Indian Patents. 214918:ORAL CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION

Title of Invention	ORAL CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION
Abstract	An oral controlled release pharmaceutical composition comprising metaxalone, a pharmaceutical acceptable release rate controlling excipient, and pharmaceutical^ acceptable excipients, wherein the oral controlled release pharmaceutical composition provides peak plasma levels at a time of about 3 hours or more after oral administration of the composition.

Full Text	Form 2 THE PATENTS ACT, 1970 COMPLETE SPECIFICATION (See Section 10) A process for the preparation of oil to get colored flames in oil lamps Dr. Omprakash ShrisivasYemul 340; Sakhar Peth, Solapur 413 005 Maharashtra. As Indian National The following specitication particularly describes fee nature of this invention and the manner in which it is to be performed: Original 838/MUM/2002 24/9/02 The process for preparation of oil which will produce colored flames in oil lamps is described made as per fee process of this invention is useful for decorative and aroma, color therapy purpose. The oil as prepared by this specification wherein, the flame of the oil lamp is single colored. In particular this invention relates to the process for preparation of oil to get colored flame in oil lamps useful for decorative and therapeutic purpose. Oil lamps were used in ancient times as a source of light and more recently as a decorative light source, in addition to its conventional properties the color of the flame of oil lamp has been intentionally changed for decorative and for color therapy purpose. Recently the commercial significance of oil lamp has been shifted from a basically utilitarian product that merely provides illumination to a product whose function is to create a desired atmosphere by means of light color and odor. In the conventional oil lamps used they emit yellow color only. The earlier-reported literature shows that German patents DE 2222939, and 19516244, Chinese patent CN 110875 Poland patent PL 155828 have described the process for making the colored flame oil lamps. However, in all me above process there is major draw back is that the flame color isn't .uniform in one color instead it shows partial yellow color to flame. This partial coloring of flame is due to dominance of yellow color in flame. In order to combat this one needs the burning material, which will produce colorless flame, which is achieved by using the oxygen rich materials. In German patents DE 19961548 and 19961547 used the steel wire or graphite coated with metal salts and chloro alkanes to enhance the color of flame. However, it still doesn't produce uniform single bright colored flame. Steel wire and coating with metal salts adds the total material cost very high, and the resulting lamp doesn't last longer time. The oil prepared by the process of this invention namely colored flame oil lamps are reportedly developed first time by the inventors of the present invention and hence there are no earlier methods known for the preparation of such type of oils which will produce colored flames oil lamps. The main object of the present invention is therefore to provide a process for the preparation of oil to get colored flames in oil lamps useful for the decorative and therapy purpose. Another objective of the invention is to provide a process for the preparation of oil for colored flame in oil lamps that overcomes the deficiencies of the conventionally used oil lamps for decorative and therapy purposes. It is non-toxic free of pollutants. Accordingly, the present invention provides a process for the preparation of oil to get colored flames in oil lamp whereas, the oil of the lamp is made from metal salts, fatty compounds, hydroxy compounds, coloring agents, fragrance and wick made of pure cotton or glass fibers. In another embodiment of the invention, metal salts used may be borax, copper sulfate, copper chloride, lithium chloride, lithium bromide, strontium chloride, strontium nitrate, magnesium sulfate, strontium carbonate, boric acid, calcium chloride, sodium chloride, potassium sulfate, potassium nitrate, calcium carbonate or combination of these materials. In another embodiment of the invention, fatty compounds used in oil material may be stearic acid, stearyl alcohol, elainic acid, palmitic acid, lauric acid, caprylic acid, amyl alcohol or combination of these materials. „water soluble In another embodiment of the invention, the main burnable material (hydroxyl compound) used may be glycerol,.inositol, giyoxal, ethylene glycol, oxalic acid, suecanic acid, ascorbic acid, maleic acid, malonie acid, mannitoi, lactic acid, lactose, acetic acid, acetoacetic acid, acetoxyacetic acid, tartaric acid, sorbitol, pyruvic acid, trioxaae, methanol, xylose, xytitol, galactose or combination of these materials. In another embodiment of the invention, coloring agents used in oil material may be edible food grade colors like red, yellow, green, blue, orange, violet, and white or combination of these materials. In another embodiment of the invention, fragrance used in oil material may be fragrance such as rose, sandal, lavender or combination of these materials. The process of the present invention is described with reference to following examples, which are illustrative only and should not be construed to limit the scops of this invention in any manner. Example 1 In a 75 ml conical flask I gnis of copper chloride was dissolved in 3 ml of water, 2 gms of stearic acid was mixed to above solution. The whole mixture was heated up to 70 °C for 3 mins. to make solution homogenous. 