Title of Invention

ARYLMETHYLAMINE DERIVATIVES OF FORMULA I AS TRYPTASE INHIBITORS

Abstract Provided herein are compounds of formula (I) wherein R?1-4¿, n and Ar are as defined in claim 1, and their pharmaceutical compositions. These compounds are tryptase inhibitors and may be used in the treatment of e.g. asthma and inflammatory diseases.
Full Text

FIELD OF THE IMVENTIQN This invention is directed to substituted arylmethylamines, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of tryptase.
BACKGROUND OF THE INVENTION
Tryptase is stored in mast cell secretory granules and is the major secretory protease of human mast cells. Tryptase has been implicated in a variety of biological processes, including degradation of vasodilating and bronchorelaxing neuropeptides (Caughey, et al., J. Pharmacol. Exp, Ther., 1988, 244, pages 133-137; Franconi, et al., J. Pharmacol. Exp. Ther., 1988, 248, pages 947-951; and Tarn, et a!., Am, J. Respir. Cell Mol. Biol., 1990, 3, pages 27-32) and modulation of bronchial responsiveness to histamine(Sekizawa,et al., J.Clin. Invest,, 1989, 83, pages 175-179). As a result, tryptase inhibitors may be useful as anti-inflammatory agents (K Rice, P.A. Sprengler, Current Opinion in Drug Discovery and Development, 1999, 2(5), pages 463-474) particularly in the treatment of chronic asthma (M.Q. Zhang, H. Timmerman, Mediators Inflamm., 1997, 112, pages 311-317) and may also be useful in treating or preventing allergic rhinitis (S. J. Wilson et al, Clin. Exp. Allergy, 1998, 28, pages 220-227), inflammatory bowel disease (S.C. Bischoff et al, Histopathology, 1996, 28, pages 1-13), psoriasis (A. Naukkarinen et al. Arch. Dermatol. Res., 1993, 285, pages 341-346), conjunctivitis (A.A.Irani et al, J. Allergy Clin. Immunol., 1990, 86, pages 34-40), atopic dermatitis (A. Jarvikallio et al, Br, J. Dermatol., 1997, 136, pages 871-877), rheumatoid arthritis (L.C Tetlow et al, Ann. Rheum. Dis., 1998, 54, pages 549-555), osteoarthritis (M.G. Buckley et al, J. PathoL, 1998, 186, pages 67-74), gouty arthritis, rheumatoid spondylitis, and diseases of joint cartilage destruction.
In addition, tryptase has been shown to be a potent mitogen for fibroblasts, suggesting its involvement in the pulmonary fibrosis in asthma and interstitial lung diseases (Ruoss et al., J. Clin. Invest., 1991, SS, pages 493-499). Therefore, tryptase inhibitors may be useful in treating or preventing fibrotic conditions (J.A. Cairns and A.F. Walls, J. Clin. Invest., 1997, 99, pages 1313-1321) for example, fibrosis, sceleroderma, pulmonary fibrosis, liver cirrhosis, myocardial fibrosis, neurofibromas and hypertrophic scars.
Additionally, tryptase inhibitors may be useful in treating or preventing myocardial infarction, stroke, angina and other consequences of atherosclerotic plaque rupture (M. Jeziorska et al, J. Pathol., 1997, 182, pages 115-122). Tryptase has also been discovered to activate prostromelysin that in turn activates collagenase, thereby initiating the destruction of cartilage and periodontal connective tissue, respectively. Therefore, tryptase inhibitors could be useful in the treatment or prevention of arthritis, periodontal disease, diabetic retinopathy, and tumor growth (W.J. Beil et al, Exp. Hematol., (1998) 26,

pages 158-169), Also, tryptase inhibitors may be useful in the treatment of anaphylaxis (L.B. Schwarz et al, J. Clin. Invest., 1995, 96, pages 2702-2710), multiple sclerosis (M. Steinhoff et al, Nat. Med. (N, Y.), 2000, 6(2), pages 151-158), peptic ulcers and syncytial viral infections.
Mast cell mediated inflammatory conditions, in particular asthma, are a growing public health concern. Asthma is frequently characterized by progressive development of hyper-responsiveness of the trachea and bronchi to both immunospecific allergens and generalized chemical or physical stimuli, which lead to the onset of chronic inflammation. Leukocytes containing IgE receptors, notably mast cells and basophils, are present in the epithelium and underlying smooth muscle tissues of bronchi. These leukocytes initially become activated by .binding of specific inhaled antigens to the IgE receptors and then release a number of chemical mediators. For example, degranulation of mast cells leads to the release of proteoglycans, peroxidase, arylsulfatase B, tryptase and chymase, which results in bronchiole constriction.
Accordingly, what is needed is a novel and useful group of compounds having valuable pharmaceutical properties, particularly, the ability to inhibit tryptase. Such compounds readily have utility in treating a patient suffering condition that can be ameliorated by the administration of an inhibitor of tryptase, e,g., mast cell mediated inflammatory conditions, inflammation, and diseases or disorders related to the degradation of vasodilating and bronchorelaxing neuropeptides. Particular examples of such conditions are described infra.
The citation of any reference herein should not be construed as an admission that such reference is available as -Prior Art- to the instant application.



wherein:-
is a single or a double bond;
R 1 and R2 are each independently hydrogen or lower alkyl;
R3 is aryl, arylalkenyl, cycloalkenyl, cycloalkyl, heteroaryl, heteroarylalkenyl, heterocycloalkenyl, a carbon linked heterocycloalkyl or alkyl optionally substituted by one or more groups selected from
hydroxy, alkoxy, alkyloxycarbonylamino, cycloalkyl, heterocycloalkyl, R-, -OR-, -S(0)j-R- or
-C(-0)-R6;
R- is hydrogen, acyl, alkoxy, alkyloxycarbonyl, carboxy, cyano, halo, hydroxy, -C(=0)-NY- Y- or alkyl optionally substituted with alkoxy, alkylcarbonylamino, alkylsulfonylamino, hydroxy,
-S(0)m-alkylor-NY*Y2;
R5 is hydrogen, acyl, alkoxy, alkyloxycarbonyl, aryl, carboxy, cyano, halo, heteroaryl, heteroaryloxy, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylalkyloxy, heteroarylalkyioxy, hydroxy,
trifluoromethyl, -C(-0)-NYW2, -NY1 Y2, -Zl-C2-6alkylene-R'7 or alkyl optionally substituted with
alkoxy, alkylcarbonylamino, alkylsulfonylamino, aryl, heteroaryl, heterocycloalkyl, hydroxy, ureido,
-C(-0)->JY W2, -S02-NYW2, -S(0)jTi-alkyl or -NY1Y2;
R6 is aryl or heteroaryl;
R7 is hydroxy, alkoxy, ureido, -C(=0)-NY1 Y2 -SO2-NY1Y2, -S(0)m-'alkyl or -NY1 Y2;
R8 is hydrogen or lower alkyl;
Y1 andY2 are independently hydrogen, alkenyl, alkyl, aryl, aryialkyl, cycloalkyl, heteroaryl,
heteroarylalkyl or heterocycloalkyl; or the group -NY
1Y2
may form a cyclic amine; Z' isO, S(O)m0rNR8;
m is zero or an integer 1 to 2;
n is zero or an integer 1 to 4;
an N-oxide of said compound, a prodrug of said compound, a pharmaceutical ly acceptable salt of said
compound, a solvate of said compound, and a hydrate of said compound.
Furthermore, the present invention extends to a compound of formula (la): -


wherein:-
is a single or a double bond;
R1 andR2 are each independently hydrogen or lower alkyl;
R3 is aryl, arylalkenyl, cycloalkenyl, cycloalkyl, heteroaryl, heteroarylalkenyl, heterocycloalkenyl, a carbon linked heterocycloalkyl or alkyl optionally substituted by one or more groups selected from
hydroxy, alkoxy, alkyloxycarbonylamino, cycloalkyl, heterocycloalkyl, R6, -OR6, -S(0),mR6 or
-C(=0)-R6;
R4 is hydrogen, acyl, alkoxy, alkyloxycarbonyl, carboxy, cyano, halo, hydroxy, -C(=0)-NYW2 or alkyl optionally substituted with alkoxy, alkylcarbonylamino, alkylsulfonylamino, hydroxy, -S(0)m-alkylor-NYW2;
R- is hydrogen, acyl, alkoxy, alkyloxycarbonyl, aryl, carboxy, cyano, halo, heteroaryl, heteroaryloxy, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylalkyloxy, heteroarylalkyloxy, hydroxy,
trifluoromethyl, -C(=0)-NYW2, -NY1Y2, -Z1-C2.6alkylene-R'7 or alkyl optionally substituted with
alkoxy, alkylcarbonylamino, alkylsulfonylamino, aryl, heteroaryl, heterocycloalkyl, hydroxy, ureido,
-C(=0)-NYW2, -S02-NY1Y2, -S(0)m-alkyl or -NY1Y2;
R6 is aryl or heteroaryl;
R'7 is hydroxy, alkoxy, ureido, -C(-0)-NY1Y2, .SO2-NYIY2, -S(0)m-alkyl or -NY1 Y2;
R8 is hydrogen or lower alkyl;
Y1 and Y2 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl,
heteroarylalkyl or heterocycloalkyl; or the group -NYY2 may form a cyclic amine;

Z1 isO, S(0)m or NR8;
m is zero or an integer 1 to 2;
n is zero or an integer 1 to 4;
and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and
solvates (e.g, hydrates) of such compounds and their N-oxides and prodrugs,
2. In another embodiment, the present invention extends to a compound of formula (lb):
wherein
R3 is aryl, arylalkenyl, cycloalkenyl, cycloalkyl, heteroaryl, heteroarylaikenyl, heterocycloalkenyl, a carbon linked heterocycloalkyi or alkyl optionally substituted by one or more groups selected from
hydroxy, alkoxy, alkyloxycarbonylamino, cycloalkyl, heterocycloalkyi, R6, -OR6, -S(0)j-R- or
-C(-0)-R6;
R4 is hydrogen, acyl, alkoxy, alkyloxycarbonyl, carboxy, cyano, halo, hydroxy, -C(=0)-NY-Y2 or alky! optionally substituted with alkoxy, alkylcarbonylamino, alkylsulfonylamino, hydroxy,
-S(0)|-n-alkyl or -NY 1 Y2; and
R- is hydrogen, acyl, alkoxy, alkyloxycarbonyl, aryl, carboxy, cyano, halo, heteroaryl, heteroaryloxy, heterocycloalkyi, heterocycloalkyloxy, heterocycloalkylalkyloxy, heteroarylalkyloxy, hydroxy,
trifluoromethyl, -C(-0)-NY1 Y-, -NYW-, -Zl-C2_6alkylene-R- or alkyl optionally substituted with
alkoxy, alkylcarbonylamino, alkylsulfonylamino, aryl, heteroaryl, heterocycloalkyi, hydroxy, ureido,
-C(-0)-NYIY2, -S02-NYW2, -S(0)m-alkyl or-NY1Y2, and,
a corresponding N-oxide of said compound, a prodrug of said compound, a pharmaceutically acceptable salt of said compound, a solvate of said compound, an N-oxides and prodrugs.
Particular examples of such compounds are described infra.

Furthermore, the present invention extends to a pharmaceutical composition comprising a compound of the present invention, as described above, and a pharmaceutical ly acceptable carrier thereof. Numerous examples of pharmaceutical carriers having applications in the present invention are described infra.
In addition, the present invention extends to a method for treating a patient suffering from a condition that can be ameliorated by the administration of an inhibitor of tryptase, comprising administering an effective amount of a compound of a compound of the present invention. An example of a condition that can be treated with a compound of the present invention includes, but certainly is not limited to inflammatory diseases, e.g., joint inflammation, arthritis, rheumatoid arthritis, rheumatoid spondylitis, gouty arthritis, traumatic arthritis, rubella arthritis, psoriatic arthritis, and other chronic inflammatory joint diseases. Other examples of conditions that can be treated with a method of the present invention include diseases of joint cartilage destruction, ocular conjunctivitis, vernal conjunctivitis, inflammatory bowel disease, asthma, allergic rhinitis, interstitial lung diseases, fibrosis, sceleroderma, pulmonary fibrosis, liver cirrhosis, myocardial fibrosis, neurofibromas, hypertrophic scars, various dermatological conditions, for example, atopic dermatitis and psoriasis, myocardial infarction, stroke, angina and other consequences of atherosclerotic plaque rupture, as well as periodontal disease, diabetic retinopathy, tumor growth, anaphylaxis, multiple sclerosis, peptic ulcers, and syncytial viral infections, to name only a few.
In a particular embodiment, the present invention extends to a method of treating a subject suffering from asthma, comprising administering to the subject an effective amount of a compound of the present invention.
In another embodiment, the present invention extends to a method for treating a patient suffering from joint inflammation, comprising administering to the patient an effective amount of a compound of the present invention.
In addition, the present invention extends to a pharmaceutical comprising a compound of the present invention, a second compound selected from the group consisting of a beta andrenergic agonist, an anticholinergic, an anti-inflammatory corticosteroid, and an anti-inflammatory agent, and a pharmaceutically acceptable carrier thereof Particular inflammatory diseases or disorders that can be treated with such a pharmaceutical composition includes, but certainly is not limited to asthma.
Moreover, the present invention extends to a method for treating a patient suffering from an inflammatory disorder, comprising administering to the patient a compound of the present invention and a second compound selected from the group consisting of a beta andrenergic agonist, an

anticholinergic, an anti-inflammatory corticosteroid, and an anti-inflammatory agent. In such a method of the present invention, a compound of the present invention can be administered to the patient before a second compound, a second compound can be administered to the patient before a compound of the present invention, or a compound of the present invention and a second compound can be administered concurrently. Particular examples of andrenergic agonists, anticholinergics, anti¬inflammatory corticosteroids, and anti-inflammatory agents having applications in a method of the present invention are described infra.
Accordingly, it is a principal object to provide compounds having an anti-tryptase activity. Such compounds can readily be used to treat a condition that can be ameliorated by the administration of an inhibitor of tryptase.
It is another object of the present invention to provide pharmaceutical compositions for treating a condition that can be ameliorated by the administration of an inhibitor of tryptase.
It is yet another object of the present invention to provide pharmaceutical compositions comprising a compound of the present invention.
These and other aspects of the present invention will be better appreciated by reference to the following Detailed Description.
DETAILED DESCRIPTION As used above, and throughout the instant specification and appending claims, the following terms, unless otherwise indicated, shall be understood to have the following meanings:-
As used herein, the term -compounds of the present invention-, and equivalent expressions, are meant to embrace compounds of formulae (I), (la), or (lb) as hereinbefore described, which expression includes the prodrugs, the pharmaceutically acceptable salts and the solvates, e.g. hydrates, where the context so permits. Similarly, reference to intermediates, whether or not they themselves are claimed, is meant to embrace their salts, and solvates, where the context so permits. For the sake of clarity, particular instances when the context so permits are sometimes indicated in the text, but these instances are purely illustrative and it is not intended to exclude other instances when the context so permits.
As used herein, the term -treatment- includes prophylactic therapy as well as treatment of an established condition.

-Patient'* includes both human and other mammals.
'-Effective amount' is meant to describe an amount of compound of the present invention effective in inhibiting tryptase and thus producing the desired therapeutic effect.
-Acyl- means an H-CO- or alkyl-CO- group in which the alkyl group is as described herein.
-Acylamino- is an acyl-NH- group wherein acyl is as defined herein.
-Alkenyl- means an aliphatic hydrocarbon group containing a carbon-carbon double bond and which may be straight or branched having about 2 to about 15 carbon atoms in the chain. Preferred alkenyl groups have 2 to about 12 carbon atoms in the chain; and more preferably about 2 to about 4 carbon atoms in the chain. -Branched-, as used herein and throughout the text, means that one or more lower alkyl groups such as methyl, ethyl or propyl are attached to a linear chain; here a linear alkenyl chain. -Lower alkenyl- means about 2 to about 4 carbon atoms in the chain that may be straight or branched. Exemplary alkenyl groups include ethenyl, propenyl, n-butenyl, i-butenyl, 3-methylbut-2-enyl, n-pentenyl, heptenyl, octenyl and decenyl.
-Alkoxy- means an alkyl-O- group in which the alkyl group is as described herein. Exemplary alkoxy groups include methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy and heptoxy,
-Alkyloxycarbonyl- means an alkyl-O-C(=O)- group in which the alkyl group is as described herein. Exemplary alkyloxycarbonyl groups include methoxy- and ethoxycarbonyl.
-Alkyl- means, unless otherwise specified, an aliphatic hydrocarbon group which may be straight or branched having about 1 to about 15 carbon atoms in the chain optionally substituted by alkoxy or by one or more halogen atoms. Particular alkyl groups have from 1 to about 6 carbon atoms. -Lower alkyl- as a group or part of a lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl group means unless otherwise specified, an aliphatic hydrocarbon group which may be straight or branched having about I to about 4 carbon atoms in the chain. Exemplary alkyl groups include methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, t-butyl, n-pentyl, 3-pentyl, heptyl, octyl, nonyl, decyl and dodecyl.
-Alkylcarbonylamino- means an alkyl-C(=0)-NH- group in which the alkyl group is as described herein. Exemplary alkylcarbonylamino groups include acetamido and propionamido.

-Alkylene- means an aliphatic bivalent radical derived from a straight or branched alkyl group, in which the alkyl group is as described herein. Exemplary alkylene radicals include methylene, ethylene and trimethylene.
-Alkylenedioxy- means an -O-alkyl-0- group in which the alkyl group is as defined above. Exemplary alkylenedioxy groups include methylenedioxy and ethylenedioxy.
-Alkylsulfmyl- means an alkyl-SO- group in which the alkyl group is as previously described. Preferred alkylsulfinyl groups are those in which the alkyl group is C].4alkyl.
-Alkylsulfonyl- means an alkyl-S02- group in which the alkyl group is as previously described. Preferred alkylsulfonyl groups are those in which the alkyl group is C1-4alkyl.
-Alkylsulfonylamino- means an alkyl-S02-NH- group in which the alkyl group is as described herein. Exemplary alkylsulfonylamino groups include methanesulfonamido and ethanesulfonamido.
-Alkylthio- means an alkyl-S- group in which the alkyl group is as previously described. Exemplary alkylthio groups include methylthio, ethyithio, isopropylthio and heptylthio.
-Alkynyl- means an aliphatic hydrocarbon group containing a carbon-carbon triple bond and which may be straight or branched having about 2 to about 15 carbon atoms in the chain. Preferred alkynyl groups have 2 to about 12 carbon atoms in the chain; and more preferably about 2 to about 4 carbon atoms in the chain. Exemplary alkynyl groups include ethynyl, propynyl, n-butynyl, 2-butynyl, 3-methylbut-2-ynyl, and n-pentynyl.
-Aroyl- means an aryl-CO- group in which the aryl group is as described herein. Exemplary aroyl groups include benzoyl and 1- and 2-naphthoyl.
-Aroylamino- is an aroyl-NH- group wherein aroyl is as previously defined.
-Aryl- as a group or part of a group denotes: (i) an optionally substituted monocyclic or multicyclic aromatic carbocyclic moiety of about 6 to about 14 carbon atoms, such as phenyl or naphthyl; or (ii) an optionally substituted partially saturated multicyclic aromatic carbocyclic moiety in which an aryl and a cycioalkyl or cycloalkenyl group are fused together to form a cyclic structure, such as a tetrahydronaphthyl, indenyl or indanyl ring. Aryl groups may be substituted with one or more aryl group substituents which may be the same or different, where -aryl group substituent- includes, for

example, acyl, acylamino, alkoxy, alkyloxycarbonyl, alkyienedioxy, alkylsulfinyl, alkyisuifonyl, alkylthio, aroyl, aroylamino, aryl, arylalkenyl, arylalkynyl, arylalkyloxy, arylalkyloxycarbonyl, arylalkylthio, aryloxy, aryloxyalkyl, aryloxycarbonyl, arylsulfinyl, arylsulfonyl, arylthio, carboxy, cyano, halo, heteroaroyi, heteroaryl, heteroarylalkenyl, heteroarylalkynyl, heteroarylalkyloxy,
heteroaroylamino, heteroaryloxy, heteroaryloxyalkyl, hydroxy, nitro, trifluoromethyl, -NY1Y2, -CONY W2, -SO2NY -2- -Z2-C2-6alkylene-NYl Y2 {where Z2 is O, NR8 or S(0)m},
-NY--(C=0)alkyI, -NY--S02aIkyl or alkyl optionally substituted with alkoxy, aroyl, aryl, aryloxy, heteroaryl, hydroxy, or -NYW-.
-Arylalkenyl- means an aryl-alkenyl- group in which the aryl and alkenyl are as previously described. Preferred arylalkenyls contain a lower alkenyl moiety. Exemplary arylalkenyl groups include styryl and phenylallyl.
-Arylalkyl- means an aryl-alkyl- group in which the aryl and alkyl moieties are as previously described. Preferred arylalkyl groups contain a C1-4alkyl moiety. Exemplary arylalkyl groups
include benzyl, 2-phenethyl and naphthlenemethyl.
-Arylalkyloxy- means an arylalkyl-O- group in which the arylalkyl groups is as previously described. Exemplary arylalkyloxy groups include benzyloxy and 1- or 2-naphthalenemethoxy.
-Arylalkyloxycarbonyl- means an arylalkyl-0-CO- group in which the arylalkyl groups is as previously described. An exemplary arylalkyloxycarbonyl group is benzyloxycarbonyl.
-Arylalkylthio- means an arylalkyl-S- group in which the arylalkyl group is as previously described. An exemplary arylalkylthio group is benzylthio.
-Arylalkynyl- means an aryl-alkynyl- group in which the aryl and alkynyl are as previously described. Exemplary arylalkynyl groups include phenylethynyl and 3-phenylbut-2-ynyl.
-Aryloxy- means an aryl-O- group in which the aryl group is as previously described. Exemplary aryloxy groups include optionally substituted phenoxy and naphthoxy.
-AryloxyalkyI- means an aryl-O-alkyI- group in which the aryl and alkyl groups are as previously described. Exemplary aryloxyalkyi groups include phenoxymethyl and 1- or 2-naphthyloxymethyl.

-Aryloxycarbonyl- means an aryl-0-C(=0)- group in which the aryl group is as previously described. Exemplary aryloxycarbonyl groups include phenoxycarbonyl and naphthoxycarbonyl.
-Arylsulfmyl- means an ary!-SO- group in which the aryl group is as previously described.
-Arylsulfonyl- means an aryl-S02- group in which the aryl group is as previously described.
-Arylthio- means an aryl-S- group in which the aryl group is as previously described. Exemplary arylthio groups include phenylthio and naphthylthio.
-Azaheteroaryl- means an aromatic carbocyclic moiety of about 5 to about 10 ring members in which one of the ring members is nitrogen and the other ring members are chosen from carbon, oxygen, sulfur, or nitrogen. Examples of azaheteroaryl groups include benzimidazolyl, imidazolyl, isoquinolinyl, isoxazolyl, pyrazolopyrimidinyl, pyridyl, pyrimidinyl, quinolinyl, quinazolinyl and thiazolyl.
-Cyclic amine- means a 3 to 8 membered monocyclic cycloalkyl ring system where one of the ring carbon atoms is replaced by nitrogen and which (i) may optionally contain an additional heteroatom
selected from O, S or NY3 (where Y3 is hydrogen, alkyl, arylalkyl, and aryl) and (ii) may be fused to additional aryl or heteroaryl ring to form a bicyclic ring system. Exemplary cyclic amines include pyrrolidine, piperidine, morpholine, piperazine, indoline and pyrindoline.
-Cycloalkenyl- means a cycloalkyl group containing at least one carbon-carbon double bond. Exemplary monocyclic cycloalkenyl rings include cyclopentenyl, cyclohexenyl or cycloheptenyl.
-Cycloalkyl- means a saturated monocyclic or bicyclic ring system of about 3 to about 10 carbon
atoms optionally substituted by oxo, alkyl, aryl or-C(-0)-NY'Y2. Exemplary monocyclic cycloalkyl rings include C-.gcycloalkyl rings such as cyclopropyl, cyclopentyl, cyclohexyl and cycloheptyl.
-Cycloalkylalkyl- means a cycloalkyl-alkyl- group in which the cycloalkyl and alkyl moieties are as previously described. Exemplary monocyclic cycloalkylalkyl groups include cyclopropylmethyl, cyclopentylmethyl, cyclohexylmethyl and cycloheptylmethyl.
-Halo- or -halogen- means fluoro, chloro, bromo, or iodo. Preferred are fluoro or chloro.

-Heteroaroyl- means a heteroaryl'C(-O)- group in which the heteroaryl group is as described herein. Exemplary groups include pyridylcarbonyl.
-Heteroaroylamino- means a heteroaroyl-NH- group in which the heteroaryl moiety are as previously described.
-Heteroaryl- as a group or part of a group denotes: (i) an optionally substituted aromatic monocyclic or multicyclic organic moiety of about 5 to about 10 ring members in which one or more of the ring members is/are element(s) other than carbon, for example nitrogen, oxygen or sulfur (examples of such groups include benzimidazolyl, benzthiazolyl, benzthiophenyl, furyl, imidazolyl, indolyl, indolizinyl, isoxazolyl, isoquinolinyl, isothiazolyl, oxadiazolyl, pyrazinyl, pyridazinyl, pyrazolyl, pyridyl, pyrimidinyK pyrrolyl, quinazolinyl, quinolinyl, 1,3,4-thiadiazolyl, thiazolyl, thienyl and triazolyl groups, optionally substituted by one or more aryl group substituents as defined above); (ii) an optionally substituted partially saturated muhicyclic heterocarbocyclic moiety in which a heteroaryl and a cycloalkyl or cycloalkenyl group are fused together to form a cyclic structure (examples of such groups include pyrindanyl groups). Optional substituents include one or more -aryl group substituents- as defined above.
'Aryldiyl- means an optionally substituted bivalent radical derived from an aryl group as defined herein. Exemplary aryldiyi groups include optionally substituted phenylene, naphthylene and indanylene. Suitable substituents include one or more -aryl group substituents- as defined above, particularly halogen, methyl or methoxy.
-HeteroaryldiyI- means a bivalent radical derived from a heteroaryl group as defined below.
-Heteroarylalkenyl- means a heteroaryl-alkenyl- group in which the heteroaryl and alkenyl moieties are as previously described. Preferred heteroarylalkenyl groups contain a lower alkenyl moiety. Exemplary heteroarylalkenyl groups include pyridylethenyl and pyridylallyK
-Heteroarylalkyl- means a heteroaryl-alkyi- group in which the heteroaryl and alkyl moieties are as previously described. Preferred heteroarylalkyl groups contain a C|-4alkyl moiety. Exemplary
heteroarylalkyl groups include pyridyimethyf
-Heteroarylalkyloxy- means an heteroarylalkyl-0- group in which the heteroarylalkyl group is as previously described. Exemplary heteroaryloxy groups include optionally substituted pyridylmethoxy.

-Heteroarylalkynyl- means a heteroaryl-alkynyl- group in which the heteroaryl and alkynyl moieties are as previously described. Exemplary heteroarylalkenyl groups include pyridylethynyl and 3-pyridylbut-2-ynyI.
-Heteroaryloxy- means an heteroaryl-O- group in which the heteroaryl group is as previously described. Exemplary heteroaryloxy groups include optionally substituted pyridyloxy.
-Heteroaryloxyalkyl- means an heteroaryl-0-alkyl- group in which the heteroaryl and alkyl groups are as previously described. Exemplary heteroaryloxyalkyl groups include pyridyoxymethyl and 2-, 3- or 4-quinolinyloxymethyl.
-Heterocycloalkenyl- means a cycloalkenyl group of about 3 to 7 ring members which contains one or
more heteroatoms selected from O, S or NY4 (where Y4 is hydrogen, alkyl, aryl, arylalkyl, and alkyloxycarbonyl). Exemplary heterocycloalkenyl groups include 1,2,3,6-tetrahydro-pyridine.
-Heterocycloalkyl- means: (i) a cycloalkyl group of about 3 to 7 ring members which contains one or
more heteroatoms selected from O, S or NY4 (where Y4 is hydrogen, alkyl, aryl,- arylalkyl, and alkyloxycarbonyl) and which may optionally be substituted by oxo (examples of such groups include piperidinyl, pyrrolidinyl, morpholinyl, tetrahydropyranyl and tetrahydrothiophenyl; (ii) an optionally substituted partially saturated muUicyclic heterocarbocyclic moiety in which one or more aryl (or heteroaryl) rings and a cycloalkyl group of about 3 to 7 ring members, which contains one or more
heteroatoms selected from O, S or NY-* and which may optionally be substituted by oxo, are fused together to form a cyclic structure (examples of such groups include chromanyl, dihydrobenzofuranyl, indolinyi and pyrindolinyl groups).
-Heterocycloalkylalkyl- means a heterocycloalkyl-alkyl- group in which the heterocycloalkyl and alkyl moieties are as previously described.
-Heterocycloalkylalkyloxy- means a heterocycloalkyl-alkyl-0- group in which the heterocycloalkyl and alkyl moieties are as previously described.
-Heterocycloalkyloxy- means a heterocycloalkyl-O- group in which the heterocycloalkyl is as previously described.
-Prodrug- means a compound which is suitable for administration to a patient without undue toxicity, irritation, allergic response, and the like, and is convertible in vivo by metabolic means (e.g. by

hydrolysis) to a compound of the present invention, including N-oxides thereof. A thorough discussion is provided in T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, Vol. 14 of the A. C. S. Symposium Series, and in Edward B. Roche, ed., Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987, both of which are incorporated herein by reference. For example an ester of a compound of the present invention containing a hydroxy group may be convertible by hydrolysis in vivo to the parent molecule. Alternatively an ester of a compound of the present invention containing a carboxy group may be convertible by hydrolysis in vivo to the parent molecule.
Suitable esters of compounds of present invention containing a hydroxy group, are for example acetates, citrates, lactates, tartrates, maionates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-p-hydroxynaphthoates, gentisates, isethionates, di-p-toluoyltartrates, methanesulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, cyclohexylsulfamates and quinates.
An especially useful class of esters of compounds of the present invention containing a hydroxy group, may be formed from acid moieties selected from those described by Bundgaard et al,, J. Med. Chem., 1989, 32, page 2503-2507, and include substituted (aminomethyl)-benzoates, for example dialkylamino-methylbenzoates in which the two alkyl groups may be joined together and/or interrupted by an oxygen atom or by an optionally substituted nitrogen atom, e.g. an alkylated nitrogen atom, more especially (morpholino-methyl)benzoates, e.g. 3- or 4-(morpholinomethyl)-benzoates, and (4-alkylpiperazin-l-yl)benzoates, e.g. 3- or 4-(4-alkylpiperazin-l-yl)benzoates.
Suitable esters of compounds of the present invention containing a carboxy group, are for example those described by F.J.Leinweber, Drug Metab. Res., 1987,18, page 379.
The compounds of the present invention are basic, and such compounds are useful in the form of the free base or in the form of a pharmaceutically acceptable acid addition salt thereof
Acid addition salts are a more convenient form for use; and in practice, use of the salt form inherently amounts to use of the free base form. The acids which can be used to prepare the acid addition salts include preferably those which produce, when combined with the free base, pharmaceutically acceptable salts, that is, salts whose anions are non-toxic to the patient in pharmaceutical doses of the salts, so that the beneficial inhibitory effects inherent in the free base are not vitiated by side effects ascribable to the anions. Although pharmaceutically acceptable salts of said basic compounds are preferred, all acid addition salts are useful as sources of the free base form even if the particular salt, per se, is desired only as an intermediate product as, for example, when the salt is formed only for

purposes of purification, and identification, or when it is used as intermediate in preparing a pharmaceutically acceptable salt by ion exchange procedures. Pharmaceutically acceptable salts within the scope of the invention include those derived from mineral acids and organic acids, and include hydrohalides, e.g. hydrochlorides and hydrobromides, sulfates, phosphates, nitrates, sulfamates, acetates, citrates, lactates, tartrates, malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-b-hydroxynaphthoates, gentisates, isethionates, di-p-toluoy I tartrates, methane-sulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, cyciohexylsulfamates and quinates.
As well as being useful in themselves as active compounds, salts of compounds of the invention are useful for the purposes of purification of the compounds, for example by exploitation of the solubility differences between the salts and the parent compounds, side products and/or starting materials by techniques well known to those skilled in the art.
With reference to formula (la) above, the following are particular and preferred groupings:
R- may particularly represent hydrogen.
R2 may particularly represent hydrogen.
R3 may particularly represent aryl, such as optionally substituted phenyl or optionally substituted naphthy], especially substituted phenyl. Exemplary optional substituents include one or more halo atoms or alkyl substituted by aryl, alkyl substituted by aryloxy, alkyl substituted by aroyl, alkyl substituted by heteroaryl, arylalkynyl, heteroarylalkynyi, aryl, heteroaryl, arylalkenyl or arylalkyloxy, in which the aryl or heteroaryl groups may be further substituted by one or more aryl group substituents.
may also particularly represent heteroaryl, such as optionally substituted pyridyl, optionally substituted quinolinyl, optionally substituted thienyl, optionally substituted furanyl or optionally substituted indolyl, especially substituted thienyl, substituted pyridyl or indolyl. Exemplary optional substituents include alkyl substituted by aryl, alkyl substituted by aryloxy, alkyl substituted by aroyl, alkyl substituted heteroaryl, arylalkynyl, heteroarylalkynyi, heteroaryl, arylalkenyl or arylalkyloxy, in which the aryl or heteroaryl groups are further substituted by one or more aryl group substituents.
R*- may particularly represent hydrogen.

R4 may also particularly represent cyano, especially when attached to the tertiary ring carbon atom, may particularly represent hydrogen.
may also particularly represent lower alkyl (e.g. methyl) or halo (e.g. fluoro).
may particularly represent a single bond.
n may particularly represent 2.
It is to be understood that this invention covers all appropriate combinations of the particular and preferred groupings referred to herein.
A particular group of compounds of the invention are compounds of formula (Ib):-

in which R3, R4 and R5 are as hereinbefore defined and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and prodrugs.
Compounds of formula (lb) in which R3 represents aryl, such as optionally substituted phenyl or optionally substituted naphthyl, especially substituted phenyl, are preferred. Preferred optional substituents include one or more halo atoms or alkyl substituted by aryl or alkyl substituted heteroaryl, in which the aryl or heteroaryl groups may be further substituted by one or more aryl group
substituents. R3 especially represents dichlorophenyl [e.g. 3,4-dichlorophenyl],

phenylC1-3alkylphenyl [e.g. phenethyl], hydroxyphenylCi_3alkylpheiiyl [e.g. 4-hydroxyphenylethyIphenyl] and aminopyridylCi_3alkylphenyl [e.g. (4-amino-pyrid-3-yl)ethylphenyl].
Compounds of formula (lb) in which R3 represents heteroaryl, such as optionally substituted pyridyl, optionally substituted quinolinyl, optionally substituted thienyl, optionally substituted furanyl or optionally substituted indolyl, especially substituted thienyl, substituted pyridyl or indolyl, are preferred. Preferred optional substituents include alkyl substituted by aryl and alkyl substituted heteroaryl in which the aryl or heteroaryl groups are further substituted by one or more aryl group
substituents. R- especially represents phenylC],3alkylpyridyl [e.g. 5-phenylethyl-pyrid-3-yl],
phenylC|.3alkyhhienyl [e.g. 5-phenylethyl-thien-2-yl] and indolyl [e.g. indol-6-yll.
Compounds of formula (lb) in which R4 represents hydrogen are preferred.
Compounds of formula (lb) in which R4 represents cyano are also preferred. R4 is preferably attached at the 4 position of the piperidine ring.
Compounds of formula (lb) in which R5 represents hydrogen are preferred.
Compounds of formula (lb) in which R5 represents lower alkyl (e.g. methyl) or halo (e.g. fluoro), are also preferred. R5 is preferably attached to the phenyl ring in the position para to the -CH2NH2 group.
A preferred group of compounds of the invention are compounds of formula (lb) in which:- R3is substituted phenyl [especially 3,4-dichlorophenyl, phenethyl, 4-hydroxyphenylethylphenyl and (4-amino-pyrid-3-yl)ethylphenyl] or optionally substituted heteroaryl [ especially 5-phenylethyl-pyrid-3-
yl, 5-phenylethyl-thien-2-yl or indol-6-yl]; R4 is hydrogen, or cyano attached at the 4 position of the
piperidine ring; R5 is hydrogen, or lower alkyl (e.g. methyl) or halo (e.g. fluoro) attached to the phenyl ring in the position para to the -CH2NH2 group; and the corresponding N-oxides, and their prodrugs;
and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and prodrugs.
Particular compounds of the invention are selected from the compounds formed by joining the carbon atom (C*) of one of the fragments (Al to AlO) shown in Table 1 to the carbon atom (C*) of one of the fragments (Bl to B12) shown in Table 2, and joining the nitrogen atom (N*) of one of the fragments

(Bl to B12) shown in Table 2 to the carbon atom (C*) of one of the acidic fragments (C1 to CI 03) depicted in Table 3.



























TABLE 4
Al-Bl-Cl A1-B1-C2 A1-B1-C3 A1-B1-C4 A1-B1-C5 A1-B1-C6
Al-B)-C7 A1-B1-C8 A1-B1-C9 Al-Bl-ClO Al-Bl-Cll A1-B1-C12
A1-B1-C13 A1-B1-C14 A1-B1-C15 A1-B1-C16 A1-B1-C17 A1-B1-C18
A1-B1-C19 A1-B1-C20 A1-B1-C21 A1-BI-C22 A1-B1-C23 A1-B1-C24
A1-B1-C25 A1-B1-C26 A1-B1-C27 A1-B1-C28 A1-B1-C29 A1-B1-C30
A1-B1-C31 A1-B1-C32 A1-B1-C33 A1-B1-C34 A1-B1-C35 A1-B1-C36
A1-B1-C37 A1-BI-C38 A1-B1-C39 A1-B1-C40 A1-B1-C41 A1-B1-C42
A1-B1-C43 A1-B1-C44 A1-B1-C45 A1-B1-C46 A1-B1-C47 A1-B1-C48
A1-B1-C49 A1-B1-C50 A1-B1-C51 A1-B1-C52 A1-B1-C53 A1-B1-C54
A1-BI-C55 A1-B1-C56 A1-B1-C57 AI-B1-C58 Al-B)-C59 A1-B1-C60
A1-B1-C61 A1-B1-C62 A1-B1-C63 A1-B1-C64 A1-B1-C65 AI-BI-C66
A1-B1-C67 A1-B1-C68 A1-B1-C69 A1-B1-C70 A1-B1-C71 A1-B1-C72
A1-BI-C73 A1-B1-C74 A1-B1-C75 A1-B1-C76 A1-B1-C77 A1-B1-C78
A1-B1-C79 A1-B1-C80 A1-B1-C8I AI-B1-C82 A1-B1-C83 A1-B1-C84
A1-B1-C85 A1-B1-C86 A1-B1-C87 A1-B1-C88 A1-B1-C89 A1-B1-C90
A1-B1-C91 A1-B1-C92 A1-B1-C93 A1-B1-C94 A1-B1-C95 A1-B1-C96
A1-B1-C97 A1-B1-C98 AI-BI-C99 Al-Bl-ClOO Al-Bl-ClOl Al-Bl-cl02
A1-B1-C103 A1-B1-C104 A1-B1-C105 A1-B1-C106 A1-B1-C107 A1-B1-C108
AI-B1-C109 Al-Bl-CnO Al-Bl-Clll Al-Bl-Cn2 A1-B1-C113 Al-Bl-CIH

A1-B1-C115 A1-B1-C116 A1-B1-C117 A1-B1-C118 Al-BI-Cl 19 A1-B1-CI20
A1-B1-C121 A1-B1-C122 A1-BI-C123 A1-B1-C124 A1-B1-C125 AI-B1-C]26
A1-B1-CI27 A1-B1-C128 A1-B1-C129 A1-B1-C130 A1-B1-C131 A1-B1-C132
A1-B1-C133 A1-B1-C134 A1-B1-C135 A1-B1-C136 A1-B1-C137 A1-B1-C138
AI-Bl-CI 39 A1-B1-C140 BLANK BLANK BLANK BLANK
A1-B2-C1 A1-B2-C2 A1-B2-C3 A1-B2-C4 A1-B2-C5 A1-B2-C6
A1-B2-C7 A1-B2-C8 A1-B2-C9 A1-B2-C10 A1-B2-C11 A1-B2-C12
A1-B2-C13 A1-B2-C14 A1-B2-C15 A1-B2-C16 A1-B2-C17 A1-B2-C18
A1-B2-C19 A1-B2-C20 A1-B2-C21 A1-B2-C22 A1-B2-C23 A1-B2-C24
A1-B2-C25 A1-B2-C26 AI-B2-C27 AI-B2-C28 A1-B2-C29 A1-B2-C30
A1-B2-C3] A1-B2-C32 A1-B2-C33 A1-B2-C34 A1-B2-C35 A1-B2-C36
A1-B2-C37 A1-B2-C38 A1-B2-C39 A1-B2-C40 A1-B2-C41 A1-B2-C42
A1-B2-C43 A1-B2-C44 A1-B2-C45 A1-B2-C46 A1-B2-C47 A1-B2-C48
AI-B2-C49 A1-B2-C50 A1-B2-C51 A1-B2-C52 A1-B2-C53 A1-B2-C54
A1-B2-C55 A1-B2-C56 A1-B2-C57 A1-B2-C58 A1-B2-C59 A1-B2-C60
A1-B2-C61 A1-B2-C62 A1-B2-C63 A1-B2-C64 A1-B2-C65 A1-B2-C66
A1-B2-C67 AI-B2-C68 A1-B2-C69 A1-B2-C70 A1-B2-C71 A1-B2-C72
A1-B2-C73 A1-B2-C74 A1-B2-C75 A1-B2-C76 A1-B2-C77 AI-B2-C78
A1-B2-C79 A1-B2-C80 A1-B2-C81 A1-B2-C82 A1-B2-C83 A1-B2-C84
A1-B2-C85 A1-B2-C86 A1-B2-C87 A1-B2-C88 A1-B2-C89 A1-B2-C90
A1-B2-C91 A1-B2-C92 A1-B2-C93 A1-B2-C94 A1-B2-C95 A1-B2-C96
A1-B2-C97 A1-B2-C98 A1-B2-C99 A1-B2-C100 A1-B2-C101 A1-B2-C102
A1-B2-C103 A1-B2-C104 A1-B2-C105 A1-B2-C106 A1-B2-C107 A1-B2-C108
A1-B2-C109 A1-B2-C110 A1-B2-C111 A1-B2-C112 A1-B2-C113 A1-B2-C114
A1-B2-C115 A1-B2-C116 A1-B2-C117 A1-B2-C118 A1-B2-C119 A1-B2-C120
A1-B2-C121 A1-B2-C122 A1-B2-C123 A1-B2-C124 A1-B2-C125 A1-B2-C126
AI-B2-C127 A1-B2-C128 A1-B2-C129 A1-B2-CI30 A1-B2-C131 A1-B2-C132
A1-B2-C133 A1-B2-C134 A1-B2-C135 A1-B2-C136 A1-B2-CI37 A1-B2-C138
A1-B2-C139 AI-B2-C140 BLANK BLANK BLANK BLANK
A1-B3-C1 A1-B3-C2 A1-B3-C3 A1-B3-C4 A1-B3-C5 A1-B3-C6
A1-B3-C7 A1-B3-C8 A1-B3-C9 A1-B3-CI0 Al-B3-Cn A1-B3-C12
A1-B3-C13 A1-B3-C14 A1-B3-C15 A1-B3-C16 A1-B3-C17 A1-B3-C18
A1-B3-C19 A1-B3-C20 A1-B3-C21 A1-B3-C22 A1-B3-C23 AI-B3-C24
A1-B3-C25 A1-B3-C26 A1-B3-C27 A1-B3-C28 A1-B3-C29 A1-B3-C30
A1-B3-C31 A1-B3-C32 A1-B3-C33 A1-B3-C34 A1-B3-C35 A1-B3-C36
A1-B3-C37 A1-B3-C38 A1-B3-C39 A1-B3-C40 A1-B3-C41 A1-B3-C42


A1-B3-C49 A1-B3-C50 A1-B3-C51 A1-B3-C52 A1-B3-C53 A1-B3-C54
AI-B3-C55 A1-B3-C56 A1-B3-C57 A1-B3-C58 A1-B3-C59 AKB3-C60
A1-B3-C61 A1-B3-C62 A1-B3-C63 A1-B3-C64 A1-B3-C65 ANB3-C66
AI-B3-C67 A1-B3-C68 A1-B3-C69 A1-B3-C70 A1-B3-C71 A1-B3-C72
A1-B3-C73 A1-B3-C74 A1-B3-C75 A1-B3-C76 A1-B3-C77 A1 -B3'C78
A1-B3-C79 A1-B3-C80 A1-B3'C81 A1-B3-C82 A1-B3-C83 A1-B3'C84
A1-B3-C85 A1-B3-C86 A1-B3-C87 A1-B3-C88 A1-B3-C89 A1-B3-C90
A1-B3-C91 A1-B3-C92 A1-B3-C93 A1-B3-C94 A1-B3-C95 A1-B3-C96
AI-B3-C97 A1-B3-C98 A1-B3-C99 AI-B3-C100 A1-B3-C101 AI-B3-C102
A1-B3-C103 A1-B3-C104 A1-B3-C105 A1-B3-C106 A1-B3-C107 A1-B3-C108
ANB3-C109 A1-B3-C110 Al-B3-Cni A1-B3-C112 A1-B3-CI13 A1-B3-C114
A1-B3-C115 A1-B3-C116 A1-B3-C117 A1-B3-CI18 AI-B3-C119 A1-B3-C120
A1-B3-C121 A1-B3-C122 A1-B3-C123 A1-B3-C124 A1-B3-C125 A1-B3-CI26
A1-B3-C127 AI-B3-C128 A1-B3-CI29 A1-B3-C130 A1-B3-C131 A1-B3-C132
A1-B3-C133 A1-B3-C134 A1-B3-C135 AI-B3-C136 A1-B3-C137 A1-B3-C138
AI-B3-C139 A1-B3-C140 BLANK BLANK BLANK BLANK
A1-B4-C1 A1-B4-C2 A1-B4-C3 A1-B4-C4 A1-B4-C5 A1-B4-C6
A1-B4-C7 A1-B4-C8 A1-B4-C9 A1-B4-C10 A1-B4-C11 A1-B4-C12
A1-B4-C13 A1-B4-C14 A1-B4-C15 A1-B4-C16 A1-B4-C17 A1-B4-C18
A1-B4-C19 A1-B4-C20 A1-B4-C21 A1-B4-C22 A1-B4-C23 A1 'B4-C24
A1-B4-C25 A1-B4-C26 A1-B4-C27 A1-B4-C28 A1-B4-C29 A1-B4-C30
A1-B4-C31 A1-B4-C32 A1-B4-C33 A1-B4-C34 A1-B4-C35 A1-B4-C36
A1-B4-C37 A1-B4-C3 8 A1-B4-C39 A1-B4-C40 A1-B4-C41 A1 -B4-C42
AI-B4-C43 A1 '-B4-C44 A1-B4-C45 A1-B4-C46 A1-B4-C47 A1-B4-C48
A1-B4-C49 A1-B4-C50 A1 -B4-C51 A1-B4-C52 A1-B4-C53 A1-B4-C54
A1-B4-C55 A1-B4'C56 A1-B4-C57 A1-B4-C58 A1-B4-C59 A1-B4-C60
A1-B4-C61 A1-B4-C62 A1-B4-C63 A1-B4-C64 A1-B4-C65 A1-B4-C66
A1-B4-C67 A1-B4-C68 A1-B4-C69 A1-B4-C70 A1-B4-C71 A1-B4-C72
A1-B4-C73 A1-B4-C74 A1-B4-C75 A1-B4-C76 A1-B4-C77 A1-B4-C78
A1-B4-C79 A1-B4-C80 A1-B4-C81 AI-B4-C82 A1-B4-C83 A1-B4-C84
A1-B4-C85 A1-B4-C86 A1-B4-C87 A1-B4-C88 A1-B4-C89 A1-B4-C90
A1-B4-C91 A1-B4-C92 A1-B4-C93 A1-B4-C94 A1-B4-C95 A1-B4-C96
A1-B4-C97 A1-B4-C98 A1-B4-C99 A1-B4-C100 A1-B4-C101 A1-B4-C102
AI-B4-C103 A1-B4-C104 A1-B4-C105 A1-B4-C106 A1-B4-C107 A1-B4-C108
A1-B4-C109 A1-B4-C110 A1-B4'C111 A1-B4-C112 A1-B4-C113 A1-B4-C114
A1-B4-C115 A1-B4-C116 A1-B4-C117 A1-B4-C118 A1-B4-C119 A1-B4-C120
A1-B4-C121 A1-B4-C122 A1-B4-C123 A1-B4-C124 ANB4-C125 A1-B4-C126

A1-B4-C127 A1-B4-C128 A1-B4-C129 A1-B4-C130 A1-B4-C131 A1-B4-C132
A1-B4-C133 A1-B4-CI34 A1-B4-C135 A1-B4-C136 A1-B4-C137 A1-B4-C138
A1-B4-C139 A1-B4-C140 BLANK BLANK BLANK BLANK
A1-B5-C1 A1-B5-C2 A1-B5-C3 A1-B5-C4 A1-B5-C5 A1-B5-C6
A1-B5-C7 A1-B5-C8 A1-B5-C9 A1-B5-C10 A1-B5-C11 A1-B5-C12
A1-B5-C13 A1-B5-C14 A1-B5-C15 A1-B5-C16 A1-B5-C17 A1-B5-C18
A1-B5-C19 A1-B5-C20 A1-B5-C21 A1-B5-C22 A1-B5-C23 A1-B5-C24
AI-B5-C25 A1-B5-C26 A1-B5-C27 A1-B5-C28 A1-B5-C29 A1-B5-C30
A1-B5-C31 A1-B5-C32 A1-B5-C33 A1-B5-C34 A1-B5-C35 A1-B5-C36
A1-B5-C37 AI-B5-C38 A1-B5.C39 A1-B5-C40 A1-B5-C41 A1-B5-C42
A1-B5-C43 A1-B5-C44 A1-B5-C45 A1-B5-C46 A1-B5-C47 A1-B5-C48
A1-B5-C49 A1-B5-C50 A1-B5-C51 A1-B5-C52 A1-B5-C53 A1-B5-C54
A1-B5-C55 A1-B5-C56 A1-B5.C57 A1-B5-C58 A1-B5-C59 A1-B5-C60
A1-B5-C61 A1-B5-C62 A1-B5-C63 A1-B5-C64 A1-B5-C65 A1-B5-C66
A1-B5-C67 A1-B5-C68 A1-B5-C69 AI-B5-C70 A1-B5-C71 A1-B5-C72
A1-B5-C73 A1-B5-C74 A1-B5-C75 A1-B5-C76 A1-B5-C77 A1-B5-C78
A1-B5-C79 A1-B5-C80 A1-B5-C8I A1-B5-C82 A1-B5-C83 A1-B5-C84
AI-B5-C85 A1-B5-C86 AI-B5-C87 A1-B5-C88 A1-B5-C89 A1-B5-C90
A1-B5-C91 A1-B5-C92 A1-B5-C93 A1-B5-C94 A1-B5-C95 A1-B5-C96
A1-B5-C97 A1-B5-C98 AI-B5-C99 A1-B5-C100 A1-B5-CI01 A1-B5-C102
A1-B5-C103 A1-B5-C104 A1-B5-C105 A1-B5-C106 A1-B5-C107 A1-B5-C108
A1-B5-C109 A1-B5-C110 A1-B5-C111 A1-B5-C112 Al-B5-Cn3 A1-B5-C114
A1-B5-C115 AI-B5-C116 A1-B5-C117 A1-B5-C118 A1-B5-C1I9 AI-B5-C120
A1-B5-C121 ANB5-C122 A1-B5-C123 A1-B5-CI24 A1-B5-C125 A1-B5-C126
A1-B5-C127 A1-B5-C128 A1-B5-C129 A1-B5-C130 A1-B5-C131 A1-B5-C132
A1-B5-C133 A1-B5-C134 A1-B5-C135 A1-B5-C136 A1-B5-C137 A1-B5-C138
A1-B5-C139 A1-B5-C140 BLANK BLANK BLANK BLANK
A1-B6-C1 A1-B6-C2 AI-B6-C3 A1-B6-C4 A1-B6-C5 A1-B6-C6
A1-B6-C7 A1-B6-C8 A1-B6-C9 A1-B6-C10 A1-B6-C11 A1-B6-C12
A1-B6-C13 A1-B6-C14 A1-B6-C15 A1-B6-C16 A1-B6-C17 A1-B6-C18
A1-B6-C19 A1-B6-C20 A1-B6-C21 A1-B6-C22 A1-B6-C23 A1-B6-C24
A1-B6-C25 A1-B6-C26 A1-B6-C27 A1-B6-C28 A1-B6-C29 A1-B6-C30
A1-B6-C31 A1-B6-C32 A1-B6-C33 A1-B6-C34 A1-B6-C35 A1-B6-C36
A1-B6-C37 A1-B6-C38 Al -B6-C39 Al -B6-C40 Al -B6-C41 AI-B6-C42
A1-B6-C43 A1-B6-C44 A1-B6-C45 A1-B6-C46 A1-B6-C47 A1-B6-C48
A1-B6-C49 A1-B6-C50 A1-B6-C51 A1-B6-C52 A1-B6-C53 AI-B6-C54
A1-B6-C55 A1-B6-C56 A1-B6-C57 A1 -B6-C58 A1-B6-C59 A1-B6-C60

A1-B6-C61 A1-B6-C62 A1-B6-C63 A1-B6-C64 A1-B6-C65 A1-B6-C66
A1-B6-C67 A1-B6-C68 A1-B6-C69 A1-B6-C70 A1-B6-C71 A1-B6-C72
A1-B6-C73 A1-B6-C74 A1-B6-C75 A1-B6-C76 A1-B6-C77 A1-B6-C78
A1-B6-C79 A1-B6-C80 AI-B6-C81 A1-B6-C82 A1-B6-C83 A1-B6-C84
A1-B6-C85 A1-B6-C86 A1-B6-C87 A1-B6-C88 A1-B6-C89 A1-B6-C90
A1-B6-C9] A1-B6-C92 A1-B6-C93 A1-B6-C94 A1-B6-C95 A1-B6-C96
A1-B6-C97 A1-B6-C98 A1-B6-C99 A1-B6-C100 A1-B6-C101 A1-B6-C102
A1-B6-C103 A1-B6-C104 A1-B6-C105 AI-B6-CI06 A1-B6-C107 A1-B6-C108
A1-B6-C109 A1-B6-C110 A1-B6-C111 A1-B6-C112 A1-B6-C113 A1-B6-C114
A1-B6-C115 A1-B6-C116 A1-B6-C117 A1-B6-C118 A1-B6-C119 A1-B6-C120
A1-B6-C121 A1-B6-C122 AI-B6-C123 A1-B6-C124 A1-B6-C125 A1-B6-C126
A1-B6-C127 A1-B6-C128 A1-B6-C129 A1-B6-C130 A1-B6-C131 A1-B6-C132
A1-B6-C133 A1-B6-C134 A1-B6-C135 A1-B6-C136 A1-B6-C137 A1-B6-C138
A1-B6-CI39 A1-B6-C140 BLANK BLANK BLANK BLANK
A1-B7-C1 A1-B7-C2 A1-B7-C3 A1-B7-C4 AI-B7-C5 A1-B7-C6
A1-B7-C7 A1-B7-C8 A1-B7-C9 A1-B7-C10 A1-B7-C11 A1-B7-C12
AI-B7-C13 A1-B7-C14 A1-B7-C15 A1-B7-C16 A1-B7-C17 A1-B7-C18
A1-B7-C19 A1-B7-C20 A1-B7-C21 AI-B7-C22 A1-B7-C23 A1-B7-C24
A1-B7-C25 A1-B7-C26 A1-B7-C27 A1-B7-C28 A1-B7-C29 A1-B7-C30
A1-B7-C31 A1-B7-C32 A1-B7-C33 AI-B7-C34 A1-B7-C35 A1-B7-C36
A1-B7-C37 A1-B7-C38 AI-B7-C39 A1-B7-C40 A1-B7-C41 A]-B7-C42
A1-B7-C43 A1-B7-C44 A1-B7-C45 A1-B7-C46 A1-B7-C47 AI-B7-C48
AI-B7-C49 A1-B7-C50 A1-B7-C51 A1-B7-C52 A1-B7-C53 A1-B7-C54
A1-B7-C55 AI-B7-C56 A1-B7-C57 A1-B7-C58 A1-B7-C59 A1-B7-C60
A1-B7-C61 A1-B7-C62 A1-B7-C63 A1-B7-C64 AI-B7-C65 A1-B7-C66
A1-B7-C67 A1-B7-C68 A1-B7-C69 A1-B7-C70 A1-B7-C71 A1-B7-C72
A1-B7-C73 A1-B7-C74 A1-B7-C75 A1-B7-C76 A1-B7-C77 A1-B7-C78
A1-B7-C79 A1-B7-C80 A1-B7-C8I AI-B7-C82 A1-B7-C83 A1-B7-C84
A1-B7-C85 A1-B7-C86 A1-B7-C87 A1-B7-C88 A1-B7-C89 A1-B7-C90
A1-B7-C91 A1-B7-C92 A1-B7-C93 A1-B7-C94 A1-B7-C95 A1-B7-C96
A1-B7-C97 A1-B7-C98 A1-B7-C99 A1-B7-C100 A1-B7-C101 A1-B7-C102
A1-B7-C103 A1-B7-C104 A1-B7-C105 A1-B7-C106 A1-B7-C107 A1-B7-C108
A1-B7-C109 A1-B7-C110 A1-B7-C111 A1-B7-C112 A1-B7-C113 A1-B7-C114
A1-B7-CI15 A1-B7-C116 A1-B7-C117 Al-B7-Cn8 A]-B7-C])9 A)-B7-C120
A1-B7-C121 A1-B7-C122 A1-B7-C123 A1-B7-C124 AI-B7-C125 A1-B7-C126
A1-B7-C127 A1-B7-C128 A1-B7-C129 A1-B7-C130 A1-B7-C131 A1-B7-C132
AI-B7-C133 A1-B7-C134 A1-B7-C135 A1-B7-C136 A1-B7-C137 A1-B7-C138

A1-B7-C139 A1-B7-C140 BLANK BLANK BLANK BLANK
A1-B8-C1 A1-B8-C2 A1-B8-C3 A1-B8-C4 A1-B8-C5 AI-B8-C6
A1-B8-C7 A1-B8-C8 A1-B8-C9 A1-B8-CI0 A1-B8-C11 AI-B8-C12
A1-B8-C13 A1-B8-C14 AI-B8-C15 A1-B8-CI6 A1-B8-C17 A1-B8-C18
A1-B8-C19 A1-B8-C20 AI-B8-C2I A1-B8-C22 A1-B8-C23 A1-B8-C24
A1-B8-C25 AI-B8-C26 AI-B8-C27 A1-B8-C28 A1-B8-C29 A1-B8-C30
A1-B8-C31 A1-B8-C32 A1-B8-C33 A1-B8-C34 A1-B8-C35 AI-B8-C36
AI-B8-C37 AI-B8-C38 AI-B8-C39 A1-B8-C40 A1-B8-C41 A1-B8-C42
A1-B8-C43 A1-B8-C44 A1-B8-C45 A1-B8-C46 A1-B8-C47 A1-B8-C48
A1-B8-C49 A1-B8-C50 A1-B8-C51 A1-B8-C52 A1-B8-C53 A1-B8-C54
AI-B8-C55 A1-B8-C56 A1-B8-C57 A1-B8-C58 A1-B8-C59 A1-B8-C60
A1-B8-C61 A1-B8-C62 A1-B8-C63 A1-B8-C64 A1-B8-C65 A1-B8-C66
A1-B8-C67 A1-B8-C68 A1-B8-C69 A1-B8-C70 A1-B8-C71 A1-B8-C72
A1-B8-C73 A1-B8-C74 A1-B8-C75 A1-B8-C76 A1-B8-C77 A1-B8-C78
A1-B8-C79 A1-B8-C80 A1-B8-C81 A1-B8-C82 A1-B8-C83 A1-B8-C84
A1-B8-C85 A1-B8-C86 A1-B8-C87 A1-B8-C88 A1-B8-C89 A1-B8-C90
A1-B8-C91 A1-B8-C92 A1-B8-C93 A1-B8-C94 A1-B8-C95 A1-B8-C96
A1-B8-C97 A1-B8-C98 A1-B8-C99 A1-B8-C100 A1-B8-C10I A1-B8-C102
A1-B8-C103 A1-B8-C104 A1-B8-C105 A1-B8-C106 A1-B8-C107 A1-B8-C108
A1-B8-C109 A1-B8-C110 Al-BS-CllI A1-B8-CII2 A1-B8-C113 A1-B8-C114
A1-B8-C115 A1-B8-C116 A1-B8-C117 A1-B8-CI18 A1-B8-C119 A1-B8-C120
A1-B8-C121 A1-B8-C122 A1-B8-C123 A1-B8-C124 A1-B8-C125 A1-B8-C126
A1-B8-C127 A1-B8-C128 A1-B8-C129 A1-B8-C130 A1-B8-C131 A1-B8-C132
A1-B8-C133 A1-B8-C134 A1-B8-C135 A1-B8-C136 A1-B8-C137 A1-B8-C138
A1-B8-CI39 Al-B8-Ci40 BLANK BLANK BLANK BLANK
AI-B9-C1 AI-B9-C2 A1-B9-C3 A1-B9-C4 A1-B9-C5 A1-B9-C6
AI-B9-C7 A1-B9-C8 A1-B9-C9 A1-B9-C10 A1-B9-C11 A1-B9-C12
A1-B9-C13 A1-B9-C14 A1-B9-CI5 A1-B9-C16 A1-B9-C17 A1-B9-C18
AI-B9-C19 A1-B9-C20 A1-B9-C21 A1-B9-C22 A1-B9-C23 A1-B9-C24
A1-B9-C25 A1-B9-C26 A1-B9-C27 A1-B9-C28 A1-B9-C29 A1-B9-C30
A1-B9.C3I A1-B9-C32 A1-B9-C33 A1-B9-C34 A1-B9-C35 A1-B9-C36
A1-B9-C37 A1-B9-C38 A1-B9-C39 A1-B9-C40 A1-B9-C41 A1-B9-C42
A1-B9-C43 A1-B9-C44 A1-B9-C45 A1-B9-C46 A1-B9-C47 A1-B9-C48
A1-B9-C49 A1-B9-C50 A1-B9-C51 A1-B9-C52 A1-B9-C53 A1-B9-C54
A1-B9-C55 A1-B9-C56 A1-B9-C57 A1-B9-C58 A1-B9-C59 A1-B9-C60
A1-B9-C61 A1-B9-C62 A1-B9-C63 A1-B9-C64 A1-B9-C65 A1-B9-C66
A1-B9-C67 A1-B9-C68 A1-B9-C69 A1-B9-C70 AI-B9-C71 A1-B9-C72

