosphine in wet THf delivered the desired alkyl amine. This amine could then be treated with the requisite sulfonyl chloride under bipHasic conditions, aqueous sodium bicarbonate/dichlorometHane, or in organic solvent with the addition of a hindered organic amine base. The final hydrolysis was accomplished under basic conditions with sodium hydroxide in water and metHanoi and THF at room temperature or at elevated temperature. Alternatively it may be cleaved by treatment with sodium thiomethoxide in a solvent such as THF or DMF at elevated temperatures (50 'C -100 *C). Method M provides a further strategy to furnish compounds of this invention. A suitably substituted aniline is Halogenated using ICI, l2, or Br2 and then the amine can be alkylated using an organic base and a Halide. The thus formed alkyl amine is then reacted under palladium catalyzed conditions in the presence of a chloride source a base and with or without a phsophine and the requisite alkyne to yield the indole. When the Z in the alkyne is NHSO2CH2)n2X1R1 the synthesis is finished by hydrolysis under basic conditions with sodium hydroxide in water and methanol and THF at room temperature or at elevated temperature. Alternatively ft may be cleaved by treatment with sodium thiomethoxide in a solvent such as THF or DMF at elevated temperatures (50 *C -100 *C). When Z=NH2 The resulting indole can then be treated with the requisite suffonyf chloride under DipHasic conditions, aqueous sodium bicarbonate/dichlorometHane, or in organic solvent with the addition of a hindered organic amine base. The final hydrolysis was accomplished under basic conditions with sodium hydroxide in water and metHanol and THF at room temperature or at elevated temperature. Alternatively it may be cleaved by treatment with sodium thiomethoxide in a solvent such as THF or DMF at elevated temperatures (50'C-100 *C). When Z=OH The resulting alcohol could be converted to a Halide or mesylate, for example using metHane sulfonyi chloride and an organic base, which could then be displaced by sodium azide in OMF.The resulting alkyl azide could be reduced under the action of triphenyl phosphine and wet THF. The amine could be sulfonylated by the action of a sulfonyi chloride under either bipHasic Sncott and Baumman conditions, Aq. Bicarbonate and dichlorometHane, or under anhydrous conditions consisting of dichlorometHane and an organic base such as Hunigs base. The resulting intermediate was hydrolyzed using a base, NaOH, KOH, LiOH and a mixture of solvents including an alcoholic solvent, water and tetrahydrofuran. Method N provides a further strategy to furnish a subset of the compounds of this invention. The C3 functionalized-2-formyl indole (See method A) was reacted under Wittig, or other organometalfic conditions, to generate an alkeneoate ester. This ester could be converted to the acid by treatment with Pd and the resulting unsaturated acid was reduced via hydrogenation. The alkyl add was activated by conversion to the acid chloride, under the action of oxalyf chloride, or the acid flouride, via cyanuric flouride, and then treated with a suitable borohydride reducing agent to generate the alcohol. The alcohol was converted to the bromide using triphenyl phosphine and carbontetrabromide and then displaced by the anion of the sulfonmide, generated by treating the primary sulfonamide with a strong base, such as NaH, n-BuLi etc, to yield the desired secondary sulfonamide. The resulting ester intermediate was hydroryzed using a base, NaOH, KOH, UOH and a mixture of solvents including an alcoholic solvent, water and tetrahydrofuran. Example 142:4-p-(14)en2hydryl-2-{H(benzyisulfonyl)amino]propyI)-6- chloro-1H-lndol-3-yl)ethoxy]benzolc acid Step 1: 5.0g of 4-[2-(1-Benzhydry(-2-formyl-1H-ndol-3-yl)-ethoxy])benzoic acid methyl ester, Step 4,Example 1, (.0092M, 1.0eq.) and 5.0g of allyl(triphenylphosphoranylidene) acetate (.0139M, 1.5eq.) were dissolved in 250mL of tetrahydrofuran at room temperature. The pale yellow solution was stirred for one hour. TLC indicated a new spot at DRf of +0.5 in 1:1 hexanes/ ethyl acetate and no remaining starting indole. The reaction was poured into 500mL of ethyl acetate and washed with water (2X125mL) and brine (2X125mL). The organic layer was dried over magnesium sulfate and filtered. The filtrate was evaporated to a yellow oil which was dissolved in 50ml 1:1 hexanes/ ethyl acetate and filtered through a plug of silica gel to remove baseline material. This left 5.23g of 4-{2-{2-(2-Allyloxycarbonyl-vinyl)-1- benzhydryl-5-chiorc)-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester as a yellow oil (91% yield). Step 2: 6.12g of 4-{2-p-(2-Allyloxycart)onyhnnyl)-1-benzhydryl-5-chtoro-1H- indol-3-yl]-ethoxy}-benzoic add methyl ester (0.098M, leq.) and 1.12g of tetrakis(triphenylphosphine) palladium (0) (.001M, 0.1eq.) were added to 75mL of THF. To the reaction 8.60ml of morpholine (0.098M, 1eq.) was added drop-wise over 20 min. After addition was complete the reaction was stirred at room temperature for 4 hours. The reaction was poured into 250mL of ethyl acetate and the organic solution was extracted with 1N NaOH (2X75mL). The aqueous layers were combined and acidified with 1N HCI, the acidic solution was extracted with ethyl acetate (3X75mL). The organic layers were combined and washed with brine (1X50mL), dried over magnesium sulfate, filtered and evaporated to yield 4-{2-{1-Benzhydryl-2- (2(arboxy-myl)-5(hloro-1H-indol-3-yl]-ethoxyH)enzoic add methyl ester as a yellow oil (5.40g, 97% yield). Step 3: 400mg of 4--1-Benzhydryl-2-2-carboxy-vinyl)-5-chloro-1H-indol-3- yl]-ethoxy}-benzoic acid methyl ester ( .0007M, 1eq.) was dissolved in 15mL of metHanol. To the solution, 80mg of 5% platinum on activated carbon was added as a slurry in 5mL of metHanol. The black suspension was placed under a hydrogen atmosphere via a balloon and stirred for 24 hrs. at room temperature. The hydrogen was evacuated and another 80mg of 5% platinum on activated carbon in 5mL of metHanol was added and the reaction was again placed under a hydrogen atmosphere via a balloon and stirred for another 24 hrs. at room temperature. The reaction was monitored via NMR and at this point complete conversion was indicated. The reaction was filtered through CeIHe and the filtrate was evaporated to give 4-{2-[1-Benzhydryl-2-2-carboxy-ethyl-5-chloro-1H-indol-3-yl]-ethoxy}-benzaoic add methyl ester as a yetow-green solid (320mg, 79% yield). Step 4: 100mg of 4-2H1-Bennzhydryl-2-[2-carboxy-ethyl)-5-chloro-1H-indol-3- yl]-ethoxy}-benzoic add methyl ester (.0002M, 1eq.) was dissolved in 1.0ml of anhydrous methylene chloride. To the solution 33.5mg of oxalyl chloride (.0003M, 1.5eq.) was added and the reaction stirred for one hour at room temperature. The reaction was then evaporated to dryness and the residue dissolved in LOrnL of anhydrous ethyl ether to which .027mL of TMEDA was added. To this solution 0.35 mL of zinc borohydride solution in ether prepared by the literature method( Tet Lett. Vol. 22, pg.4723, 1981) was added. The reaction was stirred for 15 min. at room temperature and quenched with 1.0mL of water. The reaction was diluted with 10mL of ethyl ether and the water layer separated, the organic layer was dried over magnesium sutfate, filtered and evaporated to a clear oil. The oil was chromatographed with ethyl acetate/ hexanes (1:9) to result in isolation of 4-{2-{1- Bennzhydry-5-chloro-2-(3-hydroxypropyl)-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester as a white foam (81 mg, 83% yield). Step 6: 104.0mg of 4-241-Ben2hydryl-5-chloro-2-{3-hydroxy-pfopyl)-1H- indol-3-yl}-ethoxy}-benzoic acid methyl ester (.0002M, 1.0eq.) was dissolved in 2.0mL of anhydrous methytene chloride. To the solution 116.0mg of polystyrene bound triphenylphosphine was added ( 1.61mmol/g, .0002M, 1.0eq.) followed by 125.0mg of carbon tetrabromide (.0004M, 2eq.). The suspension was stirred for 2hrs at room temperature at which point the reaction was filtered and the filtrate evaporated to an orange oil. The oil was purified via column chromatography with ethyl acetate/ hexanes (2:98) to give 100mg (88%) of 4-(2-{1-benzhydryl-2-(3-bromo- propyf)5H-chloro-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester title as a yelow foam. Step 6: 33.3mg of a-toluene sulfonamide (.0002M, 1.2eq.) was dissolved in 0.5mL of DMF and added to a slurry of 8.0mg of 60% sodium hydride ( .0002M, 1.2eq.) in 0.5mL of DMF. The reaction was stirred for 30 min. at which point 100 mg of 4K2-[1-Benzhydrye-3-Drorno-propyl)-5-chloro-1H-indol-3-yl]ethoxy}-benzoic acid methyl ester (.0002M, 1.0eq.) in 0.6mL of DMF was added and the solution was stirred for an additional 1 hour. The reaction was quenched with water and diluted with 10mL of ethyl acetate. The organic layer was washed with water(2X5mL) and brine (2X5mL), dried over magnesium sutfate and evaporated to a yellow oil. The residue was purified via column chromatography (ethyl acetate/hexanes 5:95) to give 20mg (17%) of 4--1-Benzhydryl-5(hloro-2-3-phenylmetHanesulfonylamino- propyl)-1H-indol-3-yl]-ethoxy}-benzoicacid methyl ester as a clear oil. Step 7: 20.0mg of indole from Example 6 (.00002M, 1eq.) was hydrolyzed as in Example 1 Step 8 to yield the title compound (13.0mg, 88 % yield) m/z (M-1) 691. The appropriately substituted Halo amine is reacted with a suitable Halide and a tertiary amine base to yield an N-alkylated substrate for a Shonigishiru coupling (with an alkynoJ in the presence of Pd" and a suitable base). This arylalkynol is cyclized to the indole under the action of a copper Haiide and heat The free alcohol was protected with a silyl protecting group by reaction with a silyl chloride in the presence of a base such as imidazole. This indole was next C3 acylated by reaction with a suitable acid chloride and the resulting compound reduced with most reducing agents but preferably borane or a borane complex The primary alcohol was then oxidized to an aldehyde by any number of oxlidizing agents, including oxalyl chloride/DMSO (swem conditions) or TPAP/NMO. This aldehyde was subjected to reductive amination conditions, which include a borohydride reducing agent and in some cases a protice acid, and a primary or secondary amine. The silyl ether was then deprotected with a flouride source including CsF, TBAF, HF etc. This free alcohol was converted into a leaving group, Halide with CBr4 and a phosphine, or a sulfbnate ester with metHane sulfbnyi chloride and a tertiary amine. The activated alcohol is reacted with sodium azide in either DMF or DMSO to yield the desired azide which in turn was reduced under Staudinger conditions, phosphine and THF/H2O, or via hydrogenation using hydrogen and a suitable catalyst The amine could be sutfonylated by the action of a sulfonyl chloride under either DipHasic Shcott and Baumman conditions, Aq. Bicarbonate and dichlorometHane, or under anhydrous conditions consisting of dichlorometHane and an organic base such as Hunigs base. The resulting intermediate was hydroryzed using a base, NaOH, KOH, LiOH and a mixture of solvents including an alcoholic solvent, water and tetrahydrofuran. The following Examples 143-151 were synthesized with Method N. Example 143: 4-{[2-(1-benzhydryl-2-{2-I(benzy1surfonyl)amino]ethyl}-5- chloro-1H-indol-3- yl)ethyl]amino}benzolc acid Step 1: To a solution of 4-chk)ro-2-iodoaniline (16.5 g, 65.1 mmol) in DMF (250 mL) at rt were added D-bromodiphenylmetHane (21.5g, 84.6 mmol) and lPr2NEt (23 mL, 130 mmol) and the reaction mixture was heated at 45 *C overnight After the volatile was removed under reduced pressure, the residue was dissolved in EtOAc, washed with water (3x) and brine and dried over MgSO4. Purification on SiO2 column chromoatography (hexanes to 5% EtOAc/hexanes) gave the desired Benzhydryl-(4(hloro-2-kxlo-phenyl)-amine (26.1 g, 97% yield) as a yellowish solid. Step 2: A mixture of berizhydryl-(4-chioro-2-iodo-phenyl)-amine (26.1g, 62.2 mmol), PdCl2CPPh3)2 (1.90 g, 2.67 mmol). Cul (1.2 g. 6.2 mmol), 3-butyn-1-ol, and Et3N (120 mL) was stirred at 45 *C for 20 hours. The reaction mixture was filtered through cefite and rinsed with EtOAc. The filtrate was concentrated, redissolved in EtQAc, washed with water (3x) and brine, and dried over MgSO4. The crude 4-{2- (Beri2hydfyl-amino)-5chloro-phenyl]-but-3-yn-1-ol (25.5 g) was used in the next step directly without further purification. Step 3: A solution of the crude 4-2-[benzhydry(-mirK)-5K-loro-phenyl]-but- 3-vn-1-ol (25.5 g) and Cul (2.7 g, 14.1 mmd) in DMF (200mL) was heated at 125 *C for 24 hours. The reaction mixture was filtered through celite and rinsed with EtOAc. The filtrate was concentrated, redissolved in EtOAc, washed with water (3x) and brine, and dried over MgSO4. Silica gel column chromatography (30% EtOAc/hexanes) yielded the desired 2-(1-Benzhydryl-5-chlon)1HHndol-2-yl)etHanol as a yellow solid (14.5 g, 73% over 2 steps). Step 4: To a solution of 2-(1-benzhydryl-5-chloro-1H-indol-2-y1)-etHanol (15.3 g, 42.3 mmol) in CH2CI2 (190 mL) at 0 *C were added imidazole (3.72g, 55.0 mmol) and TBDPSCI (13.2 mL, 50.8 mmot). After stirring at the same temperature for 1.5 hours, the reaction mixture was washed with cold water (3x) and brine, and dried over MgSO4. The crude silyl ether was used in the next step directly without further purification. Step 5: To a solution of the crude silyl ether in EfeO (200 mL) at 0 °C was added oxalyl chloride (4.84 mL, 55.5 mmol) dropwise. The reaction mixture was allowed to warm to rt and stirring continued for 4 hours before Et3N (35 mL) and MeOH (10 mL) were added. The mixture was washed with water, brine, and dried over MgSO4. The crude keto ester was used directly in the next step. Step 6: To the keto ester in THF (300 mL) was added BH8.MeaS (10 M, 36 mL) dropwise at rt and the reaction mixture was refluxed overnight. The mixture was cooled at 0 *C before NaOH (30%, 150 mL) was added and stirring continued for 30 min. THF was removed under reduced pressure and the reaction mixture was extracted with EtOAc, washed with water, brine, and dried over MgSO(. Purification on column chromatography (15 to 20% EtOAc/hexanes) yielded the desired product as a white solid (15.9 g, 24.7 mmol, 58% over 3 steps). Step 7: To a solution of oxalyl chloride (0.372 mL, 4.27 mmol) in CH2CI2 (10 mL) at -78 °C was added DMSO (0.661 mL, 9.31 mmol) dropwise. The reaction mixture was stirred at the same temperature for 5 min before a solution of 2- {1-benzhydryl-tert-butyl-diphenyl-silanyloxy)-ethyl-5-chloro-1H-indol-3-yl}- etHanol (2.50 g, 3.88 mmol) in CH2Cl2 (8 mL) was introduced. After additional 40 min stirring, iPr2NEt (3.38 mL, 19.4 mmol) was added and the reaction was quenched with cold water (5 mL) and extracted with CH2CI2. The organic layer was dried over MgSO4 and evaporated. The crude {1-Benzhydryl-2-I2-{tert-buty-diphenyl- silanyloxy)-ethyl)5-chloro-1H-indol-3-yl)-acetaldehyde was used directly in the next step. Step 6: To a solution of the crude aldehyde (3.88 mmol) in 1,2- dichloroetHane (39 mL) at 0 *C were added methyl 4-aminobenzoate (645 mg, 4.27 mmol). acetic acid (1.33 mL), and NaBH(OAc)3. The reaction mixture was allowed to warm to rt overnight and quenched with cold NaHCO3. An extractive workup furnished the desired 4-(2-{1-Benzhydryl-2-[2-(tert-butyl-dipnenyl-silanyloxy)-ethyl]-5- chloro-1H-indol-3-yl}-ethylamino)-benzoic acid methyl ester which was used directly in the next step without further purification. Step 9: To 4-(2-{1-benzhydryl-2-{2-{tert-buty)-diphenyl-silanyloxy)- ethyl]-5-chloro-11H-indol-3-yl)-ethylamino)-benzoic acid methyl ester (3.88 mmol) in THF (25 mL) at 0 "C was acided a mixture of H0Ac:1M TBAF (in THF) (2.3 mL5.8 mL) and the reaction mixture was allowed to stir at rt for 18h. Extractive workup followed by trituration with 5%EtOAc/hex gave the desired 4-{2-[1-Benzhydryl-5- chloro-2-{2-hydroxy-ethyl)-1H-indol-3-yl]-etriytamino}-t)enzoic acid methyl ester with slight impurity as an off-white solid (92%, over 3 steps). Step 10: To a solution of 4-{2-{1-benzhydryl-5-chloro-2-(2-hydroxy- ethye)-1H-(ndol-3-yl]-etriytami-ben2olc acid methyl ester (1.64 g, 3.04 mmol) in CH2CI2 at 0 °C were acided Et,N (0.636 mL, 4.56 mmol) and MsCI (0.282mL, 3.64 mmol). After stirring at the same temperature for 35 min, the reaction mixture was quenched with cold water. An extractive workup revealed the crude mesylate as an off-white solid (1.70 g, 90%). Step 11: A solution of the crude mesylate (1.70 g, 2.75 mmol) and NaN3 (89 mg, 13.8 mmol) in DMF (14 mL) was stirred at 80 *C for 6h. The reaction mixture was diluted with EtOAc and subjected to an aqueous workup followed by flash column chromatography to yield the desired 4-{2-[2-(2-Azido-ethyr)-1- benzhydryl-5(-lorc)-imrKtol-3-yl]-ethy(amino}-benzoic acid methyl ester (813 mg, 52% yield). Step 12: To 4-{2-{2-(2-a2ido-ethyl)-1-benzhydryl-5-chloro-1H-indol-3- yf)-ethylamino}-benzoic acid methyl ester (400 mg, 0.709 mmol) in THF (4 mL) at 0 C was acided ph3p (223 mg, 0.851 mmol) in portions. The reaction mixture was stirred at rt for 11h and 35 *C for 4h before water (50 uL) was acided and stirring continued overnight. The reaction mixture was diluted with EtOAc, dried with MgSO4 and purified by flash column chromatography (EtOAc to 20%MeOH/EtOAc with 1% Et,N) to give the desired 4-{2-[2-(2-Amino)-ethyl-1-benzhydryl-5-chloro-1H-indol-3-yl]- ethylamino}-benzoic acid methyl ester (201 mg, 53 %) as a solid. Step 13: The intermediate from step 8 was treated with a- toluenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 72% yield. Step 14: The ester intermediate was hydrolyzed according to Step 8 Example 1, to afford the title acid in 87 % yield. HRMS cafe for [CMHMCIN3O4S+H] 678.21879 found 678.2178. Example 144: 4-({2-1-benzhydryl-5-chloro-2-(2-{[(2-chloro-6- methytphonyl)sullfnyl]amino}ethyl)1H-ndol-3-Qethyl}amino)b»nzoieacid Step 1: The intermediate from example 142 step 12 was treated with 2-chloro-6-methyl-benzenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 85% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1, to afford the title acid in 96 % yield. HRMS calc for [C3H35Cl2N3C-S+H1 712.17981 found 712.17895. Example 145: 4-({2-f1-benzhydryl-5-chloro-2-(2-(K2- methoxyphenyl)sulfdnyl]amino)ethyl)-1H- lndol-3-yl]ethyf}arnirto)benzoic acid Step 1: The intermediate from example 142 step 12 was treated with 2-methoxy-benzenesulfbnyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 85% yield. .Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1. to afford the title acid in 92 % yield. HRMS calc for [C39H35CIN3O5S+H] 694.2137 found 694.21311. Example 146:4-({2-{1-ben2hydryl-6-chloro.2-(2-a(2- chloropfienyl)sulfonyl]arnino}ethyl)-1H- lndol-yl]ethyl)amlno)benzolc acid Step 1: The intermediate from example 142 step 12 was treated with 2- chloro-benzenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 21% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1, to afford the title acid in 94 % yield. HRMS calc for [C38H33CI2N3O4S+H] 698.16416 found 698.16365. Example 147:4HP-14)enzhydryl-2-4(benzylsulfonyl)ainino]ethyn]6- chloro-1H-indol-3- y1)ethyfj(methyl)aniino]benzoic acid Step 1: Crude {1-Benzhydryl-2-{2-(tert-butyf-diphenyl-silanyk)xy)- ethyl-5H*k)ro-1H-indol-3-yl}-acetalclehyde from step 7, example 142 was treated with 4-Methylamino-benzoic acid methyl ester according to the procedure in Example 142 step 8 to yield the desired 4-{(2-{1-Benzhydryl-2-{2-{tert-butyl-diphenyl- sila-yloxy)-thyll-5-chloro-1H-indol-3-yI}-ethyl)-rnethyl-amino}-benzoic acid methyl ester in 73% yield Step 2: The title compound was prepared according to the procedure described for Example 142 step 9. The crude 4-({2-{1-Ben2hydryl-5-chloro-2-(2- hydroxy-thyl)-1H-indol-3-y1]-thyl}-methyl-mino)-benzoJc acid methyl ester was used in the next step directly without further purification. Step 3-6: 4-{2-2-Azido-thyl)1-ben2hydry-5-chloro-1H-indol-3-yl]- ethyl}-methyl-amino)-benzcoic acid methyl ester was prepared according to the procedure described for example 142 steps 10-12 in 61% (3 steps). Step 7: A solution of 4-({2-{2-{2-azido-ethyl)-1-benzhydryl-5-chloro-1H- indol-3-yrj-ethyl}-methyl-amino)-benzoic acid methyl ester (410 mg, 0.709 mmol) and 10% Pd/C (155mg) in MeOHrCHaCl2 (= 7 mL1 mL) was stirred under H2 atmosphere (1 aim) for 2h15 min. The reaction mixture was filtered through ceBte and rinsed with MeOH and CH2CI2. Flash column chromatography (CH2CI2 to 8% MeOH/CH2Cl2) of the residue gave the desired 4-{242-2-Amlno-ethyl)-1-enzhydryl-5-chloro-1H-indol. 3-yl]-ethyl}-methyl-amino)-benzoic acid methyl ester in 78% yield (305 mg). Step 8: The intermediate from step 7 was treated with a-toluenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 83% yield. Step 9: The ester intermediate was hydrolyzed according to Step 8 Example 1, to afford the title acid in 91 % yield. HRMS calc for [C39HMaN3O4S+H] 692.23444 found 692.23374: Example 148:4-|{2-{1-benzhydryl-6-chloro-2-(2-{[(3f4- dichlorobenzyl)sulfonyl]amlno)ethyl)- 1H-indol-3- yl]ethyf}(methyl)amino]benzolc acid Step 1: The intermediate from example 146 step 7 was treated with 3,4- dicMorophenylrnetHanesulfonyichloride according to the procedure in Example 87 step 2 to generate the desired product in 87% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1, to afford the title acid in 68 % yield. HRMS calc for [C40H36CUN3O4S+H] 760.15649 found 760.1573. Example 149:4-{{2-[H)enzhydryl-5-chloro-2-(2-{I(2(hloro-- methylphenyl)-sulfonyl]enino}ethyl)-1H-lndol-3-yl]athyl}(methyl)amino]ben2oic acid Step 1: The intermediate from example 146 step 7 was treated with 2-chloro- 6-methyl-benzenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 96% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1, to afford the title acid in 88 % yield. HRMS calc for [c40H37CI2N3C4S+H] 726.19546 found 726.19461. Example 160:4-[{2-(1-berahydryl-5-chloro-2-(2-a(2-chlorophenyl)- sulf6nyl]amino}ethyl]1H- Indol-3-qethyl(methyl)amlno]benzoic acid Step 1: The intermediate from example 146 step 7 was treated with 2- chlorobenzenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 96% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1, to afford the title acid in 84 % yield. HRMS calc for [C39H35Cl2N3O4S+H] 712.17981 found 712.17966. Example 151:4---[1-benzhydry1-5-chloro-2-(2-a(2Hnethoxyphenyl). surfonyf]amino}ethyl)-1H- lndol-3-yl]ethyl}(methyt)amino]benzolc acid Step 1: The intermediate from example 146 step 7 was treated with 2- methoxy-benzenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 95% yield. Step 2: The ester intermediate was hydrolyzed according to Stop 8 Example 1, to afford the title acid in 73 % yield. HRMS calc for [C4OH38CIN3O5S+H] 708.22935 found 708.2286. Example 152: 4-{H1-benzhydiyl-S-chloro-2-(2-{[(2,4- dichlorophenyl)sulfbnyl](amino}ethyl)-1 H-lndol-3-yf]propyl)benzolc acid Step 1: To methyl 4-{2-{2-2-aminoethyl)-1-benzhydryl-5-chloro-1H-lndol-3- yl]propyl}benzoate (Step 6, Example 42) was acided and 2,4-dichlorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 95% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 77% yield. HRMS calc for C39H33CI3N2O4S. 730.1227; found (ESK), 731.1299. Example 153: 4-{3-[1-benzhydryl-5-chloro-2-(2-a(2,6- dichlorophenyl)sulf6nyl]amino}etriyl)-1H-indol-3-yl]propyl}benzoicacld Step 1: To methyl 4-{2-{2-{2-aminoethyl)-1-benzhydryl-5-chloro-11H-indol-3- yl]propyl}benzoate (Step 6, Example 42) was acided and 2,6-dichlorobenzenesurfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 93% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 71% yield. HRMS calc for C39H33CI3N2O4S. 730.1227; found (ESI+), 731.13005. Example 154: 4-{3-[1-*)enzhydryi-5-chloro-2-(2-([(2,4,6- trichioroplwnyl)sulfof-ani]no}ethyl)-1H-iridol(3-yl]propy1}benzoic acid Step 1: To methyl 4-{2-{2-(2-aminoethyl)-1-benzriydryl-5-chloro-1H- indol-3-yl]propyl]benzoate (Step 6, Example 42) was acided and 2,4.6- tricNorobenzenesulfonyt chloride according to the procedure in Example 1 Step 7 to generate the product in 76% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 84% yield. HRMS calc for C39H32Cl4N2O4S, 764.0837; found (ESI+), 765.08981. Example 155: 4-{3-[1-oenznydryl-6-chloro-2-(2-([(2. cyanophenyt)sulfonyl]ainino}ethyl)-1H-indol-3-yl]propyl}benzoic acid Step 1: To methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]propyl}benzoate (Step 6, Example 42) was acided 2-cyanobenzenesurfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 67% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 and purified by prep HPLC to afford the title acid in 8% yield. HRMS calcd for C4oH34CIN304S, 687.1959; found (ESI+), 688.2019. Example 156:4-(3-{2-I2-({r2-(eminomethyl)phenyfJsulfonyl}amino)ethyl]. 