30 ml sorbitol was added with agitation. Green edible dye and rose fragrance was mixed to above solution. This 23 oil of resultant oil was poured in glass lamp with cotton wick The resulting oil lamp will produce green colored flame with rose odor. Example 2 In a 73 ml conical flask 1.2 gms of strontium chloride was dissolved in 4.5 ml of water, 3 ml of elainic acid Was mixed to above solution. The whole mixture was heated up to 60 °C for 8 sains, to make solution homogenous. 45 ml glycerin was added with agitation. Red edible dye and sandal fragrance was mixed to above solution. This 30 ml of resultant oil was poured in glass lamp with cotton wick. The resulting oil lamp will produce red colored flame with sandal odor. Example 3 In a 75 ml conical flask 0.S gms of sodium chloride was dissolved in 2 ml of water, 2 gms of pelmatic acid was mixed to above solution. The whole mixture was heated up to 50 °C tor 13 mins. to make solution homogenous. 40 ml ethylene glycol was added with agitation. Yellow edible dye and lavender fragrance was mixed to above solution. This 20 ml of resultant oil was poured in glass lamp with cotton wick. the resulting oil tamp will produce yellow colored flame with lavender odor. Esample 4 In a 73 ml conical flask 2 gms of calcium chloride was dissolved in 6 ml of water, 1.5 gms of laurie acid was mixed to above solution. The whole mixture was heated up to SO °C tor 3 mins. to make solution homogenous. 65 ml glyoxal was added with agitation. Orange edible dye and rose fragrance was mixed to above solution. This 50 ml of resultant oil was poured in glass lamp with cotton wick. The resulting oil lamp will produce orange colored flame with rose odor. Example 5 In a 73 ml conical flask 1.8 gms of magnesium sulfate was dissolved in 5.5 ml of water, 1.8 gms of caprync acid was mixed to above solution. The whole mixture was heated up to 75 °C for 8 mins. to make solution homogenous: 50 ml xylose was added with agitation white edible dye and sandal fragrance was mixed to above solution. This 30 ml of resultant oil was poured in glass lamp with cotton wick. The resulting oil lamp will' produce white colored fiame with sandal odor. Example 6 In a 73 ml conical flask 1.5 gms of potassium nitrate was dissolved in 2.5 ml of water, 1.2 gms of steryi alcohol was mixed to above solution. The whole mixture was heated up to 50 °C for 10 mins. to make solution homogenous. 55 ml mannitol was added with agitation. Violet edible dye and lavender fragrance was mixed to above solution. This 10 ml of resultant oil was poured in glass lamp with cotton wick The resulting oil lamp will produce violet colored Same with lavender odor. Advantages of the present inveadan 1. The oil prepared by this method can be used in any lamps with out modifications and its burning time is longer. 2. The flame produced by this method doesn't show any yellow color. The fiame shows blight single colored name. 3. The process of this invention is amenable for scale up operation. I Claims 1 A process for the preparation of oil to get colored flames in oil lamps, comprises the following steps (a) dissolving the metal salts in water, (b) mixing fatty compounds to solution of step (a), (c) heating the mixture of step (b) to make it homogenous, (d) adding water soluble burnable agent to the homogenous content of (c) followed by mixing coloring agents, and fragrance. 2. A process as claimed in claim 1 wherein the metal salts used may be borax, copper sulfate, copper chloride, lithium chloride, lithium bromide, strontium chloride, strontium nitrate, magnesium sulfate, boric acid, calcium chloride, potassium sulfate, potassium nitrate, or combination of these materials. 3. A process as claimed in claims 1 and 2, wherein the fatty compound used may¬be steric acid, steryl alcohol, elainic acid, palmitic acid, lauric acid, caprylic acid, amyl alcohol or combination of these materials. 4. A process as claimed in claims 1 to 3, wherein the water soluble burning agent is prepared from hydroxyl compounds used may be glycerol, inasiiol, glyoxal, ethylene glycol, oxalic acid, succinic acid, ascorbic acid, maleic acid, mannitol, lactic acid, acetic acid, tartaric acid, sorbitol, trioxane, methanol, xylose or combination of these materials. 5. A process as claimed in claims 1 to 4, wherein the coloring agent used may be edible food grade water soluble dyes like red, yellow, green, blue, orange, violet or combination of these materials. 6. A process as daisied in claims 1 to 5, wherein the fragrance used may be fragrances such as rose, sandal, lavender, or combination of these materials. Dr. Omprskash Shrinivas Yemul Dated this 24th day of Sep 2002

