Title of Invention | NOVEL 1,2,3-SUBSTITUTED INDOLIZINE DERIVATIVES, INHIBITORS OF FGFS, METHOD FOR MAKING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
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Abstract | The invention concerns derivatives of formula (I), wherein R1 represents -OH, (C1-C5) alkoxy, carboxyl, (C2-C6) alkoxycarbonyl, -NR5R6, -NH-SO2-Alk, -NH-SO2-Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-Alk, -NH-CO2-alk,-O-(CH2)n-cAlk, -O-Alk-COOR7,-O-Alk-O-R8,-O-Alk-OH, -O-Alk-C(NH2):NOH, -O-Alk-NR5R6, -O-Alk-CN, -O-(CH2)n-Ph, -O-Alk-CO-NR5R6, -CO-NH-(CH2)m-COOR7, -CO-NH-Alk; R2 represents H, (C1-C5) alkyl, (C1-C5) alkyl halide, (C3-C6) cycloalkyl or phenyl optionally substituted; A represents -CO-, -SO- or -SO2-; R3 and R4 identical or different represent each H, (C1-C5) alcoxyl, amino, carboxy, (C2-C6) alkoxycarbonyl, -OH, nitro, hydroxyamino, -Alk-COOR7, -NR5R6, -NH-Alk-COOR7, -NH-COO-Alk, -N(R11)-SO2-Alk-NR9R10, -N(R11)-SO2-Alk,-N(R11)-Alk-NR5R6, -N(R11)-CO-Alk-NR9R10, -N(R11)-CO-Alk, -N(R11)-CO-CF3, -NH-Alk-HetN, -O-Alk-NR9R10, -O-Alk-CO-NR5R6, -O-Alk-HetN, or R3 and R4 form together an unsaturated heterocycle of 5 to 6 members, optionally in the form of one of their pharmaceutically acceptable salts. |
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1212-kolnp-2004-granted-abstract.pdf
1212-kolnp-2004-granted-assignment.pdf
1212-kolnp-2004-granted-claims.pdf
1212-kolnp-2004-granted-correspondence.pdf
1212-kolnp-2004-granted-description (complete).pdf
1212-kolnp-2004-granted-drawings.pdf
1212-kolnp-2004-granted-examination report.pdf
1212-kolnp-2004-granted-form 1.pdf
1212-kolnp-2004-granted-form 13.pdf
1212-kolnp-2004-granted-form 18.pdf
1212-kolnp-2004-granted-form 3.pdf
1212-kolnp-2004-granted-form 5.pdf
1212-kolnp-2004-granted-gpa.pdf
1212-kolnp-2004-granted-letter patent.pdf
1212-kolnp-2004-granted-reply to examination report.pdf
1212-kolnp-2004-granted-specification.pdf
Patent Number | 213959 | ||||||||||||||||||
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Indian Patent Application Number | 1212/KOLNP/2004 | ||||||||||||||||||
PG Journal Number | 04/2008 | ||||||||||||||||||
Publication Date | 25-Jan-2008 | ||||||||||||||||||
Grant Date | 23-Jan-2008 | ||||||||||||||||||
Date of Filing | 19-Aug-2004 | ||||||||||||||||||
Name of Patentee | SANOFI - AVENTIS | ||||||||||||||||||
Applicant Address | 174 AVENUE DE FRANCE, F-75013, PARIS | ||||||||||||||||||
Inventors:
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PCT International Classification Number | A61P 35/00 | ||||||||||||||||||
PCT International Application Number | PCT/FR03/01030 | ||||||||||||||||||
PCT International Filing date | 2003-04-02 | ||||||||||||||||||
PCT Conventions:
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