AI-B9-C73 A1-B9-C74 A1-B9-C75 A1-B9-C76 A1-B9-C77 A1-B9-C78
A1-B9-C79 A1 -B9-C80 A1-B9-C81 A1-B9-C82 A1-B9-C83 A1-B9-C84
A1-B9-C85 A1-B9-C86 A1-B9-C87 AI-B9-C88 A1-B9-C89 A1-B9-C90
A1-B9-C91 A1-B9-C92 A1-B9-C93 A1-B9-C94 A1-B9-C95 A1-B9-C96
A1-B9-C97 A1-B9-C98 A1-B9-C99 A1-B9-C100 A1-B9-C101 A1-B9-C102
A1-B9-C103 A1-B9-C104 A1-B9-C105 A1-B9-C106 AI-B9-C107 A1-B9-C108
A1-B9-C109 A1-B9-C110 AI-B9-C11I A1-B9-C112 A1-B9-C113 AI-B9-C114
A1-B9-C115 A1-B9-CI16 A1-B9-C117 A1-B9-C118 A1-B9-C119 A1-B9-C120
A1-B9-C121 A ] -B9-C122 A1-B9-C123 A1-B9-C124 A1-B9-C125 A1-B9-C126
A1-B9-C127 AI-B9-C128 A1-B9-C129 A1-B9-C130 A1-B9-C131 AI-B9-C132
A1-B9-C133 A1-B9-C134 A1-B9-C135 A1-B9'C136 A1-B9-C137 A1-B9-C138
A1-B9-C139 A1-B9-C140 BLANK BLANK BLANK BLANK
Al-BlO-Cl A1-B10-C2 A1-B10-C3 A1-B10-C4 A1-B10-C5 A1-B10-C6
A1-B10-C7 AI-B10-C8 A1-B10-C9 AI-BIO-CIO Al-BlO-Cll A1-B10-C12
A1-B10-C13 A1-B10-C14 A1-B10-C15 A1-B10-CI6 A1-B10-C17 A1-B10-C18
A1-B10-C19 A1-B10-C20 A1-B10-C21 A1-B10-C22 A1-B10-C23 A1-B10-C24
AI -B10-C25 A1 -B10-C26 A1 -B10-C27 A1 -B10-C28 A1 -B10-C29 AI -B10-C30
A1-B10-C3I A1-B10-C32 A1-B10-C33 A1-B10-C34 A1-B10-C35 AI-B10-C36
A1-B10-C37 A1-B10-C38 A1-B10'C39 AI-B10-C40 AI-B10-C41 A1-B10-C42
AI -B10-C43 A1 -B10-C44 A1 -B10-C45 A1 -B10-C46 A1 -B10'C47 A1 -B10-C48
AI-B10-C49 A1-B10-C50 A1-B10-C51 A1-B10-C52 A1-B10-C53 A1-B10-C54
A1-B10-C55 A1-B10-C56 A1-B10-C57 A1-B10-C58 A1-B10-C59 A1-B10-C60
AI -B10-C61 A1 -B10-C62 AI -B10-C63 A1 -B10-C64 A1 -B10-C65 A1 -B10-C66
A1-BI0-C67 A1-B10-C68 A1-B10-C69 A1-B10-C70 A1-B10-C71 A1-B10-C72
A1 -B10-C73 A1 -B10-C74 A1 -B10-C75 AI -B10-C76 A1 -B10-C77 A1 -B10-C78
A1-B10-C79 A1-B10-C80 A1-B10-C81 A1-B10-C82 A1-B10-C83 A1-B10-C84
A1-B10~C85 A1-B10-C86 A1-B10-C87 A1-B10-C88 A1-B10-C89 A1-B10-C90
A1-B10'C91 A1-B10-C92 A1-B10-C93 A1-B10-C94 A1-B10-C95 A1-B10-C96
A1-B10-C97 A1-B10-C98 A1-B10-C99 Al-BIO-ClOO Al-BlO-ClOl AI-B10-C102
Al-B10-CI03 A1-B10-C104 A1-B10-C105 A1-B10-C106 A1-B10-C107 A1-B10-C108
A1-B10-CI09 AI-BlO-CllO Al-BlO-Clll A1-B10-C112 AI-BIO-CIH A1-B10-C1I4
A1-B10-C115 A1-B10-C116 A1-B10-C117 A1-B10-C118 A1-B10-C119 A1'B10-C120
A1-B10-C121 A1-B10-C122 A1-B10-C123 A1-B10-C124 A1-B10-C125 A1-B10-C126
A1-B10-C127 AI-B10-C128 A1-B10-C129 A1-B10-C130 A1-B10-C131 A1'B10-C132
A1-BI0-C133 A1-B10-C134 A1-B10-C135 A1-B10-C136 A1-B10-C137 A1-B10-C138
A1 -B10-Cl39 AI -B10-C140 BLANK BLANK BLANK BLANK
Al-Bll-Cl A1-BI1-C2 A1-B11-C3 A1-B11-C4 A1-B11-C5 A1-B11-C6

A1-B11-C7 Al-BU-CS A1-B11-C9 Al-Bll-ClO Al-Bll-Cll A1-B11-C12
Al-B!l-C13 A1-B11-C14 A1-B11-C15 A1-B11-C16 A1-BI1-C17 A1-BU-C18
A1-B11-C19 A1-B11-C20 A1-B11-C21 Al-Bn-C22 A1-B11-C23 A1-B11-C24
A1-B11-C25 A1-B11-C26 A1-B11-C27 A1-B11-C28 A1-B11-C29 A1-B11-C30
A1-B11-C31 A1-BII-C32 A1-B11-C33 AKB11-C34 A1-B11-C35 A1-B11-C36
AI-B1NC37 AKB11-C38 A1-B11-C39 A1-B11-C40 A1-B11-C41 A1-B11-C42
A1-B11-C43 Al-Bl 1-C44 Al-Bl 1-C45 Al-Bl 1-C46 Al-Bl 1-C47 Al-Bl 1-C48
A1-B11-C49 Al-Bl 1-C50 Al-Bl 1-C51 A1-B11-C52 Al-Bl 1-C53 Al-Bl 1-C54
Al-Bl 1-C55 Al-Bll-C56 Al-Bl 1-C57 Al-Bl 1-C58 AUB11-C59 AI-B11-C60
A1-B11-C61 Al-Bl 1-C62 Al-Bl 1-C63 Al-Bl 1-C64 Al-Bl 1-C65 Al-Bl 1-C66
Al-Bl 1-C67 Al-Bl 1-C68 Al-Bl 1-C69 Al-Bl 1-C70 Al-Bl 1-C71 Al-Bl 1-C72
Al-Bl 1-C73 Al-Bl 1-C74 Al-Bl 1-C75 Al-Bl 1-C76 Al-Bl 1-C77 A1-B11-C78
A1-B11-C79 Al-Bl 1-C80 Al-Bl 1-C81 Al-Bl 1-C82 Al-Bl 1-C83 Al-Bl 1-084
Al-Bll-C85 Al-Bl 1-C86 Al-Bl 1-C87 Al-Bl 1-C88 Al-Bl 1-C89 Al-Bl 1-C90
Al-Bl 1-C91 Al-Bl 1-C92 Al-Bl 1-C93 Al-Bl 1-C94 Al-Bl 1-C95 Al-Bl 1-C96
A1-B11-C97 Al-Bl 1-C98 Al-Bl 1-C99 Al-Bl 1-ClOO Al-Bl l-Cl01 Al-Bl 1-C102
Al-Bl 1-C103 Al-Bl 1-C104 Al-Bl I-C105 Al-Bl 1-C106 Al-Bl 1-C107 Al-Bl 1-C108
Al-Bl 1-C109 Al-Bl 1-Cl 10 Al-Bll-Clll Al-Bl 1-Cl 12 Al-Bl 1-Cl 13 Al-Bl 1-Cl 14
Al-Bl 1-Cl 15 Al-Bl l-Cl 16 Al-Bl 1-Cl 17 Al-Bl 1-Cl 18 ANB11-C119 Al-Bl 1-Cl20
Al-Bl 1-C121 Al-Bl 1-C122 Al-Bl 1-C123 Al-Bl 1-C124 Al-Bl 1-Cl 25 Al-Bl 1-C126
Al-Bl 1-C127 Al-Bl l-Cl28 Al-Bl 1-C129 Al-Bl 1-C130 Al-Bl 1-Cl31 Al-Bl 1-Cl32
Al-Bl 1-C133 Al-Bl 1-C134 Al-Bl 1-C135 Al-Bl 1-C136 Al-Bll-C137 Al-Bl 1-C138
A1-B11-C139 Al-Bl 1-C140 BLANK BLANK BLANK BLANK
A1-B12-C1 AI-B12-C2 Al-Bl 2-C3 Al-Bl 2-C4 Al-Bl 2-C5 AI-B12-C6
A1-B12-C7 A1-B12-C8 A1-B12-C9 AI-B12-C10 A1-B12-CI1 A1-B12-C12
Al-Bl 2-C13 A1-B12-C14 AI-B12-C15 A1-B12-C16 AI-B12-C17 AKB12-C18
A1-B12-C19 A1-B12-C20 A1-B12-C21 A1-B12-C22 A1-B12-C23 A1-B12-C24
A1-B12-C25 A1-B12-C26 A1-B12-C27 AI-B12-C28 Al-Bl 2-C29 A1-B12-C30
A1-B12-C31 Al-Bl 2-C32 Al-Bl 2-C33 A1-B12-C34 AI-B12-C35 A1-B12-C36
A1-B12-C37 A1-B12-C38 Al-Bl 2-C39 A1-B12-C40 AI-B12-C41 Al-Bl 2-C42
A1-B12-C43 A1-B12-C44 AI-B12-C45 AI-B12-C46 Al-Bl 2-C47 A1-B12-C48
A1-B12-C49 A1-B12-C50 A1-B12-C51 A1-B12-C52 Al-Bl 2-C53 AKB12-C54
A1-B12-C55 Al-Bl 2-C56 A1-B12-C57 A1-B12-C58 Al-Bl 2-C59 A1-B12-C60
Al-Bl 2-C61 Al-Bl 2-C62 Al-Bl 2-C63 Al-Bl 2-C64 Al-Bl 2-C65 Al-Bl 2-C66
Al-Bl 2-C67 Al-Bl 2-C68 Al-Bl 2-C69 Al-Bl 2-C70 Al-Bl 2-C71 Al-Bl 2-C72
A1-B12-C73 A1-B12-C74 A1-B12-C75 A1-B12-C76 AI-B12-C77 A1-B12-C78
AI-BI2-C79 A1-B12-C80 A1-B12-C81 A1-B12-C82 A1-B12-C83 A1-B12-C84

A1-B12-C85 A1-B12-C86 A1-B12-C87 A1-B12-C88 A1-B12-C89 A1-B12-C90
A1 -B12-C91 A1 -B12-C92 A1 -B12-C93 A1 -B12-C94 A1 -B12-C95 AI -B12-C96
A1-B12-C97 A1-B12-C98 A1-B12-C99 A1-B12-C100 A1-B12-C101 A1-B12-C102
A1-B12-C103 AI-B12-C104 A1-B12-C105 A1-B12-C106 AI-B12-C107 A1-B12-CI08
A1-BI2-C109 A-B12-C110 A1-B12-CI11 A1-B12-C112 A1-B12-C113 A1-B12-C114
A1-B12-C115 A1-B12-C116 Al-B12-Cn7 A1-B12-CI18 Al-B12-Cn9 A1-B12-C120
A1-B12-C121 A1-B12-C122 A1-B12-C123 AI-B12-C124 A1-B12-C125 A1-B12-C126
A1-B12-C127 A1-B12-C128 A1-B12-C129 A1-B12-C130 A1-B12-C131 A1-B12-C132
A1-B12-CI33 A1-B12-C134 A1-B12-C135 A1-B12-C136 A1-B12-C137 A1-B12-C138
A1-B12-CI39 A1-B12-C140 BLANK BLANK BLANK BLANK
A1-B13-C1 A1-B13-C2 A1-B13-C3 A1-B13-C4 A1-B13-C5 A1-B13-C6
A1-B13-C7 A1-B13-C8 AI-B13-C9 A1-B13-C10 A1-B13-C11 A1-BI3-C12
A1-B13-C13 A1-B13-C14 A1-B13-C15 A1-B13-C16 A1-B13-C17 A1-B13-CI8
A1-B13-C19 A1-B13-C20 A1-B13-C21 A1-B13-C22 A1-B13-C23 A1-B13-C24
A1-B13-C25 A1-B13-C26 A1-B13-C27 A1-B13-C28 A1-B13-C29 A1-B13-C30
A1-B13-C31 A1-B13-C32 A1-B13-C33 AI-B13-C34 A1-B13-C35 A1-B13-C36
A1-B13-C37 A1-B13-C38 A1-B13-C39 A1-B13-C40 A1-B13-C41 ANB13-C42
A1-B13-C43 A1-B13-C44 AI-B13-C45 A1-B13-C46 A1-B13-C47 A1-B13-C48
A1-B13-C49 A1-B13-C50 A1-B13-C51 A1-B13-C52 A1-B13-C53 A1-B13-C54
A1-B13-C55 A1-B13-C56 A1-B13-C57 A1-B13-C58 A1-B13-C59 A1-B13-C60
A1-B13-C61 A1-B13-C62 A1-B13-C63 A1-B13-C64 AI-B13-C65 A1-B13-C66
A1-B13-C67 A1-B13-C68 A1-B13-C69 A1-B13-C70 A1-B13-C71 A1-B13-C72
A1-B13-C73 A1-B13-C74 A1-B13-C75 A1-B13-C76 A1-B13-C77 A1-B13-C78
A1-B13-C79 A1-B13-C80 A1-B13-C81 A1-B13-C82 A1-B13-C83 A1.B13-C84
A1-B13-C85 A1-B13-C86 A1-B13-C87 A1-B13-C88 A1-B13-C89 A1-B13-C90
A1-B13-C91 A1-BI3-C92 A1-B13-C93 A1-B13-C94 A1-B13-C95 A1-B13-C96
A1-B13-C97 A1-BI3-C98 A1-B13-C99 A1-B13-C100 A1-B13-C101 A1.B13-C102
A1-B13-C103 A1-B13-C104 A1-B13-C105 A1-B13-C106 A1-BI3-C107 A1-B13-CI08
A1-B13-C109 A1-B13-C110 A1-B13-C111 A1-BI3-C112 A1-B13-C113 AUB13-C114
A1-B13-C115 A1-B13-C116 A1-B13-C117 A1-B13-C118 Al-B13-Cn9 A1-B13-C120
A1-B13-C121 A1-B13-C122 A1-B13-C123 A1-B13-C124 A1-B13-C125 A1-B13-C126
A1-B13-C127 A1-B13-CI28 A1-B13-C129 A1-B13-C130 A1-BI3-C131 A1-B13-C132
A1-B13-C133 A1-B13-C134 A1-B13-C135 A1-B13-C136 A1-B13-C137 A1-B13-C138
A1-B13-C139 A1-B13-C140 BLANK BLANK BLANK BLANK
A2-B1 -C1 A2-B1 -C2 A2-B1 -C3 A2-B1 -C4 A2-B1 -C5 A2-B1 -C6
A2-B 1 -C7 A2-B1 -C8 A2-B1 -C9 A2-B1 -C10 A2-B1 -C11 A2-B1 -C12
A2.B1-C13 A2-BKC14 A2-BNC15 A2-B1-C16 A2-B1-C17 A2-B1-C18

A2-B1-C19 A2-B1-C20 A2-B1-C21 A2-B1-C22 A2-B1-C23 A2-B1-C24
A2-B1-C25 A2-B1-C26 A2-B1-C27 A2-B1-C28 A2-BI-C29 A2-B1-C30
A2-B1-C31 A2-B1-C32 A2-B1-C33 A2-B1-C34 A2-B1-C35 A2-B1-C36
A2-B1-C37 A2-B1-C38 A2-B1-C39 A2-B1-C40 A2-B1-C41 A2-B1-C42
A2-B1-C43 A2-B1-C44 A2-B1-C45 A2-B1-C46 A2-B1-C47 A2-B1-C48
A2-B1-C49 A2-B1-C50 A2-B1-C51 A2-B1-C52 A2-B1-C53 A2-B1-C54
A2-B1-C55 A2-B1-C56 A2-B1-C57 A2-B1-C58 A2-B1-C59 A2-B1-C60
A2-B1-C61 A2-B1-C62 A2-B1-C63 A2-B1-C64 A2-B1-C65 A2-B1-C66
A2-B1-C67 A2-B1-C68 A2-B1-C69 A2-B1-C70 A2-B1-C71 A2-B1-C72
A2-B1-C73 A2-B1-C74 A2-B1-C75 A2-B1-C76 A2-B1-C77 A2-B1-C78
A2-B1-C79 A2-B1-C80 A2-B1-C81 A2-B1-C82 A2-B1-C83 A2-B1-C84
A2-B1-C85 A2-B1-C86 A2-B1-C87 A2-B1-C88 A2-B1-C89 A2-B1-C90
A2-B1-C91 A2-B1-C92 A2-B1-C93 A2-B1-C94 A2-B1-C95 A2-B1-C96
A2-BI-C97 A2-B1-C98 A2-B1-C99 A2-B1-C100 A2-B1-C101 A2-B1-C102
A2-B1-C103 A2-B1-C104 A2-B1-C105 A2-B1-C106 A2-B1-C107 A2-B1-C108
A2-B1-C109 A2-Bl-Cn0 A2-Bl-Cni A2-B1-C112 A2-B1-C113 A2-B1-C114
A2-B1-C1I5 A2-B1-C116 A2-B1-C117 A2-B1-C118 A2-B1-C119 A2-B1-C120
A2-BI-C121 A2-B1-C122 A2-B1-C123 A2-B1-C124 A2-B1-C125 A2-B1-C126
A2-B1-C127 A2-B1-C128 A2-B1-C129 A2-B1-C130 A2-B1-C131 A2-B1-C132
A2-B1-C133 A2-B1-C134 A2-B1-C135 A2-B1-C136 A2-B1-C137 A2-B1-C138
A2-B1-C139 A2-B1-CI40 BLANK BLANK BLANK BLANK
A2-B2-C1 A2-B2-C2 A2-B2-C3 A2-B2-C4 A2-B2-C5 A2-B2-C6
A2-B2-C7 A2-B2-C8 A2-B2-C9 A2-B2-C10 A2-B2-C11 A2-B2-C12
A2-B2-C13 A2-B2-C14 A2-B2-C15 A2-B2-C16 A2-B2-C17 A2-B2-C18
A2-B2-CI9 A2-B2-C20 A2-B2-C21 A2-B2-C22 A2-B2-C23 A2-B2-C24
A2-B2-C25 A2-B2-C26 A2-B2-C27 A2-B2-C28 A2-B2-C29 A2-B2-C30
A2-B2-C31 A2-B2-C32 A2-B2-C33 A2-B2-C34 A2-B2-C35 A2-B2-C36
A2-B2-C37 A2-B2-C38 A2-B2-C39 A2-B2-C40 A2-B2-C41 A2-B2-C42
A2-B2-C43 A2-B2-C44 A2-B2-C45 A2-B2-C46 A2-B2-C47 A2-B2-C48
A2-B2-C49 A2-B2-C50 A2-B2-C51 A2-B2-C52 A2-B2-C53 A2-B2-C54
A2-B2-C55 A2-B2-C56 A2-B2-C57 A2-B2-C58 A2-B2-C59 A2-B2-C60
A2-B2-C61 A2-B2-C62 A2-B2-C63 A2-B2-C64 A2-B2-C65 A2-B2-C66
A2-B2-C67 A2-B2-C68 A2-B2-C69 A2-B2-C70 A2-B2-C71 A2-B2-C72
A2-B2-C73 A2-B2-C74 A2-B2-C75 A2-B2-C76 A2-B2-C77 A2-B2-C78
A2-B2-C79 A2-B2-C80 A2-B2-C81 A2-B2-C82 A2-B2-C83 A2-B2-C84
A2-B2-C85 A2-B2-C86 A2-B2-C87 A2-B2-C88 A2-B2-C89 A2-B2-C90
A2-B2-C91 A2-B2-C92 A2-B2-C93 A2-B2-C94 A2-B2-C95 A2-B2-C96

A2-B2-C97 A2-B2-C98 A2-B2.C99 A2-B2-C100 A2-B2-C101 A2-B2-C102
A2-B2-C103 A2-B2-C104 A2-B2-C105 A2-B2-C106 A2-B2-C107 A2-B2-C108
A2-B2-C109 A2-B2-C110 A2-B2-C111 A2-B2-C112 A2-B2-C113 A2-B2-C114
A2-B2-C115 A2-B2-C116 A2-B2.C 117 A2-B2-C118 A2-B2-C119 A2-B2-C120
A2-B2-C121 A2-B2-C122 A2-B2-C123 A2-B2-C 124 A2-B2-C125 A2-B2'C 126
A2-B2-C127 A2-B2-C128 A2-B2.C 129 A2-B2-C130 A2-B2-C131 A2-B2-C132
A2-B2-CI33 A2-B2-C134 A2-B2.C135 A2-B2-C136 A2-B2-C137 A2-B2-C138
A2-B2-C139 A2-B2-C140 BLANK BLANK BLANK BLANK
A2-B3-C1 A2-B3-C2 A2-B3-C3 A2-B3-C4 A2-B3-C5 A2-B3-C6
A2-B3-C7 A2-B3-C8 A2-B3-C9 A2-B3-C10 A2-B3-C11 A2-B3-C12
A2-B3-C13 A2-B3-C14 A2-B3-C15 A2-B3-C16 A2-B3-C17 A2-B3-C18
A2-B3-C19 A2-B3-C20 A2-B3-C21 A2-B3-C22 A2-B3-C23 A2-B3-C24
A2-B3-C25 A2-B3-C26 A2-B3-C27 A2-B3-C28 A2-B3-C29 A2-B3-C30
A2-B3-C31 A2-B3-C32 A2-B3-C33 A2-B3-C34 A2-B3-C35 A2-B3-C36
A2-B3-C37 A2-B3'C38 A2-B3-C39 A2-B3-C40 A2-B3-C41 A2-B3-C42
A2-B3-C43 A2-B3-C44 A2-B3-C45 A2-B3-C46 A2-B3-C47 A2-B3-C48
A2-B3-C49 A2-B3-C50 A2-B3-C51 A2-B3-C52 A2-B3-C53 A2-B3-C54
A2-B3-C55 A2-B3-C56 A2-B3-C57 A2-B3-C58 A2-B3-C59 A2-B3-C60
A2-B3-C61 A2-B3-C62 A2-B3-C63 A2-B3-C64 A2-B3-C65 A2-B3-C66
A2-B3-C67 A2-B3-C68 A2-B3-C69 A2-B3-C70 A2-B3-C71 A2-B3-C72
A2-B3-C73 A2-B3-C74 A2-B3-C75 A2-B3-C76 A2-B3-C77 A2-B3-C78
A2-B3-C79 A2-B3-C80 A2-B3-C81 A2-B3-C82 A2-B3-C83 A2-B3-C84
A2-B3-C85 A2-B3-C86 A2-B3-C87 A2-B3-C88 A2-B3-C89 A2-B3-C90
A2-B3-C91 A2-B3-C92 A2-B3-C93 A2-B3-C94 A2-B3-C95 A2-B3-C96
A2-B3-C97 A2-B3-C98 A2-B3-C99 A2-B3-C100 A2-B3-C101 A2-B3-C102
A2-B3-C103 A2-B3-C104 A2-B3-C105 A2-B3-C106 A2-B3-C107 A2-B3-C108
A2-B3-CI09 A2-B3-C110 A2-B3-C111 A2-B3-C112 A2-B3-C113 A2-B3-C114
A2-B3-C115 A2-B3-C116 A2-B3-C117 A2-B3-C118 A2-B3-C119 A2-B3-C120
A2-B3-C121 A2-B3-C122 A2-B3-C123 A2-B3-C124 A2-B3-C125 A2-B3-C126
A2-B3-C127 A2-B3-C128 A2-B3-C129 A2-B3-C130 A2-B3-C131 A2-B3-C132
A2-B3-C133 A2-B3-C134 A2-B3-C135 A2-B3-C136 A2-B3-C137 A2-B3-C138
A2-B3-C139 A2-B3-C140 BLANK BLANK BLANK BLANK
A2-B4-C1 A2-B4-C2 A2-B4-C3 A2-B4-C4 A2-B4-C5 A2-B4-C6
A2-B4-C7 A2-B4-C8 A2-B4-C9 A2-B4-C10 A2-B4-C11 A2-B4-C12
A2-B4-C13 A2-B4-C14 A2-B4-C15 A2-B4-C16 A2-B4-C17 A2-B4-C18
A2-B4-C19 A2-B4-C20 A2-B4-C21 A2-B4-C22 A2-B4-C23 A2-B4-C24
A2-B4-C25 A2-B4-C26 A2-B4-C27 A2-B4-C28 A2-B4-C29 A2-B4-C30

A2-B4-C31 A2-B4-C32 A2-B4-C33 A2-B4-C34 A2-B4-C35 A2-B4-C36
A2-B4-C37 A2-B4-C38 A2-B4-C39 A2-B4-C40 A2-B4-C4I A2-B4-C42
A2-B4-C43 A2-B4-C44 A2-B4-C45 A2-B4-C46 A2-B4-C47 A2-B4-C48
A2-B4-C49 A2-B4-C50 A2-B4-C51 A2-B4-C52 A2-B4-C53 A2-B4-C54
A2-B4-C55 A2-B4-C56 A2-B4-C57 A2-B4-C58 A2-B4-C59 A2-B4-C60
A2-B4-C61 A2-B4-C62 A2-B4-C63 A2-B4-C64 A2-B4-C65 A2-B4-C66
A2-B4-C67 A2-B4-C68 A2-B4-C69 A2-B4-C70 A2-B4-C71 A2-B4-C72
A2-B4-C73 A2-B4-C74 A2-B4-C75 A2-B4-C76 A2-B4-C77 A2-B4-C78
A2-B4-C79 A2-B4-C80 A2-B4-C81 A2-B4-C82 A2-B4-C83 A2'B4-C84
A2~B4-C85 A2-B4-C86 A2-B4-C87 A2-B4-C88 A2-B4-C89 A2-B4-C90
A2-B4-C91 A2-B4-C92 A2-B4-C93 A2-B4-C94 A2-B4-C95 A2-B4-C96
A2-B4-C97 A2-B4-C98 A2-B4-C99 A2-B4-C100 A2-B4-C101 A2-B4-C102
A2-B4-C103 A2-B4-C104 A2-B4-C105 A2-B4-C106 A2-B4-C107 A2-B4-C108
A2-B4-C*l 09 A2-B4-C110 A2-B4-C111 A2-B4-C112 A2-B4-C113 A2-B4-C114
A2-B4-C115 A2-B4-C116 A2-B4-C117 A2-B4-C118 A2-B4-C119 A2-B4-C120
A2-B4-C121 A2-B4-C122 A2-B4-C123 A2-B4-C 124 A2-B4-C125 A2-B4-C126
A2-B4-C127 A2-B4-C128 A2-B4-C129 A2-B4-C130 A2-B4-C131 A2'B4-C 132
A2-B4'C 133 A2-B4-C134 A2-B4-C135 A2-B4-C136 A2-B4-C13 7 A2-B4-C13 8
A2-B4-C139 A2-B4-C140 BLANK BLANK BLANK BLANK
A2-B5-C1 A2-B5-C2 A2-B5-C3 A2-B5-C4 A2-B5-C5 A2-B5-C6
A2-B5-C7 A2-B5-C8 A2-B5-C9 A2-B5-CI0 A2-B5-CI1 A2-B5-C12
A2-B5-C13 A2-B5-C 14 A2-B5-C15 A2-B5-C16 A2-B5-C17 A2-B5-C18
A2-B5-C19 A2'B5-C20 A2-B5-C2 ] A2-B5-C22 A2-B5-C23 A2-B5-C24
A2-B5-C25 A2-B5-C26 A2-B5-C27 A2-B5-C28 A2-B5-C29 A2-B5-C30
A2-B5-C31 A2-B5-C32 A2-B5-C33 A2-B5-C34 A2-B5-C35 A2-B5-C36
A2-B5-C37 A2-B5-C38 A2-B5-C39 A2-B5-C40 A2-B5-C41 A2-B5-C42
A2-B5-C43 A2-B5-C44 A2-B5-C45 A2-B5-C46 A2-B5-C47 A2-B5-C48
A2-B5-C49 A2-B5-C50 A2-B5-C51 A2-B5-C52 A2-B5-C53 A2-B5-C54
A2-B5-C55 A2-B5-C56 A2-B5-C57 A2-B5-C58 A2-B5-C59 A2-B5-C60
A2-B5-C61 A2-B5-C62 A2-B5-C63 A2-B5-C64 A2-B5-C65 A2-B5-C66
A2-B5-C67 A2-B5-C68 A2-B5-C69 A2-B5-C70 A2-B5-C71 A2-B5-C72
A2-B5-C73 A2-B5-C74 A2-B5-C75 A2-B5-C76 A2-B5-C77 A2-B5-C78
A2-B5-C79 A2-B5-C80 A2-B5-C81 A2-B5-C82 A2-B5-C83 A2-B5-C84
A2-B5-C85 A2-B5-C86 A2-B5-C87 A2-B5-C88 A2-B5-C89 A2-B5-C90
A2-B5-C91 A2-B5-C92 A2-B5-C93 A2-B5-C94 A2-B5-C95 A2-B5-C96
A2-B5-C97 A2-B5-C98 A2-B5-C99 A2-B5-C100 A2-B5-C101 A2-B5-C102
A2-B5-C103 A2-B5-C104 A2-B5-C105 A2-B5-C106 A2-B5-C107 A2-B5-C108

A2-B5-C109 A2-B5-C110 A2-B5-C111 A2-B5-C112 A2-B5-C113 A2-B5-C114
A2-B5-C115 A2-B5-Cn6 A2-B5-C117 A2-B5-C118 A2-B5-C119 A2-B5-C120
A2-B5-C12] A2-B5-C122 A2-B5-C123 A2-B5-C124 A2-B5-C125 A2-B5-C126
A2-B5-C127 A2-B5-C128 A2-B5-C129 A2-B5-C130 A2-B5-C131 A2-B5-C132
A2-B5-C133 A2-B5-C134 A2-B5-C135 A2-B5-C136 A2-B5-C137 A2-B5-C138
A2-B5-C139 A2-B5-C140 BLANK BLANK BLANK BLANK
A2-B6-C1 A2-B6-C2 A2-B6-C3 A2-B6-C4 A2-B6-C5 A2-B6-C6
A2-B6-C7 A2-B6-C8 A2-B6-C9 A2-B6-C10 A2-B6-C1I A2-B6-C12
A2-B6-C13 A2-B6-C14 A2-B6-C15 A2-B6-C16 A2-B6-C17 A2-B6-C18
A2-B6-C19 A2-B6-C20 A2-B6-C21 A2-B6-C22 A2-B6-C23 A2-B6-C24
A2-B6-C25 A2-B6-C26 A2-B6-C27 A2-B6-C28 A2-B6-C29 A2-B6-C30
A2-B6-C31 A2-B6-C32 A2-B6-C33 A2-B6-C34 A2-B6-C35 A2-B6-C36
A2-B6-C37 A2-B6-C38 A2-B6-C39 A2-B6-C40 A2-B6-C41 A2-B6-C42
A2-B6-C43 A2-B6-C44 A2-B6-C45 A2-B6-C46 A2-B6-C47 A2-B6-C48
A2-B6-C49 A2-B6-C50 A2-B6-C51 A2-B6-C52 A2-B6-C53 A2-B6-C54
A2-B6-C55 A2-B6-C56 A2-B6-C57 A2-B6-C58 A2-B6-C59 A2-B6-C60
A2-B6-C61 A2-B6-C62 A2-B6-C63 A2-B6-C64 A2-B6-C65 A2-B6-C66
A2-B6-C67 A2-B6-C68 A2-B6-C69 A2-B6-C70 A2-B6-C71 A2-B6-C72
A2-B6-C73 A2-B6-C74 A2-B6-C75 A2-B6-C76 A2-B6-C77 A2-B6-C78
A2-B6-C79 A2-B6-C80 A2-B6-C8I A2-B6-C82 A2-B6-C83 A2-B6-C84
A2-B6-C85 A2-B6-C86 A2-B6-C87 A2-B6-C88 A2-B6-C89 A2-B6-C90
A2-B6-C91 A2-B6-C92 A2-B6-C93 A2-B6-C94 A2-B6-C95 A2-B6-C96
A2-B6-C97 A2-B6-C98 A2-B6-C99 A2-B6-C100 A2-B6-C101 A2-B6-C102
A2-B6-C103 A2-B6-C104 A2-B6-C105 A2-B6-C106 A2-B6-C107 A2-B6-C108
A2-B6-C109 A2-B6-C110 A2-B6-C111 A2-B6-C112 A2-B6-C113 A2-B6-C114
A2-B6-C115 A2-B6-Cn6 A2-B6-C117 A2-B6-C118 A2-B6-Cn9 A2-B6-C120
A2-B6-C121 A2-B6-C122 A2-B6-C123 A2-B6-C124 A2-B6-C125 A2-B6-C126
A2-B6-C127 A2-B6-C128 A2-B6-C129 A2-B6-C130 A2-B6-C131 A2-B6-C132
A2-B6-C133 A2-B6-C134 A2-B6-C135 A2-B6-C136 A2-B6-C137 A2-B6-C138
A2-B6-C139 A2-B6-C140 BLANK BLANK BLANK BLANK
A2-B7-C1 A2-B7-C2 A2-B7-C3 A2-B7-C4 A2-B7-C5 A2-B7-C6
A2-B7-C7 A2-B7-C8 A2-B7-C9 A2-B7-C10 A2-B7-C11 A2-B7-C12
A2-B7-C13 A2-B7-C14 A2-B7-C15 A2-B7-C16 A2-B7-C17 A2-B7-C18
A2-B7-C19 A2-B7-C20 A2-B7-C21 A2-B7-C22 A2-B7-C23 A2-B7-C24
A2-B7-C25 A2-B7-C26 A2-B7-C27 A2-B7-C28 A2-B7-C29 A2-B7-C30
A2-B7-C31 A2-B7-C32 A2-B7-C33 A2-B7-C34 A2-B7-C35 A2-B7-C36
A2-B7-C37 A2-B7-C38 A2-B7-C39 A2-B7-C40 A2-B7-C41 A2-B7-C42

A2-B7-C43 A2-B7-C44 A2-B7-C45 A2-B7-C46 A2-B7-C47 A2-B7-C48
A2-B7-C49 A2-B7-C50 A2-B7-.C51 A2-B7-C52 A2-B7-C53 A2-B7-C54
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A2-B7-C139 A2-B7-C140 BLANK BLANK BLANK BLANK
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A2-B8-C115 A2-B8-C116 A2-B8-C117 A2-B8-C118 A2-B8-C119 A2-B8-C120

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A2-B8-C127 A2-B8-C128 A2-B8-C129 A2-B8-C130 A2-B8-C131 A2-B8-C132
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A2-B8-C139 A2-B8-C140 BLANK BLANK BLANK BLANK
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A2-B9-C127 A2-B9-C128 A2-B9-C129 A2-B9-C130 A2-B9-C131 A2-B9-C132
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A2-B9-C139 A2-B9-C140 BLANK BLANK BLANK BLANK
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A2-B10-C49 A2-B10-C50 A2-B10-C51 A2-B10-C52 A2-B10-C53 A2-B10-C54

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A2-B10-C139 A2-B10-C140 BLANK BLANK BLANK BLANK
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A2-B11-C127 A2-B11-C128 A2-B11-C129 A2-B11-C130 A2-B11-C131 A2-B11-C132

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A2-BI1-C139 A2-B11-C140 BLANK BLANK BLANK BLANK
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A2-B12-C139 A2-B12-C140 BLANK BLANK BLANK BLANK
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A2-B13-C133 A2-B13-C134 A2-B13-C135 A2-B13-C136 A2-B13-C137 A2-B13-C138
A2-B13-C139 A2-B13-C140 BLANK BLANK BLANK BLANK
A3-B1-C1 A3-B1-C2 A3-B1-C3 A3-B1-C4 A3-B1-C5 A3-B1-C6
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A3-B1-C37 A3-B1-C38 A3-B1-C39 A3-B1-C40 A3-B1-C4I A3-B1-C42
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A3-B1-C55 A3-B1-C56 A3-B1-C57 A3-B1-C58 A3-B1-C59 A3-B1-C60
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A3-B1-C139 A3-B1-C140 BLANK BLANK BLANK BLANK

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A3-B2-C127 A3-B2-C128 A3-B2-C129 A3-B2-C130 A3-B2-C131 A3-B2-C132
A3-B2-C133 A3-B2-C134 A3-B2-C135 A3-B2-C136 A3-B2-C137 A3-B2-C138
A3-B2-CI39 A3-B2-CI40 BLANK BLANK BLANK BLANK
A3-B3-C1 A3-B3-C2 A3-B3-C3 A3-B3-C4 A3-B3-C5 A3-B3-C6
A3-B3-C7 A3-B3-C8 A3-B3-C9 A3-B3-C10 A3-B3-C11 A3-B3-C12
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A3-B3-C73 A3-B3-C74 A3-B3-C75 A3-B3-C76 A3-B3-C77 A3-B3-C78

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A3-B3'C127 A3-B3-C128 A3-B3-CI29 A3-B3-C130 A3-B3-C131 A3-B3-C132
A3-B3-C133 A3-B3-C134 A3~B3-C135 A3-B3-C136 A3-B3-C137 A3-B3-C138
A3-B3-C139 A3-B3-C140 BLANK BLANK BLANK BLANK
A3-B4-C1 A3-B4-C2 A3-B4-C3 A3-B4-C4 A3-B4-C5 A3-B4-C6
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A3-B4-C49 A3-B4-C50 A3-B4-C51 A3-B4-C52 A3-B4-C53 A3-B4-C54
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A3-B4-C133 A3-B4-C134 A3-B4-C135 A3-B4-C136 A3-B4-C137 A3-B4-C138
A3-B4-C139 A3-B4-C140 BLANK BLANK BLANK BLANK
A3-B5-C1 A3-B5-C2 A3-B5-C3 A3-B5-C4 A3-B5-C5 A3-B5-C6
A3-B5-C7 A3-B5-C8 A3-B5-C9 A3-B5-C10 A3-B5-C11 A3-B5-C12

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A3-B5-C103 A3-B5-C104 A3-B5-C105 A3-B5-C106 A3-B5-C107 A3-B5-C108
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A3-B5-C121 A3-B5-C122 A3-B5-C123 A3-B5-C124 A3-B5-C125 A3-B5-C126
A3-B5-C127 A3-B5-C128 A3-B5-C129 A3-B5-C130 A3-B5-C131 A3-B5-C132
A3-B5-C133 A3-B5-C134 A3-B5-C135 A3-B5-C136 A3-B5-C137 A3-B5-C138
A3-B5-C139 A3-B5-C140 BLANK BLANK BLANK BLANK
A3-B6-C1 A3-B6-C2 A3-B6-C3 A3-B6-C4 A3-B6-C5 A3-B6-C6
A3-B6-C7 A3-B6'C8 A3-B6-C9 A3-B6-C10 A3'B6-C11 A3-B6-C12
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A3-B6'C31 A3-B6-C32 A3-B6-C33 A3-B6-C34 A3-B6-C35 A3-B6-C36
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A3-B6-C49 A3-B6-C50 A3-B6-C51 A3-B6-C52 A3-B6-C53 A3-B6-C54
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A3-B6-C103 A3-B6-C104 A3-B6-C105 A3-B6-C106 A3-B6-C107 A3-B6-C108
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A3-B6-C115 A3-B6-C116 A3-B6-C117 A3-B6-C118 A3-B6-C119 A3-B6-C120
A3-B6-C121 A3-B6-C122 A3-B6-C123 A3-B6-C124 A3-B6-C125 A3-B6-C126
A3-B6-C127 A3-B6-C128 A3-B6-C129 A3-B6-C130 A3-B6-C131 A3-B6-C132
A3-B6-C133 A3-B6-C134 A3-B6-C135 A3-B6-C136 A3-B6-C137 A3-B6-C138
A3-B6-C139 A3-B6-C140 BLANK BLANK BLANK BLANK
A3-B7-C1 A3-B7-C2 A3-B7-C3 A3-B7-C4 A3-B7-C5 A3-B7-C6
A3-B7-C7 A3-B7-C8 A3-B7-C9 A3-B7-C10 A3-B7-C11 A3-B7-C12
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A3-B7-C19 A3-B7-C20 A3-B7-C21 A3-B7-C22 A3-B7-C23 A3-B7-C24
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A3-B7-C127 A3-B7-C128 A3-B7'C129 A3-B7-C130 A3-B7-C131 A3-B7-C132
A3-B7-C133 A3-B7-C134 A3-B7-C135 A3-B7-C136 A3-B7-C137 A3-B7-C138
A3-B7-C139 A3-B7-C140 BLANK BLANK BLANK BLANK
A3-B8-C1 A3-B8-C2 A3-B8-C3 A3-B8-C4 A3-B8-C5 A3-B8-C6
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A3-B8-C103 A3-B8-C104 A3-B8-C105 A3-B8-C106 A3-B8-C107 A3-B8-C108
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A3-B8-C133 A3-B8-C134 A3-B8-C135 A3-B8-C136 A3-B8-C137 A3-B8-C138
A3-B8-C139 A3-B8-C140 BLANK BLANK BLANK BLANK
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A3-B9-C97 A3-B9-C98 A3-B9-C99 A3-B9-C100 A3-B9-C101 A3-B9-C102

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A3-B9-C109 A3-B9-C110 A3-B9-C111 A3-B9-C112 A3-B9-C113 A3-B9-C114
A3-B9-C115 A3-B9-C116 A3-B9-C117 A3-B9-C118 A3-B9-C119 A3-B9-C120
A3-B9-C121 A3-B9-C122 A3-B9-CI23 A3-B9-C124 A3-B9-C125 A3-B9-C126
A3-B9-C127 A3-B9-C128 A3-B9-C129 A3-B9-C130 A3-B9-C131 A3-B9-C132
A3-B9-C133 A3-B9-C134 A3-B9-C135 A3-B9-C136 A3-B9-C137 A3-B9-C138
A3-B9-CI39 A3-B9-C140 BLANK BLANK BLANK BLANK
A3-B10-C1 A3-B10-C2 A3-B10-C3 A3-B10-C4 A3-B10-C5 A3-B10-C6
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A3-B10-C127 A3-B10-C128 A3-B10-C129 A3-B10-C130 A3-B10-C131 A3-B10-C132
A3-B10-C133 A3-B10-C134 A3-B10-C135 A3-B10-C136 A3-B10-C137 A3-B10-C138
A3-B10-C139 A3-B10-C140 BLANK BLANK BLANK BLANK
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A3-B11-C139 A3-B11-C140 BLANK BLANK BLANK BLANK
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A3-B12-C109 A3-B12-C110 A3-B12-C111 A3-B12-C112 A3-B12-C113 A3-B12-C114

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A3-B12-C127 A3-B12-C128 A3-B12-C129 A3-B12-C130 A3-B12-C131 A3-B12-C132
A3-B12-C133 A3-B12-C134 A3-B12-C135 A3-B12-C136 A3-B12-C137 A3-B12-C138
A3-B12-C139 A3-B12-C140 BLANK BLANK BLANK BLANK
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A3-B13-C139 A3-B13-C140 BLANK BLANK BLANK BLANK
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A4-B1-C127 A4-B1-C128 A4-B1-C129 A4-B1-C130 A4-B1-C131 A4-B1-C132
A4-B1-C133 A4-B1-C134 A4-B1-C135 A4-B1-C136 A4-B1-CI37 A4-B1-C138
A4-B1-C139 A4-B1-C140 BLANK BLANK BLANK BLANK
A4-B2-C1 A4-B2-C2 A4-B2-C3 A4-B2-C4 A4-B2-C5 A4-B2-C6
A4-B2-C7 A4-B2-C8 A4-B2-C9 A4-B2-C10 A4-B2-C11 A4-B2-C12
A4-B2-C13 A4-B2-C14 A4-B2-C15 A4-B2-C16 A4-B2-C17 A4-B2-C18
A4-B2-C19 A4-B2-C20 A4-B2-C21 A4-B2-C22 A4-B2-C23 A4-B2-C24
A4-B2-C25 A4-B2-C26 A4-B2-C27 A4-B2-C28 A4-B2-C29 A4-B2-C30
A4-B2-C31 A4-B2-C32 A4-B2-C33 A4-B2-C34 A4-B2-C35 A4-B2-C36
A4-B2-C37 A4-B2-C38 A4-B2-C39 A4-B2-C40 A4-B2-C41 A4-B2-C42
A4-B2-C43 A4-B2-C44 A4-B2-C45 A4-B2-C46 A4-B2-C47 A4-B2-C48
A4-B2-C49 A4-B2-C50 A4-B2-C51 A4-B2-C52 A4-B2-C53 A4-B2-C54
A4-B2-C55 A4-B2-C56 A4-B2-C57 A4-B2-C58 A4-B2-C59 A4-B2-C60
A4-B2-C61 A4-B2-C62 A4-B2-C63 A4-B2-C64 A4-B2-C65 A4-B2-C66
A4-B2-C67 A4-B2-C68 A4-B2-C69 A4-B2-C70 A4-B2-C71 A4-B2-C72
A4-B2-C73 A4-B2-C74 A4-B2-C75 A4-B2-C76 A4-B2-C77 A4-B2-C78
A4-B2-C79 A4-B2-C80 A4-B2-C81 A4-B2-C82 A4-B2-C83 A4-B2-C84
A4-B2-C85 A4-B2-C86 A4-B2-C87 A4-B2-C88 A4-B2-C89 A4-B2-C90
A4-B2-C91 A4-B2-C92 A4-B2-C93 A4-B2-C94 A4-B2-C95 A4-B2-C96
A4-B2-C97 A4-B2-C98 A4-B2-C99 A4-B2-C100 A4-B2-C101 A4-B2-C102
A4-B2-C103 A4-B2-C104 A4-B2-C105 A4-B2-C106 A4-B2-C107 A4-B2-C108
A4-B2-C109 A4-B2-C110 A4-B2-C111 A4-B2-C112 A4-B2-C113 A4-B2-C1I4
A4-B2-C115 A4-B2-C116 A4-B2-C117 A4-B2-Cn8 A4-B2-Cn9 A4-B2-C120
A4-B2-C121 A4-B2-C122 A4-B2-C123 A4-B2-C124 A4-B2-C125 A4-B2-C126

A4-B2-C127 A4-B2-C128 A4-B2-C129 A4-B2-C130 A4-B2-C131 A4-B2-C132
A4-B2-C133 A4-B2-C134 A4-B2-C135 A4-B2-C136 A4-B2-C137 A4-B2-C138
A4-B2'C139 A4-B2-CI40 BLANK BLANK BLANK BLANK
A4-B3-C1 A4-B3-C2 A4-B3-C3 A4-B3-C4 A4-B3-C5 A4-B3-C6
A4-B3-C7 A4-B3-C8 A4-B3-C9 A4-B3-C10 A4-B3-C11 A4-B3-C 12
A4-B3-C13 A4-B3-C14 A4-B3-C15 A4-B3-C16 A4-B3-C17 A4-B3-C18
A4-B3-C19 A4-B3-C20 A4-B3-C2I A4-B3-C22 A4-B3-C23 A4-B3-C24
A4-B3-C25 A4-B3-C26 A4-B3-C27 A4-B3-C28 A4-B3-C29 A4-B3-C30
A4-B3-C31 A4-B3-C32 A4-B3-C33 A4-B3-C34 A4-B3-C35 A4-B3-C36
A4-B3-C37 A4'B3-C38 A4-B3-C39 A4-B3-C40 A4-B3-C41 A4-B3-C42
A4-B3-C43 A4-B3-C44 A4-B3-C45 A4-B3-C46 A4'B3-C47 A4-B3-C48
A4-B3-C49 A4-B3-C50 A4-B3-C51 A4-B3-C52 A4-B3-C53 A4-B3-C54
A4-B3-C55 A4-B3-C56 A4-B3-C57 A4-B3-C58 A4-B3-C59 A4-B3-C60
A4-B3-C61 A4-B3-C62 A4-B3-C63 A4-B3-C64 A4-B3-C65 A4-B3-C66
A4-B3-C67 A4-B3-C68 A4-B3-C69 A4-B3-C70 A4-B3-C71 A4-B3-C72
A4-B3-C73 A4-B3-C74 A4-B3-C75 A4-B3-C76 A4-B3-C77 A4-B3-C78
A4-B3-C79 A4-B3-C80 A4-B3-C81 A4-B3-C82 A4-B3-C83 A4-B3-C84
A4-B3-C85 A4-B3-C86 A4'B3-C87 A4-B3-C88 A4-B3-C89 A4-B3-C90
A4-B3-C91 A4-B3-C92 A4-B3-C93 A4-B3-C94 A4-B3-C95 A4-B3-C96
A4-B3-C97 A4-B3-C98 A4-B3-C99 A4-B3-CI00 A4-B3-C101 A4-B3-C102
A4-B3-C103 A4-B3-C104 A4-B3-C105 A4-B3-C106 A4-B3-C107 A4-B3-C108
A4-B3-C109 A4-B3-C110 A4-B3-C111 A4-B3-C112 A4-B3-C113 A4-B3-C114
A4-B3-CI15 A4-B3-C116 A4-B3-C] 17 A4-B3-C118 A4-B3-C119 A4-B3-C120
A4-B3-C121 A4-B3-C122 A4-B3-C123 A4-B3-C124 A4-B3-C125 A4-B3-C126
A4-B3-C127 A4-B3-C128 A4-B3-C129 A4-B3-C130 A4-B3-C131 A4-B3-C132
A4-B3-C133 A4-B3-C134 A4-B3-C135 A4-B3-C136 A4-B3-C137 A4.B3-C138
A4-B3-C139 A4-B3-C140 BLANK BLANK BLANK BLANK
A4-B4-C1 A4-B4-C2 A4-B4-C3 A4-B4-C4 A4-B4-C5 A4-B4-C6
A4-B4-C7 A4-B4-C8 A4-B4-C9 A4-B4-C10 A4-B4-C11 A4-B4-C12
A4-B4-C 13 A4-B4-C14 A4-B4-C15 A4-B4-C16 A4-B4-C17 A4-B4-C18
A4-B4-C19 A4-B4-C20 A4-B4-C21 A4-B4-C22 A4-B4-C23 A4-B4-C24
A4-B4-C25 A4-B4-C26 A4-B4-C27 A4-B4-C28 A4-B4-C29 A4.B4-C30
A4-B4-C31 A4-B4-C32 A4-B4-C33 A4-B4-C34 A4-B4-C35 A4-B4-C36
A4-B4-C37 A4-B4-C38 A4-B4-C39 A4-B4-C40 A4-B4-C41 A4.B4-C42
A4-B4-C43 A4-B4-C44 A4-B4-C45 A4-B4-C46 A4.B4-C47 A4-B4-C48
A4.B4-C49 A4-B4-C50 A4-B4-C51 A4-B4-C52 A4-B4-C53 A4-B4-C54
A4-B4-C55 A4-B4-C56 A4-B4.C57 A4-B4-C58 A4-B4-C59 A4-B4-C60

A4-B4-C6I A4-B4-C62 A4-B4-C63 A4-B4-C64 A4-B4-C65 A4-B4-C66
A4-B4-C67 A4-B4-C68 A4-B4-C69 A4-B4-C70 A4-B4-C71 A4-B4-C72
A4-B4-C73 A4-B4-C74 A4-B4-C75 A4-B4-C76 A4-B4-C77 A4-B4-C78
A4-B4-C79 A4-B4-C80 A4-B4-C81 A4-B4-C82 A4-B4-C83 A4-B4-C84
A4-B4-C85 A4.B4-C86 A4-B4-C87 A4-B4-C88 A4-B4-C89 A4-B4-C90
A4-B4-C91 A4-B4-C92 A4-B4-C93 A4-B4-C94 A4-B4-C95 A4-B4-C96
A4-B4-C97 A4-B4-C98 A4-B4-C99 A4-B4-C100 A4-B4-C101 A4-B4-C102
A4-B4-C103 A4-B4-C104 A4-B4-C105 A4-B4-C106 A4-B4-C107 A4-B4-C108
A4-B4-C109 A4-B4-C110 A4-B4-C111 A4-B4-C112 A4-B4-C113 A4-B4-C114
A4-B4-C115 A4-B4-C116 A4-B4-C117 A4-B4-C118 A4-B4-C119 A4-B4-C120
A4-B4-C121 A4-B4-C122 A4-B4-C123 A4-B4-C124 A4-B4-C125 A4-B4-C126
A4-B4-C127 A4-B4-C128 A4-B4-C129 A4-B4-C130 A4-B4-C131 A4-B4-C132
A4-B4-C133 A4-B4-C134 A4-B4-C135 A4-B4-C 136 A4-B4-C137 A4-B4-C138
A4-B4-C139 A4.B4-C140 BLANK BLANK BLANK BLANK
A4-B5-CI A4.B5-C2 A4-B5-C3 A4-B5-C4 A4-B5-C5 A4-B5-C6
A4-B5-C7 A4-B5-C8 A4-B5-C9 A4-B5-C10 A4-B5-C11 A4-B5-C12
A4-B5-C13 A4-B5-C14 A4-B5-C15 A4-B5-C16 A4-B5-C17 A4-B5-C18
A4-B5-C 19 A4-B5-C20 A4-B5-C21 A4-B5-C22 A4-B5-C23 A4-B5-C24
A4-B5-C25 A4-B5-C26 A4-B5-C27 A4-B5-C28 A4-B5-C29 A4-B5-C30
A4-B5-C31 A4-B5-C32 A4-B5-C33 A4-B5-C34 A4-B5-C35 A4-B5-C36
A4-B5-C37 A4-B5-C38 A4-B5-C39 A4-B5-C40 A4-B5-C41 A4-B5-C42
A4-B5-C43 A4-B5-C44 A4-B5-C45 A4-B5-C46 A4-B5-C47 A4-B5-C48
A4-B5-C49 A4-B5-C50 A4-B5-C51 A4-B5-C52 A4-B5-C53 A4-B5-C54
A4-B5-C55 A4-B5-C56 A4-B5-C57 A4-B5-C58 A4-B5-C59 A4-B5-C60
A4-B5-C61 A4-B5-C62 A4-B5-C63 A4-B5-C64 A4-B5-C65 A4-B5-C66
A4-B5-C67 A4-B5-C68 A4-B5-C69 A4-B5-C70 A4-B5-C7] A4-B5-C72
A4-B5-C73 A4-B5-C74 A4-B5-C75 A4-B5-C76 A4-B5-C77 A4-B5-C78
A4-B5-C79 A4-B5-C80 A4-B5-C81 A4-B5-C82 A4-B5-C83 A4-B5-C84
A4-B5-C85 A4-B5-C86 A4-B5-C87 A4-B5-C88 A4-B5-C89 A4-B5-C90
A4-B5-C91 A4-B5-C92 A4-B5-C93 A4-B5-C94 A4-B5-C95 A4-B5-C96
A4-B5-C97 A4-B5-C98 A4-B5-C99 A4-B5-C100 A4-B5-C101 A4-B5-C102
A4-B5-C103 A4-B5'C 104 A4-B5-C105 A4-B5-C106 A4-B5-C107 A4-B5-C108
A4-B5-C109 A4-B5-C110 A4-B5-C111 A4-B5-C112 A4-B5-C113 A4-B5-C114
A4-B5-C115 A4-B5-C116 A4-B5-C117 A4-B5-C118 A4-B5-C119 A4-B5-C120
A4-B5-C121 A4-B5-C122 A4-B5-C123 A4-B5-C124 A4-B5-C125 A4-B5-C126
A4-B5-C127 A4-B5'C 128 A4-B5-C129 A4-B5-C130 A4-B5-C131 A4-B5-C132
A4-B5-C133 A4-B5-C134 A4-B5-C135 A4-B5-C136 A4-B5-C137 A4-B5-C138

A4-B5-C139 A4-B5-C140 BLANK BLANK BLANK BLANK
A4-B6-C1 A4-B6-C2 A4-B6-C3 A4-B6-C4 A4-B6-C5 A4-B6-C6
A4-B6-C7 A4-B6-C8 A4-B6-C9 A4-B6-C10 A4-B6-C1 1 A4-B6-C12
A4-B6-C13 A4-B6-C14 A4-B6-CI5 A4-B6-C16 A4-B6-C17 A4-B6-CI8
A4-B6-C19 A4-B6-C20 A4-B6-C21 A4-B6-C22 A4-B6-C23 A4-B6-C24
A4-B6-C25 A4-B6-C26 A4-B6-C27 A4-B6-C28 A4-B6-C29 A4-B6-C30
A4-B6-C31 A4-B6-C32 A4-B6-C33 A4-B6-C34 A4-B6-C35 A4-B6-C36
A4-B6-C37 A4-B6-C38 A4-B6-C39 A4-B6-C40 A4-B6-C41 A4-B6-C42
A4-B6-C43 A4-B6-C44 A4-B6-C45 A4-B6-C46 A4-B6-C47 A4-B6-C48
A4-B6-C49 A4-B6-C50 A4-B6-C51 A4-B6-C52 A4-B6-C53 A4-B6-C54
A4-B6-C55 A4-B6-C56 A4-B6-C57 A4-B6-C58 A4-B6-C59 A4-B6-C60
A4-B6-C61 A4-B6-C62 A4-B6-C63 A4-B6-C64 A4-B6-C65 A4-B6-C66
A4-B6-C67 A4-B6-C68 A4-B6-C69 A4-B6-C70 A4-B6-C71 A4-B6-C72
A4-B6-C73 A4-B6-C74 A4-B6-C75 A4-B6-C76 A4-B6-C77 A4-B6-C78
A4-B6-C79 A4-B6-C80 A4-B6-C81 A4-B6-C82 A4-B6-C83 A4-B6-C84
A4-B6-C85 A4-B6-C86 A4-B6-C87 A4-B6-C88 A4-B6-C89 A4-B6-C90
A4-B6-C91 A4-B6-C92 A4-B6-C93 A4-B6-C94 A4-B6-C95 A4-B6-C96
A4-B6-C97 A4-B6-C98 A4-B6-C99 A4-B6-C100 A4-B6-C101 A4-B6-C102
A4-B6-C103 A4-B6-C104 A4-B6-C105 A4-B6-C106 A4-B6-CI07 A4-B6-C108
A4-B6-CI09 A4-B6-C110 A4-B6-C111 A4-B6-CI12 A4-B6-Cn3 A4-B6-CII4
A4-B6-C115 A4-B6-C1I6 A4-B6-C117 A4-B6-C118 A4-B6-C119 A4-B6-C120
A4-B6-CI21 A4-B6-C122 A4-B6-C123 A4-B6-C124 A4-B6-C125 A4-B6-C126
A4-B6-C127 A4-B6-C128 A4-B6-C129 A4-B6-C130 A4-B6-C131 A4-B6-C132
A4-B6-C133 A4-B6-C134 A4-B6-C135 A4-B6-C136 A4-B6-C137 A4-B6-C138
A4-B6-C139 A4-B6-C140 BLANK BLANK BLANK BLANK
A4-B7-CI A4-B7-C2 A4-B7-C3 A4-B7-C4 A4-B7-C5 A4-B7-C6
A4-B7-C7 A4-B7-C8 A4-B7-C9 A4-B7-C10 A4-B7-C11 A4-B7-C12
A4-B7-C13 A4-B7-C14 A4-B7-C15 A4-B7-CI6 A4-B7-C17 A4-B7-C18
A4-B7-C19 A4-B7-C20 A4-B7-C21 A4-B7-C22 A4-B7-C23 A4-B7-C24
A4-B7-C25 A4-B7-C26 A4-B7-C27 A4-B7-C28 A4-B7-C29 A4-B7-C30
A4-B7-C31 A4-B7-C32 A4-B7-C33 A4-B7-C34 A4-B7-C35 A4-B7-C36
A4-B7-C37 A4-B7-C38 A4-B7-C39 A4-B7-C40 A4-B7-C41 A4-B7-C42
A4-B7-C43 A4-B7-C44 A4-B7-C45 A4-B7-C46 A4-B7-C47 A4-B7-C48
A4-B7-C49 A4-B7-C50 A4-B7-C51 A4-B7-C52 A4-B7-C53 A4-B7-C54
A4-B7-C55 A4-B7-C56 A4-B7-C57 A4-B7-C58 A4-B7-C59 A4-B7-C60
A4-B7-C61 A4-B7-C62 A4-B7-C63 A4-B7-C64 A4-B7-C65 A4-B7-C66
A4-B7-C67 A4-B7-C68 A4-B7-C69 A4-B7-C70 A4-B7-C71 A4-B7-C72