Full Text

Form 2
THE PATENTS ACT, 1970
COMPLETE SPECIFICATION
(See Section 10)
A process for the preparation of oil to get colored flames in oil lamps
Dr. Omprakash ShrisivasYemul
340; Sakhar Peth, Solapur 413 005 Maharashtra.
As Indian National
The following specitication particularly describes fee nature of this invention and the manner in which it is to be performed:
Original
838/MUM/2002
24/9/02

The process for preparation of oil which will produce colored flames in oil lamps is described made as per fee process of this invention is useful for decorative and aroma, color therapy purpose. The oil as prepared by this specification wherein, the flame of the oil lamp is single colored. In particular this invention relates to the process for preparation of oil to get colored flame in oil lamps useful for decorative and therapeutic purpose.
Oil lamps were used in ancient times as a source of light and more recently as a decorative light source, in addition to its conventional properties the color of the flame of oil lamp has been intentionally changed for decorative and for color therapy purpose. Recently the commercial significance of oil lamp has been shifted from a basically utilitarian product that merely provides illumination to a product whose function is to create a desired atmosphere by means of light color and odor.
In the conventional oil lamps used they emit yellow color only. The earlier-reported literature shows that German patents DE 2222939, and 19516244, Chinese patent CN 110875 Poland patent PL 155828 have described the process for making the colored flame oil lamps. However, in all me above process there is major draw back is that the flame color isn't .uniform in one color instead it shows partial yellow color to flame. This partial coloring of flame is due to dominance of yellow color in flame. In order to combat this one needs the burning material, which will produce colorless flame, which is achieved by using the oxygen rich materials. In German patents DE 19961548 and 19961547 used the steel wire or graphite coated with metal salts and chloro alkanes to enhance the color of flame. However, it still doesn't produce uniform single bright colored flame. Steel wire and coating with metal salts adds the total material cost very high, and the resulting lamp doesn't last longer time.
The oil prepared by the process of this invention namely colored flame oil lamps are reportedly developed first time by the inventors of the present invention and hence there are no earlier methods known for the preparation of such type of oils which will produce colored flames oil lamps.
The main object of the present invention is therefore to provide a process for the preparation of oil to get colored flames in oil lamps useful for the decorative and therapy purpose. Another objective of the invention is to provide a process for the preparation

of oil for colored flame in oil lamps that overcomes the deficiencies of the conventionally used oil lamps for decorative and therapy purposes. It is non-toxic free of pollutants.
Accordingly, the present invention provides a process for the preparation of oil to get colored flames in oil lamp whereas, the oil of the lamp is made from metal salts, fatty compounds, hydroxy compounds, coloring agents, fragrance and wick made of pure cotton or glass fibers.
In another embodiment of the invention, metal salts used may be borax, copper
sulfate, copper chloride, lithium chloride, lithium bromide, strontium chloride, strontium nitrate,
magnesium sulfate, strontium carbonate, boric acid, calcium chloride, sodium chloride,
potassium sulfate, potassium nitrate, calcium
carbonate or combination of these materials.
In another embodiment of the invention, fatty compounds used in oil material
may be stearic acid, stearyl alcohol, elainic acid, palmitic acid, lauric acid, caprylic
acid, amyl alcohol or combination of these materials.
„water soluble
In another embodiment of the invention, the main burnable material (hydroxyl compound) used may be glycerol,.inositol, giyoxal, ethylene glycol, oxalic acid, suecanic acid, ascorbic acid, maleic acid, malonie acid, mannitoi, lactic acid, lactose, acetic acid, acetoacetic acid, acetoxyacetic acid, tartaric acid, sorbitol, pyruvic acid, trioxaae, methanol, xylose, xytitol, galactose or combination of these materials.
In another embodiment of the invention, coloring agents used in oil material may be edible food grade colors like red, yellow, green, blue, orange, violet, and white or combination of these materials.
In another embodiment of the invention, fragrance used in oil material may be
fragrance such as rose, sandal,
lavender or combination of these materials.
The process of the present invention is described with reference to following
examples, which are illustrative only and should not be construed to limit the scops of
this invention in any manner.
Example 1
In a 75 ml conical flask I gnis of copper chloride was dissolved in 3 ml of water, 2 gms of stearic acid was mixed to above solution. The whole mixture was heated up to 70 °C for 3 mins. to make solution homogenous. 30 ml sorbitol was