1-benzhydryl-6-chloro- 1H-fndol-3-yr}propy1)benzoic acid Stepi: Methyl 4-{3-{1-benzhydryl-5-chloro-2-(2-{I(2- cyanophenyl)sulf(xiynamino}ethyl)-1Wndol-3-yr|propyl}benzoate (Example 154, Step 1, 0.43 g, 0.61 mmoO was dissolved in THF (4 mL) and MeOH (12 mL). Cobalt (II) chloride (0.16 g, 1.2 mmol) and NaBK, (0.23 g, 6.1 mmol) were acided. After 2 h the mixture was filtered, concentrated, and chromatographed on silica gel (MeOH- CHaCl2) to afford the amino ester in 13% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 59% yield. HRMS calcd for C39H36CIN3O5S, 693.2064; found (ESI+), 694.21261 Example 167: 4-TX1-ben2hydrvl-2-{2-e1f1t-l)lpheny1-2. ylsulfo)nyl)amino]ethyf)-6-chloro-1ff4ndol-3-l)propyf]benzoic acid Step 1: 2-Bromobfphenyl (0.55 mL, 3.2 mmol) was dissolved in THF (10 mL) and Et2O (10 mL) and cooled at -78'C while n-BuU (1.3 mL of 2.5 M solution in hexanes, 3.2 mmd) was acided rapidly dropwise. After 40 min, the mixture was acided via cannula to a -78 °C solution of SO2 (10 mL) in EfcO (20 mL). The mixture was wanned to room temperature overnight, concentrated, and triturated with EUO- The resulting white solid was suspended in hexane (40 mL) and cooled at 0 °C. Sutfuryl chloride (3.4 mL of 1.0 M sdn. in CH2CI2, 3.4 mmol) was acided and the mixture was stirred at room temperature for 5 h. It was then concentrated to afford 2- biphenyteulfonyl chloride in 67% yield. Step 2: To methyl 4--2-2-aminoethyl)-1-ben2hydryJ-5-chloro-1H-indoJ-a- yl]propyl]benzoate (Step 6, Example 42) was acided 2-biphenylsulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 83% yield. Step 3: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 98% yield. HRMS calcd for C45H39CIN2O4S, 738.2319; found (ESI+), 739.23825. Example 158: 4-{3-{1-benzhydryl-2-(2-a(2. bromophenyl)sulfonyl]amino}ethyl)-5-chloro-1H-indol-3-yl]propyl)benzolcacid Step 1: To methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indok3- yl]propyl]benzoate (Step 6, Example 42) was acided 2-bromobenzenesulfonyl chloride according to the procedure in Example .1 Step 7 to generate the product in 76% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 95% yield. HRMS calcd for C39H34BrCIN2S, 740.1111; found (ESI+), 741.11696. Example 159: 4-{2-{1-benzhydryl-6-chloro-2-(2-{n2.4- dichlorophenyf)sulfdnyl]amlno}ethyl)-1 H-indol-3-yl]ethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-I2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl}ethoxy}ben2oate (Step 6, Example 1) and 2,4- dichlorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 83% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 80% yield. HRMS calc for C35H31Cl3N2O6S. 732.1019; found (ESI+), 733.10824. Example 160: 4-(2-[1-benzhydryl-e-chloro-2-(2-{[(2,6- dichlorophenyl)surfonyrjamlno}ethyl)-1H-lndol-3-yl]ethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aniinoethyl)-1- ben2*iydry-5-loro-1H-indol-3-y0ethoxy}benzoate (Step 6. Example 1) and 2,6- dichlorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 77% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 82% yield. HRMS calc for C38H31Cl3N2O5S, 732.1019; found (ESI+), 733.10836. Example 161: 4-{2-{1-benzhydryl-5-chloro-2-(2-{[(2,4,6- trichlorophenyl)sulfonyl]ajnlno}ethyl)-1 H-indol-3-yl]ethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-[2-{2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2,4,6- trichlorobenzenesutfonyl chloride according to the procedure in Example 1 Step 7 in 90% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 87% yield. HRMS calcd for C38H30Cl4N2O5S, 766.0630; found (ESI+), 767.07063. Example 162: 4-{2-[1-benzhydryi-5-chloro-2-(2-a(2- cyanophenyl)sulf6nyfjamino}ethyl)-1H-indol-3-l]ethoxy}benzoicacid Step 1: This compound was prepared from methyl 4-{2-(2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indo-3-yl}ethoxy}benzoate (Step 6, Example 1) and 2- cyanobenzenesutfonyl chloride according to the procedure in Example 1 Step 7 in 82% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 and purified by prep HPLC to afford the title acid in 17% yield. HRMS cated for C-H32CIN3O5S, 689.1751; found (ESI+), 690.18082. Example 163: 4-2-2-2-({I2-(aminornethyl)pheny1)suK6nyl)amino)ethyl]- 14ienzhydryl-6(hlon)-1/Mndol-3-Qethoxy)benzoic acid Step 1: Methyl 4-{2-{1-benzhydryl-5-chloro-2-(2-{[(2- cyarx)phenyl)sulf6nyl]ainirK)}ethyl)-1H-i-- (Example 161, Step 1,0.31 g, 0.44 mmol) was dissolved in THF (4 mL) and MeOH (12 mL). Cobaft (II) chloride (0.11 g, 0.88 MMOL) and NaBH4 (0.17 g, 4.4 mmol) were acided. After 2 h the mixture was filtered, concentrated, and chromatographed on silica gel (MeOH- CH2CI2) to afford the amino ester in 17% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 39% yield. HRMS calcd for C39H36CIN3O5S 693.2064; found (ESI+). 694.21261. Example 164: 4-[2-(1-benzhydryl-2-{2-[(1,n2blphenyl.2- ylsulfony1)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoic acid Step 1: The sulfonamide was prepared from methyl 4-{2-[2-(2-aminoethyl)-1- benrhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2- biphenylsulfonyl chloride (Step 1, Example 156) according to the procedure in Example 1 Step 7 in 93% yield. Step 3: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 94% yield. HRMS calcd for C44H37CIN2O5S, 740.2112; found (ESI+), 741.21709. Example 165: 4-{2-{1-benzhydryl-2-(2-{[(2- bromophenyl)surfony1]amino}ethyl)-5(chloro-1 f/-indol-3-yl]ethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-[2-[2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indo»-3-yI]ethoxy}benzoate (Step 6, Example 1) and 2- bromobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 90% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 91% yield. HRMS calcd for C38H32BrCIN2O5S, 742.0904; found (ESI+), 743.09697. Example 166:4({H1-benzhydiyt-chloffo-2-(2-{K5-chloro-2,4- drr1uoropnenyf)sulf6nyf]amlno}ethylH-ndol-3-Qpropyl}berizoic acid Step 1: To the methyl 4-{3-{2-(2-aminoethyf)-1-benzhydry1-5-chloro-1H-indol-3- yl]propyl}benzoate (Step 6, Example 42) was acided and 5-chforo-2,4- difluorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 68% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 44% yield. HRMS calc for [C3eH32CI22N2O4S + H] 733.15007 found 733.14978. Example 167:4-(H1-bEnzhydryi-5-chloro-2-(2-{[(2-methoxy-4- methylphenyl)surfony1]amino}ethyl)-1H-indol-3-yfJpropyl)benzoicacid Step 1: To the methyl 4-{3-[2-{2-aminoethyt)1-benzhydryl-5-chloro-1H-indol-3- yfjpropyl}benzoate (Step 6, Example 42) was acided and 2-methoxy-4- methylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 86% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 39% yield. HRMS calc for [C41H39CIN2O2S + H] 707.2341 found 707.23407. Example 168:4-{H1-benzhydryl-6-chloro-2-(2-a(4-hloro-2)5- drfluoroptionyl)8Ulfonyl]amino}ethyl)-1-ndol-3-yl]propyl}benzoicacid Step 1: To the methyl 4-{3-{2-(2-aminoethy()-1-ben2hydry1-5-chloro-1l--Indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided and 4-chloro-2,5- difluorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 79% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 63% yield. HRMS calc for [CMH32CI2(2N2O4S + H] 733.15007 found 733.14882. Example 169:4-{2-I1-Benzhydryl-6-chloro-2-(2-{I(5-chloro-2r4- drfluorophenyl)sulfonyl]amlno}ethyl)-1-ndol-3-qethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminorthyl)-1- berehydryl-5-k)ro-1H-indol-3-yl)ethoxy}benzoate (Step 6, Example 1) and 5-chloro- 2,4-difluorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 38% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 31% yield. HRMS calc for [C38H30Cl2F2N2O5.S + H] 735.12933 found 735.12824. Example 170:4-{2-[1-)enzhydryl-5-chloro-2-(2-{[(4-chloro-2,5- dIFluorophenyl)surfony1]Amlno}othylHW-indol-3-yl]ethoxy}benzoicacid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aminoethyt)-1- benzhydryl-5-chloro-1HNndol-3-yrjothoxy}ben2oate (Step 6, Example 1) and 4-chioro- 2,5-drfluorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 79% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 63% yield. HRMS calc for [C38H30Cl2F2N2O5S + H] 735.12933 found 735.12913. Example 171:4-{2-{1-benzhydryl-5-chloro-2-(2-(l(2-methoxy-4- methylphenyl)sulfonyl]amlno}ethyl)-1M-fndol-3-yl]ethoxy}benzoicacid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2- methoxy-2-methylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7. Step 2: The crude ester intermediate was hydrolyzed according to Step 8 Example 1 to afford 407mg of the title acid in quantitative yield. HRMS calc for [C40H.37CIN2O6.S + H] 709.21337 found 709.21194. Example 172:4-{3-[1-benzhydry1-5-chloro-2-(2-(I(7-chloro-2,1,3- benzoxadiazoM-)sulfonyf]anUno}ethylHH4ndol-3-qpropyt)benzolc acid Step 1: To the methyl 4--2-[2-amirK)ethyl)-1-boru*ydryt-5-loro-1H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided 4-chlon)7-chlorosulfonyl-2,1,3- benzoxadiazole according to the procedure in Example 1 Step 7 to generate the product in 43% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid m 26% yield after HPLC separation. HRMS calc for (C39H32Cl2N4O5S + H] 739.15433 found 739.1537. Example 173:4-(H1-*)enzhydiyl-5-chloro-2-(2-{[(7-methoxy-2f1,3- benzoxadiazoM-I)surfonyl]amino}ethylHH-indol-3-yf]propyf}benzoic acid Step 1: To the methyl 4-2--2-aminc)othyl)-1-benzhydry)-5(hloro-1H-irKlc4-3- yl]propyL}benzoate (Step 6, Example 42) was acided 4-chloro-7-chlorosulfonyl-2,1,3- benzoxadiazole according to the procedure in Example 1 Step 7 to generate the product in 43% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 36% yield after HPLC separation. HRMS calc for [C4oH35CIN406S + H] 735.2046 found 735.2029. Example 174:4-2-{1-benzhydryl-5-hlorc)-2-(2-a(7-chloro-2,1,3- benzoxadiazoM-yl)eutf6nyl]ainino)ethyl)-1H-lndol-3-yl]ethoxy)benzoJc acid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indo(-3-yl]ethoxy}benzoate (Step 6, Example 1) and 4-chloro- 7-chlorosulfonyJ-2,1,3-benzoxadiazole according to the procedure in Example 1 Step 7 in 56% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 30% yield after HPLC separation. HRMS calc for [C38H30CI2O6S + H] 741.1343 found 741.1328. Example 175:4--1-benzhydryl-6-chloro-2-2-[I(7-methoxy-2,1,3- borizoxadiazol-4-)suifonyfJamino}ethylHH4ndol-3-yl]ethoxy}benzolc acid Step 1: This compound was prepared from methyl 4-{2-J2-(2-amlnoethyl)-1- ben2hydryL-5-chloro-1H-indol-3-yI]ethoxy}benzoate (Step 6, Example 1) and 4-chJoro- 7-chlorosulfonyl-2,1,3-benzoxadiazole according to the procedure in Example 1 Step 7 in 56% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 36% yield after HPLC separation. HRMS calc for [C39H33CIN4O7.S + H] 737.1838 found 737.1819. Example 176:4-1-beizhydryl-chloro-2-{[5-(2-methyl-1,,3-thiazol- 4-)thfen4tyl]sulfonyf}amlno)efhyl]-1H-indol-3-yl}propyl)benzioic acid Step 1: To the methyl 4--[2-(2-aminomethyl)-1-ben2hydryt-5-chloro-1H-indol-3- yfJpropyl]benzoate (Step 6, Example 42) was acided 5-(2-methyl-1 ,3-thiazol-4-yl)- thiophene-2-sutfonyi chloride according to the procedure in Example 1 Step 7 to generate the product in 90% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C41H36CIN3O4S, + H] 766.1636 found 766.1629. Example 177:4-2-{1-benzhydryl-5-chloro-2-I2-({I5-(2-methyl-1,3-thlazol- 4-yl)thien-2-yl]surfonyl}amino)ethyl]-1H-ndol-3-yt)ethoxy)benzoic acid Step 1: Tills compound was prepared from methyl 4-{2-[2-(2-aminoethyl)-1- benzhydryl-5-loro-1H-indol-3-y|]ethoxy}benzoate (Step 6, Example 1) and 5-(2- methyl-1,3-thiazoM-yl)-thiophene-2-sulfonyl chloride according to the procedure in Example 1 Step 7 in 100% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 92% yield. HRMS calc for [C40H34CIN3O5S3 - H] 767.1269 found 766.1259. Example 178:4-{2-(1-benzhydryl-5-chloro-2-{2-{(thien-3- yl*urfonyl)emino]ethyl}-1H-indol-3-yl)ethoxylbonzolc acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl)ethoxy}benzoate (Step 6, Example 1) and 3- thiophenesuffonyl chloride according to the procedure in Example 1 Step 7 in 91% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 96% yield. HRMS calc for [C35H31CIN2O5S2 + H] 671.14357 found 671.1428. Example 179:4-2-1-benzhydryl-5-hloro-2-(2-CI(6-morpholin-4- ylpyridliv4-yl)eulfonyrjamlno)-hyl)-1H-lndol-3-yllethoxy)benzolc acid Step 1: This compound was prepared from methyl 4-{2-[2-(2-arninoethyl)-1- benzhydryl-5(hloro-1H-indol-yl]ethoxy}benzoate (Step 6, Example 1) and 6- morpholino-3-pyridinesutfbnyl chloride according to the procedure in Example 1 Step 7 in 91% yield. Step 2: The ester intermediate was hydrotyzed according to Step 8 Example 1 to afford the title acid in 92% yield. HRMS calc for [C41H30CIN4O6.S + H] 751.23516 found 751.2345. Example 180:4-fX1-benrhydryl-5-chloro-2-{2-[(thien-3- ylsulfonyl)amino]ethyl}-1H-indol-3-1)propyl]benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl]-1-benzhydryl-5-chloro-1H-indol-3- yl]propyl}benzoate (Step 6, Example 42) was acided 3-thiophenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 87% yield. Stop 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 99% yield. HRMS calc for [C37H33CIN2O4S2 + H] 669.16431 found 669.1629. Example 181:4-(H1-benzhydfyl-C-chloio-2-(2-{[(6Hnorpholin-4- ylpyrfdin-3-yl)sulf6nyl]amino}ethyl)-1 H-indol-3-yl]propyf}benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethylh1-benzhydry|.5-chtoro-1H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided 6-morpholino-3-pyndinesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 79% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 89% yield. HRMS calc for [C42CIN4O5S + H] 749.2559 found 749.255. Example 182:4-(2-C1-Ben2hydryl-2-{2-(benzo[1,2,5loxadlazole-4- sulfonylamlno)-ethyl]-6-chloro)-1H-indol-3-yl}-thoxy)ben2oic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-amlnoethyl)-1- benzhydryl-5(-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and benzofuran-4-sulfonyl chloride according to the procedure in Example 1 Step 7 in 88% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 94% yield. HRMS calc for [C38H31CIN4O6S + H] 707.17256 found 707.1719. Example 183: -(3-{1-Benzhydryl--2-[2benzoIIASJoxadlazole-i- sulfonylamino)-ethyfJ-6(hloro-1H-indol-)l-3-r)i)ropy0benzolc acid Step 1: To the methyl 4-[2-2-aminoemy1-1-benzhydryl-5-k)ro-1H-indol-3- yl]propyl}benzoate (Step 6, Example 42) was acided benzofurarv4-sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 69% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 93% yield. HRMS calc for [C39H33CIN4O5S + H] 705.1933 found 705.1931. - Example 184:4-(2-{1-Benzhydryl-2-[2-(2-benzyloxy- berizen»surfonylamino}-ethyl]-5-chloro-1 H-lndol-3-yl}-ethoxy)benzoic acid Stepi: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-i- benzhydry(-5-chloro-1H-ndol-3-yi]ethoxy}benzoate (Step 6, Example 1) and 2- benzyloxy-benzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 87% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 95% yield. HRMS calc for [C45H39CIN2O(SS - H] 769.21446 found 769.2129. Example 185:4-(2-{1-Bonzhydryl-5-chloro-2-{2-(2-l8opropoxy- benzenesulfonylarriino)-ethyl]-1H-indol-3-yl)-ethoxy)benzoic acid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aminoethyl)-1 - bernzhydry(-5-chk)ro-11H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2- isopropoxybenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 88% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 74% yield after trturation with ethylether. HRMS calc for [C41H39CIN2O6S + H] 723.22902 found 723.2284. Example 186:4-3-{1-Benzhydryl-6-chlon)-2-(2-(2-isopropoxy- berizenesurfonylemino)-ethyl]-1H-lndol-3-yl}-propyl)benzoic acid Step 1: To the methyl 4--2-2-aminoethyl)-14)enzhydryl-5-chloro-1H-indoI-3- yrjpropyl]benzoate (Step 6, Example 42) was acided 2-isopropoxybenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 71% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 82% yield after HPLC purification. HRMS calc for [C42H41CIN2O5S -i- H] 721.24975 found 721.2490. Example 187:4-(3-{1-Benzhydryl-2-{2-(2-benzyloxy- benzenesulfonylamino)-ethyf]-5-ehloro-1 H-lndol-3-yl}-propy1)benzoic acid Step: To the methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided 2-benzyloxy-benzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 57% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 97% yield after HPLC purification. HRMS calc for [C48H41CIN2O5S + H] 769.2505 found 769.2494. Example 188:4H3-(1-6enzhydryl-2-{2-(2-hydroxy- benzenesulfonylamlno)-0thyl]-1H-indol-3-IH)ropylH)enzolc acid Step 1: The benzyl group from step 1 Example 186 was removed by hydrogenolysis. The crude was purified on sffica gel column with CH2Cl25% EtOAc/CHaCl to get a mixture which was further purified by HPLC to obtain 4-(3-[1-Benzhydiyt-2-{2-(2- hydroxy-berizeresutfonylamino)-ethyl]-1H-i-- acid methyl ester (7%) and 4-3-1-Benzhydryl-5-chloro-2-2--nydroxy-benzenesulfonylamino)- ethyl]-1H-iraiol-3-ylhpropyl)benzoic acid methyl ester (18%) Step 2: The 4-(3-{1-Benzhydryl-2-l2-(2-hydroxy-benzenesulfonylamino))- ethy!}-1H-indol-3-yl)-propyl)ben2oic acid methyl ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 81 % yield. HRMS calc for [C39H35N2O5S + H] 645.2418 found 645.2423. Example 189:4-(3-{1-Ben2hydryl-5-chloro-2-C2-(2-hydroxy- b*nzenesulffony1amirio)-thy1])1H-ndol-3(y1}-propyl)b»nzolc acid Step 1:4-3K1-Benzhydryl-5-chlon)-2--24hydroxy)enzeriesulfonylamino)- ethyfh1H-indo(-3-yl}-propyl)benzoic acid methyl ester intermediate from step 1 of Example 187 was hydrolyzed according to Step 8 Example 1 to afford the title acid in 86% yield. HRMS calc for [C39H35CIN2O5S + Hj 679.2028 found 679.2038. Example 190:4-(2-(1-Benzhydryl-5-chloro-2-{2-(2-chloro- benzenesulfnylamino)-ettiyl]-1 H-lndol-3-yl}-ethoxy)-2-fluoro-benzoic acid Step 1: To a solution of Ph3P (698 mg, 2.7 mmote, 2.0 equlv.) In THF (10 ml) was slowly introduced diisopropylazodicarboxylate (0.55 ml, 2.7 mmole, 2.0 equiv.) at 0°C under N2. It was allowed to stir for 15 min. A solution of 2-{1-Benzhydryl-2-[2- (tart-buty-diphenyl-silanyloxy)-ethyl]5-chloro 1H-indol-3-yl+}ethanol(859 mg, 1.3 mmote, 1.0 equtv. Step 6, Example 142) in THF (5 ml) was transferred to Mitsunobu reagents, followed by 2-fluoro-4-hydroxy-benzoic acid methyl ester (340 mg, 2.0 mmote, 1.5 equiv.). The resulted solution was stirred overnight. THF was removed. The residues were partitioned between EtOAc and water. The organic pHase was washed with water and brine, dried over MgSO4. The product was purified on silica gel column with 8% EtOAc / hexane. 0.95 g (90%) of product was obtained as a white solid. Step 2: The 4-2-1-Benzhydryl-2-I2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5- chloro-1 Hindol-3-yl}-ethoxy)-2(fluoro-benzoic acid methyl ester was deprotected according to the procedure in Example 142, step 9 to yield 4-{2-l1-Benzhydryl-5- chloro-2-2-ydroxy-thyl)-1H-indol-3-yI]-ethoxy-2-fluoro-benzoic acid methyl ester in 89% yield. Step 3:4--1-Beru-ydryl-5-chl()ro-2-[2-ydroxy-ethyl)-1H-indol-3-yl]- ethoxy}-2-fluoro-benzoic acid methyl ester was activated by conversion to the mesylate following the procedure in Step 10 Example 142 and the resulting product was used crude in the next step. Step 4: The mesylate from above was displaced with azide as described in Step 11 Example 142 to generate 4-{2-{2-(2-Azido-ethyl]-1-benzhydryl-5-chloro-1H- indol-3-yll-ethoxy)-2-fluoro-benzoJc acid methyl ester in 97% yield (over two steps). Step 5: The 4---2-Azklo-thy-1-Bennzhydryl-5(hloro-1H-indol-3-vO- ethoxy}-2-fluoro-benzcoiC acid methyl ester was reduced under Staudinger conditions to yield methyl 4-2-2-mino-ethyl)-1-rahydryl-5M*- 2-fluoro-benzoate in 93% yield. Step 6: The methyl 4-H2--ino-ethyl-benzydryl-£- yI}-ethoxy}-2-fluoro-benzoate from above and 2-chloro-benzenesulfonyl chloride were reacted according to the procedure in Example 1 Step 7 to generate the desired product in 73% yield. Step 7: The ester intermediate was hydrdyzed according to Step 8 Example 1 to afford the title acid in 96% yield. HRMS calc for [C38H31Cl2FN2O5S + H] 717.13876 found 717.1365. Example 191:4-(2-{1-Benzhydryl-5-chloro-2-I2-(2-chloro-6-m©thyl- benzenosuffonyiamlnoHthyf]-1H-lndol-3-yf}-ethoxy)-2-fluoro-benzolcacid Step 2: This compound was prepared from methyl 4-{2-{2-(2-amino-ethyt)1- benzhydryl-5-lofO-1H-indc)(-3-yl]-ethoxy}-2-uoro4)enzoate (Step 5, Example 189) and 2-chlort)-6-methyl-benzenesutfonyl chloride according to the procedure in Example 1 Step 7 in 66% yield. Step 3: The ester intermediate was hydroJyzed according to Step 8 Example I to afford the title acid in 95% yield HRMS calc for [C39H33Cl2FN2O5S + H] 731.15441 found 731.1532. Example 192: N-{2-(1-*bn2hydryl-5-chloro-H2(4-(2H-tetniazol-6- yl)phenoxy]ethyl)-1H-lndol-2-y1)ethyl]-1-(3,4- dichlorophenyl)metHaneeiilfonamlde Step 1: The 2-1-benzhydryl-2-[2-tert-butyl-diphenyl-nytoxy)thyl]-5-loro-1 H- indol-3-yf}-etHanol (Step 6, Example 142) was coupled with 4-Hydroxy-benzonitrite according to the conditions described in Example 189, Step 1 to yield 4-(2-{1- Benzhydryl-2-tert-butyl)diphenyl*tfanylow- benzonitrile in 85% yield. Step 2: The silyl ether from above was deprotected folowing the Example 142, step 9 to yield 4-2-1•eenzhydryt-5-chloro-2-(2-hydoxy-ethyl)-1H-indol--3-yl]-ethoxy- benzonitrile in 93% yield. Step 3: The alcohol from above was activated by conversion to the mesytate as described in Step 10 Example 142 to yield the desired mesylate which was used without purification in the next step. Step 4: The mesylate from above was treated under the conditions described in Step I1 Example 142 to generate 4-2-(2-Azkdo-thyI)1-benzhydryl-5-creloro-1H-indol- 3-yl}-ethoxy}lnzonitrile in 91% yield (2 steps). Step 5:4---2-Azklo-thyl).1-benzhydryl-5-loro-1H-indol-3-yn-thoxy) benzonitrile was reduced under Staudinger conditions as detailed in Step 12, example 142 to yield 4-{2-{2-(2-amino-ethyl)-1-benzhydryl-5-chloro-1H-lndol-3-yl]- ethoxy}benzonitrile in 92% yeild. Step 6: The 4-242-2-mino-ethyl)-1-benzhydryl-5-chloro)-1H-indol-3-yl]- ethoxy}benzonftrile from above and (3,4-dicf)loro-phenyl)-metHanesulfony1 chloride ware reacted according to the procedure in Example 1 Step 7 to yield the desired product in 82% yield. Step 7: The mixture of nitrite (1.0 equiv.), azkdotrimethytsilane (2.0 equlv.), dibutyttin oxide (0.1 equiv.) and toluene (3.3 ml/mmote) in a sealed tube was heated at 120°C for 20 hours. It was acidified with 1 N Ha at room temperature, then diluted with EtOAc. The organic pHase was washed with water and brine, dried over MgSO4. The crude tetrazole was chromatographed with 50% EtOAc/hexanes - 80% EtOAc/hexanes plus 0.5% of acetic acid to afford the title product in 58% yield HRMS calcfor [C39H33Cl3N6O3S + H] 771.14732 found 771.1475. Example 193: N-K1-beiuhydryl1-5-chloro-3--4-2H-tetrazol-6-vt)- phenoxy]-ethyl}-1 H-ndol-2-yl)-ethyl]-2'Chlorobenzenesulfonanilde Step 1:4-42-2-amino ethyl)-1-bendryl-5-chloro-indol--yl} ethoxy}benzonitrile (Step 5, Example 191) and 2-cntoro-benzenesulfonyl chloride were reacted according to the procedure In Example 1 Step 7 to yield the desired product in 77% yield. Step 2: The nitrite from above was converted to tetrazole according to Step 7 of Example 191 to afford the title product In 45% yield. HRMS calc for [C38H32Cl2N6O5S + H] 723.17065 found 723.1711. Example 194: N-£2-(1-benzhydryl-5-chloro-H2-{4-2H-tetreazol-6- yl)phenoxy]ethyn-1H -indol-yl- Step 1: The 4-2-K2-amirK)-ethyI)-1-benzhydrol-5-toro-1H-indol-3-yl- ethoxy}benzonrtrite (Step 5, Example 191) and 1-butanesuHbnyi chloride where reacted according to the procedure in Example 1 Step 7 to yield the product in 79% yield. Step 2: The nitrite was converted to tetrazole according to Step 7 of Example 191 to afford the title product in 91% yield HRMS calc for [C36H37CIN5O5S + H] 669.24092 found 669.2409. Example 195: N-(2-(1-benzhydryl-6-chloro-3-{2-[M2H-tetraazol-5- yl)pHanoxy]ethyl1H-ndol-2-)ethyl]-2(2,24trifluoroetthaiesurfonarnlde Step 1: The 4-242-2-amino-ethyl]-1-benzhydryl-5-chloro-1H-indol-3.yl]- ethoxyjbenzonitrile (Step 5, Example 191) and 2,2,2-trifluoro-etHanesutfonyi chloride where reacted according to the procedures Example 1 Step 7 to yield the desired product in 64% yield. Step 2: The nitrite was converted to tetrazote according to Step 7 of Example 191 to afford the title product in 77% yield HRMS calc for [C34H30CIF3N5O3S + H] 695.18135 found 695.1807. Example 196:4-(2-{1-Ben2hydry1-5-chloro-2-2-(2,4,6-trifluoro- benzenesurfonylamino)-ethyl]-1H-lndol-3-l}-ethoxyH)enzoic acid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aminoethyl)-1- beruhydryf-5-chloro-11H-indol-3-yl}ethoxy}benzoate (Step 6, Example 1) and 2,4,6- trifluorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 92% yield. Step 2: The ester intennediate was hydrolyzed according to Step 8 Example 1 to afford the title acid In 92% yield. HRMS calc for [C38H30lCIFN2O3S + H] 719.15889 found 719.15843. Example 197:4-(2-{1-Benzhydryl-6-chloro-2-[2-(4-methoxy-2- nttro-nzenesulfonylamino)-ethyl]-1H4- acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryt-5-cWon)1H-ndo4-3-y1]ethoxy}benzoate (Step 6, Example 1)and 4- methoxy-2-nltrobenzenesulfonyl cMoride according to the procedure in Example 1 Step 7 in 74% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 94% yield. HRMS calc for [CmHmCIN3O.S + H] 740.1828 found 740.1834. Example 198:4-(2-f1-Benzhydryl-S-chloro-2-C2-(3-trifIuoromethoxy- tonzenesulfonytaminofethyl]-i H-lndol-3-y1}-ethoxyH)enzolc acid Step 1: This compound was prepared from methyl 4-{2-{2-{2-aminoetriyl)-1- benzhydryl-5-chloro-1H-indol-3-ytlethoxy}benzoate (Step 6, Example 1) and 3- (trfluoromethoxylbenzenesutfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 86% yield. HRMS caic for [C39H32CF3N2O5S + H] 771.1514 found 771.1512. Example 199:4-3-{1-Benzhydryl-5-chloro-2-p-(2A64rtfiuoro- Donzeneeulfonyiamlno)-ethyl]-1H-lndol-3-yl)-propylH)en2olcacld Step 1: To the methyl 4-[2-[2-(2-aminoethyl)-1-benzhyclryl-&-chloro-1H-indol- 3-yl]propyl]benzoate (Step 6, Example 42) was acided and 2,4,6- trifiuorobenzenesulfonyf chloride according to the procedure in Example 1 Step 7 to generate the product in 61% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 97% yield. HRMS calc for [C39H32CF3N2O5S + H] 717.17962 found 717.17913. Example 200:4-3-1-Benzhydryl-5-chloro-2-p-(4-methoxy-2-nltro- benzenesuHonylamlno)-ethyl]-1H-indol-3yl}-propyl)-benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-ben2hydryl-5-chJoro-1 H-indot- 3-yl]propyl]benzoate (Step 6, Example 42) was acided 4-methoxy-2- nitrobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 81% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 95% yield. HRMS calc for [C39H32CF3N2O5S + H] 738.2035 found 738.2028. Example 201:4-(H1-Benthydryl-6-chloro-2-[2-(3-trit1uorofnethoxy- benzenesulfonylamlno)-ethyl]-1H-indol-3-yl}-propyl)-benzoic acid Step 1: To the methyl 4-{2-{2-{2-aminoethyl)-1-benzhydryt-5-chloro-1H-indol- 3-yl]propyl}benzoate (Step 6, Example 42) was acided 4-methoxy-2- nitrobenzenesuffonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 83% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 91% yield. HRMS calc for [C39H32CF3N2O5S + H] 747.19019 found 747.18996. Example 