A4-B7-C73 A4-B7-C74 A4-B7-C75 A4-B7-C76 A4-B7-C77 A4-B7-C78
A4-B7-C79 A4-B7-C80 A4-B7-C81 A4-B7-C82 A4-B7-C83 A4-B7-C84
A4-B7-C85 A4-B7-C86 A4-B7-C87 A4-B7-C88 A4-B7-C89 A4-B7-C90
A4-B7-C91 A4-B7-C92 A4-B7-C93 A4-B7-C94 A4-B7-C95 A4-B7-C96
A4-B7-C97 A4-B7-C98 A4-B7-C99 A4-B7-C100 A4-B7-C101 A4-B7-C102
A4-B7-C103 A4-B7-C104 A4-B7-C105 A4-B7-C106 A4-B7-C107 A4-B7-C108
A4-B7-C109 A4-B7-C110 A4-B7-C 111 A4-B7-C112 A4-B7-C113 A4-B7-C114
A4-B7-C115 A4-B7-C116 A4-B7-C117 A4-B7-C118 A4-B7-C119 A4-B7-C120
A4-B7-C121 A4-B7-C122 A4-B7-C123 A4-B7-C124 A4-B7-C125 A4-B7-C126
A4-B7-C127 A4-B7-C128 A4-B7-C129 A4-B7-C130 A4-B7-C131 A4-B7-C132
A4-B7-C133 A4-B7-C134 A4-B7-C135 A4-B7-C136 A4-B7-C137 A4-B7-C138
A4-B7-C139 A4-B7-C140 BLANK BLANK BLANK BLANK
A4-B8-C1 A4-B8-C2 A4-B8-C3 A4-B8-C4 A4-B8-C5 A4-B8-C6
A4-B8-C7 A4-B8-C8 A4-B8-C9 A4-B8-C10 A4-B8-C11 A4-B8-C12
A4-B8-C13 A4-B8-C14 A4-B8-C15 A4-B8-C16 A4-B8-C17 A4-B8-C18
A4-B8-C19 A4-B8-C20 A4-B8-C21 A4-B8-C22 A4-B8-C23 A4-B8-C24
A4-B8-C25 A4-B8-C26 A4-B8-C27 A4-B8-C28 A4-B8-C29 A4-B8-C30
A4-B8-C31 A4-B8-C32 A4-B8-C33 A4-B8-C34 A4-B8-C35 A4-B8-C36
A4-B8-C37 A4-B8-C38 A4-B8-C39 A4-B8-C40 A4-B8-C41 A4-B8-C42
A4-B8-C43 A4-B8-C44 A4-B8-C45 A4-B8-C46 A4-B8-C47 A4-B8-C48
A4-B8-C49 A4-B8-C50 A4-B8-C51 A4-B8-C52 A4-B8-C53 A4-B8-C54
A4-B8-C55 A4-B8-C56 A4-B8-C57 A4-B8-C58 A4-B8-C59 A4-B8-C60
A4-B8'C61 A4-B8-C62 A4-B8-C63 A4-B8-C64 A4-B8-C65 A4-B8-C66
A4-B8-C67 A4-B8-C68 A4-B8-C69 A4-B8-C70 A4-B8-C71 A4-B8-C72
A4-B8-C73 A4-B8-C74 A4-B8-C75 A4-B8-C76 A4-B8-C77 A4-B8-C78
A4-B8-C79 A4-B8-C80 A4-B8-C81 A4-B8-C82 A4-B8-C83 A4-B8-C84
A4-B8-C85 A4-B8-C86 A4-B8-C87 A4-B8-C88 A4-B8-C89 A4-B8-C90
A4-B8'C91 A4-B8-C92 A4-B8-C93 A4-B8-C94 A4-B8-C95 A4-B8-C96
A4-B8-C97 A4-B8-C98 A4-B8-C99 A4-B8-C100 A4-B8-C101 A4-B8-C102
A4-B8-C103 A4-B8-C104 A4-B8-C105 A4-B8™C 106 A4-B8-C107 A4-B8-C108
A4-B8-C109 A4-B8-C110 A4-B8-C111 A4-B8-C112 A4-B8-C113 A4-B8-C114
A4-B8-C1 ] 5 A4-B8-C116 A4-B8-C117 A4-B8-C118 A4-B8-C119 A4-B8-C120
A4-B8-C121 A4-B8-C122 A4-B8-C123 A4-B8-C124 A4-B8'C 125 A4-B8-C126
A4-B8-C127 A4-B8-C128 A4-B8-C129 A4-B8-C130 A4-B8-C131 A4-B8-C132
A4-B8-CI33 A4-B8-C134 A4-B8-C135 A4-B8-CI36 A4-B8-C137 A4-B8-CI38
A4-B8'C139 A4-B8-C140 BLANK BLANK BLANK BLANK
A4-B9-C1 A4-B9-C2 A4-B9-C3 A4-B9-C4 A4-B9-C5 A4-B9-C6

A4-B9-C7 A4-B9-C8 A4-B9-C9 A4-B9-C10 A4-B9-C11 A4-B9-C12
A4-B9-C13 A4-B9-C14 A4-B9-C15 A4-B9-C16 A4-B9-C17 A4-B9-C18
A4-B9-C19 A4-B9-C20 A4-B9-C21 A4-B9-C22 A4-B9-C23 A4-B9-C24
A4-B9-C25 A4-B9-C26 A4-B9-C27 A4-B9-C28 A4-B9-C29 A4-B9-C30
A4-B9-C31 A4-B9-C32 A4-B9-C33 A4-B9-C34 A4-B9-C35 A4-B9-C36
A4-B9-C37 A4-B9-C38 A4-B9-C39 A4-B9-C40 A4-B9-C4I A4-B9-C42
A4-B9-C43 A4-B9-C44 A4-B9-C45 A4-B9-C46 A4-B9-C47 A4-B9'C48
A4-B9-C49 A4-B9-C50 A4-B9-C51 A4-B9-C52 A4-B9-C53 A4-B9-C54
A4-B9-C55 A4-B9-C56 A4-B9-C57 A4-B9-C58 A4-B9-C59 A4-B9-C60
A4-B9-C61 A4-B9-C62 A4-B9-C63 A4-B9-C64 A4-B9-C65 A4-B9-C66
A4-B9-C67 A4-B9-C68 A4-B9-C69 A4-B9-C70 A4-B9-C71 A4-B9-C72
A4-B9-C73 A4-B9-C74 A4'B9-.C75 A4-B9-C76 A4-B9-C77 A4-B9-C78
A4-B9-C79 A4-B9-C80 A4-B9-C81 A4-B9-C82 A4-B9-C83 A4-B9-C84
A4-B9-C85 A4-B9-C86 A4-B9-C87 A4-B9-C88 A4-B9-C89 A4-B9-C90
A4-B9-C91 A4-B9-C92 A4-B9-C93 A4-B9-C94 A4-B9-C95 A4-B9-C96
A4-B9-C97 A4-B9-C98 A4-B9-C99 A4'B9-C 100 A4-B9-C101 A4-B9-C102
A4-B9-C103 A4-B9-C104 A4-B9-C105 A4-B9-C106 A4-B9-C107 A4'B9-C 108
A4-B9-C109 A4-B9-C110 A4-B9-C111 A4-B9-C112 A4-B9-C113 A4-B9-C114
A4-B9-C115 A4-B9-C116 A4-B9-C117 A4-B9-C118 A4-B9-C119 A4-B9-C 120
A4-B9-C121 A4-B9-C122 A4-B9-C123 A4-B9-C124 A4-B9-C125 A4-B9-C126
A4-B9-C127 A4-B9-C128 A4-B9-C129 A4-B9-C130 A4-B9-C131 A4-B9-C132
A4-B9-C133 A4-B9-C134 A4-B9-C135 A4-B9-C136 A4-B9-C137 A4-B9-C138
A4-B9-C139 A4-B9-C140 BLANK BLANK BLANK BLANK
A4-B10-C1 A4-B10-C2 A4-B10-C3 A4-B10-C4 A4-B10-C5 A4-B10-C6
A4-B10-C7 A4-B10-C8 A4-B10-C9 A4-B10-C 10 A4-B10-C 11 A4-B10-C 12
A4-B10-Cl 3 A4-B10-C 14 A4-B10-C 15 A4-B10-C 16 A4-B10-C 17 A4-B10-C 18
A4-B10-C 19 A4-B10-C20 A4-B10-C21 A4-B10'C22 A4-B10-C23 A4-B10-C24
A4-B10-C25 A4-B10-C26 A4-B10-C27 A4-B10-C28 A4-B 10-C29 A4-B10-C30
A4-B10-C31 A4-B10-C32 A4-B10-C33 A4-B10-C34 A4-B10-C35 A4-B10-C36
A4-B10-C37 A4-B10-C38 A4-B10-C39 A4-B10-C40 A4-B10-C41 A4-B10-C42
A4-B10-C43 A4-B10-C44 A4-B10-C45 A4-B10-C46 A4-B10-C47 A4-B10-C48
A4-B10-C49 A4-B10-C50 A4-B10-C51 A4-B10-C52 A4-B10-C53 A4-B10-C54
A4-B10-C55 A4-B10-C56 A4-B10-C57 A4-B10-C58 A4-B10-C59 A4-B10-C60
A4-B10-C61 A4-B10-C62 A4-B10-C63 A4-B10-C64 A4-B10-C65 A4-B10-C66
A4-B10-C67 A4-B10-C68 A4-B10-C69 A4-B10-C70 A4-B10-C71 A4-B10-C72
A4-B10-C73 A4-B10-C74 A4-B10-C75 A4-B10-C76 A4-B10-C77 A4-B10-C78
A4-B10-C79 A4-B10-C80 A4-B10-C81 A4-B10-C82 A4-B10-C83 A4-B10-C84

A4-B10-C85 A4-B10-C86 A4-B10-C87 A4-B10-C88 A4-B10-C89 A4-B10-C90
A4-B10-C91 A4-B10-C92 A4-B10-C93 A4-B10-C94 A4-B10-C95 A4-BI0-C96
A4-B10-C97 A4-B10-C98 A4-B10-C99 A4-B10-C100 A4-B10-C101 A4-B10-C102
A4-B10-C103 A4-B10-C104 A4-B10-C105 A4-B10-C106 A4-B10-C107 A4-B10-C108
A4-BI0-C109 A4-B10-Cn0 A4-B10-C111 A4-B10-C112 A4-B10-C1I3 A4-B10-CI14
A4-B10-C115 A4-B10-Cn6 A4-B10-C117 A4-B10-Cn8 A4-B10-C119 A4-BI0-C120
A4-B10-C121 A4-B10-C122 A4-B10-C123 A4-B10-C124 A4-B10-C125 A4-B10-C126
A4-B10-C127 A4-B10-C128 A4-B10-C129 A4-B10-C130 A4-B10-C131 A4-B10-C132
A4-B10-C133 A4-B10-C134 A4-B10-C135 A4-B10-C136 A4-B10-C137 A4-B10-C138
A4-B10-C139 A4-B10-C140 BLANK BLANK BLANK BLANK
A4-B11-C1 A4-B11-C2 A4-B11-C3 A4-Bn-C4 A4-B11-C5 A4-B11-C6
A4-B11-C7 A4-Bn-C8 A4-B11-C9 A4-B11-C10 A4-B11-CI1 A4-B11-C12
A4-B11-C13 A4-B11-C14 A4-B11-C15 A4-B11-C16 A4-B11-C17 A4-B11-C18
A4-B11-C19 A4-B11-C20 A4-Bn-C21 A4-B1I-C22 A4-B11-C23 A4-B11-C24
A4-BI1-C25 A4-Bn-C26 A4-B11-C27 A4-B11-C28 A4-B11-C29 A4-B]l-C30
A4-BI1-C31 A4-B11-C32 A4-B11-C33 A4-B11-C34 A4-B11-C35 A4-B1I-C36
A4-B11-C37 A4-B11-C38 A4-B11-C39 A4-B11-C40 A4-B11-C41 A4-B11-C42
A4-B11-C43 A4-B11-C44 A4-B11-C45 A4-B11-C46 A4-B11-C47 A4-B11-048
A4-B1I-C49 A4-B11-C50 A4-B11-C51 A4-B11-C52 A4-B11-C53 A4-B11-C54
A4-B11-C55 A4-BI1-C56 A4-B11-C57 A4-B11-C58 A4-B11-C59 A4-B11-C60
A4-Bn-C61 A4-B11-C62 A4-B11-C63 A4-B11-C64 A4-B11-C65 A4-B11-C66
A4-B11-C67 A4-B11-C68 A4-B11-C69 A4-B11-C70 A4-B11-C71 A4-B11-C72
A4-B11-C73 A4-B11-C74 A4-B11-C75 A4-B11-C76 A4-B11-C77 A4-B11-C78
A4-B11-C79 A4-B11-C80 A4-B11-C81 A4-B11-C82 A4-B11-C83 A4-B11-C84
A4-B11-C85 A4-B11-C86 A4-B11-C87 A4-B11-C88 A4-B11-C89 A4-B11-C90
A4-B11-C91 A4-B11-C92 A4-B11-C93 A4-B11-C94 A4-B11-C95 A4-B11-C96
A4-B11-C97 A4-B11-C98 A4-B11-C99 A4-B11-C100 A4-B11-C101 A4-B11-C102
A4-B11-C103 A4-B11-C104 A4-B11-C105 A4-B11-C106 A4-B11-CI07 A4-B11-C108
A4-B11-C109 A4-B11-C110 A4-B11-C111 A4-B11-C112 A4-B11-C113 A4-B11-C114
A4-B1I-C115 A4-B11-C116 A4-B11-C117 A4-B11-C118 A4-B11-C119 A4-B11-C120
A4-B11-C121 A4-B11-C122 A4-B11-C123 A4-B11-C124 A4-B11-C125 A4-B11-C126
A4-B11-C127 A4-B11-C128 A4-B11-C129 A4-B11-C130 A4-B11-C131 A4-B11-C132
A4-B11-C133 A4-B11-C134 A4-B11-C135 A4-B11-C136 A4-B11-C137 A4-B11-C138
A4-B11-C139 A4-B11-C140 BLANK BLANK BLANK BLANK
A4-B12-C1 A4-B12-C2 A4-B12-C3 A4-B12-C4 A4-B12-C5 A4-B12-C6
A4-B12-C7 A4-BI2-C8 A4-B12-C9 A4-B12-C10 A4-B12-C11 A4-B12-C12
A4-B12-C13 A4-B12-C14 A4-B12-C15 A4-B12-C16 A4-B12-C17 A4-B12-C18

A4-B12-C19 A4-B12-C20 A4-B12-C21 A4-B12-C22 A4-B12-C23 A4-B12-C24
A4-B12-C25 A4-B12-C26 A4-B12-C27 A4-B12-C28 A4-B 12-C29 A4-B12-C30
A4-B12-C31 A4-B12-C32 A4-B12-C33 A4-B12-C34 A4-B12-C35 A4-B12-C36
A4-B12-C37 A4-B12-C38 A4-B12-C39 A4-B12-C40 A4-B12-C41 A4-B12-C42
A4-B12-C43 A4-B12-C44 A4-B12-C45 A4-B12-C46 A4-B12-C47 A4-B12-C48
A4-B12-C49 A4-B12-C50 A4-B12-C51 A4-B12-C52 A4-B12-C53 A4-B12-C54
A4-B12-C55 A4-B12-C56 A4-B12-C57 A4-B12-C58 A4-B12-C59 A4-B12-C60
A4-B12-C61 A4-B12-C62 A4-B12-C63 A4-B12-C64 A4-B12-C65 A4-B12-C66
A4-B12'C67 A4-B12-C68 A4-B12-C69 A4-B12-C70 A4-B12-C71 A4-B12-C72
A4'B 12-C73 A4-B12-C74 A4-B12-C75 A4-B12-C76 A4-B12-C77 A4-B12-C78
A4-B12-C79 A4-B12-C80 A4-B 12-C81 A4-B12-C82 A4-B12-C83 A4-B12-C84
A4-B12-C85 A4-B12-C86 A4-B12-C87 A4-B12-C88 A4-B12-C89 A4-B12-C90
A4-B12-C91 A4-B12-C92 A4-B12-C93 A4-B12-C94 A4-B12-C95 A4-B12-C96
A4-B12-C97 A4-B12-C98 A4-B12-C99 A4-B12-C 100 A4-B12-C 101 A4-B12-C 102
A4-B12-C 103 A4-B12-C 104 A4-B12-C 105 A4-B12-C 106 A4-B12-C 107 A4-B12-C 108
A4-B12-C109 A4-B12-C110 A4-B12-C111 A4-B12-C112 A4-B12-C113 A4'B12-C114
A4-B12-C 115 A4-B12-C 116 A4-B12-C 117 A4-B12-C 118 A4-B12-C 119 A4-B12-C 120
A4.B 12-C 121 A4-B12-C 122 A4-B12-C 123 A4-B12-C 124 A4-B12-C 125 A4-B12-C 126
A4-B12-C 127 A4-B12-C 128 A4-B12-C 129 A4-B12-C 130 A4-B12-C 131 A4-B12-C 132
A4-B12-C133 A4-B12-C134 A4-B12-C135 A4-B12-C136 A4-B12-C137 A4-B12-C138
A4-B12-C 139 A4-B12-C 140 BLANK BLANK BLANK BLANK
A4-B13-C1 A4-B13-C2 A4-B13-C3 A4-B13-C4 A4-B13-C5 A4-B13-C6
A4-B13-C7 A4-B13-C8 A4-B13-C9 A4-B13-C10 A4-B13-CI1 A4-B13-C12
A4-B13-C13 A4-B13-CI4 A4-B13-C15 A4-B13-C16 A4-B13-C17 A4-B13-C18
A4-B13-C19 A4-B13-C20 A4-B13-C21 A4-B13-C22 A4-B13-C23 A4-B13-C24
A4-B13-C25 A4-B13-C26 A4-B13-C27 A4-B13-C28 A4-B13-C29 A4-B13-C30
A4-B13-C31 A4-B13-C32 A4-B13-C33 A4-B13-C34 A4-B13-C35 A4-B13-C36
A4-BI3-C37 A4-B13-C38 A4-BI3-C39 A4-B13-C40 A4-B13-C41 A4-B13-C42
A4-B13-C43 A4-B13-C44 A4-B13-C45 A4-B13-C46 A4-B13-C47 A4-B13-C48
A4-B13-C49 A4-B13-C50 A4-B13-C51 A4-B13-C52 A4-B13-C53 A4-B13-C54
A4-B13-C55 A4-B13-C56 A4-B13-C57 A4-B13-C58 A4-B13-C59 A4-B13-C60
A4-B13-C61 A4-B13-C62 A4-B13-C63 A4-B13-C64 A4-B13-C65 A4-B13-C66
A4-B13-C67 A4-B13-C68 A4-B13-C69 A4-B13-C70 A4-B13-C71 A4-B13-C72
A4-B13-C73 A4-B13-C74 A4-B13-C75 A4-B13-C76 A4-B13-C77 A4-B13-C78
A4-B13-C79 A4-B13-C80 A4-B13-C81 A4-B13-C82 A4-B13-C83 A4-B13-C84
A4-B13-C85 A4-B13-C86 A4-B13-C87 A4-B13-C88 A4-B13-C89 A4-B13-C90
A4-B 13-C91 A4-B13-C92 A4-B13-C93 A4-B13-C94 A4-B13-C95 A4-B13-C96

A4.B 13-C97 A4-B13-C98 A4-B13-C99 A4-B13-C100 A4-B13-C101 A4-B13-C i 02
A4-B13-C103 A4-B13-C104 A4-B13-C105 A4-B13-C106 A4-B13-C107 A4-B13-C108
A4-B13-C109 A4-B13-CI10 A4-B13-C111 A4-B13-C112 A4-B13-C113 A4-B13-C114
A4-BI3-C1I5 A4-B13-C1I6 A4-B13-C117 A4-BI3-C118 A4-B13-CI19 A4-B13-C120
A4-B13-C121 A4-B13-C122 A4-B13-C123 A4'B13-C124 A4-B13-C125 A4-B13-C126
A4-B13-C]27 A4-B13-C128 A4-B13-C129 A4-B13-C130 A4-B13-C131 A4-B13-C132
A4-BI3-CI33 A4-BI3-C134 A4-B13-C135 A4-B13-C136 A4-B13-C137 A4-B13-C138
A4-B13-C139 A4-B13-C140 BLANK BLANK BLANK BLANK
A5-B1 -C1 A5-B1 -C2 A5-B1 -C3 A5-B1 -C4 A5-BI -C5 A5-B1 -C6
A5-BI -CI A5-B1 -C8 A5-B1 -C9 A5-B1 -C10 A5-B NC11 A5-B1 -C12
A5-BKC13 A5-BI-CI4 A5-BNC15 A5-B1-C16 AS-BNCl? A5-B1-C18
A5-B1 -C19 A5-B1-C20 A5-B1 -C21 A5-B1-C22 A5-B1-C23 A5-B1-C24
A5-B1-C25 A5-B1-C26 A5-B1-C27 A5-B1-C28 A5-B1-C29 A5-B1-C30
A5-BI -CZ1 A5-B1-C32 A5-B1-C33 A5-BI-C34 A5-B1-C35 A5-B1-C36
A5-B1-C37 A5-B1-C38 A5-B1-C39 A5-B1-C40 A5-BI-C4I A5-BI-C42
A5-B1-C43 A5-B1-C44 A5-B1-C45 A5-B1-C46 A5-B1-C47 A5-B1-C48
A5-B1-C49 A5-B1-C50 A5-B1-C51 A5-B1-C52 A5-BKC53 A5-B1-C54
A5-B1-C55 A5-B1-C56 A5-B1-C57 A5-BI-C58 A5-BNC59 A5-B1-C60
A5-B1-C61 A5-B1-C62 A5-B1-C63 A5-B1-C64 A5-B1-C65 A5-B1-C66
A5-B1-C67 A5-B1-C68 A5-B1-C69 A5-B1-C70 A5-B1 -C71 A5-B1-C72
A5-B1-C73 A5-BI-C74 A5-B1-C75 A5-BI-C76 A5-B1-C77 A5-BI-C78
A5-B1-C79 A5-B1-C80 A5-B1-C81 A5-B1-C82 A5-BI-C83 A5-B1-C84
A5-B1-C85 A5-B1-C86 A5-B1-C87 A5-B1-C88 A5-B1-C89 A5-B1-C90
A5-B1 -C9 i A5-B1-C92 A5-BI-C93 A5-B1-C94 A5-B1-C95 A5-B1-C96
A5-B1-C97 A5-B1-C98 A5-B1-C99 A5-B1-C100 A5-BI-CI01 A5-B1-C102
A5-B1-C103 A5-B1-C104 A5-B1-C105 A5-B1-C106 A5-B1-C107 A5-B1-C108
A5-B1-C109 A5-B1-C] 10 A5-B1-C111 A5-B1-C112 A5-B1-C113 A5-B1-C114
A5-B1-C115 A5-B1-C116 A5-B1-C117 A5-BI-C118 A5-B1-C119 A5-B1-C120
A5-B1-C121 A5-B1-C122 A5-B1-C123 A5-B1-C124 A5-B1-C125 A5-B1-C126
A5-B1-C127 A5-B1-C128 A5-B1-C129 A5-BI-C130 A5-B1-C131 A5-B1-C132
A5-B1-C133 A5-BI-CI34 A5-B1-C135 A5-B1-C136 A5-B1-C137 A5-B1-C138
A5-B1-C139 A5-B1-C140 BLANK BLANK BLANK BLANK
A5-B2-CI A5-B2-C2 A5-B2-C3 A5-B2-C4 A5-B2-C5 A5-B2-C6
A5-B2-C7 A5-B2-C8 A5-B2-C9 A5-B2-CI0 A5-B2-Cn A5-B2-C12
A5-B2-C13 A5-B2-C14 A5-B2-C15 A5-B2-C16 A5-B2-C17 A5-B2-C18
A5-B2-C19 A5-B2-C20 A5-B2-C21 A5-B2-C22 A5-B2-C23 A5-B2-C24
A5-B2-C25 A5-B2-C26 A5-B2-C27 A5-B2-C28 A5-B2-C29 A5-B2-C30

A5-B2-C31 A5-B2-C32 A5-B2-C33 A5-B2-C34 A5-B2-C35 A5-B2-C36
A5-B2-C37 A5-B2-C38 A5-B2-C39 A5-B2-C40 A5-B2-C41 A5-B2-C42
A5-B2-C43 A5-B2-C44 A5-B2-C45 A5-B2-C46 A5-B2-C47 A5-B2-C48
A5-B2-C49 A5-B2-C50 A5-B2-C51 A5-B2-C52 A5-B2-C53 A5-B2-C54
A5-B2-C55 A5-B2-C56 A5-B2-C57 A5-B2-C58 A5-B2-C59 A5-B2-C60
A5-B2-C61 A5-B2-C62 A5-B2-C63 A5-B2-C64 A5-B2-C65 A5-B2-C66
A5-B2-C67 A5-B2-C68 A5-B2-C69 A5-B2-C70 A5-B2-C71 A5-B2-C72
A5-B2-C73 A5-B2-C74 A5-B2-C75 A5-B2-C76 A5-B2-C77 A5-B2-C78
A5-B2-C79 A5-B2-C80 A5-B2-C81 A5-B2-C82 A5-B2-C83 A5-B2-C84
A5-B2-C85 A5-B2-C86 A5-B2-C87 A5-B2-C88 A5-B2-C89 A5-B2-C90
A5-B2-C91 A5-B2-C92 A5-B2-C93 A5-B2-C94 A5'B2-C95 A5-B2-C96
A5-B2-C97 A5-B2-C98 A5-B2-C99 A5-B2-C100 A5-B2-C101 A5-B2-C102
A5-B2-C103 A5-B2-C104 A5-B2-C105 A5-B2-C106 A5-B2-C107 A5-B2-C108
A5-B2-C109 A5-B2-C110 A5-B2-C111 A5-B2-C112 A5-B2-CI13 A5-B2-C114
A5-B2-C115 A5-B2-C116 A5-B2-C117 A5-B2-C118 A5-B2-C119 A5-B2-C120
A5-B2-C121 A5-B2-C122 A5-B2-C123 A5-B2-C124 A5-B2-C125 A5-B2-C126
A5-B2-C127 A5-B2-C128 A5-B2-C129 A5-B2-C130 A5-B2-C131 A5-B2-C132
A5-B2-C133 A5-B2-C134 A5-B2-C135 A5-B2-C136 A5-B2-C137 A5-B2-C138
A5-B2-C139 A5-B2-C140 BLANK BLANK BLANK BLANK
A5-B3-C1 A5-B3-C2 A5-B3-C3 A5-B3-C4 A5-B3-C5 A5-B3'C6
A5-B3-C7 A5-B3-C8 A5-B3-C9 A5-B3-C10 A5-B3'C11 A5-B3-C12
A5-B3-C13 A5-B3-C14 A5-B3-C15 A5-B3-C16 A5-B3-C17 A5-B3-C18
A5-B3-C19 A5-B3-C20 A5-B3-C21 A5-B3-C22 A5-B3-C23 A5-B3-C24
A5-B3-C25 A5-B3-C26 A5-B3-C27 A5-B3-C28 A5-B3-C29 A5-B3-C30
A5-B3-C31 A5-B3-C32 A5-B3-C33 A5-B3-C34 A5-B3-C35 A5-B3-C36
A5-B3-C37 A5-B3-C38 A5-B3-C39 A5-B3-C40 A5-B3-C41 A5-B3-C42
A5-B3-C43 A5-B3-C44 A5-B3-C45 A5-B3-C46 A5-B3-C47 A5-B3-C48
A5-B3-C49 A5-B3-C50 A5-B3-C51 A5-B3-C52 A5-B3-C53 A5-B3-C54
A5-B3-C55 A5-B3-C56 A5-B3-C57 A5-B3-C58 A5-B3-C59 A5-B3-C60
A5-B3-C61 A5-B3-C62 A5'B3-C63 A5-B3-C64 A5-B3-C65 A5-B3-C66
A5-B3-C67 A5-B3'C68 A5-B3-C69 A5-B3-C70 A5-B3-C71 A5-B3-C72
A5-B3-C73 A5-B3-C74 A5-B3-C75 A5-B3-C76 A5-B3-C77 A5-B3-C78
A5-B3-C79 A5-B3-C80 A5-B3-C81 A5-B3-C82 A5-B3-C83 A5-B3-C84
A5-B3-C85 A5-B3-C86 A5-B3-C87 A5-B3-C88 A5-B3-C89 A5-B3-C90
A5-B3-C91 A5-B3-C92 A5-B3-C93 A5-B3'C94 A5-B3-C95 A5-B3-C96
A5-B3-C97 A5-B3-C98 A5-B3-C99 A5-B3-C100 A5-B3-CI01 A5-B3-C102
A5-B3-C103 A5-B3-C104 A5-B3-C105 A5-B3-C106 A5-B3-C107 A5-B3-C108

A5-B3-C109 A5-B3-C110 A5-B3-C111 A5-B3.C112 A5-B3-C113 AS-BB-Cl 14
A5-B3-C115 A5-B3-C116 A5-B3.C117 A5-B3-C118 A5-B3-C119 A5-B3-C120
A5.B3-C121 A5-B3-C122 A5-B3-C123 A5-B3-C124 A5-B3-C125 A5-B3-C126
A5-B3-C127 A5-B3-C128 A5-B3.C129 A5-B3-C130 A5-B3-C131 A5-B3-C132
A5-B3-CI33 A5-B3-C134 A5-B3-C135 A5-B3-C136 A5-B3-C137 A5-B3-C138
A5-B3-C139 A5-B3-C140 BLANK BLANK BLANK BLANK
A5-B4-C1 A5-B4-C2 A5-B4-C3 A5-B4-C4 A5-B4-C5 A5-B4-C6
A5-B4-C7 A5-B4.C8 A5-B4-C9 A5-B4-C10 A5-B4-C11 A5-B4-C12
A5-B4-C13 A5-B4.C 14 A5-B4-C15 A5-B4-C16 A5-B4-C17 A5-B4-C18
A5-B4-C19 A5-B4-C20 A5-B4-C21 A5-B4-C22 A5-B4-C23 A5-B4-C24
A5-B4-C25 A5-B4-C26 A5-B4-C27 A5-B4-C28 A5-B4-C29 A5-B4-C30
A5-B4-C31 A5-B4'C32 A5-B4-C33 A5-B4-C34 A5-B4-C35 A5-B4-C36
A5-B4-C37 A5-B4-C38 A5-B4-C39 A5-B4-C40 A5-B4-C41 A5-B4-C42
A5-B4-C43 A5-B4-C44 A5-B4-C45 A5-B4-C46 A5-B4-C47 A5-B4-C48
A5-B4-C49 A5-B4-C50 A5-B4-C51 A5-B4-C52 A5-B4-C53 A5-B4-C54
A5-B4-C55 A5-B4-C56 A5-B4-C57 A5-B4-C58 A5-B4-C59 A5-B4-C60
A5-B4-C61 A5-B4-C62 A5-B4-C63 A5-B4-C64 A5-B4-C65 A5-B4-C66
A5-B4-C67 A5-B4-C68 A5-B4-C69 A5-B4-C70 A5-B4-C71 A5-B4-C72
A5-B4-C73 A5-B4-C74 A5-B4-C75 A5-B4-C76 A5-B4'C77 A5-B4-C78
A5-B4-C79 A5-B4-C80 A5-B4-C81 A5-B4-C82 A5-B4-C83 A5-B4-C84
A5-B4-C85 A5-B4-C86 A5-B4-C87 A5-B4-C88 A5-B4-C89 A5-B4-C90
A5-B4-C91 A5-B4-C92 A5-B4-C93 A5-B4-C94 A5-B4-C95 A5-B4-C96
A5-B4-C97 A5-B4-C98 A5-B4-C99 A5-B4-C100 A5-B4-C101 A5-B4-C102
A5-B4-C103 A5-B4-C104 A5-B4-C105 A5-B4-C106 A5-B4-C107 A5-B4-C108
A5-B4-C109 A5-B4-C110 A5-B4-C111 A5-B4-C112 A5-B4-C113 A5-B4-C114
A5-B4-C115 A5-B4-C116 A5-B4-C117 A5-B4-C118 A5-B4-C119 A5-B4-C120
A5-B4-C 121 A5-B4-C122 A5-B4-C123 A5-B4-C124 A5-B4-C125 A5-B4-C 126
A5-B4-C127 A5-B4-C128 A5-B4-C129 A5-B4-C130 A5-B4-C131 A5-B4-C132
A5-B4-C133 A5-B4-C134 A5-B4-C135 A5-B4-C136 A5-B4-C137 A5-B4-C138
A5-B4-C139 A5-B4-C140 BLANK BLANK BLANK BLANK
A5-B5-C1 A5-B5-C2 A5-B5-C3 A5-B5-C4 A5-B5-C5 A5-B5-C6
A5-B5-C7 A5-B5-C8 A5-B5-C9 A5-B5-C10 A5-B5-C11 A5-B5-C12
A5-B5-C13 A5-B5-C14 A5-B5-C15 A5-B5-C16 A5-B5-C17 A5-B5-C18
A5-B5-C19 A5-B5-C20 A5-B5-C21 A5-B5-C22 A5-B5-C23 A5-B5-C24
A5-B5-C25 A5-B5-C26 A5-B5-C27 A5-B5-C28 A5-B5-C29 A5-B5-C30
A5-B5-C31 A5-B5-C32 A5-B5-C33 A5-B5-C34 A5-B5-C35 A5-B5-C36
A5-B5-C37 A5-B5-C38 A5-B5-C39 A5-B5-C40 A5-B5-C4] A5-B5-C42

A5-B5-C43 A5-B5-C44 A5-B5-C45 A5-B5-C46 A5-B5-C47 A5-B5-C48
A5-B5-C49 A5-B5-C50 A5-B5-C51 A5-B5-C52 A5-B5-C53 A5-B5-C54
A5-B5-C55 A5-B5-C56 A5-B5-C57 A5-B5-C58 A5-B5-C59 A5-B5-C60
A5-B5-C61 A5-B5-C62 A5-B5-C63 A5-B5-C64 A5-B5-C65 A5-B5-C66
A5-B5-C67 A5-B5-C68 A5-B5-C69 A5-B5-C70 A5-B5-C71 A5-B5-C72
A5-B5-C73 A5-B5-C74 A5-B5-C75 A5-B5-C76 A5-B5-C77 A5-B5-C78
A5-B5-C79 A5-B5-C80 A5-B5-C81 A5-B5-C82 A5-B5-C83 A5-B5-C84
A5-B5-C85 A5-B5-C86 A5-B5-C87 A5-B5-C88 A5-B5-C89 A5-B5-C90
A5-B5-C91 A5-B5-C92 A5-B5-C93 A5-B5-C94 A5-B5-C95 A5-B5-C96
A5-B5-C97 A5-B5-C98 A5-B5-C99 A5-B5-C100 A5-B5-C101 A5-B5-C102
A5-B5-C103 A5-B5-C104 A5-B5-C105 A5-B5-C106 A5-B5-C107 A5-B5-C108
A5-B5-C109 A5-B5-C110 A5-B5-Cni A5-B5-C112 A5-B5-C113 A5-B5-C114
A5-B5-C115 A5-B5-C116 A5-B5-C117 A5-B5-C118 A5-B5-C119 A5-B5-C120
A5-B5-C12I A5-B5-C122 A5-B5-C123 A5-B5-C124 A5-B5-C125 A5-B5-C126
A5-B5-CI27 A5-B5-C128 A5-B5-C129 A5-B5-C130 A5-B5-C131 A5-B5-C132
A5-B5-C133 A5-B5-C134 A5-B5-C135 A5-B5-C136 A5-B5-C137 A5-B5-C138
A5-B5-C139 A5-B5-C140 BLANK BLANK BLANK BLANK
A5-B6-C1 A5-B6-C2 A5-B6-C3 A5-B6-C4 A5-B6-C5 A5-B6-C6
A5-B6-C7 A5-B6-C8 A5-B6-C9 A5-B6-C10 A5-B6-CI 1 A5-B6-CI2
A5-B6-C13 A5-B6-C14 A5-B6-C15 A5-B6-C16 A5-B6-CI7 A5-B6-C18
A5-B6-C19 A5-B6-C20 A5-B6-C21 A5-B6-C22 A5-B6-C23 A5-B6-C24
A5-B6-C25 A5-B6-C26 A5-B6-C27 A5-B6-C28 A5-B6-C29 A5-B6-C30
A5-B6-C31 A5-B6-C32 A5-B6-C33 A5-B6-C34 A5-B6-C35 A5-B6-C36
A5-B6-C37 A5-B6-C38 A5-B6-C39 A5-B6-C40 A5-B6-C41 A5-B6-C42
A5-B6-C43 A5-B6-C44 A5-B6-C45 A5-B6-C46 A5-B6-C47 A5-B6-C48
A5-B6-C49 A5-B6-C50 A5-B6-C51 A5-B6-C52 A5-B6-C53 A5-B6-C54
A5-B6-C55 A5-B6-C56 A5-B6-C57 A5-B6-C58 A5-B6-C59 A5-B6-C60
A5-B6-C61 A5-B6-C62 A5-B6-C63 A5-B6-C64 A5-B6-C65 A5-B6-C66
A5-B6-C67 A5-B6-C68 A5-B6-C69 A5-B6-C70 A5-B6-C71 A5-B6-C72
A5-B6-C73 A5-B6-C74 A5-B6-C75 A5-B6-C76 A5-B6-C77 A5-B6-C78
A5-B6-C79 A5-B6-C80 A5-B6-C81 A5-B6-C82 A5-B6-C83 A5-B6-C84
A5-B6-C85 A5-B6-C86 A5-B6-C87 A5-B6-C88 A5-B6-C89 A5-B6-C90
A5-B6-C91 A5-B6-C92 A5-B6-C93 A5-B6-C94 A5-B6-C95 A5-B6-C96
A5-B6-C97 A5-B6-C98 A5-B6-C99 A5-B6-C100 A5-B6-C101 A5-B6-C102
A5-B6-C103 A5-B6-C104 A5-B6-C105 A5-B6-C106 A5-B6-C107 A5-B6-C108
A5-B6-C109 A5-B6-C110 A5-B6-C111 A5-B6-C112 A5-B6-C113 A5-B6-C114
A5-B6-C115 A5-B6-C116 A5-B6-C117 A5-B6-C118 A5-B6-C119 A5-B6-C120

A5-B6-C121 A5-B6-C122 A5-B6-C123 A5-B6-C124 A5-B6-C125 A5-B6-C126
A5-B6-C127 A5-B6-C128 A5-B6-C129 A5-B6-C130 A5-B6-C131 A5-B6-CI32
A5-B6-C133 A5-B6-C134 A5-B6-C135 A5-B6-C136 A5-B6-CI37 A5-B6-C138
A5-B6-C139 A5-B6-C140 BLANK BLANK BLANK BLANK
A5-B7-C1 A5-B7-C2 A5-B7-C3 A5-B7-C4 A5-B7-C5 A5-B7-C6
A5-B7-C7 A5-B7-C8 A5-B7-C9 A5-B7-C10 A5-B7-C11 A5-B7-C12
A5-B7-C13 A5-B7-C14 A5-B7-C15 A5-B7-C16 A5-B7-CI7 A5-B7-C18
A5-B7-C19 A5-B7-C20 A5-B7-C2I A5-B7-C22 A5-B7-C23 A5-B7-C24
A5-B7-C25 A5-B7-C26 A5-B7-C27 A5-B7-C28 A5-B7-C29 A5-B7-C30
A5-B7-C31 A5-B7-C32 A5-B7-C33 A5-B7-C34 A5-B7-C35 A5-B7-C36
A5-B7-C37 A5-B7-C38 A5-B7-C39 A5-B7-C40 A5-B7-C41 A5-B7-C42
A5-B7-C43 A5-B7-C44 A5-B7-C45 A5-B7-C46 A5-B7-C47 A5-B7-C48
A5-B7-C49 A5-B7-C50 A5-B7-C51 A5-B7-C52 A5-B7-C53 A5-B7-C54
A5-B7-C55 A5-B7-C56 A5-B7-C57 A5-B7-C58 A5-B7-C59 A5-B7-C60
A5-B7-C61 A5-B7-C62 A5-B7-C63 A5-B7-C64 A5-B7-C65 A5-B7-C66
A5-B7-C67 A5-B7-C68 A5-B7-C69 A5-B7-C70 A5-B7-C71 A5-B7-C72
A5-B7-C73 A5-B7-C74 A5-B7-C75 A5-B7-C76 A5-B7-C77 A5-B7-C78
A5-B7-C79 A5-B7-C80 A5-B7-C81 A5-B7-C82 A5-B7-C83 A5-B7-C84
A5-B7-C85 A5-B7-C86 A5-B7-C87 A5-B7-C88 A5-B7-C89 A5-B7-C90
A5-B7-C91 A5-B7-C92 A5-B7-C93 A5-B7-C94 A5-B7-C95 A5-B7-C96
A5-B7-C97 A5-B7-C98 A5-B7-C99 A5-B7-C100 A5-B7-C101 A5-B7-C102
A5-B7-C103 A5-B7-C104 A5-B7-C105 A5-B7-C106 A5-B7-C107 A5-B7-C108
A5-B7-C109 A5-B7-C110 A5-B7-C111 A5-B7-C112 A5-B7-C113 A5-B7-C114
A5-B7-C115 A5-B7-CI16 A5-B7-C117 A5-B7-C118 A5-B7-C119 A5-B7-C120
A5-B7-C121 A5-B7-C122 A5-B7-C123 A5-B7-C124 A5-B7-C125 A5-B7-C126
A5-B7-C127 A5-B7-C128 A5-B7-C129 A5-B7-C130 A5-B7-C131 A5-B7-CI32
A5-B7-C133 A5-B7-C134 A5-B7-C135 A5-B7-C136 A5-B7-C137 A5-B7-C138
A5-B7-C139 A5-B7-C140 BLANK BLANK BLANK BLANK
A5-B8-C1 A5-B8-C2 A5-B8-C3 A5-B8-C4 A5-B8-C5 A5-B8-C6
A5-B8-C7 A5-B8-C8 A5-B8-C9 A5-B8-C10 A5-B8-C11 A5-B8-C12
A5-B8-C13 A5-B8-C14 A5-B8-C15 A5-B8-C16 A5-B8-C17 A5-B8-C18
A5-B8-C19 A5-B8-C20 A5-B8-C21 A5-B8-C22 A5-B8-C23 A5-B8-C24
A5-B8-C25 A5-B8-C26 A5-B8-C27 A5-B8-C28 A5-B8-C29 A5-B8-C30
A5-B8-C31 A5-B8-C32 A5-B8-C33 A5-B8-C34 A5-B8-C35 A5-B8-C36
A5-B8-C37 A5-B8-C38 A5-B8-C39 A5-B8-C40 A5-B8-C41 A5-B8-C42
A5-B8-C43 A5-B8-C44 A5-B8-C45 A5-B8-C46 A5-B8-C47 A5-B8-C48
A5-B8-C49 A5-B8-C50 A5-B8-C51 A5-B8-C52 A5-B8-C53 A5-B8-C54

A5-B8'C55 A5-B8-C56 A5-B8-C57 A5-B8-C58 A5-B8-C59 A5-B8-C60
A5-B8-C61 A5-B8-C62 A5-B8-C63 A5-B8-C64 A5-B8-C65 A5-B8-C66
A5-B8-C67 A5-B8-C68 A5-B8-C69 AS--BS-CVO A5-B8-C71 A5-B8-C72
A5-B8-C73 A5-B8-C74 A5-B8-C75 A5-B8-C76 A5-B8-C77 A5-B8-C78
A5-B8-C79 A5-B8-C80 A5-B8-C81 A5-B8-C82 A5-B8-C83 A5-B8-C84
A5-B8-C85 A5-B8-C86 A5-B8-C87 A5-B8-C88 A5-B8-C89 A5-B8-C90
A5-B8-C91 A5-B8-C92 A5-B8-C93 A5-B8-C94 A5-B8-C95 A5-B8-C96
A5-B8-C97 A5-B8-C98 A5-B8-C99 A5-B8-C100 A5-B8-C101 A5-B8-C102
A5-B8-C103 A5-B8-C104 A5-B8-C105 A5-B8-C106 A5-B8-CI07 A5-B8-C108
A5-B8-C109 A5-B8-C110 A5-B8-C111 A5-B8-C112 A5-B8-C113 A5-B8-C114
A5-B8'C115 A5-B8-C116 A5-B8-C117 A5-B8-C118 A5-B8-C119 A5-B8-C120
A5-B8-C121 A5-B8-C122 A5-B8-C123 A5-B8-C124 A5-B8-C125 A5-B8-C126
A5-B8-C127 A5-B8-C128 A5-B8'C129 A5-B8-C130 A5-B8-C13I A5-B8-C132
A5-B8-C133 A5-B8-C134 A5-B8-C135 A5-B8-C136 A5-B8-C137 A5-B8-C138
A5-B8-C139 A5-B8-C140 BLANK BLANK BLANK BLANK
A5-B9-C1 A5-B9-C2 A5-B9-C3 A5-B9-C4 A5-B9-C5 A5-B9-C6
A5-B9-C7 A5-B9-C8 A5-B9-C9 A5-B9-C10 A5-B9-C11 A5-B9-C12
A5-B9-C13 A5-B9-C14 A5-B9-C15 A5-B9-C16 A5-B9-C17 A5-B9-C18
A5-B9-C19 A5-B9-C20 A5-B9-C21 A5-B9-C22 A5-B9-C23 A5-B9-C24
A5-B9-C25 A5-B9-C26 A5-B9-C27 A5-B9-C28 A5-B9-C29 A5-B9-C30
A5-B9-C31 A5-B9-C32 A5-B9-C33 A5-B9-C34 A5-B9-C35 A5-B9-C36
A5'B9-C37 A5-B9-C38 A5-B9-C39 A5-B9-C40 A5-B9-C41 A5-B9-C42
A5-B9-C43 A5-B9-C44 A5-B9-C45 A5-B9-C46 A5-B9-C47 A5-B9-C48
A5-B9-C49 A5-B9-C50 A5-B9-C51 A5-B9-C52 A5-B9-C53 A5-B9-C54
A5-B9-C55 A5-B9-C56 A5-B9-C57 A5-B9-C58 A5-B9-C59 A5-B9-C60
A5-B9-C61 A5-B9-C62 A5-B9-C63 A5-B9-C64 A5-B9-C65 A5-B9-C66
A5-B9-C67 A5-B9-C68 A5-B9-C69 A5-B9-C70 A5-B9-C71 A5-B9-C72
A5-B9-C73 A5-B9-C74 A5-B9-C75 A5-B9-C76 A5-B9-C77 A5-B9-C78
A5-B9-C79 A5-B9-C80 A5-B9-C81 A5-B9-C82 A5-B9-C83 A5-B9-C84
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A5-B9-C103 A5-B9-C104 A5-B9-C105 A5-B9-C106 A5-B9-C107 A5-B9-C108
A5-B9-C109 A5-B9-C110 A5-B9'C111 A5-B9-C112 A5-B9-C113 A5-B9-C114
A5-B9-C115 A5-B9-C116 A5-B9-C117 A5-B9-C118 A5-B9-C119 A5-B9-C120
A5-B9-C121 A5-B9-C122 A5 -B9-C123 A5-B9-C124 A5-B9-C125 A5-B9-C126
A5-B9-C127 A5-B9-C128 A5-B9-C129 A5-B9-C130 A5-B9-C131 A5-B9-C132

A5-B9-C133 A5-B9-C134 A5-B9-C135 A5-B9-C136 A5-B9-C137 A5-B9-C138
A5-B9-C139 A5-B9-C140 BLANK BLANK BLANK BLANK
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A5-B10-C127 A5-B10-C128 A5-B10-C129 A5-B10-C130 A5-B10-C131 A5-B10-C132
A5-B10-C133 A5-B10-C134 A5-B10-C135 A5-B10-C136 A5-B10-C137 A5-B10-CI38
A5-B10-C139 A5-B10-C140 BLANK BLANK BLANK BLANK
A5-B11-C1 A5-B11-C2 A5-B11-C3 A5-BI1-C4 A5-B11-C5 A5-B11-C6
A5-B11-C7 A5-B11-C8 A5-B11-C9 AS-BU-CIO A5-B11-C11 A5-B11-C12
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A5-B11-C61 A5-B11-C62 A5-B11-C63 A5-B11-C64 A5-B11-C65 A5-B11-066

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A5-B11-C127 A5-B11-C128 A5-B11-C129 A5-B11-C130 A5-B11-C131 A5-B11-C132
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A5-BI1-CI39 A5-B1I-C140 BLANK BLANK BLANK BLANK
A5-B12-C1 A5-B12-C2 A5-B12-C3 A5-B12-C4 A5-B12-C5 A5-BI2-C6
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A5-B12-C127 A5-B12-C128 A5-B12-C129 A5-BI2-C130 A5-B12-C131 A5-B12-C132
A5-B12-C133 A5-B12-C134 A5-B12-C135 A5-B12-C136 A5-B12-C137 A5-B12-C138
A5-B12-C139 A5-B12-C140 BLANK BLANK BLANK BLANK

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A5-B13-C 139 A5-B13-C 140 BLANK BLANK BLANK BLANK
A6-B1 -C1 A6-B1 -C2 A6-B1 -C3 A6-B1 -C4 A6-BI -C5 A6-B1 -C6
A6-B ] -C7 A6-B ] -C8 A6-B1 -C9 A6-B1 -C10 A6-B1 -C11 A6-B1 -C12
A6-B1-C13 A6-B1-C14 A6-B1-C15 A6-B1-C16 A6-B1-C17 A6-BI-C18
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A6-B1-C49 A6-B1-C50 A6-B1 -C51 A6-B1-C52 A6-B1-C53 A6-B1-C54
A6-B1-C55 A6-BI-C56 A6-B1-C57 A6-B ] -CSS - A6-B1-C59 A6-B1-C60
A6-B1 -C61 A6-B1-C62 A6-B1-C63 A6-B1-C64 A6-B1-C65 A6-B1-C66
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A6-B1 -C139 A6-B1 -C140 BLANK BLANK BLANK BLANK
A6-B2-C1 A6-B2-C2 A6-B2-C3 A6-B2-C4 A6-B2-C5 A6-B2-C6
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A6-B2-C97 A6-B2-C98 A6-B2-C99 A6-B2-C100 A6-B2-C101 A6-B2-C102
A6-B2-C103 A6-B2-C104 A6-B2-C105 A6-B2-C106 A6-B2-C107 A6-B2-C108
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A6-B2-C121 A6-B2-C122 A6-B2-C123 A6-B2-C124 A6-B2-C125 A6-B2-C126
A6-B2-C127 A6-B2-C128 A6-B2-C129 A6-B2-C130 A6-B2-C131 A6-B2-C132
A6-B2-C133 A6-B2-C134 A6-B2-C135 A6-B2-C136 A6-B2-C137 A6-B2-C138
A6-B2-C139 A6-B2-C140 BLANK BLANK BLANK BLANK
A6-B3-C1 A6-B3-C2 A6-B3-C3 A6-B3-C4 A6-B3-C5 A6-B3-C6
A6-B3-C7 A6-B3-C8 A6-B3-C9 A6-B3-C10 A6-B3-C11 A6-B3-C12

A6-B3-C13 A6-B3-C14 A6-B3-C15 A6-B3-C16 A6-B3-C17 A6-B3-C18
A6-B3-C19 A6-B3-C20 A6-B3-C21 A6-B3-C22 A6-B3-C23 A6-B3-C24
A6-B3-C25 A6-B3-C26 A6-B3-C27 A6-B3-C28 A6-B3-C29 A6-B3-C30
A6-B3-C31 A6-B3-C32 A6-B3-C33 A6-B3-C34 A6'B3-C35 A6-B3-C36
A6-B3-C37 A6-B3-C38 A6-B3~C39 A6-B3-C40 A6-B3-C41 A6-B3-C42
A6-B3-C43 A6-B3-C44 A6-B3-C45 A6-B3-C46 A6-B3-C47 A6-B3-C48
A6-B3-C49 A6-B3-C50 A6-B3-C51 A6-B3-C52 A6-B3-C53 A6-B3-C54
A6-B3-C55 A6-B3-C56 A6-B3-C57 A6-B3-C58 A6'B3-C59 A6-B3-C60
A6-B3-C6I A6-B3-C62 A6-B3-C63 A6'B3-C64 A6-B3-C65 A6-B3-C66
A6-B3-C67 A6-B3-C68 A6-B3-C69 A6-B3-C70 A6-B3-C71 A6-B3-C72
A6-B3-C73 A6-B3-C74 A6-B3-C75 A6-B3-C76 A6-B3-C77 A6-B3-C78
A6-B3-C79 A6-B3-C80 A6-B3'C8l A6-B3-C82 A6-B3-C83 A6-B3-C84
A6-B3-C85 A6-B3-C86 A6-B3-C87 A6-B3-C88 A6-B3-C89 A6-B3-C90
A6-B3-C91 A6-B3-C92 A6-B3-C93 A6-B3-C94 A6-B3-C95 A6-B3-C96
A6-B3-C97 A6-B3-C98 A6-B3'C99 A6-B3-C100 A6-B3-C101 A6-B3-C102
A6-B3-C103 A6-B3-CI04 A6-B3-C105 A6-B3-C106 A6-B3-C107 A6-B3-C108
A6-B3-C109 A6-B3-C110 A6-B3-C111 A6-B3-C112 A6-B3-C113 A6-B3-C114
A6-B3-C115 A6-B3-C116 A6-B3-C117 A6-B3-C118 A6-B3-C119 A6-B3-C120
A6-B3-C121 A6-B3-C122 A6-B3-C123 A6-B3-C124 A6-B3-C125 A6-B3-C126
A6-B3-C127 A6-B3-C128 A6-B3-C129 A6-B3-C130 A6-B3-C131 A6-B3-C132
A6-B3-C133 A6-B3-C134 A6-B3-C135 A6.B3-C136 A6-B3-C137 A6-B3-C138
A6-B3-C139 A6-B3-C140 BLANK BLANK BLANK BLANK
A6-B4-C1 A6-B4-C2 A6-B4-C3 A6-B4-C4 A6-B4-C5 A6-B4-C6
A6-B4-C7 A6-B4-C8 A6-B4-C9 A6-B4-C10 A6-B4-C11 A6-B4-C12
A6-B4-C13 A6-B4-C14 A6-B4-C15 A6-B4-C16 A6-B4-C17 A6-B4-C18
A6-B4-C19 A6-B4-C20 A6-B4-C21 A6-B4-C22 A6-B4-C23 A6-B4-C24
A6-B4-C25 A6-B4-C26 A6-B4-C27 A6-B4-C28 A6-B4-C29 A6-B4-C30
A6-B4-C31 A6-B4-C32 A6-B4-C33 A6--B4-C34 A6-B4-C35 A6-B4-C36
A6-B4-C37 A6-B4-C38 A6-B4-C39 A6-B4-C40 A6-B4-C41 A6-B4-C42
A6-B4-C43 A6-B4-C44 A6-B4-C45 A6-B4-C46 A6-B4-C47 A6-B4-C48
A6-B4-C49 A6-B4-C50 A6-B4-C51 A6-B4-C52 A6-B4-C53 A6-B4-C54
A6-B4-C55 A6-B4-C56 A6-B4-C57 A6-B4-C58 A6-B4-C59 A6-B4-C60
A6-B4-C61 A6-B4-C62 A6-B4-C63 A6-B4-C64 A6-B4-C65 A6-B4-C66
A6-B4-C67 A6-B4-C68 A6-B4-C69 A6-B4-C70 A6-B4-C71 A6-B4-C72
A6-B4-C73 A6-B4-C74 A6-B4-C75 A6-B4-C76 A6-B4-C77 A6-B4-C78
A6-'B4-C79 A6-B4-C80 A6-B4-C81 A6-B4-C82 A6-B4-C83 A6-B4-C84
A6-B4-C85 A6-B4-C86 A6-B4-C87 A6-B4-C88 A6-B4-C89 A6-B4-C90

A6-B4-C91 A6-B4-C92 A6-B4-C93 A6-B4-C94 A6-B4-C95 A6-B4-C96
A6-B4-C97 A6-B4-C98 A6-B4-C99 A6-B4-C100 A6-B4-C101 A6-B4-C102
A6-B4-C103 A6-B4-C104 A6-B4-C105 A6-B4-C106 A6-B4-C107 A6-B4-C108
A6-B4-C109 A6-B4-C110 A6-B4-C111 A6-B4-C112 A6-B4-C113 A6-B4-C114
A6-B4-C115 A6'B4-C116 A6-B4-C117 A6-B4-C118 A6-B4-C119 A6-B4-C120
A6-B4-C121 A6-B4-C122 A6-B4-C123 A6-B4-C124 A6-B4-C125 A6-B4-C126
A6-B4-C127 A6-B4-C128 A6-B4-C129 A6-B4-C130 A6-B4-C131 A6-B4-C132
A6-B4-C133 A6-B4-C134 A6-B4-C135 A6-B4-C136 A6-B4-C137 A6-B4-C138
A6-B4-C139 A6-B4-C140 BLANK BLANK BLANK BLANK
A6-B5-C1 A6-B5-C2 A6-B5-C3 A6-B5-C4 A6-B5-C5 A6-B5-C6
A6-B5-C7 A6-B5-C8 A6-B5-C9 A6-B5-C10 A6-B5-C11 A6-B5-C12
A6-B5-C13 A6-B5-C14 A6-B5-C15 A6-B5-C16 A6-B5-C17 A6-B5-C18
A6-B5-C19 A6-B5-C20 A6-B5-C21 A6-B5-C22 A6-B5-C23 A6-B5-C24
A6-B5-C25 A6-B5-C26 A6-B5-C27 A6-B5-C28 A6-B5-C29 A6-B5-C30
A6-B5-C31 A6-B5-C32 A6-B5-C33 A6-B5-C34 A6-B5-C35 A6-B5-C36
A6-B5-C37 A6-B5-C38 A6-B5-C39 A6-B5-C40 A6-B5-C41 A6-B5-C42
A6-B5-C43 A6-B5-C44 A6-B5-C45 A6-B5-C46 A6-B5-C47 A6-B5-C48
A6-B5-C49 A6-B5-C50 A6-B5-C51 A6-B5-C52 A6-B5-C53 A6-B5-C54
A6-B5-C55 A6-B5-C56 A6-B5-C57 A6-B5-C58 A6-B5-C59 A6-B5-C60
A6-B5-C61 A6-B5-C62 A6-B5-C63 A6-B5-C64 A6-B5-C65 A6-B5-C66
A6-B5-C67 A6-B5-C68 A6-B5-C69 A6-B5-C70 A6-B5-C71 A6-B5-C72
A6-B5-C73 A6-B5-C74 A6-B5-C75 A6-B5-C76 A6-B5-C77 A6-B5-C78
A6-B5-C79 A6-B5-C80 A6-B5-C81 A6-B5-C82 A6-B5-C83 A6-B5-C84
A6-B5-C85 A6-B5-C86 A6-B5-C87 A6-B5-C88 A6-B5-C89 A6-B5-C90
A6-B5-C91 A6-B5-C92 A6-B5-C93 A6'B5-C94 A6-B5-C95 A6-B5-C96
A6-B5-C97 A6-B5-C98 A6-B5-C99 A6-B5-C100 A6-B5-C101 A6-B5-C102
A6-B5-C103 A6-B5-C104 A6-B5-C105 A6-B5-C106 A6-B5-C107 A6-B5-C108
A6-B5-C109 A6-B5-C110 A6-B5-C111 A6-B5-C112 A6-B5-C113 A6-B5-C114
A6-B5-C115 A6-B5-C116 A6-B5-C117 A6-B5-C118 A6-B5-C119 A6-B5-C120
A6-B5-C121 A6-B5-C122 A6-B5-C123 A6-B5-C124 A6-B5-C125 A6-B5-C126
A6-B5-C127 A6-B5-C128 A6-B5-C129 A6-B5-C130 A6-B5-C131 A6-B5-C132
A6-B5-C133 A6-B5-C134 A6-B5-C135 A6-B5-CI36 A6-B5-C137 A6-B5-C138
A6-B5-C139 A6-B5-C140 BLANK BLANK BLANK BLANK
A6-B6-C1 A6-B6-C2 A6-B6-C3 A6-B6-C4 A6-B6-C5 A6-B6-C6
A6-B6-C7 A6-B6-C8 A6-B6-C9 A6-B6-C10 A6-B6-C11 A6-B6-C12
A6-B6-C13 A6-B6-C14 A6-B6-C15 A6-B6-C16 A6-B6-C17 A6-B6-C18
A6-B6-C19 A6-B6-C20 A6-B6-C21 A6-B6-C22 A6-B6-C23 A6-B6-C24

A6-B6-C25 A6-B6-C26 A6-B6-C27 A6-B6-C28 A6-B6-C29 A6-B6-C30
A6-B6-C31 A6-B6-C32 A6-B6-C33 A6-B6-C34 A6-B6-C35 A6-B6-C36
A6-B6-C37 A6-B6-C38 A6-B6-C39 A6-B6-C40 A6-B6-C41 A6-B6-C42
A6-B6-C43 A6-B6-C44 A6-B6-C45 A6-B6-C46 A6-B6-C47 A6-B6-C48
A6-B6-C49 A6-B6-C50 A6-B6-C51 A6-B6-C52 A6-B6-C53 A6-B6-C54
A6-B6-C55 A6-B6-C56 A6-B6-C57 A6-B6-C58 A6-B6-C59 A6-B6-C60
A6-B6-C61 A6-B6-C62 A6-B6-C63 A6-B6-C64 A6-B6-C65 A6-B6-C66
A6-B6-C67 A6-B6-C68 A6-B6-C69 A6-B6-C70 A6-B6-C71 A6-B6-C72
A6-B6-C73 A6-B6-C74 A6-B6-C75 A6-B6-C76 A6-B6-C77 A6-B6-C78
A6-B6-C79 A6-B6-C80 A6-B6-C81 A6-B6-C82 A6-B6-C83 A6-B6-C84
A6-B6-C85 A6-B6-C86 A6-B6-C87 A6-B6-C88 A6-B6-C89 A6-B6-C90
A6-B6-C91 A6-B6-C92 A6-B6-C93 A6-B6-C94 A6-B6-C95 A6-B6-C96
A6-B6-C97 A6-B6-C98 A6-B6-C99 A6-B6-C100 A6-B6-C101 A6-B6-C102
A6-B6-CI03 A6-B6-C104 A6-B6-C105 A6-B6-C106 A6-B6-C107 A6-B6-C108
A6-B6-C109 A6-B6-C110 A6-B6-C111 A6-B6-C112 A6-B6-C113 A6-B6-C114
A6-B6-C115 A6-B6-C116 A6-B6-C117 A6-B6-C118 A6-B6-C119 A6-B6-C120
A6-B6-C121 A6-B6-C122 A6-B6-C123 A6-B6-C124 A6-B6-C125 A6-B6-C126
A6-B6-C127 A6-B6-C128 A6-B6-C129 A6-B6-C130 A6-B6-C131 A6-B6-C132
A6-B6-C133 A6-B6-C134 A6-B6-C135 A6-B6-C136 A6-B6-C137 A6-B6-C138
A6-B6-C139 A6-B6-C140 BLANK BLANK BLANK BLANK
A6-B7-C1 A6-B7-C2 A6-B7-C3 A6-B7-C4 A6-B7-C5 A6-B7-C6
A6-B7-C7 A6-B7-C8 A6-B7-C9 A6-B7-C10 A6-B7-C11 A6-B7-C12
A6-B7-CI3 A6-B7-C14 A6-B7-C15 A6-B7-C16 A6-B7-C17 A6-B7-C18
A6-B7-C19 A6-B7-C20 A6-B7-C21 A6-B7-C22 A6-B7-C23 A6-B7-C24
A6-B7-C25 A6-B7-C26 A6-B7-C27 A6-B7-C28 A6-B7-C29 A6-B7-C30
A6-B7-C31 A6-B7-C32 A6-B7-C33 A6-B7-C34 A6-B7-C35 A6-B7-C36
A6-B7-C37 A6-B7-C38 A6-B7-C39 A6-B7-C40 A6-B7-C41 A6-B7-C42
A6-B7-C43 A6-B7-C44 A6-B7-C45 A6-B7-C46 A6-B7-C47 A6-B7-C48
A6-B7-C49 A6-B7-C50 A6-B7-C51 A6-B7-C52 A6-B7-C53 A6-B7-C54
A6-B7-C55 A6-B7-C56 A6-B7-C57 A6-B7-C58 A6-B7-C59 A6-B7-C60
A6-B7-C61 A6-B7-C62 A6-B7-C63 A6-B7-C64 A6-B7-C65 A6-B7-C66
A6-B7-C67 A6-B7-C68 A6-B7-C69 A6-B7-C70 A6-B7-C71 A6-B7-C72
A6-B7-C73 A6-B7-C74 A6-B7-C75 A6-B7-C76 A6-B7-C77 A6-B7-C78
A6-B7-C79 A6-B7-C80 A6-B7-C81 A6-B7-C82 A6-B7-C83 A6-B7-C84
A6-B7-C85 A6-B7-C86 A6-B7-C87 A6-B7-C88 A6-B7-C89 A6-B7-C90
A6-B7-C91 A6-B7-C92 A6-B7-C93 A6-B7-C94 A6-B7-C95 A6-B7-C96
A6-B7-C97 A6-B7-C98 A6-B7-C99 A6-B7-C100 A6-B7-C101 A6-B7-C102