added with agitation. Green edible dye and rose fragrance was mixed to above solution. This 23 oil of resultant oil was poured in glass lamp with cotton wick The resulting oil lamp will produce green colored flame with rose odor.
Example 2 In a 73 ml conical flask 1.2 gms of strontium chloride was dissolved in 4.5 ml of water, 3 ml of elainic acid Was mixed to above solution. The whole mixture was heated up to 60 °C for 8 sains, to make solution homogenous. 45 ml glycerin was added with agitation. Red edible dye and sandal fragrance was mixed to above solution. This 30 ml of resultant oil was poured in glass lamp with cotton wick. The resulting oil lamp will produce red colored flame with sandal odor.
Example 3
In a 75 ml conical flask 0.S gms of sodium chloride was dissolved in 2 ml of water, 2 gms of pelmatic acid was mixed to above solution. The whole mixture was heated up to 50 °C tor 13 mins. to make solution homogenous. 40 ml ethylene glycol was added with agitation. Yellow edible dye and lavender fragrance was mixed to above solution. This 20 ml of resultant oil was poured in glass lamp with cotton wick. the resulting oil tamp will produce yellow colored flame with lavender odor.
Esample 4
In a 73 ml conical flask 2 gms of calcium chloride was dissolved in 6 ml of water, 1.5 gms of laurie acid was mixed to above solution. The whole mixture was heated up to SO °C tor 3 mins. to make solution homogenous. 65 ml glyoxal was added with agitation. Orange edible dye and rose fragrance was mixed to above solution. This 50 ml of resultant oil was poured in glass lamp with cotton wick. The resulting oil lamp will produce orange colored flame with rose odor.
Example 5
In a 73 ml conical flask 1.8 gms of magnesium sulfate was dissolved in 5.5
ml of water, 1.8 gms of caprync acid was mixed to above solution. The whole
mixture was heated up to 75 °C for 8 mins. to make solution homogenous: 50 ml
xylose was added with agitation white edible dye and sandal fragrance was mixed to

above solution. This 30 ml of resultant oil was poured in glass lamp with cotton wick. The resulting oil lamp will' produce white colored fiame with sandal odor.
Example 6
In a 73 ml conical flask 1.5 gms of potassium nitrate was dissolved in 2.5 ml of water, 1.2 gms of steryi alcohol was mixed to above solution. The whole mixture was heated up to 50 °C for 10 mins. to make solution homogenous. 55 ml mannitol was added with agitation. Violet edible dye and lavender fragrance was mixed to above solution. This 10 ml of resultant oil was poured in glass lamp with cotton wick The resulting oil lamp will produce violet colored Same with lavender odor.
Advantages of the present inveadan
1. The oil prepared by this method can be used in any lamps with out
modifications and its burning time is longer.
2. The flame produced by this method doesn't show any yellow color. The fiame
shows blight single colored name.
3. The process of this invention is amenable for scale up operation.