202: 4-C2-{1-Benzhydryi-5-chloro-2-{2-[({4- methysulfonylbenzene}-sulfonyl)amino]ethyl}-1 H-Jndol-3-yi) propyl]benzole acid Step 1: To the methyl 4-{2-{2-{2-aminoethyJ)-1-ben2hydryl-5-chloro-1H-indol- 3-yl]propyl]benzoate (Step 6, Example 42) was acided 4- methysulfonybenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 741.18544 found 741.18421. Example 203:4-p-(1-Benzhydryl-2-{2-[(4-methylsulfonylbenzene}amino]- •tliyl}-6-chloro-1H-lndol-3-y1)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl]-1- benzhyclryl-5(Noro-1H-indol-ylIethoxy}benzoate (Step 6, Example 1) and 4- methyteuffonylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 741.15014 found 741.14842. Example 204: 4-(2-I1-Benzhydryl-5-chloro-2-{2-[{{2- methylsulfonylb6nzene}-(ulfony1)amino]ethyl}-1H-indol-3-l) propyfjbenzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided and 2- methyteulfonybenzenesulfonyl cNoride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 741.18544 found 741.18425. Example 205:4-{2-(1-Benzhydryl-2-{2-{(2-methylsulfonylbenzene)- amino]ethyl)-5-hloro-1H-lndol-3-yl)ethoxy]ben2olc acid Stepi: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-y1]ethoxy}ben2oate (Step 6, Example 1) and 2- methylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title ackJh 90% yield. HRMS calc for [C30H.385N2O7S2-i-H] 743.16470 found 743.16431. Example 206:4-{2-{1-Bwizhydryl-S-chloro-2-{2-I({3- phenylsulfeiiylbenzene}-uH6nyl)amlno]ethyl)-1H-indol-3-yl) propyl]benzoic acid Step 1: To the methyl 4-42-2-aminoethyl)-1-benzhydryl-5(riloro-1 H-mdol-3- yl]propyl}benzoate (Step 6, Example 42) was acided and 3-phenylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Stop 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 739.23919 found 739.23896. Example 207:4-{2-1-Benzhydryl-2-{2-l(3- preenylsulf()nylbenzere)aiTiino)ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-[2-{2-{2-amJnoethyl)-1- benzhydryl-5-chIoro-1HHndot-3-yJlethoxy}benzoate (Step 6, Example 1) and 3- phenylbenzenesutfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C44H.S7CIN2O5S + H] 741.21845 found 741.21879. Example 208:4-{2-1-Benzhydryl-5-chloro-2-{2-{({2- trifluoRHnethylsulfonylbenzeneHiulfonyl)amino]ethyl}-1H-indol-3-yl) propyl]benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethy))-1-ben2hydryl-5-loro-1H-indof-3- yl]propyl]benzoate (Step 6, Example 42) was acided and 2- trifluoromethylsulfonybenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title acid In 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 731.19527 found 731.19591. Example 209:4-{2-(1-Benzhydry1-2-{2-£(2- trifluoronrathylaulfonylbenzene)amino]ethyl)-6-hloro-1H-lndol-3- yt)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5(hloro-1H-indol-3-yl]etrK)xy}benzoate (Step 6, Example 1) and 2- trifluoromethylbenzenesulfonyt chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester Intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid In 90% yield. HRMS calc for [C40H34F3CIN2O4S2 + H] 733.17454 found 733.17439. Example 210:4-{H1-benxhydryl-6-chloro-2-(2-a(5-methyl-1-phenyl-1H- pyrazol-4- yl)aurf6nyl]ainino}ethyl]indol-3-qpropyl}benzolc acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryl-5-chlorc-11H-indol- 3-yl]propyl]benzoate (Step 6, Example 42) was acided 5-Methyl-1-phenyHe- pyrazole-4-sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 93% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 99% yield. HRMS calc for [C39H32CF3N2O5S + H] 743.24533 found 743.24506. Example 211:4-{2-[1-benzhydryl-6-chloro-2-{2-a(5-n{[)thy1-1-phenyl-1H- pyrazoM- yl)suH6nyl]amino}ethylHH-indok3eyl]ethoxy)benzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-benzhydry]-5-hloro-1H-indol- 3-yl]ethoxy}benzoate (Step 6, Example 1) was acided 5-Methyl-phenyl H- pyrazole-4-sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 88% yield. Step 2: The ester intermediate was hydrolyzed according to Stop 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [[C39H32CF3N2O5S + H] 745.2246 found 745.22362. Example 212:4-{3-{1-ben2hydryl--chloro-2-(2-[[(1,3,6-trimethyl-1H- pyrazol--yl)surfony1]amino}ethylHH-indol-3-yl]propy1}benzoic acid Step 1: To the methyl 4-p-{2-(2-amlfX)ethyl]-1-benzhydryl-5-chloro-1H-indol- 3-yl]propyf}benzoate (Step 6, Example 42) was acided 1,5-Dimethyl-1H-pyrazole-4- suHbnyl chloride according to the procedure in Example 1 Step 7 to generate the product in 92% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 92% yield. HRMS calc for [C39H39CINO4S + H] 695.24533 found 695.24453. Example 213:4-{2-[1-benzhydryl-6-chk)ro-2-(2-a(1,3,6-trlmethyl-1H- pyrazol-4- y1)*ulfony1]amino}ethyJ)-1H-Jndol-3-y1]ethoxy}benzoic acid Step 1: To the methyl 4--[2-[2-amirwethyl)1-benzhydryI-5(rlloro-1H-indol- 3-yl]ethoxy}benzoate (Step 6, Example 1) was 1,5-Dimethyl-1H-pyrazole-4-sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 100% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 74% yield. HRMS calc for [C39H32CF3N2O5S + H] 697.2246 found 697.2241. Example 214:4-{3-[1-benzhydry1-5-chloro-2-(2-{[(2,3- dichlorophenyl)sutfdnyl]amino}ethylMH- indol-3-yl]propyl}benzoic acid Step 1: To the methyl 4-{2-[2-{2-aminoethyl)-1-benzhydry]-5-chloro-1H-indol- 3-yIJpropykl}benzoate (Step 6, Example 42) was acided 2,3-Dichloro-benzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 85% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 96% yield. HRMS calc for [C39H32CF3N2O5S + H] 729.1154 found 729.1135. Example 215:4-{2-{1-bonzhydryl-6-chloro-2-(2-(I(2f3- dichlorophenyl)sulf6nyl]amino}ethyl)-1H- indof-3-yl]ethoxy}benzoic acid Step 1: To the 4-242-2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]ethoxy}benzoate (Step 6, Example 1) was acided 2,3-Dichloro-benzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 79% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 97% yield. HRMS calc for [C39H32CF3N2O5S + H]] 731.0947 found 731.0930. Example 216:4-H1-nrhydryl-6-chloro-2-(2-[K4'-fluotx)-1,1f-blphenyl- 4-)sulfonyl]amlno}ethylH-indol--propyl}benzolc acid Step 1: To the methyl 4--2-[2-amirK)©thyl)-1-benzhydryt-5-chlc)rc)-1H-lndol-3- yl]propyl]benzoate (Step 6, Example 42) was acided and 4)-fluorophenyM- benzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 757.22976 found 757.22874. Example 217:4-(2-{1-benzhydryl-6-chloro-2-(2-{t(4(-fluoro.1,1*4)iphenyl- 4-yl)sutfonyl]amino}ethyl)-1H-indol-3-yl]ethoxy}t)6nzoic acid Step 1: This compound was prepared from methyl 4-[2-[2-{2-aminoethyl)-1- benzhydryt-5-chJoro-1H-lndol-3-yI]ethoxy}benzoate (Step 6, Example 1) and 4'- fluorophenyM-benzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 759.20903 found 759.20745. Example 218:4-{2-[1-Ben2hydryl-5-chloro-2-2-[({3- trif)uorornethylberizene)eulfony1)arnino]ethyt}-1H-ndol-3-y1) propyl]benzoic acid Step 1: To the methyl 4--K2-minoethyl)-1-ben2hydryl-5-chloro-1HHndo»- 3-yl]propyl}benzoate (Step 6, Example 42) was acided and 3- trifluoromethylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 731.19527 found 731.19582. Example 219:4-[2-(1-enzhydry1.2-(2-e3. trifluoromethylbenzene)ajnlno]emy1}- acid Stepi: This compound was prepared from methyl 4-{2-{2-(2-amlrK)ethyl)-1- benzhydryl-5-(-oro-1H-indol-3-yl]6thoxy}ben2oate (Step 6. Example 1) and 3- triflinromethylbenzenesuHonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 733.17454 found 733.17431. Example 220:4-{2-(1-benzhydryl--chloro.2-{2-£({I(3,4- dlchlorophenyl)thlo]rriathyl}sulfonyl)amlno]ethylh1H-indol-3-yl)ethoxyJbenzoic acid Stepi: To methyl 4-{2-{1-benzhydry(-5-chlorc)-2-(2- chlorometHanesulfonylamino-ethyl-iH-mdol-S-yl]-ethoxyH-nzoate, Example 81 stepi, was acided 3,4-dichlorothiophenol according to the procedure in Example 81 step 2. The crude was purified by the preparative HPLC in 24% yield of ester and 14% of acid. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1to afford the title acid in 97% yield, m/z (M-1)779.01. Example 221:4-|2-(1-benzhydryl-chloro-2-{2-C({[(3(hloro-4- fluorophenyl)thio]methyl)sulffonyt)ainino]ethyl]-1 H-indol-3- yl)ethoxy]benzoicacid Step: To methyl 4-{2-{1-benzhydryl-5-chloro.2-(2- chlo(onetHanesulfbnylamino-yl -1H-indol-3-yl}ethyl-}benzoate,Example 81 stepi, was acided 3-chloro-4-flurothiopherK)l according to the procedure in Example 81 step 2. The product was purified by flash column with 30% EtOAc/hexanes in 70% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 89% yield, m/z (M-1)760.94. Example 222:4-{2-{1-Berahydryl-6-chloro-2-{2-C({2-fluorobenzene}- •ulfonyl)amlno)ethyl}-1H-4ndol-yl) propyl]benzolc acid Step 1: To the methyl 4---2-aminoethyl)-1-befiz-ydryl-5-loro-1H-inc»ol-3- yl]propyl]benzoate (Step 6, Example 42) was acided and 2-fiuorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 681.19846 found 681.19854. Example 223:4--1-benhydryl-2-{2-{(2-fluoroben2en»)arnlno]ethyl}-5- chloro-1H-indol-3-yl)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- berizhydryl-5-chlon)1H-indol-3-y1]ethoxy}ben2oate (Step 6, Example 1) and 2- fluofobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydroJyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 683.17773 found 683.17694. Example 224:4-41-BenzhydryI-5-chloro-2-[2-I({2,6-dmuorobenzerie)- sulfonyl)amino]ethyl}-1H-indol-3-yl) propyfjbenzolc acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-benzhydryt-5-chloro-1 H-indol-3- yl]propyl]benzoate (Step 6. Example 42) was acided and 2,6-difluorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 699.18904 found 699.18850. Example 225:4-2-(1-enzhydfyl-2-{2-C(2,6- dtfluorobenzene)ajnino]emyr)-6(hloro-1H-4ndol--yl)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2(42-(2-aminoemyl)-1- benzhydryl-5(hloro-1H-indol-3-ylethoxy}benzoate (Step 6, Example 1) and 2,6- difluorobenzenesulfonyt chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the tWe acid h 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 701.16831 found 701.16849. Example 226:4-{2-{1-enzhydryl-6-chloro-2-{2-(({2-chloro-6. nriethylbenzene}*ulfbnyl)amlno]ethyl}-1H-indol-3-yl) propyfjbenzoic acid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-ben2hydryt-5-chloro-1 H-indol-3- yl]cropyl]benzoate (Step 6, Example 42) was acided and 2-chloro-6- methylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 711.18456 found 711.18404. Example 227:4-{2-(1-Benzhydry|.2-{2-[(2-chloro-6- methylbenzene)amino]ethyl}--chloro-1H-indol-3-yl)ethoxy]benzole acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydry]-5-chtoro-1H-indol-3-y0ethoxy}ben2oate (Step 6. Example 1) and 2-chloro- 6-methylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H]+ H] 713.16383 found 713.16269. Example 228:4-{2-{1-Benzhydry1-5-chloro-2-{2-{({4- trMuoromethylbenzene)eulf6ny1)amlno]ethyl}-1 H-lndol-3-yl) propyl]benzoic acid Step 1: To the methyl 4--K2-aminoethyl)1-benzhydryJ-5-chlorc)-1H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided and 4- trifluoromethylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the tide acid in 100% yield. HRMS cate for [C39H32CF3N2O5S + H] 731.19527 found 731.19580. Example 229:4-2-(1-Benzhydryl-2-{2-I(4- trifluoit)rnethylberaene)aniino]ethyl)-5-hloro-1H-indol-3-yl)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-amlnoethyl)-1- benzhydryl-5-chloro-1H-indol-3-y0ethoxy}benzoate (Step 6, Example 1) and 4- trffluoromethylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 733.17454 found 733.17432. Example 230:4-(2-{1-Benzfiydryl-5-chloro-2-{2-[({2- triftuoromethoxybenzene}-sulfony1)amino]ethyl}-1H-lndol-3-yl)propyrjbenzoic acid Step 1: To the methyl 4-{2-{2-{2-aminoeth-1-benzhydryl-5-chloro-11H-indol-3- y!]propyl}benzoate (Step 6, Example 42) was acided and 2- trifluoromethoxybenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 747.19019 found 747.18848. Example 231:4-{2-(1-Bonzhydryl-2-(2-[(2- trifluoromothoxybenzeiie)amino]ethyl}-6-chlofo-1 H-lndol-3-yf )ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2- trifluoromethoxybenzenesuifonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydroiyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 749.16945 found 749.16813. Example 232:4-(2-{1-B0nzhydryl-5-chloro-2-{2-(({2-mothyibon2ene). •urfonyl)amlno]ethyt}-1H-indol-3-yi) propyfjbenzolc acid Step 1: To the methyl 4-{2-P-(2-aminoethyl)-1-benzhydryt-6-chloro-1H-indol-3- yl]propyl}benzoate (Step 6, Example 42) was acided and 2-methylpenzenesutfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 677.22354 found 677.22244. Example 233:4-{2-(1-Benzhydryl-2-(2-[(2-methylbenzen6)amfno]ethyl)-5- chloro-1H-lndol-3-yI)ethoxy]benzolc acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryi-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2- methylbenzenesulrbnyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 679.20280 found 679.20197. Example 234:4-{2-[1-BenzhydryK6(chloR)-2-(2-{({2-mettioxybenzene}- suifonyl)amino]ethyl}~1H-indol-3-yl) propyl]benzoic acid Step 1: To the methyl 4-42-[2-aminc)ethyf)1-beruhydryl-5-chloro-1H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided and 2-methoxybenzenesurfbnyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 693.2185 found 693.21852. Example 235:4-[2-(1-Benzhydiyl-2-{2-{(2-methoxybenzorw)emino]ethyl)- 5-chloro-1H-indol-3-yt)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-(2-{2-(2-aminoethyl)-1- benzhydryl-5-chlon)1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2- methoxybenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydnolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 695.19722 found 695.19701. Example 236:4-2-1-rH*ydiyl-hloro-2-[24({2-tert*utylbenzene}- sulfonyl)amino]ethyf}-1H-indol-3-yl) propyl]benzoic acid Step 1: To the methyl 4-2-2-[2-aminoethyl)-1-benzhydry(-5-chloro-1H-indc))-3. yl]propyl]benzoate (Step 6, Example 42) was acided and 2-tert-butylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C39H32CF3N2O5S + H] 719.27049 found 719.27057. Example 237:4-{2-{1*en2hydryl-2-{2-I(24ert-butylbonzene)amlnolethyl}- 6-chloro-1H-[indoM-y1)ethoxy]benzolc acid Step 1: This compound was prepared from methyl 4-{2-P-(2-aminoethyl)-1- benzhydryt-5-chtoro-1H-ndol-a-yI]ethoxy}t)enzoate (Step 6, Example 1) and 2-tert- butylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C39H32CF3N2O5S + H] 721.24975 found 721.24907. Example 238:4-241-eruhydryl-6-chloro-2-{2-{({2wnethylthk)benzene}- suffony1)amino]ethyl1H-indol-3-y1) propyl]benzolc acid Step 1: To the methyl 4---(2-amim)ethyl)-14)enzhydryl-5(hlorc)-1H-indol-3- yl]propyl}benzoate (Step 6, Example 42) was acided and 2- methylthiobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for [C40H37CIN2O4S2 + H] 709.19561 found 709.19504. Example 239:4-{2-(1-Ben2hydryl-2-{2-[(2- methylthloberttene)amino)ethyl}-6-chlor()-1H-lndo1-3-y1)ethoxylben2oicacid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryf-5-chloro-1H-4ndol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2- methyfthiobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the tttte acid in 90% yield. HRMS calc for [C40H37CIN2O4S2 + H] 711.17487 found 711.17518. Example 240:4-(2-[1-enzhydryi-5-hlorx).2-{2-£({3-chloro-2- methylbenzene)-ulfbnyl)amino]ethyl}-1H-indol-3-y1) propyl]benzoic acid Step 1: To the methyl 4---2-aminoethyfV1-benzhydry-5-(-loro-1H-lndol-3- yl]propyf}benzoate (Step 6, Example 42) was acided and 3-chloro-2- methylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS cede for [C40H37CIN2O4S2 + H] 711.18456 found 711.18465. Example 241:4-{2-(1-Benzhydryi-2-{2-[(3-chloro-2- rnethylbenzene)amirK)]ethyl}-5-loro-1H-indol-3-yl)ethoxy]benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H(4ndol-3-yl]etrioxy}benzoate (Step 6, Example 1) and 3-chloro- 2-methylbenzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for [C40H37CIN2O4S2 + H] 713.16383 found 713.16296. Example 242: 4-2-(2-2-2-{4-cetyl-plperazin-1.yl). etHane8uHbnylamlnol-ethyl)-1-beiuhydryl-5-chloro-1H-lndol-3-yl)-ethoxy]- benzoic acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and 1-acetylpiperazine according to the procedure in Example 100 step 2 except tHat it was heated at 60 X for 19h in 91 % yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to the title acid in 19 % yield, m/z (M-1) 741.2 Example 243: 4-{2-(1-Benzhydryl-5-chlofo-2-{2-C2-(3,5-dimethyl- piperazin)1-yl)-etHanesulfonylamino]-ethy|}-1 H-indoW-yl)-ethoxy]-benzofc acid Step 1: The compound was prepared from the Intermediate from Example 100 step 1 and ds-2,6-dimethylpiperazine according to the procedure in Example 100 step 2 except tHat it was heated at 60 °C for 19h in 97 % yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to the title acid in 39 % yield, m/z (M-1) 727.2 Example 244: 4-[2-(2-{2-{2-(4-Acotyl-3l6-dimethyl-piperazin.1-yl). etnanesulfonytamirw]-ethyf)1-benzhydiyl- benzolcacid Step 1: To a solution of 4-{2-(1-benzhvdryl-5-diloro-2--K3.- yl)-tHanesulfonylamino}-ethyl]-11HrK-3yl]ethyl]benzoicacid methyl ester (Step 1, Example above) (31 mg, 0.042 mmol) in CH25Cl2 (1 mL) at 0 *C were acided EtsN (0.10 mL) and AcfeO (60 uL) and the reaction mixture was stirred at rt for 4h. Aqueous workup followed by silica gel chromatography (3.5% MeOH/MeOH) gave the desired ester intermediate (17 mg, 52% yield). Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to the title acid in 96% yield, m/z (M-1) 771.2. Example 245: 4-(2-{1-bertthydryl-5-chloix)-2-P-((I2-4-m©thy»plperidin-1- yi)ethyf]eulfonyi}amino)ethyf]-1 H-lndol-3-yl)ethoxy)benzolc acid Step 1: The compound was prepared from the Intermediate from Example 100 step 1 and 1-acetyfpiperazine 4-methyfpfperidfne according to the procedure in Example 100 step 2. The product was purified by the flash column with 50 - 60 % EtOAc/hexane in 87 % yield. Step2: The ester intermediate was hydrofyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 91 % yield, m/z (M-1)712.3. Example 246: 4-2-{1-benzhydryl-5-chloro-2-(2-({r2-(3-niethylplperidin-1- y1)-hyf]sulfonyf}amino)ethyl]-1H-indol-3-yl}ethoxy)benzolc acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and 3-methyfpfperidioe according to the procedure in Example 100 step 2.The product was purified by the flash column with 50-60 % EtOAc/hexane in 94 % yield. Step2: The ester intermediate was hydroJyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 87 % yield. HRMS calc for [C40H37CIN2O4S2 + H] 714.2763 found 714.2765. Example 247: 4-{2-(1-enzhydryl-2-{2-C2-(2-cerbamoyl-pyrrolidin-1-yl)- etHanesurtbnylemino]-emyl}-5-hloro-1H-ndoJ-3-yl)-ethoxy]-benzolc acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and L-prolinamide according to the procedure hi Example 100 step 2. The product was purified by the flash column with EtOAc in 86 % yield. Step2: The ester intermediate was hydrofyzed according to Stop 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid In 43 % yield after preparative HPLC purification. HRMS calc for [C40H37CIN2O4S2 + H] 729.2508 found 729.251. Example 248: 4-[2-(1-benzhydryl-5-chloro-2-{2-I({2-(2S)-2. (methoxymethyl)pyiTolidin-1-y1]ethyl}sulfony1)amino]ethyl}-1H-indol-3- yl)ethoxy]benzoic acid Step 1: The compound was prepared from the intermediate Example 100 step 1 and (SH+)-2-(niethoxymethyl)pyrrolidine according to the procedure Example 100 step 2. The product was purified by the flash column with 80% EtOAc/hexane hi 87 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1. except tHat the pH was adjusted to 4-5, to afford the title acid in 87 % yield. HRMS calcfor [C40H37CIN2O4S2 + H] 730.2712 found 730.2709. Example 249: 4-(2-{1-benzhydryl-5-chloro-2-C2-({I2-(2-ethylplperidin-1- yl)ethyl]aulfonyl)ajnlno)ethyl]-1M- acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and 2-ethylpiperidine according to the procedure in Example 100 step 2. The product was purified by the flash column with 50-60% EtOAc/hexane in 73 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 38 % yield after preparative HPLC purification. HRMS calc for [C40H37CIN2O4S2 + H] 728.292 found 728.2925. Example 250: 4-{2-(1-bonzhydryl-5-chlofO-2-{2-C({2-{(3R,5S)-,5- dimethylmorpholin-4-y1]ethyl}sulforiy1)amino]ethyl}-1H-lndo4-3- yf)ethoxy]benzoic acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and cis-2,6-dimethytmorpholine according to the procedure Example 100 step 2. The product was purified by the flash column with 50% EtOAc/hexane in 79 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5. to afford the title acid in 94 % yield, m/z (M-1) 729.4 Example 251:4-2-{1-beruhydryl-5-chloro-2-[2-({[2-(2-©xa-5- . azablcyclo[2.2.1]hept-5-l)othyl]»ulfonyl}ainino)ethyll-1H-lndol-3- yl]*thoxy)benzolc acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and (1S, 4SH+)-2-a2a-5-oxabicyclo-{2.2.1]-heptane hydrochloride according to the procedure in Example 100 step 2. The product was purified on the CombiFlash with 1-7% MeOH/CtfeCfe in 85 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 100 % yield. HRMS calc fot [C40H37CIN2O4S2 + H] 714.2399 found 714.2397. Example 252: 4-(2-{1-benzhydryl-6-chloro-2-{2-({I2-[2- isopropylpyrrolidin-1-yl)ethyfJsulfonyl}amino)ethyfJ-1H-indol-3- y1}ethoxy)benzoic acid Step 1: The compound was prepared from the intermediate from Example 100 step 1 and 2-(methylethyl}-pyrrolidine hydrochloride according to the procedure Example 100 step 2. The product was purified on the CombiFlash with 1-5% MeOH/CHjCfe in 61 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 97 % yield. HRMS calc for [C40H37CIN2O4S2 + H] 728.292 found 728.293. Example 253: 4-2-(1-benzhydryl-6-chlon)-2-[2-({[2-(2(methyl-3- oxopiDerazin-1-yl)ethyl]sulfonylf)yl}amlr»o)ethyl]-1 H-lndol-3-y1}etttoxy)benzoic acid Step 1: The compound was prepared from the intermediate from from Example 100 step 1 and 3-methyl-2-piperazinone according to the procedure in Example 100 step 2. The product was purified by the flash column with 5% MeOH/CHzCfe in 80 % yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1, except tHat the pH was adjusted to 4-5, to afford the title acid in 29 % yield after preparative HPLC purification. HRMS calc for [C40H37CIN2O4S2 + H] 729.2508 found 729.2501. Example 254: 4-{3-{1J)enzhydryI-5-chloro-2-(2-{[(2- chlorophenyl)sulfonyI]amino}ethyl)-1H-lndol-3-yapropy1}benzolc acid Step 1: To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro- 1H-indol-3-yl]propyl}benzoate (Step 6, Example 1) was acided 2- chtorobenzenesulfonyl chloride according to the procedure in Example 1, Step 7 to generate the product in 66% yield. *H NMR (400 MHz, CDCIj) 5 ppm 1.94 (m, 2 H), 2.74 (m, 6 H), 2.97 (m, 2 H), 3.91 (s, 3 H), 4.94 (t, J=36.32 Hz, 1 H), 6.48 (d, J=9.09 Hz, 1 H), 6.79 (dd, J=8.84, 2.02 Hz, 1 H), 6.83 (6,1 H). 7.03 (m, 4 H), 7.26 (m, 9 H), 7.39 (d, )2.02 Hz, 1 H), 7.44 (d, J=3=3.54 Hz, 2 H), 7.90 (d. -7.58 Hz, 1 H), 7.96 (d, -=8.34 Hz, 2 H) Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford, after flash chromatography, the title acid in 84% yield. 1H NMR (400 MHz, CDCIj) 8 ppm 1.96 (m, 2 H), 2.76 (m, 6 H), 2.98 (m, 2 H), 5.00 (t, J=6.32 Hz, 1 H), 6.79 (dd, J=8.84,2.02 Hz, 1 H), 6.84 (s, 1 H), 7.04 (m, 4 H). 7.28 (m, 10 H), 7.40 (d. J=1.77 Hz, 1 H), 7.45 (d, J=3.79 Hz, 2 H), 7.90 (d, -=7.58 Hz, 1 H). 8.02 (d. )8.34 Hz, 2 H). HRMS calc for C39H34Cl2o4S Na, 719.1514; found (ESI-), 695.15363 Example 265:4-{2-{1-benzhydryl-e-chloro-2-2-{I(2- chlorophem/l)sulfonyfJamino}ethyl)-1--indol-3-yl]ethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-{2-(2- aminoethylM-nzhydryl-5-l()ro-1H- indol-3-yl-]ethyl]betizoic-and 2 chlorobenzenesutfonyl chloride according to the procedure in Example 1, Step 7 in 86% yield. *H NMR (400 MHz, DMSO-D6) 6 ppm 2.93 (m, 2 H), 3.02 (m. 2 H), 3.11 (t, .7=6.57 Hz, 2 H), 3.81 (s, 3 H), 4.19 (t, -=6.57 Hz, 2 H), 6.49 (d, -=8.84 Hz, 1 H), 6.80 (dd. J=8.84. 2.02 Hz, 1 H), 6.96 (d, J=8.84 Hz, 2 H), 7.01 (s, 1 H), 7.04 (dd, J=6.95, 2.40 Hz, 4 H), 7.34 (m, 5 H), 7.40 (m, 1 H), 7.60 (m, 3 H), 7.80 (dd, J=7.83, 1.52 Hz. 1 H), 7.86 (d, J=8.84 Hz, 2 H), 8.11 (t, J=5.81 Hz, 1 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1. The crude material was purified via flash chromatography to afford the title acid in 74% yield. 'H NMR (400 MHz, CDCIs) 6 ppm 2.89 (m. 2 H), 3.18 (t -6.57 Hz, 2 H), 4.20 (t, J=6.57 Hz, 2 H), 5.09 (t .1*6.32 Hz, 1 H), 6.53 (d, J=8.84 Hz, 1 H), 6.82 (m, 3 H), 6.90 (s, 1 H), 7.05 (m, 4 H), 7.26 (m, 7 H), 7.45 (m, 2 H), 7.52 (d, -=2.02 Hz, 1 H). 7.90 (m, 1 H), 8.00 (d, J=8.84 Hz. 2 H). HRMS calc for C38H32Cl2N2O5S. 698.1409; found (ESI+), 699.14786. Anal. Calcd for C38H32Cl2N2C5S: C. 65.23; H, 4.61; N. 4.00. Found: C, 65.02; H, 4.44; N, 3.94. Example 256:4-((2-[1-benzhydry1-5-chloro-2-(2-{[(2- chlorophenyl)sulfonyl]amino)ethyl)-1 /MndcJ-3-yl]ethyl}sulfonyl)benzoic acid Step 1: This compound was prepared from 4-{2-{2-(2-amino-ethyl)-1- benzhydiyl-5-loro-1H-indol-3-yl]etrenesulfonyl]-benzoic acid methyl ester and 2- chlorosulfonyl chloride according to the procedure in Example 1, Step 7 in 48% yield. 1H NMR (400 MHz, CDCI) 5 ppm 2.88 (q, -=7.07 Hz, 2 H), 3.03 (t. J*7.33 Hz, 2 H), 3.20 (m, 2 H), 3.43 (m, 2 H), 3.97 (s, 3 H), 5.18 (t, J=6.44 Hz. 1 H), 6.46 (d, .7=8.84 Hz, 1 H), 6.78 (dd, J=8.97, 2.15 Hz, 1 H), 6.84 (s, 1 H), 7.04 (dd, J=6.69,2.40 Hz, 4 H), 7.21 (d, J=2.02 Hz, 1 H), 7.31 (m, 7 H). 7.48 (d. -3.79 Hz, 2 H), 7.91 (d, )7.58 Hz. 1 H), 8.08 (d, -=8.59 Hz, 2 H), 8.24 (m, 2 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 97% yield. 1H NMR (400 MHz. CDCI,) 5 ppm 2.88 (q, -=6.91 Hz, 2 H), 3.04 (t, -=7.20 Hz, 2 H), 3.22 (m, 2 H), 3.45 (m, 2 H), 5.25 (t -=6.44 Hz, 1 H), 6.47 (d, J=9.09 Hz, 1 H), 6.78 (dd. )8.84,2.02 Hz, 1 H), 6.84 (s, 1 H), 7.04 (dd, J=6.57,2.53 Hz, 4 H). 7.22 (d, J*2.02 Hz, 1 H), 7.31 (m, 7 H), 7.48 (d, .7=3.79 Hz, 2 H), 7.92 (d. -=7.83 Hz, 1 H), 8.12 (d, J=8.S9 Hz, 2 H), 8.28 (d, J=8.34 HZ.2H). Example 257: 4-H1-*)enzhydryl-6H:hk)ro-2-2-1?2-lniethyl-1/eini(lazol-4. yl)sulfonyl]amino}ethyl)-1--indol-3-y1]propyt}benzoec acid Step 1: To the methyl 4H2--2-amirx)ethyl)1-benzhydryl-5-lorc)-1H4ndol- 3-yl]propyl]benzoate was acided 1,2-dimethylimidazote-4-sutfonyl chloride according to the procedure in Example 1, Step 7 to generate the product in 80% yield. 