A6-B7-C103 A6-B7-C104 A6-B7-C105 A6-B7-C106 A6-B7-C107 A6-B7-C108
A6'B7-C109 A6-B7-CI10 A6-B7-C111 A6-B7-C112 A6-B7-C113 A6-B7-C114
A6-B7-C115 A6-B7-C116 A6-B7-C117 A6-B7-C118 A6-B7-C119 A6-B7-C120
A6-B7-C121 A6-B7-C122 A6-B7-C123 A6-B7-C124 A6-B7-C125 A6-B7-C126
A6-B7-C127 A6-B7-C128 A6-B7-C129 A6-B7-C130 A6-B7-C131 A6-B7-C132
A6-B7-C133 A6-B7-C134 A6-B7-C135 A6-B7-C136 A6-B7-C137 A6-B7-CI38
A6-B7-C139 A6-B7-C140 BLANK BLANK BLANK BLANK
A6-B8'C 1 A6-B8-C2 A6-B8-C3 A6-B8-C4 A6-B8-C5 A6-B8-C6
A6-B8-C7 A6-B8-C8 A6-B8-C9 A6-B8-C10 A6-B8-C11 A6-B8-C12
A6-B8-C13 A6-B8-C14 A6-B8-C15 A6-B8-C16 A6-B8-C17 A6-B8-C18
A6-B8-C19 A6-B8-C20 A6-B8-C21 A6-B8-C22 A6-B8-C23 A6-B8-C24
A6-B8-C25 A6-B8-C26 A6-B8-C27 A6-B8-C28 A6-B8-C29 A6-B8-C30
A6-B8-C31 A6-B8-C32 A6-B8-C33 A6-B8-C34 A6-B8-C35 A6-B8-C36
A6-B8-C37 A6-B8-C38 A6-B8-C39 A6-B8-C40 A6-B8-C41 A6-B8-C42
A6-B8-C43 A6-B8'C44 A6'B8-C45 A6-B8-C46 A6-B8-C47 A6-B8-C48
A6-B8-C49 A6-B8-C50 A6-B8-C51 A6-B8-C52 A6-B8-C53 A6-B8-C54
A6-B8-C55 A6-B8-C56 A6-B8-C57 A6-B8-C58 A6-B8-C59 A6-B8-C60
A6-B8-C61 A6-B8-C62 A6-B8-C63 A6-B8-C64 A6-B8-C65 A6-B8-C66
A6-B8-C67 A6-B8-C68 A6-B8-C69 A6-B8-C70 A6-B8-C71 A6-B8-C72
A6-B8-C73 A6-B8-C74 A6-B8-C75 A6-B8-C76 A6-B8-C77 A6-B8-C78
A6-B8-C79 A6-B8-C80 A6-B8-C81 A6-B8-C82 A6-B8-C83 A6-B8-C84
A6-B8-C85 A6-B8-C86 A6-B8-C87 A6-B8-C88 A6-B8-C89 A6'B8-C90
A6-B8-C91 A6-B8-C92 A6-B8-C93 A6-B8-C94 A6-B8-C95 A6-B8-C96
A6-B8-C97 A6-B8-C98 A6-B8-C99 A6-B8-C100 A6-B8-C101 A6-B8-C102
A6-B8-C103 A6-B8-C104 A6-B8-C105 A6-B8-C106 A6-B8-C107 A6-B8-C108
A6-B8-C109 A6-B8-C110 A6-B8-C111 A6-B8-C112 A6-B8-C113 A6-B8-C114
A6'B8-C 115 A6-B8-C116 A6-B8-C117 A6-B8-C118 A6-B8-C119 A6-B8-C120
A6-B8-C121 A6-B8-C122 A6-B8-C123 A6-B8-C124 A6-B8-C125 A6-B8-C126
A6-B8-C127 A6-B8-C128 A6-B8-C129 A6-B8-C130 A6-B8-C131 A6-B8-C132
A6-B8-C133 A6-B8-C134 A6-B8-C135 A6-B8-C136 A6-B8-C137 A6-B8-C138
A6-B8-C139 A6-B8-C140 BLANK BLANK BLANK BLANK
A6-B9-C1 A6-B9-C2 A6-B9-C3 A6-B9-C4 A6-B9-C5 A6-B9-C6
A6-B9-C7 A6-B9-C8 A6-B9-C9 A6-B9-C10 A6-B9-C11 A6-B9-C12
A6-B9-C13 A6-B9-C14 A6-B9-C15 A6-B9-C16 A6-B9-C17 A6-B9-C18
A6-B9-C19 A6-B9-C20 A6-B9-C21 A6-B9-C22 A6-B9-C23 A6-B9-C24
A6-B9-C25 A6-B9-C26 A6-B9-C27 A6-B9-C28 A6-B9-C29 A6-B9-C30
A6-B9-C31 A6-B9-C32 A6-B9-C33 A6-B9-C34 A6-B9-C35 A6-B9-C36

A6-B9-C37 A6-B9-C38 A6-B9-C39 A6-B9-C40 A6-B9-C41 A6-B9-C42
A6-B9-C43 A6-B9-C44 A6-B9-C45 A6-B9-C46 A6-B9-C47 A6-B9-C48
A6-B9-C49 A6-B9-C50 A6-B9-C51 A6-B9-C52 A6-B9-C53 A6-B9-C54
A6-B9-C55 A6-B9-C56 A6-B9-C57 A6-B9-C58 A6-B9-C59 A6-B9-C60
A6-B9-C61 A6-B9-C62 A6-B9-C63 A6-B9-C64 A6-B9-C65 A6-B9-C66
A6-B9-C67 A6-B9-C68 A6-B9-C69 A6-B9-C70 A6-B9-C71 A6-B9-C72
A6-B9.C73 A6-B9-C74 A6-B9-C75 A6-B9-C76 A6-B9-C77 A6-B9-C78
A6--B9-C79 A6-B9-C80 A6-B9-C81 A6-B9-C82 A6-B9-C83 A6-B9-C84
A6-B9-C85 A6-B9-C86 A6-B9-C87 A6-B9-C88 A6-B9-C89 A6-B9-C90
A6-B9-C9I A6-B9-C92 A6-B9-C93 A6-B9-C94 A6-B9-C95 A6-B9-C96
A6-B9-C97 A6-B9-C98 A6-B9-C99 A6-B9-C100 A6-B9-C101 A6-B9-C102
A6-B9-C103 A6.B9-C 104 A6-B9-C105 A6-B9-C106 A6-B9-C107 A6-B9-C108
A6-B9-C109 A6-B9-C110 A6-B9-C111 A6-B9-C112 A6-B9-C113 A6-B9-C114
A6-B9.C 115 A6-B9-C116 A6-B9-C117 A6-B9-C118 A6-B9-C119 A6-B9-C120
A6'B9-C 121 A6-B9-C122 A6-B9-C123 A6-B9-C124 A6-B9-C125 A6-B9-C126
A6-B9-C127 A6-B9-C128 A6-B9-C129 A6-B9-C130 A6-B9-C 131 A6-B9-C132
A6-B9-C133 A6-B9-C134 A6-B9-C135 A6-B9-C136 A6-B9-CI37 A6-B9-Ci38
A6-B9-C139 A6-B9-C140 BLANK BLANK BLANK BLANK
A6-B10-C1 A6-B10-C2 A6-B10-C3 A6-B10-C4 A6-B10-C5 A6-B10-C6
A6-B10-C7 A6-B10-C8 A6-B10-C9 A6-B10-C10 A6-B1 O-C 11 A6-B10-C12
A6-B10-C 13 A6-B10-C 14 A6-B10-C 15 A6-B1 O-C 16 A6'B 10-C 17 A6-B10-C 18
A6-B10-C 19 A6-B10-C20 A6-B10-C21 A6-B 10-C22 A6-B10-C23 A6-B10-C24
A6-B10-C25 A6-B10-C26 A6-B10-C27 A6-B10-C28 A6-B10-C29 A6-B10-C30
A6-B10-C31 A6-B10'C32 A6-B10-C33 A6-B10-C34 A6-B10-C35 A6-B10-C36
A6-B10-C37 A6-B10-C38 A6-B10-C39 A6-B10-C40 A6-B10-C41 A6-B10-C42
A6-B10-C43 A6-B10-C44 A6-B10-C45 A6-B10-C46 A6-B10-C47 A6-B10-C48
A6-B10-C49 A6-B10-C50 A6-B10-C51 A6-B10-C52 A6-B10-C53 A6-B10-C54
A6-B10-C55 A6-B10-C56 A6-B10-C57 A6-B10-C58 A6-B10-C59 A6-B10-C60
A6-B10-C61 A6-B10-C62 A6-B10-C63 A6-B10-C64 A6-B ] 0-C65 A6-B10-C66
A6-B10-C67 A6-B10-C68 A6-B10-C69 A6-B10-C70 A6-B10-C71 A6-B10-C72
A6-B10-C73 A6-B10-C74 A6-B10-C75 A6-B10-C76 A6-B10-C77 A6-B10-C78
A6-B10-C79 A6-B10-C80 A6-B i 0-C81 A6-B10-C82 A6-B10-C83 A6-B10-C84
A6-B10-C85 A6-B10-C86 A6-B10-C87 A6-B10-C88 A6-B10-C89 A6-B10-C90
A6-B10-C91 A6-B10-C92 A6-B10-C93 A6-B10-C94 A6-B10-C95 A6-B10-C96
A6-B10-C97 A6-B10-C98 A6-B10-C99 A6-B10-C 100 A6-B10-C 101 A6-B10-C 102
A6-B10-C 103 A6-B10-C 104 A6-B 10-C 105 A6-B10-C106 A6-B10-C 107 A6-B10-C 108
A6-B10-C 109 A6-B10-C 110 A6-B10-C 111 A6-B10-C 112 A6-B10-C 113 A6-B10-C 114

A6-B10-C115 A6-B10-C116 A6-B10-C117 A6-B10-C118 A6-B10-C119 A6-B10-C120
A6-B10-C 121 A6-B10-C 122 A6-B10-C 123 A6-B10-C 124 A6-B10-C 125 A6-B10-C 126
A6-B10-C 127 A6-B10-C 128 A6-B10-C 129 A6-B10-C 130 A6-B10-C 131 A6-B10-C 132
A6-B10-C133 A6-B10-C134 A6-B10-C135 A6-B10-C136 A6-B10-C137 A6-B10-C138
A6-B10~C139 A6-B10-C140 BLANK BLANK BLANK BLANK
A6-B11 -C1 A6-B11 -C2 A6-B11 -C3 A6-B11 -C4 A6-B11 -C5 A6-B11 -C6
A6-B11 -C7 A6-B11 -C8 A6-B11 -C9 A6-B11 -C10 A6-B 11 -C11 A6-B11 -C12
A6-B11-CI3 A6-B11-C14 A6-B11-C15 A6-B11-C16 A6-B11-C17 A6-B11-C18
A6-B11 -C19 A6-B11-C20 A6-B11 -C21 A6-B11-C22 A6-B 11-C23 A6-B11-C24
A6-B11-C25 A6-B11-C26 A6-B11-C27 A6-B11-C28 A6-B11-C29 A6-B11-C30
A6-B11 -C31 A6-B11-C32 A6-B11-C33 A6-B11-C34 A6-B11 -C3 5 A6-B11-C36
A6-B11-C37 A6-B11 -C3 8 A6-B11-C39 A6-B11-C40 A6-B11 -C41 A6-B11-C42
A6-B11-C43 A6-B11-C44 A6-B11-C45 A6-B11-C46 A6-B11-C47 A6-B11-C48
A6-B11-C49 A6-B11-C50 A6-B11 -C51 A6-B11-C52 A6-B11 'C53 A6-B11-C54
A6-B11-C55 A6-B11-C56 A6-B11-C57 A6-B11-C58 A6-BI1-C59 A6-B11-C60
A6-B1 NC61 A6-B11-C62 A6-B11-C63 A6-B11-C64 A6-B11-C65 A6-B11-C66
A6-B11-C67 A6-B11-C68 A6-B11-C69 A6-B11-C70 A6-B11 -C71 A6-B11-C72
A6-B11 -C73 A6-B11-C74 A6-B11-C75 A6-B11-C76 A6-B11-C77 A6-B11-C78
A6-B11-C79 A6-B11-C80 A6-B1! -C81 A6-B11-C82 A6-B11-C83 A6-B11-C84
A6-B11-C85 A6-B11-C86 A6-B11-C87 A6-B11-C88 A6-B11-C89 A6-B11-C90
A6-B11 -C91 A6'B 11-C92 A6-B11-C93 A6-B11-C94 A6-B11-C95 A6-B11-C96
A6-B11-C97 A6-B11-C98 A6-B11-C99 A6-B11 -C100 A6-B11 -C101 A6-B11 -C102
A6-B11-C103 A6-B11-C104 A6-B11-C105 A6-B11-C106 A6-B11-C107 A6-B11-C108
A6-B11-C109 A6-B11-C110 A6-B11-C111 A6-B11-C112 A6-B11-C113 A6-B11-C114
A6-B11-C115 A6-B11-C116 A6-B11-C117 A6-B11-C118 A6-B11-C119 A6-B11-C120
A6-B11-C121 A6-B11-C122 A6-B11-C123 A6-B11-C124 A6-B11-C125 A6-B11-C126
A6-B11-C127 A6-B11-C128 A6-B11-C129 A6-B11-C130 A6-B11-C131 A6-B11-C132
A6-B11-C133 A6-B11-C134 A6-B11-C135 A6-B11-C136 A6-B11-C137 A6-B11-C138
A6-B! 1-C139 A6-B11-C140 BLANK BLANK BLANK BLANK
A6-B12-C1 A6-B12-C2 A6-B12-C3 A6-B12-C4 A6-B12-C5 A6-B12-C6
A6-B12-C7 A6-B12-C8 A6-B12-C9 A6-B12-C 10 A6-B12-C 11 A6-B12-C 12
A6-BI2-C13 A6-B12-C14 A6-B12-C15 A6-B12-C16 A6-B12-C17 A6-B12-C18
A6-B12-C 19 A6-B12-C20 A6-B12-C21 A6-B12-C22 A6-B12-C23 A6-B12-C24
A6-B12-C25 A6-B12-C26 A6-B12-C27 A6-B12-C28 A6-B12-C29 A6-B12-C30
A6-B12-C31 A6-B12-C32 A6-B12-C33 A6-B12-C34 A6-B12-C35 A6-B12-C36
A6-B12-C37 A6-B12-C38 A6-B12-C39 A6-B12-C40 A6-B12-C41 A6-B12-C42
A6-B12-C43 A6-B12-C44 A6-B12-C45 A6-B12-C46 A6-B12-C47 A6-B12-C48

A6-B12-C49 A6-B12-C50 A6-B12-C51 A6-B12-C52 A6-B12-C53 A6-B ] 2-C54
A6-B12-C55 A6-B12-C56 A6-B12-C57 A6-B12-C58 A6-B12-C59 A6-B12-C60
A6-B12-C61 A6-B12-C62 A6-B12-C63 A6'B 12-C64 A6-B12-C65 A6-B12-C66
A6-B12-C67 A6-B12-C68 A6-B12-C69 A6-B12-C70 A6-B12-C71 A6-B12-C72
A6-B12-C73 A6-B12-C74 A6-B12-C75 A6-B12-C76 A6-B12-C77 A6-B12-C78
A6-B12-C79 A6-B12-C80 A6-B12-C81 A6-B12-C82 A6-B12-C83 A6-B12-C84
A6-B12-C85 A6-B12-C86 A6-B12-C87 A6-B12-C88 A6-B12-C89 A6-B12-C90
A6-B12-C91 A6-B12-C92 A6-B12-C93 A6-B12-C94 A6-B12-C95 A6-B12-C96
A6-B12-C97 A6-B12-C98 A6-B12-C99 A6-B12-C100 A6-B12-C101 A6'B 12-C102
A6-B12-C 103 A6-B12-C 104 A6-B12-C 105 A6-B12-C 106 A6-B12-C 107 A6-B12-C 108
A6-B12-C 109 A6-B12-C 110 A6-B12-C 111 A6-B12-C 112 A6-B12-C 113 A6-B12'C 114
A6-B12-C 115 A6-B12-C 116 A6-B12-C 117 A6-B12-C 118 A6-B12-C 119 A6-B12-C 120
A6-B12-C 121 A6-B12-C 122 A6-B12-C 123 A6-B12-C i 24 A6-B12-C 125 A6-B12-C 126
A6-B12-C 127 A6-B12-C 128 A6-B12-C 129 A6-B12-C 130 A6-B12-C 131 A6-B12-C 132
A6-B12-CI33 A6-B12-C134 A6-B12-C135 A6-B12-C136 A6'B12-C137 A6-B12-C138
A6-B12-C139 A6-B12-C140 BLANK BLANK BLANK BLANK
A6-B13-C1 A6-B13-C2 A6-B13-C3 A6-B13-C4 A6-B13-C5 A6-B13-C6
A6-B13-C7 A6-B13-C8 A6-B13-C9 A6-B13-C10 A6-BI3-C11 A6-B13-C12
A6-B13-C13 A6-B13-C14 A6-B13-C15 A6-B13-C16 A6-B13-C17 A6-B13-C18
A6-B13-C19 A6-B13-C20 A6-B13-C21 A6-B13-C22 A6-B13-C23 A6-B13-C24
A6-B13-C25 A6-B13-C26 A6-B13-C27 A6-B13-C28 A6-B13-C29 A6-B13-C30
A6-B13-C31 A6-B13-C32 A6-B13-C33 A6-B13-C34 A6-B13-C3 5 A6-B13-C36
A6-B13-C37 A6-B13-C38 A6-B13-C39 A6-B13-C40 A6-B13-C41 A6-B13-C42
A6-B13-C43 A6-B13-C44 A6-B13-C45 A6-B13-C46 A6-B13-C47 A6-B13-C48
A6-B13-C49 A6-B13-C50 A6-B13-C51 A6-B13-C52 A6-B13-C53 A6-B13-C54
A6-B13-C55 A6-B13-C56 A6-B13-C57 A6-B13-C58 A6-B13-C59 A6-B13-C60
A6-B13-C61 A6-B13-C62 A6-B13-C63 A6-B 13-C64 A6-B13-C65 A6-B13-C66
A6-B13-C67 A6-B13-C68 A6-B13-C69 A6-B13-C70 A6-B13-C71 A6-B13-C72
A6-B13-C73 A6-B13-C74 A6-B13-C75 A6-B13-C76 A6-B13-C77 A6-B13-C78
A6-B13-C79 A6-B13-C80 A6-B13-C81 A6-B13-C82 A6-B13-C83 A6-B13-C84
A6-B13-C85 A6-B13-C86 A6'B 13-C87 A6-B13-C88 A6-B13-C89 A6-B13-C90
A6-B13-C91 A6-B13-C92 A6-B13-C93 A6-B13-C94 A6-B13-C95 A6-B13-C96
A6-B13-C97 A6-B13-C98 A6-B13-C99 A6-B13-C100 A6-B13-C101 A6-B13-C102
A6-B13-C103 A6-B13-C104 A6-B13-C105 A6-B13-C106 A6-B13-C107 A6-B13-C108
A6-B13-C109 A6-B13-C110 A6-B13-C111 A6-B13-C112 A6-B13-C113 A6-B13-C114
A6-B13-C 115 A6-B13-C 116 A6-B13-C i 17 A6-B13-C 118 A6-B13-C 119 A6-B13-C 120
A6-B13-C121 A6-B13-C122 A6-B13-C123 A6-B13-C124 A6-B13-C125 A6-B13-C126

A6-B13-C.127 A6-B13-C128 A6-B13-C129 A6-B13-C130 A6-B13-C131 A6-B13-C132
A6-B13-C133 A6-B13-C134 A6-B13-C135 A6-BI3-C136 A6-B13-C137 A6-B13-C138
A6-B13-C139 A6-B13-C140 BLANK BLANK BLANK BLANK
A7-B1-C1 A7-B1-C2 A7-B1-C3 A7-B1-C4 A7-B1-C5 A7-B1-C6
A7-B1-C7 A7-B1-C8 A7-B1-C9 A7-B1-C10 A7-Bl-Cn A7-B1-C12
A7-B1-C13 A7-B1-C14 A7-B1-C15 A7-B1-C16 A7-Bl-Cn A7-B1-C18
A7-B1-C19 A7-B1-C20 A7-B1-C21 A7-B1-C22 A7-B1-C23 A7-B1-C24
A7-B1-C25 A7-BI-C26 A7-B1-C27 A7-B1-C28 A7-B1-C29 A7-B1-C30
A7-B1-C3I A7-B1-C32 A7-B1-C33 A7-B1-C34 A7-B1-C35 A7-B1-C36
A7-B1-C37 A7-B1-C38 A7-B1-C39 A7-B1-C40 A7-B1-C41 A7-B1-C42
A7-B1-C43 A7-BI-C44 A7-B1-C45 A7-B1-C46 A7-B1-C47 A7-B1-C48
A7-B1-C49 A7-B1-C50 A7-B1-C51 A7-B1-C52 A7-B1-C53 A7-B1-C54
A7-B1-C55 A7-B1-C56 A7-B1-C57 A7-B1-C58 A7-B1-C59 A7-B1-C60
A7-B1-C61 A7-B1-C62 A7-B1-C63 A7-B1-C64 A7-B1-C65 A7-B1-C66
A7-B1-C67 A7-B1-C68 A7-B1-C69 A7-B1-C70 A7-B1-C71 A7-B1-C72
A7-B1-C73 A7-B1-C74 A7-B1-C75 A7-B1-C76 A7-BI-C77 A7-B1-C78
A7-B1-C79 A7-B1-C80 A7-B1-C81 A7-B1-C82 A7-B1-C83 A7-B1-C84
A7-B1-C85 A7-B1-C86 A7-B1-C87 A7-B1-C88 A7-B1-C89 A7-B1-C90
A7-B1-C91 A7-B1-C92 A7-B1-C93 A7-BI-C94 A7-B1-C95 A7-B1-C96
A7-B1-C97 A7-B1-C98 A7-B1-C99 A7-B1-C100 A7-B1-C101 A7-B1-C102
A7-B1-C103 A7-B1-C104 A7-B1-CI05 A7-B1-C106 A7-B1-C107 A7-B1-C108
A7-B1-C109 A7-Bl-Cn0 A7-B1-C1I1 A7-BNCn2 A7-B1-C113 A7-B1-C114
A7-B1-C115 A7-BI-C116 A7-B1-C117 A7-B1-C118 A7-B1-C119 A7-B1-C120
A7-B1-C121 A7-B1-CI22 A7-B1-C123 A7-B1-C124 A7-B1-C125 A7-B1-C126
A7-B1-C127 A7-B1-C128 A7-B1-C129 A7-B1-C130 A7-B1-C131 A7-B1-C132
A7-B1-C133 A7-B1-C134 A7-B1-C135 A7-B1-C136 A7-B1-C137 A7-B1-C138
A7-B1-C139 A7-B1-C140 BLANK BLANK BLANK BLANK
A7-B2-C1 A7-B2-C2 A7-B2-C3 A7-B2-C4 A7-B2-C5 A7-B2-C6
A7-B2-C7 A7-B2-C8 A7-B2-C9 A7-B2-C10 A7-B2-Cn A7-B2-C12
A7-B2-C13 A7-B2-C14 A7-B2-C15 A7-B2-C16 A7-B2-C17 A7-B2-C18
A7-B2-C19 A7-B2-C20 A7-B2-C21 A7-B2-C22 A7-B2-C23 A7-B2-C24
A7-B2-C25 A7-B2-C26 A7-B2-C27 A7-B2-C28 A7-B2-C29 A7-B2-C30
A7-B2-C3) A7-B2-C32 A7-B2-C33 A7-B2-C34 A7-B2-C35 A7-B2-C36
A7-B2-C37 A7-B2-C38 A7-B2-C39 A7-B2-C40 A7-B2-C41 A7-B2-C42
A7-B2-C43 A7-B2-C44 A7-B2-C45 A7-B2-C46 A7-B2-C47 A7-B2-C48
A7-B2-C49 A7-B2-C50 A7-B2-C51 A7-B2-C52 A7-B2-C53 A7-B2-C54
A7-B2-C55 A7-B2-C56 A7-B2-C57 A7-B2-C58 A7-B2-C59 A7-B2-C60

A7-B2-C61 A7-B2-C62 A7-B2-C63 A7-B2-C64 A7-B2-C65 A7-B2-C66
A7-B2-C67 A7-B2-C68 A7-B2-C69 A7-B2-C70 A7-B2-C71 A7-B2-C72
A7-B2-C73 A7-B2-C74 A7-B2-C75 A7-B2-C76 A7-B2-C77 A7-B2-C78
A7-B2-C79 A7-B2-C80 A7-B2-C81 A7-B2-C82 A7-B2-C83 A7-B2-C84
A7-B2-C85 A7-B2-C86 A7-B2-C87 A7-B2-C88 A7-B2-C89 A7-B2-C90
A7-B2-C91 A7-B2-C92 A7-B2-C93 A7-B2-C94 A7-B2-C95 A7-B2-C96
A7-B2-C97 A7-B2-C98 A7-B2-C99 A7-B2-C100 A7-B2-C101 A7-B2-C102
A7-B2-C103 A7-B2-C104 A7-B2-C105 A7-B2-C106 A7-B2-C107 A7-B2-C108
A7-B2-C109 A7-B2-C110 A7-B2-CI11 A7-B2-CI12 A7-B2-C] 13 A7-B2-C114
A7-B2-C115 A7-B2-C116 A7-B2-C117 A7-B2-C118 A7-B2-C119 A7-B2-C120
A7-B2-C121 A7-B2-C122 A7-B2-C123 A7-B2-C124 A7-B2-C125 A7-B2-C126
A7-B2-C127 A7-B2-C128 A7-B2-C129 A7-B2-C130 A7-B2-C131 A7-B2-C132
A7-B2-C133 A7-B2-C134 A7-B2-C135 A7-B2-C136 A7-B2-C137 A7-B2-C138
A7-B2-C139 A7-B2-C140 BLANK BLANK BLANK BLANK
A7-B3-CI A7-B3-C2 A7-B3-C3 A7-B3-C4 A7-B3-C5 A7-B3-C6
A7-B3-C7 A7-B3-C8 A7-B3-C9 A7-B3-C10 A7-B3-C11 A7-B3-C12
A7-B3-C13 A7-B3-C14 A7-B3-C15 A7-B3-C16 A7-B3-C17 A7-B3-C18
A7-B3-CI9 A7-B3-C20 A7-B3-C21 A7-B3-C22 A7-B3-C23 A7-B3-C24
A7-B3-C25 A7-B3-C26 A7-B3-C27 A7-B3-C28 A7-B3-C29 A7-B3-C30
A7-B3-C31 A7-B3-C32 A7-B3-C33 A7-B3-C34 A7-B3-C35 A7-B3-C36
A7-B3-C37 A7-B3-C38 A7-B3-C39 A7-B3-C40 A7-B3-C41 A7-B3-C42
A7-B3-C43 A7-B3-C44 A7-B3-C45 A7-B3-C46 A7-B3-C47 A7-B3-C48
A7-B3-C49 A7-B3-C50 A7-B3-C5] A7-B3-C52 A7-B3-C53 A7-B3-C54
A7-B3-C55 A7-B3-C56 A7-B3-C57 A7-B3-C58 A7-B3-C59 A7-B3-C60
A7-B3-C61 A7-B3-C62 A7-B3-C63 A7-B3-C64 A7-B3-C65 A7-B3-C66
A7-B3-C67 A7-B3-C68 A7-B3-C69 A7-B3-C70 A7-B3-C71 A7-B3-C72
A7-B3-C73 A7-B3-C74 A7-B3-C75 A7-B3-C76 A7-B3-C77 A7-B3-C78
A7-B3-C79 A7-B3-C80 A7-B3-C81 A7-B3-C82 A7-B3-C83 A7-B3-C84
A7-B3-C85 A7-B3-C86 A7-B3-C87 A7-B3-C88 A7-B3-C89 A7-B3-C90
A7-B3-C91 A7'B3-C92 A7-B3-C93 A7-B3-C94 A7-B3-C95 A7-B3-C96
A7-B3-C97 A7-B3-C98 A7-B3-C99 A7-B3-C100 A7-B3-C101 A7-B3-CI02
A7-B3-C103 A7-B3-C104 A7-B3-C105 A7-B3-C]06 A7-B3-C107 A7-B3-C108
A7-B3-C109 A7-B3-C110 A7-B3-C111 A7-B3-C112 A7-B3-C113 A7-B3-C114
A7-B3-C115 A7-B3-C116 A7-B3-C117 A7-B3-C118 A7-B3-C119 A7-B3-CI20
A7-B3-C121 A7-B3-CI22 A7-B3-C123 A7-B3-C124 A7-B3-C125 A7-B3-C126
A7-B3-C127 A7-B3-C128 A7-B3-C129 A7-B3-C130 A7-B3-C131 A7-B3-C132
A7-B3-C133 A7-B3-C134 A7-B3-C135 A7-B3-C136 A7-B3-CI37 A7-B3.C138

A7-B3-C139 A7-B3-C140 BLANK BLANK BLANK BLANK
A7-B4-CI A7-B4-C2 A7-B4-C3 A7-B4-C4 A7-B4-C5 A7-B4-C6
A7-B4-C7 A7-B4-C8 A7-B4-C9 A7-B4-C10 A7-B4-C11 A7-B4-C12
A7-B4-C13 A7-B4-C14 A7-B4-C15 A7-B4-C16 A7-B4-C17 A7-B4-C18
A7-B4-C19 A7-B4-C20 A7-B4-C21 A7-B4-C22 A7-B4-C23 A7-B4-C24
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A7-B4-C43 A7-B4-C44 A7-B4-C45 A7-B4-C46 A7-B4-C47 A7-B4-C48
A7-B4-C49 A7-B4'C50 A7-B4-C51 A7-B4-C52 A7-B4-C53 A7-B4-C54
A7-B4-C55 A7-B4-C56 A7-B4-C57 A7-B4-C58 A7-B4-C59 A7-B4-C60
A7-B4-C61 A7-B4-C62 A7-B4-C63 A7-B4-C64 A7-B4-C65 A7-B4-C66
A7-B4-C67 A7-B4-C68 A7-B4-C69 A7-B4-C70 A7-B4-C71 A7-B4-C72
A7-B4-C73 A7-B4-C74 A7-B4-C75 A7-B4-C76 A7-B4-C77 A7-B4-C78
A7-B4-C79 A7-B4-C80 A7-B4-C81 A7-B4-C82 A7-B4-C83 A7-B4-C84
A7-B4-C85 A7-B4-C86 A7-B4-C87 A7-B4-C88 A7-B4-C89 A7-B4-C90
A7-B4-C91 A7-B4-C92 A7-B4-C93 A7-B4-C94 A7-B4-C95 A7-B4-C96
A7-B4-C97 A7-B4-C98 A7-B4-C99 A7-B4-C100 A7-B4-C101 A7-B4-C102
A7-B4-C103 A7-B4-C104 A7-B4-C105 A7-B4-C106 A7-B4-C107 A7-B4-C108
A7-B4-C109 A7-B4-C110 A7-B4-C111 A7-B4-C112 A7-B4-C113 A7-B4-C114
A7-B4-C115 A7-B4-C116 A7-B4-C117 A7-B4-C118 A7-B4-C119 A7-B4-C120
A7-B4-C121 A7-B4-C122 A7-B4-C123 A7-B4-C124 A7-B4-C125 A7-B4-C126
A7-B4-C 127 A7-B4-C128 A7-B4-C129 A7-B4-C130 A7-B4-C131 A7-B4-C132
A7-B4-C133 A7-B4-C134 A7-B4-C135 A7-B4-C136 A7-B4-C137 A7-B4-C13 8
A7-B4-C139 A7-B4-C140 BLANK BLANK BLANK BLANK
A7-B5-CI A7-B5-C2 A7-B5-C3 A7-B5-C4 A7-B5-C5 A7-B5-C6
A7-B5-C7 A7-B5-C8 A7-B5-C9 A7-B5-C10 A7-B5-C11 A7-B5-C12
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A7-B5-C37 A7-B5-C38 A7-B5-C39 A7-B5-C40 A7-B5-C41 A7-B5-C42
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A7-B5-C49 A7-B5-C50 A7-B5-C51 A7-B5-C52 A7-B5-C53 A7-B5-C54
A7-B5-C55 A7-B5-C56 A7-B5-C57 A7-B5-C58 A7-B5-C59 A7-B5-C60
A7-B5-C61 A7-B5-C62 A7-B5-C63 A7-B5-C64 A7-B5-C65 A7-B5-C66
A7-B5-C67 A7-B5-C68 A7-B5-C69 A7-B5-C70 A7-B5-C71 A7-B5-C72

A7-B5-C73 A7-B5-C74 A7-B5-C75 A7-B5-C76 A7-B5-C77 A7-B5-C78
A7-B5-C79 A7-B5-C80 A7-B5-C81 A7-B5-C82 A7-B5-C83 A7-B5-C84
A7-B5-C85 A7-B5-C86 A7-B5-C87 A7-B5-C88 A7-B5-C89 A7-B5-C90
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A7-B5-C97 A7-B5-C98 A7-B5-C99 A7-B5-C100 A7-B5-C101 A7-B5-CI02
A7-B5-C103 A7-B5-C104 A7-B5-C105 A7-B5-C106 A7-B5-C107 A7-B5-C108
A7-B5-C109 A7-B5-C110 A7-B5-C111 A7-B5-Cn2 A7-B5-C113 A7-B5-C114
A7-B5-C115 A7-B5-C116 A7-B5-C117 A7-B5-C118 A7-B5-C119 A7-B5-C120
A7-B5-C121 A7-B5-C122 A7-B5-C123 A7-B5-C124 A7-B5-C125 A7-B5-C126
A7-B5-C127 A7-B5-C128 A7-B5-C129 A7-B5-C130 A7-B5-C131 A7-B5-C132
A7-B5-C133 A7-B5-C134 A7-B5-C135 A7-B5-C136 A7-B5-C137 A7-B5-C138
A7-B5-C139 A7-B5-C140 BLANK BLANK BLANK BLANK
A7-B6-C1 A7-B6-C2 A7-B6-C3 A7-B6-C4 A7-B6-C5 A7-B6-C6
A7-B6-C7 A7-B6-C8 A7-B6-C9 A7-B6-C10 A7-B6-C11 A7-B6-C12
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A7-B6-C55 A7-B6-C56 A7-B6-C57 A7-B6-C58 A7-B6-C59 A7-B6-C60
A7-B6-C61 A7-B6-C62 A7-B6-C63 A7-B6-C64 A7-B6-C65 A7-B6-C66
A7-B6-C67 A7-B6-C68 A7-B6-C69 A7-B6-C70 A7-B6-C71 A7-B6-C72
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A7-B6-C91 A7-B6-C92 A7-B6-C93 A7-B6-C94 A7-B6-C95 A7-B6-C96
A7-B6-C97 A7-B6-C98 A7-B6-C99 A7-B6-C100 A7-B6-C101 A7-B6-C102
A7-B6-C103 A7-B6-C104 A7-B6-C105 A7-B6-C106 A7-B6-C107 A7-B6-C108
A7-B6-C109 A7-B6-C110 A7-B6-C111 A7-B6-C112 A7-B6-Cn3 A7-B6-C114
A7-B6-C115 A7-B6-C116 A7-B6-C117 A7-B6-Cn8 A7-B6-C119 A7-B6-C120
A7-B6-C121 A7-B6-C122 A7-B6-C123 A7-B6-C124 A7-B6-C125 A7-B6-C126
A7-B6-C127 A7-B6-C128 A7-B6-C129 A7-B6-C130 A7-B6-C131 A7-B6-C132
A7-B6-C133 A7-B6-C134 A7-B6-C135 A7-B6-C136 A7-B6-C137 A7-B6-C138
A7-B6-C139 A7-B6-C140 BLANK BLANK BLANK BLANK
A7-B7-C1 A7-B7-C2 A7-B7-C3 A7-B7-C4 A7-B7-C5 A7-B7-C6

A7-B7-C7 A7-B7-C8 A7-B7-C9 A7-B7-C10 A7-B7-C11 A7-B7-C12
A7-B7-C13 A7'B7-C 14 A7-B7-C15 A7-B7-C16 A7-B7-C17 A7-B7-C18
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A7-B7-C43 A7-B7-C44 A7-B7-C45 A7-B7-C46 A7-B7-C47 A7-B7-C48
A7-B7-C49 A7-B7-C50 A7-B7-C51 A7-B7-C52 A7-B7-C53 A7-B7'C54
A7-B7-C55 A7-B7-C56 A7-B7-C57 A7-B7-C58 A7-B7-C59 A7-B7-C60
A7-B7-C61 A7-B7-C62 A7-B7-C63 A7-B7-C64 A7-B7-C65 A7-B7-C66
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A7-B7-C109 A7-B7-C110 A7-B7-C111 A7-B7-C112 A7-B7-C113 A7-B7-C114
A7-B7-C115 A7-B7-C116 A7-B7-C117 A7-B7-C118 A7-B7-C119 A7-B7-C120
A7-B7-C121 A7-B7-C122 A7-B7-C123 A7-B7-C124 A7-B7-C125 A7-B7-C126
A7-B7-C127 A7-B7-C128 A7-B7-C129 A7-B7-C130 A7-B7-C131 A7-B7-C132
A7-B7-C133 A7-B7'C134 A7-B7-C135 A7-B7-CI36 A7-B7-C137 A7-B7-C138
A7-B7-C139 A7-B7-C140 BLANK BLANK BLANK BLANK
A7-B8-C1 A7-B8-C2 A7-B8-C3 A7-B8-C4 A7-B8-C5 A7-B8-C6
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A7-B8-C49 A7-B8-C50 A7-B8-C51 A7-B8-C52 A7-B8-C53 A7-B8-C54
A7-B8-C55 A7-B8-C56 A7-B8-C57 A7-B8-C58 A7-B8-C59 A7-B8-C60
A7~B8-C61 A7'B8'C62 A7-B8-C63 A7-B8-C64 A7-B8-C65 A7-B8-C66
A7-B8-C67 A7-B8-C68 A7-B8'C69 A7-B8-C70 A7-B8-C71 A7-B8-C72
A7-B8-C73 A7-B8-C74 A7-B8-C75 A7-B8-C76 A7-B8-C77 A7-B8-C78
A7-B8-C79 A7-B8-C80 A7-B8-C81 A7-B8-C82 A7-B8-C83 A7-B8-C84

A7-B8-C85 A7-B8-C86 A7-B8-C87 A7-B8-C88 A7-B8-C89 A7-B8-C90
A7-B8-C91 A7-B8-C92 A7-B8-C93 A7-B8-C94 A7-B8-C95 A7-B8-C96
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A7-B8-C103 A7-B8-C104 A7-B8-C105 A7-B8-C106 A7-B8-C107 A7-B8-C108
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A7-B8-C127 A7-B8-C128 A7-B8-C129 A7-B8-C130 A7-B8-C131 A7-B8-C132
A7-B8-C133 A7-B8-C134 A7-B8-C135 A7-B8-C136 A7-B8-C137 A7-B8-C138
A7-B8-C139 A7-B8-C140 BLANK BLANK BLANK BLANK
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A7-B9-C121 A7-B9-C122 A7-B9-C123 A7-B9-C124 A7-B9-C125 A7-B9-C126
A7-B9-C127 A7-B9-C128 A7-B9-C129 A7-B9-C130 A7-B9-C131 A7-B9-C132
A7-B9-C133 A7-B9-C134 A7-B9-C135 A7-B9-C136 A7-B9-C13 7 A7-B9-C13 8
A7-B9-C139 A7-B9-C140 BLANK BLANK BLANK BLANK
A7-B10-C1 A7-B10-C2 A7-B10-C3 A7-B10-C4 A7-B10-C5 A7-B10-C6
A7-B10-C7 A7-B10-C8 A7-B10-C9 A7-B10-C 10 A7-B10-C 11 A7-B10-C 12
A7-B10-C 13 A7-B10-C 14 A7-B10-C 15 A7-B10-C 16 A7-B10-C 17 A7-B10-C 18

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A7-B10-C85 A7-B10-C86 A7-B10-C87 A7-B10-C88 A7-B10-C89 A7-B10-C90
A7-B10-C91 A7-B10-C92 A7-BI0-C93 A7-B10-C94 A7-B10-C95 A7-BI0-C96
A7-B10-C97 A7-B10-C98 A7-B10-C99 A7-B10-C100 A7-B10-C101 A7-B10-C102
A7-B10-C103 A7-B10-C104 A7-B10-C105 A7-B10-C106 A7-B10-CI07 A7-B10-C108
A7-B10-C109 A7-B10-C110 A7-B10-C111 A7-B10-C112 A7-B10-Cn3 A7-B10-C114
A7-B10-C115 A7-B10-C116 A7-B10-C117 A7-B10-C118 A7-B10-Cn9 A7-B10-C120
A7-B10-C121 A7-B10-C122 A7-B10-C123 A7-B10-C124 A7-B10-C125 A7-B10-C126
A7-B10-C127 A7-B10-C128 A7-B10-C129 A7-B10-C130 A7-B10-C131 A7-B10-C132
A7-BIO-CI33 A7-B10-C134 A7-B10-C135 A7-B10-C136 A7-B10-C137 A7-B10-C138
A7-B10-C139 A7-B10-C140 BLANK BLANK BLANK BLANK
A7-Bn-Cl A7-Bn-C2 A7-B11-C3 A7-B11-C4 A7-B11-C5 A7-B11-C6
A7-B11-C7 A7-B11-C8 A7-B11-C9 A7-B11-C10 A7-B1I.C11 A7-B1I-C12
A7-B11-C13 A7-B11-C14 A7-B11-C15 A7-Bn-C16 A7-Bn-C17 A7-B11-C18
A7-Bn-C19 A7-B11-C20 A7-B11-021 A7-B11-C22 A7-B11-C23 A7-B11-C24
A7-B11-C25 A7-B11-C26 A7-B11-C27 A7-B11-C28 A7-B11-C29 A7-B11-C30
A7-B11-C31 A7-B11-C32 A7-B11-C33 A7-B11-C34 A7-B11-C35 A7-B1I-C36
A7-B11-C37 A7-Bn-C38 A7-B11-C39 A7-B11-C40 A7-B11-C41 A7-B11-C42
A7-B11-C43 A7-B11-C44 A7-B11-C45 A7-B11-C46 A7-B1J-C47 A7-BI1-C48
A7-B11-C49 A7-B11-C50 A7-B11-C51 A7-B1I-C52 A7-B11-C53 A7-B11-C54
A7-B11-C55 A7-B11-C56 A7-B11-C57 A7-B11-C58 A7-B11-C59 A7-B11-C60
A7-B11-C61 A7-B11-C62 A7-B1LC63 A7-B1I-C64 A7-B1I-C65 A7-B11-C66
A7-B11-C67 A7-B11-C68 A7-B11-C69 A7-B11-C70 A7-B1I-C71 A7-B11-C72
A7-B11-C73 A7-BU-C74 A7-B11-C75 A7-B11-C76 A7-B11-C77 A7-B11-C78
A7-B11-C79 A7-B11-C80 A7-B11-C81 A7-B11-C82 A7-B11-C83 A7-B11-C84
A7-B11-C85 A7-BII-C86 A7-B11-087 A7-B11-C88 A7-B11-C89 A7-B11-C90
A7-B11-C91 A7-B11-C92 A7-B11-C93 A7-BI1-C94 A7-B11-C95 A7-B11-C96

A7-BU-C97 A7-Bn-C98 A7-B11-C99 A7-B11-CIO0 A7-B1I-CI01 A7-B1I-CI02
A7-B11-C103 A7-B11-C104 A7-B11-C105 A7-B11-C106 A7-B11-CI07 A7-B11-C108
A7-B11-C109 A7-Bll-Cn0 A7-BI1-C111 A7-Bn-C112 A7-B11-CU3 A7-Bn-C114
A7-B11-C115 A7-B11-C116 A7-B11-C117 A7-Bn-C118 A7-Bn-Cn9 A7-B11-C120
A7-Bn-C121 A7-B1NC122 A7-B11-C123 A7-B11-C124 A7-Bn-C125 A7-B11-CI26
A7-BI1-C127 A7-Bn-C128 A7-B11-C129 A7-Bn-C130 A7-B11-C131 A7-B11-C132
A7-B11-C133 A7-B11-C134 A7-B11-C135 A7-B1UC136 A7-B11-C137 A7-B11-C138
A7-Bn-C139 A7-B11-C140 BLANK BLANK BLANK BLANK
A7-B12-C1 A7-B12~C2 A7-B12-C3 A7-B12-C4 A7-B12-C5 A7-B12-C6
A7-B12-C7 A7-B12-C8 A7-B12-C9 A7-B12-CI0 A7-B12-C11 A7-B12-C12
A7-B12-C13 A7-B12-C14 A7-B12-C15 A7-B12-C16 A7-B12-C17 A7-B12-C18
A7-B12-C19 A7-B12-C20 A7-B12-C21 A7-B12-C22 A7-B12-C23 A7-B12-C24
A7-B12-C25 A7-B12-C26 A7-B12-C27 A7-B12-C28 A7-B12-C29 A7-B12-C30
A7-B12-C31 A7-B12-C32 A7-B12-C33 A7-B12-C34 A7-B12-C35 A7-B12-C36
A7-B12-C37 A7-B12-C38 A7-B12-C39 A7-B12-C40 A7-B12-C41 A7-B12-C42
A7-B12-C43 A7-B12-C44 A7-B12-C45 A7-B12-C46 A7-B12-C47 A7-B12-C48
A7-B12-C49 A7-B12-C50 A7-B12-C51 A7-B12-C52 A7-B12-C53 A7-B12-C54
A7-B12-C55 A7-B12-C56 A7-B12-C57 A7-B12-C58 A7-B12-C59 A7-BI2-C60
A7-B12-C61 A7-B12-C62 A7-B12-C63 A7-B12-C64 A7-B12-C65 A7-B12-C66
A7-B12-C67 A7-B12-C68 A7-B12-C69 A7-B12-C70 A7-B12-C71 A7-B12-C72
A7-B12-C73 A7-B12-C74 A7-B12-C75 A7-B12-C76 A7-B12-C77 A7-B12-C78
A7-B12-C79 A7-B12-C80 A7-B12-C81 A7-B12-C82 A7-B12-C83 A7-B12-C84
A7-B12-C85 A7-B12-C86 A7-B12-C87 A7-B12-C88 A7-B12-C89 A7-B12-C90
A7-B12-C91 A7-B12-C92 A7-B12-C93 A7-B12-C94 A7-B12-C95 A7-B12-C96
A7-B12-C97 A7-B12-C98 A7-B12-C99 A7-B12-C100 A7-B12-C101 A7-B12-C102
A7-B12-C103 A7-B12-C104 A7-B12-C105 A7-B12-C106 A7-B12-C107 A7-BI2-C108
A7-B12-C109 A7-B12-Cn0 A7-B12-C111 A7-B12-C112 A7-B12-C113 A7-B12-C114
A7-B12-Cn5 A7-B12-Cn6 A7-B12-C117 A7-B12-Cn8 A7-B12-Cn9 A7-B12-C120
A7-B12-C121 A7-B12-C122 A7-B12-C123 A7-B12-C124 A7-B12-C125 A7-B12-C126
A7-B12-C127 A7-B12-C128 A7-B12-C129 A7-B12-C130 A7-B12-C131 A7-B12-C132
A7-B12-C133 A7-B12-C134 A7-B12-C135 A7-B12-C136 A7-B12-C137 A7-B12-C138
A7-BI2-C139 A7-B12-C140 BLANK BLANK BLANK BLANK
A7-B13-C1 A7-B13-C2 A7-B13-C3 A7-B13-C4 A7-B13-C5 A7-B13-C6
A7-B13-C7 A7-B13-C8 A7-B13-C9 A7-B13-C10 A7-B13-Cn A7-B13-C12
A7-B13-C13 A7-B13-C14 A7-B13-C15 A7-B13-C16 A7-B13-C17 A7-B13-C18
A7-B13-C19 A7-B13-C20 A7-B13-C21 A7-B13-C22 A7-B13-C23 A7-B13-C24
A7-B13-C25 A7-B13-C26 A7-B13-C27 A7-B13-C28 A7-B13-C29 A7-B13-C30

A7-B13-C31 A7-B13-C32 A7-B13-C33 A7-B13-C34 A7-B13-C35 A7-BI3-C36
A7-B13-C37 A7-B13-C38 A7-B13-C39 A7-B13-C40 A7-B13-C41 A7-B13-C42
A7-B13-C43 A7-B13-C44 A7-B13-C45 A7-B13-C46 A7-B13-C47 A7-B13-C48
A7-B13-C49 A7-B13-C50 A7-B13-C51 A7-B13-C52 A7-B13-C53 A7-B13-C54
A7-B13-C55 A7-B13-C56 A7-B13-C57 A7-BI3-C58 A7-B13-C59 A7-B13-C60
A7-B13-C6I A7-B13-C62 A7-B13-C63 A7-B13-C64 A7-B13-C65 A7-B13-C66
A7-B13-C67 A7-B13-C68 A7-B13-C69 A7-B13-C70 A7-B13-C71 A7-B13-C72
A7-B13-C73 A7-B13-C74 A7-B13-C75 A7-B13-C76 A7-B13-C77 A7-B13-C78
A7-B13-C79 A7-B13-C80 A7-B13-C81 A7-B13-C82 A7-B13-C83 A7-B13-C84
A7-BI3-C85 A7-B13-C86 A7-B13-C87 A7-BI3-C88 A7-B13-C89 A7-B13-C90
A7-B13-C91 A7-B13-C92 A7-B13-C93 A7-B13-C94 A7-B13-C95 A7-B13-C96
A7-B13-C97 A7-B13-C98 A7-B13-C99 A7-B13-C100 A7-B13-C10] A7-B13-CI02
A7-B13-C103 A7-B13-C104 A7-B13-C105 A7-B13-C106 A7-B13-C107 A7-B13-C108
A7-B13-C109 A7-B13-C110 A7-B13-C111 A7-B13-C112 A7-B13-C113 A7-B13-C114
A7-B13-C115 A7-BI3-C116 A7-B13-C117 A7-B13-C118 A7-B13-C119 A7-B13-C120
A7-B13-C121 A7-B13-C122 A7-B13-C123 A7-B13-C124 A7-B13-C125 A7-B13-C126
A7-B13-C127 A7-B13-C128 A7-B13-C129 A7-B13-C130 A7-B13-C131 A7-B13-C132
A7-B13-C133 A7-B13-C134 A7-B13-C135 A7-B13-C136 A7-B13-C137 A7-B13-C138
A7-B13-C139 A7-B13-C140 BLANK BLANK BLANK BLANK
A8-B1-C1 A8-B1-C2 A8-B1-C3 A8-B1-C4 A8-B1-C5 A8-B1-C6
A8-B1-C7 A8-B1-C8 A8-B1-C9 A8-B1-C10 A8-B1-C11 A8-B1-C12
A8-B1-C13 A8-B1-C14 A8-B1-C15 A8-BI-C16 A8-B1-C17 A8-B1-C18
A8-B1-C19 A8-B1-C20 A8-B1-C21 A8-B1-C22 A8-B1-C23 A8-B1-C24
A8-B1-C25 A8-B1-C26 A8-B1-C27 A8-B1-C28 A8-B1-C29 A8-BI-C30
A8-B1-C31 A8-B1-C32 A8-B1-C33 A8-B1-C34 A8-B1-C35 A8-B1-C36
A8-B1-C37 A8-B1-C38 A8-B1-C39 A8-B1-C40 A8-B1-C41 A8-BI-C42
A8-B1-C43 A8-B1-C44 A8-B1-C45 A8-B1-C46 A8-B1-C47 A8-B1-C48
A8-B1-C49 A8-B1-C50 A8-B1-C51 A8-B1-C52 A8-B1-C53 A8-B1-C54
A8-B1-C55 A8-B1-C56 A8-B1-C57 A8-B1-C58 A8-B1-C59 A8-B1-C60
A8-B1-C61 A8-B1-C62 A8-B1-C63 A8-B1-C64 A8-B1-C65 A8-B1-C66
A8-B1-C67 A8-B1-C68 A8-B1-C69 A8-B1-C70 A8-B1-C71 A8-B1-C72
A8-B1-C73 A8-B1-C74 A8-B1-C75 A8-B1-C76 A8-B1-C77 A8-B1-C78
A8-B1-C79 A8-B1-C80 A8-B1-C81 A8-B1-C82 A8-B1-C83 A8-B1-C84
A8-B1-C85 A8-B1-C86 A8-B1-C87 A8-B1-C88 A8-B1-C89 A8-B1-C90
A8-B1-C91 A8-B1-C92 A8-B1-C93 A8-B1-C94 A8-B1-C95 A8-B1-C96
A8-BI-C97 A8-B1-C98 A8-B1-C99 A8-B1-C100 A8-B1-C101 A8-B1-C102
A8-B1-C103 A8-B1-C104 A8-B1-C105 A8-B1-C106 A8-B1-C107 A8-B1-C108

A8-B1-C109 A8-B1-C110 A8-B1-C111 A8-B1-C112 A8-B1-C113 A8-B1-C114
A8-B1-C115 A8-B1-C116 A8-B1-C117 A8-B1-C118 A8-B1-C119 A8-B1-C120
A8-B1-C121 A8-B1-C122 A8-B1-C123 A8-BI-C124 A8-BI-C125 A8-B1-C126
A8-B1-C127 A8-B1-C128 A8-B1-C129 A8-B1-C130 A8-BI-C131 A8-B1-C132
A8-B1-C133 A8-B1-C134 A8-Bl-Ci35 A8-B1-C136 A8-B1-C137 A8-B1-C138
A8-B1 -C139 A8-B1 -C140 BLANK BLANK BLANK BLANK
A8-B2-C1 A8-B2-C2 A8-B2-C3 A8-B2-C4 A8-B2-C5 A8-B2-C6
A8-B2-C7 A8-B2-C8 A8-B2-C9 A8-B2-C10 A8-B2-C11 A8-B2-C12
A8-B2-C13 A8-B2-C14 A8-B2-C15 A8-B2-C16 A8-B2-C17 A 8-B2-C18
A8-B2-C19 A8-B2-C20 A8-B2-C21 A8-B2-C22 A8-B2-C23 A8-B2-C24
A8-B2-C25 A8-B2-C26 A8-B2-C27 A8-B2-C28 A8-B2-C29 A8-B2-C30
A8-B2-C31 A8-B2-C32 A8-B2-C33 A8-B2-C34 A8-B2-C35 A8-B2-C36
A8-B2-C37 A8-B2-C38 A8-B2-C39 A8-B2-C40 A8-B2-C41 A8-B2-C42
A8-B2-C43 A8-B2-C44 A8-B2-C45 A8-B2-C46 A8-B2-C47 A8-B2-C48
A8-B2-C49 A8-B2-C50 A8-B2-C51 A8-B2-C52 A8-B2-C53 A8-B2-C54
A8-B2-C55 A8-B2-C56 A8-B2-C57 A8-B2-C58 A8-B2-C59 A8-B2-C60
A8-B2-C6I A8-B2-C62 A8-B2-C63 A8-B2-C64 A8-B2-C65 A8-B2-C66
A8-B2-C67 A8-B2-C68 A8-B2-C69 A8-B2-C70 A8-B2-C7I A8-B2-C72
A8-B2-C73 A8-B2-C74 A8-B2-C75 A8-B2-C76 A8-B2-C77 A8-B2-C78
A8-B2-C79 A8-B2-C80 A8-B2-C81 A8-B2-C82 A8-B2-C83 A8-B2-C84
A8-B2-C85 A8-B2-C86 A8-B2-C87 A8-B2-C88 A8-B2-C89 A8-B2-C90
A8-B2-C91 A8-B2-C92 A8-B2-C93 A8-B2-C94 A8-B2-C95 A8-B2-C96
A8-B2-C97 A8-B2-C98 A8-B2-C99 A8-B2-C100 A8-B2-C101 A8-B2-C102
A8-B2-C103 A8-B2-C104 A8-B2-C105 A8-B2-C106 A8-B2-C107 A8-B2-C108
A8-B2-C109 A8-B2-C110 A8-B2-C111 A8-B2-C112 A8-B2-C113 A8-B2-C114
A8-B2-C115 A8-B2-C116 A8-B2-C117 A8-B2-C118 A8-B2-C119 A8-B2-C120
A8-B2-C121 A8-B2-C 122 A8-B2-C123 A8-B2-C124 A8-B2-C125 A8-B2-C126
A8-B2-C127 A8-B2-C128 A8-B2-C129 A8-B2-C130 A8-B2-C131 A8-B2-C132
A8-B2-C133 A8-B2-C134 A8-B2-C135 A8-B2-C136 A8-B2-C137 A8-B2-C138
A8-B2-C139 A8-B2-C140 BLANK BLANK BLANK BLANK
A8-B3-C1 A8-B3-C2 A8-B3-C3 A8-B3-C4 A8-B3-C5 A8-B3-C6
A8-B3-C7 A8-B3-C8 A8-B3-C9 A8-B3-C10 A8-B3-C11 A8-B3-C12
A8-B3-C13 A8-B3-C14 A8-B3-C15 A8-B3-C16 A8-B3-C17 A8-B3-C18
A8-B3-C19 A8-B3-C20 A8-B3-C21 A8-B3-C22 A8-B3-C23 A8-B3-C24
A8-B3-C25 A8-B3-C26 A8-B3-C27 A8-B3-C28 A8-B3-C29 A8-B3-C30
A8-B3-C3] A8-B3-C32 A8-B3-C33 A8-B3-C34 A8-B3-C35 A8-B3-C36
A8-B3-C37 A8-B3-C38 A8-B3-C39 A8-B3-C40 A8-B3-C41 A8-B3-C42

A8-B3-C43 A8-B3-C44 A8-B3-C45 A8-B3-C46 A8-B3-C47 A8-B3-C48
A8-B3-C49 A8-B3-C50 A8-B3-C51 A8-B3-C52 A8-B3-C53 A8-B3-C54
A8-B3-C55 A8-B3-C56 A8-B3-C57 A8-B3-C58 A8-B3-C59 A8-B3-C60
A8-B3-C61 A8-B3-C62 A8-B3-C63 A8-B3-C64 A8-B3-C65 A8-B3-C66
A8-B3-C67 A8-B3-C68 A8-B3-C69 A8-B3-C70 A8-B3-C71 A8-B3-C72
A8-B3-C73 A8-B3-C74 A8-B3-C75 A8-B3-C76 A8-B3-C77 A8-B3-C78
A8-B3-C79 A8-B3-C80 A8-B3-C81 A8-B3-C82 A8-B3-C83 A8-B3-C84
A8-B3-C85 A8-B3-C86 A8-B3-C87 A8-B3-C88 A8-B3-C89 A8-B3-C90
A8-B3-C91 A8-B3-C92 A8-B3-C93 A8-B3-C94 A8-B3-C95 A8-B3-C96
A8-B3-C97 A8-B3-C98 A8-B3-C99 A8-B3-CIOO A8-B3-C101 A8-B3-C102
A8-B3-C103 A8-B3-C104 A8-B3-C105 A8-B3-C106 A8-B3-C107 A8-B3-C108
A8-B3-CI09 A8-B3-C110 A8-B3-CI11 A8-B3-C112 A8-B3-C113 A8-B3-C114
A8-B3-C115 A8-B3-C116 A8-B3-C117 A8-B3-C118 A8-B3-C119 A8-B3-CI20
A8-B3-C121 A8-B3-C122 A8-B3-C123 A8-B3-C124 A8-B3-C125 A8-B3-C126
A8-B3-C127 A8-B3-C128 A8-B3-C129 A8-B3-C130 A8-B3-C131 A8-B3-C132
A8-B3-C133 A8-B3-C134 A8-B3-C135 A8-B3-C136 A8-B3-CI37 A8-B3-C138
A8-B3-C139 A8-B3-CI40 BLANK BLANK BLANK BLANK
A8-B4.C 1 A8-B4-C2 A8-B4-C3 A8-B4-C4 A8-B4-C5 A8-B4-C6
A8-B4-C7 A8-B4-C8 A8-B4-C9 A8-B4-C10 A8-B4-C11 A8-B4-CI2
A8-B4-C13 A8-B4-C14 A8-B4-C15 A8-B4-C16 A8-B4-C17 A8-B4-C18
A8-B4-C19 A8-B4-C20 A8-B4-C21 A8-B4-C22 A8-B4-C23 A8-B4-C24
A8-B4-C25 A8-B4-C26 A8-B4-C27 A8-B4-C28 A8-B4-C29 A8-B4-C30
A8-B4-C31 A8-B4-C32 A8-B4-C33 A8-B4-C34 A8-B4-C35 A8-B4-C36
A8-B4.C37 A8-B4-C38 A8-B4-C39 A8-B4-C40 A8-B4-C41 A8-B4-C42
A8-B4-C43 A8-B4-C44 A8-B4-C45 A8-B4-C46 A8-B4-C47 A8-B4-C48
A8-B4-C49 A8-B4-C50 A8-B4-C51 A8-B4-C52 A8-B4-C53 A8-B4-C54
A8-B4-C55 A8-B4-C56 A8-B4-C57 A8-B4-C58 A8-B4-C59 A8-B4-C60
A8-B4-C61 A8-B4-C62 A8-B4-C63 A8-B4-C64 A8-B4-C65 A8-B4-C66
A8-B4-C67 A8-B4-C68 A8-B4-C69 A8-B4-C70 A8-B4-C71 A8-B4-C72
A8-B4-C73 A8-B4-C74 A8-B4-C75 A8-B4-C76 A8-B4-C77 A8-B4-C78
A8-B4-C79 A8-B4-C80 A8-B4-C81 A8-B4-C82 A8-B4-C83 A8-B4-C84
A8-B4-C85 A8-B4-C86 A8-B4-C87 A8-B4-C88 A8-B4-C89 A8-B4-C90
A8-B4-C91 A8-B4-C92 A8-B4-C93 A8-B4-C94 A8-B4-C95 A8-B4-C96
A8-B4-C97 A8-B4-C98 A8-B4-C99 A8-B4-C100 A8-B4-C101 A8-B4-C102
A8-B4-C103 A8-B4-C104 A8-B4-C105 A8-B4-C106 A8-B4-C107 A8-B4-C108
A8-B4-C109 A8-B4-C110 A8-B4-C111 A8-B4-C112 A8-B4-C113 A8-B4-C114
A 8-B4-C115 A8-B4-C116 A8-B4-C117 A8-B4-C118 A8-B4-C119 A8-B4-C120