I Claims
1 A process for the preparation of oil to get colored flames in oil lamps, comprises the following steps (a) dissolving the metal salts in water,
(b) mixing fatty compounds to solution of step (a),
(c) heating the mixture of step (b) to make it homogenous,
(d) adding water soluble burnable agent to the homogenous content of (c) followed by
mixing coloring agents, and fragrance.
2. A process as claimed in claim 1 wherein the metal salts used may be borax, copper sulfate, copper chloride, lithium chloride, lithium bromide, strontium chloride, strontium nitrate, magnesium sulfate, boric acid, calcium chloride, potassium sulfate, potassium nitrate, or combination of these materials.
3. A process as claimed in claims 1 and 2, wherein the fatty compound used may¬be steric acid, steryl alcohol, elainic acid, palmitic acid, lauric acid, caprylic acid, amyl alcohol or combination of these materials.
4. A process as claimed in claims 1 to 3, wherein the water soluble burning agent is prepared from hydroxyl compounds used may be glycerol, inasiiol, glyoxal, ethylene glycol, oxalic acid, succinic acid, ascorbic acid, maleic acid, mannitol, lactic acid, acetic acid, tartaric acid, sorbitol, trioxane, methanol, xylose or combination of these materials.
5. A process as claimed in claims 1 to 4, wherein the coloring agent used may be
edible food grade water soluble dyes like red, yellow, green, blue, orange,
violet or combination of these materials.
6. A process as daisied in claims 1 to 5, wherein the fragrance used may be
fragrances such as rose, sandal, lavender, or combination of
these materials.

Dr. Omprskash Shrinivas Yemul
Dated this 24th day of Sep 2002

Documents:

1050-mum-2001-annxure.pdf

1050-mum-2001-cancelled pages(26-02-2007).pdf

1050-mum-2001-claim(granted)-(10-08-2006).doc

1050-mum-2001-claim(granted)-(10-08-2006).pdf

1050-mum-2001-claims(cancelled).pdf

1050-mum-2001-claims.doc

1050-mum-2001-claims.pdf

1050-mum-2001-correspondence(26-02-2007).pdf

1050-mum-2001-correspondence(ipo)-(09-11-2006).pdf

1050-mum-2001-correspondence(ipo).pdf

1050-mum-2001-correspondence.pdf

1050-mum-2001-description (granted).pdf

1050-mum-2001-description(granted).doc

1050-mum-2001-drawing.pdf

1050-mum-2001-form 1(09-11-2001).pdf

1050-mum-2001-form 1(30-10-2001).pdf

1050-mum-2001-form 1.pdf

1050-mum-2001-form 18(01-09-2005).pdf

1050-mum-2001-form 18.pdf

1050-mum-2001-form 2(granted)-(10-08-2006).doc

1050-mum-2001-form 2(granted)-(10-08-2006).pdf

1050-mum-2001-form 2(granted).doc

1050-mum-2001-form 2(granted).pdf

1050-mum-2001-form 2(title page).pdf

1050-mum-2001-form 3(26-02-2007).pdf

1050-mum-2001-form 3.pdf

1050-mum-2001-form 4(22-10-2002).pdf

1050-mum-2001-form 4.pdf

1050-mum-2001-form 5(29-01-2003).pdf

1050-mum-2001-form 5.pdf

1050-mum-2001-form pct ipea-409(05-07-2004).pdf

1050-mum-2001-isr-pct-isa-210.pdf

1050-mum-2001-pct-ipea-409.pdf

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Patent Number

214918

Indian Patent Application Number

1050/MUM/2001

PG Journal Number

30/2008

Publication Date

25-Jul-2008

Grant Date

18-Feb-2008

Date of Filing

30-Oct-2001

Name of Patentee

SUN PHARMACEUTICAL INDUSTRIES LTD

Applicant Address

ACME PLAZA, ANDHERI-KURLA ROAD, ANDHERI (E), MUMBAI

Inventors:

#	Inventor's Name	Inventor's Address
1	MR. KAMLESH MOHANLAL DUDHARA	SUN PHARMA ADVANCED RESEARCH CENTRE, AKOTA ROAD, AKOTA, BARODA 390 020,
2	Dr. NITIN BHALACLIANDRA DHARAMADHIaraKARI	SUN PHARMACEUTICAL INDUSTRIES LIMITED, ACME PLAZA, ANDHERI-KURLA ROAD, ANDHERI (E), MUMBAI - 400059,

PCT International Classification Number

A61K 9/26

PCT International Application Number

N/A

PCT International Filing date

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1			NA