Title of Invention


Abstract Fungicidal composition for agricultural use comprising fthalide and prochloraz in a weight ratio in the range 1:4 to 4:1.
Full Text The invention relates to a fungicidal composition for agricultural use.
1 -{N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl] having the common name prochloraz and 4,5,6,7-tetrachlorophthalide having the common name fthalide have been already used individually as fungicides for agricultural purpose.
Fthalide has been used for controlling blast diseases of rice, having an excellent preventive effect with a high safety for mammals as well as fish and shellfish. However, its use is limited to that of a preventive fungicide. It is ineffective for example in treating rice plants, once they have become infected by Pyricularia oryzae.
On the other hand, prochloraz has been used as a rice seed disinfectant but has not yet been employed for direct application to rice plant.
Surprisingly, it has been now found that the compound shows outstanding preventive and curative effects to the blast disease of rice, by directly applying it to rice plants both in greenhouses and in the field.
We have now surprisingly found that fthalide shows a marked synergistic action by using it in combination with prochloraz.
The fungicidal compositions of the invention demonstrate extremely good control of, in particular, Pyricularia oryzae, displaying a synergistic action that would not be expected from the properties of the individual components. The composition shows not only a preventive effect but also an excellent curative effect, resulting in a reduction in the requisite amounts of both chemicals compared with using one component alone. The fungicidal compositions for agricultural use according to the present invention are also effective inter alia in controlling spot diseases of rice (such as brown spot) and Fusarium diseases.
The ratio of prochloraz to fthalide can vary considerably but is generally in the range 4:1 to 1:4 by weight, preferably 2:1 to 1:2 and especially 1.3:1 to 1:1.6.

The fungicidal compositions for agricultural use according to the invention can be provided in a variety of formulation types, such as a dust, granule, dust-granule mixture, wettable powder, suspension concentrate, emulsifiable concentrate (EC) , flowable and the like, in accordance with known methods for preparing such formulations. As auxiliary substances for preparing these formulations, there can be mentioned, for example, solid carriers such as kieselguhr, slaked lime, calcium carbonate, talc, white carbon, kaolin, bentonite and zeolite; solvents such as toluene, xylene, naphtha, ethanol, dioxane, acetone, isophorone, methyl isobutyl ketone, dimethylformamide, dimethyl sulfoxide and N-methyl-2-pyrrolidone; wetting agents such as sodium alkylsulfate, sodium alkylbenzenesulfonate, sodium lignin sulfonate, polyoxyethyleneglycol alkyl ether, polyoxyethylene lauryl ether, polyoxyethylene alkylaryl ether, polyoxyethylene sorbitan fatty acid ester as well various other surface active agents used in the art.
Fungicidal compositions for agricultural use according to the invention show a high safety toward mammals and fish and demonstrate little or no phytotoxicity to useful crops, especially rice.
The fungicidal compositions for agricultural use can be used in combination with other fungicides as well as insecticides, herbicides and plant growth regulating agents.
Fungicide formulations for agricultural use according to the invention comprise in general as total amount of both active compounds 1.0 to 95.0%, preferably 3.0 to 70% of active compounds. The application dosage of the formulation usually amounts from 1 50 to 600 g, preferably 250 to 400 g of the combined active compounds per hectare.
The following examples serve to illustrate the preparation of the fungicidal compositions for agricultural use of this invention.
Formulation 1 (driftless dust)
A dust is obtained by uniformly mixing 1.5 parts by weight of prochloraz, 1.5 parts by weight of fthalide, 1.0 part by weight of white carbon, 0.5 part by weight of an aggregating agent and 95.5 parts by weight of clay.

Formulation 2 (wettable powder)
A wettable powder is obtained by mixing uniformly 1 5.0 parts by weight of prochloraz, 15.0 parts by weight of fthalide, 5.0 parts by weight of sodium lignin sulfonate, 1 5.0 parts by weight of white carbon and 50.0 parts by weight of kaolin.
Formulation 3 (granule)
A granule is obtained by mixing uniformly 1.5 parts by weight of prochloraz, 1.5 parts by weight of fthalide, 30.0 parts by weight of bentonite and 67.0 parts by weight of clay according to conventional methods.
The fungicidal actions of the composition of the present invention against Pyricularia oryzae (rice blast) are demonstrated in the following experimental examples.
Example 1 Control of Pvricularia orvzae
Rice plants (variety "Nihonbare") in the 3-4-leaf stage, which had been grown in the soil culture in plastic pots 9 cm in diameter, were used in tests to show both preventive effects test and curative effects.
The active ingredients were used as their commercially available formulations; fthalide as a 20% wettable powder and prochloraz as a 25% EC, which were diluted to the predetermined concentrations. The diluted formulations were sprayed onto the plants in an amount of 30 ml for every 3 pots.
Plants were inoculated by spraying with a spore suspension (5-6 x I08/ml) of Pyricularia oryzae, which had been obtained from rice plants previously infected by blast disease.
In the preventive test, the plants were inoculated one day after the application of the test substances and then placed for 24 hours in a humid room at 25±2°C and then left in a greenhouse to await the effects of the disease.

n the curative test, the test substances were applied 24 hours after the inoculation with the fungus. The plants were then left in a greenhouse to await effects of the disease.
The degree of infection was determined by evaluating the damage to the plants 7 days after the inoculation, from which a protective value could be calculated according to the following formula:
Degree of damage Degree of damage
in untreated plots — in treated plots
Protective value = Results of the (Table REMOVED)7
Rice seeds (variety "Nihonbare") were sown in drills in a non-flooded rice nursery. In order to expedite and make the outbreak of disease uniform, leaves, infested with Pyricularia oryzae, and cut into pieces about 1 cm in length, were scattered throughout the test field as a source of inoculation. As a result, rice plants in the test field were placed under the state of being infected with blast disease.
The formulations to be tested were prepared according to the procedure of Example 1 and were applied at a predetermined concentration by spraying twice with a small-size sprayer at a rate of 100 ml per plot.
The first spray was carried out at the 3-4 leaf stage whereby a lesion appeared on 2-leaf or 3-leaf and the second spray took place 7 days later.
Inspections of the outbreak of the disease were carried out 3 times, that is to say, 7 days after the first spray and immediately before the second spray (first time), 2 days after the second spraying (second time) and 8 days after the second spraying (third time), to evaluate the controlling effect of the formulations.
The degree of damage, expressed in %, due to rice blast was evaluated in the respective treated plots and the protective value (%) of respective formulation were calculated according to the

We claim;
1. Fungicidal composition for agricultural use comprising fthalide and
prochloraz in a weight ratio in the range 1:4 to 4:1.
2. Fungicidal composition as claimed in claim 1 wherein the weight ratio is
in the range 1:2 to 2:1.
3. Fungicidal composition as claimed in claims 1 or 2 wherein the weight
ratio is in the range 1:1.3 to 1.6:1.
4. Fungicidal composition as claimed in claims '1 to 3 further comprising
solid carriers, solvents, wetting agents or various other surface active











1669-DEL-1996-Description (Complete)-(10-12-2007).pdf

1669-del-1996-description (complete).pdf

















Patent Number 220757
Indian Patent Application Number 1669/DEL/1996
PG Journal Number 30/2008
Publication Date 25-Jul-2008
Grant Date 04-Jun-2008
Date of Filing 26-Jul-1996
Name of Patentee AGREVO UK LIMITED
Applicant Address
# Inventor's Name Inventor's Address
PCT International Classification Number A01N 33/06
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 19368/95 1995-07-28 Japan