Title of Invention

NOVEL 1,2,3-SUBSTITUTED INDOLIZINE DERIVATIVES, INHIBITORS OF FGFS, METHOD FOR MAKING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.

Abstract The invention concerns derivatives of formula (I), wherein R1 represents -OH, (C1-C5) alkoxy, carboxyl, (C2-C6) alkoxycarbonyl, -NR5R6, -NH-SO2-Alk, -NH-SO2-Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-Alk, -NH-CO2-alk,-O-(CH2)n-cAlk, -O-Alk-COOR7,-O-Alk-O-R8,-O-Alk-OH, -O-Alk-C(NH2):NOH, -O-Alk-NR5R6, -O-Alk-CN, -O-(CH2)n-Ph, -O-Alk-CO-NR5R6, -CO-NH-(CH2)m-COOR7, -CO-NH-Alk; R2 represents H, (C1-C5) alkyl, (C1-C5) alkyl halide, (C3-C6) cycloalkyl or phenyl optionally substituted; A represents -CO-, -SO- or -SO2-; R3 and R4 identical or different represent each H, (C1-C5) alcoxyl, amino, carboxy, (C2-C6) alkoxycarbonyl, -OH, nitro, hydroxyamino, -Alk-COOR7, -NR5R6, -NH-Alk-COOR7, -NH-COO-Alk, -N(R11)-SO2-Alk-NR9R10, -N(R11)-SO2-Alk,-N(R11)-Alk-NR5R6, -N(R11)-CO-Alk-NR9R10, -N(R11)-CO-Alk, -N(R11)-CO-CF3, -NH-Alk-HetN, -O-Alk-NR9R10, -O-Alk-CO-NR5R6, -O-Alk-HetN, or R3 and R4 form together an unsaturated heterocycle of 5 to 6 members, optionally in the form of one of their pharmaceutically acceptable salts.
Full Text

Documents:

1212-KOLNP-2004-FORM-27.pdf

1212-kolnp-2004-granted-abstract.pdf

1212-kolnp-2004-granted-assignment.pdf

1212-kolnp-2004-granted-claims.pdf

1212-kolnp-2004-granted-correspondence.pdf

1212-kolnp-2004-granted-description (complete).pdf

1212-kolnp-2004-granted-drawings.pdf

1212-kolnp-2004-granted-examination report.pdf

1212-kolnp-2004-granted-form 1.pdf

1212-kolnp-2004-granted-form 13.pdf

1212-kolnp-2004-granted-form 18.pdf

1212-kolnp-2004-granted-form 3.pdf

1212-kolnp-2004-granted-form 5.pdf

1212-kolnp-2004-granted-gpa.pdf

1212-kolnp-2004-granted-letter patent.pdf

1212-kolnp-2004-granted-reply to examination report.pdf

1212-kolnp-2004-granted-specification.pdf


Patent Number 213959
Indian Patent Application Number 1212/KOLNP/2004
PG Journal Number 04/2008
Publication Date 25-Jan-2008
Grant Date 23-Jan-2008
Date of Filing 19-Aug-2004
Name of Patentee SANOFI - AVENTIS
Applicant Address 174 AVENUE DE FRANCE, F-75013, PARIS
Inventors:
# Inventor's Name Inventor's Address
1 BADORC ALAIN 1, RUE LACANAL, F-31120 ROQUETTES
2 BONO FRANCOISE 21, RUE PHILADELPHE DE GERDE, F-31300TOULOUSE
3 BORDES MARIE-FRANCOISE 367, IMPASSE D'ENROUX, F-31860 LABARTHE SUR LEZE
4 GUILLO NATHALIE 66, QUAI DE TOUNIS, F-31000 TOULOUSE
5 HERBERT JEAN-MARC 10, RUE DE L'AMINDIER, F-31170 TOURNEFEUILLE
PCT International Classification Number A61P 35/00
PCT International Application Number PCT/FR03/01030
PCT International Filing date 2003-04-02
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 02/04220 2002-04-04 France