1H NMR (400 MHz, DMSO-D6) 5ppm 1.86 (m, 2 H), 2.18 (s, 3 H), 2.71 (m, 4 H), 2.94 (m, 4 H), 3.49 (s, 3 H), 3.83 (s, 3 H), 6.42 (d, J=8.84 Hz, 1 H), 6.76 (dd, .7=8.84,2.02 Hz, 1 H), 7.06 (m. 4 H), 7.36 (m, 8 H). 7.44 (d, -=2.02 Hz, 1 H), 7.49 (s, 1 H). 7.59 (s, 1 H), 7.87(d,j=8.08Hz,2H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 61% yield. 1H NMR (400 MHz, DMSO-D6) 6 ppm 1.87 (m, 2 H), 2.18 (s, 3 H), 2.70 (t, -7.58 Hz, 4 H), 2.95 (m, 4 H), 3.49 (s, 3 H), 6.42 (d, J=8.84 Hz, 1 H), 6.76 (dd. J=8.S4, 2.02 Hz, 1 H), 7.06 (m, 5 H). 7.35 (m, 8 H), 7.44 (d, -2.02 Hz, 1 H). 7.49 (s. 1 H), 7.59 (t, -=4.93 Hz, 1 H), 7.85 (d, J=8.34 Hz, 2 H). HRMS: caicd for C38H37CIN2O4S, 680.2224; found (ESI+), 681.22879 Example 258: 4-{2-[1-benzhydryl-5-chlon)-2-(2-{[(1(2-dimethyl-1H-4inldazol-4- yl)sulfbnyl]amino)ethyl)-1H-indol-3-yl]ethoxy)benzoicacid Step 1: This compound was prepared from methyl 4-{2-{2-(2- aminoethyl)-1-benzhydryl-5-chtoro-11H-indol-3-yl]ethoxy}benzoate and 1,2- dimethylimidazole-4-sulfonyl chloride according to the procedure in Example 1, Step 7 in 84% yield. 1H NMR (400 MHz, CDCts) 6 ppm 2.25 (s, 3 H), 3.07 (m, 2 H), 3.13 (m, 2 H), 3.18 (t, -=6.82 Hz, 2 H), 3.39 (s, 3 H). 3.88 (s, 3 H), 4.17 (t, J=6.69 Hz, 2 H), 5.30 (m, J=2.78 Hz, 1 H), 6.47 (d, J*9.09 Hz, 1 H), 6.79 (dd, J=8.B4,2.02 Hz, 1 H), 6.83 (d, J=8.84 Hz, 2 H), 6.93 (s, 1 H), 7.08 (m, 5 H), 7.29 (m, 6 H), 7.51 (d, -=2.02 Hz, 1 H), 7.94 (d, J*8.84 Hz, 2 H). Step 2: The ester intermediate was hydroiyzed according to Step 8, Example 1 to afford the title acid in 55% yield. 1H NMR (400 MHz, DMSO-D6) 5 ppm 2.17 (s. 3 H), 3.02 (m. -=9.10 Hz, 4 H), 3.14 (t, J*6.57 Hz, 2 H), 3.47 (s, 3 H), 4.21 (t, -=6.69 Hz, 2 H), 6.47 (d, J=8.64 Hz, 1 H). 6.79 (dd, J=8.&4, 2.27 Hz, 1 H), 6.96 (d, J-8.84 Hz, 2 H), 7.07 (m, 5 H), 7.36 (m, 6 H), 7.49 (s, 1 H), 7.63 (m. 2 H), 7.84 (d. J=B.&4 Hz, 2 H). HRMS: calcd. for C37H35CIN4O6S, 682.2017; found (ESI+), 683.20812. Example 269: 3-[4-({2-{1-benzhydiyl-6(hloro-2-(2-{n2- chlorophenyl)eulfonyl]emino)ethyl)-1H-»rtdol-3- yl]ethyl}surfbnyl)phenyl]propanoic acid Step 1: This compound was prepared from 3-(4-{242-{2-Amino-ethyl)- 1-benzhydryl-5-cryl]ro-1Wndo(-3-y0-tHanesutfonyi}-phe- acid ethyl ester and 2-chlorosulfonyl chloride according to the procedure in Example 1, Step 7 in 78% yield. 1H NMR (400 MHz, CDCI*) 6 ppm 1.25 (m, 3 H). 2.66 (t -7.58 Hz, 2 H). 2.88 (q, -=6.48 Hz, 2 H), 3.07 (m, 6 H), 3.34 (m, 2 H), 4.12 (q, 7=7.07 Hz, 2 H), 5.31 (t. J=6.Z2 Hz, 1 H), 6.45 (d, J=8.84 Hz, 1 H), 6.77 (dd, 7=8.84. 2.02 Hz, 1 H), 6.85 (s, 1 H), 7.04 (m, 4 H), 7.16 (d, )1.77 Hz, 1 H), 7.30 (m, 7 H), 7.46 (m, 4 H), 7.91 (m, 3 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford, after flash chromatography, the title acid in 41% yield. 1H NMR (400 MHz, CDCI3) 6 ppm 2.74 (s, 4 H), 2.86 (t -6.69 Hz, 2 H), 2.93 (m, 2 H), 3.08 (t, .A=6.57 Hz, 2 H), 3.29 (m, 2 H), 6.43 (d, J=8.84 Hz, 1 H), 6.61 (s, 1 H), 6.78 (m, 2 H), 7.00 (m. 4 H), 7.25 (m, 7 H), 7.36 (d, J=1.77 Hz. 1 H), 7.45 (m, 2 H). 7.50 (d, J=8.34 Hz, 2 H), 7.80 (d, -7.58 Hz, 1 H), 7.93 (d, )8.34 Hz. 2 H). HRMS: calcd. for C4oH36CI2N2O6S2(M-H) 773.1319 found 773.13107. Example 260: 4K2-{1-benzhydryl-5-chloro-2-(2-{[(3-chloro-4- methytpheny1)sulfonyl]ainino}ethyl)-1H-indol-3(yl]ethoxy}benzoicacid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl]ethoxy)benzoate and 3-chloro-4- methytbenzenesulfonyl chloride according to the procedure in Example 1, Step 7 in 100% yield. 1H NMR (400 MHz, CDCI2) 8 ppm 2.38 (s. 3 H), 2.92 (q, J=6.99 Hz, 2 H), 3.09 (t, J=7.58 Hz, 2 H), 3.18 (t. J=6.44 Hz, 2 H), 3.88 (s, 3 H), 4.21 (t, J=6A4 Hz, 2 H), 4.42 (t, -=644 Hz, 1 H). 6.54 (d, J=8.84 Hz, 1 H), 6.79(m, 2 H), 6.83(dd. J=8.84, 2.02 Hz, 1 H), 6.88 (s, 1 H), 7.04 (m, 4 H), 7.20 (d, J=8.08 Hz, 1 H), 7.29 (m. 6 H), 7.40 (dd, J=7.96, 1.89 Hz, 1 H), 7.52 (d, J=2.02 Hz. 1 H), 7.66 (d. -=1.77 Hz. 1 H), 7.93 (m, 2 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1. The crude product was purified using flash chromatography to afford the title acid in 69% yield. 1H NMR (400 MHz, CDC13) 8 ppm 2.38 (s. 3 H), 2.93 (m, 2 H), 3.10 (t, J*7.45 Hz, 2 H), 3.19 (t, J*6.44 Hz. 2 H), 4.23 (t, J=6.44 Hz, 2 H), 4.52 (s, 1 H), 6.54 (d, J=B.84 Hz, 1 H), 6.83 (m, 3 H). 6.89 (s, 1 H), 7.04 (m, 4 H), 7.20 (d, J-8.08 Hz, 1 H), 7.29 (m, 6 H), 7.40 (dd, J=8.O8t 1.77 Hz, 1 H). 7.53 (d, J-2.02 Hz, 1 H), 7.67 (d, J=2.02 Hz, 1 H), 7.98 (d, J=8.84 Hz, 2 H). HRMS: calcd. for C39H34CI2N2O5S, 712.1565; found (ESI+). 713.16268. Anal. Calcd for C39H34CI2N2O5S C, 65.64; H, 4.80; N. 3.93. Found: C. 65.62; H, 4.52; N, 3.73. Example 261: 4-{H1-bonzhydryI-5-chloro-2-(2-{I(3-chloro-4- methylpheny1)sulfonyl]anUno}ethyl)-1 M4ndol-3-yl]propyl}benzoic acid Step 1: To the methyl 4-{2-[2-(2-aminoethyl)-1-t)enzhydryl-5-chloro- 1/-H'ndol-3-yl]propyl}benzoate was acided 3-chloro-4-methytbenzenesulfonyf chloride according to the procedure in Example 1, Step 7 to generate the product in 98% yield. 1H NMR (400 MHz, CDCfe) 6 ppm 1.95 (m, 2 H), 2.40 (s, 3 H), 2.72 (q, J=8.25 Hz, 4 H). 2.82 (q, 7=6.74 Hz, 2 H), 2.96 (t, J=7.33 Hz. 2 H), 3.91 (s, 3 H), 4.27 (t, J=6.44 Hz, 1 H), 6.49 (d, J=8.84 Hz, 1 H), 6.80 (dd, 7=8.97,2.15 Hz, 1 H), 6.82 (s, 1 H), 7.02 (m. 4 H), 7.26 (m, 9 H), 7.38 (dd, 7=7.96,1.89 Hz, 1 H), 7.40 (d, 7=2.02 Hz, 1 H), 7.66 (d, 7=1.77 Hz, 1 H), 7.96 (d, 7=8.34 Hz, 2 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford, after flash chromatography, the title acid in 40% yield. *H NMR (400 MHz, CDCI,) 5 ppm 1.96 (m, 2 H), 2.40 (s, 3 H), 2.73 (m, 4 H), 2.83 (m, 2 H), 2.98 (t, 7=7.33 Hz, 2 H), 4.33 (t, 7=6.32 Hz, 1 H). 6.49 (d, 7=8.84 Hz, 1 H). 6.80 (dd. 7=8.84, 2.27 Hz, 1 H), 6.83 (s, 1 H), 7.02 (m. 4 H), 7.21 (d, 7=7.83 Hz, 1 H). 7.29 (m, 8 H), 7.39 (m, 2 H),7.66 (d, 7=1.77 Hz, 1 H), 8.00 (d, 7=8.08 Hz, 2 H). HMRS: calcd. for C39H34CI2N2O5S 710.1773; found (ESI+), 711.18411. Anal. Calcd for C39H34CI2N2O5S. C. 67.51; H, 5.10; N, 3.94. Found: C, 67.67; H, 5.27; N, 3.81. Example 262:4-{2-{1-benzhydryl-5-chloro-2-(2-I(3-chloro-5-fIuoro-2- methylpHanyl)sulfonyl]aniino}ethylH--indol-3-yl]ethoxy}benzoicacid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- berizhydryl-5(hloro-11HrKk)l-3-yl]ethoxy}benzoate and 3-chloro-5-fluoro-2- methylbenzenesulfonyl chloride according to the procedure in Example 1, Step 7 in 100% yield. 1H NMR (400 MHz, CDCI,) 5 ppm Z26 (s, 3 H), 2.99 (m, 2 H), 3.10 (m, 2 H). 3.18 (t, 7=6.57 Hz, 2 H), 3.88 (s, 3 H), 4.21 (t, 7=6.57 Hz, 2 H), 4.71 (t, 7=6.32 Hz, 1 H), 6.52 (d, 7=8.84 Hz, 1 H), 6.81 (m, 3 H), 6.88 (s. 1 H), 7.04 (m, 4 H), 7.14 (d, J*9.60 Hz. 1 H), 7.29 (m, 6 H), 7.52 (d. 7=2.02 Hz, 1 H), 7.58 (d. 7=7.58 Hz, 1 H), 7.94 (m, 2 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 69% yield. 'H NMR (400 MHz, CDCI3) 5 ppm Z26 (s, 3 H), 2.99 (m, 2 H), 3.11 (m, 2 H), 3.19 (t, 7=6.44 Hz, 2 H), 4.23 (t, 7=6.44 Hz, 2 H), 4.79 (t, 7=6.32 Hz, 1 H), 6.52 (d, 7=8.84 Hz, 1 H), 6.83 (m, 3 H). 6.88 (s, 1 H), 7.04 (m, 4 H). 7.15 (d, 7=9.60 Hz, 1 H). 7.29 (m. 6 H), 7.52 (d. 7=2.02 Hz. 1 H), 7.59 (d, 7=7.58 Hz, 1 H), 7.99 (d, 7=8.84 Hz, 2 H). HRMS: calcd. for C39H34CI2N2O5S, 730.1471; found (ESI+). 731.1532. Example 263:4-{3-{1-benzhydryJ-6-chloro-2-(2-{K3-chloro-5-fliioro-2- nrittthylpheny])sulfonyl]amlno}6thyl)-1H-indol-3-yl]propyl}benzolcacid Step 1: To the methyl 4-{2-{2-(2-aminoethyl)-1-ben2hydryl-5-chloro-1 Wndol- 3-yl]propyl}benzoate acided and 3-chloro-5-fluoro-2-methylbenzenesutfonyl chloride according to the procedure in Example 1, Step 7 to generate the product in 75% yield. 'H NMR (400 MHz, CDCIj) 6 ppm 1.95 (m, 2 H), 2.27 (s, 3 H), 2.72 (q, 7*7.58 Hz, 4 H). 2.89 (t, 7=6.82 Hz, 2 H), 2.97 (m, 2 H), 3.91 (8,3 H), 4.59 (t, J-6.19 Hz, 1 H), 6.47 (d, 7=8.84 Hz, 1 H), 6.80 (dd, 7=8.97,2.15 Hz, 1 H), 6.82 (8,1 H), 7.03 (dd, 7=6.82.2.53 Hz, 4 H), 7.13 (d, 7=9.60 Hz, 1 H), 7.24 (d, 7=8.34 Hz, 2 H), 7.29 (m, 6 H), 7.40 (d, 7=2.02 Hz, 1 H) 7.58 (d, 7=7.58 Hz, 1 H), 7.96 (d, 7=8.34 Hz, 2 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 96% yield. 1H NMR (400 MHz, CDCI3) 6 ppm 1.96 (m, 2 H), 2.28 (s, 3 H), 2.74 (m, 4 H), 2.89 (m, 2 H), 2.99 (m, 2 H), 4.65 (q. 7=6.32 Hz, 1 H), 6.47 (d, 7=8.84 Hz, 1 H). 6.80 (dd. 7=8.97,2.15 Hz, 1 H). 6.82 (s, 1 H). 7.03 (m, 4 H), 7.14 (d, 7=9.60 Hz, 1 H), 7.30 (m, 8 H), 7.40 (d, 7=2.02 Hz, 1 H). 7.58 (d, 7=7.58 Hz, 1 H), 8.01 (d, 7=8.08 Hz, 2 H) HMRS: calcd. for C39H34CI2N2O5S 728.1679; found (ESI+), 729.17441. Anal. Calcd for C39H34CI2N2O5S C, 65.84; H, 4.83; N, 3.84. Found: C, 65.49;, H, 5.02; N, 3.72. Example 264: 4-{3-{1-benzhydryl-5-chloro-2-2-a(2- nltn)phenyl)sulfonyfJamlno)ethyl)-1H- IndoW-yl]propyl]benzolc acid Step 1: To the methyl 4---2-aminoethyl)1-benzhydryJ-5-chk)ro-1H-indo»- 3-yl]propyl]benzoate (Step 6, Example 1) was acided and 2-nttrobenzenesutfonyl cNoride according to the procedure in Example 1, Step 7 to generate the product in 74% yield. 1H NMR (400 MHz, CDC!,) 5 ppm 1.97 (m. 2 H), 2.73 (q, 7=8.08 Hz, 4 H), 2.91 (m, 2 H), 3.04 (m. 2 H), 3.91 (8, 3 H), 5.33 (t, 7=6.06 Hz, 1 H), 6.52 (d. 7=8.84 Hz, 1 H). 6.80 (dd, 7=8.84, 2.02 Hz. 1 H). 6.90 (s, 1 H), 7.06 (dd, 7=6.57, 2.53 Hz. 4 H), 7.24 (d. 7*8.34 Hz, 2 H), 7.29 (m, 6 H), 7.39 (d. 7*2.02 Hz, 1 H), 7.50 (td, 7=7.71, 1.26 Hz. 1 H), 7.65 (td. 7*7.77, 1.39 Hz, 1 H), 7.75 (dd, 7*7.83, 1.26 Hz. 1 H), 7.80 (dd, 7=7.96,1.14 Hz, 1 H). 7.96 (d. 7=8.08 Hz, 2 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 100% yield. 1H NMR (400 MHz, CDCIj) 6 ppm 1.98 (m, 2 H), 2.75 (m, 4 H), 2.92 (m, 2 H), 3.06 (m, 2 H), 5.35 (t, 7=6.06 Hz, 1 H), 6.52 (d, 7=8,84 Hz, 1 H), 6.81 (dd, -=8.84,2.02 Hz, 1 H), 6.91 (s, 1 H), 7.07 (dd, 7=6.82,2.53 Hz, 4 H). 7.29 (m, 8 H), 7.40 (d, -2.02 Hz, 1 H), 7.51 (m, 1 H), 7.66 (m, 1 H), 7.76 (dd, J=7.83,1.26 Hz, 1 H), 7.81 (dd, J=7.96,1.14 Hz, 1 H), 6.01 (d, J=8.34 Hz, 2 H) HMRS: calcdforC39H34CI2N2O5S 707.18568; found (ESI+), 708.19296. Example 265: 4-(2-[1-benzhydry1-5-chloro-2-(2-n(2- nrtrophenyl)eulfonyl]amlno)othyl)-1H-lndol-3-yI)ethoxy)benzolc acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-chJoro-1W-lndol-3-yllethoxy}benzoate and 2-nitrosulfonyl chloride according to the procedure in Example 1, Step 7 in 63% yield. *H NMR (400 MHz, COCIa) 5 ppm 2.99 (m, 2 H), 3.19 (m. 4 H), 3.88 (s, 3 H). 4.21 (t, J-.57 Hz, 2 H), 5.40 (t, J=6.19 Hz. 1 H), 6.57 (d, J=8.84 Hz, 1 H), 6.82 (m, 3 H), 6.96 (s, 1 H). 7.08 (m, 4 H), 7.29 (m, 6 H), 7.49 (Id, )7.71,1.26 Hz. 1 H). 7.52 (d, -1.77 Hz, 1 H), 7.65 (td, )7.71,1.26 Hz, 1 H), 7.80 (m, 2 H), 7.93 (d, 2 H). Step 2: The ester Intermediate was hydroryzed according to Step 8,Example 1 to afford the title acid in 90% yield. 1H NMR (400 MHz, CDCI3) 5 ppm 2.99 (m, 2 H), 3.20 (m, 4 H), 4.23 (t, 7=6.57 Hz, 2 H), 5.40 (t, )&1» Hz. 1 H), 6.57 (d, 7=8.84 Hz, 1 H), 6.84 (m, 3 H), 6.95 (s, 1 H), 7.08 (m, 7=5.68, 3.66 Hz, 4 H), 7.29 (m, 6 H), 7.50 (m. 2 H), 7.65 (td. 7=7.77, 1.39 Hz, 1 H). 7.80 (m. 2 H), 7.98 (d. 2 H). HRMS: calcd for C39H34CI2N2O5S 709.16495; found (ESI+), 710.17059. Example 266: 4-(2-(1-benzhydryi-5-chlorx)-2-{2-I(meeityleulfony1)emino] ethyl]-1/Mndol-3-yl)ethoxy]benzolc acid Step 1: This compound was prepared from methyl 4-(2-(2-(2-aminoethyl)-1- benzhydryl-5-chloro-1W4nd()l-3-yf]ethoxy}benzoate and 2-mestitytenesurfonyl chloride according to the procedure in Example 1, Step 7 in 89% yield. 1H NMR (400 MHz, CDCI3) 5 ppm 2.24 (s, 3 H), 2.48 (s, 6 H), 2.90 (m. 2 H), 3.05 (m, 2 H), 3.16 (t. J*6.69 Hz, 2 H). 3.89 (s. 3 H). 4.17 (t, J=6.69 Hz, 2 H), 4.48 (t, J=6.44 Hz. 1 H), 6.52 (d, 7=8.84 Hz, 1 H) Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 68% yield. 'H NMR (400 MHz, CDCIs) 6 ppm 2.24 (s, 3 H), 2.48 (s. 6 H), 2.90 (q, -6.99 Hz, 2 H), 3.06 (m. 2 H). 3.17 (t, J=6.69 Hz, 2 H), 4.19 (t. J=Gr67 Hz, 2 H), 4.59 (s, 1 H), 6.52 (d, J=8.B4 Hz. 1 H), 6.82 (m, 6 H), 7.02 (m, 4 H), 7.29 (m, 6 H), 7.52 (d, J=2.02 Hz, 1 H), 7.98 (d, J=B.S4 Hz, 2 H). HRMS: calcd. for C39H34CI2N2O5S 706.22682; found (ESI+), 707.23370. Example 267: 4-(3-(1-BenzhydryI-6-chloe)-2-{2-(2,4,64rimethyl- benzenesulfonytaniino)-ethyl]-1H-indo(-3)y(H)ropyl)-benzoicacid Step 1: To the methyl 4-2-{2-(2-aminoethyl)-1-benzhydryl-5-chloro-1/-indol- 3-yl]propyl]benzoate (Step 6, Example 1) was acided 2-mesitylenebenzenesutfonyl chloride according to the procedure in Example 1, Step 7 to generate the product in 83% yield. 1H NMR (400 MHz, CHLOROF CDO,) S ppm 1.93 (m, 2 H), 2.26 (s, 3 H). 2.47 (s. 6 H), 2.70 (m, 4 H), 2.82 (m, 2 H), 2.91 (m, 2 H), 3.91 (s, 3 H), 4.36 (t, )6.44 Hz. 1 H). 6.46 (d. J=38.84 Hz. 1 H), 6.75 (8,1 H), 6.79 (dd, J=B.&4, 2.27 Hz, 1 H), 6.88 (8,2 H). 7.00 (m, 4 H). 7.22 (d, -=8.34 Hz, 2 H), 7.28 (m. 6 H), 7.39 (d, J=2.02 Hz, 1 H). 7.95 (d, J=8.34 Hz, 2 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1toafford the title acid in 84% yield.1HNMR(400MHz,CDa3)6ppni1.94(mI2H), 2.26 (8, 3 H), 2.47 (s. 6 H), 2.71 (m, 4 H), 2.83 (m, 2 H), 2.93 (m. 2 H), 4.45 (t J=5.81 Hz, 1 H), 6.46 (d, J=8.84 Hz, 1 H), 6.75 (s. 1 H), 6.79 (dd. J=8.97.2.15 Hz. 1 H), 6.88 (s. 2 H), 7.00(m,4H), 7.27(m, 8 H). 7.40(d, J=2.02Hz. 1 H). 8.01 (d, J=834Hz, 2 H). HMRS: calcd. for C39H34CI2N2O5S 704.24756; found (ESI+), 705.25452. Example 268: 4-(3-{1-beftthydryl-6-chloro-2-2-({I2-fluoro-€- (trMuofomethyl)phenyl]sulfonyl}amino-)1H-indol-3-yl}benzioc acid Step 1: 24Korno-1*fluoro-3-rifhx)romethylbenze4ie (1.0 eq.) was taken up in tetrahydrofuran (0.5 M) and dethyl ether (0.5 M) and cooled to -78°C. nbutylilthium (2.5M, 1.0 eq.) was acided dropwise and the reaction stirred for 40 minutes. A volume of sulfur dioxide equal to the volume of THF was condensed and diluted with two volumes of ether. The lithium salt of the benzene was canulated into the sulfur dioxide and the reaction was allowed to slowly warm to room temperature. The solvent was removed and the resulting salt was washed with ether then taken up in hexanes (1.0M) and cooled in and ice bath. Sulfuryl chloride (1.06 eq.) was acided and the reaction warmed to room temperature and stirred for 5 hours. The solvent was removed to give 2-fluoro-6-trifluoromethylbenznesulfonyl chloride as a white, oily solid in 65 % yield. The product was used crude. 1H NMR (400 MHz, DMSO-D6) D ppm 7.46 (m, 1 H), 7.52 (m, 2 H). Step 2: To methyl 4-{2-{2-(2-amlnoethyl)-1-benzhydryl-5-hloro-1H-indol-3- yrjpropyl]benzoate was acided 2-fluoro-6-trifluoromethylbenzenesutfonyl chloride according to the procedure in Example 1, Step 7 to generate the product in 62% yield. 1H NMR (400 MHz, CDCI,) 6 ppm 1.94 (m, 2 H), 2.73 (m. 4 H), 2.91 (m, 2 H), 2.99 (m, 2 H), 3.91 (s, 3 H), 4.87 (t, Je5.81 Hz, 1 H), 6.50 (d, J=8.84 Hz, 1 H), 6.81 (dd. J*8.97, 2.15 Hz, 2 H), 7.03 (m, 4 H), 7.24 (d, J*8.34 Hz, 2 H), 7.30 (m, 7 H), 7.41 (d, J-2.02 Hz, 1 H), 7.62 (m, 2 H), 7.95 (d, Je8.34 Hz, 2 H). Step 3: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 56% yield. 1H NMR (400 MHz, CDCI,) 5 ppm 1.96 (m, 2 H), 2.75 (m. 4 H), 2.92 (m, 2 H), 3.00 (m, 2 H), 4.93 (t, J-5.94 Hz, 1 H), 6.51 (d, J=8.84 Hz, 1 H), 6.82 (m, 2 H), 7.03 (m, 4 H), 7.28 (m. 8 H), 7.32 (d, Je10.61 Hz, 1 H), 7.41 (d, J=2.02 Hz, 1 H.) 7.63 (m, 2 H), 8.01 (d, J=8.08 Hz, 2 H). HRMS calc for [C39H34CI2N2O5S+ H] 749.18585 found 749.18578. Example 269: 4-(2-{1-benzhydryl-5(hloro-2-C2-({I2-fluoro-6- (ti1fluorornethyl)phenyl]sutfonyl}amino)ethyl]-1H-lndol-3-yl}ethoxy)benzoic acid Step 1: To methyl 4-2-2-[2-aminoethyf)-1-nzhydryl-5-chloro-1H-inck)l-3- yl]ethoxy}benzoate was acided 2-fluoro-6-trlfluoromethy(benzenesutfonyl chloride according to the procedure in Example 1, Step 7 to afford product in 89% yield. 1H NMR (400 MHz, CDCI3) S ppm 3.00 (m. 2 H), 3.12 (m, 2 H), 3.20 (t, J=6.44 Hz, 2 H), 3.88 (s, 3 H), 4.20 (t, J=6.44 Hz, 2 H), 4.99 (t, J=6.06 Hz, 1 H), 6.54 (d, J=8.84 Hz, 1 H), 6.79 (d, J=8.84 Hz, 2 H), 6.84 (dd, J=8.97,2.15 Hz, 1 H), 6.88 (s, 1 H), 7.04 (dd, J=6.82.2.53 Hz, 4 H), 7.28 (m, 6 H), 7.33 (m, 1 H), 7.54 (d, Je2.02 Hz, 1 H). 7.60 (m, 2 H). 7.93 (d, J=9.10 Hz, 2 H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 36% yield. 'H NMR (400 MHz, CDCI,) 5 ppm 3.01 (m, 2 H), 3.13 (m, 2 H), 321 (t. J=644 Hz, 2H), 4.22(t, J=644 Hz, 2 H), 5.07 (t, J=6.06 Hz, 1 H), 6.55 (d, J=8.84 Hz, 1 H), 6.83 (m, 3 H), 6.88 (s, 1 H), 7.04 (m, 4 H), 7.28 (m, 6 H), 7.32 (m, 1 H), 7.55 (d, J=2.02 Hz, 1 H), 7.61 (m, 2 H), 7.98 (d. J=8.84 Hz, 2 H). HRMS calc for [C39H31CIF4N2O5S + H] 751.16511 found 751.16431. Example 270:4-{H1-benzhydryl-5-chloro-2-(2-{[(2,6- dimethylphenyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyI}benzoic acid Step 1: 2,6-Dimethylbenzenesuifonyl chloride was prepared from 2-bromo- 1,3-dimethylbenzene according to the procedure in Example 18, Step 1-2. The reaction gave product as a white solid in 84% yield. 1H NMR (400 MHz, DMSO-D6) 8 ppm 2.54 (s, 6 H), 6.94 (d. J*7.33 Hz, 2 H), 7.02 (m, 1 H). Step 2: To methyl 4-{2-[2-(2-aminoetriyl)-1-benzhydryl-5-chloro-1H-indol-3- yl]propyl}benzoate was acided 2,6-dimethylbenzenesulfonyl chloride according to the procedure in Example 1, Step 7 to generate the product in 66% yield. 1H NMR (400 MHz, CDCI,) 5 ppm 1.93 (m, 2 H), 2.50 (s, 6 H), 2.70 (m, 4 H), 2.82 (m. 2 H), 2.93 (m, 2 H), 3.91 (s, 3 H), 4.40 (t, J=6.32 Hz, 1 H), 6.47 (d, J=8.84 Hz, 1 H), 6.77 (s, 1 H), 6.80 (dd. J=8.97,2.15 Hz. 1 H), 7.00 (m, 4 H). 7.07 (d, J=7.58 Hz, 2 H). 7.22 (d, J=8.08 Hz, 2 H), 7.27 (m, 7 H), 7.40 (d, J=2.02 Hz, 1 H). 7.95 (d, J=8.08 Hz, 2 H). Step 3: The ester intermediate was hydrotyzed according to Step 8, Example 1 to afford the title acid in 96% yield. 1H NMR (400 MHz, DMSO-D6) S ppm 1.81 (m, 2 H.) 2.50 (s, 6 H), 2.65 (m, 4 H), 2.81 (m, 2 H), 2.87 (m, 2 H), 6.45 (d, J=8.84 Hz, 1 H), 6.77 (dd. J=8.84.2.27 Hz, 1 H), 6.94 (s, 1 H). 7.02 (m, 4 H), 7.17 (d, J=7.58 Hz, 2 H), 7.28 (d. Js8.34 Hz, 2 H). 7.33 (m. 6 H). 7.43 (d, J=2.27 Hz, 1 H), 7.70 (t. J=5.81 Hz, 1 H). 7.85 (d, J=808 Hz, 2 H). HRMS calc for [C39H34CI2N2O5S + H] 691.23919 found 691.23872. Example 271:4-{2-{1-benzhydry1-5-chloro-2-(2-{r)(2,6- dimethylphenyl)»urfonyl]amlno}ethyl1H- indol-3-yl]ethoxy}benzoic acid Step 1: To methyl 4-{2-{2-(2-aminoethyl)-1-benzhydry1-5-chloro-1H-Jndol-3- yi]ethoxy}benzoate was acided 2,6-dimethylbenzenesulfonyl chloride (Example 266, Step 1) according to the procedure in Example 1, Step 7 to afford product in 88% yield. 'H NMR (400 MHz, CDCI3) 8 ppm 2.51 (s. 6 H), 2.90 (m, 2 H), 3.06 (m, 2 H), 3.16 (t, Je6.69 Hz, 2 H), 3.89 (s, 3 H), 4.17 (t, J=6.57 Hz, 2 H), 4.50 (t, J=6.19 Hz, 1 H), 6.53 (d, J*8.84 Hz, 1 H). 6.79 (d, J=9.10 Hz, 2 H), 6.83 (m, 2 H), 7.02 (m, 4 H), 7.06 (d. J*7.58 Hz, 2 H), 7.23 (m, 1 H), 7.28 (m, 6 H), 7.53 (d, J=2.02 Hz, 1 H), 7.93 (d,J*8.84Hz,2H). Step 2: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 79% yield. 1H NMR (400 MHz, DMSO-D7) 5 ppm 2.48 (s, 6 H), 2.85 (m, 2 H), 2.95 (m, 2 H),3.08 (t, J=6.57 Hz, 2 H), 4.15 (t, Je6.69 Hz. 2 H), 6.48 (d, J=8.84 Hz. 1 H). 6.79 (dd, J=8.84,1.77 Hz, 1 H), 6.90 (d, J=8.84 Hz, 2 H). 6.95 (s. 1 H), 7.01 (m, 4 H), 7.14 (d, J=7.58 Hz, 2 H), 7.29 (m, 6 H). 7.63 (d, J=2.02 Hz, 1 H). 7.73 (t, J=5.94 Hz. 1 H), 7.82 (d, J=8.84 Hz, 2 H). HRMS calc for . [C4oHS7CIN208S + H] 693.21845 found 693.21791. Example 272:4-{2-[1-benzhydryl-5-chloro-2-(2-{[(2f6- diethylphenyl)sulfonyl]amino)ethylMH- lndoJ-3-yl]ethoxy}benzoic acid Step 1: 2,6-Diethylbenzenesulfonyl chloride was prepared from 2-bromo-1,3- diethybenzne according to the procedure in Example 18, Step 1-2. The reaction gave product as a pale yellow, oily solid in 36% yield. 'H NMR (400 MHz, DMSO-D6) 6 ppm 1.13 (t, J-7.33 Hz, 6 H), 3.08 (q, J=7.33 Hz, 4 H), 6.96 (d, J=7.58 Hz, 2 H). 7.10 (m, 1 H). Step 2: To methyl 4-{2-{2-{2-aminoethyl)-1-enzhydryl-5-chloro-1H-(ndol-3- yl]ethoxy}benzoate was acided 2,6-diethylbenzenesutfonyl chloride according to the procedure in Example 1, Step 7 to afford product in 72% yield. 1H NMR (400 MHz, DMSO-D6) 5 ppm 1.10 (t, J=7.33 Hz, 6 H), 2.91 (m, 6 H), 2.99 (m, 2 H), 3.11 (t, J=6.69 Hz, 2 H), 3.81 (s, 3 H), 4.18 (t, Je6.69 Hz, 2 H), 6.49 (d, J=8.84 Hz, 1 H), 6.80 (dd. J=8.84,2.02 Hz, 1 H), 6.93 (d, J=8.84 Hz, 2 H), 6.97 (s, 1 H), 7.02 (m, 4 H), 7.17 (d, J*7.58 Hz, 2 H), 7.32 (m, 5 H), 7.38 (t, J=7.71 Hz, 1 H), 7.65 (d, Je2.02 Hz. 1 H). 7.74 (t J=5.94 Hz, 1 H). 7.85 (d, J=8.84 Hz, 2 H). Step 3: The ester intermediate was hydrolyzed according to Step 8, Example 1 to afford the title acid in 88% yield. 1H NMR (400 MHz, DMSO-D6) Sppm 1.10 (t. J=7.33 Hz, 6 H), 2.91 (m. 6 H). 2.98 (d, J=7.83 Hz, 2 H), 3.10 (t, J=6.57 Hz, 2 H), 4.17 (t, J=€69 Hz. 2 H), 6.49 (d, J=8.84 Hz. 1 H), 6.80 (dd, J=8.84,2.02 Hz. 1 H), 6.91 (d, J=9.09 Hz, 2 H), 6.97 (s, 1 H), 7.02 (m, 4 H), 7.17 (d, J=7.58 Hz, 2 H), 7.32 (m, 5 H), 7.38 (t, J=7.58 Hz, 1 H), 7.65 (d, J=2.27 Hz, 1 H). 7.74 (t, J*5.81 Hz. 1 H). 7.83 (d, J=8.84 Hz, 2 H). HRMS calc for [C39H34CI2N2O5S+ H] 721.24975 found 721.24876. Example 273:4-{3-[1-benzhydryl-6-chloro)2-(2-a(2l6- diethytphftnyl)sulfonyl]amlno}ethyl)-1H- Indol-3-yl]propytybenzoic acid Step 1: To methyl 4-42-[2-mirK)ethyl)-1-benzhydryl-5-chlc)ro-1H-indol-3- yl]propyl]benzoate was acided 2,6-diethylbenzenesulfonyl chloride (Example 268, Step 1) according to the procedure in Example 1, Step 7 to generate the product in 71% yield. 1H NMR (400 MHz, DMSO-06) 5 ppm 1.11 (t, J=7.33 Hz, 6 H), 1.81 (m, 2 H), 2.65 (m, 4 H), 2.84 (m, 2 H), 2.90 (m, 6 H), 3.84 (s, 3 H), 6.44 (d, J=8.84 Hz, 1 H), 6.77 (dd, J=8.84,2.02 Hz, 1 H), 6.94 (s, 1 H), 7.02 (m, 4 H), 7.19 (d, J-7.58 Hz, 2 H), 7.33 (m, 7 H), 7.40 (t, J=7.71 Hz, 1 H), 7.43 (d, J=2.02 Hz, 1 H), 7.70 (t, J*5.68 Hz, 1 H), 7.86 (d, J=8.34 Hz, 2 H). Step 2: The ester intermediate was hydroryzed according to Step 8, Example 1 to afford the title acid in 85% yield. 1H NMR (400 MHz, DMSO-D6) 5 ppm 1.11 (t, J*7.33 Hz, 6 H), 1.81 (m, 2 H), 2.65 (m, 4 H), 2.84 (m, 2 H), 2.91 (m. 6 H), 6.45 (d, J-8.84 Hz, 1 H), 6.77 (dd, J=8.84, £02 Hz, 1 H), 6.95 (s, 1 H), 7.02 (m, 4 H),7.19 (d, J=7.58 Hz, 2 H), 7.28 (d. J=8.34 Hz, 2 H). 7.33 (m, 5 H), 7.40 (m, 1 H), 7.43 (d, J=2.27 Hz, 1 H), 7.70 (t, J=5.68 Hz, 1 H), 7.84 (d, J=8.34 Hz. 2 H). HRMS calc for C39H34CI2N2O5S + H] 719.27049 found 719.27028. Example 274:4-{2-{1-benzhydryl-S(:hloro-2-[2-a(2,e. dimethoxypheny1)sulfony1]amlno)ethyl)- 1H-ndol-3-qethoxy}benzoic acid Stop 1:1,3-dimethoxybenzene (1.0 eq). was taken up in dkrthy ether (0.2M) and n-butyilithium (1.0 eq.) was acided dropwise. The reaction was heated to reflux for three hours. It was cooled to room temperature then it was placed in a dry ice acetone bath and cooled to -50°C. Bromide (0.98 eq.) was acided and the reaction was allowed to warm slowly to room temperature. The reaction was quenched with saturated sodium thiosulfate and the aqueous layer was extracted with ether. The organic extracts were washed with brine, dried over sodium sultate and concetrated to give a brown soNd. The solid was recrystaHzed from hexanes to give the product as a white solid in 27% yield. 1H NMR (400 MHz, DMSO-D6) 8 ppm 3.83 (s, 6 H), 6.73(d, J=834 Hz, 2 H), 7.30(t, J=8.34 Hz, 1 H). Step 2: 2,6-Dimethoxybenzenesutfonyl chloride was prepared from 2-bromo- 1,3-dimethoxybenzne according to the procedure in Example 1, Step 1. The reaction gave a mixture of suffonyl chloride and another product as a white solid. Step 3. To methyl 4-{2-{2-(2-aminoethyl)-1-ben2hydryl-5-chloro-1H-indol-3- yl]ethoxy)benzoate was acided 2,6-dimethoxybenzenesulfonyl chloride according to the procedure in Example 1, Step 7 to afford product in 72% yield. 1H NMR (400 MHz, CDCI3) 5 ppm 3.08 (m, 2 H), 3.14 (m, 2 H), 3.20 (t, J=6.69 Hz, 2 H),3.64 (s, 6 H), 3.88 (s, 3 H), 4.18(t. J=669 Hz, 2 H), 5.41 (t, J=5.68 Hz. 1 H), 6.42(d, J=8.84 Hz, 1 H), 6.52 (d, J=8.59 Hz, 2 H), 6.79 (m, 3 H), 6.91 (s, 1 H), 7.02 (m, 4 H), 7.25 (m, 6 H), 7.36 (t, J=8.46 Hz. 1 H, 7.54 (d, J=2.02 Hz, 1 H), 7.93 (d, J*8.84 Hz, 2 H). m/z (M-) 737. Step 4. The ester intermediate was hydroiyzed according to Step 8, Example 1 to afford the title acid in 100% yield. 1H NMR (400 MHz, CDCI3) 5 ppm 3.08 (m, 2 H), 3.15 (m, 2 H), 3.21 (t, J=6.69 Hz, 2 H), 3.64 (s. 6 H). 4.20 (t, J=6.57 Hz, 2 H), 5.44 (m, 1 H). 6.42 (d. Je8.84 Hz, 1 H), 6.53 (d, Je8.59 Hz, 2 H). 6.79 (dd, J=8.84, 2.02 Hz, 1 H), 6.83 (d, J=8.84 Hz, 2 H), 6.91 (s, 1 H), 7.02 (m, 4 H), 7.25 (m, 6 H) .7.36 (t, Je8.46 Hz, 1 H), 7.54 (d, J=2.02 Hz, 1 H), 7.98 (d, J=8.84 Hz, 2 H). HRMS calcfor C39H34CI2N2O5S+ H] 725.20729 found 719.27028. Example 275:4-(H1-benzhydry1-5-chlora-2-(2-[(2,6- dimethoxyphenyl)sulfonyl]amlno}ethyl)- 1H-indol-3-yf]propyl}benzoic acid Step 1: To methyl 4-2-{2-(2-aminoethyl)-1-benzhydryl-5-chlorx)-1H-Jndol-3- yl]propyl]benzoate was acided 2,6-dimethoxybenzenesulfonyl chloride(Exampte 270, Step 1) according to the procedure in Example 1, Step 7 to generate the product in 80% yield. *H NMR (400 MHz, CDCI3) 5 ppm 1.94 (m, 2 H), 2.72 (m. 4 H), 3.01 (m, 4 H), 3.59 (s. 6 H), 3.91 (s, 3 H), 5.37 (m, 1 H). 6.37 (d. J=8.84 Hz, 1 H), 6.53 (d, J=8.59 Hz, 2 H), 6.76 (dd, J=8.97,2.15 Hz, 1 H), 6.84 (s, 1 H), 6.98 (m. 4 H), 7.21 (d, J=8.34 Hz. 2 H), 7.26 (m, 6 H), 7.38 (m. 2 H), 7.94 (d, J=8.34 Hz. 2 H). m/z (M+) 737. Step 2: The ester intermediate was hydroiyzed according to Step 8, Example 1 to afford the title acid in 91% yield. 1H NMR (400 MHz, CDCI,) 5 ppm 1.95 (m. 2 H). 2.74 (m, 4 H), 3.02 (m. 4 H), 3.60 (s. 6 H), 5.41 (s, 1 H), 6.37 (d, J=8.84 Hz. 1 H), 6.53 (d, J-8.59 Hz, 2 H), 6.76 (dd, J*8.84,2.27 Hz, 1 H). 6.84 (s, 1 H). 6.99 (m, 4 H). 7.25 (m, 8 H), 7.37 (t, J=8.46 Hz, 1 H), 7.40 (d, Je=2.02 Hz, 1 H), 7.99 (d, J=8.34 Hz, 2 H). HRMS calc for C39H34CI2N2O5S + H] 723.22902 found 723.22893. Example 276:4-2H1-Benzhydry-5-itro-2-[3-phenylmetHanesutfonyl-propy1)-1H- indol-3-yl]-€thoxyH)enzoic acid Step 1. 4-Nitroaniline (1.0 eq.) was taken up in water (0.8 M) and concetrated Ha (10.8 M). Iodine monochloride (1 eq.) was acided to a 4 to 1 solution of water and concetrated Ha (1.3 M) and cooled to 0°C. The ICI solution was acided to the aniline solution and the reaction sat at room temperature for 20 hours. The reaction was filtered to give the iodinated product as a yellow solid in 97.3% yield. 