A8-B4-C121 A8-B4-C122 A8-B4-C123 A8-B4-C124 A8-B4-CI25 A8-B4-C126
A8-B4-C127 A8-B4-C128 A8-B4-C129 A8-B4-C130 A8-B4-C131 A8-B4-C132
A8-B4-C133 A8-B4-C134 A8-B4-C135 A8-B4-C136 A8-B4-C137 A8-B4-C138
A8-B4-C139 A8-B4-C140 BLANK BLANK BLANK BLANK
A8-B5-C1 A8-B5-C2 A8-B5-C3 A8-B5-C4 A8-B5-C5 A8-B5-C6
A8-B5-C7 A8-B5-C8 A8-B5-C9 A8-B5-C10 A8-B5-C11 A8-B5-C12
A8-B5-C13 A8-B5-C14 A8-B5-C15 A8-B5-C16 A8-B5-C17 A8-B5-C18
A8-B5-C19 A8-B5-C20 A8-B5-C21 A8-B5-C22 A8-B5-C23 A8-B5-C24
A8-B5-C25 A8-B5-C26 A8-B5-C27 A8-B5-C28 A8-B5-C29 A8-B5-C30
A8-B5-C31 A8-B5-C32 A8-B5-C33 A8-B5-C34 A8-B5-C35 A8-B5-C36
A8-B5-C37 A8-B5-C38 A8-B5-C39 A8-B5-C40 A8-B5-C4I A8-B5-C42
A8-B5-C43 A8-B5-C44 A8-B5-C45 A8-B5-C46 A8-B5-C47 A8-B5-C48
A8-B5-C49 A8-B5-C50 A8-B5-C51 A8-B5-C52 A8-B5-C53 A8-B5-C54
A8-B5-C55 A8-B5-C56 A8-B5-C57 A8-B5-C58 A8-B5-C59 A8-B5-C60
A8-B5-C61 A8-B5-C62 A8-B5-C63 A8-B5-C64 A8-B5-C65 A8-B5-C66
A8-B5-C67 A8-B5-C68 A8-B5-C69 A8-B5-C70 A8-B5-C71 A8-B5-C72
A8-B5-C73 A8-B5-C74 AS-B5-C75 A8-B5-C76 A8-B5-C77 A8-B5-C78
A8-B5-C79 A8-B5-C80 A8-B5-C81 A8-B5-C82 A8-B5-C83 A8-B5-C84
A8-B5-C85 A8-B5-C86 A8-B5-C87 A8-B5-C88 A8-B5-C89 A8-B5-C90
A8-B5-C91 A8-B5-C92 A8-B5-C93 A8-B5-C94 A8-B5-C95 A8-B5-C96
A8-B5-C97 A8-B5-C98 A8-B5-C99 A8-B5-C100 A8-B5-C101 A8-B5-C102
A8-B5-C103 A8-B5-C104 A8-B5-C105 A8-B5-C106 A8-B5-C107 A8-B5-C108
A8-B5-C109 A8-B5-C110 A8-B5-C111 A8-B5-C112 A8-B5-C113 A8-B5-C114
A8-B5-C115 A8-B5-C116 A8-B5-C117 A8-B5-C118 A8-B5-C119 A8-B5-C120
A8-B5-C121 A8-B5-C122 A8-B5-C123 A8-B5-C124 A8-B5-C125 A8-B5-C126
A8-B5-C127 A8-B5-C128 A8-B5-C129 A8-B5-C130 A8-B5-C131 A8-B5-C132
A8-B5-C133 A8-B5-C134 A8-B5-C135 A8-B5-C136 A8-B5-C137 A8-B5-C138
A8-B5-C139 A8-B5-C140 BLANK BLANK BLANK BLANK
A8-B6-C1 A8-B6-C2 A8-B6-C3 A8-B6-C4 A8-B6-C5 A8-B6-C6
A8-B6-C7 A8-B6-C8 A8-B6-C9 A8-B6-C10 A8-B6-C11 A8-B6-C12
A8-B6-C13 A8-B6-C14 A8-B6-C 15 A8-B6-C16 A8-B6-C17 A8-B6-C18
A8-B6-C19 A8-B6-C20 A8-B6-C21 A8-B6-C22 A8-B6-C23 A8-B6-C24
A8-B6-C25 A8-B6-C26 A8-B6-C27 A8-B6-C28 A8-B6-C29 A8-B6-C30
A8-B6-C31 A8-B6-C32 A8-B6-C33 A8-B6-C34 A8-B6-C35 A8-B6-C36
A8-B6-C37 A8-B6-C38 A8-B6-C39 A8-B6-.C40 A8-B6-C41 A8-B6-C42
A8-B6-C43 A8-B6-C44 A8-B6-C45 A8-B6-C46 A8-B6-C47 A8-B6-C48
A8-B6-C49 A8-B6-C50 A8-B6-C51 A8-B6-C52 A8-B6-C53 A8-B6-C54

A8-B6-C55 A8-B6-C56 A8-B6-C57 A8-B6-C58 A8-B6-C59 A8-B6-C60
A8-B6-C61 A8-B6-C62 A8-B6-C63 A8-B6-C64 A8-B6-C65 A8-B6-C66
A8-B6-C67 A8-B6-C68 A8-B6-C69 A8-B6-C70 A8-B6-C71 A8-B6-C72
A8-B6-C73 A8-B6-C74 A8-B6-C75 A8-B6-C76 A8-B6-C77 A8-B6-C78
A8-B6-C79 A8-B6-C80 A8-B6-C81 A8-B6-C82 A8-B6-C83 A8-B6-C84
A8-B6-C85 A8-B6-C86 A8-B6-C87 A8-B6-C88 A8-B6-C89 A8-B6-C90
A8-B6-C91 A8-B6-C92 A8-B6-C93 A8-B6-C94 A8-B6-C95 A8-B6-C96
A8-B6-C97 A8-B6-C98 A8-B6-C99 A8-B6-C100 A8-B6-C101 A8-B6-CI02
A8-B6-C103 A8-B6-C 104 A8-B6-C105 A8-B6-C106 A8-B6-C107 A8-B6-C108
A8-B6-C109 A8-B6-C110 A8-B6-C111 A8-B6-C112 A8-B6-C113 A8-B6-C114
A8-B6-C115 A8-B6-C116 A8-B6-C117 A8-B6-C118 A8-B6-C119 A8-B6-C120
A8-B6-C121 A8-B6-C122 A8-B6-C123 A8-B6-C124 A8-B6-C125 A8-B6-C126
A8-B6-C127 A8-B6-C128 A8-B6-C129 A8-B6-C 130 A8-B6-C131 A8-B6-C132
A8-B6-C133 A8-B6-C134 A8-B6-C135 A8-B6-C136 A8-B6-C137 A8-B6-C138
A8-B6-C139 A8-B6-C140 BLANK BLANK BLANK BLANK
A8-B7-C1 A8-B7-C2 A8-B7-C3 A8-B7-C4 A8-B7-C5 A8-B7-C6
A8-B7-C7 A8-B7-C8 A8-B7-C9 A8-B7-C10 A8-B7-C11 A8-B7-C12
A8-B7-C13 A8-B7-C14 A8-B7-C15 A8-B7-C16 A8-B7-C 17 A8-B7-C18
A8-B7-C19 A8-B7-C20 A8-B7-C21 A8-B7-C22 A8-B7-C23 A8-B7-C24
A8-B7-C25 A8-B7-C26 A8-B7-C27 A8-B7-C28 A8-B7-C29 A8-B7-C30
A8-B7-C31 A8-B7-C32 A8-B7-C33 A8-B7-C34 A8-B7-C35 A8-B7-C36
A8-B7-C37 A8-B7-C38 A8-B7-C39 A8-B7-C40 A8-B7-C41 A8-B7-C42
A8-B7-C43 A8-B7-C44 A8-B7-C45 A8-B7-C46 A8-B7-C47 A8-B7-C48
A8-B7-C49 A8-B7-C50 A8-B7-C51 A8-B7-C52 A8-B7-C53 A8-B7-C54
A8-B7-C55 A8-B7-C56 A8-B7-C57 A8-B7-C58 A8-B7-C59 A8-B7-C60
A8-B7-C61 A8-B7-C62 A8-B7-C63 A8-B7-C64 A8-B7-C65 A8-B7-C66
A8-B7-C67 A8-B7-C68 A8-B7-C69 A8-B7-C70 A8-B7-C71 A8-B7-C72
A8-B7-C73 A8-B7-C74 A8-B7-C75 A8-B7-C76 A8-B7-C77 A8-B7-C78
A8-B7-C79 A8-B7-C80 A8-B7-C81 A8-B7-C82 A8-B7-C83 A8-B7-C84
A8-B7-C85 A8-B7-C86 A8-B7-C87 A8-B7-C88 A8-B7-C89 A8-B7-C90
A8-B7-C91 A8-B7-C92 A8-B7-C93 A8-B7-C94 A8-B7-C95 A8-B7-C96
A8-B7-C97 A8-B7-C98 A8-B7-C99 A8-B7-C100 A8-B7-C101 A8-B7-C102
A8-B7-C103 A8-B7-C104 A8-B7-C105 A8-B7-C106 A8-B7-C107 A8-B7-C108
A8-B7-C109 A8-B7-C110 A8-B7-C111 A8-B7-C112 A8-B7-C113 A8-B7-C114
A8-B7-C115 A8-B7-C116 A8-B7-C117 A8-B7-C118 A8-B7-C119 A8-B7-C120
A8-B7-C121 A8-B7-C122 A8-B7-C123 A8-B7-C124 A8-B7-C125 A8-B7-C126
A8-B7-C127 A8-B7-C128 A8-B7-C129 A8-B7-C130 A8-B7-C131 A8-B7-C132

A8-B7-C133 A8-B7-C134 A8-B7-C135 A8-B7-CI36 A8-B7-C137 A8-B7-C138
A8-B7-C139 A8-B7-C140 BLANK BLANK BLANK BLANK
A8-B8-C1 A8-B8-C2 A8-B8-C3 A8-B8-C4 A8-B8-C5 A8-B8-C6
A8-B8-C7 A8-B8-C8 A8-B8-C9 A8-B8-C10 A8-B8-CI1 A8-B8-C12
A8-B8-C13 A8-B8-C14 A8-B8-C15 A8-B8-C16 A8-B8-C17 A8-B8-C18
A8-B8-C19 A8-B8-C20 A8-B8-C21 A8-B8-C22 A8-B8-C23 A8-B8-C24
A8-B8-C25 A8-B8-C26 A8-B8-C27 A8-B8-C28 A8-B8-C29 A8-B8-C30
A8-B8-C31 A8-B8-C32 A8-B8-C33 A8-B8-C34 A8-B8-C35 A8-B8-C36
A8-B8-C37 A8-B8-C38 A8-B8-C39 A8-B8-C40 A8-B8-C41 A8-B8-C42
A8-B8-C43 A8-B8-C44 A8-B8-C45 A8-B8-C46 A8-B8-C47 A8-B8-C48
A8-B8-C49 A8-B8-C50 A8-B8-C51 A8-B8-C52 A8-B8-C53 A8-B8-C54
A8-B8-C55 A8-B8-C56 A8-B8-C57 A8-B8-C58 A8-B8-C59 A8-B8-C60
A8-B8-C6] A8-B8-C62 A8-B8-C63 A8-B8-C64 A8-B8-C65 A8-B8-C66
A8-B8-C67 A8-B8-C68 A8-B8-C69 A8-B8-C70 A8-B8-C71 A8-B8-C72
A8-B8-C73 A8-B8-C74 A8-B8-C75 A8-B8-C76 A8-B8-C77 A8-B8-C78
A8-B8-C79 A8-B8-C80 A8-B8-C81 A8-B8-C82 A8-B8-C83 A8-B8-C84
A8-B8-C85 A8-B8-C86 A8-B8-C87 A8-B8-C88 A8-B8-C89 A8-B8-C90
A8-B8-C91 A8-B8-C92 A8-B8-C93 A8-B8-C94 A8-B8-C95 A8-B8-C96
A8-B8-C97 A8-B8-C98 A8-B8-C99 A8-B8-C100 A8-B8-C101 A8-B8-C102
A8-B8-C103 A8-B8-C104 A8-B8-C105 A8-B8-C106 A8-B8-C107 A8-B8-C108
A8-B8-C109 A8-B8-C110 A8-B8-C111 A8-B8-C112 A8-B8-C113 A8-B8-C114
A8-B8-C115 A8-B8-C116 A8-B8-C117 A8-B8-C118 A8-B8-C119 A8-B8-C120
A8-B8-C121 A8-B8-C122 A8-B8-C123 A8-B8-C124 A8-B8-C125 A8-B8-C126
A8-B8-C127 A8-B8-C128 A8-B8-C129 A8-B8-C130 A8-B8-C131 A8-B8-C132
A8-B8-C133 A8-B8-C134 A8-B8-C135 A8-B8-C136 A8-B8-C137 A8-B8-C138
A8-B8-C139 A8-B8-C140 BLANK BLANK BLANK BLANK
A8-B9-C1 A8-B9-C2 A8-B9-C3 A8-B9-C4 A8-B9-C5 A8-B9-C6
A8-B9-C7 A8-B9-C8 A8-B9-C9 A8-B9-C10 A8-B9-C11 A8-B9-C12
A8-B9-C13 A8-B9-C14 A8-B9-C15 A8-B9-Ci6 A8-B9-C17 A8-B9-C18
A8-B9-C19 A8-B9-C20 A8-B9-C21 A8-B9-C22 A8-B9-C23 A8-B9-C24
A8-B9-C25 A8-B9-C26 A8-B9-C27 A8-B9-C28 A8-B9-C29 A8-B9-C30
A8-B9-C31 A8-B9-C32 A8-B9-C33 A8-B9-C34 A8-B9-C35 A8-B9-C36
A8-B9-C37 A8-B9-C38 A8-B9-C39 A8-B9-C40 A8-B9-C41 A8-B9-C42
A8-B9-C43 A8-B9-C44 A8-B9-C45 A8-B9-C46 A8-B9-C47 A8-B9-C48
A8-B9-C49 A8-B9-C50 A8-B9-C51 A8-B9-C52 A8-B9-C53 A8-B9-C54
A8-B9-C55 A8-B9-C56 A8-B9-C57 A8-B9-C58 A8-B9-C59 A8-B9-C60
A8-B9-C61 A8-B9-C62 A8-B9-C63 A8-B9-C64 A8-B9-C65 A8-B9-C66

A8-B9-C67 A8-B9-C68 A8-B9-C69 A8-B9-C70 A8-B9-C71 A8-B9-C72
A8-B9-C73 A8-B9-C74 A8-B9-C75 A8-B9-C76 A8-B9-C77 A8-B9-C78
A8-B9-C79 A8-B9-C80 A8-B9-C81 A8-B9-C82 A8-B9-C83 A8-B9-C84
A8-B9-C85 A8-B9-C86 A8-B9-C87 A8-B9-C88 A8-B9-C89 A8-B9-C90
A8-B9-C91 A8-B9-C92 A8-B9-C93 A8-B9-C94 A8-B9-C95 A8-B9-C96
A8-B9-C97 A8-B9-C98 A8-B9-C99 A8-B9-C100 A8-B9-C101 A8-B9-C102
A8-B9-C103 A8-B9-C104 A8-B9-C105 A8-B9-C106 A8-B9-C107 A8-B9-C108
A8-B9-C109 A8-B9-C110 A8-B9-C11I A8-B9-C112 A8-B9-C113 A8-B9-C1I4
A8-B9-C115 A8-B9-C116 A8-B9-C117 A8-B9-C118 A8-B9-C119 A8-B9-C120
A8-B9-C121 A8-B9-C122 A8-B9-C123 A8-B9-C124 A8-B9-C125 A8-B9-C126
A8-B9-C127 A8-B9-C128 A8-B9-C129 A8-B9-C130 A8-B9-C131 A8-B9-C132
A8-B9-C133 A8-B9-C134 A8-B9-C135 A8-B9-C136 A8-B9-C137 A8-B9-C138
A8-B9-CI39 A8-B9-C140 BLANK BLANK BLANK BLANK
A8-B10-C1 A8-B10-C2 A8-B10-C3 A8-B10-C4 A8-B10-C5 A8-B10-C6
A8-B10-C7 A8-B10-C8 A8-B10-C9 A8-B10-C10 A8-B10-CI1 A8-B10-CI2
A8-B10-CI3 A8-B10-C14 A8-BI0-C15 A8-B10-C16 A8-B10-C17 A8-B10-C18
A8-B10-C19 A8-B10-C20 A8-B10-C21 A8-B10-C22 A8-B10-C23 A8-B10-C24
A8-B10-C25 A8-B10-C26 A8-B10-C27 A8-B10-C28 A8-B10-C29 A8-BI0-C30
A8-B10-C31 A8-B10-C32 A8-B10-C33 A8-B10-C34 A8-B10-C35 A8-B10-C36
A8-B10-C37 A8-B10-C38 A8-B10-C39 A8-B10-C40 A8-B10-C41 A8-B10-C42
A8-B10-C43 A8-B10-C44 A8-B10-C45 A8-B10-C46 A8-B10-C47 A8-B10-C48
A8-B10-C49 A8-B10-C50 A8-B10-C51 A8-B10-C52 A8-B10-C53 A8-B10-C54
A8-B10-C55 A8-B10-C56 A8-B10-C57 A8-B10-C58 A8-B10-C59 A8-B10-C60
A8-B10-C61 A8-B10-C62 A8-B10-C63 A8-B10-C64 A8-B10-C65 A8-B10-C66
A8-B10-C67 A8-B10-C68 A8-B10-C69 A8-B10-C70 A8-B10-C71 A8-B10-C72
A8-B10-C73 A8-B10-C74 A8-B10-C75 A8-B10-C76 A8-B10-C77 A8-B10-C78
A8-B10-C79 A8-B10-C80 A8-B10-C81 A8-B10-C82 A8-B10-C83 A8-B10-C84
A8-B10-C85 A8-B10-C86 A8-B10-C87 A8-B10-C88 A8-B10-C89 A8-BI0-C90
A8-B10-C91 A8-B10-C92 A8-B10-C93 A8-B10-C94 A8-B10-C95 A8-B10-C96
A8-B10-C97 A8-B10-C98 A8-B10-C99 A8-B10-C100 A8-B10-C101 A8-B10-C102
A8-B10-CI03 A8-B10-CI04 A8-B10-C105 A8-B10-C106 A8-B10-C107 A8-B10-C108
A8-B10-C109 A8-B10-C110 A8-B10-CI11 A8-B10-C1I2 A8-B10-C113 A8-B10-C1I4
A8-B10-CI15 A8-B10-C116 A8-B10-C117 A8-B10-C118 A8-B10-C119 A8-B10-C120
A8-B10-C121 A8-B10-C122 A8-B10-C123 A8-B10-CI24 A8-B10-CI25 A8-B10-C126
A8-B10-C127 A8-B10-C128 A8-B10-CI29 A8-B10-C130 A8-B10-C131 A8-B10-C132
A8-B10-C133 A8-B10-C134 A8-B10-C135 A8-B10-C136 A8-B10-C137 A8-B10-C138
A8-BI0-C139 A8-B10-C140 BLANK BLANK BLANK BLANK

A8-B11 -C1 A8-B11 -C2 A8-B11 -C3 A8-B11 -C4 A8-B11 -C5 A8-B11 -C6
A8-B11-C7 A8-B11-C8 A8--Bn-C9 A8-B1I-C10 A8-B11-C11 A8-B11-CI2
A8-B1I-C13 A8-B11-C14 A8-B11-C15 A8-B11-C16 A8-B11-C17 A8-B11-C18
A8-B11-C19 A8-B11-C20 A8-B11-C21 A8-B11-C22 A8-BI1-C23 A8-B11-C24
A8-B11-C25 A8-B11-C26 A8-B11-C27 A8-B11-C28 A8-B11-C29 A8-B11-C30
A8-B11-C31 A8-B11-C32 A8-B11-C33 A8-B11-C34 A8-B11-C35 A8-B11-C36
A8-B11-C37 A8-B11-C38 A8-B11-C39 A8-B11-C40 A8-B11-C41 A8-B11-C42
A8-BII-C43 A8-B 11-C44 A8-B11-C45 A8-B11-C46 A8-B11-C47 A8-B11-C48
A8-B11-C49 A8-B11-C50 A8-B11 -C51 A8-B11-C52 A8-B11-C53 A8-B11-C54
A8-B11-C55 A8-BI1-C56 A8-B11-C57 A8-B11-C58 A8-B11-C59 A8-B11-C60
A8-B11-C61 A8-B11-C62 A8-B11-C63 A8-B11-C64 A8-B11-C65 A8-B11-C66
A8-B11-C67 A8-B11-C68 A8-B11-C69 A8-B11-C70 A8-B11 -C71 A8-B11-C72
A8-B11-C73 A8-B1KC74 A8-B11-C75 A8-B11-C76 A8-B11-C77 A8-B11-C78
A8-B11-C79 A8-B11-C80 A8-B11-C81 AS-Bl 1-C82 A8-B11-C83 A8-B11-C84
A8-B11-C85 A8-B11-C86 A8-B11-C87 A8-B11-C88 A8-B11-C89 A8-B11-C90
A8-B11 -C91 A8-B11-C92 A8-B11-C93 A8-B11-C94 A8-B11-C95 A8-B11-C96
A8-B11-C97 A8-B11-C98 A8-B11-C99 A8-B11 -CI 00 A8-B11 -C101 A8-B11 -C102
A8-B11-C103 A8-B11-C104 A8-B11-C105 A8-B11-C106 A8-B11-C107 A8-B11-C108
A8-B11-C109 A8-B11-C110 A8-B11-C111 A8-B11-C112 AS-Bll-ClB A8-B11-C114
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A8-B11-C127 A8-B11-C128 A8-B11-C129 A8-B11-C130 A8-B11-C131 A8-B11-C132
A8-B11-C133 A8-B11-C134 A8-B11-C135 A8-B11-C136 A8-B11-C137 A8-B11-C138
A8-B11-C139 A8-B11-C140 BLANK BLANK BLANK BLANK
A8-B12-C1 A8-B12-C2 A8-B12-C3 A8-B12-C4 A8-B12-C5 A8-B12-C6
A8-B12-C7 A8-B12-C8 A8-B12-C9 A8-B12-C 10 A8-B12-C 11 A8-B12-Cl 2
A8-B12-CI3 A8-B12-C14 A8-B12-C15 A8-B12-C16 A8-B12-C17 A8-B12-C18
A8-B12-C 19 A8-B12-C20 A8-B12-C21 A8-B12-C22 A8-B12-C23 A8-B12-C24
A8-B12-C25 A8-B12-C26 A8-B12-C27 A8-B12-C28 A8-B12-C29 A8-B12-C30
A8-B12-C31 A8-B12-C32 A8-B12-C33 A8-B12-C34 A8-B12-C35 A8-B12-C36
A8-B12-C37 A8-B12-C3 8 A8-B12-C39 A8-B12-C40 A8-B12-C41 A8-B12-C42
A8-B12-C43 A8-B12-C44 A8-B12-C45 A8-B12-C46 A8-B12-C47 A8-B12-C48
A8-B12-C49 A8-B12-C50 A8-B12-C51 A8-B12-C52 A8-B12-C53 A8-B12-C54
A8-B12-C55 A8-B12-C56 A8-B12-C57 A8-B12-C58 A8-B12-C59 A8-B12-C60
A8-B12-C61 A8-B12-C62 A8-B12-C63 A8-B12-C64 A8-B12-C65 A8-B12-C66
A8-B12-C67 A8-B12-C68 A8-B12-C69 A8-B12-C70 A8-B12-C71 A8-B12-C72
A8-B12-C73 A8-B12-C74 A8-B12-C75 A8-B12-C76 A8-B12-C77 A8-B12-C78

A8-B12-C79 A8-B12-C80 A8-B12-C81 A8-B12-C82 A8-B12-C83 A8-B12-C84
A8-B 12-C85 A8-B12-C86 A8-B12-C87 A8-B12-C88 A8-B12-C89 A8-B12-C90
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A8-B12-C 139 A8-B12-C 140 BLANK BLANK BLANK BLANK
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A8-B13-C7 A8-B13-C8 A8-B13-C9 A8-B H-C10 A8-B13-C11 A8-B13-C12
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A8-B13-C37 A8-B13-C38 A8-B13-C39 A8-B13-C40 A8-B13-C41 A8-B13-C42
A8-B13-C43 A8-B13-C44 A8-B13-C45 A8-B13-C46 A8-BI3-C47 A8-B13-C48
A8-B13-C49 A8-B13-C50 A8-B13-C51 A8-B13-C52 A8-BI3-C53 A8-B13-C54
A8-B13-C55 A8-B13-C56 A8-B13-C57 A8-B13-C58 A8-B13-C59 A8.-B13-C60
A8-B13-C61 A8-B13-C62 A8-B13-C63 A8-B13-C64 A8-B13-C65 A8-B13-C66
A8-B13-C67 A8-B13-C68 A8-B13-C69 A8-B13-C70 A8-B13-C71 A8-B13-C72
A8-B13-C73 A8-B13-C74 A8-B13-C75 A8-B13-C76 A8-B13-C77 A8-B13-C78
A8-B13-C79 A8-B13-C80 A8-B13-C81 A8-B13-C82 A8-B13-C83 A8-B13-C84
A8-B13-C85 A8-B13-C86 A8-B13-C87 A8-B13-C88 A8-B13-C89 A8-B13-C90
A8-B13-C9I A8-B13-C92 A8-B13-C93 A8-B13-C94 A8-B13-C95 A8-B13-C96
A8-B13-C97 A8-B13-C98 A8-B13-C99 A8-B13-C 100 A8-B13-C 101 A8-B13-C 102
A8-B13-C103 A8-B13-CI04 A8-B13-C105 A8-B13-C106 A8-B13-C107 A8-BI3-C108
A8-B13-C109 A8-B13-CI10 A8-BI3-C1I1 A8-B13-C112 A8-B13-C113 A8-B13-C114
A8-B13-Cn5 A8-B13-C1I6 A8-B13-C117 A8-B13-Cn8 A8-B13-C119 A8-B13-C120
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A8-B13-C133 A8-B13-C134 A8-B13-C135 A8-B13-C136 A8-B13-C137 A8-B13-C138
A8-B13-C139 A8-B13-CI40 BLANK BLANK BLANK BLANK
A9-B1 -C1 A9-B1 -C2 A9-B1 -C3 A9-B1 -C4 A9-B1 -C5 A9-B1 -C6
A9-B1 -C7 A9-B1 -C8 A9-B1 -C9 A9-B1 -C10 A9-BI -C11 A9-B1 -C12

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A9-B1-C19 A9-B1-C20 A9-B1-C21 A9-B1-C22 A9-B1-C23 A9-B1-C24
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A9-B1-C43 A9-B1-C44 A9-B1-C45 A9-B1-C46 A9-B1-C47 A9-B1-C48
A9-B1-C49 A9-B1-C50 A9-B1-C51 A9-B1-C52 A9-B1-C53 A9-B1-C54
A9-BI-C55 A9-B1-C56 A9-B1-C57 A9-B1-C58 A9-B1-C59 A9-B1-C60
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A9-B1-C103 A9-B1-C104 A9-B1-C105 A9-B1-C106 A9-B1-C107 A9-B1-C108
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A9-B1-C121 A9-B1-C122 A9-B1-C123 A9-B1-C124 A9-B1-C125 A9-B1-C126
A9-B1-C127 A9-B1-C128 A9-B1-C129 A9-B1-C130 A9-B1-C131 A9-BI-CI32
A9-B1-C133 A9-B1-C134 A9-B1-C135 A9-B1-C136 A9-B1-C137 A9-B1-C138
A9-B1-C139 A9-B1-C140 BLANK BLANK BLANK BLANK
A9-B2-C1 A9-B2-C2 A9-B2-C3 A9-B2-C4 A9-B2-C5 A9-B2-C6
A9-B2-C7 A9-B2-C8 A9-B2-C9 A9-B2-C10 A9-B2-Cn A9-B2-C12
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A9-B2-C43 A9-B2-C44 A9-B2-C45 A9-B2-C46 A9-B2-C47 A9-B2-C48
A9-B2-C49 A9-B2-C50 A9-B2-C51 A9-B2-C52 A9-B2-C53 A9-B2-C54
A9-B2-C55 A9-B2-C56 A9-B2-C57 A9-B2-C58 A9-B2-C59 A9-B2-C60
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A9-B2-C67 A9-B2-C68 A9-B2-C69 A9-B2-C70 A9-B2-C71 A9-B2-C72
A9-B2-C73 A9-B2-C74 A9-B2-C75 A9-B2-C76 A9-B2-C77 A9-B2-C78
A9-B2-C79 A9-B2-C80 A9-B2-C81 A9-B2-C82 A9-B2-C83 A9-B2-C84
A9-B2-C85 A9-B2-C86 A9-B2-C87 A9-B2-C88 A9-B2-C89 A9-B2-C90

A9-B2-C91 A9-B2-C92 A9-B2-C93 A9-B2-C94 A9-B2-C95 A9-B2-C96
A9-B2-C97 A9-B2-C98 A9-B2-C99 A9-B2-C100 A9-B2-C101 A9-B2-C102
A9-B2-C103 A9-B2-C104 A9-B2-C105 A9-B2-C106 A9-B2-C107 A9-B2-C108
A9-B2-C109 A9-B2-C110 A9-B2-C111 A9-B2-C112 A9-B2-C113 A9-B2-C114
A9-B2-C115 A9-B2-C116 A9-B2-C117 A9-B2-C118 A9-B2-C119 A9-B2-C120
A9-B2-C121 A9-B2-C122 A9-B2-C 123 A9-B2-C124 A9-B2-C125 A9-B2-C126
A9-B2-C127 A9-B2-C 128 A9-B2-C129 A9-B2-C130 A9-B2-C131 A9-B2-C132
A9-B2-C133 A9-B2-C134 A9-B2-C135 A9-B2-C136 A9-B2-C137 A9-B2-C138
A9-B2-C139 A9-B2-C140 BLANK BLANK BLANK BLANK
A9-B3-C1 A9-B3-C2 A9-B3-C3 A9-B3-C4 A9-B3-C5 A9-B3-C6
A9-B3-C7 A9-B3-C8 A9-B3-C9 A9-B3-C10 A9-B3-C11 A9-B3-C12
A9-B3-C13 A9-B3-C 14 A9-B3-C15 A9-B3-C16 A9-B3-C17 A9-B3-C18
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A9-B3-C31 A9-B3-C32 A9-B3-C33 A9-B3-C34 A9-B3-C35 A9-B3-C36
A9-B3-C37 A9-B3-C38 A9-.B3-C39 A9-B3-C40 A9-B3-C41 A9-B3-C42
A9-B3-C43 A9-B3-C44 A9-B3-C45 A9-B3-C46 A9-B3-C47 A9-B3-C48
A9-B3-C49 A9-B3-C50 A9-B3-C51 A9-B3-C52 A9-B3-C53 A9-B3-C54
A9-B3-C55 A9-B3-C56 A9-B3-C57 A9-B3-C58 A9-B3-C59 A9-B3-C60
A9-B3-C61 A9-B3-C62 A9-B3-C63 A9-B3-C64 A9-B3-C65 A9-B3-C66
A9-B3-C67 A9-B3-C68 A9-B3-C69 A9-B3-C70 A9-B3-C71 A9-B3-C72
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A9-B3-C97 A9-B3-C98 A9-B3-C99 A9-B3-C100 A9-B3-C101 A9-B3-C102
A9-B3-C103 A9-B3-C104 A9-B3-C105 A9-B3-C106 A9-B3-C107 A9-B3-C108
A9-B3-C109 A9-B3-C110 A9-B3-C111 A9-B3-C112 A9-B3-CI13 A9-B3-C114
A9-B3-C115 A9-B3-C116 A9-B3-C117 A9-B3-C118 A9-B3-C119 A9-B3-C120
A9-B3-C121 A9-B3-C122 A9-B3-C123 A9-B3-C124 A9-B3-C125 A9-B3-C126
A9-B3-C127 A9-B3-C128 A9-B3-C129 A9-B3-C130 A9-B3-C131 A9-B3-C132
A9-B3-C133 A9-B3-C134 A9-B3-C135 A9-B3-C136 A9-B3-C137 A9-B3-C138
A9-B3-C139 A9-B3-C140 BLANK BLANK BLANK BLANK
A9-B4-C1 A9-B4-C2 A9-B4-C3 A9-B4-C4 A9-B4-C5 A9-B4-C6
A9-B4-C7 A9-B4-C8 A9-B4-C9 A9-B4-C10 A9-B4-C11 A9-B4-C12
A9-B4-C13 A9-B4-C 14 A9-B4-C15 A9-B4-C16 A9-B4-C17 A9-B4-C 18
A9-B4-C19 A9-B4-C20 A9-B4-C21 A9-B4-C22 A9-B4-C23 A9-B4-C24

A9-B4-C25 A9-B4-C26 A9-B4-C27 A9-B4-C28 A9-B4-C29 A9-B4-C30
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A9-B4-C43 A9-B4-C44 A9-B4-C45 A9-B4-C46 A9-B4-C47 A9-B4-C48
A9-B4-C49 A9-B4-C50 A9-B4-C51 A9-B4-C52 A9-B4-C53 A9-B4-C54
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A9-B4-C91 A9-B4-C92 A9-B4-C93 A9-B4-C94 A9-B4-C95 A9-B4-C96
A9-B4-C97 A9-B4-C98 A9-B4-C99 A9-B4-C100 A9-B4-C101 A9-B4-C102
A9-B4-C103 A9-B4-C104 A9-B4-C105 A9-B4-C106 A9-B4-C107 A9-B4-C108
A9-B4-C109 A9-B4-C110 A9-B4-C111 A9-B4-C112 A9-B4-C113 A9-B4-C114
A9-B4-C115 A9-B4-C116 A9-B4-C117 A9-B4-C118 A9-B4-C119 A9-B4-C120
A9-B4-C121 A9-B4-C122 A9-B4-C123 A9-B4-C124 A9-B4-C125 A9-B4-C126
A9-B4-C127 A9-B4-C128 A9-B4-C129 A9-B4-C130 A9-B4-C131 A9-B4-C132
A9-B4-CI33 A9-B4-C134 A9-B4-C135 A9-B4-C136 A9-B4-C137 A9-B4-CI38
A9-B4-C139 A9-B4-C 140 BLANK BLANK BLANK BLANK
A9-B5-CI A9-B5-C2 A9-B5-C3 A9-B5-C4 A9-B5-C5 A9-B5-C6
A9-B5-C7 A9-B5-C8 A9-B5-C9 A9-B5-C10 A9-B5-C11 A9-B5-C12
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A9-B5-C37 A9-B5-C38 A9-B5-C39 A9-B5-C40 A9-B5-C41 A9-B5-C42
A9-B5-C43 A9-B5-C44 A9-B5-C45 A9-B5-C46 A9-B5-C47 A9-B5-C48
A9-B5-C49 A9-B5-C50 A9-B5-C51 A9-B5-C52 A9-B5-C53 A9-B5-C54
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A9-B5-C79 A9-B5-C80 A9-B5-C81 A9-B5-C82 A9-B5-C83 A9-B5-C84
A9-B5-C85 A9-B5-C86 A9-B5-C87 A9-B5-C88 A9-B5-C89 A9-B5-C90
A9-B5-C91 A9-B5-C92 A9-B5-C93 A9-B5-C94 A9-B5-C95 A9-B5-C96
A9-B5-C97 A9-B5-C98 A9-B5-C99 A9-B5-C100 A9-B5-C101 A9-B5-C102

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A9-B5-C133 A9-B5-C134 A9-B5-C135 A9-B5-C136 A9-B5-C137 A9-B5-C138
A9-B5-C]39 A9-B5-C140 BLANK BLANK BLANK BLANK
A9-B6-C1 A9-B6-C2 A9-B6-C3 A9-B6-C4 A9-B6-C5 A9-B6-C6
A9-B6-C7 A9-B6-C8 A9-B6-C9 A9-B6-C10 A9-B6-C11 A9-B6-C12
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A9-B6-C55 A9-B6-C56 A9-B6-C57 A9-B6-C58 A9-B6-C59 A9-B6-C60
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A9-B6-C103 A9-B6-C104 A9-B6-C 105 A9-B6-C106 A9-B6-C107 A9-B6-C108
A9-B6-C109 A9-B6-C110 A9-B6-C111 A9-B6-C112 A9-B6-C113 A9-B6-C114
A9-B6-C115 A9-B6-C116 A9-B6-C117 A9-B6-C118 A9-B6-C119 A9-B6-C120
A9-B6-C 121 A9-B6-C 122 A9-B6-C123 A9-B6-C124 A9-B6-C125 A9-B6-C126
A9-B6-C127 A9-B6-C128 A9-B6-C129 A9-B6-C130 A9-B6-C 131 A9-B6-C132
A9-B6-C133 A9-B6-C134 A9-B6-C135 A9-B6-C136 A9-B6-C137 A9-B6-C138
A9-B6-C139 A9-B6-C140 BLANK BLANK BLANK BLANK
A9-B7-C1 A9-B7-C2 A9-B7-C3 A9-B7-C4 A9-B7-C5 A9-B7-C6
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A9-B7-C31 A9-B7-C32 A9-B7-C33 A9-B7-C34 A9-B7-C35 A9-B7-C36

A9-B7-C37 A9-B7-C38 A9-B7-C39 A9-B7-C40 A9-B7-C41 A9-B7-C42
A9-B7-C43 A9-B7-C44 A9-B7-C45 A9-B7-C46 A9-B7-C47 A9-B7-C48
A9-B7-C49 A9-B7-C50 A9-B7-C51 A9-B7-C52 A9-B7-C53 A9-B7-C54
A9-B7-C55 A9-B7-C56 A9-B7™C57 A9-B7-C58 A9-B7-C59 A9-B7-C60
A9-B7-C61 A9-B7-C62 A9-B7-C63 A9-B7-C64 A9-B7-C65 A9-B7-C66
A9-B7-C67 A9-B7-C68 A9-B7-C69 A9-B7-C70 A9-B7-C7I A9-B7-C72
A9-B7-C73 A9-B7-C74 A9-B7-C75 A9-B7-C76 A9-B7-C77 A9-B7-C78
A9-B7-C79 A9-B7-C80 A9-B7-C81 A9-B7-C82 A9-B7-C83 A9-B7-C84
A9-B7-C85 A9-B7-C86 A9-B7-C87 A9-B7-C88 A9-B7-C89 A9-B7-C90
A9-B7-C91 A9-B7-C92 A9-B7-C93 A9-B7-C94 A9-B7-C95 A9-B7-C96
A9-B7-C97 A9-B7-C98 A9-B7-C99 A9-B7-C100 A9-B7-C101 A9-B7-C102
A9-B7-C103 A9-B7-C104 A9-B7-C105 A9-B7-C106 A9-B7-C107 A9-B7-C108
A9-B7-C109 A9-B7-C110 A9-B7-C111 A9-B7-C112 A9-B7-C113 A9-B7-C114
A9-B7-C115 A9-B7-C116 A9-B7-C117 A9-B7-C118 A9-B7-C119 A9-B7-C120
A9-B7-C121 A9-B7-C122 A9-B7-C123 A9-B7-C124 A9-B7-C125 A9-B7-C126
A9-B7-C 127 A9-B7-C128 A9-B7-C129 A9-B7-C130 A9-B7-C131 A9-B7-C132
A9-B7-C133 A9-B7-C134 A9-B7-C135 A9-B7-C136 A9-B7-C137 A9-B7-C138
A9-B7-C139 A9-B7-C140 BLANK BLANK BLANK BLANK
A9-B8-C1 A9-B8-C2 A9-B8-C3 A9-B8-C4 A9-B8-C5 A9-B8-C6
A9-B8-C7 A9-B8-C8 A9-B8-C9 A9-B8-C10 A9-B8-C11 A9-B8-C12
A9-B8-C13 A9-B8-C14 A9-B8-C15 A9-B8-C16 A9-B8-C17 A9-B8-C18
A9-B8-C 19 A9-B8-C20 A9-B8-C21 A9-B8-C22 A9-B8-C23 A9-B8-C24
A9-B8-C25 A9-B8-C26 A9-B8-C27 A9-B8-C28 A9-B8-C29 A9-B8-C30
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A9-B8-C37 A9-B8-C38 A9-B8-C39 A9-B8-C40 A9-B8-C41 A9-B8-C42
A9-B8-C43 A9-B8-C44 A9-B8-C45 A9-B8-C46 A9-B8-C47 A9-B8-C48
A9-B8-C49 A9-B8-C50 A9-B8-C51 A9-B8-C52 A9-B8-C53 A9-B8-C54
A9-B8-C55 A9-B8-C56 A9-B8-C57 A9-B8-C58 A9-B8-C59 A9-B8-C60
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A9-B8-C85 A9-B8-C86 A9-B8-C87 A9-B8-C88 A9-B8-C89 A9-B8-C90
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A9-B8-C103 A9-B8-C104 A9-B8-C105 A9-B8-C106 A9-B8-C 107 A9-B8-C108
A9-B8-C109 A9-B8-C110 A9-B8-C111 A9-B8-C112 A9-B8-C113 A9-B8-C114

A9-B8-C115 A9-B8-C116 A9-B8-C117 A9-B8-C118 A9-B8-C119 A9-B8-C120
A9-B8-C121 A9-B8-C122 A9-B8-C123 A9-B8-C 124 A9-B8-C125 A9-B8-C126
A9-B8-C127 A9-B8-C128 A9-B8-C129 A9-B8-C130 A9-B8-C131 A9-B8-C 132
A9-B8-C133 A9-B8-C134 A9-B8-C135 A9-B8-C136 A9-B8-C137 A9-B8-C138
A9-B8-C139 A9-B8-C140 BLANK BLANK BLANK BLANK
A9-B9-C1 A9-B9-C2 A9-B9-C3 A9-B9-C4 A9-B9-C5 A9-B9-C6
A9-B9-C7 A9-B9-C8 A9-B9-C9 A9-B9-C10 A9-B9-C11 A9-B9-C12
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A9-B9-C37 A9-B9-C38 A9-B9-C39 A9-B9-C40 A9-B9-C41 A9-B9-C42
A9-B9-C43 A9-B9-C44 A9-B9-C45 A9-B9-C46 A9-B9-C47 A9-B9-C48
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A9-B9-C85 A9-B9-C86 A9-B9-C87 A9-B9-C88 A9-B9-C89 A9-B9-C90
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A9-B9-C133 A9-B9-C134 A9-B9-C135 A9-B9-C136 A9-B9-C137 A9-B9-C138
A9-B9-C139 A9-B9-C140 BLANK BLANK BLANK BLANK
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A9-B10-C37 A9-B10-C3 8 A9-B10-C39 A9-B10-C40 A9-B10-C41 A9-B10-C42
A9-B10-C43 A9-B10-C44 A9-B10-C45 A9-B10-C46 A9-B 10-C47 A9-B10-C48

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A9-B10-C 109 A9-B10-C 110 A9-B10-C 111 A9-B10-C 112 A9-B10-C 113 A9-B10-C 114
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A9-B10-C 139 A9-B10-C 140 BLANK BLANK BLANK BLANK
A9-B11 -C1 A9-B11 -C2 A9-B11 -C3 A9-B11 -C4 A9-B11 -C5 A9-B11 -C6
A9-B11 -C7 A9-B11 ™C8 A9-B11 -C9 A9-B11 -C10 A9-B11 -C11 A9-B11 -C12
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A9-B11-C121 A9-B11-C122 A9-B11-C123 A9-B11-C124 A9-B11-C125 A9-B11-C126

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A9-B11-C133 A9-B11-C134 A9-B11-C135 A9-B11-C136 A9-B11-C137 A9-B11-C138
A9-B11-C139 A9-B11-C140 BLANK BLANK BLANK BLANK
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A9-B12-C37 A9-B12-C3 8 A9-B12-C39 A9-B12-C40 A9-B12-C41 A9-B12-C42
A9-B12-C43 A9-B12-C44 A9-B12-C45 A9-B12-C46 A9-B12-C47 A9-B12-C48
A9-B12-C49 A9-B12-C50 A9-B12-C51 A9-B12-C52 A9-B12-C53 A9-B12-C54
A9-B12-C55 A9-B12-C56 A9-B12-C57 A9-B12-C58 A9-B12-C59 A9-B12-C60
A9-B12-C61 A9-B12-C62 A9-B12-C63 A9-B12-C64 A9-B12-C65 A9-B12-C66
A9-B12-C67 A9-B12-C68 A9-B12-C69 A9-B12-C70 A9-B12-C71 A9-B12-C72
A9-B12-C73 A9-B12-C74 A9-B12-C75 A9-B12-C76 A9-B12-C77 A9-B12-C78
A9-B12-C79 A9-B12-C80 A9-B12-C81 A9-B12-C82 A9-B12-C83 A9-B12-C84
A9-B12-C85 A9-B12-C86 A9-B12-C87 A9-B12-C88 A9-B12-C89 A9-B12-C90
A9-B12-C91 A9-B12-C92 A9-B12-C93 A9-B12-C94 A9-B12-C95 A9-B12-C96
A9-B12-C97 A9-B12-C98 A9-B12-C99 A9-B12-C 100 A9-B12-C 101 A9-B12-C 102
A9-B12-C 103 A9-B12-C 104 A9-B12-C 105 A9-B12-C 106 A9-B12-C 107 A9-B12-C 108
A9-B12-C 109 A9-B12-C 110 A9-B12-C 111 A9-B12-C 112 A9-B12-C 113 A9-B12-C 114
A9-B12-C 115 A9-B12-C 116 A9-B12-C 117 A9-B12-C 118 A9-B12-C 119 A9-B12-C 120
A9-B12-C 121 A9-B12-C 122 A9-B12-C 123 A9-B12-C 124 A9-B12-C 125 A9-B12-C 126
A9-B12-C 127 A9-B12-C 128 A9-B12-C 129 A9-B12-C 130 A9-B12-C 131 A9-B12-C 132
A9-B12-C133 A9-B12-C134 A9-B12-C135 A9-B12-C136 A9-B12-C137 A9-B12-C138
A9-B12-C 139 A9-B12-C 140 BLANK BLANK BLANK BLANK
A9-B13-C1 A9-B13-C2 A9-B13-C3 A9-B13-C4 A9-B13-C5 A9-B13-C6
A9-B13-C7 A9-B13-C8 A9-B13-C9 A9-B13-C10 A9-B13-C11 A9-B13-C12
A9-B13-C13 A9-B13-C14 A9-B13-C15 A9-B13-C16 A9-B13-C17 A9-B13-C18
A9-B13-C19 A9-B13-C20 A9-B13-C21 A9-B13-C22 A9-B13-C23 A9-B13-C24
A9-B13-C25 A9-B13-C26 A9-B13-C27 A9-B13-C28 A9-B13-C29 A9-B13-C30
A9-B13-C31 A9-B13-C32 A9-B13-C33 A9-B13-C34 A9-B13-C35 A9-B13-C36
A9-B13-C37 A9-B13-C38 A9-B13-C39 A9-B13-C40 A9-B13-C41 A9-B13-C42
A9-B13-C43 A9-B13-C44 A9-B13-C45 A9-B13-C46 A9-B13-C47 A9-B13 -C48
A9-B13-C49 A9-B13-C50 A9-B13-C51 A9-B13-C52 A9-B13-C53 A9-B13-C54
A9-B13-C55 A9-B13-C56 A9-B13-C57 A9-B13-C58 A9-B13-C59 A9-B13-C60

A9-B13-C61 A9-B13-C62 A9-B13-C63 A9-B13-C64 A9-B13-C65 A9-BI3-C66
A9-B13-C67 A9-B13-C68 A9-B13-C69 A9-B13-C70 A9-B13-C71 A9-B13-C72
A9-B13-C73 A9-B13-C74 A9-B13-C75 A9-B13-C76 A9-B13-C77 A9-B13-C78
A9-B13-C79 A9-B13-C80 A9-B13-C81 A9-B13-C82 A9-B13-C83 A9-B13-C84
A9-B13-C85 A9-B13-C86 A9-B13-C87 A9-B13-C88 A9-B13-C89 A9-B13-C90
A9-B13-C91 A9-B13-C92 A9-B13-C93 A9-B13-C94 A9-B13-C95 A9-B13-C96
A9-B13-C97 A9-B13-C98 A9-B13-C99 A9-B13-C100 A9-B13-C101 A9-B13-C102
A9-B13-C103 A9-B13-C104 A9-BI3-C105 A9-B13-C106 A9-B13-C107 A9-B13-C108
A9-B13-C109 A9-B13-C110 A9-B13-C111 A9-B13-C112 A9-B13-C113 A9-B13-CI14
A9-B13-C115 A9-BI3-C116 A9-B13-C117 A9-B13-C118 A9-B13-C119 A9-B13-C120
A9-B13-CI21 A9-B13-C122 A9-B13-CI23 A9-B13-C124 A9-B13-C125 A9-B13-C126
A9-B13-C127 A9-B13-C128 A9-B13-C129 A9-B13-C130 A9-B13-C131 A9-B13-C132
A9-B13-C133 A9-B13-C134 A9-B13-C135 A9-B13-C136 A9-B13-C137 A9-B13-C138
A9-B13-C139 A9-B13-C140 BLANK BLANK BLANK BLANK
AlO-Bl-Cl A10-B1-C2 A10-B1-C3 A10-B1-C4 A10-B1-C5 A10-B1-C6
A10-B1-C7 A10-B1-C8 A10-B1-C9 AIO-BI-CIO AlO-Bl-Cll A10-B1-C12
A10-B1-C13 A10-B1-C14 A10-B1-C15 A10-B1-C16 A10-BI-C17 A10-B1-C18
A10-B1-C19 A10-B1-C20 A10-B1-C21 A10-B1-C22 A10-B1-C23 A10-B1-C24
A10-B1-C25 A10-B1-C26 A10-BI-C27 A10-BI-C28 A10-B1-C29 A10-B1-C30
A10-B1-C31 A10-B1-C32 A10-BI-C33 A10-BNC34 A10-B1-C35 A10-B1-C36
AI0-B1-C37 A10-B1-C38 A10-B1-C39 A10-B1-C40 A10-B1-C41 A10-B1-C42
AI0-B1-C43 A10-B1-C44 A10-BI-C45 A10-B1-C46 A10-B1-C47 A10-B1-C48
A10-B1-C49 A10-B1-C50 A10-B1-C51 A10-B1-C52 A10-B1-C53 A10-B1-C54
A10-B1-C55 A10-B1-C56 A10-B1-C57 A10-B1-C58 A10-B1-C59 A10-B1-C60
A10-B1-C61 A10-B1-C62 A10-B1-C63 A10-B1-C64 A10-B1-C65 A10-B1-C66
A10-B1-C67 A10-B1-C68 A10-B1-C69 A10-B1-C70 A10-B1-C71 A10-B1-C72
A10-B1-C73 A10-B1-C74 A10-B1-C75 A10-B1-C76 A10-B1-C77 A10-B1-C78
A10-B1-C79 A10-B1-C80 A10-B1-C81 A10-B1-C82 A10-B1-C83 A10-B1-C84
A10-B1-C85 A10-B1-C86 A10-B1-C87 A10-B1-C88 AI0-B1-C89 A10-B1-C90
A10-B1-C91 A10-B1-C92 A10-B1-C93 AI0-B1-C94 A10-B1-C95 A10-B1-C96
A10-B1-C97 A10-B1-C98 A10-B1-C99 AlO-Bl-ClOO AlO-Bl-ClOl A10-B1-C102
A10-B1-C103 A10-B1-C104 A10-B1-C105 A10-B1-C106 A10-B1-C107 A10-B1-CI08
A10-B1-C109 AlO-Bl-CllO AlO-Bl-Clll A10-B1-C112 A10-B1-C113 A10-B1-C114
A10-B1-C115 A10-B1-C116 A10-B1-C117 AI0-B1-C118 A10-BI-C119 A10-B1-C120
A10-BI-C121 A10-B1-C122 A10-B1-C123 A10-B1-C124 A10-B1-C125 A10-B1-C126
A10-BI-C127 A10-B1-C128 A10-B1-C129 A10-B1-C130 A10-B1-C131 A10-B1-C132
A10-B1-C133 A10-B1-C134 A10-B1-C135 A10-B1-C136 A10-B1-C137 A10-B1-C138

A10-B1-C139 A10-B1-CI40 BLANK BLANK BLANK BLANK
A10-B2-C1 A10-B2-C2 A10-B2-C3 A10-B2-C4 A10-B2-C5 A10-B2-C6
A10-B2-C7 A10-B2-C8 A10-B2-C9 A10-B2-C10 A10-B2-C11 A10-B2-C12
A10-B2-C 13 A10-B2-C14 A10-B2-C15 A10-B2-C 16 A10-B2-C17 A10-B2-C18
A10-B2-C19 A10-B2-C20 A10-B2-C21 A10-B2-C22 A10-B2-C23 A10-B2-C24
A10-B2-C25 A10-B2-C26 A10-B2-C27 A10-B2-C28 A10-B2-C29 A10-B2-C30
A10-B2-C31 A10-B2-C32 A10-B2-C33 A10-B2-C34 A10-B2-C35 A10-B2-C36
A10-B2-C37 A10-B2-C38 A10-B2-C39 A10-B2-C40 A10-B2-C41 A10-B2-C42
A10-B2-C43 A10-B2-C44 A10-B2-C45 A10-B2-C46 A10-B2-C47 A10-B2-C48
A10-B2-C49 A10-B2-C50 A10-B2-C51 A10-B2-C52 A10-B2-C53 A10-B2-C54
A10-B2-C55 AI0-B2-C56 A10-B2-C57 A10-B2-C58 A10-B2-C59 A10-B2-C60
A10-B2-C61 A10-B2-C62 A10-B2-C63 A10-B2-C64 A10-B2-C65 A10-B2-C66
A10-B2-C67 A10-B2-C68 A10-B2-C69 A10-B2-C70 A10-B2-C71 A10-B2-C72
A10-B2-C73 A10-B2-C74 A10-B2-C75 A10-B2-C76 A10-B2-C77 A10-B2-C78
A10-B2-C79 A10-B2-C80 A10-B2-C81 A10-B2-C82 A10-B2-C83 A10-B2-C84
A10-B2-C85 A10-B2-C86 A10-B2-C87 A10-B2-C88 A10-B2-C89 A10-B2-C90
A10-B2-C91 A10-B2-C92 A10-B2-C93 A10-B2-C94 A10-B2-C95 A10-B2-C96
A10-B2-C97 A10-B2-C98 A10-B2-C99 A10-B2-C100 A10-B2-C101 A10-B2-C102
A10-B2-C103 A10-B2-C104 A10-B2-C105 A10-B2-C106 A10-B2-C107 A10-B2-C108
A10-B2-CI09 A10-B2-C110 A10-B2-C1I1 A10-B2-C112 A10-B2-C113 A10-B2-C114
A10-B2-C115 A10-B2-C116 A10-B2-C117 A10-B2-C118 A10-B2-C119 A10-B2-C120
A10-B2-C121 A10-B2-C122 A10-B2-C123 A10-B2-C124 A10-B2-C125 A10-B2-C126
A10-B2-C127 A10-B2-C128 A10-B2-C129 A10-B2-C130 A10-B2-C131 A10-B2-C132
A10-B2-C133 A10-B2-C134 A10-B2-C135 A10-B2-C136 A10-B2-C137 A10-B2-C138
A10-B2-C139 A10-B2-C140 BLANK BLANK BLANK BLANK
A10-B3-C1 A10-B3-C2 A10-B3-C3 A10-B3-C4 A10-B3-C5 A10-B3-C6
A10-B3-C7 AI0-B3-C8 A10-B3-C9 A10-B3-C10 A10-B3-CI1 A10-B3-C12
A10-B3-C13 A10-B3-C14 A10-B3-C15 A10-B3-CI6 AI0-B3-C17 A10-B3-C18
A10-B3-CI9 A10-B3-C20 AI0-B3-C21 A10-B3-C22 A10-B3-C23 A10-B3-C24
A10-B3-C25 A10-B3-C26 A10-B3-C27 A10-B3-C28 A10-B3-C29 A10-B3-C30
A10-B3-C31 A10-B3-C32 A10-B3-C33 A10-B3-C34 A10-B3-C35 A10-B3-C36
A10-B3-C37 A10-B3-C38 A10-B3-C39 A10-B3-C40 A10-B3-C41 A10-B3-C42
A10-B3-C43 A10-B3-C44 A10-B3-C45 A10-B3-C46 A10-B3-C47 A10-B3-C48
A10-B3-C49 AI0-B3-C50 AI0-B3-C51 AI0-B3-C52 A10-B3-C53 A10-B3-C54
A10-B3-C55 A10-B3-C56 A10-B3-C57 A10-B3-C58 A10-B3-C59 A10-B3-C60
A10-B3-C61 A10-B3-C62 A10-B3-C63 A10-B3-C64 A10-B3-C65 A10-B3-C66
A10-B3-C67 A10-B3-C68 A10-B3-C69 A10-B3-C70 A10-B3-C71 A10-B3-C72

A10-B3-C73 A10-B3-C74 A10-B3-C75 A10-B3-C76 A10-B3-C77 A10-B3-C78
A10-B3-C79 A1O-B3-C80 A10-B3-C81 A10-B3-C82 A10-B3-C83 A10-B3-C84
A10-B3-C85 A10-B3-C86 A10-B3-C87 A10-B3-C88 A10-B3-C89 A10-B3-C90
A10-B3-C91 A10-B3-C92 AI0-B3-C93 A10-B3-C94 A10-B3-C95 A10-B3-C96
A10-B3-C97 A10-B3-C98 A10-B3-C99 A10-B3-C100 A10-B3-CI01 A10-B3-C102
A10-B3-C103 A10-B3-CI04 A10-B3-C105 A10-B3-C106 A10-B3-C107 A10-B3-C108
A10-B3-C109 A10-B3-C110 A10-B3-C111 A10-B3-C1I2 A10-B3-C113 A10-B3-C114
A10-B3-C115 A10-B3-C116 A10-B3-C117 A10-B3-C118 A10-B3-Cn9 A10-B3-C120
AI0-B3-C121 A10-B3-C122 A10-B3-C123 A10-B3-C124 A10-B3-C125 A10-B3-C126
A10-B3-C127 A10-B3-C128 A10-B3-C129 A10-B3-C13O A10-B3-C131 A10-B3-C132
A10-B3-C133 AI0-B3-C134 AI0-B3-C135 A10-B3-C136 A10-B3-C137 A10-B3-C138
A10-B3-C139 A10-B3-C140 BLANK BLANK BLANK BLANK
A10-B4-C1 A10-B4-C2 A10-B4-C3 A10-B4-C4 A10-B4-C5 A10-B4-C6
A10-B4-C7 A10-B4-C8 A10-B4-C9 A10-B4-C10 AI0-B4-C11 A10-B4-C12
A10-B4-C13 A10-B4-C14 A10-B4-C15 A10-B4-C16 A10-B4-C17 A10-B4-C18
A10-B4-C19 A10-B4-C20 A10-B4-C21 A10-B4-C22 A10-B4-C23 A10-B4-C24
A10-B4-C25 A10-B4-C26 A10-B4-C27 A10-B4-C28 A10-B4-C29 A10-B4-C30
A10-B4-C31 A10-B4-C32 A10-B4-C33 A10-B4-C34 A10-B4-C35 A10-B4-C36
A10-B4-C37 A10-B4-C38 A10-B4-C39 A10-B4-C40 A10-B4-C41 A10-B4-C42
A10-B4-C43 A10-B4-C44 A10-B4-C45 AI0-B4-C46 A10-B4-C47 A10-B4-C48
A10-B4-C49 A10-B4-C50 A10-B4-C51 A10-B4-C52 A10-B4-C53 A10-B4-C54
A10-B4-C55 A10-B4-C56 A10-B4-C57 A10-B4-C58 A10-B4-C59 A10-B4-C60
A10-B4-C61 A10-B4-C62 A10-B4-C63 A10-B4-C64 A10-B4-C65 A10-B4-C66
A10-B4-C67 A10-B4-C68 A10-B4-C69 A10-B4-C70 A10-B4-C71 A10-B4-C72
A10-B4-C73 A10-B4-C74 A10-B4-C75 A10-B4-C76 A10-B4-C77 A10-B4-C78
A10-B4-C79 A10-B4-C80 A10-B4-C81 A10-B4-C82 A10-B4-C83 A10-B4-C84
A10-B4-C85 A10-B4-C86 A10-B4-C87 A10-B4-C88 A10-B4-C89 A10-B4-C90
A10-B4-C91 A10-B4-C92 A10-B4-C93 A10-B4-C94 A10-B4-C95 A10-B4-C96
A10-B4-C97 A10-B4-C98 A10-B4-C99 A10-B4-C100 A10-B4-C101 A10-B4-C102
A10-B4-C103 A10-B4-C104 A10-B4-C105 A10-B4-C106 A10-B4-C107 A10-B4-C108
A10-B4-C109 A10-B4-C110 A10-B4-C111 A10-B4-C112 A10-B4-C113 A10-B4-C114
A10-B4-C115 A10-B4-C116 A10-B4-C1I7 A10-B4-C118 A10-B4-C119 A10-B4-C120
A10-B4-C121 A10-B4-C122 AI0-B4-CI23 A10-B4-C124 A10-B4-C125 A10-B4-C126
A10-B4-C127 A10-B4-C128 A10-B4-C129 A10-B4-C130 A10-B4-C131 A10-B4-C132
A10-B4-C133 A10-B4-C134 A10-B4-C135 A10-B4-C136 A10-B4-C137 A10-B4-C138
A10-B4-C139 A10-B4-C140 BLANK BLANK BLANK BLANK
A10-B5-C1 A10-B5-C2 A10-B5-C3 A10-B5-C4 A10-B5-C5 A10-B5-C6

