Title of Invention

BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

Abstract TITLE:BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS. This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I. The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections. (FIG.NIL)
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Documents:

740-kolnp-2003-granted-abstract.pdf

740-kolnp-2003-granted-assignment.pdf

740-kolnp-2003-granted-claims.pdf

740-kolnp-2003-granted-correspondence.pdf

740-kolnp-2003-granted-description (complete).pdf

740-kolnp-2003-granted-examination report.pdf

740-kolnp-2003-granted-form 1.pdf

740-kolnp-2003-granted-form 13.pdf

740-kolnp-2003-granted-form 18.pdf

740-kolnp-2003-granted-form 3.pdf

740-kolnp-2003-granted-form 5.pdf

740-kolnp-2003-granted-gpa.pdf

740-kolnp-2003-granted-letter patent.pdf

740-kolnp-2003-granted-reply to examination report.pdf

740-kolnp-2003-granted-specification.pdf


Patent Number 219366
Indian Patent Application Number 740/KOLNP/2003
PG Journal Number 18/2008
Publication Date 02-May-2008
Grant Date 30-Apr-2008
Date of Filing 09-Jun-2003
Name of Patentee NEUROGEN CORPORATION ; and
Applicant Address 35 NORTHEAST INDUSTRIAL ROAD, BRANFORD, CT 06405, UNITED STATES OF AMERICA.
Inventors:
# Inventor's Name Inventor's Address
1 LI GUIYING #8 VALLEY COURT, BRANDFORD, CT 06405, U.S.A.
2 PETERSON JOHN M 28 HIGHLAND TERRACE, MADISON, CT 06443, U.S.A.
3 ALBAUGH PAMELA 10475 TREBAH CIRCLE, CARMEL, IN 46032, U.S.A.
4 CURRIE KEVIN S 33 CLEAR LAKE MANOR ROAD, NORTH BRANDFORD, CT 06471, U.S.A.
5 CAI GUOLIN 2382 WHITECHAPEL PLACE, THOUSAND OAKS, CA 91362, USA.
6 MAYNARD GEORGE D 27 GLENWOOD ROAD, CLINTON, CT 06413, U.S.A.
7 LING HONG XIE 136 RENEE'S WAY, GUILFORD, CT 06437, U.S.A
8 LUKE GEORGE P 17 VIENNA LANE, CLINTON, CT 06413, U.S.A.
9 ALLEN MARTIN PATRICK 63 MYSTIC ROAD, NORTH STONINGTON, CT 06359, U.S.A
10 LIRAS SPIROS 12 KIDDS WAY, STONINGTON, CT 06378, U.S.A
11 GUSTAVSON LINDA M 3 CHESTNUT COURT, GUILFORD, CT 06437, U.S.A.
12 LEE KYUNGAE 6 FINCH LANE, GUILFORD, CT 06437, U.S.A
13 SINGH VINOD 4056 IIT CAMPUS, KANPUR 208 016, INDIA.
14 YUAN JUN 40 SPRUCE HILL DRIVE, GUILFORD, CT 06437, U.S.A.
15 GHOSH MANUKA 211 E. MAIN STREET #83, BRANFORD, CT 06405, USA.
16 LIU NIAN 20 COUNTRY ROAD, NORTH BRANFORD, CT 06471, U.S.A.
17 MITCHELL SCOTT 13 MORRIS ROAD, EAST HAVEN,CT 06513, U.S.A.
18 HUTCHINSON ALAN 29 KIMBERLEY LANE, MADISON, CT 06443, U.S.A.
PCT International Classification Number C07D 401/14
PCT International Application Number PCT/US01/50038
PCT International Filing date 2001-12-21
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 60/257,492 2000-12-21 U.S.A.