1H NMR (300 MHz, DMSO-D6) 5 ppm 6.75 (d, J=9.07 Hz, 1 H), 7.98 (dd, J=9.07,2.47 Hz, 1 H), 8.40 (d. J=2.47 Hz. 1 H). MS mfe 263 (M-H). Step 2. Tothe2-k)dc-4-nltroaniline(1eq.) and berizhydrylbromide(1.3 eqwere taken up in dichloroetHane (0.8 M). Difeopropylethylamine (1.1 eq.) was acided and the reaction heated to 50° C for 20 hours. The reaction mixture was cooled and washed with 1 N Ha, dried over Na2SO4 and concentrated. Purifiction using flash chromatography (10% ethyl acetate in hexanes) gave the alkylated product in 81% yield. 1H NMR (400 MHz, CDCl2) 8 ppm 5.56 (d, J=4.80 Hz, 1 H), 5.67 (d, J=5.05 Hz, 1 H), 6.36 (d, J=9.10 Hz. 1 H), 7.32 (m, 6 H), 7.38 (m, 4 H), 7.99 (dd. J=9.09,2.53 Hz, 1 H) 8.61 (d. J=2.53 Hz, 1 H). Step 3. BenzhydryH4-nitro-2-iodo-phenyl)-amkie (1 eq.), 4-(6-hydroxy-hex-3- ynyk)xy)-benzoic acid methyl ester (1.5 eq.), UCI (1 eq.) KOAc (5 eq.) and palladium (II) acetate (0.04 eq.) were acided to a roundbottom containing 10 mL of DMF tHat Had been degassed with argon. The reaction heated to 100 °C 7.5 hours. It was then cooled, diluted with ethyl acetate, washed with water and brine, dried over Na2SO4 and concentrated to give a brown solid. Purification by flash chromatography gave two products, 4-[1-benzhydryl-5nitro-5-2-[24tydroxy-ethyl)-1H-indol--3yl]-ethoxy benzoic acid methyl ester and the desired, 4-{2-{1-benzhydryl-5-nitro-3-{2-nyclroxy- ethyf)-1H-indol-2-yl]-ethoxy}-benzoic acid methyl ester in an overall yield of 71%. The products were not separable by flash chromatography and were both carried on to the next step. 1H NMR (400 MHz, CDO,) 5 ppm 1.66 (t, J=5.56 Hz, 1 H), 1.80 (t, J=5.18 Hz, 1 H), 3.14 (m, 4 H), 3.35 (m, 4 H), 3.81 (m, 2 H), 3.87 (m, J=1.52 Hz, 6 H), 3.97 (q, J=6.32 Hz, 2 H), 4.10 (t, J=6.82 Hz, 2 H), 4.31 (t, J=6.19 Hz, 2 H). 6.58 (d. JM.04 Hz, 1 H), 6.60 (d, J=4.04 Hz, 1 H). 6.67 (d, J=9.10 Hz, 2 H), 6.89 (d, J=8.84 Hz, 2 H), 7.10 (m, 9 H), 7.20 (s, 1 H), 7.32 (m, 12 H), 7.75 (m, 2 H), 7.90 (d, J=8.84 Hz, 2 H), 7.95 (d, J=9.09 Hz, 2 H), 8.52 (d, J=2.27 Hz. 1 H), 8.59 (d, J=2.27 Hz,1H). Step 4. The regiosiomers(1.0 eq.) from the previous step were taken up in THF. Triethylamine (1.2 eq.) and metHanesuffonyl chloride (1.2 eq.) were acided. The reaction stirred until the starting material was consumed as monitored but TLC. The reaction was diluted with dichlorometHane and washed with water and brine. It was dried over Na-C- and concentrated. The reaction gave an inseparable mixture of isomers in 100% yield. 1H NMR (400 MHz, CDCJS) S ppm 2.81 (s, 3 H), 2.90 (s, 3 H), 3.35 (m, 8 H), 3.87 (m, J=1.52 Hz, 6 H), 4.07 (t J=6.19 Hz, 2 H), 4.14 (t Je7.20 Hz, 2 H), 4.30 (t, J=6.06 Hz. 2 H), 4.49 (t, J=6.69 Hz. 2 H), 6.62 (d, J=6.57 Hz, 1 H), 6.65 (d, J=6.57 Hz, 1 H), 6.69 (d. J=8.84 Hz, 2 H), 6.88 (d, J=9.09 Hz, 2 H), 7.02 (s, 1 H), 7.10 (dd, J=7.71,4.67 Hz, 8 H). 7.23 (s, 1 H), 7.34 (m. 12 H). 7.79 (m, 2 H), 7.91 (d. J=8.84 Hz, 2 H), 7.96 (d, J=8.84 Hz, 2 H), 8.49 (d, J=2.27 Hz, 1 H), 8.62 (d, J=2.02 Hz,1H). Step 5. The mixture of crude mesylates (1 eq.) from above and sodium azkte (2.2 eq.) were taken up in DMSO (0.05 M). The reaction stirred at room temperature until the starting material was consumed as monftered by TLC. The reaction was dHuted with ethyl acetate, washed with water and brine, dried over Na2SO, and concentrated to give the desired azktes in quantitative yield. *H NMR (400 MHz, CDCIs) 5 ppm 3.12 (m, 4 H), 3.33 (m, 6 H), 3.64 (t, J=6.82 Hz, 2 H). 3.88 (m. J=1.52 Hz, 6 H), 4.05 (t, J=6.32 Hz, 2 H), 4.29 (t, J=6.19 Hz, 2 H), 6.65 (m, 4 H), 6.87 (d. J=8.84 Hz, 2 H). 7.02 (s, 1 H), 7.10 (m, 8 H). 7.21 (s, 1 H), 7.34 (m, 12 H), 7.78 (m, 2 H), 7.91 (d, J=8.84 Hz, 2 H), 7.96 (d. J=8.84 Hz, 2 H). 8.49 (d, J-2.27 Hz, 1 H), 8.61 (d, J=2.27 Hz. 1 H). Step 6. The mixture of inseperable azides (1.0 eq.) from Step 5 and triphenylphosphine (1.1 eq.) were taken up in THF and stirred at room temperature until the starting material was consumed giving a product with a higher Rf by TLC. 1 ml of water was acided to the reaction and it continued to stir at room temperature until TLC showed the disapperance of the higher Rf intermediate. The THF was removed in vacuo and the resulting solid was taken up in ethyl acetate, washed with water and brine, dried over Na2SO4 and concentrated. Purification by flash chromatography gave 43% overall yield of reduced products. The regiolsomers where separated using flash chromatography (gradient edition 0.25% metHanol in dichtorometHane to 10% metHanol in dichlorometHane.) The regiolsomers were identified by NMR and the desired compound, 4-{2-I2-(2-Amino-ethyl)-1-benzhydryl- 5-nitro-1 H-indol-3-yfJ-ethoxy}-Denzoic acid methyl ester, was taken on to the next step. 1H NMR (400 MHz, CDCb) 8 ppm 3.30 (m, 6 H), 3.88 (s, 3 H), 4.27 (t, J=6.57 Hz, 2 H), 6.56 (d, J=9.35 Hz, 1 H), 6.88 (d, J=9.10 Hz. 2 H), 7.10 (dd, J=6.44,2.65 Hz. 4 H), 7.32 (m. 7 H). 7.72 (dd. J=9.09,2.27 Hz, 1 H). 7.95 (d. J=8.84 Hz, 2 H), 8.60 (d, J=2.27 Hz, 1 H). MS m/z 550 (M+). Step 7. To 4-2-2-[2-Amino-thyl)-1-benzhydryl-5-nitn)-1H-indol-3-yn- ethoxy}-benzoic acid methyl ester was acided a-tohienesulfonyi chloride according to the procedure in Example 1, Step 7 to generate the product in 61% yield. 1H NMR (400 MHz, CDCIs) 5 ppm 2.89 (m, 2 H) 3.09 (m. 2 H). 3.25 (t, J=G.O6 Hz, 2 H). 3.88 (s. 3 H). 4.09 (s, 2 H), 4.15 (m. 1 H). 4.25 (t, )6.06 Hz, 2 H), 6.61 (d, J=9.35 Hz, 1 H), 6.84 (d. J=8.84 Hz, 2 H), 6.97 (s, 1 H), 7.07 (m, 4 H),7.20 (m, J=8.08,1.52 Hz. 2 H),7.32 (m, 9 H), 7.77 (dd, J*9.10,2.27 Hz, 1 H), 7.95 (d, -=9.10 Hz, 2 H), 8.59 (d, J=2.27 Hz, 1 H). MS mfz 703 (M-H). Step 8: The ester intermediate was hydroryzed according to Step 8, Example 1 to afford the title acid in 75% yield. 1H NMR (400 MHz, CDCfe) 6 ppm Z90 (m, 2 H), 3.10 (m. 2 H), 3.26 (t, -=6.06 Hz. 2 H). 4.10 (s. 2 H), 4.26 (t, -=6.06 Hz, 2 H), 4.37 (t )6.19 Hz, 1 H), 6.61 (d, J-9.35 Hz, 1H), 6.85 (d, J=9.09 Hz, 2 H), 6.97 (s. 1 H). 7.07 (m, 4 H), 7.20 (m, 2 H), 7.32 (m, 9 H), 7.76 (dd, J=9.10,2.27 Hz, 1 H), 7.97 (d, .1=8.64 Hz, 2 H), 8.58 (d. J=2JZ7 Hz, 1 H). HRMS: caJcd. for C39H34CI2N2O5S 689.2196; found (ESI+) 690.22581. Example 277:4-{2-{1*en2hydryl-6-chloro-2-{2-[({2-[2-chloro.1- methylethyl)benzer»e}-surfonyl)srnlno]ethyf}-1 H-indol-3-yl) propyl]benzoic acid Step 1: To the methyl 4-2-2-minoethylH-benzhyd-5-chloro-1 H-indol-3- yrjpropyl]benzoate (Step 6. Example 42) was acided and 2-(2-chloro1- methylethyl)benzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 65% yield. Step 2: The ester intermediate was hydrofyzed according to Step 8 Example 1 to afford the title acid in 100% yield. HRMS calc for C39H34CI2N2O5S + H] 739.21586 found 739.21611. Example 278:4-{2-(1-Benzhydry1-2-{2-[(2-(2-chk)ro-1- methytethyl)benzene)amirKl)ethyl}-5(-loro-1H-rKlol-3-yi)ethoxy]beazoicacid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2-(2- chloro-1-methylethyl)benzenesulfonyl chloride according to the procedure in Example 1 Step 7 in 61% yield. Step 2: The ester intermediate was hydrolyzed according to Step 6 Example 1 to afford the title acid in 90% yield, m/z (M-1)=739.3 Example 279:4-14)enzhydryl-5-chlofo-2-(2-fI(2,6- dirnethylbeiizy1)sulfonyl]amlno}ethyl)-1H- indc4-3-yl]ethoxy}benzolc acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1- benzhydryk5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) and 2,6- dimethytbenzylsutfbnyl chloride according to the procedure in Example 1 Step 7 in 45% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 88% yield, m/z (M-1)=738.2 Example 280: 4-[3-(1-benzhydryl-5-hloro-2-{2- [(cycloprof)ytsulfonyl)amino]-ethyl)-1H-ndol-3-yl)propyl]berizolc acid Step 1: This compound was prepared from methyl 4-{2-(2-(2-aminoethyl)-1- benzhydryl-5(hloro-1H-indol-3-yl]ethoxy}benzoate (Step 6. Example 1) and cydopropanesulfonyl chloride according to the procedure in Example 1 Step 7 in 83% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 80% yield. HRMS calc for C39H34CI2N2O5S 626.2006; found (ESI+), 627.20734. Example 281: 4-(3-{1-beitthydryl-5-chloro-2-(2-a(2- phenyiethyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]propyl}benzoic acid Step 1: To methyl 4-2--2-amlnoethyJ)-1-ben2hydry»-5-chJoro-11H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided and OphenyletHanesulfonyl chloride (prepared foflowing a procedure In J. Org. Chem. 1984, 49, 5124-5131) according to the procedure in Example 1 Step 7 to generate the product in 77% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 82% yield. HRMS calc for C39H34CI2N2O5S 690.2313; found (ESI+), 691.2383. Example 282: 4-{2-{1-benzhydryl-5-chloro-2-(2-I(2- phenylethyl)sulfonyl]amino}emyl1H-lndol-yl]ethoxy}benzoie acid Step 1: This compound was prepared from methyl 4-{2-{2-(2-aminoethyl)-1 - tenzhydry»-5-chl(xo-1H-indol-3-yl]ethoxy}ben2oate (Step 6, Example 1) and D- phenyletHanesulfonyl chloride according to the procedure in Example 1 Step 7 in 81% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 85% yield. HRMS calcd for C40HS7aN2OsS, 692.2115; found (ESI+), 693.2185. Example 283:2--1-Berizhydry1-5-chloro-2-(2-phenylmetHarMSijlf6nyl- amino-ethyl)-1H-lndol-3-yl]eethoxy)-benzoic acid Step 1: Crude 2-1-Benrhydry-2-[2-tert-butykfiphenyl-silanyioxy)-ethyn-5- chloro-1H-indol-3-yl}-etHano) from step 6, example 142 was treated with 3-Hydroxy- . benzoicacid methyl ester according to the procedure in Example 142 step 8 to yield the desired 3(2-1-Benzhydryl-2-2--buty-diphenyl-silanynolxy)-eyhyl]-5-chloro- 1-ndol-3-y1}-ethoxy)-benzoic acid methyl ester in 85% yield. Step 2: The deprotected compound was prepared according to the procedure described for Example 142 step 9. The crude 3-{2-{1-Benzhydryl-5- chlon)-2-{2-hydroxy-ethyl)-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester was used in the next step directly without further purification. Step 3-5:3-2-2-[2-Amino-ethy))-1-benzhydryl-5-chloro-1 Wndol-3-yI]- ethoxyj-benzoic acid methyl ester was prepared according to the procedure described for example 146 steps 3-7 in 57% (3 steps). Step 6: To M2--2-mino-thyl)-1-benzhydryJ-5-chloro-11H-indol-3- yl]-ethoxy}-benzoic acid methyl ester was acided a-toluenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 73% yield. Step 7: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 88% yield. HRMS calc for C39H34CI2N2O5S + H] 679.2028 found 679.2029. Example 284:2-(2-{1-Benzhydryl-5-chloro.2-{2-(3,4-dichlon)- phenylmatfianesulfbnylamlno)-ethyl]-1H-indol-3-yl-}ethxy)benzoic acid acid Step 1: To H2--2-amlno-thyl)-1-benzhydryl-5-chloro-1H-indo(-3-yl]- ethoxyj-benzoic acid methyl ester (Step 5, Example 279) was acided 3,4- dichlorophenylmetHanesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 84% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 91% yield. HRMS calc for C39H34CI2N2O5S 747.12486 found 747.12423. Example 285:3-{2-[1-Benzhydryl-5-chloro-2-(2- phenylmetHanesurfciiylamlno-thyl)-1H4ndoK3-yl]-ethoxy}-benzoic acid Step 1: Crude 2-1-Bera]iydryl-2-[2-terf-butyWipr»n 1H-indol-3-yl}-etHanol from step 6, example 142 was treated with 2-Hydroxy-benzoic acid methyl ester according to the procedure in Example 142 step 8 to yield the desired 2-[2-1-Berehydryl-2-r2-(tert- inck)l-3-yl}-ethoxy)-benzoic acid methyl ester in 60% yield. Step 2: The deprotected compound was prepared according to the procedure described for Example 142 step 9. The crude 2-{2-{1-Benzhydryf-5- (-loro-2-(2-hydroxy-ethyl)-1/-ndol-3-yl]-ethoxy}-benzoic acid methyl ester was used in the next step directly without further purification. Step 3-5:2-{2-{2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]- ethoxyhbenzoic acid methyl ester was prepared according to the procedure described for example 146 steps 3-7 in 60% (3 steps). Step 6: To 2--K2--mino-ethyl]-1-benzhydry-5-chloro-1H-indol-3-yl]- ethoxy}-benzoic acid methyl esterwas acided a-toluenesutfbnyl chloride according to the procedure in Example 1 Step 7 to generate the product in 90% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 90% yield. HRMS calc for C39H34CI2N2O5S+ H] 679.2028 found 679.20358. Example 286:3-(2-{1-Benzhydry)-6-chloro-2-I2-(3I4-dlchloro- pheny1ine1HanesuKbnylainino)-ethyl-1H-ethyl-3yl-}ethoxy)-benzoic acid Step 1: To 2-{2-T)(2-amino-ethyl-)1-benzhydryl-5- benzoic acid methyl ester (Step 5, Example 281) was acided 3,4- oichlorophenylmetHanesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 84% yield. Step 2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 89% yield. HRMS calc for C39H34CI2N2O5S+ HI 747.12486 found 747.12457. Example 287:4-{2-(1-benzhydryl-5-chk)ro-2-(2-C({[(2,4- dk-loropheriyf)sulfany1]methyf)sulfony1)ernino]ethyr}-1 H-indol-3- yl]etnoxy]benzolc acid Stepi: To methyl 4-{2-{1-benzhydryl-5-chloro-2-(2- chloronwtHanesutfc-y1amirK)-ethyt)-11H-ethyl-3yl-}ethoxy)-benzoic acidExample 81 stepi, was acided 2,4-dichlorothiophenol according to the procedure in Example 81 step 2. The crude was purified by the preparative HPLC in 50% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield, m/z (M-1)776.92. Example 288:4-£2-(1-benzhydryi-$-chloro-2-{24(a(2l4- dMuorophenyl)thio]methylsulfonyl)amino]etnyl}-1H-iridol-3-yl)ethoxy]berizolc acid Step1: To methyl 4-{2-{1-benzhydryl-5-chlor©-2-{2- chloro(netHanesulfbnylamirK)-ethyl)-1H-n(k)l-y1]-elhoxy Example 81 stepi, was acided 2,4-dffluorothiophenol according to the procedure in Example 81 step 2. The crude was purified by the preparative HPLC in 27% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 100% yield, m/z (M-1)744.97. Example 289:4-[2-(1-benzhydryl-5-chloro-2-{2-((a(3l4- dichloropheny1)surfiny1]rnethyl}surfbnyl)arnlno]ethyf}-1H-lndol-3- yl)ethoxy]benzoic acid Stepi: The methyl 4-{2-(1-benzhydryl-5-chk)ro-2-{2-{(a(3)4- dichlorophenyl)mio]rnethyl]sulfonyl)1H-ethyl-3yl-}ethoxy)-benzoic acid 1 Example 219) in THF was oxidized with mCPBA (1.1 equlv.) The crude was purified by the flash column with 30% EtOAc/hexane in 42% yield. Step2: The ester intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid in 93% yield, m/z (M-1)795.14. Example 290:4-{2-I1-benzhydry1-5-chloro-2-(2-a(2- hydraxyphenyl)surf6nyl]andno}ethyl)-1M-inclol-3-yl]ethoxy}benzolcacid Step 1:4H2-1-Berizhydryl-5KMoro-2-H2--methyH)6nta-2,4(lienyloxy- benzenesuHbnylaniino]-ethyl]-1H-ethyl-3yl-}ethoxy)-benzoic acid (0.55 g, 0.70 mmote), (Step 1, Example 183) and 10% Pd/C (55 mg) in MeOH (30 ml) and EtOH (20 ml) was hydrogenated. The resulting mixture was filtered through CeHte and concentrated. The residue was chromatographedwith 35-40% EtOACmexane to give the desired product (0.50 g, 95%). Step 2: The ester Intermediate was hydrolyzed according to Step 8 Example 1 to afford the title acid m 90% yield. HRMS: calcd for C38H33CIN2O8S, 680.1748; found (ESK), 681.18118 Example 291: Af-{2-{1-)enzhydry1-5-chloro-3-(2-(4-{(Z)-(2,4-dloxo-1,3- thlazolidin-5-y1ldene)methyllphenoxy)ethyl)-1H-lndol-2-y1]ethylh1-(3,4- dichloropnenyl)metHanesulfonamide Step 1: The 2-1-Bet-ydryJ-2-2-te//4)utyWiphenyl-ilanyloxy)-thyl]-5-chloro-1W- indof-3-yl]-etHanoi (Step 6, Example 142) was coupled with 4-Hydroxy-benzaldehyde according to the conditions described in Example 189, Step 1 to yield 4-(2-{1- BenzhydryJ-2-[2-(tert-butyldiphenyl--silanloxy) benzaldehyde in 70% yield. Step 2: The silyl ether from above was deprotected following the Example 142, step 9 to yield 4-2-1-Berlzhydryl-5-(-k)ro-2-{2-hydroxy-ethyl)-1#H!-irldol-3-yl]-ethoxy- benzaldehyde in 90% yield. Step 3: The alcohol from above was activated by conversion to the mesylate as described in Step 10 Example 142 to yield the desired mesylate which was used without purification in the next step. Step 4: The mesylate from above was treated under the conditions described in Step 11 Example 142 to gerierate4-2-2-2-Azklo-ethyl}-1-betT2hydryl-5-chlon)1AWrKk)l- 3-yl]-ethoxy}-benzaldehyde in 98% yield (2 steps). Step 5: The mixture of 4--2-2-Azido-ethyl-1-tonzhydryl-5-criloro-1H-indol- 3-yl]-ethoxy}-benzaldehyde (1.29 g, 2.41 mmote, 1.0 equiv.), 2,4-thiazoHdine dione (0.41 g, 3.13 mmole, 1.3 equiv.) and piperidine (0.12 ml, 1.21 mmote. 0.5 equiv.) in EtOH (125 mO was refluxed overnight. EtOH was removed on vacuo. The residue was diluted in EtOAc and washed with water, then brine. The organic layer was dried over MgSO4 and concentrated, and the residue was chromatographed with 30- 35% EtQAcmexane to obtain 5K4-2-2-[2-Azkk)-ethvn-1-benzhydryl-5-chloro-1H- irxk)l-3-yl]-ethoxy}-nzy1kJer)e)-ia2oIidine.2,4-dione (1.33 g, 87%). Step 6: To a solution of the product from step 5 in THF (80 ml) was acided PhsP in small portions. The mixture was stirred for 1 day. 3 ml of water was acided, and stirred for an aciditional 2 days. The produced solid, which was identified as triphenyl phosphine imine of the above azide.(60%) by LC/MS, was filtered. Step 7: The imine (250 mg, 0.29 mmole, 1.0 equiv.) from step 6, and (3,4- dichlorophenyl]methyteuffonyl chloride in CHaCl2 (10 ml) and saturated NaHCOs (5 ml) was stirred overnight according to the procedure in Example 1 Step 7 to generate the product in 7% yield, m/z (M-1) 830.45 Example 292: N-[2-(1-Benzhydryl-5-chloro-3-{2-C4-(2,4Kiioxo-thIazolidin- 6-ylklenmnethyl)-phenoxy]-ethy-1H-ndol-2-l)-thyl]-2-fnethy|. benzenesulfonamide Step 1: The mixture of triphenylphosphine imine (300 mg, 0.35 mtnole, 1.0 equiv.) from Step 6, Example 287 and 2-methyl-benzenesurfonyl chloride in CH2CI2 (15 ml) and saturated NaHCO3 (5 ml) was stirred overnight according to the procedure in Example 1 Step 7 to generate the product in 3% yield. HRMS calc for [C42HMCIN3O6S - H] 760.1723 found 760.1728. Example 293:4-{3-{1-Benzhydry1-6-chloro-2-(2-{I(1-methyl-1H-imidazol- 2-l)sulfonyl]amino}ethyl)-1fMndol-3-yl]propyl}benzolc acid Step 1: To the methyl 4-3--2-minoethyJ)1-benzhydryt-5-chloro-1H-indol-3- yl]propyl]benzoate (Step 6, Example 42) was acided 1-MethyMH-imidazole-2- sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 70% yield. Step 2: The ester intermediate was hydroryzed according to Step 8 Example 1 to afford the title acid in 92% yield. HRMS calc for [C37H35CIN4O4S + H] 667.2141 found 667.2137. Example 294:4-(2-{1-bonzhydryl-5-chloro-2-(2-(I(1-methyM-1H-midazol-2- y1)*urfonyl]amino}ethyl)-1H-indol-3-yl}ethoxy}benzoic acid Step 1: This compound was prepared from methyl 4-{2-[2-(2-aminoethyl)-1- benzhvdryl-5-chJoro-1H-indot-3-vl]ethoxy}benzoate (Step 6, Example 1) and 1- Methyl-1H-imidazole-2-6Ulfonyl chloride according to the procedure in Example 1 Step 7 in 76% yield. Step 2: The ester intermediate was hydrolyzed according to Step 6 Example 1 to afford the title acid in 87% yield. HRMS calc for [C38H.33CIN4O6S + H] 669.1933 found 669.1933. Example 295:4-{3-(1-benzhydryl-2-(2-{[(2-chlorophenyl)sulfonyl]amino}ethyl)- 1H-indol-3- yl]propyl]benzoic acid Step 1: A mixture of methyf-4-iodobenzoate (5.3g, 20.2 mmol), allyl alcohol (1.78g, 30.3 mmoO. NaHCO, (4.24g, 50.5mmol), Pd(OAc)2 (0.14g, 0.60mmol). (n- Bw4NBr (6.55g, 20.2 mmol) and 4-A molecular Sieves (4.1g) in anhydrous DMF (69mL) was stirred at room temperature for 4 days. The reaction mixture was filtered through celite and the filtrate poured onto water and extracted with EtOAc. Organic layer was washed with brine, dried (Na2SO4-, and concentrated under vacuum. Flash chromatography (silica gel, 10-20 % EtOAc-hexanes) gave 2.11g (85% based on the recovered starting material) of the desired 4-{3-Oxo-propyl)-benzoic acid methyl ester as a dear oil. Step 2: To a solution of 2-Methy1H-indole (0.86g, 5.2mmol) and 4-(3-Oxo- propyl]-benzoic acid methyl ester (1.0g, 5.2mmoO in methylene chloride (50mL), was acided TFA (1.78g, 15.6mmoO, followed by triethylsilane (1.81g, 15.6mmol). The reaction mixture was stirred overnight quenched with sat NaHCOs solution (50mL), and the organic layer was washed with sat NaHCOs solution, water, brine, and dried (Na2SO4). Solvent was removed under reduced pressure, and the residue was purified by flash column chromatography with 10-20% EtOAc/hexanes to yield the desired 4-3-2-Me1hyl-1/-rKlot-3-yI)-propyll-benzoic acid methyl ester in 88% (1.67g) yield. Step 3: To a solution of the product from step 2 (1.66g, 4.86mmol) in DMF (20mL) was acided NaH (60% in mineral oil, 0.24g, 5.83mmoQ under N, atmosphere. The mixture was stirred for 1h at room temperature, followed by the dropwise acidition of benzhydryl bromide (1.8g, 7.29mmoQ in DMF (5mL). This reaction mixture was stirred overnight at room temperature. Water (500mL) was acided to reaction mixture, it was extracted with EtOAc, washed with brine, dried (Na2SO4), and concentrated under reduced pressure to a brown syrup, which was purified by silica- gel chromatography using 10% EtOAc/hexanes as eiuent to isolate 4-{a-(1- Benzhydryl-2-rnethyl-11H-indol-3-yl)-propyfJ-ben2oic acid methyl ester as a white solid in76%(1.47g)yield. Step 4: The product from above (1.46g, 2.87mmol) was dissolved in CCU (14.5mL), followed by the acidition of NBS (1.02g, 5.73mmol) and benzoyl peroxide (2mg). The reaction mixture was heated to reflux for 1h (until all the starting material disappeared). This mixture was cooled to room temperature, filtered and the solid was -washed with CCU- The filtrate was evaporated to a brown residue, which was dissolved in acetone (40mL) and water (4mL), Ag2CO3 (1.75g, 3.16mmof) was then acided to this solution and after being stirred overnight at room temperature, it was filtered through celite, the solvent was evaporated under reduced pressure, and water was acided to the residue. It was extracted with EtOAc, washed with brine, dried (Na2SO4), and evaporated to a syrup, which was purified by 10% EtOAc/hexanes to isolate the 4-{3-(1-Benzhydryl-2-formy1-1H-indol-3-yf)-propyl]- benzoic acid methyl ester (1.13g) in 85% yield. Alternatively the dibromide from the reaction with NBS could be poured into DMSO (10-20% concentration by weight) and stirred for 30 minutes at room temperature. When the reaction was deemed complete it was poured into water and the resulting precipitate was isolated by filtration, the cake was washed with water and dried to yield an essentially quantitative yield. Step 5: To a solution of the indole from above (0.52g, 1mmol) in CH3NO2 (6.2mL) was acided NH4OAC (0.077g, 1mmoJ), the mixture was heated to reflux for 1h, NH4OAC (0.077g, 1mmof) was then acided, heating at reflux was continued for an aciditional 1h, NKUOac (0.077g, 1mmol) was acided again and the heating continued for further 1 h. The reaction mixture was allowed to attain room temperature, EtOAc (50mL) was acided, followed by the acidition of 100mL water. The aqueous layer was extracted with EtOAc, and the combined organic layers were washed with brine, dried (Na2SO4), and evaporated to a yellow foam, which was subjected to chromatographic purification using 10% EtOAc/hexanes as an eluent to yield 4-43-fi- Berirhydryl-2-2Hriltro-nyl)-1H-irKlo4-3-ylh)ropyl}-D- acid methyl ester as a yellow foam in 75% yield (0.38g). Step 6: Zn(Hg) was made by aciding HgCfe (3.4g, 7.2 mmoO to a mixture of Zn-dust (34.68g, 530.35mmoO and 5% Ha (38mL) in a 100mL beaker, this mixture was stirred vigorously for 10 min. Aqueous pHase was decanted and acided 38mL of 5% HCI again and the mixture was stirred for 10 min. Aqueous pHase was decanted. This solid was acided to the vinyl nitro compound 6 (15g, 26.57mmol) in THF (660mL) and cone. HCI (64.5mL). This mixture was stirred at room temperature for 1 h, then at reflux for 15 min. The reaction mixture was cooled to room temperature and filtered through celite. Aq. NH4OH solution (200mL) was acided to the filtrate, stiiied for 15 min and THF was removed under reduced pressure. The aqueous layer was extracted with ChfeCb. combined organic layer was washed with brine, dried (Na2SO4) and concentrated to a brown foam, which was purified by column chromatography by eluting the column with CHCI3 in the beginning to remove non- polar impurities then with 2% MeOH/CHCfe to isolate the desired 4-{3-{2-(2-Amino- ethy-1-benzhydryl-1H-indol-3-yl)-propyl)-benzoic acid methyl ester in 40% yield (6.1g) Step 7: To the amine(1.0 equiv.) and sat NaHCOa (0.14 M) in CH2Cl2 (0.07 M) was acided 2-Chloro-benzenesutfonyl chloride (1.0 equiv.). After 1 h the mixture was poured into saturated sodium bicarbonate and extracted with CH-Cfe. The combined organic pHase was washed with brine, dried over sodium sulfate and purified by column chromatography to afford 92% of the desired 4-(3-{1-Benzhydryl- 242-2-loro4)enzenesuffony1amino)-ethyl]-1H-ethyl-3-yl-}propyl)-benzoic acid methyl ester. Step 8: The resulting ester was hydrolyzed by stirring with 1N NaOH (5 equiv.) fan THF (0.07 M) and enough MeOH to produce a clear solution. The reaction was monitored by TLC (10% MeOH-CHaCfe) for the disappearance of starting material. The mixture was stirred overnight at room temperature and then, concentrated, dluted with HaO, and acidified to pH 2-4 using 1 M Ha. The aqueous pHase was extracted with EtOAc and the organic pHase was washed with brine, dried over sodium sulfate, and concentrated to afford the title compound in 56 % yield, m/z (M-1) 663.2 Example 296:4-(2-£1-benzhydryl-5-chloro-2-(2-a(3,4. dichloit)beiizyl)suKonyl]amlno}ethyl1H-indol-3-y1]ethoxy}-2-fluorobenzoic acid Step 1: [(3,4-dichlorophenyl)methyl]8utfonyl chloride (0.07g, 0.24 mmol) was acided to a mixture of ethyl 4-{2-{2-(2-Aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]- ethoxy}-2-fluoro-benzoate (Step 6, Example 190,0.17 g, 0.2 mmol) and K2CO3 (0.055 g, 0.4 mmol) in CHjCfe (2 mL) and water (0.7 mL) with stirring. After 2 hour at room temperature, the mixture was extracted with CH2Cl2 (10 mL) and the extract waauwashed with 0.5 N NaOH, and brine and dried over sodium sulfate. The CH2CI2 solution was filtered through silica gel and the filtrate was evaporated. The resulting residue was triturated with a mixture of ether and hexanes to give 0.15 g of ethyl 4- {2-[1-benzhydryl-5-chloro-2-5-chloro-2-[24- 