A10-B5-C7 A10-B5-C8 A10-B5-C9 A10-B5-C10 A10-B5-C11 A10-B5-CI2
A10-B5-CI3 A10-B5-C14 A10-B5-C15 A10-B5-C16 A10-B5-C17 A10-B5-C18
A10-B5-C19 A10-B5-C20 A10-B5-C21 A10-B5-C22 A10-B5-C23 A10-B5-C24
A10-B5-C25 A10-B5-C26 A10-B5-C27 A10-B5-C28 A10-B5-C29 A10-B5-C30
A10-B5-C31 A10-B5-C32 A10-B5-C33 A10-B5-C34 A10-B5-C35 A10-B5-C36
A10-B5-C37 A10-B5-C38 A10-B5-C39 A10-B5-C40 A10-B5-C41 A10-B5-C42
A10-B5-C43 A10-B5-C44 A10-B5-C45 A10-B5-C46 A10-B5-C47 A10-B5-C48
A10-B5-C49 A10-B5-C50 A10-B5-C51 A10-B5-C52 A10-B5-C53 A10-B5-C54
A10-B5-C55 A10-B5-C56 A10-B5-C57 A10-B5-C58 A10-B5-C59 A10-B5-C60
A10-B5-C6I A10-B5-C62 A10-B5-C63 A10-B5-C64 A10-B5-C65 A10-B5-C66
A10-B5-C67 AI0-B5-C68 A10-B5-C69 A10-B5-C70 A10-B5-C71 A10-B5-C72
A10-B5-C73 A10-B5-C74 A10-B5-C75 A10-B5-C76 A10-B5-C77 A10-B5-C78
A10-B5-C79 A10-B5-C80 A10-B5-C81 A10-B5-C82 A10-B5-C83 A10-B5-C84
A10-B5-C85 A10-B5-C86 A10-B5-C87 A10-B5-C88 A10-B5-C89 A10-B5-C90
A10-B5-C91 A10-B5-C92 A10-B5-C93 A10-B5-C94 A10-B5-C95 A10-B5-C96
A10-B5-C97 A10-B5-C98 A10-B5-C99 A10-B5-C100 A10-B5-C101 A10-B5-C102
A10-B5-C103 A10-B5-C104 A10-B5-C105 A10-B5-C106 A10-B5-C107 A10-B5-C108
A10-B5-CI09 A10-B5-C1I0 A10-B5-C11I A10-B5-C112 A10-B5-C113 AI0-B5-C114
A10-B5-C115 A10-B5-C116 A10-B5-C117 A10-B5-C118 A10-B5-C119 A10-B5-C120
AI0-B5-CI21 A10-B5-C122 A10-B5-C123 A10-B5-C124 A10-B5-C125 AI0-B5-C126
A10-B5-C127 A10-B5-C128 A10-B5-C129 A10-B5-C130 A10-B5-C131 A10-B5-C132
A10-B5-C133 A10-B5-C134 A10-B5-C135 A10-B5-C136 A10-B5-C137 A10-B5-C138
A10-B5-C139 A10-B5-C140 BLANK BLANK BLANK BLANK
A10-B6-C1 A10-B6-C2 A10-B6-C3 A10-B6-C4 A10-B6-C5 A10-B6-C6
A10-B6-C7 A10-B6-C8 A10-B6-C9 A10-B6-C10 A10-B6-C11 A10-B6-C 12
A10-B6-C13 A10-B6-C14 A10-B6-C15 A10-B6-C16 A10-B6-C17 A10-B6-C18
A10-B6-C19 A10-B6-C20 A10-B6-C21 A10-B6-C22 A10-B6-C23 A10-B6-C24
A10-B6-C25 A10-B6-C26 A10-B6-C27 A10-B6-C28 A10-B6-C29 A10-B6-C30
A10-B6-C31 A10-B6-C32 A10-B6-C33 A10-B6-C34 A10-B6-C35 A10-B6-C36
A10-B6-C37 A10-B6-C38 A10-B6-C39 A10-B6-C40 AI0-B6-C41 A10-B6-C42
A10-B6-C43 A10-B6-C44 A10-B6-C45 A10-B6-C46 A10-B6-C47 A10-B6-C48
A10-B6-C49 A10-B6-C50 A10-B6-C51 A10-B6-C52 A10-B6-C53 A10-B6-C54
A10-B6-C55 A10-B6-C56 A10-B6-C57 A10-B6-C58 A10-B6-C59 A10-B6-C60
A10-B6-C61 A10-B6-C62 A10-B6-C63 A10-B6-C64 A10-B6-C65 A10-B6-C66
A10-B6-C67 A10-B6-C68 A10-B6-C69 A10-B6-C70 A10-B6-C71 A10-B6-C72
A10-B6-C73 A10-B6-C74 A10-B6-C75 A10-B6-C76 A10-B6-C77 A10-B6-C78
A10-B6-C79 A10-B6-C80 A10-B6-C81 A10-B6-C82 A10-B6-C83 A10-B6-C84

A10-B6-C85 A10-B6-C86 A10-B6-C87 A10-B6-C88 A10-B6-C89 A10-B6-C90
A10-B6-C91 A10-B6-C92 A10-B6-C93 A10-B6-C94 A10-B6-C95 A10-B6-C96
A10-B6-C97 A10-B6-C98 A10-B6-C99 A10-B6-C100 A10-B6-C101 A10-B6-C102
A10-B6-C103 A10-B6-C104 A10-B6-C105 A10-B6-C106 A10-B6-C107 A10-B6-C108
A10-B6-C109 A10-B6-Cn0 A10-B6-C1I1 A10-B6-C112 A10-B6-Cn3 A10-B6-C114
A10-B6-C115 A10-B6-C116 A10-B6-Cn7 A10-B6-C118 A10-B6-C119 A10-B6-C120
A10-B6-C121 A10-B6-C122 A10-B6-C123 A10-B6-C124 A10-B6-C125 A10-B6-C126
A10-B6-C127 A10-B6-C128 A10-B6-C129 A10-B6-C130 A10-B6-C131 A10-B6-C132
A10-B6-C133 A10-B6-C134 A10-B6-C135 A10-B6-C136 A10-B6-C137 A10-B6-C138
A10-B6-C139 A10-B6-C140 BLANK BLANK BLANK BLANK
A10-B7-C1 A10-B7-C2 A10-B7-C3 A10-B7-C4 A10-B7-C5 A10-B7-C6
A10-B7-C7 A10-B7-C8 A10-B7-C9 A10-B7-C10 A10-B7-C11 A10-B7-C12
A10-B7-C13 A10-B7-C14 A10-B7-C15 A10-B7-C16 A10-B7-C17 A10-B7-C18
A10-B7-C19 A10-B7-C20 A10-B7-C21 A10-B7-C22 A10-B7-C23 A10-B7-C24
A10-B7-C25 A10-B7-C26 A10-B7-C27 A10-B7-C28 A10-B7-C29 A10-B7-C30
A10-B7-C31 A10-B7-C32 A10-B7-C33 A10-B7-C34 A10-B7-C35 A10-B7-C36
A10-B7-C37 A10-B7-C38 A10-B7-C39 A10-B7-C40 A10-B7-C41 A10-B7-C42
A10-B7-C43 AI0-B7-C44 A10-B7-C45 A10-B7-C46 A10-B7-C47 A10-B7-C48
A10-B7-C49 A10-B7-C50 A10-B7-C51 A10-B7-C52 A10-B7-C53 A10-B7-C54
A10-B7-C55 A10-B7-C56 A10-B7-C57 A10-B7-C58 A10-B7-C59 A10-B7-C60
A10-B7-C61 A10-B7-C62 A10-B7-C63 A10-B7-C64 A10-B7-C65 A10-B7-C66
A10-B7-C67 A10-B7-C68 A10-B7-C69 A10-B7-C70 A10-B7-C71 A10-B7-C72
A10-B7-C73 A10-B7-C74 A10-B7-C75 A10-B7-C76 AI0-B7-C77 A10-B7-C78
A10-B7-C79 A10-B7-C80 A10-B7-C81 A10-B7-C82 A10-B7-C83 A10-B7-C84
A10-B7-C85 A10-B7-C86 A10-B7-C87 A10-B7-C88 A10-B7-C89 A10-B7-C90
A10-B7-C91 A10-B7-C92 A10-B7-C93 A10-B7-C94 A10-B7-C95 A10-B7-C96
A10-B7-C97 A10-B7-C98 A10-B7-C99 A10-B7-C100 A10-B7-C101 A10-B7-C102
A10-B7-C103 A10-B7-C104 A10-B7-C105 A10-B7-C106 A10-B7-C107 A10-B7-C108
A10-B7-C109 A10-B7-C110 A10-B7-C111 A10-B7-C112 A10-B7-C113 A10-B7-C114
A10-B7-C115 A10-B7-Cn6 A10-B7-C117 A10-B7-C118 A10-B7-C119 A10-B7-C120
A10-B7-C121 A10-B7-C122 A10-B7-C123 A10-B7-C124 A10-B7-C125 A10-B7-C126
A10-B7-C127 A10-B7-C128 A10-B7-C129 A10-B7-C130 A10-B7-C13] A10-B7-C132
A10-B7-C133 A10-B7-C134 A10-B7-C135 A10-B7-C136 A10-B7-C137 A10-B7-C138
A10-B7-C139 A10-B7-C140 BLANK BLANK BLANK BLANK
A10-B8-C1 A10-B8-C2 A10-B8-C3 A10-B8-C4 A10-B8-C5 A10-B8-C6
A10-B8-C7 A10-B8-C8 A10-B8-C9 A10-B8-C10 A10-B8-C11 A10-B8-C12
A10-B8-C13 A10-B8-C14 A10-B8-C15 A10-B8-C16 A10-B8-C17 A10-B8-C18

A10-B8-C19 A10-B8-C20 A10-B8-C21 A10-B8-C22 A10-B8-C23 A10-B8-C24
AI0-B8-C25 A10-B8-C26 A10-B8-C27 A10-B8-C28 A10-B8-C29 A10-B8-C30
A10-B8-C31 A10-B8-C32 AI0-B8-C33 A10-B8-C34 A10-B8-C35 A10-B8-C36
A10-B8-C37 A10-B8-C3 8 A10-B8-C39 A10-B8-C40 A10-B8-C41 A10-B8-C42
A10-B8-C43 A10-B8-C44 A10-B8-C45 A10-B8-C46 A10-B8-C47 A10-B8-C48
A10-B8-C49 A10-B8-C50 A10-B8-C51 A10-B8-C52 A10-B8-C53 A10-B8-C54
A10-B8-C55 A10-B8-C56 A10-B8-C57 A10-B8-C58 A10-B8-C59 A10-B8-C60
A10-B8-C61 A10-B8-C62 A10-B8-C63 A10-B8-C64 A10-B8-C65 A10-B8-C66
A10-B8-C67 A10-B8-C68 A10-B8-C69 A10-B8-C70 A10-B8-C71 A10-B8-C72
A10-B8-C73 A10-B8-C74 A10-B8-C75 A10-B8-C76 A10-B8-C77 A10-B8-C78
A10-B8-C79 A10-B8-C80 A10-B8-C81 A10-B8-C82 AlO-BS--CSS A10-B8-C84
A10-B8-C85 A10-B8-C86 A10-B8-C87 A10-B8-C88 A10-B8-C89 A10-B8-C90
A10-B8-C91 A10-B8-C92 A10-B8-C93 A10-B8-C94 A10-B8-C95 A10-B8-C96
A10-B8-C97 A10-B8-C98 A10-B8-C99 A10-B8-C100 A10-B8-C101 A10-B8-C102
A10-B8-C103 A10-B8-C104 A10-B8-C105 A10-B8-C106 A10-B8-C107 A10-B8-C108
A10-B8-C109 A10-B8-C110 A10-B8-C111 A10-B8-C1I2 A10-B8-C113 A10-B8-Cn4
AI0-B8-C115 A10-B8-C116 A10-B8-Cn7 A10-B8-C118 A10-B8-C119 A10-B8-C120
A10-B8-C121 A10-B8-C122 A10-B8-C123 A10-B8-C124 A10-B8-C125 A10-B8-C126
AI0-B8-C127 A10-B8-C128 A10-B8-C129 A10-B8-C130 A10-B8-C131 A10-B8-C132
A10-B8-C133 A10-B8-C134 AI0-B8-C135 A10-B8-C136 A10-B8-C137 AI0-B8-C138
A10-B8-C139 A10-B8-C140 BLANK BLANK BLANK BLANK
A10-B9-C1 A10-B9-C2 A10-B9-C3 A10-B9-C4 A10-B9-C5 A10-B9-C6
A10-B9-C7 A10-B9-C8 A10-B9-C9 A10-B9-C10 A10-B9-C11 A10-B9-C12
A10-B9-C13 A10-B9-C14 A10-B9-C15 A10-B9-C16 A10-B9-C17 A10-B9-C18
A10-B9-C19 A10-B9-C20 A10-B9-C21 A10-B9-C22 A10-B9-C23 A10-B9-C24
A10-B9-C25 A10-B9-C26 A10-B9-C27 A10-B9-C28 A10-B9-C29 A10-B9-C30
A10-B9-C31 A10-B9-C32 A10-B9-C33 A10-B9-C34 A10-B9-C35 A10-B9-C36
A10-B9-C37 A10-B9-C38 A10-B9-C39 A10-B9-C40 A10-B9-C41 A10-B9-C42
A10-B9-C43 A10-B9-C44 A10-B9-C45 A10-B9-C46 A10-B9-C47 A10-B9-C48
A10-B9-C49 A10-B9-C50 A10-B9-C51 A10-B9-C52 A10-B9-C53 A10-B9-C54
A10-B9-C55 A10-B9-C56 A10-B9-C57 A10-B9-C58 A10-B9-C59 A10-B9-C60
A10-B9-C61 A10-B9-C62 A10-B9-C63 A10-B9-C64 A10-B9-C65 A10-B9-C66
A10-B9-C67 A10-B9-C68 A10-B9-C69 A10-B9-C70 A10-B9-C71 A10-B9-C72
A10-B9-C73 A10-B9-C74 A10-B9-C75 A10-B9-C76 A10-B9-C77 A10-B9-C78
A10-B9-C79 A10-B9-C80 A10-B9-C81 A10-B9-C82 A10-B9-C83 A10-B9-C84
A10-B9-C85 A10-B9-C86 A10-B9-C87 A10-B9-C88 A10-B9-C89 A10-B9-C90
A10-B9-C91 A10-B9-C92 A10-B9-C93 A10-B9-C94 A10-B9-C95 A10-B9-C96

A10-B9-C97 A10-B9-C98 A10-B9-C99 A10-B9-C100 A10-B9-C101 A10-B9-C 102
A10-B9-C103 A10-B9-C104 A10-B9-C105 A10-B9-C 106 A10-B9-C107 A10-B9-C108
A10-B9-C109 A10-B9-C110 A10-B9-C111 A10-B9-C112 A10-B9-C113 A10-B9-C114
A10-B9-C115 A10-B9-C116 A10-B9-C117 A10-B9-C118 A10-B9-C119 A10-B9-C120
A10-B9-C121 A10-B9-C122 A10-B9-C123 A10-B9-C124 A10-B9-C125 A10-B9-C126
A10-B9-C127 A10-B9-C128 A10-B9-C129 A10-B9-C130 A10-B9-C131 A10-B9-C132
A10-B9-C133 A10-B9-C134 A10-B9-C135 A10-B9-C136 A10-B9-C137 A10-B9-C138
A10-B9-C139 A10-B9-C140 BLANK BLANK BLANK BLANK
AlO-BlO-Cl A10-B10-C2 A10-B10-C3 A10-B10-C4 A10-B10-C5 A10-B10-C6
A10-B10~C7 A10-B10-C8 A10-B10-C9 AIO-BIO-CIO AlO-BlO-Cll A10-B10-C12
A10-B10-C13 A10-B10-C14 A10-B10-C15 A10-B10-C16 A10-B10-C17 A10-B10-C18
A10-B10-C19 A10-B10-C20 A10-B10-C21 A10-B10-C22 A10-B10-C23 A10-B10-C24
A10-B 10-C25 A10-B 10-C26 A10-B 10-C27 A10-B 10-C28 A10-B 10-C29 A10-B 10-C30
A10-B10-C31 A10-BI0-C32 A10-B10-C33 A10-B10-C34 A10-B10-C35 A10-B10-C36
A10-B1O-C37 A10-B10-C38 A10-B10-C39 A10-B10-C40 A10-B10-C41 A10-B10-C42
A10-B 10-C43 A10-B 10-C44 A10-B 10-C45 A10-B 10-C46 A10-B 10-C47 A10-B 10-C48
A10-B 10-C49 A10-B 10-C50 A10-B 10-C51 A10-B 10-C52 A10-B 10-C53 A10-B 10-C54
A10-B 10-C55 A10-B 10-C56 A10-B 10-C57 A10-B 10-C58 A10-B 10-C59 A10-B 10-C60
A10-B 10-C61 A10-B 10-C62 A10-B 10-C63 A10-B 10-C64 A10-B 10-C65 A10-B 10-C66
A10-B 10-C67 A10-B 10-C68 A10-B 10-C69 A10-B 10-C70 A10-B 10-C71 A10-B 10-C72
A10-B 10-C73 A10-B 10-C74 A10-B 10-C75 A10-B 10-C76 A10-B 10-C77 A10-B 10-C78
A10-B 10-C79 A10-B 10-C80 A10-B 10-C81 A10-B 10-C82 A10-B 10-C83 A10-B 10-C84
A10-B 10-C85 A10-B 10-C86 A10-B 10-C87 A10-B 10-C88 A10-B 10-C89 A10-B 10-C90
A10-B 10-C91 A10-B 10-C92 A10-B 10-C93 A10-B 10-C94 A10-B 10-C95 A10-B 10-C96
A10-B10-C97 A10-B10-C98 A10-B10-C99 AIO-BIO-CIOO AIO-BIO-CIOI A10-B10-C102
AIO-B10-C103 A10-B10-C104 A10-B10-C105 A10-B10-C106 A10-B10-C107 A10-B10-C108
A10-B10-C109 AlO-BlO-CllO AlO-BlO-Clll A10-B10-C112 A10-B10-C113 A10-B10-C114
A10-B10-C115 A10-B10-C116 A10-B10-C117 A10-B10-C118 A10-B10-C119 A10-B10-C120
A10-B10-C121 A10-B10-C122 A10-B10-C123 A10-B10-C124 A10-B10-C125 A10-B10-C126
A10-B10-C127 A10-B10-C128 AI0-B10-C129 A10-B10-C130 A10-B10-C131 A10-BI0-C132
A!0-B!0-C133 A10-B10-C134 A10-B10-C135 A10-B10-C136 A10-B10-C137 A10-B10-C138
A10-B10-C139 A10-B10-C140 BLANK BLANK BLANK BLANK
AlO-Bll-Cl A10-B11-C2 A10-B11-C3 A10-B11-C4 A10-B11-C5 A10-B11-C6
A10-B11-C7 A10-B11-C8 A10-B11-C9 AlO-Bll-ClO AlO-Bll-Cll A10-B11-C12
A10-B11-C13 A10-B11-C14 A10-B11-C15 A10-B11-C16 A10-B11-C17 A10-B11-C18
A10-B11-C19 A10-B11-C20 A10-B11-C21 A10-B11-C22 A10-B11-C23 A10-B11-C24
AlO-Bl 1-C25 AlO-Bl 1-C26 AlO-Bl 1-C27 AlO-Bl 1-C28 AlO-Bl 1-C29 AlO-Bl 1-C30

A10-B11-C31 A10-B11-C32 A10-B11-C33 A10-BI1-C34 A10-B1KC35 A10-B11-C36
A10-B11-C37 A10-B11-C38 A10-B11-C39 A10-B1I-C40 A10-B11-C4I AI0-B11-C42
A10-B11-C43 A10-B11-C44 A10-Bn-C45 A10-B11-C46 A10-B11-C47 A10-B11-C48
A10-B11-C49 A10-B11-C50 A10-B11-C51 A10-BI1-C52 A10-Bn-C53 A10-B11-C54
A10-B11-C55 A10-B11-C56 AlO-Bll-CS? A10-B11-C58 A10-Bn-C59 A10-B1I-C60
A10-B11-C61 A10-Bn-C62 A10-B11-C63 A10-B11-C64 A10-B11-C65 A10-B11-C66
A10-B11-C67 A]0-Bn-C68 AI0-B11-C69 A10-B11-C70 A10-B11-C71 A10-B1NC72
A10-B11-C73 A10-Bn-C74 A10-B11-C75 AI0-B11-C76 A10-Bn-C77 A10-B11-C78
A10-B11-C79 A10-B11-C80 A10-B11-C81 A10-B11-C82 A10-B11-C83 A10-B11-C84
A10-B11-C85 A10-BI1-C86 A10-BI1-C87 A10-B11-C88 A10-B11-C89 A10-B11-C90
A10-B11-C91 A10-B11-C92 A10-B11-C93 A10-B11-C94 A10-B11-C95 A10-B11-C96
A10-B1I-C97 A10-B11-C98 A10-B11-C99 AlO-Bll-ClOO AIO-BII-CIOI A10-B11-C102
A10-B11-C103 A10-B11-C104 A10-B11-C105 A10-B11-C106 A10-B1I-C107 AlO-BIl-ClOS
A10-B11-CI09 AlO-Bll-CllO AlO-BlI-Clll A10-B11-CI12 A10-B11-C113 A10-B1I-C114
A10-B11-C115 AI0-Bll-Cn6 A10-B11-C117 AlO-Bll-CllS A10-B11-C119 A10-B11-C120
A10-Bn-C121 A10-B11-C122 A10-B11-C123 A10-B11-C124 A10-B11-C125 A10-B11-C126
A10-B11-C127 AI0-B11-C128 A10-B11-C129 A10-B11-C130 A10-B11-C131 A10-B11-C132
A10-B11-C133 A10-B11-C134 A10-B11-C135 A)0-B11-C136 A10-B11-C137 AI0-B11-C138
A10-B1I-C139 AlO-BU-CHO BLANK BLANK BLANK BLANK
AI0-B12-C1 A10-B12-C2 A10-B12-C3 A10-B12-C4 AI0-B12-C5 A10-B12-C6
A10-B12-C7 A10-B12-C8 A10-B12-C9 A10-BI2-CI0 A10-B12-C11 A10-B12-C12
AI0-B12-C13 A10-B12-C14 A10-B12-C15 A10-B12-C16 A10-B12-C17 A10-B12-C18
A10-B12-C19 A10-B12-C20 AI0-B12-C21 A10-B12-C22 A10-B12-C23 A10-B12-C24
A10-B12-C25 A10-B12-C26 A10-B12-C27 A10-B12-C28 A10-B12-C29 A10-B12-C30
A10-B12-C31 A10-B12-C32 A10-B12-C33 A10-B12-C34 A10-B12-C35 A10-B12-C36
A10-B12-C37 A10-B12-C38 A10-B12-C39 A10-B12-C40 A10-B12-C41 A10-B12-C42
A10-B12-C43 A10-B12-C44 A10-B12-C45 A10-B12-C46 A10-B12-C47 A10-B12-C48
A10-B12-C49 A10-B12-C50 -AI0-B12-C51 A10-B12-C52 A10-B12-C53 A10-B12-C54
A10-B12-C55 A10-BI2-C56 A10-B12-C57 A10-B12-C58 A10-B12-C59 A10-B12-C60
A10-B12-C61 A10-B12-C62 A10-B12-C63 A10-B12-C64 A10-B12-C65 A10-B12-C66
A10-B12-C67 A10-B12-C68 A10-B12-C69 A10-B12-C70 A10-BI2-C71 AI0-B12-C72
A10-B12-C73 A10-B12-C74 A10-B12-C75 A10-B12-C76 A10-B12-C77 A10-B12-C78
A10-B12-C79 A10-B12-C80 A10-B12-C81 A10-B12-C82 A10-B12-C83 A10-B12-C84
A10-B12-C85 A10-B12-C86 A10-BI2-C87 A10-B12-C88 A10-B12-C89 A10-B12-C90
A10-B12-C91 A10-B12-C92 A10-B12-C93 A10-B12-C94 A10-B12-C95 A10-B12-C96
A10-B12-C97 A10-B12-C98 AI0-B12-C99 A10-BI2-C100 A10-B12-C101 A10-B12-C102
A10-BI2-C103 A10-B12-C104 A10-B12-C105 A10-B12-C106 A10-B12-C107 A10-B12-C108

A10-B12-C109 A10-B12-C1]0 A10-B12-C111 A10-B12-C112 A10-B12-C113 A10-B12-C114
A10-B12-C115 A10-B12-C116 A10-B12-C117 A10-B12-C118 A10-B12-CI19 A10-B12-C120
A10-B12-C121 A10-B12-C122 A10-B12-C123 A10-B12-C124 A10-B12-C125 A10-B12-C126
A10-B12-C127 A10-B12-C128 A10-B12-C129 A10-B12-C130 A10-B12-C131 A10-B12-C132
A10-B12-C133 A10-B12-C134 A10-B12-C135 A10-B12-C136 A10-B12-C137 A10-B12-C138
A10-B12-C139 A10-B12-C140 BLANK BLANK BLANK BLANK
A10-B13-C1 A10-B13-C2 AI0-B13-C3 A10-B13-C4 A10-B13-C5 A10-B13-C6
A10-B13-C7 A10-B13-C8 AI0-B13-C9 A10-B13-CIO A10-B13-C11 A10-B13-CI2
A10-B13-C13 A10-B13-C14 AI0-B13-C15 A10-B13-C16 A10-B13-C17 A10-B13-C18
A10-B13-C19 A10-B13-C20 A10-B13-C21 A10-B13-C22 A10-BI3-C23 A10-B13-C24
A10-B13-C25 A10-B13-C26 A10-B13-C27 A10-B13-C28 A10-B13-C29 A10-B13-C30
A10-B13-C31 A10-B13-C32 A10-B13-C33 A10-B13-C34 AI0-B13-C35 A10-B13-C36
A10-B13-C37 A10-B13-C38 A10-B13-C39 A10-B13-C40 A10-B13-C41 A10-B13-C42
A10-B13-C43 A10-B13-C44 A10-B13-C45 A10-B13-C46 A10-B13-C47 A10-B13-C48
A10-BI3-C49 AI0-B13-C50 A10-B13-C51 A10-B13-C52 A10-B13-C53 A10-B13-C54
A10-B13-C55 A10-B13-C56 A10-B13-C57 A10-B13-C58 A10-B13-C59 A10-B13-C60
A10-B13-C61 A10-B13-C62 A10-B13-C63 A10-B13-C64 A10-B13-C65 A10-B13-C66
A10-B13-C67 A10-BI3-C68 A10-B13-C69 A10-B13-C70 A10-B13-C71 A10-B13-C72
A10-B13-C73 A10-B13-C74 A10-B13-C75 A10-B13-C76 A10-B13-C77 A10-B13-C78
A10-B13-C79 A10-B13-C80 A10-B13-C81 A10-B13-C82 A10-B13-C83 A10-B13-C84
A10-B13-C85 A10-B13-C86 A10-B13-C87 A10-B13-C88 A10-B13-C89 A10-B13-C90
A10-B13-C91 A10-B13-C92 A10-B13-C93 A10-B13-C94 A10-B13-C95 A10-B13-C96
A10-B13-C97 A10-B13-C98 A10-B13-C99 A10-B13-C100 A10-B13-C101 A10-B13-C102
A10-B13-C103 A10-B13-C104 A10-B13-C105 AI0-B13-C106 A10-B13-C107 A10-B13-C108
A10-B13-C109 A10-B13-C110 A10-B13-C111 A10-B13-C112 A10-B13-Cn3 A10-B13-C114
A10-B13-C115 A10-B13-Cn6 A10-B13-C117 A10-B13-C118 A10-B13-C119 A10-B13-C120
A10-B13-C121 A10-B13-C122 A10-B13-C123 A10-B13-C124 A10-B13-C125 A10-B13-C126
A10-B13-C127 A10-B13-C128 A10-B13-C129 A10-B13-C130 A10-B13-C131 A10-B13-C132
A10-B13-C133 A10-B13-C134 A10-B13-C135 A10-B13-C136 A10-B13-C137 A10-B13-C138
A10-B13-C139 A10-B13-C140 BLANK BLANK BLANK BLANK
AI1-B1-C1 A11-Bl-C2 A11-B1-C3 A11-B1-C4 A11-B1-C5 A11-B1-C6
A11-B1-C7 A11-B1,C8 A11-B1-C9 A11-B1-C10 All-Bl-Cll A11-B1-C12
A1I-B1-C13 A11-B1-C14 A11-B1-C15 A11-B1-C16 A11-B1-C17 A1I-BI-C18
A11-B1-C19 A1I-B1-C20 A11-B1-C21 A]1-B1-C22 A11-B1-C23 A11-Bl-C24
A1I-B1-C25 A11-B1-C26 A11-Bl-C27 A11-B1-C28 A11-B1-C29 A11-B1-C30
A11-B1-C31 A11-Bl-C32 A11-Bl-C33 A11-B1-C34 A11-B1-C35 A11-B1-C36
A11-B1-C37 A11-B1-C38 A11-B1-C39 A11-B1-C40 A11-B1-C41 A11-Bl-C42

AI1-B1-C43 AI1-B1-C44 A11-B1-C45 A11-B1-C46 A11-B1-C47 A11-B1-C48
A11-B1-C49 A11-B1-C50 A1]-B1-C51 A11-B1-C52 A11-B1-C53 A11-B1-C54
A11-B1-C55 AU-B1-C56 A11-B1-C57 A11-B1-C58 A11-BI-C59 AI1-B1-C60
A11-B1-C61 A11-B1-C62 A11-B1-C63 A1NB1-C64 A11-B1-C65 A11-B1-C66
A1KB1-C67 A11-B1-C68 A11-B1-C69 A11-B1-C70 A11-B1-C71 A1}-B1-C72
A11-B1-C73 A11-B1-C74 A11-B1-C75 A11-B1-C76 A11-B1-C77 A11-B1-C78
A11-B1-C79 All-Bl-CSO A11-B1-C81 AiKBl-C82 Ail-Bl-C83 A11-B1-C84
Al 1-B1-C85 Al 1-B1-C86 Al 1-B1-C87 Al 1-B1-C88 Al 1-B1-C89 Al 1-B1-C90
A11-Bl-C91 A11-B1-C92 A11-B1-C93 A11-BI-C94 A11-B1-C95 A11-B1-C96
Al 1-B1-C97 Al I.B1-C98 Al 1-B1-C99 Al NBl-ClOO Al 1-Bl-ClOl Al 1-B1-C102
AI1-B1-CI03 A11-B1-C104 A1I-B1-C105 A11-B1-C106 A11-B1-CI07 A1I-BNC108
A11-B1-C109 All-Bl-CllO All-Bl-Clll A11-B1-C112 A11-B1-C113 A11-B1-C114
Ali-Bl-C115 All-Bl-Cn6 A11-B1-C117 A11-B1-C118 A11-B1-C119 A11-B1-C120
A11-BI-C121 A11-B1-C122 A11-B1-CI23 A11-B1-C124 An-Bl-C125 A11-B1-C126
A11-B1-C127 A11-BI-C128 A11-B1-C129 A11-B1-C130 A11-B1-C131 A11-B1-C132
A1I-B1-CI33 A11-B1-C134 A11-B1-C135 A11-B1-C136 A11-B1-C137 A11-B1-C138
A11-B1-C139 A1I-B1-C140 BLANK BLANK BLANK BLANK
A11-B2-C1 All -B2-C2 A11-B2-C3 A11-B2-C4 A11-B2-C5 A11-B2-C6
A11-B2-C7 A11-B2-C8 A11-B2-C9 A11-B2-C10 A11-B2--C11 A11-B2-C12
AI1-B2-C13 A11-B2-C14 A11-B2-C15 A11-B2-C16 A11-B2-C17 A11-B2-C18
A11-B2-C19 All -B2-C20 A11-B2-C21 All -B2-C22 A11-B2-C23 A11-B2-C24
Al 1-B2-C25 Al 1-B2-C26 Al 1-B2-C27 Al 1-B2-C28 A11-B2-C29 Al 1-B2-C30
A11-B2-C31 A11-B2-C32 A11-B2-C33 A11-B2-C34 A11-B2-C35 A11-B2-C36
Al 1-B2-C37 Al 1-B2-C38 Al 1-B2-C39 Al 1-B2-C40 Al UB2-C41 Al 1-B2-C42
A11-B2-C43 A11-B2-C44 A11-B2-C45 A11-B2-C46 A11-B2-C47 A11-B2-C48
A11-B2-C49 A11-B2-C50 A11-B2-C51 A11-B2-C52 A11-B2-C53 A11-B2-C54
A11-B2-C55 A11-B2-C56 A11 -B2-C57 A11-B2-C58 A11-B2-C59 A11-B2-C60
Al 1-B2-C6I Al 1-B2-C62 Al 1-B2-C63 Al 1-B2-C64 A11-B2-C65 Al 1-B2-C66
Al 1-B2-C67 Al 1-B2-C68 Al 1-B2-C69 Al 1-B2-C70 Al 1-B2-C71 Al 1-B2-C72
A11-B2-C73 A11-B2-C74 A11-B2-C75 A11-B2-C76 A11-B2-C77 A11-B2-C78
Al 1-B2-C79 Al 1-B2-C80 Al 1-B2-C81 Al 1-B2-C82 Al 1-B2-C83 Al 1-B2-C84
Al 1-B2-C85 Al 1-B2-C86 Al 1-B2-C87 Al 1-B2-C88 Al 1-B2-C89 Al 1-B2-C90
A11-B2-C91 All -B2-C92 A11-B2-C93 All -B2-C94 A11-B2-C95 A11-B2-C96
Al 1-B2-C97 Al 1-B2-C98 Al 1-B2-C99 Al 1-B2-C100 Al 1-B2-C101 Al 1-B2-C102
A11-B2-C103 A11-B2-C104 A11-B2-C105 A11-B2-C106 AI1-B2-C107 A11-B2-C108
A11-B2-C109 A11-B2-C110 All-B2-Cin A11-B2-C112 A11-B2-C113 A11-B2-C114
A11-B2-C115 A11-B2-C116 A11-B2-C117 A11-B2-C118 A11-B2-C119 A11-B2-C120

A11-B2-C121 A11-B2-C122 A11-B2-C123 A11-B2-C124 A11-B2-C125 A11-B2-C126
A11-B2-C127 A11-B2-C128 A11-B2-C129 AI1-B2-C130 A11-B2-C131 A11-B2-C132
A11-B2-C133 A11-B2-C134 A11-B2-C135 A11-B2-C136 A11-B2-C137 A11-B2-CI38
A11-B2-C139 AI1-B2-C140 BLANK BLANK BLANK BLANK
A11-B3-C1 A11-B3-C2 A11-B3-C3 A11-B3-C4 A11-B3-C5 A11-B3-C6
A11-B3-C7 A11-B3-C8 A1I-B3-C9 A11-B3-C10 A11-B3-C11 A11-B3-C12
A11-B3-CI3 A11-B3-C14 A11-B3-C15 A11-B3-C16 A11-B3-C17 A11-B3-C18
A11-B3-C19 A11-B3-C20 A11-B3-C21 A11-B3-C22 A11-B3-C23 A11-B3-C24
A11-B3-C25 A11-B3-C26 A11-B3-C27 A11-B3-C28 A11-B3-C29 A11-B3-C30
AI1-B3-C31 AI1-B3-C32 A11-B3-C33 A11-B3-C34 A11-B3-C35 A11-B3-C36
A11-B3-C37 A11-B3-C38 A11-B3-C39 A11-B3-C40 A11-B3-C41 A11-B3-C42
A11-B3-C43 Al]-B3-C44 A11-B3-C45 A11-B3-C46 A11-B3-C47 A11-B3-C48
A11-B3-C49 A11-B3-C50 A11-B3-C51 A11-B3-C52 A11-B3-C53 A1I-B3-C54
A11-B3-C55 A11-B3-C56 A11-B3-C57 A11-B3-C58 A11-B3-C59 A11-B3-C60
A11-B3-C61 A11-B3-C62 A11-B3-C63 A11-B3-C64 A11-B3-C65 A11-B3-C66
A11-B3-C67 A11-B3-C68 A11-B3-C69 A11-B3-C70 A11-B3-C71 A11-B3-C72
A11-B3-C73 A11-B3-C74 A11-B3-C75 A11-B3-C76 A11-B3-C77 A11-B3-C78
A11-B3-C79 A11-B3-C80 A11-B3-C81 A11-B3-C82 A11-B3-C83 A11-B3-C84
A11-B3-C85 A11-B3-C86 A11-B3-C87 A11-B3-C88 A11-B3-C89 A11-B3-C90
A11-B3-C91 A11-B3-C92 A11-B3-C93 A11-B3-C94 A11-B3-C95 A11-B3-C96
A11-B3-C97 A11-B3-C98 A11-B3-C99 A11-B3-C100 A11-B3-C101 A11-B3-C102
A1I-B3-C103 A11-B3-C104 A11-B3-C105 A11-B3-C106 A11-B3-C107 A11-B3-C108
A11-B3-C109 A11-B3-C110 A11-B3-C111 A11-B3-CI12 All-B3-Cn3 A11-B3-C114
A11-B3-C115 A11-B3-C116 A1I-B3-C117 A11-B3-C118 All-B3-Cn9 A11-B3-C120
A11-B3-C121 A11-B3-C122 A11-B3-C123 A11-B3-C124 A11-B3-C125 A11-B3-C126
A11-B3-C127 A11-B3-C128 A1I-B3-C129 A11-B3-C130 A11-B3-C131 A11-B3-C132
A11-B3-C133 A11-B3-C134 A11-B3-C135 A11-B3-C136 A11-B3-C137 A11-B3-C138
Al]-B3-C139 A11-B3-C140 BLANK BLANK BLANK BLANK
A11-B4-C1 A11-B4-C2 A11-B4-C3 Al 1-B4-C4 A11-B4-C5 A11-B4-C6
A11-B4-C7 A11-B4-C8 A11-B4-C9 A11-B4-C10 A11-B4-C11 A11-B4-C12
A11-B4-C13 A11-B4-C14 A11-B4-C15 A11-B4-C16 A11-B4-C17 A11-B4-C18
A11-B4-C19 AIUB4-C20 A11-B4-C21 A11-B4-C22 A11-B4-C23 A11-B4-C24
A11-B4-C25 A11-B4-C26 A11-B4-C27 A11-B4-C28 A11-B4-C29 A11-B4-C30
A11-B4-C31 A11-B4-C32 Al 1-B4-C33 A11-B4-C34 AI1-B4-C35 A11-B4-C36
A11-B4-C37 A11-B4-C38 A11-B4-C39 A11-B4-C40 A11-B4-C41 A11-B4-C42
A11-B4-C43 A11-B4-C44 A11-B4-C45 A11-B4-C46 A11-B4-C47 A1I-B4-C48
A11-B4-C49 A11-B4-C50 A11-B4-C5I A11-B4-C52 A11-B4-C53 A11-B4-C54

A11-B4-C55 A11-B4-C56 A11-B4-C57 A11-B4-C58 AU-B4-C59 A11-B4-C60
A11-B4-C61 A11-B4-C62 A11-B4-C63 A11-B4-C64 A11-B4-C65 Al)-B4-C66
A11-B4-C67 A11-B4-C68 A11-B4-C69 A11-B4-C70 A11-B4-C71 A11-B4-C72
A11-B4-C73 A11-B4-C74 A11-B4-C75 A11-B4-C76 A11-B4-C77 A11-B4-C78
A11-B4-C79 A11-B4-C80 A11-B4-C81 A11-B4-C82 A11-B4-C83 A11-B4-C84
A1I-B4-C85 A11-B4-C86 A11-B4-C87 A11-B4-C88 A11-B4-C89 A11-B4-C90
A11-B4-C91 A11-B4-C92 A11-B4-C93 A11-B4-C94 A11-B4-C95 A11-B4-C96
A11-B4-C97 A11-B4-C98 A11-B4-C99 A11-B4-C100 A11-B4-C101 A11-B4-C102
A11-B4-C103 A11-B4-C104 A11-B4-C105 A11-B4-C106 A11-B4-C107 A11-B4-C108
A11-B4-C109 A11-B4-C110 A11-B4-C111 A11-B4-C112 A11-B4-C113 A11-B4-C114
All-B4-Cn5 AU-B4-Cn6 A11-B4-C117 A11-B4-C118 A11-B4-C119 A11-B4-C120
A11-B4-C121 AI1-B4-C122 A11-B4-C123 A11-B4-C124 A11-B4-C125 A11-B4-C126
A11-B4-C127 A11-B4-C128 A11-B4-C129 A11-B4-C130 A11-B4-C131 A11-B4-C132
A11-B4-C133 A11-B4-C134 A11-B4-C135 A11-B4-C136 A11-B4-C137 A11-B4-C138
A11-B4-C139 A11-B4-C140 BLANK BLANK BLANK BLANK
A11-B5-C1 A11-B5-C2 A11-B5-C3 A11-B5-C4 A11-B5-C5 A11-B5-C6
A11-B5-C7 A11-B5-C8 A11-B5-C9 A11-B5-C10 A11-B5-C11 A11-B5-C12
A11-B5-C13 A11-B5-C14 All-BS-ClS A11-B5-C16 A11-B5-C17 A11-B5-C18
A11-B5-C19 A11-B5-C20 A11-B5-C21 A11-B5-C22 A11-B5-C23 A11-B5-C24
A11-B5-C25 A11-B5-C26 A11-B5-C27 AI1-B5-C28 A11-B5-C29 A11-B5-C30
A11-B5-C31 A11-B5-C32 A11-B5-C33 A11-B5-C34 A11-B5-C35 A11-B5-C36
A11-B5-C37 A11-B5-C38 A11-B5-C39 A11-B5-C40 A11-B5-C41 A11-B5-C42
A11-B5-C43 A11-B5-C44 A11-B5-C45 A1I-B5-C46 A11-B5-C47 A11-B5-C48
A11-B5-C49 A11-B5-C50 A11-B5-C51 A11-B5-C52 A11-B5-C53 A11-B5-C54
A11-B5-C55 A11-B5-C56 A11-B5-C57 A11-B5-C58 A11-B5-C59 A11-B5-C60
A11-B5-C61 A11-B5-C62 A11-B5-C63 A11-B5-C64 A11-B5-C65 Al!-B5-C66
AI1-B5-C67 AII-B5-C68 A11-B5-C69 A11-B5-C70 A11-B5-C71 A11-B5-C72
A11-B5-C73 A11-B5-C74 Al 1-B5-C75 Al 1-B5-C76 A11-B5-C77 A11-B5-C78
A11-B5-C79 A11-B5-C80 A11-B5-C81 A11-B5-C82 A11-B5-C83 A11-B5-C84
A11-B5-C85 A11-B5-C86 A11-B5-C87 A11-B5-C88 A11-B5-C89 A11-B5-C90
A11-B5-C91 A1LB5-C92 A11-B5-C93 A11-B5-C94 A11-B5-C95 A11-B5-C96
A11-B5-C97 A11-B5-C98 A11-B5-C99 A11-B5-C100 AU-BS-ClOl A11-B5-C102
A11-B5-C103 A11-B5-C104 A11-B5-C105 A11-B5-C106 A11-B5-C107 A11-B5-C108
A11-B5-C109 All-B5-CnO All-BS-ClU A11-B5-C112 A11-B5-C113 A11-B5-C114
A11-B5-C115 A11-B5-C116 A11-B5-C117 A11-B5-C118 A11-B5-C119 A11-B5-C120
A11-B5-C121 A11-B5-C122 A11-B5-C123 A11-B5-C124 A11-B5-C125 A11-B5-C126
A11-B5-C127 A11-B5-C128 A11-B5-C129 A11-B5-C130 A11-B5-C131 A11-B5-C132

A11-B5-C133 AI1-B5-C134 A11-B5-C135 A11-B5-C136 A11-B5-C137 A11-B5-C138
A11-B5-C139 A11-B5-C140 BLANK BLANK BLANK BLANK
A11-B6-C1 A11-B6-C2 A11-B6-C3 Al 1-B6-C4 A11-B6-C5 A11-B6-C6
A11-B6-C7 A11-B6-C8 A11-B6-C9 A11-B6-C10 A11-B6-C11 All-B6-Ci2
A11-B6-C13 A11-B6-C14 A11-B6-C15 A11-B6-C16 A11-B6-C17 AI1-B6-C18
A11-B6-C19 A11-B6-C20 A11-B6-C21 A11-B6-C22 A11-B6-C23 A11-B6-C24
A11-B6-C25 A11-B6-C26 A11-B6-C27 A11-B6-C28 A11-B6-C29 A11-B6-C30
A11-B6-C31 A11-B6-C32 A11-B6-C33 A11-B6-C34 A1I-B6-C35 A11-B6-C36
A11-B6-C37 A1I-B6-C38 A11-B6-C39 A11-B6-C40 A11-B6-C41 A11-B6-C42
A11-B6-C43 A11-B6-C44 A11-B6-C45 A11-B6-C46 A11-B6-C47 A11-B6-C48
A11-B6-C49 A11-B6-C50 A11-B6-C51 A11-B6-C52 A11-B6-C53 A11-B6-C54
A11-B6-C55 A11-B6-C56 AH-B6-C57 AI1-B6-C58 A11-B6-C59 A11-B6-C60
A11-B6-C61 A11-B6-C62 A11-86-063 A11-B6-C64 A11-B6-C65 A11-B6-C66
A11-B6-C67 A11-B6-C68 A11-B6-C69 A11-B6-C70 A11-B6-C71 A11-B6-C72
A11-B6-C73 A11-B6-C74 A11-B6-C75 A11-B6-C76 A11-B6-C77 A11-B6-C78
AI1-B6-C79 AI1-B6-C80 A11-B6-C8I A11-B6-C82 A11-B6-C83 Al]-B6-C84
A11-B6-C85 AI1-B6-C86 A11-B6-C87 A11-B6-C88 A11-B6-C89 A11-B6-C90
AI1-B6-C91 A11-B6-C92 A11-B6-C93 A11-B6-C94 A11-B6-C95 A11-B6-C96
A11-B6-C97 A1I-B6-C98 A11-B6-C99 A11-B6-C100 A11-B6-C101 A11-B6-C102
A11-B6-C103 A11-B6-C104 A11-B6-C105 A11-B6-C106 A11-B6-C107 A11-B6-CI08
A11-B6-C109 A11-B6-C110 A11-B6-C111 A11-B6-CI12 All-B6-Cn3 A11-B6-CI14
AI1-B6-C115 A11-B6-C116 A11-B6-C117 A11-B6-C118 A11-B6-C119 A11-B6-C120
A11-B6-C121 A11-B6-C122 A11-B6-C123 A11-B6-C124 A11-B6-C125 A11-B6-C126
A11-B6-C127 A11-B6-C128 A11-B6-C129 A11-B6-C130 A11-B6-C131 A11-B6-C132
A11-B6-C133 A11-B6-C134 A11-B6-C135 A11-B6-C136 A1I-B6-C137 A11-B6-C138
A11-B6-C139 A11-B6-C140 BLANK BLANK BLANK BLANK
A11-B7-C1 A11-B7-C2 A11-B7-C3 A11-B7-C4 A11-B7-C5 A11-B7-C6
A11-B7-C7 AI1-B7-C8 A11-B7-C9 A11-B7-C10 A1]-B7-C11 A11-B7-C12
A11-B7-C13 A11-B7-C14 A11-B7-C15 A11-B7-C16 A11-B7-C17 A11-B7-C18
A11-B7-C19 A11-B7-C20 A11-B7-C21 A11-B7-C22 A11-B7-C23 A11-B7-C24
A11-B7-C25 A1I-B7-C26 A11-B7-C27 A11-B7-C28 A11-B7-C29 A11-B7-C30
AI1-B7-C31 A]l-B7-C32 A11-B7-C33 A11-B7-C34 A11-B7-C35 A11-B7-C36
A11-B7-C37 A11-B7-C38 Al 1-B7-C39 A11-B7-C40 A11-B7-C41 A11-B7-C42
A11-B7-C43 A11-B7-C44 A11-B7-C45 Al 1-B7-C46 A11-B7-C47 A11-B7-C48
A11-B7-C49 A11-B7-C50 A11-B7-C51 A11-B7-C52 A11-B7-C53 A11-B7-C54
A11-B7-C55 A11-B7-C56 A11-B7-C57 A11-B7-C58 A11-B7-C59 A11-B7-C60
A]l-B7-C61 A11-B7-C62 A11-B7-C63 A11-B7-C64 A11-B7-C65 A11-B7-C66

A11-B7-C67 A11-B7-C68 A11-B7-C69 A11-B7-C70 A11-B7-C71 A11-B7-C72
AII-B7-C73 A11-B7-C74 AI1-B7-C75 A11-B7-C76 A11-B7-C77 A11-B7-C78
A11-B7-C79 A11-B7-C80 A11-B7-C81 A11-B7-C82 A11-B7-C83 A11-B7-C84
A11-B7-C85 A11-B7-C86 A11-B7-C87 A11-B7-C88 A11-B7-C89 All -B7-C90
Ail-B7-C91 A11-B7-C92 A11-B7-C93 A11-B7-C94 A11-B7-C95 A11-B7-C96
A11-B7-C97 A11-B7-C98 A11-B7-C99 A11-B7-C100 A11-B7-C101 A11-B7-C102
A11-B7-C103 All-B7-C104- A11-B7-C105 A11-B7-C106 A11-B7-C107 A11-B7-C108
A11-B7-C109 A11-B7-C110 A11-B7-C111 A11-B7-C112 A11-B7-C113 A11-B7-C114
AI1-B7-C115 A11-B7-C116 A11-B7-C117 A11-B7-C118 A11-B7-C119 A11-B7-C120
A11-B7-C121 A11-B7-C122 A11-B7-C123 A11-B7-C124 A11-B7-C125 A11-B7-C126
A11-B7-C127 A11-B7-C128 A11-B7-C129 A11-B7-C130 A11-B7-C131 A11-B7-C132
A11-B7-C133 A11-B7-C134 A11-B7-C135 A11-B7-C136 A11-B7-C137 A11-B7-CI38
A11-B7-C139 A11-B7-C140 BLANK BLANK BLANK BLANK
A11-B8-C1 A11-B8-C2 Al 1-B8-C3 Al 1-B8-C4 A11-B8-C5 A11-B8-C6
A11-B8-C7 A11-B8-C8 A11-B8-C9 A11-B8-C10 A11-B8-C11 A11-B8-C12
A11-B8-C13 A11-B8-C14 A11-B8-C15 A11-B8-C16 A11-B8-C17 A11-B8-C18
A11-B8-C19 A11-B8-C20 A11-B8-C21 A11-B8-C22 A11-B8-C23 A11-B8-C24
A11-B8-C25 A11-B8-C26 A11-B8-C27 A11-B8-C28 A11-B8-C29 A11-B8-C30
A11-B8-C31 A11-B8-C32 A11-B8-C33 Al!-B8-C34 A11-B8-C35 A11-B8-C36
A1I-B8-C37 A11-B8-C38 A11-B8-C39 A11-B8-C40 A11-B8-C41 A11-B8-C42
A11-B8-C43 A11-B8-C44 A11-B8-C45 A11-B8-C46 A11-B8-C47 A11-B8-C48
A11-B8-C49 A11-B8-C50 A11-B8-C51 A11-B8-C52 A11-B8-C53 A11-B8-C54
A11-B8-C55 A1UB8-C56 A11-B8-C57 A11-B8-C58 A11-B8-C59 A11-B8-C60
A11-B8-C61 A11-B8-C62 A11-B8-C63 A11-B8-C64 A11-B8-C65 A11-B8-C66
A11-B8-C67 A11-B8-C68 A11-B8-C69 A11-B8-C70 A11-B8-C71 A11-B8-C72
A11-B8-C73 A11-B8-C74 A11-B8-C75 A11-B8-C76 A11-B8-C77 A11-B8-C78
A11-B8-C79 A11-B8-C80 A11-B8-C81 A11-B8-C82 A11-B8-C83 A11-B8-C84
A11-B8-C85 A11-B8-C86 A11-B8-C87 A11-B8-C88 A1I-B8-C89 A11-B8-C90
A11-B8-C91 A11-B8-C92 A11-B8-C93 A11-B8-C94 A11-B8-C95 A11-B8-C96
AI1-B8-C97 A11-B8-C98 Al 1-B8-C99 A11-B8-C100 A11-B8-C101 A11-B8-C102
A11-B8-C103 A11-B8-C104 A11-B8-C105 A11-B8-C106 A11-B8-C107 A11-B8-C108
A11-B8-C109 A11-B8-C110 A11-B8-C111 A11-B8-C112 A11-B8-C113 A11-B8-C114
A11-B8-C115 A11-B8-C116 A11-B8-C117 A11-B8-C118 A11-B8-C119 A11-B8-C120
A11-B8-C121 A11-B8-C122 Al 1-B8-C123 A11-B8-C124 A11-B8-C125 A11-B8-C126
A11-B8-C127 A11-B8-C128 A11-B8-C129 Ail-B8-C130 A11-B8-C131 A11-B8-C132
Al!-B8-C133 A11-B8-C134 A11-B8-C135 A11-B8-C136 A11-B8-C137 A11-B8-C138
A11-B8-CI39 A11-B8-C140 BLANK BLANK BLANK BLANK

A11-B9-C1 AI1-B9-C2 Al 1-B9-C3 A11-B9-C4 A11-B9-C5 A11-B9-C6
A11-B9-C7 A11-B9-C8 A11-B9-C9 A11-B9-C10 A11-B9-C11 A11-B9-C12
A11-B9-C13 A11-B9-C14 A11-B9-C15 A11-B9-C16 A11-B9-C17 A11-B9-C18
A11-B9-C19 A11-B9-C20 A11-B9-C21 A11-B9-C22 A11-B9-C23 A11-B9-C24
A11-B9-C25 A11-B9-C26 A11-B9-C27 A11-69-028 A11-B9-C29 A11-B9-C30
A11-B9-C31 Ali-B9-C32 A11-B9-C33 A11-B9-C34 A11-B9-C35 A11-B9-C36
A11-B9-C37 A11-B9-C38 Al 1-B9-C39 A11-B9-C40 A11-B9-C41 A11-B9-C42
A11-B9-C43 A11-B9-C44 Al 1-B9-C45 A11-B9-C46 A11-B9-C47 A11-B9-C48
A11-B9-C49 A11-B9-C50 A11-B9-C5] A11-B9-C52 A11-B9-C53 A11-B9-C54
A11-B9-C55 A11-B9-C56 A11-B9-C57 A11-B9-C58 A11-B9-C59 A11-B9-C60
A11-B9-C61 A11-B9-C62 A11-B9-C63 A11-B9-C64 A11-B9-C65 A11-B9-C66
A11-B9-C67 A1I-B9-C68 A11-B9-C69 A11-B9-C70 A11-B9-C71 A11-B9-C72
A11-B9-C73 A11-B9-C74 A11-B9-C75 A11-B9-C76 A11-B9-C77 A11-B9-C78
A11-B9-C79 A11-B9-C80 A11-B9-C81 Al 1-B9-C82 A11-B9-C83 A11-B9-C84
A11-B9-C85 A11-B9-C86 A11-B9-C87 A11-B9-C88 A11-B9-C89 A11-B9-C90
A11-B9-C91 A11-B9-C92 A11-B9-C93 A11-B9-C94 A11-B9-C95 A11-B9-C96
A11-B9-C97 A11-B9-C98 A11-B9-C99 A11-B9-C100 A11-B9-C101 A11-B9-C102
A11-B9-C103 A11-B9-C104 A11-B9-C105 A11-B9-C106 A11-B9-C107 A11-B9-C108
A11-B9-C109 A11-B9-C110 A11-B9-C111 A11-B9-C112 A11-B9-C113 A11-B9-C114
A11-B9-C115 A11-B9-CI16 A11-B9-C117 A11-B9-C118 A11-B9-C119 A11-B9-C120
A11-B9-C121 A11-B9-C122 A11-B9-C123 A11-B9-C124 A11-B9-C125 A1I-B9-C126
A11-B9-C127 A11-B9-C128 A11-B9-C129 A11-B9-C130 A11-B9-C131 A11-B9-C132
A11-B9-C133 A11-B9-C134 A11-B9-C135 A11-B9-C136 A11-B9-C137 A11-B9-C138
A11-B9-C139 A11-B9-C140 BLANK BLANK. BLANK BLANK
All-BlO-Cl A11-B10-C2 A11-B10-C3 A11-B10-C4 A11-B10-C5 A11-B10-C6
A11-B10-C7 A11-B10-C8 A11-B10-C9 All-BlO-ClO All-BlO-Cll A11-B10-C12
A11-B10-C13 A11-B10-C14 A11-B10-C15 A11-B10-C16 A11-B10-C17 A11-B10-C18
A11-B10-C19 A11-B10-C20 A11-B10-C21 A11-B10-C22 A11-B10-C23 A11-B10-C24
A11-B10-C25 A11-B10-C26 A11-B10-C27 A11-B10-C28 A11-B10-C29 A11-B10-C30
A11-B10-C31 A11-B10-C32 A11-B10-C33 A11-B10-C34 A11-B10-C35 A11-B10-C36
A11-B10-C37 A11-B10-C38 A11-B10-C39 A11-B10-C40 A11-B10-C41 A11-B10-C42
A11-B10-C43 A11-B10-C44 A11-B10-C45 A11-B10-C46 A11-B10-C47 A11-B10-C48
A11-B10-C49 A11-B10-C50 A11-B10-C51 A11-B10-C52 A11-B10-C53 A11-B10-C54
A11-B10-C55 A11-B10-C56 A11-B10-C57 A11-B10-C58 A11-B10-C59 A11-B10-C60
A11-B10-C61 A11-B10-C62 A11-B10-C63 A11-B10-C64 A11-B10-C65 A11-B10-C66
A11-B10-C67 A11-B10-C68 A11-B10-C69 A11-B10-C70 A11-B10-C71 A11-B10-C72
A11-B10-C73 A11-B10-C74 A11-B10-C75 A11-B10-C76 A11-B10-C77 A11-B10-C78

A11-B10-C79 A11-B10-C80 A11-B10-C81 A11-B10-C82 A11-B10-C83 A11-B10-C84
A11-B10-C85 A11-B10-C86 A11-B10-C87 A11-B10-C88 A11-B10-C89 A11-B10-C90
AI1-B10-C91 A11-B10-C92 A11-B10-C93 A11-B10-C94 A11-B10-C95 A11-B10-C96
A1I-B10-C97 A11-B10-C98 A11-B10-C99 AIKBIO-CIOO All-BlO-ClOl A11-B10-C102
A11-B10-C103 A11-B10-C104 A11-B10-C105 Ail-B10-Cl06 A11-B10-C107 A11-B10-C108
A1I-B10-C109 All-BlO-CllO AU-BlO-Clll A11-B10-C112 A11-B10-C113 A11-B10-C114
A11-B10-C1I5 A11-B10-C116 A11-B10-C117 A11-B10-C118 A11-B10-C119 A1I-B10-C120
AI1-B10-C121 A11-B10-C122 A11-B10-C123 A11-B10-C124 A11-B10-C125 A11-B10-C126
A11-B10-C127 A11-B10-C128 A11-B10-C129 A11-B10-C130 A11-B10-C131 A11-B10-C132
A11-B10-C133 A11-B10-C134 A11-B10-C135 A11-B10-C136 A11-B10-C137 A11-B10-C138
A11-B10-C139 A11-B10-C140 BLANK BLANK BLANK BLANK
All-Bll-Cl A11-B11-C2 A11-B11-C3 A11-B1KC4 A11-B11-C5 A11-B11-C6
A11-B11-C7 All-Bil-C8 A11-B11-C9 AlI-Bll-ClO All-Bll-Cll A11-B11-C12
A11-BIl-C13 All-BU-CH A11-B11-C15 All-Bn-C16 A11-B11-C17 A11-BI1-C18
A11-Bll-C19 AU-B11-C20 A11-B11-C21 A11-B11-C22 A11-B11-C23 AII-B11-C24
A1I-B11-C25 A11-B11-C26 A11-B11-C27 A11-Bll-C28 A11-B11-C29 All-Bn-C30
A11-B1I-C31 A11-B11-C32 A11-B11-C33 All-Bn-C34 A11-B11-C35 A11-B11-C36
A11-B1NC37 A11-B11-C38 A11-B11-C39 All-Bn-C40 A11-B11-C41 A11-B11-C42
A11-Bll-C43 A11-B11.C44 A11-B11-C45 A11-B11-C46 A11-B1I-C47 A11-B11-C48
A11-B11-C49 AI1-B1I-C50 A11-B11-C51 A11-B11-C52 A11-B11-C53 A11-B11-C54
A11-BI1-C55 All-Bn-C56 A1I-B11-C57 A11-B11-C58 A11-B11-C59 A11-B}l-C60
A1I-B11-C61 A11-B11-C62 A11-B11-C63 A11-B11-C64 A11-B11-C65 A11-B11-C66
A11-B11-C67 A11-B11-C68 A11-B11-C69 A11-B11-C70 A11-B11-C71 A11-B11-C72
AI1-B11-C73 A11-B11-C74 A11-BU-C75 AII-B11-C76 AU-B11-C77 A11-B11-C78
A1I-B11-C79 A11-B11-C80 A11-B11-C81 A11-B11-C82 A11-BIl-C83 A11-B11-C84
A1I-B11-C85 A11-B11-C86 A11-B11-C87 A11-B11-C88 A11-BI1-C89 A11-BI1-C90
A11-B1I-C91 A11-B11.C92 A11-B11-C93 A11-B11-C94 A11-B11-C95 A11-B11-C96
A11-B11-C97 A11-B1KC98 A11-B11-C99 All-BlI-ClOO All-BU-ClOl A11-B11-C102
A11-B11-C103 A11-B11-C104 A11-B11-C105 A11-B11-C106 A11-B11-C107 A11-B11-C108
A1I-B11-C109 All-Bll-CllO All-Bll-Clll All-Bll-Cn2 All-Bll-Cin A11-B11-C114
A11-B11-C115 A11-BI1-C116 A11-B11-C117 A11-B11-C118 A11-BII-C119 A11-B11-C120
AlUBn-C121 A11-B11-C122 A11-B11-C123 AU-B11-C124 A11-B11-C125 A11-B11-C126
A11-B11-C127 A1I-B11-C128 A11-B11-C129 All-BU-CHO AI1-B11-C131 A11-Bll-C132
AI1-B11-C133 A11-B11-C134 A11-B11-C135 All-Bn-C136 A11-B11-C137 A11-B11-C138
A11-BIl-C139 A11-B11-CI40 BLANK BLANK BLANK BLANK
A11-B12-C1 A11-B12-C2 A11-B12-C3 A11-B12-C4 A11-B12-C5 A11-B12-C6
A11-B12-C7 A11-B12-C8 A11-B12-C9 A11-B12-C10 A11-B12-C11 A11-B12-C12

