| Title of Invention | A METHOD FOR SYNTHESIZING CONJUGATES OF ONE OR MORE SYNTHET8C WATER SOLUBLE POLYMERS WITH A CHEMOKINE , A GROWTH FACTOR OR A POLYPEPTIDE HORMONE, OR AN ANTAGONIST THEREOPF THAT PRESERVES MOR E OF TRHWE IN VITRO RECEPTOR BIN DING POTENCY |
|---|---|
| Abstract | Methods are providied for the systhesis of polymer conjugates of cylokines, chemokines, growth factors, polypeptide hormones and receptor-binding antagonists thereof, which conjugates retain unusually high receptor-binding activity. Preparation of polymer conjugates according to the methods of the present invention diminishes or avoids steric inhibition of receptor ligand interections that commonly results from the attachment of poplymer to receptor-binding regions of cytokynes, chemokines, growth factors and polypeptide hormones, as well as to egonistic and attagonistic analogs thereof. The invention also provides conjugates and compositions produced by such methods. The conjugtes of the present invention retain a higher level of receptor-binding activity than those produced by traditional polymer coupling methods that are not targeted to avoid receptor-binding domains of cytokines, chemkines, growth factors and polypeptide hormones. The conjugates of the present invention also exhibit an extended half-life in vivo and viro compared to conjugated cytokines, chemokines, growth factors and polypeptide hormones. The present invention also provides kits comprising such conjugates and/or compositions, and methods of use such conjugates and compositions in a variety of diagnostic, prophylactic, therapeutic and bloprocessing applications. |
| Full Text |
|---|
01337-kolnp-2005-description complete.pdf
01337-kolnp-2005-international publication.pdf
1337-kolnp-2005-granted-abstract.pdf
1337-kolnp-2005-granted-assignment.pdf
1337-kolnp-2005-granted-claims.pdf
1337-kolnp-2005-granted-correspondence.pdf
1337-kolnp-2005-granted-description (complete).pdf
1337-kolnp-2005-granted-drawings.pdf
1337-kolnp-2005-granted-form 13.pdf
1337-kolnp-2005-granted-form 18.pdf
1337-kolnp-2005-granted-form 3.pdf
1337-kolnp-2005-granted-form 5.pdf
1337-kolnp-2005-granted-gpa.pdf
1337-kolnp-2005-granted-letter patent.pdf
1337-kolnp-2005-granted-reply to examination report.pdf
1337-kolnp-2005-granted-sequence listing.pdf
1337-kolnp-2005-granted-specification.pdf
| Patent Number | 219922 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indian Patent Application Number | 01337/KOLNP/2005 | |||||||||||||||
| PG Journal Number | 20/2008 | |||||||||||||||
| Publication Date | 16-May-2008 | |||||||||||||||
| Grant Date | 14-May-2008 | |||||||||||||||
| Date of Filing | 11-Jul-2005 | |||||||||||||||
| Name of Patentee | MOUNTAIN VIEW PHARMACETICALS INC. | |||||||||||||||
| Applicant Address | 3475-S, EDISON WAY, MENLO PARK, CA 94025, U.S.A. | |||||||||||||||
Inventors:
|
||||||||||||||||
| PCT International Classification Number | A61K | |||||||||||||||
| PCT International Application Number | PCT/US2003/041162 | |||||||||||||||
| PCT International Filing date | 2003-12-23 | |||||||||||||||
PCT Conventions:
|
||||||||||||||||