3-yl]ethoxy)-2-fluorobenzoate as a white solid;, mp 83-85 *C; HRMS: calcd for C41H36CI3FN2O5S. 792.1395; found (ESI+), 793.14729. Step 2: Ethyl 4-[2-{1-benzhydiyJ-5-hloro-2-(2-{r(3,4-dichloroben2y1)sutfonyI]amino)- ethyl)-1H-indol-3-yl}ethoxy}-2-fkJoroben2oate (0.11 g, 0.14 mmol), THF (0.5 mL), MeOH (0.5 mL), and 1N NaOH (0.5 mL) were stirred together overnight Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI and extracted with ethyl acetate. The extract was dried over sodium sulfate, and evaporated. The resulting residue was triturated with a mixture of ether and hexanes to give 0.10 g of 4-{2-{1-benzhydryl-5-chJoro-2-(2-ff(3l4- dkttorobenzyl)sutfonyl]amino}ethylH acid as a white solid; mp 117-119 *C; HRMS: calcd for C41H36CI3FN2O5S, 764.1082; found (ESI+), 787.09794 Example 297:4-2-[1-benzhydryl-5-chloro-2-(2-{I(2- cNorobenzyl]sirifonyl]amino}ethyl)-1H- indol-3-y!]ethoxy}-2-fluorobenzoic acid Step 1: [(2-chloropbenyl]methyl]suffonyi chloride (0.14 g, 0.6 mmol) was acided to a mixture of ethyl 4-{2-{2-(2-mlnoethyl)-1-ben2hydryl-5-chloro-1 H-indol-3-yl]-ethoxy}- 2-fluoro-benzoate (Step 6, Example 190,0.12 g, 0.2 mmol) and K3CO9 (0.11 g, 0.8 mmol) in CH2CI2 (2 mL) and water (1 mL) with stirring. After 2 hour at room temperature, the mixture was extracted with CH2CI2 (10 mL) and the extract was washed with 0.5 N NaOH, and brine and dried over sodium sulfate. The CH2CI2 solution was filtered through silica gel and the filtrate was evaporated. The resulting residue was triturated with a mixture of ether and hexanes to give 0.07 g of ethyl 4- {2-14)enrhydryf-5-chloro-2-[2-(2-lorobenzyI)3ulfonyl]amino)ethyl)-1 AMndol-3- yl]ethoxy}-2-fluorobenzoate as a white solid. Step 2: Ethyl 4--1-benzhydry-5H*loro-2-2-fl(2-chlorobenzyl)sulfonyl]amino}ethyl)- 1H-indol-3-yl]ethoxyh2-flLK)robenzoate (0.06 g, 0.1 mmol), THF (0.5 mL), MeOH (0.5 mL), and 1N NaOH (0.5 mL) were stirred together overnight Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI end extracted with ethyl acetate. The extract was dried over sodium sulfate, and evaporated. The resulting residue was triturated with a mixture of ether and hexanes to give 0.06 g of 4-{2-{1-benzhydryl-5-chloro-2-(2-{I(2- chlorobenzyJ)suffony(]amino}ethyf)-1 Wndol-3-yl}ethoxy}-2-fluorobenzoic ackJ as an off-white solid; mp 132-135 *C; MS (ESI) m/z 729.74 ((M-H»; HRMS: calcd for C41H36CI3FN2O5S, 730.1471; found (ESI+), 731.15514. Example 298:3-{4-({2-I1-*)enzhydryl-5-chloro-2-(2-{I(3,4- dichloit)benzy1)sulfonyl]amirK3}ethyt)-1H-ndol-3-ethyr}surfony1)pheny1]-2)2- dimethylpropanoic acid Step 1: [(3,4-chlorophenyl)methyfJsu»fonyJ chloride (0.06 g, 0.2 mmol) was acided to a mixture of ethyl 3-(4-{2-{2-{2-amlnoethyl)-1-ben2hydryl-5-chk)ro-1 H-indol-3-yll- etHanesulfonyrH3hen22)2(dimethyl-Dropionate (0.09 g, 0.14 mmol) and KgCOs (0.04 g, 0.28 mmol) in CH2Cl2 (2 mL) and water (0.7 mL) with stirring. After 2 hour at room temperature, the mixture was extracted with CH2Cl2 (10 mL) and the extract was washed with 0.5 N NaOH, and brine and dried over sodium sulfate. TheCH2Cl2 solution was filtered through siHca gel and the filtrate was evaporated. The resulting residue was triturated with a mixture of ether and hexanes to give 0.04 g of ethyl 3- [4-{2-1-benzhydryl-5-chk)ro-2-[2-(3l4-dichorobenzyf)8ulfonyl]amino)emy1)-1/- ino-)l-y1]ethyl}sulfofiy0phenyl]-2,2-dimethylproparioate as a white solid. Step 2: Ethyl 3-{4-({2-I1-benzhydry]-5-chloro-2-(2-a(3,4- dk*k)robenz-lfbnyl]amino)-eth- dimethylpropanoate (0.04 g, 0.05 mmol], THF (0.5 mL), MeOH (0.5 mL), and 1N NaOH (0.5 mL) were stirred together overnight Solvents were removed and the resulting residue was taken up in water. The solution was acidified with 1N HCI and extracted with ethyl acetate. The extract was dried over sodium sulfate, and evaporated. The resulting residue was triturated with a mixture of ether and hexanes to give 0.04 g of 3K4K{241-benzhydryt-5-lorcH2-[2-[I(3,4-ichtorobenzyl)- suHbnyl]amtno}ethyl)-1 H-rKlol-3-yl]ethyl}sulfof)y0phenyl}-2,2-inrtethylpr(-)anoic acid as a white solid; mp 207-208 *C; MS (ESI) m/z 849.1 (M-H); HRMS: calcd for C43H4,CI3N2O6S2( 850.1472; found (ESI+), 851.1545. Example 299:4-{2-{1-benzhydryl-6-chk)ro-2-(2-{I(3f4- dlchlorobonzyl)sulfonyaaniino}ethyl)-1H-indol-3-yl]othoxy)-2Hnethoxybenzoic acid Step 1: 2,4-Dihydroxy-benzote acid methyl ester (11.76g, 70mmol) was dissolved in Et2O (175mL). Then Et»N (10.78mL, 77mmoO, AcaO (7.28mL, 77mmol), and DMAP (catalytic amount) were acided. The reaction solution was then stirred for one hour at room temperature. Then the reaction solution was concentrated by rotary evaporation and the resulting residue was purified with a silica gel column and dichlorometHane as eluent Obtained 3.44g 4-Acetoxy-2-hydroxy-benzoic acid methyl ester in 23% yield. Step 2: MeOH (0.3mL, 7.4mmol) was acided to the product from step 1 (0.962g, 4.6mmol), PhsP (1.79g, 6.8mmol), and dichlorometHane (10mL). Then DEAD (1.32mL, 8.4mmol) was acided to the reaction. Reaction was stirred at room temperature for 4 days. Reaction solution was concentrated by rotary evaporation and the resulting residue was purified with silica gel prep plates and 1:3 EtOAc/Hexane as eluent Obtained 1.1 Og of 4-Acetoxy-2-methoxy-benzoic acid methyl ester in quantitative yield. Step 3:0.1N NaOH (10mL, 1mmol) was acided to a solution of the product of step 2 (1.1 Og, 4.9mmoO in THF (1mL) and MeOH (1mL). Reaction was stirred for three days at room temperature. Reaction solution was concentrated by rotary evaporation and resulting residue was dissolved in water. The solution was neutralized with 1N HCI and a precipitate formed. CoRected precipitate and washed with water and hexane. Obtained 0.29g of 4-Hydroxy-2-methoxy-benzoic acid methyl ester in 33% yield. Step 4:2-1-Beruhydryf-2-2-tert-butykliphenyl-lany1oxy)-€thy-5-loro-1Wmio- 3-yD-etHanol (Step 6, Example 142,0.503g, 0.78mmol) was acided to a mixture of Hydroxy-2-methoxy-benzoic acid methyl ester (0.29g, 1.6mmol), PhjP (0.312g, 1.2mmol), and dichlorometHane (10mL). Then DEAD (0.2mU 1.3mmd) was acided to the reaction. Reaction was stirred at room temperature overnight Reaction solution was concentrated by rotary evaporation and the resulting residue was purified with silica gel prep plates and dichlorometHane as eluent Obtained 0.25g of 4-(2-(1- Benzhydiyl-2-(tert)-butyl-diphenyl-silanyloxy)-ethyl]-5-chloro-1H-indol-3-yl-}ethoxy)- 2-methoxy-benzoic acid methyl ester in 40% yield. Ste* 5: TBAF (1M in THF) (0.37mL, 0.37mmoO was acided to a solution of 4-(2-{1- Benzhydryl-2-tert)-diphenyl-silanyloxy)-ethyl-5-chloro-1H-indol-3-yl-}ethoxyl) 2-methoxy-benzoic acid methyl ester (0.25g, 0.31 mmol) in THF (4mL). Reaction was stirred at room temperature for 30 minutes. Reaction solution was concentrated by rotary evaporation and the resulting residue was purified with silica gel prep plates and 1:9 EtOAc/dichlorometHane as eluenL Obtained 0.11g of 4-{2-{1-Benzhydryl-5- chloro-2-[2-ydroxy-thyl)-1H-indol-3-yl]-ethoxy}-2-niethoxy-benzoic acid methyl ester (white solid) in 62% yield. Step 6: MeSOjCI (0.03mL, 0.39mmol) and EfeN (0.07mL, 0.48mmol) were acided to a solution of the alcohol from step 5 (0.11g, 0.19mmol) in dichlorometHane (8mL) at 0°C. Reaction was stirred at 0°C for one hour and then warmed to room temperature and stirred an aciditional hour. Reaction solution was concentrated by rotary evaporation. Obtained 0.123g of 4-{2-{1-Benzhydryl-5-chloro-2-(2- metHanesurrbnyloxy-ethyl)-1/Mndol-3-yl}-ethoxy}-2HTieth acid methyl ester in quantitative yield. Step 7: The mesylate from above (0.123g, 0.19mmoO was dissolved in DMF (5mL). NaNj (0.065g, LOmmoJ) was acided and the mixture was healed to 60°C and stirred for three hours. Reaction was cooled to room temperature and water was acided. Extracted with EtOAc and washed organic layer with brine. Dried organics over sodium sulfate and filtered and concentrated by rotary evaporation. Dried further under a strong vacuum. Obtained 0.110g of 4-{2-{2-(2-Azido-ethyl)-1-benzhydryl-5- chloro-1 WrKJol-3-yri-ethoxy-2-methoxy-benzoic acid methyl ester in 07% yield. Step 8: PhsP (polymer support 3mmol PhjP/gram) (0.110g, 0.33mmoO was acided to a solution of the aside from step 7 (0.110g, 0.18mmol) in THF (2mL). Reaction was stirred at room temperature for 24 hours. Then water (0.5mL) was acided and reaction was stirred at room temperature overnight Reaction solution was filtered and the filtrate was concentrated by rotary evaporation. The resulting residue was purified with silica gel prep plates and 2% MeOH in dichlorometHane as eluent. Obtained 0.012g of 4-42-2-Amino-ethyl)-1-benzhydryl-5-lorc)-1H- indol-3-yl]- ethoxy}-2-methoxy-benzoic acid methyl ester in 12% yield. Step 9: An aqueous, saturated solution of Na2CO3 (2mL) was acided to a solution of the amine from step 8 (0.012g, 0.021 mmoO and [(3,4-dichlorophenyl]methyl]surrbnyl chloride (0.010g, 0.039mmol) in dichlorometHane (2mL). Reaction was stirred at room-temperature for two hours. The reaction solution was then separated and the organic pHase was collected and washed with brine and dried over sodium suffate. Filtered and concentrated the organic solution by rotary evaporation. The resulting residue was purified with silica gel prep plates and 2% MeOH in dichlorometHane as eluent Obtained 0.016g of the desired suHbnamide (white solid) in 96% yield, m/z (M+1)793 Step 10:1N NaOH (1mL) was acided to a solution of the ester from step 9 (0.016g. 0.020mmoO in THF (1mL) and MeOH (1mL). Reaction was stirred at room temperature for five days. The THF and MeOH were removed by rotary evaporation. Extracted with dichlorometHane and separated and collected the aqueous layer. Neutralized the aqueous layer with 1N HCI and collected the resulting precipitate. Obtained 0.013g of the title acid (yellow solid) in 84% yield, m/z (M-1)777. Example 300:4-1-benzhydryl-5-criloro-2-(2-{[(3,4- dichlorobenzyl)surfonyl]amino}ethyl)-1H- indoU3-yl]ethoxy}-2- Isopropoxybenzoic acid Step 1: Isopropanol (0.63mL, 8.2mmoO was acided to a mixture of 4-Acetoxy-2- methoxy-benzoic acid methyl ester (Step 1, Example 299,1.18g, 5.6mmol), Ph3P (1.84g, 7.0mmol), and dichlorometHane (15mL). Then DEAD (1.12mL, 7.1mmoO was acided to the reaction. Reaction was stirred at room temperature for two days. Reaction solution was concentrated by rotary evaporation and the resulting residue was purified with silica gel prep plates and 1:5 EtOAc/Hexane as eluent Obtained 1.11g of 4-Acetoxy-2-isopropoxy-benzoic acid methyl ester in 79% yield. Step 2:0.1N NaOH (10mL, 1mmol) was acided to a solution of 4-Acetoxy-2- isopropoxy-benzoic acid methyl ester (0.910g, 3.6mmol) in THF (1mL) and MeOH (1mL). Reaction was stirred for three days at room temperature. Reaction solution was concentrated by rotary evaporation and resulting residue was dissolved in water. The solution was neutralized with 1N HCI and a precipitate formed. Collected precipitate and washed with water and hexane. Obtained 0.870g of 4-Hydroxy-2- isopropoxy-benzoic acid methyl ester in quantitative yield. Step 3:2-1-Benzhydry1-2-2-tert-butyl-phenyl-silanyloxy)-ethyl]-5-chloro-1H-indol- 3-yl)etHanol (Step 6, Example 142,0.500g, 0.78mmol) was acided to a mixture of 4- Hyd/oxy-2-isopropoxy-benzoic acid methyl ester (0.328g, 1.6mmol), Ph3P (0.312g, 1.2mmol), and dicNorometHane (10mL). Then DEAD (0.2mL, 1.3mmol) was acided to the reaction. Reaction was stirred at room temperature overnight. Reaction solution was concentrated by rotary evaporation and the resulting residue was purified with silica gel prep plates and dichlorometHane as eluent Obtained 0.20g of 4-(2-{1- Benzhydrvl-2-fe/**)utyWphenyl(- 2-isopropoxy-benzoic acid methyl ester in 31% yield. Step 4: TBAF (1M in THF) (0.29ml_, 0.29mmol) was acided to a solution of the silyl ether from step 3 (0.20g, 0.24mmol) in THF (4mL). Reaction was stirred at room temperature for 30 minutes. Reaction solution was concentrated by rotary evaporation and the resulting residue was purified with silica gel prep plates and 1:9 EtOAc/dichlorometHane as eluent Obtained 0.10g of 4-{2-{1-Benzhydryl-5-chloro-2- (2-hydroxy-ethyl)-1H-indol-3-yl]-ethoxy-2--isopropoxy-benzoic acid methyl ester (brown solid) in 70% yield. Step 5: MetHane sulfonyl chloride (0.03mL. 0.39mmol) and Et,N (O.OGmL, 0.43mmol) were acided to a solution of the alcohol from Step 4 (0.10g, 0.17mmol) in dichlorometHane (8mL) at 0°C. Reaction was stirred at 0°C for one hour and then wanned to room temperature and stirred an aciditional hour. Reaction solution was concentrated by rotary evaporation. Obtained 0.115g of 4-{2-{1-Benzhydryf-5-criloro- 2-(2-metHanesulfonyloxy-ethyr)-1 /Mndol-3-yl]-ethoxy}-2-isopropoxy-benzoic acid methyl ester in quantitative yield. Step 6: The mesytate from Step 5 (0.115g, 0.17mmol) was dissolved in DMF (5mL). NaN, (0.065g, LOmmol) was acided and the mixture was heated to 60°C and stirred for three hours. Reaction was cooled to room temperature and water was acided. Extracted with EtOAc and washed organic layer with brine. Dried organics over sodium sutfate and filtered and concentrated by rotary evaporation. Dried further under a strong vacuum. Obtained 0.1 OOg of 4-{2-{2-{2-Azid(-ethyt)-1-benzhydry|.5- chtoro-1H-indol-3-yl]-ethoxyl}-2-isopropoxy-ben2dc acid methyl ester in 94% yield. Step 7: PfeP (polymer support 3mmol Ph3P/gram) (0.100g, 0.30mmol) was acided to a solution of the azide from Step 6 (0.100g, 0.16mmol) in THF (2mL). Reaction was stirred at room temperature for 24 hours. Then water (0.5mL) was acided and reaction was stirred at room temperature overnight Reaction solution was filtered and the filtrate was concentrated by rotary evaporation. The resulting residue was purrfid with silica gel prep plates and 2% MeOH in dichlorometHane as eluent. Obtained 0.020g of 4-[2-[2-(2-Amino-ethyf)-1-benzhydryl-5-chloro-1H-indol-3-yl]- ethoxy}-2-isoprapoxy-benzoic acid methyl ester in 21% yield. Step 8: An aqueous, saturated solution of Na2CO3 (2mL) was acided to a solution of the amine from Step 7 (0.020g, 0.034mmol) and [(3,4-dichlorophenyl)methyf]sutfonyl chloride (0.01 Sg, 0.058mmol) in dichlorometHane (2mL). Reaction was stirred at room temperature for two hours. The reaction solution was then separated and the organic pHase was collected and washed with brine and dried over sodium sutfate. Filtered and concentrated the organic solution by rotary evaporation. The resulting residue was purified with silica gel prep plates and 2% MeOH in dichlorometHane as eluent Obtained 0.022g of the desired sulfbnamide (white solid) in 79% yield, mfe (M+1)821 Step 0:1N NaOH (1mL) was acided to a solution of the ester from Step 8 (0.022g, 0.027mmol) in THF (1mL) and MeOH (1mL). Reaction was stirred at room temperature for five days. The THF and MeOH were removed by rotary evaporation. Extracted with dichlorometHane and separated and collected the aqueous layer. Neutralized the aqueous layer with 1N HCI and collected the resulting precipitate. Obtained 0.021g of the title acid (yellow solid) in 96% yield, m/z (M-1)805 Activity Assay Coumarine Assay 7-hydroxycoumarinyl 6-heptenoate was used as a monomeric substrate for CPLA2 as reported previously (Huang, Z. et al., 1994, Natytical Biochemistry 222, 110-115). Inhibitors were mixed with 200 uL assay buffer (80 mM Heped, pH 7.5.1 mM EDTA) containing 60 uM 7-hydroxycoumarinyl 6-heptenoate. The reaction was initiated by aciding 4 ug cPLA2 in 50 uL assay buffer. Hydrolysis of the 7- hydroxycounarimyl 6-heptenoate ester was monitored in a fluorometer by exciting at 360 nm and monitoring emission at 460 nm. Enzyme activity is proportional to the increase in emission at 460 nm per minute. In the presence of a cPLA2 inhibitor, the rate of increase is less. The compounds of the Invention Inhibit cPLA2 activity tHat is required for supplying arachidonic acid substrate to cyclooxygenase -1 or 2 and 5-iipoxygenase, which in turn initiate the production of prostaglandins and leukotrienes respectively. In acidition, cPLA2 activity is essential for producing the lyso-phospholipid tHat is the precursor to PAF. Thus these compounds are useful in the treatment and prevention of disease states in which leukotrienes, prostaglandins or PAF are involved. Moreover, in diseases where more tHan one of these agents plays a role, a cPLA2 inhibitor would be expected to be more efficacious tHan leukotriene, prostagiandin or PAF receptor antagonists and also more effective tHan cyclooxygenase or 5-iipoxygenase inhibitors. Therefore, the compounds, pHarmaceutical compositions and regimens of the present invention are useful in treating and preventing the disorders treated by cydooxygenase-2, cydoxygenase-1, and 5-lipoxygenase inhibitors and also antagonists of the receptors for PAF, leukotrienes or prostaglandins. Diseases treatable by compounds of this invention include but are not limited to: pulmonary disorders including diseases such as asthma, chronic bronchitis, and related obstructive airway diseases; allergies and allergic reactions such as allergic rhinitis, contact dermatitis, allergic conjunctivitis, and the like; inflammation such as arthritis or inflammatory bowel diseases, skin disorders such as psoriasis, atopic eczema, acne, UV damage, bums and dermatittis; cardiovascular disorders such as atherosclerosis, angina, myl]cardial iscHaemia, hypertension, platelet aggregation, and the like; and renal insufficiency induced by immunological or chemical. The drugs may also be cytoprotective, preventing damage to the gastrointestinal mucosa by noxious agents. The compounds will also be useful in the treatment of adult respiratory distress syl]drome, endotoxin shock and ischeamia induced injury including myl]cardial or brain injury. The methods of treatment, inhibition, alleviation or relief of asthma of this invention include those for Extrinsic Asthma (also known as Allergic Asthma or Atopic Asthma), Intrinsic Asthma (also known as Nonallergic Asthma or Nonatopic Asthma) or combinations of both, which Has been referred to as Mixed Asthma. The methods for those experiencing or subject to Extrinsic or Allergic Asthma include incidents caused by or associated with many allergens, such as pollens, spores, grasses or weeds, pet danders, dust, mites, etc. As allergens and other irritants present themselves at varying points over the year, these types of incidents are also referred to as Seasonal Asthma. Also included in the group of Extrinsic Asthmas is bronchial asthmas and allergic bronchopufminary aspergillosis. Intrinsic Asthmas tHat may be treated or alleviated by the present methods include those caused by infectious agents, such as cold and flu viruses in adults and respiratory syl]cytial virus (RSV), rhinovirus and influenza viruses common in children. Also included are the asthma conditions which may be brought about in some asthmatics by exercise and/or cold air. The methods are useful for Intrinsic Asthmas associated with industrial and occupational exposures, such as smoke, ozone, noxious gases, sulfur dioxide, nitrous oxide, fumes, including isocyanates, from paint, plastics, polyuretHanes, varnishes, etc., wood, plant or other organic dusts, etc. The methods are also useful for asthmatic incidents associated with food aciditives, preservatives or pHarmacological agents. Common materials of these types are food coloring such as Tartrazine, preservatives like bisulfites and metabisulfites, and pHarmacological agents such as aspirin and non-steroidal anti- Inflammatory agents (NSAIDs). Also included are methods for treating, inhibiting or alleviating the types of asthma referred to as Silent Asthma or Cough Variant Asthma. The methods herein are also useful for treatment and alleviation of Intrinsic Asthma associated with gastroesopHageal reflux (GERD), which can stimulate bronchoconstriction. GERD, along with retained bodily secretions, suppressed cough, and exposure to allergens and irritants in the bedroom can contribute to asthmatic conditions and Have been collectively referred to as Nighttime Asthma or Nocturnal Asthma. In methods of treatment inhibition or alleviation of asthma associated with GERD, a pHarmaceuticalry effective amount of the compounds of this invention may be used as described herein in combination with a pHarmaceutically effective amount of an agent for treating GERD. These agents include, but are not limited to, proton pump inhibiting agents like PROTONIX* brand of delayed-release parrf&wazole sodium tablets, PRILOSEC* brand omeprazole delayed release capsules, ACIPHEX* brand rebeprazote sodium delayed release tablets or PREVACID* brand delayed release lansoprazole capsules. These compounds will be especially useful in the treatment of arthritic and/or rheumatic disorders, including but not limited to rheumatoid arthritis, spondytoarthropathies, gouty arthritis, osteoarthritis, systemic lupus erythematosus and juvenile arthritis. The compounds of this invention will be useful in the treatment of post- operative inflammation including tHat following ophtHalmic surgery such as cataract surgery or refractive surgery The compounds of this invention can be used as an antipyretic agent The compounds of this invention may be utilized in methods of treating pain, particularly the pain associated with inflammation. Specific methods include, but are not limited to, those for treating centrally mediated pain, peripherally mediated pain, musculo- skeietal pain, kjmbosacral pain, structural or soft tissue injury related pain, progressive dteease related pain, such as oncology and degenerative disorders, neuropathic pain, which can include both acute pain, such as acute injury or trauma, pre and post-surgical, migraine pain, dental pain, etc., chronic pains, such as neuropathic pain conditions of diabetic peripheral neuropathy, post-herpetic neuralgia and fibromyaigia, and inflammatory conditions such as osteoarthritis or rheumatoid arthritis, sequela to acute injury or trauma and cancen2related pain. This invention further provides a method of alleviation, inhibition, relief or treatment of arthritic and rheumatic disorders in a mammal, the method comprising administering to a mammal in need thereof a pHarmaceuticaJly effective amount of a chemical inhibitor of phospholipase enzymes, particularly phospholipase A2 enzymes, as defined herein and a pHarmaceutically effective amount of an anti- rheumatic agent. Combinations for the treatment of arthritic and rheumatic disorders may include commercially available anti-rheumatic agents such as, but not limited to, naproxen, which is commercially available in the form of EC-NAPROSyl]* delayed release tablets, NAPROSyl]*, ANAPROX* and ANAPROX* DS tablets and NAPROSyl]* suspension from Roche Labs, CELEBREX* brand of celecoxib tablets, VIOXX* brand of rofecoxib, CELESTONE* brand of betametHasone, CUPRAMINE* brand penidllamine capsules, DEPEN* brand titratabte penicHlamine tablets, DEPO MEDROL brand of methylprednlsolone acetate injectabte suspension, ARAVA™ leflunomide tablets, AZULFICHINE EN-tabs# brand of sulfasalazine delayed release tablets, FELDENE* brand piroxicam capsules, CATAFLAM* diclofenac potassium tablets, VOLTAREN* diclofenac sodium delayed release tablets, VOLTAREN*-XR diclofenac sodium extended release tablets, ENBREL* etanerecept products, and other commercially available antirheumatic agents. Also useful are GENGRAF™ brand cyclosprine capsules, RAPAMUNE* brand sirolimus products, NEORAL* brand cydosprine capsules or oral solution, IMURAN* brand azathioprine tablets or IV injection, INDOCIN* brand indometHatin capsules, oral suspension and suppositories, PEDIAPED* prednisolone sodium phospHate oral solution, PLAQUENIL* brand hydroxychkxoquine sulfate, PRELONE* brand prednisolone syrup, REMICADE* infUximab recombinant for IV injection, and SOLU-MEDROL* methylprednisolone sodium sucdnate for injection. Also useful in the combinations of this invention are gold compounds and products useful in the treatment of arthritis and rheumatic conditions, such as auranofin or Myl]CHRISYINE* gold sodium thiomalate injection. Each of these products may be administered according to the pHarmaceutically effective dosages and regimens known in the art, such as those described for the products in the Physicians' Desk Reference. 