Title of Invention	ACTIVE CATALYSTS FOR STEREOSELECTIVE RING-OPENING REACTIONS
Abstract	A method for making a chiral transition metal-ligand catalyst complex that is active in catalyzing stereoselective ring opening reactions includes contacting an asymmetric tetradentate ligand, in an excess of a Bronsted acid, with a salt of a first row transition metal, wherein the acidity of the conjugate acid of the salt is the same as or less than the acidity of the Bronsted acid, under conditions effective to allow formation of the active chiral transition metal-ligand catalyst complex, and forming a solution of the complex in a water-miscible, protic solvent from which the active complex can be precipitated by the addition of water and adding water to the solution to precipitate at least a portion of the complex.

Title of Invention

ACTIVE CATALYSTS FOR STEREOSELECTIVE RING-OPENING REACTIONS

Abstract

A method for making a chiral transition metal-ligand catalyst complex that is active in catalyzing stereoselective ring opening reactions includes contacting an asymmetric tetradentate ligand, in an excess of a Bronsted acid, with a salt of a first row transition metal, wherein the acidity of the conjugate acid of the salt is the same as or less than the acidity of the Bronsted acid, under conditions effective to allow formation of the active chiral transition metal-ligand catalyst complex, and forming a solution of the complex in a water-miscible, protic solvent from which the active complex can be precipitated by the addition of water and adding water to the solution to precipitate at least a portion of the complex.

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Patent Number

215376

Indian Patent Application Number

386/CHENP/2005

PG Journal Number

13/2008

Publication Date

31-Mar-2008

Grant Date

26-Feb-2008

Date of Filing

14-Mar-2005

Name of Patentee

RHODIA PHARMA SOLUTIONS INC

Applicant Address

259 Prospect Plains Road, Cranbury, New Jersey 08512,

Inventors:

#	Inventor's Name	Inventor's Address
1	LARROW, Jay, F	5 Edmunds Place, Wakefield, MA 01880,
2	HEMBERGER, Karl	4 Essex Reach, Essex, MA 01929,
3	KABIR, Hocine	20 allee du Bois Rond, F-69360 Serezin du Rhone,
4	MOREL, Philippe	7 L'Orée du Village, F-38200 Chuzelles,

PCT International Classification Number

B01J 31/18

PCT International Application Number

PCT/US03/25680

PCT International Filing date

2003-08-18

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	10/245,110	2002-09-17	U.S.A.