Title of Invention

PYRROLOTRIAZINE INHIBITORS OF KINASES

Abstract The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the tratment of other diseses associated with signal trasduction pathways operating through growth factor receptors.
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Documents:

in-pct-2001-01414-mum-abstract(8-1-2008).doc

in-pct-2001-01414-mum-abstract(8-1-2008).pdf

in-pct-2001-01414-mum-cancelled pages(8-1-2008).pdf

in-pct-2001-01414-mum-claims(granted)-(8-1-2008).doc

in-pct-2001-01414-mum-claims(granted)-(8-1-2008).pdf

in-pct-2001-01414-mum-correspondence(8-1-2008).pdf

in-pct-2001-01414-mum-correspondence(ipo)-(30-1-2008).pdf

in-pct-2001-01414-mum-form 1(13-11-2001).pdf

in-pct-2001-01414-mum-form 1(19-9-2007).pdf

in-pct-2001-01414-mum-form 13(19-9-2007).pdf

in-pct-2001-01414-mum-form 18(16-11-2005).pdf

in-pct-2001-01414-mum-form 2(granted)-(8-1-2008).doc

in-pct-2001-01414-mum-form 2(granted)-(8-1-2008).pdf

in-pct-2001-01414-mum-form 3(13-11-2001).pdf

in-pct-2001-01414-mum-form 3(19-9-2002).pdf

in-pct-2001-01414-mum-form 5(13-11-2001).pdf

in-pct-2001-01414-mum-form-pct-isa-210(13-11-2001).pdf

in-pct-2001-01414-mum-petition of under rule 137(19-9-2007).pdf

in-pct-2001-01414-mum-power of authority(13-11-2001).pdf

in-pct-2001-01414-mum-power of authority(19-9-2007).pdf


Patent Number 214105
Indian Patent Application Number IN/PCT/2001/01414/MUM
PG Journal Number 13/2008
Publication Date 28-Mar-2008
Grant Date 30-Jan-2008
Date of Filing 13-Nov-2001
Name of Patentee BRISTOL-MYERS SQUIBB CO.
Applicant Address P.O.BOX 4000, PRINCETON, NEW JERSEY 08543-4000.
Inventors:
# Inventor's Name Inventor's Address
1 JOHN T. HUNT. 7 SKYFIELD SR., PRINCETON, NJ 08540.
2 ROBERT M. BRZILLERI 222 RIVEWOODS DR, NEW HOPE, PA 18938.
3 LIGANG QIAN. 11 CONVERNTRY LANE, HOPEWELL, NJ 08525.
4 RAJEEV S. BHIDE, 156 BARNSURY RD., LANGHORNE, PA 19047.
PCT International Classification Number A61K 31/53
PCT International Application Number PCT/US00/13420
PCT International Filing date 2000-05-16
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 60/193,727 2001-03-31 U.S.A.
2 60/135,265 1999-05-21 U.S.A.