55 Edition, 2001, published by Medical Economics Co., Inc., Montvale, NJ The compounds of this invention may also be administered in the methods of this invention with analgesic and anti-inflammatory agents such as NSAIDs and aspirin and other salicylates. Examples of useful agents include ibuprofen (MOTRIN*, ADVIL*), naproxen (NAPROSyl]*), sulindac (CUNORIL*), diclofenac (VOtTAREN*), piroxicam (FELDENE*) ketoprofen (ORUDIS*), diflunisal (DOLOBID*), nabumetone (RELAFEN*), etodolac (LODINE*), oxaprozin (DAYPRO*), indometHacin (INDOCIN*), melicoxam (MOBICOX*), valdecoxib and eterocoxib. Aspirin is anti-inflammatory when given in high doses, otherwise it is just a pain killer like acetaminophen (TYLENOL*). Suitable cyclooxygenase 2 (COX-2) inhibitors for use with the methods of this invention include, but are not limited to, 2-(4-ethoxy-phenyl)-3-(4- metHanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine, CDC-501, celecoxib, COX-189, 4-(2-oxo-3i)henyl-2,3-dihydrooxa2ol-4-yf)benzenesulfonamide, CS-179, CS-502, D- 1367, darbufelone, DFP, DRF-4367, flosulide, JTE-522 (4-(4-cyclohexyl-2-methyf-5- oxazolyf)-2-fluorobenzenesulfonamide), L-745337, L-768277, L-776967, L-783003, L-791456, L-804600, meloxfcam, MK663 (etoricoxib), nimesulide. NS-398, parecoxib, 1-methylsulfonyl-4-(1H-dimethyl-4-(4-(4-fluorophenyl)cyclopenta-2,4-dien-3-yl)benzene 4-(1,5-Dihydro-iioro-7-methoxy-3-(trifluoromethyl)-(2)-benzothiopyran0(4,3- c)pyrazol-1-yl)benzenesutfonamide, 4,4-dimethyl-2-phenyl-3-(4- methylsulfonyl]phenyl) cydobutenone, 4-Amino-N-(4-(2-fluoro-5-trifluoromethyl)- thiazol-2-yl)-benzene sulfonamide, 1-(7-tert-butyl-2,3-dihydro-3.3-dimethyl-5-benzo- furanyfH-cydopropyl butan-1-one, PHarmaprojects No. 6089 (Kotobuki PHarmaceutical). RS-113472, RWJ-63556, S-2474, S-33516, SC-299, SC-5755, valdecoxib, Un28877, Un28813, Un28880. Further suitable COX-2 inhibitors for use according to the invention include parecoxib, MK663,4-(4-cyclohexy1-2-methyl-5- oxazolyl)-2-fluorobenzernesutfonamide (JTE-522). nimesulide, flosulide, DFP and 2- (4-ethoxy-phenyr)-3-4wnetnanesulfonyl-henyl)-yrazolo[1,54)]pyridazaine and their physiologically acceptable salts, esters or solvates. Such compositions are also useful in the treatment of menstrual cramps, preterm labor, tendonitis, bursitis, allergic neuritis, cytomegalovirus infection, apoptosis, including HIV- induced apoptosis, lumbago, liver disease including hepatitis. The methods are also useful in treating gastrointestinal conditions such as inflammatory bowel disease, Crohn's disease, gastritis, irritable bowel syl]drome and ulcrative colitis and for the prevention of treatment of cancer such as colorectal cancer. The compounds and compositions of the present invention are also useful for the prevention or treatment of benign and malignant turnorsmeoplasia including cancers such as colorectal cancer, brain cancer, bone cancer, epithelial cell-derived neopfasia (epithelial carcinoma) such as basal cell carcinoma, adenocaroinoma, gastrointestinal cancer, including lip cancer, mouth cancer, esophogeal cancer, small bowel cancer and stomach cancer, colon cancer, liver cancer, blacider cancer, pancreatic cancer, ovarian cancer, cervical cancer, lung cancer, breast cancer, and skin cancers, such as squamous cell and basal cell cancers, prostate cancer, renal cell carcinoma, and other known cancers tHat effect epithelial cells throughout the body. Neoplasias for which compositions of the invention are contemplated to be particularly useful are gastrointestinal cancer, Barrett's esopHagus, liver cancer, blacider cancer, pancreas cancer, ovarian cancer, prostatic cancer, cervical cancer, lung cancer, breast cancer, and skin cancer, such as squamous cell and basal cell cancers. The compounds and methods of this invention can also be used to treat the fibrosK occuring with radiation therapy. Such compositions can be used to treat subjects Having adenomatous polyps, including those with familial adenomatous polyposis (FAP). aciditionally, such compositions can be used to prevent polyps from forming in patients at risk of FAP. Compounds of this invention are useful j.i the treatment of cancers because of their anti-angiogenic effects. Further uses include treating inflammation in such diseases as vascular diseases, migraine headaches, periarteritis nodosa, thyroiditis, aplastic anemia, Hodgkin's disease, sderodoma, rheumatic fever, type I diabetes, neuromuscular junction disease including myasthenia gravis, white matter disease including multiple sclerosis, sarcoidosis, nephrotic syl]drome, Behcefs syl]drome, polymyl]sitis, gingivitis, nephritis, hypersensitivity, swelling occurring after injury including brain edema, myl]cardial ischemia, and the Hke. Also included are treatments of ophtHalmic diseases, such as retinitis, conjunctivitis, retinopathies, uveitis, ocular photophobia, and of acute injury to the eye tissue. Treatments herein of pulmonary and upper respiratory tract inflammation, such as tHat associated with viral infections and cystic fibrosis, and in bone resorption such as tHat accompanying osteoporosis. These compounds and compositions are useful for the treatment of certain central nervius system disorders, such as cortical dementias including Alzheimer's disease, neurodegeneration, and central nervous system damage resulting from stroke, ischemia and trauma. The compounds of this invention may also be useful in the treatment of Parkinson's disease. Methods of treating pain comprise administering to a mammal subject to such pain a pHarmaceuticalry effective amount of a compound of this invention alone or in combination with one or more aciditional pHarmaceutically effective agents for the treatment of pain or inflammation or the related underlying medical condition. Examples of drug agents which may be combined with the present compounds are analgesics, anti-angiogenic agents, anti-neoplastic agents, These compounds may also be combined with anti-epileptic compounds tHat Have pain alleviating properties, such as gabapentin and pregabaHn. One such combination method of this invention comprises administering to a mammal in need thereof a pHarmaceutically effective amount of a compound of this invention and a pHarmaceutically effective amount of a nontoxic N-methyt-D- aspartata (NMDA) receptor antagonist and/or an agent tHat blocks at least one major intracellular consequence of NMDA receptor activation. Examples of NMDA receptor antagonists useful in these methods include dextromethorpHan, dextrorpHan, amantadine and memantine, or the pHarmaceutically acceptable salts thereof. Another method herein of treating inflammation and inflammatory disorders comprises the co-administration to a mammal in need thereof of an inhibitor of induced nitric oxide syl]tHase with a compound of this invention. Administration of this combination is useful for prophylactic or therapeutic administration in a mammal experiencing or subject to an abnormally low level of nitric oxide syl]btHase (NOS) activity, particularly those subject to hypertension or an elevated risk of pulmonary hypertension, ischemic stroke, myl]cardial infarction, heart failure, progressive renal disease, thrombosis, reperfusion injury, or a nervous system degenerative disorder, such as Alzheimer's disease, or those chronically exposed to hypoxic conditions. The methods of this invention also include those for treating or preventing a neoplasia disorder in a mammal, including a human, in need of such treatment or prevention. The method comprises treating the mammal with a therapeutically effective amount of a compound of this invention in combination with an MMP inhibitor. These two components may further be optionally combined with one or more agents selected from an antiangiogenesis agent, an antineoplastic agent, an adjunctive agent an immunotherapeutic agent, an analgesic agent; and/or a radiotherapeutic agent. One such multiple component therapy comprises administering to the mammal in need thereof a compound of this invention, a matrix metalloproteinase inhibitor and an antineoplastic agent The methods and combinations of this invention may be used for the treatment or prevention of neoplasia disorders including acral lentiginous melanoma, actinic keratoses, adenocarcinoma, adenoid cycstic carcinoma, adenomas, adenosarcoma, adenosquamous carcinoma, astrocytic tumors, barthoHn gland carcinoma, basal cell carcinoma, bronchial gland carcinomas, capillary, cardnoids, carcinoma, cardnosarcoma, cavernous, cholangiocarcinoma, chondosarcoma, choriod plexus papOloma/carcinoma, dear cell carcinoma, cystadenoma, endodermal sinus tumor, endometrial hyperplasia, endometriaJ stromal sarcoma, endometrioid adenocardnoma, ependymai, epltheloid, Ewing's sarcoma, fibrolamellar, focal nodular hyperplasia, gastrinoma, germ cell tumors, glioblastoma, glucagonoma, hemangiblastomas, hemangioendothefioma, hemangiomas, hepatic adenoma, hepatic adenomatosis, hepatocelluJar carcinoma, insuRnoma, intaepttheHal neoplasia, interepithelial. squamous cell neoplasia, invasive squamous cell carcinoma, large cell carcinoma, leiomyl]sarcoma, ientigo maUgna melanomas, malignant melanoma, malignant mesotheBal tumors, meduUoblastoma, medulloepithetioma, melanoma, meningeal, mesothelial, metastatic carcinoma, mucoepidermoid carcinoma, neuroblastoma, neuroepithelial adenocarcinoma nodular melanoma, oat cell carcinoma, oligodendroglial, osteosarcoma, pancreatic porypeptide, papillary serous adenocarcinoma, pineal cell, pituitary tumors, plasmacytoma, pseudosarcoma, pulmonary blastema, renal cell carcinoma, retinoblastoma, rHabdomyl]sarcoma, sarcoma, serous carcinoma, small cell carcinoma, soft tissue carcinomas, somatostatin-secreting tumor, squamous carcinoma, squamous cell carcinoma. subrpesothelial, superficial spreading melanoma, undlfferentiated carcinoma, uveal melanoma, verrucous carcinoma, vipoma, well differentiated carcinoma, and Wilm's tumor. Antineoplastic agents useful in the combination therapies herein include anastrozote, calcium carbonate, capecHabine, carboplatin, cisplatin, Cell Pathways CP-461, docetaxel, doxorubicin, etoposide, fiuorouracil, fluoxymestrine, gemdtabine, goseretin, irinotecan, ketoconazole, letrozol, leucovorin, levamisole, megestrol, mitoxantrone, paclitaxel, raloxifene, retinoic acid, tamoxffen, thiotepa, topotecan, toremifene, vinorelbine, vinblastine, vincristine, selenium (selenomethionine), ursodeoxycholic acid, sulindac sutfbne, exemestane and eflomithine (DFMO), 1-{4- (2-Azepaiv1yl-ethoxy)-benzyl]-2-4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol(also known as TSE-424) and 2-(4-Hydroxy-phenyI)-3-methyl-1-{4-(2-piperidin-1-yl- ethoxy)-benzyl]-1H-indol-5-ol (also known as ERA-923). This invention also includes methods of utilizing the compounds herein in combination with a protefnaceous interieukin-1 inhibitor, such as an IL-1 receptor antagonist (IL-Jra), for preventing or treating inflammatory diseases in a mammal. Acute and chronic interfeukin-1 (IL-1)-mediated inflammatory diseases of interest in these methods include, but is not limited to acute pancreatitis; ALS; Alzheimer's disease; cachexia/anorexJa; asthma; atherosclerosis; chronic fatigue syl]drome, fever; diabetes (e.g., insulin diabetes); glomerulonephritis; graft versus host rejection; hemohorragic shock; hyperalgesia, inflammatory bowel disease; inflammatory conditions of a joint, including osteoarthritis, psoriatic arthritis and rheumatoid arthritis; techemic injury, including cerebral ischemia (e.g., brain injury as a result of trauma, epilepsy, hemorrHage or stroke, each of which may lead to neurodegeneration); lung diseases (e.g., ARDS); multiple myeloma; multiple sclerosis; myelogenous (e.g., AML and CML) and other leukemias; myl]pathies (e.g., muscle protein metabolism, esp. in sepsis); osteoporosis; Parkinson's disease; pain; pre-term labor; psoriasis; reperfusion injury; septic shock; side effects from radiation therapy, temporal mandibuiar joint disease, tumor metastasis; or an inflammatory condition resulting from strain, sprain, cartilage damage, trauma, orthopedic surgery, infection or other disease processes. This invention also provides a method of administering one or more of the compounds of this invention to a female in need thereof to substantially prevent or reducing cHanges in the female's reproductive system associated with onset or continuation of labor. Also provided is a method of substantially preventing or reducing uterine contractility either occurring during pregnancy or associated with menorrHagia. These methods may optionally include coadministration of a compound of this invention with a progestogen, a progestin or a progestational agent. Each of the methods of this invention comprises administering to a mammal in need of such treatment a pHarmaceuticaJly or therapeutically effective amount of a compound of this invention. In the instances of combination therapies described herein, it will be understood the administration further includes a pHarmaceutically or therapeutically effective amount of the second pHarmaceutical agent in question. The second or aciditional pHarmacological agents described herein may be administered in the doses and regimens known in the art. The compounds of this invention may also be used in comparable veterinary methods of treatment, particularly for the veterinary treatment, inhibition or alleviation of inflammation and pain. These methods will be understood to be of particular interest for companion mammals, such as dogs and cats, and for use In farm mammals, such as cattle, horses, mules, donkeys, goats, hogs, sheep, etc. These methods may be used to treat the types of inflammation and pain experienced in veterinary medicine including, but not Knitted to, pain and inflammation associated with arthritis, joint imperfections, developmental Joint defects, such as Np dysplasia, tendonitis, suspensary ligament inflammation, laminrtis, curb and bursitis, or pain or inflammation associated with surgery, accident, trauma or disease, such as Lyme Disease. These compounds may also be used in the treatment of Inflammation of the air passages, such as in conditions of asthma, laryl]gitis, trachertis, bronchitis, rhinitis and pHaryl]gitis The compounds of this invention may also be used in comparable veterinary methods of treatment, particularly for the veterinary treatment, inhibition or alleviation of inflammation and pain associated with asthmatic conditions. These methods will be understood to be of particular interest for companion mammals, such as dogs and cats, particularly with feline asthma. These compounds may also be used Ni the treatment of inflammation of the air passages, such as in conditions of asthma, laryl]gitis, tracheitis, bronchitis, rhinitis and pHaryl]gitis The compounds of this invention may be used in the veterinary treatment of asthma and asthmatic conditions in combination with other treatments for asthma, such as feline asthma, including oral or injectable steroids, Cyproheptadine, Cydosporin A, or AntMnterleukin-5 Antibody. Each of these veterinary methods comprises administering to the mammal in need thereof a pHarmaceutically effective amount of a compound of this invention, or a pHarmaceutically acceptable salt form thereof. The compounds of this invention may be used for human or veterinary methods in conjunction with other medicaments or dietary supplements known in the art for the treatment, inhibition or alleviation of inflammation or pain. These may include aspirin (including buffered aspirin, aspirin with Maalox and enteric coated aspirin), COX-2 inhibitors, such as celecoxib, non- acetylated carboxylic acids, such as magnesium salicylate, salicylamide or sodium salicylate, acetic acids, such as dodofenac or etodolac, propionic acids, such as buprofen. naproxen (available in NAPROSyl]* and EQUIPROXEN* brands), ketoprofen, RIMAOYL*(carprofen), flunbdn meglumine, fenamfc acids, such as tolfenamic acid, mefanamlc acid, medofenamic acid (ARQUEL*) or niflumic acid, enolic acids, such as oxyphenbutazone, phenylbutazone, piroxicam or dipyrone, or non-acidic compounds Hke nabumetone. Also used in veterinary applications are dimethylsulfoxide (DMSO), orgotein (such as PALOSEIN* brand of orgotein), por/sutfated glycosaminoglycans or PS-GAGs (such as ADEQUAN* brand potysulfated glycosaminoglycan), hyaluronic acid and its natural and syl]thetic analogues. Ketorolac trimetHamine (such as the TORADOL* brand). FELDENE* (piroxicam), or METACAM* (meloxjcam). Dietary supplements used in human or veterinary appfications indude glucosamines, chondrottin sulfate, methylsulfonylmetHane (MSM), and omega 3 fatty acids, and other cold water fish oils. The compounds and methods of this invention may also be used in conjunction with human or veterinary physical therapy, massage, chiropractic and accupuncture treatments and regimens. Each of these medicaments and dietary supplements may be administered to the mammal in question using regimens and effective dosages known in the art. We Claim : 1. A compound of the formula: wherein: R is selected from the formulae -(CH2)n-A, -(CH2)n-S-A, or -(CH2)n-O-A, wherein A is selected from the moieties: wherein B and C are independently selected from phenyl, pyridinyl, pyrimidinyl, furyl, thienyl or pyrrolyl groups, each optionally substituted by from 1 to 3, preferably 1 to 2, substituents selected independently from H, Halogen, -CN, -CHO, -CF3, -OCF3, -OH, - C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2, or by a 5- or 6-membered heterocyclic or heteroaromatic ring containing 1 or 2 heteroatoms selected from O, N or S; or n is an integer from 0 to 3; ni is an integer from 1 to 3; n2 is an integer from 0 to 4; n3 is an integer from 0 to 3; n4 is an integer from 0 to 2; X, is selected from a chemical bond, -S-, -O-, -S(O)-, -S(O)2-, -NH-, - NHC(O)-, R1 is selected from C1-C6 alkyl, C1-C6 fluorinated alkyl, C3-C6 cycloalkyl, tetrahydropyranyl, camphoryl, adamantyl, CN, -N(C1-C6 alkyl)2, phenyl, pyridinyl, pyrimidinyl, furyl, thienyl, naphthyl, morpholinyl, triazolyl, pyrazolyl, piperidinyl, pyrrolidinyl, imidazoiyl, piperizinyl, thiazolidinyl, thiomorpholinyl, tetrazole, indole, benzoxazole, benzofuran, imidazolidine-2-thione, 7,7,dimethyl-bicyclo[2.2.1]heptan-2- one, benzo[1,2,5]oxadiazole, 2-oxa-5-aza-bicyclo[2.2.1]heptane, piperazin-2-one or pyrrolyl groups, each optionally substituted by from 1 to 3, preferably 1 to 2, substituents independently selected from H, Halogen, -CN, -CHO, -CF3, OCF3,-OH, -C1-C6 alkyl, d- C6 alkoxy, -NH2,-N(C1-C6 alkyl)2, -NH(CrC6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2, -SO2(Cr C3 alkyl), -SO2NH2, -SO2NH(C1-C3 alkyl), -SO2N(C1-C63 alkyl)2) -COOH, -CH2-COOH, - CH2-N(C1-C6 alkyl), -CH2-N(C1-C6 alkyl)2, -CH2-NH2, pyridine, 2-methyl-thiazole, morpholino, 1-chloro-2-methyl-propyl, -C1-C6thioalkyl, phenyl (further optionally substituted with Halogens), benzyloxy, (C1-C3 alkyl)C(O)CH3, (C1-C63 alkyl)OCH3, C(O)NH2, or R2 is a ring moiety selected from phenyl, pyridinyl, pyrimidinyl, furyl, thienyl or pyrrolyl groups, the ring moiety being substituted by a group of the formula -(CH2)n4- CO2H or a pHarmaceutically acceptable acid mimic or mimetic selected from the group consisting of: wherein Ra is selected from -CF3, -CH3, phenyi, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, d- C6 alkoxy, C1-C6 thioalkyl, -CF3, Halogen, -OH, or -COOH; Rb is selected from -CF3) - CH3, -NH2, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -CF3l Halogen, -OH, or -COOH; and Rc is selected from -CF3 or C1-C6 alkyl, and the ring moiety or R2 is also optionally substituted by 1 or 2 aciditional substituents independently selected from H, Halogen, -CN, -CHO, -CF3, -OCF3, -OH, -CrC6 alkyl, Cr C6 alkoxy, CrC6 thioalkyl, -NH2, -N(CrC6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; . R3 is selected from H, Halogen, -CN, -CHO, -CF3, -OCF3j -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; R4 is selected from H, Halogen, -CN, -CHO, -CF3, -OCF3j -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(CrC6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), - NO2, -N-C(O)-N(C1-C63 alkyl)2, -N-C(O)-NH(C1-C63 alkyl), -N-C(O)-O-(C1-C63 alkyl), -SO2- C1-C6 alkyl, -S-C3-C6 cycloalkyl, -S-CH2-C3-C6 cycloalkyl, -SO2-C3-C6 cycloalkyl,, -SO2- CH2-C3-C6 cycloalkyl, C3-C6 cycloalkyl, -CH2-C3-C6 cycloalkyl, -O-C3-C6 cycloalkyl,, -O- CH2-C3-C6 cycloalkyl, phenyl, benzyl, benzyloxy, morpholino or other heterocycles such as pyrrolidino, piperidine, piperizine, furan, thiophene, imidazole, tetrazole, pyrazine, pyrazolone, pyrazole, imidazole, oxazole or isoxazole, the rings of each of these R4 groups each being optionally substituted by from 1 to 3 substituents selected from the group of H, Halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2, -SO2(C1-C63 alkyl), -SO2NH(C1-C63 alkyl), -SO2N(C1-C63 alkyl)2, or OCF3; or a pHarmaceutically acceptable salt form thereof. 2. A compound as claimed in Claim 1 wherein R is -(CH2)n-A. 3. A compound as claimed in Claim 1 or Claim 2 wherein n is 0. 4. A compound as claimed in any one of Claims 1 to 3 wherein B and C are each independently unsubstituted phenyl, pyridinyl, pyrimidinyl, furyl, thienyl or pyrrolyl groups. 5. A compound as claimed in any one of Claims 1 to 4 wherein A is the moiety: 6. A compound as claimed in any one of Claims 1 to 5 wherein R3 is selected from H, Halogen, -CN, -CHO, -CF3) -OH, -CrC6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2l-N(C1-C6 alkyl)2l -NH(CrC6 alkyl), -N-C(O)-(CrC6 alkyl), or -NO2. 7. A compound as claimed in any one of Claims 1 to 6 wherein FU is selected from H, Halogen, -CN, -CHO, -CF3) -OH, -CrC6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2,-N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(CrC6 alkyl), -NO2, morpholino, pyrrolidino, piperidine, piperazine, furan, thiophene, imidazole, tetrazole, pyrazine, pyrazolone, pyrazole, imidazole, oxazole or isoxazole. 8. A compound as claimed in any one of Claims 1 to 7 wherein R3 and R4 are bonded to the 5 and 6 positions of the indole ring. 9. A compound as claimed in any one of Claims 1 to 8 wherein n3 is 1. 10. A compound as claimed in any one of Claims 1 to 9 wherein X2 is O, -SO2-, -NH- or -CH2-. 11. A compound as claimed in any one of Claims 1 to 10 wherein R2 is a moiety selected from the group of: or a pHarmaceutically acceptable acid mimic or mimetic, wherein n4 is 0-2 and R8 and R9 are independently selected from H, Halogen, -CN, -CHO, -CF3l -OH, - C1-C6 alkyl, CrC6 alkoxy, CrC6 thioalkyl, -NH2, -N(CrC6 alkyl)2) -NH(CrC6 alkyl), -N- C(O)-(CrC6 alkyl), on2NO2. 12. A compound as claimed in any one of Claims 1 to 11 wherein n4 is 0. 13. A compound as claimed in Claim 11 wherein the pHarmaceutically acceptable acid mimics or mimetics are those wherein R2 is selected from the group consisting of: wherein Ra is selected from -CF3, -CH3, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from CrC6 alkyl, Cr C6 alkoxy, C1-C6 thioalkyl, -CF3, Halogen, -OH, or -COOH; Rb is selected from -CF3) - CH3, -NH2, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -CF3, Halogen, -OH, or -COOH; and Rc is selected from -CF3 or C1-C6 alkyl. 14. A compound as claimed in any one of Claims 11 to 13 wherein -(CH2)n4- CO2H or the pHarmaceutically acceptable acid mimic or mimetic is in the 4-position. 15. A compound as claimed in any one of Claims 1 to 14 wherein rii is 1 or 2. 16. A compound as claimed in any one of Claims 1 to 15 wherein n2 is 0,1 or 2. 17. A compound as claimed in any one of Claims 1 to 14 wherein - and n2 are both 1. 18. A compound as claimed in any one of Claims 1 to 17 wherein X- is selected from a chemical bond, -S-, -O-, -NH- or -N(C1-C63 alkyl)-. 19. A compound as claimed in any one of Claims 1 to 18 wherein Rt is selected from C1-C6 alkyl, C3-C6 cycloalkyl, phenyl, pyridinyl, naphthyl, tetrazole, each optionally substituted by from 1 to 3 substituents independently selected from H, Halogen, -CN, -CHO, -CF3, OCF3,-OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2, -SO2(C1-C3 alkyl), -SO2NH2, -SO2NH(C1-C3 alkyl), -SO2N(C1-C63 alkyl)2, -COOH, -CH2-COOH, -CH2-N(C1-C6 alkyl), -CH2-N(C1-C6 alkyl)2, -CH2-NH2 -C1-C6thioalkyl, phenyl (further optionally substituted with Halogens), benzyloxy, -(C1-C63 alkyl)C(O)CH3, -(C1-C63 alkyl)OCH3 and -C(O)NH2. 20. A compound as claimed in any one of Claims 1 to 18 wherein Rt Has the formula: wherein R5, R6 and R6 are independently selected from H, Halogen, -CN, -CHO, - CF3, OCF3,-OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N- C(O)-(C1-C6 alkyl) and-NO2. 21. A compound according to Claim 1 Having formulae (II) or (III): wherein n1, n2, n3, n4, X- X2, R1f R2) R3 and R4 are as defined in Claim 1, or a pHarmaceutically acceptable salt thereof. 22. A compound as claimed in Claim 21 wherein n3 = 1. 23. A compound as claimed in Claim 21 or Claim 22 wherein R2 is phenyl substituted by a group of the formula ~(CH2)n4-CO2H; and optionally substituted by 1 or 2 aciditional substituents independently selected from H, Halogen, -CN, -CHO, -CF3, -OH, - C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N- C(O)-(C1-C6 alkyl) and -NO2. 24. A compound as claimed in Claim 1 Having the formulae (IV) or (V): wherein: rii is an integer from 1 to 3; n2 is an integer from 1 to 3; R5, R6 and Re are independently selected from H, Halogen, -CN, -CHO, -CF3) - OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6e alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; X1 is selected from a chemical bond, -S-, -O-, -NH- on2N(C1-C3 alkyl)-; X2 is selected from -O-, -SO2- or -CH2-; R2 is a moiety selected from the group of: R8 and R9 are independently selected from H, Halogen, -CN, -CHO, -CF3, -OH, - C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2l -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alky)), or -NO2; n4 is an integer from 0 to 2; R3 is selected from H, Halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2,-N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; and R4 is selected from H, Halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2l -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2) morpholino or other heterocycles such as pyrrolidino, piperidine, piperazine, furan, thiophene, imidazole, tetrazole, pyrazine, pyrazolone, pyrazole, imidazole, oxazole or isoxazole; or a pHarmaceutically acceptable salt form thereof. 25. A compound according to Claim 1 Having the formulae (VI) or (VII): wherein: Xi is selected from a chemical bond, -S-, -O-, -NH- on2N(C1-C3 alkyl)-; X2 is selected from -O-, -SO2-, or -CH2-; R3 is selected from H, Halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2)-N(C1-C6 alkyl)2) -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; and R4 is selected from H, Halogen, -CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2, morpholino or other heterocycles such as pyrrolidino, piperidine, piperizine furan, thiophene, imidazole, tetrazole, pyrazine, pyrazolone, pyrazole, imidazole, oxazole or isoxazole; ni is an integer from 1 to 2; n2 is an integer from 1 to 2; R5, R6 and R& are independently selected from H, Halogen, -CN, -CHO, -CF3l OCF3,-OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2,-N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)- (C1-C6 alkyl), or -NO2; R8 and R9 are independently selected from H, Halogen, -CN, -CHO, -CF3, -OH, - C1-C6 alkyl, C1-C6 alkoxy, -NH2,-N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; or a pHarmaceutically acceptable salt form thereof. 