A11-B12-C13 A11-B12-C14 A11-B12-C15 A11-B12-C16 A11-B12-C17 A11-B12-C18
A11-B12-C19 A11-B12-C20 A11-B12-C2! A11-B12-C22 A11-B12-C23 A11-B12-C24
A11-B12-C25 A11-B12-C26 A11-B12-C27 A11-B12-C28 A11-B12-C29 A11-B12-C30
A11-B12-C31 A11-B12-C32 A11-B12-C33 A11-B12-C34 A11-B12-C35 A1I-BI2-C36
A11-B12-C37 A11-B12-C38 A11-B12-C39 A11-B12-C40 A11-B12-C41 A11-B12-C42
A11-B12-C43 A11-B12-C44 A11-B12-C45 A11-B12-C46 A11-B12-C47 A11-B12-C48
A11-B12-C49 A11-B12-C50 A11-B12-C51 A11-B12-C52 A11-B12-C53 A11-B12-C54
AI1-B12-C55 A11-B12-C56 A11-B12-C57 A11-B12-C58 A11-B12-C59 A11-B12-C60
A11-B12-C61 A11-B12-C62 A11-B12-C63 A11-B12-C64 A11-B12-C65 A11-B12-C66
A11-B12-C67 A11-B12-C68 A11-B12-C69 A11-B12-C70 A11-B12-C71 A11-B12-C72
A11-B12-C73 A11-B12-C74 A11-B12-C75 A11-B12-C76 A11-B12-C77 A11-B12-C78
A11-B12-C79 A11-B12-C80 A11-B12-C81 A11-B12-C82 A11-B12-C83 A11-B12-C84
A11-B12-C85 A11-B12-C86 A11-B12-C87 A11-B12-C88 A11-B12-C89 A11-B12-C90
A11-B12-C91 A11-B12-C92 A11-B12-C93 A11-B12-C94 A11-B12-C95 A11-B12-C96
A11-B12-C97 A11-B12-C98 A11-B12-C99 A11-B12-C100 A11-B12-C101 A11-B12-C102
A11-B12-C103 A11-B12-C104 A11-B12-C105 A11-B12-C106 A11-B12-C107 A11-B12-C108
A11-B12-C109 A11-B12-C110 A11-B12-C111 A11-B12-C112 A11-B12-C113 A11-B12-C114
All-B12-Cn5 A11-B12-C116 A11-B12-C117 A11-B12-C118 A11-B12-C119 A11-B12-C120
A11-B12-C121 A11-B12-C122 A11-B12-C123 A11-B12-C124 A11-B12-C125 A11-B12-C126
A11-B12-C127 A11-B12-C128 A11-B12-C129 A11-B12-C130 A11-B12-C131 A11-B12-C132
A11-B12-C133 A11-B12-C134 A11-B12-C135 A11-B12-C136 A11-B12-C137 A11-B12-C138
A11-B12-C139 A11-B12-C140 BLANK BLANK BLANK BLANK
A11-B13-C1 A11-B13-C2 A11-B13-C3 A11-B13-C4 A11-B13-C5 A11-B13-C6
A11-B13-C7 A11-B13-C8 A11-B13-C9 A11-B13-C10 A11-B13-C11 A11-B13-C12
A11-B13-C13 A11-B13-C14 A11-B13-C15 A11-B13-C16 A11-B13-C17 A11-B13-C18
A11-B13-C19 A11-B13-C20 A11-B13-C21 A11-B13-C22 A11-B13-C23 A11-B13-C24
A11-B13-C25 A11-B13-C26 A11-B13-C27 A11-B13-C28 A11-B13-C29 A11-B13-C30
A11-B13-C31 A11-B13-C32 A11-B13-C33 A11-B13-C34 A11-B13-C35 A11-B13-C36
A11-B13-C37 A11-B13-C38 A11-B13-C39 A11-B13-C40 A11-B13-C41 A11-B13-C42
A11-B13-C43 A11-B13-C44 A11-B13-C45 A11-B13-C46 A11-B13-C47 A11-B13-C48
A11-B13-C49 A11-B13-C50 A11-B13-C51 A11-B13-C52 AI1-B13-C53 A11-B13-C54
A11-B13-C55 A11-B13-C56 A11-B13-C57 A11-B13-C58 A11-B13-C59 A11-B13-C60
A11-B13-C61 A11-B13-C62 A11-B13-C63 A11-B13-C64 A11-B13-C65 A11-B13-C66
A11-B13-C67 Al1-B13-C68 A11-B13-C69 A11-B13-C70 A11-B13-C71 A11-B13-C72
Al)-B13-C73 A11-B13-C74 A11-B13-C75 A11-B13-C76 A11-B13-C77 A11-B13-C78
A11-B13-C79 A11-B13-C80 A11-B13-C81 A11-B13-C82 A11-B13-C83 A11-B13-C84
A11-B13-C85 A11-B13-C86 A11-B13-C87 A11-B13-C88 A11-B13-C89 A11-B13-C90

A11-B13-C91 A11-B13-C92 A11-B13-C93 A11-B13-C94 A1I-BI3-C95 AII-BI3-C96
A11-B13-C97 A11-B13-C98 A11-B13-C99 All-B13-C100 A11-B13-C101 A11-B13-C102
A11-BI3-C103 A11-B13-C104 A11-B13-C]05 A11-B13-C106 A11-B13-C107 A11-B13-C108
AII-B13-CI09 AII-BI3-CI10 AII-B13-C111 AII-B13-C112 A11-B13-C113 A11-B13-C114
A11-B13-C115 A11-B13-C116 A11-B13-C117 A11-B13-C118 AI1-B13-C119 A11-B13-C120
A11-B13-C12] A!l-B]3-C122 A11-B13-C123 A11-B13-C124 A11-B13-C125 A11-B13-C126
AI1-B13-C127 A11-B13-C128 A11-B13-C129 A1I-B13-C130 A1-B13-C131 A11-B13-C132
A11-B13-C133 A11-B13-C134 A11-B13-C135 A11-B13-C136 A11-B13-C137 AI1-BI3-C138
A11-B13-C139 A11-B13-C140 BLANK BLANK BLANK BLANK
A12-B1-C1 A12-B1-C2 A12-B1-C3 A12-B1-C4 A12-B1-C5 A12-B1-C6
A12-B1-C7 A12-B1-C8 A12-B1-C9 A12-BI-C10 A12-Bl-Cn A12-B1-C12
A12-B1-C13 A12-B1-C14 A12-B1-C15 A12-B1-C16 A12-B1-C17 A12-B1-C18
A12-B)-C19 A12-B1-C20 A12-B1-C21 A12-B1-C22 A12-B1-C23 A12-B1-C24
A12-BI-C25 A12-B1-C26 A12-B1-C27 A12-B1-C28 A12-B1-C29 A12-B1-C30
A12-B1-C31 A12-B1-C32 A12-B1-C33 A12-B1-C34 A12-B1-C35 A12-BI-C36
A12-B1-C37 A12-B1-C38 A12-B1-C39 A12-B1-C40 A12-B1-C41 A12-B1-C42
A12-B1-C43 A12-B1-C44 A12-B1-C45 A12-B1-C46 A12-B1-C47 A]2-B1-C48
A12-B1-C49 A12-B1-C50 A12-B1-C5I A12-B1-C52 AI2-B1-C53 A12-B1-C54
A12-B1-C55 A12-B1-C56 A12-B1-C57 A12-B1-C58 A12-B1-C59 A12-B1-C60
A12-B1-C61 A12-B1-C62 A12-B1-C63 A12-B1-C64 A12-B1-C65 A12-B1-C66
A12-B1-C67 A12-B1-C68 A12-B1-C69 A12-B1-C70 A12-B1-C71 A12-BI-C72
A12-B1-C73 A12-B1-C74 A12-B1-C75 A12-B1-C76 A12-B1-C77 A12-B1-C78
A12-B1-C79 A12-B1-C80 A12-B1-C81 A12-B1-C82 A12-B1-C83 A12-B1-C84
AI2-B1-.C85 A12-B1-C86 A12-B1-C87 A12-BI-C88 A12-B1-C89 A12-B1-C90
A12-B1-C91 A12-B1-C92 A12-B1-C93 A12-B1-C94 A12-B1-C95 A12-BI-C96
A12-B1-C97 A12-B1-C98 A12-B1-C99 A12-B1-C100 A12-B1-C101 A12-B1-C102
A12-B1-C103 A12-B1-C104 A12-B1-C105 A12-B1-C106 A12-B1-C107 A12-B1-C108
A12-B1-C109 A12-B1-C110 A12-Bl-Cin A12-BI-CII2 AI2-B1-C113 A12-B1-C114
A12-Bl-Cn5 A12-Bl-Cn6 A12-B1-C117 A12-B1-C118 A12-B1-C119 A12-B1-C120
A12-B1-CI21 A12-B1-C122 A12-B1-C123 A12-B1-C124 A12-B1-C125 A12-BI-C126
A12-B1-C127 AI2-B1-CI28 AI2-B1-C129 AI2-B1-C130 A12-B1-C131 A12-B1-CI32
A12-B1-C133 A12-B1-C134 AI2-B1-C135 A12-B1-C136 A12-B1-C137 A12-B1-C138
A12-B1-C139 A12-B1-C140 BLANK BLANK BLANK BLANK
A12-B2-CI A12-B2-C2 A12-B2-C3 A12-B2-C4 A12-B2-C5 A12-B2-C6
A12-B2-C7 A12-B2-C8 A12-B2-C9 A12-B2-C10 A12-B2-C11 A12-B2-C12
A12-B2.C 13 A12-B2-C14 A12-B2.C 15 A12-B2-C16 A12-B2-C17 A12-B2-C18
A12-B2-C19 A12-B2-C20 A12-B2-C21 A12-B2-C22 A12-B2-C23 A12-B2-C24

A12-B2-C25 A12-B2-C26 A12-B2-C27 A12-B2-C28 A12-B2-C29 A12-B2-C30
A12-B2-C31 A12-B2-C32 A12-B2-C33 A12-B2-C34 A12-B2-C35 A12-B2-C36
A12-B2-C37 A12-B2-C38 A12-B2-C39 A12-B2-C40 A12-B2-C41 A12-B2-C42
A12-B2-C43 A12-B2-C44 A12-B2-C45 A12-B2-C46 A12-B2-C47 A12-B2-C48
A12-B2-C49 A12-B2-C50 A12-B2-C51 A12-B2-C52 A12-B2-C53 A12-B2-C54
A12-B2-C55 A12-B2-C56 A12-B2-C57 A12-B2-C58 A12-B2-C59 A12-B2-C60
A12-B2-C61 A12-B2-C62 A12-B2-C63 A12-B2-C64 A12-B2-C65 A12-B2-C66
A12-B2-C67 A12-B2-C68 A12-B2-C69 A12-B2-C70 A12-B2-C71 A12-B2-C72
A12-B2-C73 A12-B2-C74 A12-B2-C75 A12-B2-C76 A12-B2-C77 A12-B2-C78
A12-B2-C79 A12-B2-C80 A12-B2-C8I A12-B2-C82 A12-B2-C83 AI2-B2-C84
- A12-B2-C85 A12-B2-C86 A12-B2-C87 A12-B2-C88 A12-B2-C89 A12-B2-C90
A12-B2-C91 A12-B2-C92 A12-B2-C93 A12-B2-C94 A12-B2-C95 A12-B2-C96
A12-B2-C97 A12-B2-C98 A12-B2-C99 A12-B2-C100 A12-B2-C101 A12-B2-C102
A12-B2-C103 A12-B2-C104 A12-B2-C105 A12-B2-C106 A12-B2-C107 A12-B2-C108
A12-B2-C109 A12-B2-C110 A12-B2-C111 A12-B2-C112 A12-B2-C113 A12-B2-C114
A12-B2-C115 A12-B2-C116 A12-B2-C117 A12-B2-C118 A12-B2-C119 A12-B2-C120
A12-B2-C121 A12-B2-C122 A12-B2-C123 A12-B2-C124 A12-B2-C125 A12-B2-C126
A12-B2-C127 A12-B2-C128 A12-B2-C129 A12-B2-C130 A12-B2-CI31 A12-B2-CI32
A12-B2-C133 A12-B2-C134 A12-B2-C135 A12-B2-C136 A12-B2-C137 A12-B2-C138
A12-B2-C139 A12-B2-C140 BLANK BLANK BLANK BLANK
A12-B3-C1 A12-B3-C2 A12-B3-C3 A12-B3-C4 A12-B3-C5 A12-B3-C6
A12-B3-C7 A12-B3-C8 A12-B3-C9 A12-B3-C10 A12-B3-C11 A12-B3-C12
A12-B3-C13 A12-B3-C14 A12-B3-C15 A12-B3-C16 A12-B3-C17 A12-B3-C18
- A12-B3-C19 A12-B3-C20 A12-B3-C21 A12-B3-C22 A12-B3-C23 A12-B3-C24
A12-B3-C25 A12-B3-C26 A12-B3-C27 A12-B3-C28 A12-B3-C29 A12-B3-C30
A12-B3-C31 A12-B3-C32 A12-B3-C33 A12-B3-C34 A12-B3-C35 A12-B3-C36
A12-B3-C37 A12-B3-C38 A12-B3-C39 A12-B3-C40 A12-B3-C41 A12-B3-C42
A12-B3-C43 A12-B3-C44 A12-B3-C45 A12-B3-C46 A12-B3-C47 A12-B3-C48
A12-B3-C49 A12-B3-C50 A12-B3-C51 A12-B3-C52 A12-B3-C53 A12-B3-C54
A12-B3-C55 A12-B3-C56 A12-B3-C57 A12-B3-C58 A12-B3-C59 A12-B3-C60
A12-B3-C61 A12-B3-C62 A12-B3-C63 A12-B3-C64 A12-B3-C65 A12-B3-C66
A12-B3-C67 A12-B3-C68 A12-B3-C69 A12-B3-C70 A12-B3-C71 A12-B3-C72
A12-B3-C73 A12-B3-C74 A12-B3-C75 A12-B3-C76 A12-B3-C77 A12-B3-C78
A12-B3-C79 A12-B3-C80 A12-B3-C81 A12-B3-C82 A12-B3-C83 A12-B3-C84
A12-B3-C85 A12-B3-C86 A12-B3-C87 A12-B3-C88 A12-B3-C89 A12-B3-C90
A12-B3-C91 A12-B3-C92 A12-B3-C93 A12-B3-C94 A12-B3-C95 A12-B3--C96
A12-B3-C97 A12-B3-C98 A12-B3-C99 A12-B3-C100 A12-B3-C101 A12-B3-C102
126

A12-B3-C103 A12-B3-C104 A12-B3-C105 A12-B3-C106 A12-B3-C107 AI2-B3-C108
A12-B3-C109 A12-B3-C110 A12-B3-C111 A12-B3-C112 A12-B3-C113 A12-B3-C114
A12-B3-C115 AI2-B3-C116 A12-B3-C117 A12-B3-C118 A12-B3-C119 A12-B3-CI20
A12-B3-C121 AI2-B3-C122 A12-B3-C123 A12-B3-C124 AI2-B3-C125 A12-B3-C126
AI2-B3-C127 A12-B3-C128 A12-B3-C129 A12-B3-C130 A12-B3-C131 A12-B3-C132
A12-B3-C133 A12-B3-C134 A12-B3-C135 AI2-B3-C136 A12-B3-C137 A12-B3-C138
A12-B3-C139 A12-B3-C140 BLANK BLANK BLANK BLANK
A12-B4-C1 A12-B4-C2 A12-B4-C3 A12-B4-C4 A12-B4-C5 A12-B4-C6
A12-B4-C7 A12-B4-C8 A12-B4-C9 A12-B4-C10 A12-B4-C11 A12-B4-C12
A12-B4-C13 A12-B4-C14 A12-B4-C15 A12-B4-C16 A12-B4-C17 A12-B4-C18
A12-B4-C19 A12-B4-C20 A12-B4-C21 A12-B4-C22 A12-B4-C23 A12-B4-C24
A12-B4-C25 A12-B4-C26 A12-B4-C27 A12-B4-C28 A12-B4-C29 A12-B4-C30
A12-B4-C31 A12-B4-C32 A12-B4-C33 A12-B4-C34 A12-B4-C35 A12-B4-C36
A12-B4-C37 A12-B4-C3 8 A12-B4-C39 A12-B4-C40 A12-B4-C41 A12-B4-C42
A12-B4-C43 A12-B4-C44 A12-B4-C45 A12-B4-C46 A12-B4-C47 A12-B4-C48
A12-B4-C49 A12-B4-C50 A12-B4-C51 A12-B4-C52 A12-B4-C53 A12-B4-C54
A12-B4-C55 A12-B4-C56 A12-B4-C57 A12-B4-C58 A12-B4-C59 A12-B4-C60
A12-B4-C61 A12-B4-C62 A12-B4-C63 A12-B4-C64 A12-B4-C65 A12-B4-C66
A12-B4-C67 A12-B4-C68 A12-B4-C69 A12-B4-C70 A12-B4-C71 A12-B4-C72
A12-B4-C73 A12-B4-C74 A12-B4-C75 A12-B4-C76 A12-B4-C77 A12-B4-C78
A12-B4-C79 A12-B4-C80 A12-B4-C81 A12-B4-C82 A12-B4-C83 A12-B4-C84
A12-B4-C85 A12-B4-C86 A12-B4-C87 A12-B4-C88 A12-B4-C89 A12-B4-C90
A12-B4-C91 A12-B4-C92 A12-B4-C93 A12-B4-C94 A12-B4-C95 A12-B4-C96
A12-B4-C97 A12-B4-C98 A12-B4-C99 A12-B4-C100 A12-B4-C101 A12-B4-C102
A12-B4-C103 A12-B4-C104 A12-B4-C105 A12-B4-C106 A12-B4-C107 A12-B4-C108
A12-B4-C109 A12-B4-C110 A12-B4-Cin A12-B4-C112 A12-B4-C113 A12-B4-C114
A12-B4-C115 A12-B4-C116 A12-B4-C117 A12-B4-C118 A12-B4-C119 A12-B4-C120
A12-B4-C121 A12-B4-C122 A12-B4-C123 A12-B4-C124 A12-B4-C 125 A12-B4-C126
A12-B4-C127 A12-B4-CI28 A12-B4-C129 A12-B4-C130 A12-B4-C131 A12-B4-C132
A12-B4-C133 A12-B4-C134 A12-B4-C135 A12-B4-C136 A12-B4-C137 A12-B4-C138
A12-B4-C139 A12-B4-C140 BLANK BLANK BLANK BLANK
A12-B5-Ci A12-B5-C2 A12-B5-C3 A12-B5-C4 A12-B5-C5 A12-B5-C6
A12-B5-C7 A12-B5-C8 A12-B5-C9 A12-B5-C10 A12-B5-C11 A12-B5-C12
A12-B5-C13 A12-B5-C14 A12-B5-C15 A12-B5-C16 A12-B5-C17 A12-B5-C18
A12-B5-C19 A12-B5-C20 A12-B5-C21 A12-B5-C22 A12-B5-C23 A12-B5-C24
A12-B5-C25 A12-B5-C26 A12-B5-C27 A12-B5-C28 A12-B5-C29 A12-B5-C30
A1I2-B5-C31 A12-B5-C32 A12-B5-C33 A12-B5-C34 A12-B5-C35 A12-B5-C36

A12-B5-C37 A12-B5-C38 A12-B5-C39 A12-B5-C40 A12-B5-C41 A12-B5-C42
A12-B5-C43 A12-B5-C44 A12-B5-C45 A12-B5-C46 A12-B5-C47 A12-B5-C48
A12-B5-C49 A12-B5-C50 A12-B5-C51 A12-B5-C52 A12-B5-C53 A12-B5-C54
A12-B5-C55 A12-B5-C56 A12-B5-C57 A12-B5-C58 A12-B5-C59 A12-B5-C60
A12-B5-C61 A12-B5-C62 A12-B5-C63 AI2-B5-C64 A12-B5-C65 A12-B5-C66
A12-B5-C67 A12-B5-C68 A12-B5-C69 A12-B5-C70 A12-B5-C71 A12-B5-C72
A12-B5-C73 A12-B5-C74 A12-B5-C75 A12-B5-C76 A12-B5-C77 A12-B5-C78
AI2-B5-C79 A12-B5-C80 A12-B5-C81 A12-B5-C82 A12-B5-C83 A12-B5-C84
A12-B5-C85 A12-B5-C86 A12-B5-C87 AI2-B5-C88 A12-B5-C89 A12-B5-C90
A12-B5-C91 A12-B5-C92 A12-B5-C93 A12-B5-C94 A12-B5-C95 A12-B5-C96
A12-B5-C97 A12-B5-C98 A12-B5-C99 A12-B5-C100 A12-B5-C101 A12-B5-C102
AI2-B5-C103 A12-B5-C104 A12-B5-C105 A12-B5-C106 A12-B5-C107 A12-B5-CI08
A12-B5-C109 A12-B5-C110 A12-B5-C111 A12-B5-C112 A12-B5-C113 A12-B5-C114
A12-B5-C115 A12-B5-C116 A12-B5-C117 A12-B5-C118 A12-B5-C119 A12-B5-C120
A12-B5-C121 A12-B5-C122 A12-B5-C123 A12-B5-C124 A12-B5-C125 A12-B5-C126
A12-B5-C127 A12-B5-C128 A12-B5-C129 A12-B5-C130 A12-B5-C131 A12-B5-C132
A12-B5-C133 A12-B5-C134 A12-B5-C135 A12-B5-C136 A12-B5-C137 A12-B5-C138
AI2-B5-C139 A12-B5-C140 BLANK BLANK BLANK BLANK
A12-B6-C1 A12-B6-C2 A12-B6-C3 A12-B6-C4 A12-B6-C5 A12-B6-C6
AI2-B6-C7 A12-B6-C8 A12-B6-C9 A12-B6-C10 A12-B6-C11 A12-B6-C12
A12-B6-C13 A12-B6-C14 A12-B6-C15 A12-B6-C16 A12-B6-CI7 A12-B6-C18
A12-B6-C19 A12-B6-C20 A12-B6-C21 A12-B6-C22 A12-B6-C23 A12-B6-C24
A12-B6-C25 A12-B6-C26 A12-B6-C27 A12-B6-C28 A12-B6-C29 A12-B6-C30
A12-B6-C3I A12-B6-C32 A12-B6-C33 A12-B6-C34 A12-B6-C35 A12-B6-C36
A12-B6-C37 A12-B6-C38 A12-B6-C39 A12-B6-C40 A12-B6-C41 A12-B6-C42
A12-B6-C43 A12-B6-C44 A12-B6-C45 A12-B6-C46 A12-B6-C47 A12-B6-C48
A12-B6-C49 A12-B6-C50 A12-B6-C51 A12-B6-C52 A12-B6-C53 AI2-B6-C54
A12-B6-C55 A12-B6-C56 A12-B6-C57 A12-B6-C58 A12-B6-C59 A12-B6-C60
A12-B6-C6] A12-B6-C62 A12-B6-C63 A12-B6-C64 A12-B6-C65 A12-B6-C66
A12-B6-C67 A12-B6-C68 A12-B6-C69 A12-B6-C70 A12-B6-C7I AI2-B6-C72
A12-B6-C73 A12-B6-C74 A12-B6-C75 A12-B6-C76 A12-B6-C77 A12-B6-C78
A12-B6-C79 A12-B6-C80 A12-B6-C81 A12-B6-C82 A12-B6-C83 A12-B6-C84
A12-B6-C85 A12-B6-C86 A12-B6-C87 A12-B6-C88 A12-B6-C89 A12-B6-C90
A12-B6-C91 A12-B6-C92 A12-B6-C93 A12-B6-C94 A12-B6-C95 A12-B6-C96
A12-B6-C97 A12-B6-C98 A12-B6-C99 A12-B6-CI00 A12-B6-C101 A12-B6-C102
A12-B6-C103 A12-B6-C104 A12-B6-C105 A12-B6-C106 A12-B6-C107 A12-B6-C108
A12-B6-C109 A12-B6-C110 A12-B6-C111 A12-B6-C112 A12-B6-C113 A12-B6-C114

A12-B6-C115 A12-B6-C116 A12-B6--C117 A12-B6-C118 A12-B6-C119 A12-B6-C120
A12-B6-C121 A12-B6-C122 A12-B6.C 123 A12-B6-C124 A12-B6-C125 A12-B6-C126
A12-B6-C127 A12-B6-C128 A12-B6-C129 A12-B6-C130 A12-B6.C131 A12-B6-C132
A12-B6-C133 A12-B6-C134 A12-B6-C135 A12-B6-C136 A12-B6~C137 A12-B6-C138
A12-B6-C139 A12-B6-C140 BLANK BLANK BLANK BLANK
A12-B7-C1 A12-B7-C2 A12-B7-C3 A12-B7-C4 A12-B7-C5 A12-B7-C6
A12-B7-C7 A12-B7-C8 A12-B7-C9 A12-B7-C10 A12-B7-C11 A12-B7-C12
A12-B7-C13 A12-B7-C14 A12-B7-C15 A12-B7-C16 A12-B7.C17 A12-B7-C18
A12-B7-C19 A12-B7-C20 A12-B7-C21 A12-B7-C22 A12-B7-C23 A12-B7-C24
A12-B7-C25 A12-B7-C26 A12-B7-C27 A12-B7-C28 A12-B7-C29 A12-B7-C30
A12-B7-C31 A12-B7-C32 A12-B7-C33 A12-B7-C34 A12-B7-C35 A12-B7-C36
A12-B7-C37 A12-B7-C38 A12-B7-C39 A12-B7-C40 A12-B7-C41 A12-B7-C42
A12-B7-C43 A12-B7-C44 A12-B7-C45 A12-B7-C46 A12-B7-C47 A12-B7-C48
A12-B7-C49 A12-B7-C50 A12-B7-C51 A12-B7-C52 A12-B7.C53 A12-B7-C54
A12-B7-C55 A12-B7-C56 A12-B7-C57 A12-B7-C58 A12-B7-C59 A12-B7-C60
A12-B7-C61 A12-B7-C62 A12-B7-C63 A12-B7-C64 A12-B7-C65 A12-B7-C66
A12-B7-C67 A12-B7-C68 A12-B7-C69 A12-B7-C70 A12-B7-C71 A12-B7-C72
A ] 2-B7-C73 A12-B7-C74 A12-B7.C75 A12-B7-C76 A12-B7-C77 A12-B7-C78
A12-B7-C79 A12-B7-C80 A12-B7-C81 A12-B7-C82 A12-B7-C83 A12-B7-C84
A12-B7-C85 A12-B7-C86 A12-B7-C87 A12-B7-C88 A12-B7-C89 A12-B7-C90
A12-B7-C91 A12-B7-C92 A12-B7-C93 A12-B7-C94 A12-B7-C95 A12-B7-C96
A12-B7-C97 A12-B7-C98 A12-B7-C99 A12-B7-C100 A12-B7-C101 A12-B7-C102
A12-B7-C103 A12-B7-C 104 A12-B7-C105 A12-B7-C106 A12-B7-C107 A12-B7-C108
A12-B7-C109 A12-B7-C110 A12-B7-C111 A12-B7-C112 A12-B7-C113 A12-B7-Cn4
A12-B7-C115 A12-B7-C116 A12-B7-C117 A12-B7-C118 A12-B7-C119 A12-B7-C120
A12-B7-C121 A12-B7-C122 A12-B7-C123 A12-B7-C124 A12-B7-C125 A12-B7-C126
A12-B7.C 127 A12-B7-C128 A12-B7-C129 A12-B7-C130 A12-B7-C131 A12-B7-C132
A12-B7-C133 A12-B7-C134 A12-B7-C135 A12-B7-C136 A12-B7-C137 A12-B7-C138
A12-B7-C139 A12-B7-C140 BLANK BLANK BLANK BLANK
A12-B8-C1 A12-B8-C2 A12-B8-C3 A12-B8-C4 A12-B8-C5 A12-B8-C6
A12-B8-C7 A12-B8-C8 A12-B8-C9 A12-B8-C10 A12-B8-C11 A12-B8-C12
A12-B8-C13 A12-B8-C14 A12-B8-C15 A12-B8-C16 A12-B8-C17 A12-B8-C18
A12-B8-C19 A12-B8-C20 A12-B8-C21 A12-B8-C22 A12-B8-C23 A12-B8-C24
A12-B8-C25 A12-B8-C26 A12-B8-C27 A12-B8-C28 A12-B8-C29 A12-B8-C30
A12-B8-C31 A12-B8-C32 A12-B8-C33 A12-B8-C34 A12-B8-C35 A12-B8-C36
A12-B8-C37 A12-B8-C38 A12-B8-C39 A12-B8-C40 A12-B8-C41 A12-B8-C42
A12-B8-C43 A12-B8-C44 A12-B8-C45 A12-B8-C46 A12-B8-C47 A12-B8-C48

A12-B8-C49 A12-B8-C50 A12-B8-C51 A12-B8-C52 A12-B8-C53 A12-B8-C54
A12-B8-C55 A12-B8-C56 A12-B8-C57 AI2-B8-C58 A12-B8-C59 A12-B8-C60
A12-B8-C61 A12-B8-C62 A12-B8-C63 A12-B8-C64 A12-B8-C65 A12-B8-C66
A12-B8-C67 A12-B8-C68 A12-B8-C69 A12-B8-C70 A12-B8-C71 A12-B8-C72
A12-B8-C73 A12-B8-C74 A12-B8-C75 A12-B8-C76 A12-B8-C77 A12-B8-C78
A12-B8-C79 A12-B8-C80 A12-B8-C8I A12-B8-C82 A12-B8-C83 A12-B8-C84
A12-B8-C85 A12-B8-C86 A12-B8-C87 A12-B8-C88 AI2-B8-C89 A12-B8-C90
A12-B8-C91 A12-B8-C92 A12-B8-C93 A12-B8-C94 A12-B8-C95 A12-B8-C96
A12-B8-C97 A12-B8-C98 A12-B8-C99 A12-B8-C100 A12-B8-C101 A12-B8-C102
A12-B8-C103 A12-B8-C104 A12-B8-C105 A12-B8-C106 A12-B8-C107 A12-B8-C108
A12-B8-C109 A12-B8-C110 A12-B8-Cm A12-B8-C112 A12-B8-C113 A12-B8-C114
A12-B8-C115 A12-B8-C116 A12-B8-C117 A12-B8-C118 A12-B8-Cn9 A12-B8-C120
A12-B8-C121 A12-B8-C122 A12-B8-C123 A12-B8-C124 A12-B8-C125 A12-B8-C126
A12-B8-C127 A12-B8-C128 A12-B8-C129 A12-B8-C130 A12-B8-C131 A12-B8-C132
A12-B8-C133 A12-B8-C134 A12-B8-C135 A12-B8-C136 A12-B8-C137 A12-B8-C138
A12-B8-C139 A12-B8-C140 BLANK BLANK BLANK BLANK
A12-B9-C1 A12-B9-C2 A12-B9-C3 A12-B9-C4 A12-B9-C5 A12-B9-C6
A12-B9-C7 A12-B9-C8 A12-B9-C9 A12-B9-C10 A12-B9-C11 A12-B9-C12
A12-B9-C13 A12-B9-C14 A12-B9-C15 A12-B9-C16 A12-B9-C17 A12-B9-C18
A12-B9-C19 AI2-B9-C20 A12-B9-C21 A12-B9-C22 A12-B9-C23 A12-B9-C24
A12-B9-C25 A12-B9-C26 A12-B9-C27 A12-B9-C28 A12-B9-C29 A12-B9-C30
A12-B9-C31 A12-B9-C32 A12-B9-C33 A12-B9-C34 A12-B9-C35 A12-B9-C36
A12-B9-C37 A12-B9-C38 A12-B9-C39 A12-B9-C40 A12-B9-C41 A12-B9-C42
A12-B9-C43 A12-B9-C44 A12-B9-C45 A12-B9-C46 A12-B9-C47 A12-B9-C48
A12-B9-C49 A12-B9-C50 A12-B9-C51 A12-B9-C52 A12-B9-C53 A12-B9-C54
A12-B9-C55 A12-B9-C56 A12-B9-C57 A12-B9-C58 A12-B9-C59 A12-B9-C60
A12-B9-C61 A12-B9-C62 A12-B9-C63 A12-B9-C64 A12-B9-C65 A12-B9-C66
A12-B9-C67 A12-B9-C68 A12-B9-C69 A12-B9-C70 A12-B9-C71 A12-B9-C72
A12-B9-C73 A12-B9-C74 A12-B9-C75 A12-B9-C76 A12-B9-C77 A12-B9-C78
A12-B9-C79 A12-B9-C80 A12-B9-C81 A12-B9-C82 A12-B9-C83 A12-B9-C84
A12-B9-C85 A12-B9-C86 A12-B9-C87 A12-B9-C88 A12-B9-C89 A12-B9-C90
A12-B9-C91 A12-B9-C92 A12-B9-C93 A12-B9-C94 A12-B9-C95 A12-B9-C96
A12-B9-C97 A12-B9-C98 A12-B9-C99 A12-B9-C100 A12-B9-C101 A12-B9-C102
A12-B9-C103 A12-B9-C104 A12-B9-C105 A12-B9-C106 A12-B9-C107 A12-B9-C108
A12-B9-C109 A12-B9-Cn0 A12-B9-Cni A12-B9-C112 A12-B9-C113 A12-B9-C114
A12-B9-C115 A12-B9-C116 A12-B9-C117 A12-B9-Cn8 A12-B9-C119 A12-B9-C120
A12-B9-C121 A12-B9-C122 A12-B9-C123 A12-B9-C124 A12-B9-C125 A12-B9-C126

A12-B9-C127 A12-B9-C128 A12-B9-C129 A12-B9-C130 A12-B9-C131 A12-B9-C132
A12-B9-C133 A12-B9-C134 A12-B9-C135 A12-B9-C136 A12-B9-C137 A12-B9-C138
A12-B9-C139 A12-B9-C140 BLANK BLANK BLANK BLANK
A12-B 10-C1 A12-B10-C2 A12-B10-C3 A12-B10-C4 A12-B10-C5 A12-B10-C6
A12-B10-C7 A12-B10-C8 A12-B10-C9 A12-B10-C10 A12-B10-C11 A12-BI0-C12
A12-B10-C13 A12-B10-C14 A12-B10-C15 A12-B10-C16 A12-B10-C17 A12-B10-C18
A12-B 10-C 19 A12-B 10-C20 A12-B 10-C21 A12-B 10-C22 A12-B 10-C23 A12-B 10-C24
A12-B 10-C25 A12-B 10-C26 A12-B 10-C27 A12-B 10-C28 A12-B 10-C29 A12-B 10-C30
A12-B10-C31 A12-B10-C32 A12-B10-C33 A12-B10-C34 A12-B10-C35 A12-B10-C36
A12-B10-C37 A12-B10-C38 A12-B10-C39 Ai2-B10-C40 A12-B10-C41 A12-B10-C42
A12-B 10-C43 A12-B 10-C44 A12-B 10-C45 A12-B 10-C46 A12-B 10-C47 A12-B 10-C48
A12-B 10-C49 A12-B 10-C50 A12-B 10-C51 A12-B 10-C52 A12-B 10-C53 A12-B 10-C54
A12-B10-C55 A12-B10-C56 A12-B10-C57 A12-B10-C58 A12-B10-C59 A12.B10-C60
A12-B 10-C61 A12-B 10-C62 A12-B 10-C63 A12-B 10-C64 A12-810-C65 A12-B 10-C66
A12-BI0-C67 A12-B10-C68 A12-B10-C69 A12-B10-C70 A12-B10-C71 A12-B10-C72
A12-B 10-C73 A12-B 10-C74 A12-B 10-C75 A12-B 10-C76 A12-B 10-C77 A12-B 10-C78
A12-B 10-C79 A12-B 10-C80 A12-B 10-C81 A12-B 10-C82 A12-B 10-C83 A12-B 10-C84
A12-B10-C85 A12-B10-C86 A12-B10-C87 A12-B10-C88 A12-B10-C89 A12-B10-C90
A12-B 10-C91 A12-B 10-C92 A12-B 10-C93 A12-B 10-C94 A12-B 10-C95 A12-B 10-C96
A12-B10-C97 A12-B10-C98 A12-B10-C99 A12-B10-C100 A12-B10-C101 A12-B10-C102
A12-B10-C103 A12-B10-C104 A12-B10-C105 A12-B10-C106 A12-B10-C107 A12-B10-C108
A12-B10-C109 A12-B10-C110 A12-B10-C111 A12-B10-C112 A12-B10-C113 A12-B10-C114
A12-B10-C115 A12-B10-C116 A12-B10-C117 A12-B10-C118 A12-B10-C119 A12-B10-C120
A12-B10-C121 A12-B10-C122 A12-B10-C123 A12-B10-C124 A12-B10-C125 A12-B10-C126
A12-B10-C127 A12-B10-C128 A12-B10-C129 A12-B10-C130 A12-B10-C131 A12-B10-C132
A12-BI0-C133 A12-B10-C134 A12-B10-C135 A12-B10-C136 A12-B10-C137 A12-B10-C138
A12-B10-C139 A12-B10-C140 BLANK BLANK BLANK BLANK
A12-B11-C1 A12-B11-C2 A12-B11-C3 A12-B11-C4 A12-B11-C5 A12-B11-C6
A12-B11-C7 A12-B11-C8 A12-B11-C9 A12-B11-C10 A12-B11-C11 A12-B11-C12
A12-B11-C13 A12-B11-C14 A12-B11-C15 A12-B11-C16 A12-B11-C17 A12-B11-C18
A12-B11-C19 A12-B11-C20 A12-B11-C21 A12-B11-C22 A12-B11-C23 A12-BII-C24
A12-B11-C25 A12-B11-C26 A12-B11-C27 A12-B11-C28 A12-B11-C29 A12-B11-C30
A12-B11-C31 A12-B11-C32 A12-B11-C33 A12-B11-C34 A12-B11-C35 AI2-B11-C36
A12-B11-C37 A12-B11-C38 A12-B11-C39 A12-B11-C40 A12-B11-C41 A12-B11-C42
A12-B 11-C43 A12-B 11-C44 A12-B 11-C45 A12-B 11-C46 A12-B 11-C47 A12-B 11-C48
A12-B11-C49 A12-B11-C50 A12-B11-C51 A12-B11-C52 A12-BI1-C53 A12-B11-C54
A12-B11-C55 A12-B11-C56 A12-B11-C57 A12-B11-C58 A12-B11-C59 Al 2-811-C60

A12-B11-C61 A12-Bn-C62 A12-B11-C63 A12-B11-C64 A12-B11-C65 A12-B11-C66
A12-B11-C67 A12-Bn-C68 A12-B11-C69 A12-Bn-C70 A12-B11-C71 A12-B11-C72
A12-B11-C73 A12-B11-C74 A12-B11-C75 A12-BU-C76 A12-B11-C77 A12-B11-C78
A12-Bn-C79 A12-B1I-C80 A12-B11-C81 A12-B1I-C82 A12-B11-C83 A12-B11-C84
A12-B11-C85 A12-Bn-C86 A12-B11-C87 A12-B11-C88 A12-B11-C89 A12-B11-C90
A12-B11-C91 A12-B11-C92 A12-B11-C93 A12-Bn-C94 A12-B11-C95 A12-B11-C96
A12-B11-C97 A12-Bn-C98 A12-B11-C99 A12-B11-C100 A12-B11-C101 A12-B11-C102
A12-B11-C103 A12-B11-C104 A12-B11-C105 A12-B11-C106 A12-B11-C107 A12-B11-C108
A12-B11-C109 A12-Bn-C110 A12-B11-C111 A12-B11-C112 A12-Bn-C113 A12-B11-C114
A12-B1I-C115 A12-B11-C116 A12-B11-C117 A12-B11-C118 A12-B1I-C119 A12-B11-C120
A12-B11-C121 A12-B11-C122 A12-B11-C123 A12-B11-C124 A12-Bn-C125 A12-B11-C126
A12-B11-C127 A12-B11-C128 A12-B11-C129 A12-B11-C130 A12-B11-C131 A12-B11-C132
A12-B11-C133 A12-B11-C134 A12-B11-C135 A12-Bn-C136 A12-B11-C137 A12-B11-C138
A12-B11-C139 A12-B11-C140 BLANK BLANK BLANK BLANK
A12-B12-C1 A12-B12-C2 A12-B12-C3 A12-B12-C4 A12-B12-C5 A12-B12-C6
A12-B12-C7 A12-B12-C8 A12-B12-C9 A12-B12-C10 A12-B12-C11 A12-B12-C12
A12-B12-C13 A12-B12-C14 A12-B12-C15 A12-B12-C16 A12-B12-C17 A12-B12-C18
A12-B12-C19 A12-B12-C20 A12-B12-C21 A12-B12-C22 A12-B12-C23 A12-BI2-C24
A12-B12-C25 A12-B12-C26 A12-B12-C27 A12-B12-C28 A12-B12-C29 A12-B12-C30
A12-B12-C31 A12-B12-C32 A12-B12-C33 A12-B12-C34 A12-B12-C35 A12-B12-C36
A12-B12-C37 A12-B12-C38 A12-B12-C39 A12-B12-C40 A12-B12-C41 A12-B12-C42
A12-B12-C43 A12-B12-C44 A12-B12-C45 A12-B12-C46 A12-B12-C47 A12-B12-C48
A12-B12-C49 A12-B12-C50 A12-B12-C51 A12-B12-C52 A12-B12-C53 A12-B12-C54
A12-B12-C55 A12-B12-C56 A12-B12-C57 A12-B12-C58 A12-B12-C59 A12-B12-C60
A12-B12-C61 A12-B12-C62 A12-B12-C63 A12-B12-C64 A12-B12-C65 A12-B12-C66
A12-B12-C67 A12-B12-C68 A12-B12-C69 A12-B12-C70 A12-B12-C71 A12-B12-C72
AI2-B12-C73 A12-B12-C74 A12-B12-C75 A12-B12-C76 A12-B12-C77 A12-B12-C78
A12-B12-C79 A12-B12-C80 A12-B12-C81 A12-B12-C82 A12-B12-C83 A12-B12-C84
A12-B12-C85 A12-B12-C86 A12-B12-C87 A12-B12-C88 A12-B12-C89 A12-B12-C90
A12-B12-C91 A12-B12-C92 A12-B12-C93 A12-B12-C94 A12-B12-C95 A12-B12-C96
A12-B12-C97 A12-B12-C98 A12-B12-C99 A12-B12-C100 A12-B12-C101 A12-B12-C102
A12-B12-C103 A12-B12-C104 A12-B12-C105 A12-B12-C106 A12-B12-C107 A12-B12-C108
A12-B12-C109 A12-B12-Cn0 A12-B12-C111 A12-B12-C112 A12-B12-C113 A12-B12-C114
A12-B12-C115 A12-B12-Cn6 A12-B12-Cn7 A12-B12-C118 A12-B12-C119 A12-B12-C120
A12-B12-C121 A12-B12-C122 A12-B12-C123 A12-B12-C124 A12-B12-C125 A12-B12-C126
A12-B12-C127 A12-B12-C128 A12-B12-C129 A12-B12-C130 A12-B12-C131 A12-B12-C132
A12-B12-C133 A12-B12-C134 A12-B12-C135 A12-B12-C136 A12-B12-C137 A12-B12-C138

A12-B12-C139 A12-B12-C140 BLANK BLANK BLANK BLANK
A12-B13-C1 A12-B13-C2 A12-B13-C3 A12-B13-C4 A12-BI3-C5 A12-B13-C6
A12-B13-C7 A12-B13-C8 A12-B13-C9 A12-B13-C10 A12-B13-C1I A12-B13-C12
A12-B13-C13 A12-B13-C14 A12-B13-C15 A12-B13-C16 A12-B13-C17 A12-B13-C18
A12-B13-C19 A12-B13-C20 A12-B13-C21 A12-B13-C22 A12-B13-C23 A12-B13-C24
A12-B13-C25 A12-BI3-C26 A12-B13-C27 A12-B13-C28 A12-B13-C29 A12-B13-C30
A12-B13-C31 A12-B13-C32 A12-B13-C33 A12-B13-C34 A12-BI3-C35 A12«B13-C36
A12-B13-C37 A12-B13-C38 A12-B13-C39 A12-B13-C40 A12-B13-C41 A12-B13-C42
A12-B13-C43 A12-B13-C44 A12-B13-C45 A12-B13-C46 A12-B13-C47 A12-B13-C48
A12-B13-C49 A12-B13-C50 A12-B13-C51 Ai2-B13-C52 A12-B13-C53 A12-B13-C54
AI2-B13-C55 A12-B13-C56 A12-B13-C57 A12-B13-C58 A12-B13-C59 A12.B13-C60
A12-B13-C61 A12-B13-C62 A12-B13-C63 A12-B13-C64 A12-B13-C65 A12-B13-C66
A12-B13-C67 A12-B13-C68 AI2-B13-C69 A12-B13-C70 A12-B13-C71 A12-B13-C72
A12-B13-C73 A12-B13-C74 A12-B13-C75 AI2-B13-C76 A12-B13-C77 A12-B13-C78
A12-B13-C79 A12.B13-C80 Ai2-B13-C81 A12-B13-C82 A12-B13-C83 A12-B13-C84
A12-B13-C85 A12-B13-C86 A12-B13-C87 A12-B13-C88 A12-B13-C89 A12-BI3-C90
A12-B13-C91 A12-B13-C92 A12-B13-C93 A12-B13-C94 A12-B13-C95 A12-B13-C96
A12-B13-C97 A12-B13-C98 A12-B13-C99 A12-B13-C100 A12-B13-C101 A12.B13-C102
A12-B13-C103 A12-B13-C104 A12-B13-C105 A12-B13-C106 A12-B13-C107 A12-B13-C108
A12-B13-C109 A12--B13-C110 A12-B13-C1I1 A12-B13-C112 A12-B13-C113 A12-B13-C114
A12-B13-C115 A12-B13-C116 A12-B13-C117 A12-B13-C118 A12-B13-C119 A12-B13-C120
A12-B13-C121 A12-BI3-C122 A12-B13-C123 A12~B13-C124 A12-B13-C125 A12-B13-C126
A12-B13-C127 A12-B13-C128 A12-B13-C129 A12-B13-C130 A12-B13-C131 A12-B13-C132
AI2-B13-C133 AI2-B13-C134 A12-BI3-C135 A12-B13-C136 A12-B13-CI37 A12-B13-C138
A12-B13-C139 A12-B13-C140 BLANK BLANK BLANK BLANK.


Preferred compounds of the invention are selected from: 3-[l-(5-phenylethynyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine; 3-[I-(3-phenylethyl-benzoyl)-piperidin-4-yl]-benzylamine; 3-{l-[3-(4-hydroxyphenyl)ethyl-benzoyl]-piperidin-4-yl}-benzylamine; 3-{l-[3-(6-amino-pyridin-3-yl)ethyl-benzoyl]-piperidin-4-yl}-benzylamine; 3-[l-(5-phenylethyl-thiophene-2-carbonyl)-piperidin-4-yl]-benzylamine; 4-fluoro-3-[l-(5-phenylethyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine; 4-methyl-3-[l-(5-phenylethyl-pyridine-3-carbonyI)-piperidin-4-yl]-benzylamine; 3-[ 1 -(indole-6-carbonyl)-piperidin-4-yl]-benzylamine;
4-(3-aminomethyl-phenyI)-l-(5-phenethyl-pyridine-3-carbonyl)-piperidine-4-carbonitrile [4-(3-aminomethylphenyl)piperidin-l-yl]-(3,4-dichlorophenyl)methanone; l-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-methylsulfanyl-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-I-yl]-l-(3-methylsulfanyl-6,7-dihydro-benzo[c]thiophen-l-yl)-methanone trifluoroacetate;
l-{ l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-ethylsulfanyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate;
l-{l-[4-(3-Aminometiiyl-phenyl)-piperidin-l-yl]-methanoyl}-3-propylsulfanyl-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate;
l-{ l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-isopropylsulfany!-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate; ]-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-benzo[b]thiophen-2-yl-methanone-trifluoroacetate;

144-(3-Aminomethyl-phenyl)-4-hydroxy-piperidin-l-yl]-l-(5-phenethyI-pyridin-3-yl)-metha-
ditrifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-]-yl]-l-(l-methyl-lH-indol-3-yl)-methanone4rifluoroac--
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-[3-(2-fIuoro-phenylethynyl)-phenyl]-methanone
trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-{3-[2-(2-fIuoro-phenyl)-ethyl]-phenyl}-methanone
trifluoroacetate;
l-[4-(3-Aminomethyl-phenyI)-piperidin-l-yl]-l-{3-[2-(6-amino-pyridin-3-yl)-ethyl]-phenyl}-
methanone tri-trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(6-chloro-thieno[3,2-ft]thiophen-2-yl)-inethanone
trifluoroacetate;
(3R,4S) and (3S, 4R)-4-(3-Aminomethyl-phenyl)-l-(5-phenethyI-pyridine-3-carbonyl)-piperidine-3-
carboxylic acid ethyl ester dihydrochloride;
3-[l-(5-Phenylethynyl-furA11-2-carbonyl)-piperidin-4-yl]-benzylamine trifluoroacetate;
4-(3-Aminomethyl-phenyt)-piperidine-l-carboxylic acid (3,4-dichloro-phenyI)-amide trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(2,3-dihydro-benzofurA11-5-yl)-methanone;
I-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(5,6-dichIoro-pyridin-3-yi)-methanone;
1 -[4-(3-Aminomethyl-phenyl)-piperidin-l -yl]-l -(3-bromo-4-fluoro-phenyl)-methanone;
(E)-1 -[4-(3-Aminomethyl-phenyl)-piperidin-l -yI]-3-(2-nitro-phenyl)-propenone;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(3-broTno-5-iodo-phenyl)-methanone;
(E)-l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-3-phenyl-propenone;
l-[4-(3-AminomethyI-phenyl)-piperidin-l-yl]-3-cyclohexyl-propA11-l-one;
and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and prodrugs.
Pharmaceutical Compositions As explained above, compounds of the present invention exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. The present invention thus provides, according to a further aspect, compounds of the invention and phannaceutical compositions containing compounds of the invention for use in therapy, wherein a pharmaceutical composition of the present invention comprising a compound of the present invention, and a pharmaceutical ly acceptable carrier thereof. As used herein, the term -pharmaceutically acceptable- preferably means approved by a regulatory agency of a government, in particular the Federal government or a state government, or listed in the U.S. Pharmacopeia or another generally recognized pharmacopeia for use in animals, and more

particularly in humans. Suitable pharmaceutical carriers are described in -Remington-s Pharmaceutical Sciences- by E.W. Martin.
A pharmaceutical composition according to the present invention can be prepared according to the customary methods, using one or more pharmaceutically acceptable adjuvants or excipients. The adjuvants comprise, inter alia, diluents, sterile aqueous media and the various non-toxic organic solvents. The compositions may be presented in the form of tablets, pills, granules, powders, aqueous solutions or suspensions, injectable solutions, elixirs or syrups, and can contain one or more agents chosen from the group comprising sweeteners, flavorings, colorings, or stabilizers in order to obtain pharmaceutically acceptable preparations. The choice of vehicle and the content of active substance in the vehicle are generally determined in accordance with the solubility and chemical properties of the active compound, the particular mode of administration and the provisions to be observed in pharmaceutical practice. For example, excipients such as lactose, sodium citrate, calcium carbonate, dicalcium phosphate and disintegrating agents such as starch, alginic acids and certain complex silicates combined with lubricants such as magnesium stearate, sodium lauryl sulfate and talc may be used for preparing tablets. To prepare a capsule, it is advantageous to use lactose and high molecular weight polyethylene glycols. When aqueous suspensions are used they can contain emulsifying agents or agents which facilitate suspension. Diluents such as sucrose, ethanol, polyethylene glycol, propylene glycol, glycerol and chloroform or mixtures thereof may also be used. Such pharmaceutically acceptable carriers can also be sterile water and oils, including those of petroleum, animal, vegetable or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil and the like. Water is a preferred carrier when the pharmaceutical composition is administered intravenously. Saline solutions and aqueous dextrose and glycerol solutions can also be employed as liquid carriers, particularly for injectable solutions. Suitable pharmaceutical excipients include mannitol, human serum albumin (HSA), starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, magnesium carbonate, magnesium stearate, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol and the like. These compositions can take the form of solutions, suspensions, tablets, pills, capsules, powders, sustained-release formulations and the like.
Naturally, a pharmaceutical composition of the present invention compositions will contain an effective diagnostic or therapeutic amount of the active compound together with a suitable amount of carrier so as to provide the form for proper administration to the patient. While intravenous injection is a very effective form of administration, other modes can be employed, such as by injection, or by oral, nasal or parenteral administration, which are discussed infra.

Methods of Treatment Compounds within the scope of the present invention possess tryptase inhibition activity according to tests described in the literature and described in vitro procedures hereinafter, and which test results are believed to correlate to pharmacological activity in humans and other mammals. Thus, in a further embodiment, the present invention provides compounds of the invention and compositions containing compounds of the invention for use in the treatment of a patient suffering from, or subject to, conditions that can be ameliorated by the administration of an inhibitor of tryptase. For example, compounds of the present invention are useful in the treatment of inflammatory diseases, for example joint inflammation, including arthritis, rheumatoid arthritis and other arthritic conditions such as rheumatoid spondylitis, gouty arthritis, traumatic arthritis, rubella arthritis, psoriatic arthritis, osteoarthritis and other chronic inflammatory joint diseases, or diseases of joint cartilage destruction, ocular conjunctivitis, vernal conjunctivitis, inflammatory bowel disease, asthma, allergic rhinitis, interstitial lung diseases, fibrosis, sceleroderma, pulmonary fibrosis, liver cirrhosis, myocardial fibrosis, neurofibromas, hypertrophic scars, various dermatological conditions, for example, atopic dermatitis and psoriasis, myocardial infarction, stroke, angina and other consequences of atherosclerotic plaque rupture, as well as periodontal disease, diabetic retinopathy, tumor growth, anaphylaxis, multiple sclerosis, peptic ulcers, and syncytial viral infections.
A special embodiment of the therapeutic methods of the present invention is the treating of asthma.
Another special embodiment of the therapeutic methods of the present invention is the treating of joint inflammation.
Another special embodiment of the therapeutic methods of the present invention is the treating of inflammatory bowel disease.
According to a further feature of the invention there is provided a method for the treatment of a human or animal patient suffering from, or subject to, conditions which can be ameliorated by the administration of an inhibitor of tryptase, for example conditions as hereinbefore described, which comprises the administration to the patient of an effective amount of compound of the invention or a composition containing a compound of the invention. -Effective amount- is meant to describe an amount of compound of the present invention effective in inhibiting tryptase and thus producing the desired therapeutic effect.
Combination Therapy As explained above, other pharmaceutically active agents can be employed in combination with the compounds of the invention depending upon the disease being treated. For example, in the treatment

of asthma, beta-adrenergic agonists such as albuterol, terbutaline, formoterol, fenoterol or prenaline can be included, as can anticholinergics such as ipratropium bromide, anti-inflammatory corticosteroids such as beclomethasone dipropionate, triamcinolone acetonide, flunisolide or dexamethasone, and anti-inflammatory agents such as sodium cromoglycate and nedocromil sodium. Thus, the present invention extends to a pharmaceutical composition comprising a compound of the present invention and a second compound selected from the group consisting of a beta andrenergic agonist, an anticholinergic, an anti-inflammatory corticosteroid, and an anti-inflammatory agent; and a pharmaceutically acceptable carrier thereof. Particular pharmaceutical carriers having applications in this pharmaceutical composition are described herein.
Furthermore, the present invention extends to a method for treating a patient suffering from asthma, comprising administering the patient a compound of the present invention, and a second compound selected from the group consisting of a beta andrenergic agonist, an anticholinergic, an anti¬inflammatory corticosteroid, and an anti-inflammatory agent. In such a combination method, a compound of the present invention can be administered prior to the administration of the second compound, a compound of the present invention can be administered after administration of the second compound, or a compound of the present invention and the second compound can be administered concurrently.
Modes of Delivery According to the invention, a compound of the present invention, or a pharmaceutical composition of the present invention, may be introduced parenterally, transmucosally, e.g., orally, nasally, pulmonarily, or rectally, or transdermally to a patient.
Oral Delivery
Contemplated for use herein are oral solid dosage forms, which are described generally in Remington-s Pharmaceutical Sciences, 18th Ed. 1990 (Mack Publishing Co. Easton PA 18042) at Chapter 89, which is herein incorporated by reference. Solid dosage forms include tablets, capsules, pills, troches or lozenges, cachets or pellets. Also, liposomal or proteinoid encapsulation may be used to formulate the present compositions (as, for example, proteinoid microspheres reported in U.S. Patent No. 4,925,673). Liposomal encapsulation may be used and the liposomes may be derivatized with various polymers (e.g., U.S. Patent No. 5,013,556). A description of possible solid dosage forms for a therapeutic is given by Marshall, K. In: Modern Pharmaceutics Edited by G.S. Banker and C.T. Rhodes Chapter 10, 1979, herein incorporated by reference. In general, the formulation will include a compound of the present invention, and inert ingredients which allow for protection against the stomach environment, and release of the biologically active material, i.e., a compound of the present invention, in the intestine.

Also specifically contemplated are oral dosage forms of a compound of the present invention. Such a compound may be chemically modified so that oral delivery is more efficacious. Generally, the chemical modification contemplated is the attachment of at least one moiety to the component molecule itself, where said moiety permits (a) inhibition of proteolysis; and (b) uptake into the blood stream from the stomach or intestine. Also desired is the increase in overall stability of the compound of the present invention, and increase in circulation time in the body. Examples of such moieties include: polyethylene glycol, copolymers of ethylene glycol and propylene glycol, carboxymethyl cellulose, dextran, polyvinyl alcohol, polyvinyl pyrrolidone and polyproline. Abuchowski and Davis, 1981, -Soluble Polymer-Enzyme Adducts- In: Enzymes as Drugs, Hocenberg and Roberts, eds,, Wiley-lnterscience, New York, NY, pp, 367-383; Newmark, et al„ 1982, J. Appl. Biochem. 4:185-189. Other polymers that could be used are poly-l,3-dioxolane and poly-l,3,6-tioxocane. Preferred for pharmaceutical usage, as indicated above, are polyethylene glycol moieties.
For a compound of the present invention, the location of release may be the stomach, the small intestine (the duodenum, the jejunum, or the ileum), or the large intestine. One skilled in the art has available formulations that will not dissolve in the stomach, yet will release the material in the duodenum or elsewhere in the intestine. Preferably, the release will avoid the deleterious effects of the stomach environment, either by protection of the compound of the present invention, or by release of the compound beyond the stomach environment, such as in the intestine.
To ensure full gastric resistance a coating impermeable to at least pH 5.0 is essential. Examples of the more common inert ingredients that are used as enteric coatings are cellulose acetate trimellitate (CAT), hydroxypropylmethylcellulose phthalate (HPMCP), HPMCP 50, HPMCP 55, polyvinyl acetate phthalate (PVAP), Eudragit L30D, Aquateric, cellulose acetate phthalate (CAP), Eudragit L, Eudragit S, and shellac. These coatings may be used as mixed films.
A coating or mixture of coatings can also be used on tablets, which are not intended for protection against the stomach. This can include sugar coatings, or coatings that make the tablet easier to swallow. Capsules may consist of a hard shell (such as gelatin) for delivery of dry therapeutic i.e. powder; for liquid forms, a soft gelatin shell may be used. The shell material of cachets could be thick starch or other edible paper. For pills, lozenges, molded tablets or tablet triturates, moist massing techniques can be used.
The therapeutic can be included in the formulation as fine multi-particulates in the form of granules or pellets of particle size about 1 mm. The formulation of the material for capsule administration could

also be as a powder, lightly compressed plugs or even as tablets. The therapeutic could be prepared by compression.
Colorants and flavoring agents may all be included. For example, the compound of the present invention may be formulated (such as by liposome or microsphere encapsulation) and then further contained within an edible product, such as a refrigerated beverage containing colorants and flavoring agents.
One may dilute or increase the volume of the therapeutic with an inert material. These diluents could include carbohydrates, especially mannitol, a-lactose, anhydrous lactose, cellulose, sucrose, modified dextrans and starch. Certain inorganic salts may be also be used as fillers including calcium triphosphate, magnesium carbonate and sodium chloride. Some commercially available diluents are Fast-Flo, Emdex, STA-Rx 1500, Emcompress and Avicell.
Disintegrants may be included in the formulation of the therapeutic into a solid dosage form. Materials used as disintegrates include, but are not limited to starch, including the commercial disintegrant based on starch, Explotab. Sodium starch glycolate, Amberlite, sodium carboxymethylcellulose, ultramylopectin, sodium alginate, gelatin, orange peel, acid carboxymethyl cellulose, natural sponge and bentonite may all be used. Another form of the disintegrants are the insoluble cationic exchange resins. Powdered gums may be used as disintegrants and as binders and these can include powdered gums such as agar, Karaya or tragacanth. Alginic acid and its sodium salt are also useful as disintegrants.
Binders may be used to hold the therapeutic agent together to form a hard tablet and include materials from natural products such as acacia, tragacanth, starch and gelatin. Others include methyl cellulose (MC), ethyl cellulose (EC) and carboxymethyl cellulose (CMC). Polyvinyl pyrrolidone (PVP) and hydroxypropylmethyl cellulose (HPMC) could both be used in alcoholic solutions to granulate the therapeutic.
An anti-frictional agent may be included in the formulation of the therapeutic to prevent sticking during the formulation process. Lubricants may be used as a layer between the therapeutic and the die wall, and these can include but are not limited to; stearic acid including its magnesium and calcium salts, polytetrafluoroethylene (PTFE)- liquid paraffin, vegetable oils and waxes. Soluble lubricants may also be used such as sodium lauryl sulfate, magnesium lauryl sulfate, polyethylene glycol of various molecular weights, Carbowax 4000 and 6000.