26. A compound according to Claim 25 of formulae (VI) or (VII) wherein: ni is 1 and n2 is 1. 27. A compound according to any one of claims 1 to 26 wherein X, is a chemical bond. 28. A compound according to Claim 1 which is selected from the group consisting of: 4-[2-(1 -Benzhydryl-2-{2-[(benzylsulfonyl) amino]ethyl}-5-chloro-1 H-indol-3- yl)ethoxy]benzoic acid; 4-[2-(1-Benzhydryl-5-chloro-2-{2-[(isopropylsulfonyl)amino]ethyl}-1H-indol-3- yl)ethoxy]benzoic acid; 4-[2-(1 -Benzhydryl-2-{2-[(butylsulfonyl) amino]ethyl}-5-chloro-1 H-indol-3- yl)ethoxy]benzoic acid; 4-{2-[1 -Benzhydryl-5-chloro-2-(2-{[(1 -methyl-1 H-imidazol-4- yl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethoxy}benzoic acid; and 4-{2-[1-Benzhydryl-2-(2-{[(5-bromo-6-chloro-3-pyridinyl)sulfonyl]amino}ethyl)-5- chloro-1 H-indol-3-yl]ethoxy}benzoic acid; 4-[2-(1-Benzhydryl-5-chloro-2-{2-[({[(1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1- yl]methyl}sulfonyl)amino]ethyl}-1H-indol-3-yl)ethoxy]benzoicacid; 4-(2-{1-Benzhydryl-5-chloro-2-[2-({[(methylsulfonyl)methyl]sulfonyl}amino) ethyl]- 1 H-indol-3-yl}ethoxy)benzoic acid; 4-(2-{1-Benzhydryl-5-chloro-2-[2-({[(2-(1-naphthyl)ethyl]sulfonyl}amino)ethyl]-1H- indol-3-yl}ethoxy)benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-{2-[({2-nitrobenzyl}-sulfonyl)amino]ethyl}-1H-indol- 3-yl)ethoxy]benzoic acid; and 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}-ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(3,5-dichlorobenzyl)sulfonyl]amino}-ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-(2-{1-Benzhydryl-5-chloro-2-(2-({[(3-(trifluoromethyl)benzyl]sulfonyl}- amino)ethyl]-1 H-indol-3-yl}ethoxy)benzoic acid; 4-(2-{1-Benzhydryl-5-chloro-2-(2-({[(4-(trifluoromethyl)benzyl]sulfonyl}- amino)ethyl]-1 H-indol-3-yl}ethoxy)benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(4-fluorobenzyl)sulfonyl]amino}-ethyl)-1H-indol- 3-yl]ethoxy}benzoic acid; and 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(4-chlorobenzyl)sulfonyl]amino}-ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 2-(2-{[(2-Aminobenzyl)sulfonyl]amino}ethyl)-4-{2-[1-benzhydryl-5-chloro-1H-indol- 3-yl]ethoxy}benzoic acid; 4-{2-[1 -Benzhydryl-5-chloro-2-(2-{[(dimethylamino)sulfonyl]amino}ethyl)-1 H-indol- 3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(3,4-difluorobenzyl)sulfonyl]amino}-ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(2-naphthylmethyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; and 3-({[(2-{1-benzhydryl-3-[2-(4-carboxyphenoxy)ethyl]-5-chloro-1H-indol-2- yl}ethyl)amino]sulfonyl}methyl)benzoicacid; 4-(2-{1 -benzhydryl-5-chloro-2-[2-({[(E)-2-phenylethenyl]sulfonyl}amino) ethyl' 1H indol-3-yl}ethoxy)benzoic acid; 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(trifluoromethyl)sulfonyl]amino}ethyl)-1H-indol- 3-yl]ethoxy}benzoic acid; 4-[2-(1-benzhydryl-5-chloro-2-{2-[(cyclopropylsulfonyl)amino]ethyl}-1H-indol-3- yl)ethoxy]benzoic acid; 4-(2-{1-benzhydryl-2-[2-({[3,5-bis(trifluoromethyl)benzyl]sulfonyl}amino)ethyl]-5- chloro-1 H-indol-3-yl}ethoxy)benzoic acid; and 2-{[(2-{1-benzhydryl-3-[2-(4-carboxyphenoxy)ethyl]-5-chloro-1H-indol-2- yl}ethyl)amino]sulfonyl}benzoicacid; 4-[2-(1-benzhydryl-5-chloro-2-{2-[(2-naphthylsulfonyl)amino]ethyl}-1H-indol-3- yl)ethoxy]benzoic acid; 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(3,5-dichlorophenyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(3,4-dichlorophenyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(2,3-dichlorobenzyl)sulfonyl]amino}ethyl)-1H indol-3-yl]ethoxy}benzoic acid; and 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(2,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(2,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-benzhydryl-5-chloro-2- (2-{[(4-chloro-2-nitrobenzyl)sulfonyl]amino}ethyl)- 1 H-indol-3-yl]ethoxy}benzoic acid; 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)amino]ethyl}-5-morpholin-4-yl-1H-indol- 1 ?yi)ethoxy]benzoic acid; * 4-{2-[1 -Benzhydryl-5-chloro-2-(2-{[(2-cyanobenzyl)sulfonyl]amino}ethyl)-1 H-indol- 3-yl]ethoxy}benzoic acid; and 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(2-cyanobenzyl)sulfonyl]amino}ethyl)-1H-indol- 3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(3-cyanobenzyl)sulfonyl]amino}ethyl)-1H-indol- 3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(4-cyanobenzyl)sulfonyl]amino}ethyl)-1H-indol- 3-yl]ethoxy}benzoic acid; 4-(2-{1-Benzhydryl-5-chloro-2-[2-({[4-(1piperidinylsulfonyl)benzyl]sulfonyl} amino)ethyl]-1 H-indol-3-yl}ethoxy)benzoic acid; 4-(2-{2-[2-({[4-(Aminosulfonyl)benzyl]sulfonyl}amino)ethyl]-1-benzhydryl-5-chloro- 1 H-indol-3-yl}ethoxy)benzoic acid; and 4-(2-{1-Benzhydryl-5-chloro-2-[2-(4-metHanesulfonyl-phenylmetHane sulfonylamino) -ethyl]-1H-indol-3-yl}-ethoxy)-benzoic acid; 4-(2-{1-Benzhydryl-5-chloro-2-[2-(4-diethylsulfamoyl-phenylmetHane sulfonylamino)-ethyl]-1 H-indol-3-yl}-ethoxy)-benzoic acid; 4-{3-[1-Benzhydryl-5-chloro-2-(2-phenylmetHanesulfonylamino-ethyl)-1H-indol-3- yl]-propyl}-benzoic acid; 4-{3-[1-benzhydryl-5-chloro-2-(2-{[(3,5-dichlorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyl}benzoic acid; 4-{3-[1-benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyl}benzoic acid; 4-[2-(1-benzhydryl-5-chloro-2-(2-[(methylsulfonyl)amino]ethyl)-1H-indol-3- yl]ethoxy}benzoic acid; 4-[2-(1-benzhydryl-5-chloro-2-{2-[(phenylsulfonyl)amino]ethyl}-1H-indol-3- yl]ethoxy}benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-({[3-(trifluoromethyl)benzyl]sulfonyl}amino)ethyl]- 1 H-indol-3-yl}ethoxy)benzoic acid; 2-{[(2-{[(2-{1-benzhydryl-3-[2-(4-carboxyphenoxy)ethyl]-5-chloro-1H-indol-2- yl}ethyl)amino]sulfonyl}ethyl)amino]carbonyl}benzoicacid; 4-{2-[{1 -benzhydryl-5-chloro-2-(2-{[(3-(pyridinylmethyl) sulfonyl]amino}ethyl)-1 H- indol-3-yl]ethoxy}benzoic acid; and 4-{2-[{1 -benzhydryl-5-chloro-2-(2-{[(4-(pyridinylmethyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]ethoxy}benzoic acid; / , 4-{2-[{1 -benzhydryl-5-chloro-2-(2-{[(2-(pyridinylmethyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]ethoxy}benzoic acid; 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(2,6-dimethylbenzyl)sulfonyl] amino}ethyl)-1 H- indoly-3-yl]propyl}benzoic acid; 4-{2-[1 -benzhydryl-5-chloro-2-(2-{[(cyclohexylmethyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(4-nitrobenzyl)sulfonyl]amino}ethyl)-1H-indol-3- yl]ethoxy}benzoic acid; and 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(3-nitrobenzyl)sulfonyl]amino}ethyl)-1H-indol-3- yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-{2-[({2-nitrobenzyl}-sulfonyl)amino]ethyl}-1H-indol- 3-yl) propyl]benzoic acid; 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(4-fluorobenzyl)sulfonyl]amino}ethyl)-1 H- indol- 3-yl]propyl}benzoic acid; 4-(3-{1 -benzhydryl-5-chloro-2-[2-({[4- (trifluoromethyl)benzyl] sulfonylamino) ethyl]-1 H-indol-3-yl}propyl)benzoic acid; 4-(3-{1 -benzhydryl-5-chloro-2-[2-({[3- (trifluoromethyl)benzyl]sulfonyl} amino) ethyl]-1H-indol-3-yl}propyl)benzoic acid; and 4-{3-[1-benzhydryl-5-chloro-2-(2-{[(4-chlorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyl}benzoic acid; 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(2-pyridinylmethyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]propyl}benzoic acid; 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(3-pyridinylmethyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]propyl}benzoic acid; 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(4-pyridinylmethyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]propyl}benzoic acid; 4-{3-[1-benzhydryl-5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyl}benzoic acid; and 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(3-nitrobenzyl)sulfonyl]amino}ethyl)-1 H- indol- 3-yl]propyl}benzoic acid; 4-{3-[1-benzhydryl-5-chloro-2-(2-{[(3-chlorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyl}benzoic acid; 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(2,5-dichlorobenzyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]propyl}benzoic acid; „ 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(3-methoxybenzyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]propyl}benzoic acid; 4-{3-[2-(2-{[(2-aminobenzyl)sulfonyl]amino}ethyl)-1-benzhydryl-5-chloro-1H-indol- 3-yl]propyl}benzoic acid; and 4-{3-[1-Benzhydryl-5-chloro-2-(2-{[(2-methylbenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]propyl}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(4-trifluorometoxybenzyl)sulfonyl]amino} ethyl)- 1 H-indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(2-fluoro-6-nitrobenzyl)sulfonyl]amino}ethyl)- 1 H-indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(2-dichlorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(2,6-difluorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; and 4-(2-{1-benzhydryl-5-chloro-2-[2-({[(6-chloro-3-pyridinyl)methyl]sulfonyl}amino) ethyl]-1 H-indol-3-yl}ethoxy)benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-({[(5,6-dichloro-2-[pyridinyl)methyl] sulfonylamino)ethyl]-1 H-indo!-3-yl}ethoxy)benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(3-methoxybenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(3,5-dimethylbenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{f(2-methylbenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; and 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(2,6-dichlorobenzyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-(2-{1-benzhydryl-5-chloro2[2({[(phenylsulfanyl)methyl]sulfonyl}amino) ethyl]-1 H- indol-3-yl}ethoxy)benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-(2,6-dimethyl-phenylsulfany!metHane sulfonylamino)-ethyl]- ]-1H-indol-3-yl} -ethoxy)-benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-(2-methoxy-pheny]sulfanylmetHane su!fonylamino)-ethyl]- ]-1 H-indol-3-yl} -ethoxy)-benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-(2-ch!oro-6-methyl-phenylsulfany]metHane sulfonylamino)- ethyl]- ]-1 H-indol-3-yl} -ethoxy)-benzoic acid; and 4-(2-{1-benzhydryl-5-chloro-2-[2-(3,5-dichloro-phenylsulfanylmetHane sulfonylamino)- ethyl]- ]-1 H-indol-3-yl} -ethoxy)-benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-(3,4-dimethoxy-phenylsulfanylmetHane sulfonylamino)- ethyl]- ]-1 H-indol-3-yl} -ethoxy)-benzoic acid; 4-(2-{1-Benzhydryl-5-chloro-2-[2-(2-morpholin-4-yletHanesulfonylamino)-ethyl]- 1 H-indol-3-yl}-ethoxy)-benzoic acid; 4-(2-{1 -Benzhydryl-5-chloro-2-[2-(2-pyrazol-1 -yl-etHanesulfonylamino)-ethyl]-1 H- indol-3-yl}-ethoxy)-benzoic acid; 4-(2-{1-Benzhydryl-5-chloro-2-[2-(2-phenylamino-etHanesulfonylamino)-ethyl]-1H- indol-3-yl}-ethoxy)-benzoic acid; and 4-(2-{1-benzhydryl-5-chloro-2-[2-({[2-(1,4-dioxa-8-azaspiro[4.5]dec-8- yl)ethyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}ethoxy)benzoicacid; 4-[2-(1-benzhydryl-5-chloro-2-{2-[({2-[4-(2-pyridinyl)-1-piperazinyl]ethyl} sulfonyl)amino]ethyl}-1 H-indol-3-yl)ethoxy]benzoic acid; 4-(2-{1 -benzhydryl-5-chloro-2-[2-({[2-(1 H-1,2,4-triazol-1 - yl)ethyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}ethoxy)benzoicacid; 4-(2-{1 -benzhydryl-5-chloro-2-[2-({[2-(3,5-dimethyl-1 H-pyrazol-1 -yl)ethyl]sulfonyl} amino)ethyl]-1 H-indol-3-yl}ethoxy)benzoic acid; 4-(2-{1 -benzhydryl-5-chloro-2-[2-({[2-(3-methyl-1 H-pyrazol-1 - yl)ethyl]sulfonyl}amino) ethyl]-1H-indol-3-yl}ethoxy)benzoic acid; and 4-(2-{1 -benzhydryl-5-chloro-2-[2-({[2-(4-methyl-1 H-pyrazol-1 - yl)ethyl]sulfonyl}amino) ethyl]-1 H-indol-3-yl}ethoxy)benzoic acid; 4-[2-(1-benzhydryl-5-chloro-2-{2-[({2-[(2R,6S)-2,6-dimethyl-1-piperidinyl]ethyl} sulfonyl)amino]ethyl}-1 H-indol-3-yl)ethoxy]benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-({[2-(2-thioxo-1-imidazolidinyl)ethyl]sulfonyl} amino)ethyl]-1 H-indol-3-yl}ethoxy)benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-({[2-(1,3-thiazolidin-3-yl)ethyl]sulfonyl} amino)ethyl]-1 H-indol-3-yl}ethoxy)benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-(2- [1,2,3]triazol-1-yl-etHanesulfonylamino)- ethyl]-1H-indol-3-yl}ethoxy)benzoic acid; and - 4-(3-{1-Benzhydryl-5-chloro-2-[2-(2-morpholin-4-yl-etHanesulfonylamino)-ethyl]- 1 H-indol-3-yl}-propyl)-benzoic acid; 4-[3-(1-Benzhydryl-5-chloro-2-{2-[2-(2,6-dimethyl-piperidin-1-yl)-etHanesulfonyl amino]-ethyl}-1 H-indol-3-yl)-propyl]-benzoic acid; - 4-[3-(1 -Benzhydryl-5-chloro-2-{2-[2-(3,5-dimethyl-pyrazol-1 -yl)-etHanesulfonyl amino]-ethyl}-1 H-indol-3-yl)-propyl]-benzoic acid; 4-(2-{1 -benzhydryl-5-chloro-2-[2-(2- tetrazol-2-yl-etHanesulfonylamino)-ethyl]-1 H- indol-3-yl}ethoxy)benzoic acid; 4-(2-{1 -benzhydryl-5-chloro-2-[2-(2- tetrazol-1 -yl-etHanesulfonylamino)-ethyl]-1 H- indol-3-yl}ethoxy)benzoic acid; and 4-{2-[1-BenzhydryI-6-chloro-2-(2-phenylmetHanesulfonylamino-ethyl)-1H-indol-3- yl]-ethoxy}-benzoic acid; 4-(2-{1-Benzhydryl-6-chloro-2-[2-(3,4-dichloro-phenylmetHanesulfonylamino)- ethyl]-1 H-indol-3-yl}-ethoxy)-benzoic acid; 4-(2-{1-Benzhydryl-6-chloro-2-[2-(3,5-dichloro-phenylmetHanesulfonylamino)- ethyl]-1 H-indol-3-yl}-ethoxy)-benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(2-cyanobenzyl)sulfonyl]amino}ethyl)-1H-indol- 3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(tetrahydro-2H-pyran-2-ylmethyl)sulfonyl] amino}ethyl)-1H-indol-3-yl]ethoxy}benzoic acid; and 4-{2-[1-Benzhydryl-2-(2-{[(1,3-benzoxazol-2-ylmethyl)sulfonyl]amino}ethyl)-5- chloro-1 H-indol-3-yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(cyanomethyl)sulfonyl]amino}ethyl)-1H-indol-3- yl]ethoxy}benzoic acid; 4-{2-[1-Benzhydryl-5-chloro-2-(2-{[(3-thienylmethyl)sulfonyl]amino}ethyl)-1H- indol-3-yl]ethoxy}benzoic acid; 4-[2-(1-Benzhydryl-5-chloro-2-{2-[2-(2-methyl-pyrrolidin-1-yl)-etHanesulfonyl amino]-ethyl}-1 H-indol-3-yl)-ethoxy]-benzoic acid; 4-[2-(1-Benzhydryl-5-chloro-2-{2-[2-(2-methyl-piperidin-1-yl)-etHanesulfonyl amino]-ethyl}-1H-indol-3-yl)-ethoxy]-benzoic acid; and 4-[2-(1-Benzhydryl-5-chloro-2-{2-[2-(2,5-dimethyl-pyrrolidin-1-yl)-etHanesulfonyl amino]-ethyl}-1 H-indol-3-yl)-ethoxy]-benzoic acid; 4-(2-{1-Benzhydryl-5-chloro-2-[2-(2-thiomorpholin-4-yl-etHanesulfonylamino)- ethyl]-1 H-indol-3-yl}-ethoxy)-benzoic acid; 4-(2-{1 -Benzhydryl-5-chloro-2-[2-(2-piperidin-1 -yl-etHanesulfonylamino)-ethyl]-1 H- indol-3-yl}-ethoxy)-benzoicacid; 4-{2-[1 -benzhydryl-5-chloro-2-(2-o-tolylsulfanylmetHanesulfonylamino- ethyl)-1 H- indol-3-yl]-ethoxy}-benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-(2-chloro-phenyIsulfanylmetHane- sulfonylamino)- ethyl]-1 H-indol-3-yl} -ethoxy)-benzoic acid; or 4-(2-{1-benzhydryl-5-chloro-2-[2-(2,6-dichloro-phenylsulfanylmetHane-sulfonyl amino)- ethyl]-1 H-indol-3-yl} -ethoxy)-benzoic acid; 4-(2-{1-benzhydryl-5-chloro-2-[2-(2,5-dimethoxy-phenylsulfanyl- metHanesulfonylamino)- ethyl]-1 H-indol-3-yl} -ethoxy)-benzoic acid; 4-[2-(1-benzhydryl-5-chloro-2-{2-[2-(3-hydroxy-pyrrolidine-1-yl)- etHanesulfonylamino]-ethyl}-1H-indol-3-yl)-ethoxy]-benzoicacid; 4-[2-(1-Benzhydryl-5-chloro-2-{2-[2-(4-hydroxy-piperidin-1-yl)- etHanesulfonylamino]-ethyl}-1H-indol-3-yl)-ethoxy]-benzoicacid; 4-(2-{1-Benzhydryl-5-chloro-2-[2-(2-pyrrolidin-1-yl-etHanesulfonylamino)-ethyl]- 1 H-indol-3-yl}-ethoxy)-benzoic acid; and 4-[2-(1-Benzhydryl-5-chloro-2-{2-[2-(2-dimethylaminomethyl-piperidin-1-yl)- etHanesulfonylamino]-ethyl}-1H-indol-3-yl)-ethoxy]-benzoicacid; 4-(2-{1 -Benzhydryl-5-chloro-2-[2-(2-imidazol-1 -yl-etHanesulfonylamino)-ethyl]-1 H- indol-3-yl}-ethoxy)-benzoic acid; 4-{3-[1 -benzhydryl-5-chloro-2-(2-{[(2,6-difluorobenzyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]propyl}benzoic acid; 4-{3-[1-benzhydryl-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H-indol-3- yl]propyl}benzoic acid; 3-[4-({2-[1 -Benzhydryl-5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]ethyl}sulfonyl)phenyl]propanoic acid; and 3-(4-{[2-(1-Benzhydryl-2-{2-[(benzylsulfonyl)amino]ethyl}-5-chloro-1H-indol-3- yl)ethyl]sulfonyl}phenyl)propanoic acid; 3-[4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2,6-difluorobenzyl)sulfonyl]amino}ethyl)- 1 H-indol-3-yl]ethyl} sulfonyl)phenyl]propanoic acid; 3-[4-({2-[1 -benzhydryl-5-chloro-2-(2-{[(2-fluorobenzyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]ethyl}suifonyl)phenyl] propanoic acid; 3-[4-({2-[1 -benzhydryl-5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl] amino}ethyl)-1 H- indol-3-yl]ethyl}sulfonyl)phenyl]propanoicacid; 4-({[(1-benzhydryl-2-{2-[(benzylsulfonyl)amino]ethyl}-5-chloro-1H-indol-3- yl)methyl]amino}methyl)benzoic acid; and 4-{[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)amino]ethyl}-5-chloro-1H-indol- 3yl)ethyl]sulfonyl}benzoic acid; 4-({2-[1 -benzhydryl-5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1 H- indol-3-yl]ethyl}sulfonyl)benzoic acid; 4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2,6-difluorobenzyl)sulfonyl] aminojethyl)-1H- indol-3-yl]ethyl}sulfonyl)benzoicacid; 4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2-fluorobenzyl)sulfonyl]amino}ethyl)-1H-indol- 3-yl]ethyl}sulfonyl)benzoic acid; and 4-(2-{1-Benzhydryl-5-chloro-2-[2-(2-pyrrolidin-1-yl-etHanesulfonylamino)-ethyl]- 1 H-indol-3-yl}-ethoxy)-benzoic acid; 4-({2-[1 -benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl] amino}ethyl)1 H- indol-3-yl]ethyl}sulfonyl)benzoicacid; 4-({2-[1-benzhydryl-5-chloro-2-(2-{[(2,6-dimethylbenzyl)sulfonyl] aminojethyl) 1H- indol-3-yl]ethyl}sulfonyl)benzoic acid; and 4-[2-(1-benzhydryl-2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1H-indol-3- yl)ethoxy]benzoic acid; and a pHarmaceutically acceptable salt form thereof. 29. A pHarmaceutical composition comprising a compound as claimed in any one of Claims 1 to 28, or a pHarmaceutically acceptable salt form thereof, and a pHarmaceutically acceptable carrier. 30. The composition as claimed in claim 29 wherein said composition is useful for the treatment of inflammation, pain, asthma or arthritic and/or rheumatic disorders in a mammal. 31. The composition as claimed in Claim 30 wherein the disorder is rheumatoid arthritis, osteoarthritis or juvenile arthritis 32. A compound of formula (A) wherein X2, n, n2 , n2 ,n3, n4, R, R2, R3 and R4 are as defined in any one of Claims 1 to 20;and R' is selected from the group consisting of -OH, -NH-S(0)2-(CH2)n2-Halo, -NH-S(O)2- CH=CH2) -NH2, or a protected form of -NH2. 33. A compound according to claim 32 Having the formula (B): wherein R is -(CH2)n-A, -(CH2)n-S-A, or -(CH2)n-O-A, where A represents: B and C are each independently selected from the group consisting of phenyl, pyridinyl, pyrimidinyl, furanyl, thiophenyl or pyrrolyl groups, each optionally substituted by from 1 to 3, preferably 1 to 2, substituents selected independently from the group consisting of H, Halogen, -CN, -CHO, -CF3, -OCF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2 , -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2, or by a 5- or 6-membered heterocyclic or heteroaromatic ring containing 1 or 2 heteroatoms selected from O, N or S; R' is selected from the group consisting of -OH, -NH-S(0)2-(CH2)n2-Halo, -NH-S(O)2- CH=CH2) -NH2, or a protected form of -NH2; R8 and R9 are independently selected from H, Halogen, -CN, -CHO, -CF3, -OCF3, -OH, - C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; R7 represents -(CH2)n4-CO2H, a C1-C8 alkyl ester of -(CH2)n4CO-H, or a pHarmaceutically acceptable acid mimic or mimetic selected from the group consisting of: wherein Ra is selected from -CF3, -CH3, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, Ci- C6 alkoxy, C1-C6 thioalkyl, -CF3, Halogen, -OH, or -COOH; Rb is selected from -CF3, - CH3, -NH2, phenyl, or benzyl, with the phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -CF3, Halogen, -OH, or -COOH; and Rc is selected from -CF3 or C1-C6 alkyl, R3 is selected from H, Halogen, -CN, -CHO, -CF3, -OCF3s -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2,-N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), or -NO2; R4 is selected from H, Halogen, -CN, -CHO, -CF3, -OCF3j -OH, -C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, -NH2, -N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), - NO2, -N-C(O)-N(C1-C63 alkyl)2, -N-C(O)-NH(C1-C63 alkyl), -N-C(O)-O-(C1-C63 alkyl), -SO2-C1-C6 alkyl, -S-C3-C6 cycloalkyl, -S-CH2-C3-C6 cycloalkyl, -SO2-C3-C6 cycloalkyl, , -SO2-CH2-C3-C6 cycloalkyl, C3-C6 cycloalkyl, -CH2-C3-C6 cycloalkyl, - O-C3-C6 cycloalkyl, , -O-CH2-C3-C6 cycloalkyl, phenyl, benzyl, benzyloxy, morpholino or other heterocycles such as pyrrolidino, piperidine, piperazine, furan, thiophene, imidazole, tetrazole, pyrazine, pyrazolone, pyrazole, imidazole, oxazole or isoxazole, the rings of each of these groups each being optionally substituted by from 1 to 3 substituents selected from the group of H, Halogen, - CN, -CHO, -CF3, -OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2, -NH(d- C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2, -SO2(C1-C63 alkyl), -SO2NH(C1-C63 alkyl), - SO2N(C1-C63 alkyl)2, or OCF3; n is an integer from 0 to 3; ni is an integer from 0 to 3; n2 is an integer from 0 to 3 n3 is an integer from 0 to 3; n4 is an integer from 0 to 2; and, X is a linking group selected from the group consisting of of -O-, -CH2-, -SO2-, -NH-, and -N(C1-C6-alkyl)-. 34. A compound according to claim 32 Having the formula (C): wherein: R3, R4, R', R7.9, X, n,, n2and n4 are as defined in claim 32 and R10, R11, R12, R13, R14 and R15 are each independently selected from the group consisting of H, Halogen, -CN, -CHO, -CF3, -OCF3, -OH, -C1-C6 alky!, C1-C6 alkoxy, -NH2, - N(C1-C6 alkyl)2, -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2) or a 5- or 6- membered heterocyclic or heteroaromatic ring containing 1 or 2 heteroatoms selected from O, N or S. 35. A compound according to any one of claims 32 to 34 wherein the Halogen atom in the R1 group -NH-S(O)2-(CH2)n2-Halo is bromine or chlorine. 36. A compound according to claim 31 Having the formula (D): wherein X, n4, R3, R4 and R8-is are as defined in Claim 32. 37. A compound according to claim 32 Having the formula (E): wherein X, R3 and R4 are as defined in Claim 33 and R10-R15 are each independently selected from H, Halogen, -CN, -CHO, -CF3, -OCF3, - OH, -C1-C6 alkyl, C1-C6 alkoxy, -NH2, -N(C1-C6 alkyl)2) -NH(C1-C6 alkyl), -N-C(O)-(C1-C6 alkyl), -NO2, or a 5- or 6-membered heterocyclic or heteroaromatic ring containing 1 or 2 heteroatoms selected from O, N and S. 38. A compound according to any one of claims 34 to 37 wherein R10-R15 are each H. 39. A compound according to Claim 32 which is one of the following: 4-{2-[2-(2-Amino-ethyl)-1-benzyhydryl-5-chloro-1H-indol-3-yl]-etHanesulfonyl}-benzoic acid methyl ester; 4-{2-[2-(2-Amino-ethyl)-1 -benzyhydryl-5-chloro-1 H-indol-3-yl]-ethoxy}-benzoic acid methyl ester; and 4-{3-[2-(2-Amino-ethyl)-1 -benzyhydryl-5-chloro-1 H-indol-3-yl]-propyl}-benzoic acid methyl ester. 4-{2-[2-(2-Amino-ethyl)-1 -benzhydryl-5-chloro-1 H-indol-3-yl]-ethylamino}-benzoic acid methyl ester 4-({2-[2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethyl}-methyl-amino)- benzoic acid methyl ester 40. A process for the preparation of a compound as defined in Claim 1 which comprises one of the following: a) reacting a compound of formula A wherein X2, n, rii , n2 ,n3, n4, R, R2, R3 and R4 are as defined in Claim 1; and R' is NH2, with a sulfonyl Halide of formula Hal-SO2(CH2)n2X1R1) wherein Hal is a suitable Halogen and n2l X,, and Ri are as defined in Claim 1, to give a corresponding compound of formula (I), or b) hydrolyzing a compound of formula I wherein R2 comprises an ester to provide the corresponding acid, or c) converting a compound of formula I Having a reactive substituted to a different compound of formula I, or d) reacting a compound of formula A wherein X2, n, ni , n2 ,n3, n4, R, R2, R3 and R4 are as defined in Claim 1; and R' is -NH-S(O)2-(CH2)n2-Hal0 or -NH-S(O)2-CH=CH2 and n2 is as defined in Claim 1, with a nucleophile of formula: HX1R1- wherein Xi and Ri are as defined in Claim 1, to give a corresponding compound of formula (I); or e) alkylating a compound of formula wherein R, Ri, R3, R4, Xi and n2 are as defined in Claim 1, with an aldehyde or acetal of formula wherein R2, X2 and n3 are as defined in Claim 1, or f) reacting a 3-formyl indole of formula wherein PRT is a protecting group, R, R1, R3, R4, X1 and n2 are as defined in Claim 1, with an amine of formula: RiiiHN-CH2-R2 whe*ein Ftm is hydrogen or CrC3 alkyl and R2 is as defined in Claim 1, to give a compound of formula I wherein X2 is -RjjjN-CH2-, or g) reacting an alkyl amine of formula wherein hal is a suitable halogen and R, R3, and R4 are as defined in Claim 1, with an alkyne of formula wherein R1, R2, X1( and X2 are as defined in Claim 1 to give a compound of formula (I), or h) reacting a halide of formula wherein halo is a suitable halogen and R, R2l R3l R4, X2, ni and n3 are as defined in Claim 1,with a sulfonamide of formula wherein R1, X1 and n2 are as defined in Claim 1 to give a corresponding compound of formula (I). The invention discloses a compound of the formula (I): wherein R, R1, R2, R3, R4, X1, X2, n1 and n2 are as defined in the specification an effective inhibitor of cytosolic phospholipase A2 and process for its preparation.

Documents:

698-KOLNP-2004-(02-07-2012)-CORRESPONDENCE.pdf

698-KOLNP-2004-(02-07-2012)-PA.pdf

698-KOLNP-2004-CORRESPONDENCE.pdf

698-KOLNP-2004-FOR ALTERATION OF ENTRY IN THE PATENT REGISTER.pdf

698-KOLNP-2004-FORM-27.pdf

698-kolnp-2004-granted-abstract.pdf

698-kolnp-2004-granted-assignment.pdf

698-kolnp-2004-granted-claims.pdf

698-kolnp-2004-granted-description (complete).pdf

698-kolnp-2004-granted-examination report.pdf

698-kolnp-2004-granted-form 1.pdf

698-kolnp-2004-granted-form 18.pdf

698-kolnp-2004-granted-form 2.pdf

698-kolnp-2004-granted-form 3.pdf

698-kolnp-2004-granted-form 5.pdf

698-kolnp-2004-granted-gpa.pdf

698-kolnp-2004-granted-reply to examination report.pdf

698-kolnp-2004-granted-specification.pdf

698-KOLNP-2004-PA.pdf