Glidants that might improve the flow properties of the drug during formulation and to aid rearrangement during compression might be added. The glidants may include starch, talc, pyrogenic silica and hydrated silicoaluminate.
To aid dissolution of the therapeutic into the aqueous environment a surfactant might be added as a wetting agent. Surfactants may include anionic detergents such as sodium iauryl sulfate, dioctyl sodium sulfosuccinate and dioctyl sodium sulfonate. Cationic detergents might be used and could include benzalkonium chloride or benzethomium chloride. The list of potential non-ionic detergents that could be included in the formulation as surfactants are lauromacrogol 400, polyoxyl 40 stearate, polyoxyethylene hydrogenated castor oil 10, 50 and 60, glycerol monostearate, polysorbate 40, 60, 65 and 80, sucrose fatty acid ester, methyl cellulose and carboxymethyl cellulose. These surfactants could be present in the formulation of a compound of the present invention either alone or as a mixture in different ratios.
Additives which potentially enhance uptake of a compound of the present invention are, for instance, the fatty acids oleic acid, linoleic acid and linolenic acid.
Controlled release oral formulation may be desirable. The drug could be incorporated into an inert matrix which permits release by either diffusion or leaching mechanisms, e.g., gums. Slowly degenerating matrices may also be incorporated into the formulation. Some enteric coatings also have a delayed release effect.
Another form of a controlled release of this therapeutic is by a method based on the Oros therapeutic system (Alza Corp.), i.e. the drug is enclosed in a semipermeable membrane which allows water to enter and push drug out through a single small opening due to osmotic effects.
Other coatings may be used for the formulation. These include a variety of sugars which could be applied in a coating pan. The therapeutic agent could also be given in a film coated tablet and the materials used in this instance are divided into 2 groups. The first are the nonenteric materials and include methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, methylhydroxy-ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl-methyl cellulose, sodium carboxy-methyl cellulose, providone and the polyethylene glycols. The second group consists of the enteric materials that are commonly esters of phthalic acid.
A mix of materials might be used to provide the optimum film coating. Film coating may be carried out in a pA11-coater or in a fluidized bed or by compression coating.

Pulmonary Delivery
Also contemplated herein is pulmonary delivery of a compound of the present invention, either alone, or in a pharmaceutical composition. The compound is delivered to the lungs of a mammal while inhaling and traverses across the lung epithelial lining to the blood stream. Other reports of this include Adjei et al., 1990, Pharmaceutical Research, 7:565-569; Adjei et al., 1990, International Journal of Pharmaceutics, 63:135-144 (leuprolide acetate); Braquet et al., 1989, Journal of Cardiovascular Pharmacology, I3(suppl. 5):143-146 (endothelin-1); Hubbard et al., 1989, Annals of Internal Medicine, Vol. HI, pp. 206-212 (al- antitrypsin); Smith et al., 1989, J. Clin, Invest. 84:1145-1146 (a-1-proteinase); Oswein et al., 1990, -Aerosolization of Proteins-, Proceedings of Symposium on Respiratory Drug Delivery II, Keystone, Colorado, March, (recombinant human growth hormone); Debs et a!., 1988, J. Immunol. 140:3482-3488 (interferon-y and tumor necrosis factor alpha) and Platz et al., U.S. Patent No. 5,284,656 (granulocyte colony stimulating factor). A method and composition for pulmonary delivery of drugs for systemic effect is described in U.S. Patent No. 5,451,569, issued September 19, 1995 to Wong et al.
Contemplated for use in the practice of this invention are a wide range of mechanical devices designed for pulmonary delivery of therapeutic products, including but not limited to nebulizers, metered dose inhalers, and powder inhalers, all of which are familiar to those skilled in the art.
Some specific examples of commercially available devices suitable for the practice of this invention are the Ultravent nebulizer, manufactured by Mallinckrodt, Inc., St. Louis, Missouri; the Acorn II nebulizer, manufactured by Marquest Medical Products, Englewood, Colorado; the Ventolin metered dose inhaler, manufactured by Glaxo Inc., Research Triangle Park, North Carolina; and the Spinhaler powder inhaler, manufactured by Fisons Corp., Bedford, Massachusetts, to name only a few. Ail such devices require the use of formulations suitable for the dispensing a compound of the present invention. Typically, each formulation is specific to the type of device employed and may involve the use of an appropriate propellant material, in addition to the usual diluents, adjuvants and/or carriers useful in therapy. Also, the use of liposomes, microcapsules or microspheres, inclusion complexes, or other types of carriers is contemplated. Chemically modified compounds of the present invention may also be prepared in different formulations depending on the type of chemical modification or the type of device employed.
Formulations suitable for use with a nebulizer, either jet or ultrasonic, will typically comprise a compound of the present invention dissolved in water at a concentration of about 0.1 to 25 mg of compound per mL of solution. The formulation may also include a buffer and a simple sugar (e.g,, for stabilization and regulation of osmotic pressure). The nebulizer formulation may also contain a

surfactant, to reduce or prevent surface induced aggregation of the compound caused by atomization of the solution in forming the aerosol.
Formulations for use with a metered-dose inhaler device will generally comprise a finely divided powder containing a compound of the invention suspended in a propellant with the aid of a surfactant. The propellant may be any conventional material employed for this purpose, such as a chlorofluorocarbon, a hydrochlorofluorocarbon, a hydrofluorocarbon, or a hydrocarbon, including trichlorofluoromethane, dichlorodifluoromethane, dichlorotetrafluoroethanol, and 1,1,1,2-tetrafluoroethane, or combinations thereof. Suitable surfactants include sorbitan trioleate and soya lecithin. Oleic acid may also be useful as a surfactant
Formulations for dispensing from a powder inhaler device will comprise a finely divided dry powder containing a compound of the invention, and may also include a bulking agent, such as lactose, sorbitol, sucrose, or mannitol in amounts which facilitate dispersal of the powder from the device, e,g., 50 to 90% by weight of the formulation. The compound of the present invention should most advantageously be prepared in particulate form with an average particle size of less than 10 mm (or microns), most preferably 0.5 to 5 mm, for most effective delivery to the distal lung.
Nasal Delivery
Nasal delivery of a compound of the present invention is also contemplated. Nasal delivery allows the passage of the compound to the blood stream directly after administering the therapeutic product to the nose, without the necessity for deposition of the product in the lung. Formulations for nasal delivery include those with dextran or cyclodextran.
Transdermal Delivery
Various and numerous methods are known in the art for transdermal administration of a drug, e.g., via a transdermal patch, have applications in the present invention. Transdermal patches are described in for example, U.S. Patent No. 5,407,713, issued April 18, 1995 to Rolando et al.; U.S. Patent No. 5,352,456, issued October 4, 1004 to Fallon et al.; U.S. Patent No, 5,332,213 issued August 9, 1994 to D-Angelo et al.; U.S. Patent No. 5,336,168, issued August 9, 1994 to Sibalis; U.S. Patent No. 5,290,561, issued March I, 1994 to Farhadieh et a!.; U.S. Patent No. 5,254,346, issued October 19, 1993 to Tucker et al.; U.S. Patent No. 5,164,189, issued November 17, 1992 to Berger et al.; U.S. Patent No. 5,163,899, issued November 17, 1992 to Sibalis; U.S. Patent Nos. 5,088,977 and 5,087,240, both issued February 18, 1992 to Sibalis; U.S. Patent No. 5,008,110, issued April 16, 199! to Benecke et al,; and U.S. Patent No. 4,921,475, issued May 1, 1990 to Sibalis, the disclosure of each of which is incorporated herein by reference in its entirety.

It can be readlly appreciated that a transdermal route of administration may be enhanced by use of a dermal penetration enhancer, e.g., such as enhancers described in U.S. Patent No. 5,164,189 (supra), U.S. Patent No. 5,008,110 (supra), and U.S. Patent No. 4,879,119, issued November 7, 1989 to Aruga et al, the disclosure of each of which is incorporated herein by reference in its entirety.
Topical Administration
For topical administration, gels (water or alcohol based), creams or ointments containing compounds of the invention may be used. Compounds of the invention may also be incorporated in a gel or matrix base for application in a patch, which would allow a controlled release of compound through the transdermal barrier.
Rectal Administration
Solid compositions for rectal administration include suppositories formulated in accordance with
known methods and containing at least one compound of the invention.
The percentage of active ingredient in the compositions of the invention may be varied, it being necessary that it should constitute a proportion such that a suitable dosage shall be obtained. Obviously, several unit dosage forms may be administered at about the same time. The dose employed will be determined by the physician, and depends upon the desired therapeutic effect, the route of administration and the duration of the treatment, and the condition of the patient. In the adult, the doses are generally from about 0.001 to about 50, preferably about 0.001 to about 5, mg/kg body weight per day by inhalation, from about 0.01 to about 100, preferably 0.1 to 70, more especially 0.5 to 10, mg/kg body weight per day by oral administration, and from about 0.001 to about 10, preferably 0.01 to 1, mg/kg body weight per day by intravenous administration. In each particular case, the doses will be determined in accordance with the factors distinctive to the subject to be treated, such as age, weight, general state of health and other characteristics which can influence the efficacy of the medicinal product.
Furthermore, compounds according to the invention may be administered as frequently as necessary in order to obtain the desired therapeutic effect. Some patients may respond rapidly to a higher or lower dose and may find much weaker maintenance doses adequate. For other patients, it may be necessary to have long-term treatments at the rate of 1 to 4 doses per day, in accordance with the physiological requirements of each particular patient. Generally, the active product may be administered orally 1 to 4 times per day. Of course, for some patients, it will be necessary to prescribe not more than one or two doses per day.

Naturally, a patient in whom administration of a compound of the present invention is an effective therapeutic regimen is preferably a human, but can be any animal. Thus, as can be readily appreciated by one of ordinary skill in the art, the methods and pharmaceutical compositions of the present invention are particularly suited to administration to any animal, particularly a mammal, and including, but by no means limited to, domestic animals, such as feline or canine subjects, farm animals, such as but not limited to bovine, equine, caprine, ovine, and porcine subjects, wild animals (whether in the wild or in a zoological garden), research animals, such as mice, rats, rabbits, goats, sheep, pigs, dogs, cats, etc., avian species, such as chickens, turkeys, songbirds, etc., i.e,, for veterinary medical use.
Preparation of Compounds of the Invention Compounds of the invention may be prepared by the application or adaptation of known methods, by which is meant methods used heretofore or described in the literature, for example those described by R.C.Larock in Comprehensive Organic Transformations, VCH publishers, 1989.
In the reactions described hereinafter it may be necessary to protect reactive functional groups, for example hydroxy, amino, imino, thio or carboxy groups, where these are desired in the final product, to avoid their unwanted participation in the reactions. Conventional protecting groups may be used in accordance with standard practice, for examples see T.W. Greene and P.G.M.Wuts in -Protective Groups in Organic Chemistry- John Wiley and Sons, 1991.
Compounds of formula (la) wherein R3, R4, R5- and n are as hereinbefore defined, R1 and R2 are both hydrogen and is a single bond, represented by formula (IX), may be prepared as shown in
Scheme 1


For example compounds of formula (IX) may be prepared by:-
(i) treating compounds of formula (II) wherein R- and n are as hereinbefore defined and P- is a suitable protecting group, such as benzyloxycarbonyl, with a suitable base, such as lithium hexamethyldisilazane, in an inert solvent, such as tetrahydrofuran, and at a temperature at about -78°C, followed by reaction with N-phenyltrifluoromethane-sulfonimide to give
compounds of formula (III) wherein R4, P1- and n are as hereinbefore defined and Tf is -SO2CF3;
(ii) reaction of triflates of formula (III) with an aryl boronic acid of formula (X):-


in the presence of an aqueous base such as sodium bicarbonate and a palladium catalyst such as palladium tetrakistriphenylphosphine, and at a temperature from about 80 to about 100°C,
to give compounds of formula (IV) wherein R--, R-, P- and n are as hereinbefore defined;
(iii) reduction of compounds of formula (IV) with sodium borohydride in ethanol to give compounds of formula(V) wherein R-, R-, P- and are as hereinbefore defined;
(iv) conversion of the hydroxymethyl group in compounds of formula (V) to an aminomethyl
group which is suitably protected to facilitate the further processes described hereinafter - for example reaction of compounds of formula (V) with phosphorus tribromide in pyridine followed by treatment of the resultant bromomethyl intermediate with di-tert-
butyliminodicarboxylate to give compounds of formula (VI) wherein R-, R-, P- and n are as
hereinbefore defined and p2 and P-- are each tertiary-butyloxycarbonyl (a suitable protecting
group that is stable under conditions for the subsequent removal of protecting group P-);
(v) removal of the protecting group P- in compounds of formula (VI), for example when P- is
benzyloxycarbonyl and P- and P-- are both tertiary-butyloxycarbonyl, the deprotection may conveniently be carried out by hydrogenation in the presence of a suitable metal catalyst, e.g. platinum or palladium optionally supported on an inert carrier such as carbon, preferably in a
solvent such as methanol or ethanol to give compounds of formula (VII) wherein R-, R- and
n are as hereinbefore defined and P- and P*- are as just defined;
(vi) reaction of compounds of formula (VII) with compounds of formula (XI):-


the reaction may be carried out using standard peptide coupling procedures for example coupling in the presence of 0-(7-a2aben20triazol-l-yl)-1,l,3,3-tetramethyluronium hexafluorophosphate and triethylamine (or diisopropylethylamine) in tetrahydrofuran (or
dimethylformamide0 at room temperature; and when X1- is a halogen atom the acylation reaction may be carried out with the aid of a base, such pyridine, preferably in a solvent such as tetrahydrofuran and at a temperature at about room temperature] to give compounds of
formula (VHI) wherein R--, R--, R-, n, P- and P- are as defined above;
(vii) removal of the protecting groups P- and P- in compounds of formula (VIII), for example
when p2 and P- are both tertiary-butyloxycarbonyl the reaction may conveniently be carried out in the presence of an acid such as trifluoracetic acid in an inert solvent, such as dichloromethane, or by treatment with hydrogen chloride in methanol.
Compounds of formula (la) wherein R1, R2, R3, R4-, R5- and n are as hereinbefore defined and is a single bond, represented by formula (XVI), may be prepared as shown in scheme 2.



For example compounds of formula (XVI) may be prepared by:-
(i) reaction of compounds of formula (II) wherein R4- and n are as hereinbefore defined and P- is a suitable protecting group, such as benzyloxycarbonyl, with an aryl boronate of formula (XVII):-

wherein R1 R2-, p2 and P3- are as hereinbefore defined in the presence of potassium carbonate and a palladium catalyst such as [l,r-bis-(diphenylphosphino)ferroceno]-dichIoropalIadium (Il)-dichloromethane complex in an inert solvent, such as dimethylsulfoxide, and at a
temperature at about 80°C to give compounds of formula (XII) wherein R-, R-, R-, R-, n, P-
p2 and p3 are as hereinbefore defined; alternatively compounds of formula (XII) may be prepared by reaction of compounds of formula (II) with bis(pinacolato)boron in the presence of potassium acetate, (diphenylphosphino)-ferrocene and [l,r-bis-(diphenylphosphino)ferroceno]-dichloropalladium (II), in an inert solvent, such as dioxane, and at a temperature at about 80°C followed by reaction of the intermediate boronate of formula (XIII) with compounds of formula (XVIH):-

wherein R- R-, P- and P- are as hereinbefore defined in the presence of potassium carbonate and a palladium catalyst such as [l,r-bis-(diphenylphosphino)ferroceno]-dichloropalladium (Il)-dichloromethane complex in an inert solvent, such as dimethylsulfoxide, and at a temperature at about 80°C ];

(ii) removal of the protecting group P- in compounds of formula (XII), for example when P- is
benzyloxycarbonyl and p2 and P- are both tertiary-butyloxycarbonyl, the deprotection may conveniently be carried out by hydrogenation as described hereinabove to give compounds of formula (XIV) wherein R-, R-, R4- R5- -- p2 and P- are as just defined;
(iii) reaction of compounds of formula (XIV) with compounds of formula (XI) wherein R- is as
hereinbefore defined and X- is a hydroxy group, or a halogen, preferably chlorine, atom using standard coupling conditions [for example those described hereinabove] to give
compounds of formula (XV) wherein R-, R2, R-, R-, R5, n, P- and P- are as defined above;
(vii) removal of the protecting groups P- and P-- in compounds of formula (XV), using standard coupling conditions [for example those described hereinabove].
Compounds of formula (la) wherein R1- R2-, R3-, R4-, R5- and n are as hereinbefore defined and is a single bond, represented by formula (XVI), may also be prepared using resin technology
as shown in scheme 3:-


2% divinylbenzene), with 4-hydroxy-2,3,5,6-tetrafluorobenzoic acid, according to the


(iii) treatment of resin 1 with compounds of formula (XIV) wherein R- R-, R-, R5, n, P- and P-are as defined immediately hereinbefore, in an inert solvent, such as dichloromethane, and at a temperature at about room temperature, to give compounds of formula (XV);
(iv) removal of the protecting groups in compounds of formula (XV), for example when P- and
P-- are both tertiary-butyloxycarbonyl the reaction may conveniently be carried out in the presence of an acid such as trifluoracetic acid in an inert solvent, such as dichloromethane, or by treatment with hydrogen chloride in methanol.
Compounds of formula (lb), wherein R3 and R- are as hereinbefore defined and R- is cyano attached at the 4 position of the piperidine ring, represented by formula (XX), may be prepared as shown in scheme 4:-


For example compounds of formula (XX) may be prepared by:-
(i) Reacting a benzyl bromide of formula (XXI) wherein R- is as hereinbefore defined, with sodium cyanide, in the presence of a phase transfer catalyst, such as tetrabutylammonium bromide, in a mixture of water and an inert solvent, such as dichloromethane, and at a
temperature at about room temperature to give compounds of formula (XXII) wherein R5- is as hereinbefore defined;


wherein X is halo, preferably chloro, and P1is a suitable protecting group, sucii as tertiary-butyloxycarbonyl, in the presence of sodium hydride and in an inert solvent, such as dimethylformamide, and at a temperature at about room temperature, to give compounds of
formula (XXIII) wherein R- and P- are as hereinbefore defined;
(iii) hydrogenation of compounds of formula (XXIII) in the presence of hydrochloric acid in
ethanol and under pressure to give compounds of formula (XXIV) wherein R- and P- are as hereinbefore defined;
(iv) protection of the amino group in compounds of formula (XXIV) with a suitable protecting group, for example with a benzyloxycarbonyl group, to give compounds of formula (XXV)
wherein R-, P- and P- are as hereinbefore defined;
(v) removal of the protecting group P- in compounds of formula (XXV) to give compounds of formula (XXVI) wherein R- and P- are as hereinbefore defined;
(vi) reaction of compounds of formula (XXVI) with compounds of formula (XI) wherein R- is as
hereinbefore defined and x1- is a hydroxy group, or a halogen, preferably chlorine, atom using standard coupling conditions [for example those described hereinabove] to give
compounds of formula (XXVII) wherein R- and P-- are as defined above;
(vii) removal of the protecting groups P- in compounds of formula (XXVII), using standard coupling conditions [for example those described hereinabove].

Compounds of formula (la) wherein R-, R-, R5 and n are as hereinbefore defined, R- and R- are both hydrogen and is a double bond, represented by formula (IX), may be prepared by removal of
the P- protecting group in compounds of formula (VI) followed by acylation with compounds of formula (XI) and subsequent removal of the P- and P- protecting groups.
Compounds of formula (la) wherein R- R-, R-, R-, R- and n are as hereinbefore defined and
is a double bond, represented by formula (XVI), may be prepared by removal of the pl
protecting group in compounds of formula (XII) followed by acylation with compounds of formula (XI) and subsequent removal of the P- and P- protecting groups.
According to a further feature of the present invention, compounds of the invention may be prepared by interconversion of other compounds of the invention.
As an example of the interconversion process, compounds of formula (la) wherein R-, R-, R-, R- and
n are as hereinbefore defined and R- contains an optionally substituted alkylene linkage, may be
prepared by hydrogenation of the corresponding compounds of formula (la) in which R- contains the corresponding optionally substituted alkenylene or alkynylene linkage. The hydrogenation may be carried out using hydrogen (optionally under pressure) in the presence of a suitable metal catalyst, e.g. platinum or palladium optionally supported on an inert carrier such as carbon, preferably in a solvent such as methanol or ethanol, and at a temperature at about room temperature.
As another example of the interconversion process, compounds of the invention containing a heterocyclic group wherein the heteroatom is a nitrogen atom may be oxidized to their corresponding N-oxides. The oxidation may conveniently be carried out by means of reaction with a mixture of hydrogen peroxide and an organic acid, e.g. acetic acid, preferably at or above room temperature, for example at a temperature of about 60-90°C. Alternatively, the oxidation may be carried out by reaction with a peracid, for example peracetic acid or m-chloroperoxybenzoic acid, in an inert solvent such as chloroform or dichloromethane, at a temperature from about room temperature to reflux, preferably at elevated temperature. The oxidation may alternatively be carried out by reaction with hydrogen peroxide in the presence of sodium tungstate at temperatures between room temperature and about 60°C.
As another example of the interconversion process, compounds of formula (la) containing sulfone linkages may be prepared by the oxidation of corresponding compounds containing -S- or sulfoxide linkages. For example, the oxidation may conveniently be carried out by means of reaction with a

peroxyacid, e.g. 3-chloroperbenzoic acid, preferably in an inert solvent, e.g. dichloromethane, preferably at or near room temperature.
It will be appreciated that compounds of the present invention may contain asymmetric centers. These asymmetric centers may independently be in either the R or S configuration. It will be apparent to those skilled in the art that certain compounds of the invention may also exhibit geometrical isomerism. It is to be understood that the present invention includes individual geometrical isomers and stereoisomers and mixtures thereof, including racemic mixtures, of compounds the present invention. Such isomers can be separated from their mixtures, by the application or adaptation of known methods, for example chromatographic techniques and recrystallisation techniques, or they are separately prepared from the appropriate isomers of their intermediates.
According to a further feature of the invention, acid addition salts of the compounds of this invention may be prepared by reaction of the free base with the appropriate acid, by the application or adaptation of known methods. For example, the acid addition salts of the compounds of this invention may be prepared either by dissolving the free base in water or aqueous alcohol solution or other suitable solvents containing the appropriate acid and isolating the salt by evaporating the solution, or by reacting the free base and acid in an organic solvent, in which case the salt separates directly or can be obtained by concentration of the solution.
The acid addition salts of the compounds of this invention can be regenerated from the salts by the application or adaptation of known methods. For example, parent compounds of the invention can be regenerated from their acid addition salts by treatment with an alkali, e.g. aqueous sodium bicarbonate solution or aqueous ammonia solution.
The starting materials and intermediates may be prepared by the application or adaptation of known methods, for example methods as described in the Reference Examples or their obvious chemical equivalents.
Aryl boronates of formula (XVII) wherein R- R-, P- and P- are as hereinbefore defined may be
prepared by reaction of compounds of formula (XVIII) wherein R1 R2-, P2- and P3- are as hereinbefore defined, with bis(pinacolato)boron in the presence of potassium acetate and [l,r-bis-(diphenylphosphino)ferroceno]-dichloropalladium (II) in an inert solvent, such as dioxane, at and at a temperature at about 80°C.

Compounds of formula (XVIII) wherein R- and R- are as hereinbefore defined and P- and P-- are both tertiary-butoxycarbonyl may be prepared by reaction of compounds of formula (XXIX):-

wherein R- and R- are as hereinbefore defined with sodium hydride and di-tertiary-butyliminodicarboxylate, in an inert solvent, such as tetrahydrofuran, and at a temperature at about room temperature.
Intermediates of formulae (VIII) and (XV) are novel compounds and, as such, they and their processes described herein for their preparation constitute further features of the present invention.
The present invention is further Exemplified but not limited by the following illustrative Examples and Reference Examples.
In the nuclear magnetic resonance spectra (NMR) the chemical shifts are expressed in ppm relative to tetramethylsilane. Abbreviations have the following significances: br = broad, dd - double doublet, s = singlet; m - multiplet.
High Pressure Liquid Chromatography/ Mass Spectrometry (LC-MS) conditions for determination of retention times (Rj) were as follows: 3 micron Luna C18 (2) HPLC column (30mm x 4.6mm) eluting
with (i) mixture of 0.05% trifluoroacetic acid in acetonitrile and 0.05% trifluoroacetic acid in water (1:19, v/v) for 2 minutes, (ii) mixture of 0.05% trifluoroacetic acid in acetonitrile and 0.05% trifiuoroacetic acid in water (1:19 to 19:1, v/v) gradient elution over 10 minutes, (iii) mixture of 0.05% trifiuoroacetic acid in acetonitrile and 0.05% trifluoroacetic acid in water (19:1, v/v) for 2 minutes, (iv) mixture of 0.05% trifluoroacetic acid in acetonitrile and 0.05% trifluoroacetic acid in water (1:19 to 1:19, v/v) gradient elution over 2 minutes; flow rate 2ml/minute with approximately 200|.il/minute split to the Mass Spectrometer; injection volume 10-40-1; in line Diode Array (220-450nm), in line Evaporative light scattering (ELS) detection ELS - temperature 50°C, Gain 8 -l.8ml/minute; Source temperature 150°C.

The present invention may be better understood by reference to the following non-limiting Examples, which are provided as exemplary of the invention. The following examples are presented in order to more fully illustrate particular embodiments of the invention. They should in no way be construed, however, as limiting the broad scope of the invention.
In the nuclear magnetic resonance spectra (NMR), reported infra, the chemical shifts are expressed in ppm relative to tetramethylsilane. Abbreviations have the following significances: br = broad, dd =-double doublet, s = singlet; m = multiplet.
Moreover, in the Examples, High Pressure Liquid Chromatography/ Mass Spectrometry (LC-MS) conditions for determination of retention times (Rj) were as follows: 3 micron Luna CI 8 (2) HPLC
column (30mm x 4.6mm) eluting with (i) mixture of 0.05% trifluoroacetic acid in acetonitrile and 0.05% trifluoroacetic acid in water (1:19, v/v) for 2 minutes, (ii) mixture of 0.05% trifluoroacetic acid in acetonitrile and 0.05% trifluoroacetic acid in water (1:19 to 19:1, v/v) gradient elation over 10 minutes, (iii) mixture of 0.05% trifluoroacetic acid in acetonitrile and 0.05% trifluoroacetic acid in water (19:1, v/v) for 2 minutes, (iv) mixture of 0.05% trifluoroacetic acid in acetonitrile and 0.05% trifluoroacetic acid in water (1:19 to 1:19, v/v) gradient elution over 2 minutes; flow rate 2ml/minute with approximately 200-1/minute split to the Mass Spectrometer; injection volume 10-40-1; in line Diode Array (220-450nm), in line Evaporative light scattering (ELS) detection ELS - temperature 50°C, Gain 8 - 1.8ml/minute; Source temperature 150°C.
EXAMPLE 1 3-[l-(5-Phenvlethynvl-pvridine-3-carbonvn-piperidin-4-vl]-benzvlamine di-hvdrochloride (A.K.A. f4-(3-Aminomethyl-phenyn-piperidin-l-yl]-(5-phenylethynyl-pyridin-3-yl)-methanone) di-hydrochloride)
A. B-{3-[N,N--bis-(tert-butoxvcarbony-aminomethyl]phenyl}-pinacolato-boron A solution of 3-bromobenzylbromide (7.5g, 30mmol) and di-tert-butyliminodicarboxylate (6.5g, 30mmol) in anhydrous tetrahydrofuran (80ml) was treated portionwise with sodium hydride (1.2g, 60% dispersion in mineral oil). After stirring at ambient temperature for 7 hours the reaction mixture was partitioned between saturated aqueous ammonium chloride solution (90ml) and ethyl acetate (2 lots of 250ml). The combined organic layers were washed with brine (75ml), then dried over magnesium sulfate and then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of pentane and dichloromethane (2:1, v/v) to give 3-[N,N--bis-(/-r/-butoxycarbonyl)aminomethyl]-bromobenzene as a pale yellow oil (9.52g). A sample

of this material (2.0g, 5.2mmol) was dissolved in anhydrous dimethylsulfoxide (30ml) and the solution was treated with potassium acetate (1.52g, 15.5mmol), bis(pinacolato)diboron (1.45g, 5.7mmoI), and [l,r-bis-(diphenylphosphino)ferroceno]-dichloropalladium (Il)-dichloromethane complex (0.13g, 0.16mmol). This mixture was stirred at 80°C under an atmosphere of nitrogen for 5 hours, then cooled and then partitioned between water (100ml) and diethyl ether (4 lots of 75ml). The combined organic layers were washed twice with brine (75ml), then dried over magnesium sulfate and then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of pentane and dichloromethane (2:1, v/v) to give g-(3-riV.A--bis-f-gr-butQxycarbonvn-aminomethvl1-
phenvU-pinacolato-boron as a colorless oil (1.08g). -H NMR (CDCI3, 500 MHz); 6 7.78 (s, 1H), 7.70 (m, 1H), 7.39 (m, 1H), 7.30 (m, 1H), 4.79 (s, 2H), 1.27 (s, 18H), 1.35 (s, 12H). MS(EI): 434(M++H).
B. 4-l3-[A-.yV-Bis-tor-butoxvcarbonvl)aminomethyn-phenvl}-piperidine
A solution of lithium diisopropylamine (54mmol) in anhydrous tetrahydrofuran (50ml), at -78°C, was treated dropwise with a solution of benzyl 4-oxo-l-piperidinecarboxylate (11.4g, 49mmol) in anhydrous tetrahydrofuran (50ml). This mixture was stirred at -78°C for 20 minutes and then treated with a solution of N-phenyltrifluoromethanesulfonimide (19.26g, 54mmoI) in anhydrous tetrahydrofuran (55ml). The resultant orange suspension was warmed to O--C, then stirred at 0°C for 2 hours and then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with dichloromethane to yield benzyl l,2,3,6-tetrahydro-4-(trifluoromethylsulphonyloxy)-pyridine-1-carboxylate as a yellow oil (11.34g). A portion of this material (0.84g, 2.3mmol) was dissolved in anhydrous dimethylformamide (20ml) and the solution was treated with 5-{3-[A-,A--bis-(tert-butoxycarbonyl)aminomethyl]-phenyl-pinacolato-boron (l.Og, 2.3mmol), potassium carbonate (0.96g, 6.7mmol) and [l,r-bis-(diphenylphosphino)ferroceno]dichloropalladium (Il)-dichloromethane complex (O.lg, O.Mmmol). This mixture was heated at 80°C under an atmosphere of nitrogen for 18 hours, then cooled and then concentrated under vacuum. The residue was partitioned between ethyl acetate (2 lots of lOOml) and water (100ml) containing concentrated ammonium hydroxide (6ml). The combined organic extracts were dried over magnesium sulfate and then concentrated under vacuum. The resultant oil was subjected to chromatography on silica gel eluting with a mixture of ethyl acetate and pentane (1:4, v/v) to yield a yellow oil (0.9g). This material was dissolved in ethanol (20ml) and the solution was treated with 10% palladium on carbon (20 mg) then stirred at ambient temperature under an atmosphere of hydrogen for 5 hours. The reaction mixture was filtered through a short pad of hyflo and the filtrate was concentrated under vacuum to give 4-i3-[N.N-b\s-(tert-
butoxycarbonvDaminomethyn-phenvll-piperidine as colorless oil (0.54g). - H NMR (CDCI3, 500
MHz): 6 7.10 (m, 4H), 4.80 (s, 2H), 4.45 (br m,lH), 3.20 (br m, - 2.98 (br m, - 2.75 (br m, 1H),
1.90 (m, - 1,75-1.60 (m,3H), 1.42 (s, 18H), MS(EI): 391(M++H).

C. MA--Bis-(tert-butQxycarbonyn-3-[l-(5-phenvlethvnvl-pvridine-3-carbonvl)-piperidin-4--
benzylamine
A solution of 5-phenyIethynyl-pyridine-3-carboxylic acid (0.25g, l.lmmol) in anhydrous dimethylformamide (5ml) was treated with 0-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate (0.42g, 1.1 mmol) and diisopropylethylamine (0.5ml, 3mmol). This mixture was stirred 15 minutes at ambient temperature and then treated with a solution of 4-{3-[A-,A--Bis-(tert-butoxycarbonyl)aminomethyl]-phenyl}-piperidine (0.39g, l.Ommol) in dimethylformamide (5ml). After stirring at ambient temperature for 18 hours the reaction mixture was concentrated under vacuum. The residue was partitioned between ethyl acetate (50ml) and saturated aqueous sodium bicarbonate (15ml). The organic layer was dried over magnesium sulfate and then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of dichloromethane and methanol (49:1, v/v) to give MA--bis-(tert-butoxvcarbonvl)-3-[l-(5-
phenvlethynyl-pvridine-3-carbonvn-piperidin-4-yl]-benzylamine as a yellow oil (0.25g). -HNMR [(CD3)2SO, 500 MHz]: 6 8.82 (s, - 8.62 (s, - 8.02 (s, - 7.61 (m, 2H), 7.45 (m, 3H), 7.30 (m,
- 7.20 (m, - 7.15 (m, - 7.04 (m, - 4.68 (s, 2H), 4.62 (br m, - 3.60 (br m, - 3.23 (br
m, - 2.85(m, 2H), 1.83 (brm, - 1.65 (m,3H), 1.39 (s, 18H). MS(EI): 596(M++H).
D. 3-[ I -(5-Phenylethvnvl-pvridine-3-carbonvl)-piperidin-4-vlVbenzvlamine di-hydrochloride
A solution of 3-[l-(5-phenylethynyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzonitrile (0.15g,
0.25mmol) in ethyl acetate (20ml) was cooled to 0°C and then saturated with hydrogen chloride gas.
The reaction mixture was stirred at ambient temperature for 4 hours and then concentrated to dryness
under vacuum. The residue was treated with ethyl acetate (10ml) and the solvent removed under
vacuum. This process was repeated twice to give 3-[l-(5-phenvlethvnyl-pyridine-3-Carbonyn-
piperidin-4-yl]-benzylamine di-hydrochloride as a white solid (0.1 Ig). -HNMR [(€03)280, 500
MHz]: 8 8.83(8, - 8.63(s, - 8.08(s, - 7.61 (m, 2H), 7.45 (m, 3H), 7.44 (s, - 7.37(m, 3H), 4.64 (brm, - 4.00 (m, 2H), 3.62 (brm, - 3.25 (brm, - 2.90 (br m, 2H), 1.88 (brm, -
1.70 (m,3H). MS(EI): 396(M++H).
EXAMPLE 2 3-[ 1 -(5-Phenylethyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine di-hydrochloride (A.K.A. [4-(3-Aminomethyl-phenvn-piperidin-1-vl]-(5-phenethyl-pyridin-3-yl)-methanone di-hydrochloride)
A. 5-Phenvlethyl-pvridine-3-carboxylic acid

A solution of 5-phenylethynyI-pyridine-3-carboxylic acid (2g, 8.9mmol) in tetrahydrofuran (50ml) was treated with 10% palladium on carbon (200 mg) and stirred at ambient temperature under an atmosphere of hydrogen for 5 hours. The reaction mixture was filtered through a short pad of hyflo and the filtrate was concentrated under vacuum to give 5-phenylethyl-pvridine-3-carboxvlic acid as
white solid (2g). -HNMR [(CD3)2SO, 500 MHz]: 6 8.90 (m, - 8.60(m, - 8.12(m, - 7.21
(m, 5H), 3.38 (br s, 1H), 2.95 (m, 4H).
B. A-.#-Bis-(/err-butoxvcarbonvl-)-3-ri-(5-phenylethyl-pvridine-3-carbonyl)-piperidin-4-yl]-
benzylamine
By proceeding in a similar manner to the method described in EXAMPLE IC, but using of 5-phenylethyl-pyridine-3-carboxylic acid in place of 5-phenylethynyl-pyridine-3-carboxylic acid, there was prepared jV,A--bis-(tert-butoxycarbonyl)-3-ri-(5-phenylethvl-pvridine-3-carbonyl)-piperidin-4-yl]-
benzylamine as a white amorphous solid. -HNMR [(CD3)280, 500 MHz]: 5 8.50 (s, - 8.41 (s,
1H), 7.61 (m, - 7.30-7.05 (m, 9H), 4.68 (s, 2H), 4.62 (br m, - 3.48 (br m, - 3.35 (s, 4H), 3.18 (br m, 1H), 2.85 (m, 2H), 1,82 (br m, 1H), 1,65 (br m, - 1.58 (br m, 2H), 1.39 (s, 18H). MS(EI):
600(M++H).
C. 3-[l-(5-Phenylethyl-pvridine-3-carbonyl)-piperidin-4-yl]-benzylamine di-hydrochloridc
By proceeding in a similar manner to the method described in EXAMPLE 1D, but using iV,JV-bis-(rer-butoxycarbonyl)-3-[l-(5-phenylethyl-pyridine-3-carbonyl)-piperidin-4-yI]-benzylamine in place of A-.A--Bis-(tert-butoxycarbonyl)-3-[l-(5-phenylethynyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine, there was prepared 3-[ 1 -(5-phenvlethyl-pyridine-3-carbonyl)-piperidin-4-yl]-
benzylamine di-hvdrochloride as a white solid. -H NMR [(CD3)280, 500 MHz]: 8 8.90 (m, 2H), 8.42
(s, 1H), 7.58 (m, 1H), 7.38-7.20 (m, 8H), 4.62 (br m, 1H), 4.00 (m, 2H), 3.45 (br m, 1H), 3.20 (br m, 1H), 3.17 (m, 2H), 3.00 (m, 2H), 2.90 (br m, 2H), 1.88 (br m, 1H), 1.70 (br m, 3H). MS(EI):
400(M++H).
EXAMPLE 3 3-[ I -(1 -oxy-5-phenylethyl-pvridine-3-carbonyn-piperidin-4-vl]-benzylamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(l-oxy-5-phenethyl-pyridin-3-yl)-methanone hydrochloride)
A solution of N,N--Bis-(rer-butoxycarbonyl)-3-[l-(5-phenylethyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine (lOOmg, 0.17mmol EXAMPLE 2B) in dichloromethane (10ml) was treated with meta-chloroperbenzoic acid (80%, 80mg, 0.37mmol). After stirring for 18 hours at ambient temperature the reaction mixture was diluted with dichloromethane (40ml) and then washed three times with saturated

aqueous sodium bicarbonate solution (20ml). The organic phase was dried over magnesium sulfate and then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of dichloromethane and methanol (98:2, v/v) to give N,N-biS-(tert-butoxycarbonyl)-3-[l-(l-oxy-5-phenylethyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine as a colorless oil (70mg). This material was dissolved in ethyl acetate (lOml) and the solution was cooled to 0°C, then saturated with hydrogen chloride gas, then stirred at ambient temperature for 4 hours and then concentrated to dryness under vacuum. The residue was treated with ethyl acetate (10ml) and the solvent removed under vacuum. This process was repeated twice to leave the title compound as a
white solid (45mg). -HNMR [(003)280, 500 MHz]: 6 8.39 (s, - 8.30(s, - 7.45(s, - 7.40
(s, 1H), 7.38-7.18 (m, 8H), 4.59 (br m, 1H), 4.00 (m, 2H), 3.50 (br m, 1H), 3.20 (br m, 1H), 2.98 (s,
4H),2.85(brm,2H), 1.84 (brm, - 1.68 (br m, 3H)- MS(El): 416(M++H).
EXAMPLE 4 3-[l-(Ouinoline-3-carbonvn-piperidin-4-vl]-benzylaminedi-hvdrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-quinolin-3-yl-methanone di-hydrochloride) By proceeding in a similar manner to the method described in EXAMPLE I, but using quinoline-3-carboxylic acid in place of 5-phenylethynyl-pyridine-3-carboxylic acid, there was prepared the title
compound as a white amorphous solid. -HNMR [(CD3)280, 500 MHz]: 8 9.10 (s, - 8.78(s, -
8.20 (m, 2H), 7.98 (m, 1H), 7.80 (m, 1H), 7.50 (s, 1H), 7.35 (m, 3H), 4.72 (br m, 1H), 4.00 (m, 2H), 3.80 (br m, - 3.30 (br m, - 2.90 (br m, 2H), L90(brm, - 1.75 (br m, 3H). M8(E1):
346(M++H).
EXAMPLE 5 3-[ 1 -(3-Phenvlethynvl-benzovn-piperidin-4-vl]-benzylamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(3-phenylethynyl-phenyl)-methanone hydrochloride)
A. yV,A--Bis-(tert-butoxycarbonyn-3-[l-(3-ethvnyl-benzovn-piperidin-4-yl]-benzvlamine By proceeding in a similar manner to the method described in EXAMPLE IC, but using of 3-ethynyl-benzoic acid [prepared according to the procedure described by C. Eaborn et al., J. Chem. Soc. C, 1967, (15), pages 1364-1366] in place of 5-phenylethynyl-pyridine-3-carboxylic acid, there was prepared jV.7V-bis-(/er/-butoxvcarbonyn-3-[l-(3-ethynyl-benzoyn-piperidin-4-yl]-benzylamine as a
white amorphous solid. -H NMR (COCI3, 500 MHz): 6 7.76 (m, 2H), 7.40 (m, 2H), 7.25 (m, 2H),
7.10(m,4H),4.95(brm,lH),4.79(s,2H),3,80(brm, - 3.10 (brm, - 2.84 (brm, lH),2.78(br
m, - 1.90 (m, - 1.75 (m,3H), 1.42 (s, 18H). M8(EI): 541(M-+Na).

B. A-,A--Bis-(tert-butoxycarbonyn-3-[l-(3-phenylethynyl-benzoyl)-piperidin-4-yl]-benzylamine
A mixture of-N,N-bis-(rer-butoxycarbonyl)-3-[l-(3-ethynyl-benzoyI)-piperidin-4-yl]-benzylamine (0.24g, 0.46mmol), iodobenzene (95mg, 0.46mmol), dichlorobis(triphenylphosphine)palladium (II) (35mg, O.OSmmoI), copper (I) iodide (26mg, 0.14mmol), triethylamine (0.57ml, 4.1mmol) and anhydrous dimethylformamide (8ml) was stirred at ambient temperature under nitrogen for 18 hours. The solvent was removed under vacuum and the residue was partitioned between ethyl acetate (3 lots of 50ml) and water (20ml). The combined organic layers were washed with brine (50ml), then dried over magnesium sulfate and then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of cyclohexane and ethyl acetate (3:2, v/v) to give AA,A--bis-(/grNbutoxycarbonyl)0-[l-(3-phenylethynyl-benzovn-piperidin-4-vl]-benzylamine as a
yellow oil (0.23g). * H NMR (CDCI3, 500 MHz): 6 7.58 (m, 4H), 7.40 (m, 5H), 7.25 (m, 1H), 1.10
(m, 3H), 4.90 (br m,lH), 4.79 (s, 2H), 3.80 (br m, - 3.15 (br m, - 2.84 (br m, 1H), 2.78 (br m,
- 1.95(m, - 1.80(m,3H), 1.42(s, 18H). MS(EI): 6I7(M++Na).
C. 3-[l-(3-Phenylethynyl-benzoyl)-piperidin-4-yl1-benzy|amine hydrochloride
A solution of A-,A--Bis-(rer-butoxycarbonyl)-3-[l-(3-phenylethynyl-benzoyl)-pipe-idin-4-yl]-benzylamine (lOOmg, 0.17mmol) in methanol (10ml), cooled to 0 °C, was saturated with hydrogen chloride gas. The mixture was stirred at ambient temperature for 4 hours then concentrated to dryness under vacuum. The residue was triturated with a mixture of dichloromethane and diethyl ether to give 3-[l-(3-phenylethynyl-benzoyl)-piperidin-4-yl]-benzylamine hydrochloride as a white amorphous
solid (46mg). -H NMR [CD3)280, 500 MHz]: 5 7.61-7.30 (m, 13H), 4.62 (br m, - 4.00 (s, 2H),
3.62 (brm, - 3,25 (br m, - 2.85 (br m, 2H), 1.88 (brm, - 1.70 (br m, 3H). MS(EI):
395(M++H).
EXAMPLE 6 2-l3-[4-(3-AminQmethyl-phenyn-piperidine-l-Carbonyl1-phenyl}-l-(4-hydroxyphenyl)-ethanQne (A.K.A. 2-{3-[4-(3-Aminomethyl-phenyl)-piperidine-l-carbonyl]-phenyI}-l-(4-hydroxy-phenyl)-ethanone hydrochloride)
A. N,N-Bis-(/gr-butoxycarbonv--3-ll-[3-(4-hydroxvpheny-ethvnvl■benzoyl1-piperidin-4-yl|-
benzylamine
By proceeding in a similar manner to the method described in EXAMPLE 5B, but using 4-iodophenol
in place of iodobenzene, there was prepared N,N-bis-(tert-butoxycarbonyn-3-{l-[3-(4-
hydroxvphenyl)ethynyl-benzoyl]-piperidin-4-yl}-benzvlamine as a yellow amorphous solid. * H NMR

(CDCI3, 500 MHz): 5 7.58 (m, 2H), 7.40 (m, 4H), 7.25 (m, - 7.15 (m, 3H), 6.80 (m, 2H), 4.90 (br m,lH), 4.79 (s,2H), 3.90 (brm, - 3.15 (br m, - 2.84 (br m, - 2.78 (br m, - 1.98(m, -1.80 (m,3H), 1.42 (s, 18H). MS(EI): 633(M++Na).
B. 2-|3-r4-(3-Aniinomethvl-phenvn-piperidine-l-carbonvl1-phcnvll-l-(4-hvdroxvphenyl)-ethanone
hydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 5C but using N,N-h\s-{tert-
butoxycarbonyl)-3-{ 1 -[3-(4-hydroxyphenyl)ethynyl-benzoyl]-piperidin-4-yl}-benzylamine, there was
prepared 2-(3-[4-(3-aminomethvl-phenvn-piperidine-l-carbonvl]-phenvil-l-(4-hvdroxvphenvn-
ethanone hydrochloride as a white amorphous solid. - H NMR [(€03)280, 500 MHz]: 6 7.92 (m, 2H), 7.40-7.28 (m, 8H), 6.82 (m, 2H), 4.60 (br m, - 4.38 (s, 2H), 4.00 (s, 2H), 3.62 (br m, - 3.18 (brm, - 2.80(brm, 2H), 1.88 (brm, - 1.70-1.60 (br m, 3H), MS(EI): 429(M++H).
EXAMPLE 7 3-11 -[3-(6-Amino-pyridin-3-yl)ethvnyl-benzoyl]-piperidin-4-yl}-benzylamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-[3-(6-amino-pyridin-3-y!ethynyl)-phenyl]-methanone hydrochloride)
A. 3-lodo-6-(rgrr-butoxycarbonvlamino)pyridine
A stirred solution of 6-amino-3-iodopyridine (0.44g, 2.0mmol) in anhydrous tetrahydrofuran (7ml), under nitrogen, was treated dropwise with a solution of sodium bis(trimethylsilyl)amide (IM, 4.4ml, 4.4mmol). After stirring for a further 15 minutes the mixture was treated with a solution ofdl-tert-butyldicarboxylate (440 mg, 2mmol) in anhydrous tetrahydrofuran (3ml). The resulting thick slurry was stirred at ambient temperature for 18 hours then partitioned between ethyl acetate (3 lots of 50ml) and water (50ml). The combined organics were dried over sodium sulfate then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of cyclohexane and ethyl acetate (9:1, v/v) to give 3-iodo-6-(-gr-butoxycarbonylamino)pyridine as a white solid (0.56g). -H NMR (CDCI3, 500MHz) 58.50 (s, 1H), 7.92 (m, 1H), 7.85 (m, 1H), 1.58 (s,
9H). MS(E1):319(M--H).
B. N,N-Bis-(tert-butoxycarbonyn-3-{ 1 -[3-(6-rgr/-butoxycarbonylamino-pyridin-3-ynethvnvl-
benzoyl]-piperidin-4-yl}-benzvlamine
By proceeding in a similar manner to the method described in EXAMPLE 5B, but using 3-iodo-6-(tert-butoxycarbonylamino)pyridine in place of iodobenzene, there was prepared N,N--bis-(tert-butQxycarbonyn-3-ll-[3-(6-tert-butoxycarbonylamino-pyridin-3-vl)ethynyl-benzoyl1-piperidin-4-yl}-

benzvlamine as a yellow amorphous solid. 1H NMR (CDCI3, 500MHz): 6 8.41 (s, 1H), 7.99 (m, 1H),
7.80 (m, - 7.61 (s, - 7.59 (m, 2H), 7.40 (m, 2H), 7.23 (m, - 7.12 (m, 3H), 4.90 (br m,lH), 4.79 (s, 2H), 3.84 (brm, - 3.15 (br m, - 2.84 (br m, - 2.78 (br m, - 1.95(m, - 1.80(m,
3H) 1-55 (s, 9H), 1.42 (s, 18H). MS(El): 710(M+).
C. 3-{ l-[3-(6-Amino-pyridin-3-vl)ethvnvl-benzovl]-piperidin-4-vll-benzvlamine hydrochloride By proceeding in a similar manner to the method described in EXAMPLE 5C but using A-,A--bis-(/erN butoxycarbonyl)-3-{l-[3-(6-/er/-butoxycarbonylamino-pyridin-3-yl)ethynyl-benzoyl]-piperidin-4-yl}-benzylamine, there was prepared 3-(l-r3-(6-Amino-pvridin-3-vnethvnvl-benzovl1-piperidin-4-vl}-
benzylamine hydrochloride as a white amorphous solid.). -HNMR [(003)280, 500 MHz]: 5 8.22
(s, - 8.15 (brs,2H), 7.90 (m, - 7.60-7.41 (m, 5H), 7.30 (m, 3H), 6.93 (m, - 4.60 (br m, -4.00 (m,2H), 3.62 (brm, - 3.25 (brm, - 2.85 (br m, 2H), 1.84 (brm, - 1.60 (br m, 3H).
MS(EI):411(M++H).
EXAMPLE 8 3-{l-[3-(4-hvdroxvmethvlphenvnethvnyl-benzovl1-piperidin-4-vl{-benzvlamine hydrochloride (A.K.A. [4-(3-AminomethyUphenyl)-piperidin-l-yl]-[3-(4-hydroxymethyl-phenylethynyl)-phenyl]-methanone hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 5, but using 4-iodobenzylalcohol (prepared according to the procedure described by D.S.Tan et al., J. Am. Chem. Soc, 1998, 120(33), pages 8565-8566) in place of iodobenzene, there was prepared the title
compound as a white amorphous solid. -H NMR [(€03)280, 500 MHz]: 5 7.61-7.25 (m, I2H), 5.33
(m, 1H), 4.62 (br m, 1H), 4.58 (m, 2H), 4.00 (s, 2H), 3.62 (br m, 1H), 3.20 (br m, - 2.83 (br m, 2H),
1.84 (brm, - L72-L62 (br m, 3H). MS(EI): 425(M++H).
EXAMPLE 9
3-[ 1 -(3-Phenylethvl-benzovl)-piperidin-4-yn-benzvlamine hydrochloride
(A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(3-phenethyl-phenyl)-methanone hydrochloride) A solution of A-,A--bis-(/--A--butoxyca-bonyl)-3-[l-(3-phenylethynyl-benzoyl)-piperidin-4-yl]-benzyIamine (1 lOmg, 0.18mmol, EXAMPLE 53) in ethanol (10ml) was treated with 10% palladium on carbon (20mg) and then stirred at ambient temperature under an atmosphere of hydrogen for 8 hours. The reaction mixture was filtered through a short pad of hyflo and then concentrated under vacuum to give a white amorphous solid (0.54g). This material was treated with methanolic hydrogen chloride according to the procedure described in EXAMPLE 5C to give the title compound as white
amorphous solid (25mg). -HNMR [(CD3)280, 500 MHz]: 6 7.40-7.15 (m, 13H), 4.62 (br m, -

4.00(s, 2H), 3.60(brm, - 3.10 (br m, - 2.80 (br m, 2H), 1.85 (brm, - 1.60(brm, SH), MS(EI): 399(M++H).
EXAMPLE 10 3-ll-f3-(4-hvdroxvphenv!)ethvl-benzQyl]-pipcridin-4-vl}-benzvlamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-{3-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 9, but using N,N-bis-{tert-butoxycarbonyI)-3-{ 1 -[3-(4-hydroxyphenyl)ethynyl-benzoyl]-piperidin-4-yl j-benzylamine
(EXAMPLE 6A), there was prepared the title compound as a white amorphous solid. - H NMR [(CD3)2SO, 500 MHz]; 8 9.18 (br s, - 7.41 (s, - 7.35 (m, 5H), 7.20 (m, 2H), 6.98 (m, 2H), 6.60
(m, 2H), 4.82 (br m,- 4.00 (m, 2H), 3.80 (br m, 1H), 3.10 (br m, 1H), 2.80 (m, 6H), 1.82 (br m,
- 1.70 (brm, - 1.60 (br m, 2H). MS(EI): 415(M++H).
EXAMPLE 11 3-ll-[3-f6-amino-pyridin-3-vl)ethvl-benzoyl]-piperidin-4-vl)-benzvlamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-{3-[2-(6-amino-pyridin-3-yl)-ethyI]-phenyl}-methanone hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 9, but using A-,A--bis-(/£-rr-butoxycarbonyl)-3-{l-[3-(6-/err-butoxycarbonylamino-pyridin-3-yl)ethynyl-benzoyl]-piperidin-4-yl}-
benzylamine (EXAMPLE 7B), there was prepared the title compound as a white amorphous solid. -H NMR [(CD3)2SO, 500 MHz]: 5 7.90 (br s, 2H), 7.85 (m, - 7.76 (s, - 7.43 (s, - 7.40-7.30
(m, 5H), 7.24 (m, 2H), 6.93 (m, 1H),4.61 (brm, - 4.00 (m, 2H), 3.60 (brm, - 3.15 (br m, -
2.92(brm,6H), 1.90 (brm, - 1.70 (brm, - 1.60 (brm, 2H). MS(EI): 415( M++H).
EXAMPLE 12 3,[]-(4-Phenvlethvl-thiophene-2-carbonvl)-piperidin-4-vl]-benzvlamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(4-phenethyl-thiophen-2-yl)-methanone hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 1, but using 4-phenylethyl-thiophene-2-carboxyIic acid (prepared according the procedure described by S.Gronowitz et al., Heterocycles, 1981, 15(2), pages 947-959) in place of 5-phenylethynyl-pyridine-3-carboxylic acid,
there was prepared the title compound as a white amorphous solid. -HNMR [(€03)280, 500 MHZ]: 6 7.41-7.18 (m, 1 - 4.37 (br m, - 4.00 (m, 2H), 3.05 (br m, 2H), 2.98 (s, 4H), 2.85 (br m, 2H), 1.90 (br m, 2H), 1.60 (br m, 2H), MS(EI): 405(M++H).

EXAMPLE 13 3-[l-(5-Phenvlethvl-thiophene-2-carbonvn-pipcridin-4-vl1-benzvlamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(5-phenethyl-thiophen-2-yl)-methanone hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 2, but using 5-phenyIethynyl-thiophene-2-carboxylic acid in place of 5-phenylethynyl-pyridine-3-carboxylic acid,
there was prepared the title compound as a white amorphous solid. -H NMR [(003)280, 500 MHz]:
5 7.4! (s, - 7.38-7.20 (m, 9H), 6.83 (s, - 4.40 (br m, - 4.00 (br s, 2H), 3.12 (m, 2H), 3.08 (br
m, 2H), 2.98 (m, 2H), 2.85 (br m, 2H), 1.82 (br m, 2H), 1.60 (br m, 2H), MS(EI): 405(M--+H).
EXAMPLE 14 3-11 -[3-(Benzooxazo-2-vlVben20vl]-piperidin-4-yl}-benzylamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(3-benzoxazol-2-yl-phenyl)-methanone hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 1, but using 3-(benzooxazo-2-yl)-benzoic acid (prepared according to the procedure described by V.F.Bystrov et al., Zh. Obshch, Khim., 1968, 38(5), pages 1001-1005) in place of 5-phenylethynyl-pyridine-3-carboxylic acid, there
was prepared the title compoun_d as a white amorphous solid. -H NMR [(€03)280, 500 MHz]: 6
8.28 (m, - 8.19 (s, - 7.81 (m, 2H), 7.50 (m, 2H), 7.43 (m, 3H), 7,30 (m, 3H), 4.66 (br m, -4.00(m, 2H), 3.70(brm, - 3.25 (br m, - 2.92 (br m, - 2.82 (br m, - 1.90 (brm, - 1.70
(brm,3H), MS(EI): 412(M--+H).
EXAMPLE 15 3-[l-(3-PhenQxymethyl-benzoyl)-piperidin-4-yl1-benzylamine hydrochloride (A.K.A, [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(3-phenoxymethyI-phenyl)-methanone hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 1, but using 3-phenoxymethyl-benzoic acid (prepared according to the procedure of H.Oelschlaeger et al.. Arch. Pharm. (Weinheim, Ger.), 1978,311(2), pages 81-97) in place of 5-phenylethynyl-pyridine-3-
carboxylic acid, there was prepared the title compound as a white amorphous solid. -H NMR [(CD3)2SO, 500 MHz]: 5 7.58-7.25 (m,10H), 7.00 (m, 2H), 6.96 (m, - 5.18 (s, 2H), 4.62 (br m,
- 4.00 (m,2H), 3.62 (brm, - 3.18 (brm, - 2.82 (brm, 2H), 1.88 (brm, - 1.65 (br m, 3H),
MS(El): 401(M--+H).

EXAMPLE 16 3-i 1 -[3-(2-E--Phenvlethenyl)-benzovl1-piperidin-4-yl)-benzylamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-[3-((E)-styryl)-phenyl]-methanone hydrochloride) By proceeding in a similar manner to the method described in EXAMPLE 1, but using 3-(2-E-phenylethenyl)-benzoic acid (prepared according to the procedure of N.A.Bumagin et al., Zh. Org. Khim., 1995, 31(4), pages48I-487) in place of 5-phenylethynyl-pyridine-3-carboxylic acid, there was
prepared the title compound as a white amorphous solid. -H NMR [(003)280, 500 MHz]: 6 7.71
(m, 1H), 7.63 (m, 3H), 7.50 (m, 2H), 7.40-7.25 (m, 9H), 4.63 (br m, 1H), 4.00 (s, 2H), 3.71 (br m, 1H),
3.10(brm, - 2.84 (br m, 2H), K88(brm, - L70(brm,3H), MS(EI): 397(M++H).
EXAMPLE 17 4-Fluoro-3-ri-(5-phenvlethvl-pvridine-3-carbonvn-piperidin-4-vl]-benzylamine di-hydrochloride (A.K.A. [4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-l-yl]-(5-phenethyl-pyridin-3-yl)-methanone di-hydrochloride)
A. 4-(Pinacolatoboronyn-K2J.6-tetrahydro-pyridine trifluoroacetate
A solution of lithium diisopropylamine (59mmol) in anhydrous tetrahydrofuran (50ml) at -78°C was treated dropwise with a solution of tert-butyl 4-oxo-l-piperidinecarboxylate (10.7g, 54mmol) in anhydrous tetrahydrofuran (70ml). After stirring at -18°C for a further 20 minutes the reaction mixture was treated with a solution of N-phenyltrifluoromethanesulfonimide (21.2g, 59mmol) in anhydrous tetrahydrofuran (90ml). The resultant orange suspension was warmed to 0°C, then stirred at 0°C for 3 hours and then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of pentane and dichloromethane (1:1, v/v) and then subjected to chromatography on alumina eluting with a mixture of pentane and ethyl acetate (9:1, v/v) to yield tert-butyl l,2,3,6-tetrahydro-4-(trifluoromethylsulphonyloxy)-pyridine-l-carboxylate as a yellow oil (15g). A portion of this material (1.72g, 5.2mmol) was dissolved in anhydrous dioxane (30ml) and the solution was treated with bis(pinacolato)diboron (1.46g, 5.75mmol), potassium acetate (1.54g, l5.7mmol), (diphenylphosphino)-ferrocene (86mg, 0.16mmol)and [l,r-bis-
(diphenylphosphino)ferroceno]-dichloropalladium (II) (I 14mg, 0.16mmol). The reaction mixture was heated at 80°C under an atmosphere of nitrogen for 18 hours, then cooled and then concentrated under vacuum. The residue was partitioned between ethyl acetate (2 lots of 100ml) and water (100ml). The combined organic extracts were dried over magnesium sulfate then concentrated under vacuum. The resultant oil was subjected to chromatography on silica gel eluting with a mixture of ethyl acetate and pentane (1:8, v/v) to yield a yellow oil (I.4g). A solution of this material in dichloromethane (lOmI), cooled to 0°C, was treated with trifluoracetic acid (3.9ml). The mixture was stirred at ambient temperature for 2 hours then concentrated under vacuum to leave 4-(pinacolatoborony|)-L2,3,6-

tctrahvdro-pvridine trifluoroacetate as a brown oil. -H NMR [(CD3)2SO, 500 MHz]: 6 8.76 (br s, 2H),6.39(brs, - 3.61 (br m, 2H), 3.11 (brm, 2H), 2.23 (brm, 2HX 1.20 (s 12H). MS(El): 210(M++H).
B. l-(5-Phenvlethvl-pyridine-3-carbonvn-4-(pinacolatoboronvl)-K2,3,6-tetrahvdro-pvridine
A solution of 5-phenylethyl-pyridine-3-carboxylic acid (0.46g, 2.0mmol, EXAMPLE 2A) in
anhydrous dimethylformamide (9ml) was treated with 0-(7-azabenzotriazol-l-yl)-l,l,3,3-
tetramethyluronium hexafluorophosphate (0.87g, 2.2mmol) and diisopropylethylamine (1.7ml,
lOmmoI). This mixture was stirred at ambient temperature for 10 minutes then treated with a solution
of 4-(pinacolatoboronyl)-l,2,3,6-tetrahydro-pyridine trifluoroacetate (O.81 2.5mmol) in
dimethylformamide (9ml). The reaction mixture was stirred at ambient temperature for 18 hours and
then concentrated under vacuum. The residue was partitioned between dichloromethane (2 lots of
50ml) and saturated aqueous sodium bicarbonate (15ml). The combined organic layers were dried
over magnesium sulfate and then concentrated under vacuum. The residue was subjected to
chromatography on silica gel eluting with ethyl acetate to give l-(5-phenvlethyl-pyridine-3-carbonvn-
4-(pinacolatoboronvl)-1.23,6-tetrahvdro-pvrldine as a brown amorphous solid (0.73g). - H NMR [(CD3)2SO, 500MHz]:6 8.49(s, lH),8.40(s, 1H),7.61 (s, - 7.20 (m, 5H), 6.48 (br s, -4.I8
(brm, - 3.83(brm, - 3.62 (br m, - 3.23 (br m, - 2.98 (m, 4H), 2.17 (br m, 2H), 1,20 (s,
12H). MS(El): 441(M++Na).
C. N-(tert-Boxvcarbonvn-3-bromo-4-fluoro-benzvlamine
A mixture of 3-bromo-4 fluoro-benzylamine hydrochloride (2.41g, lOmmoI), triethylamine (2.8ml, 20mmol), and di-tert-butoxycarbonate (1.8g, 10.3mmol) in dichloromethane (20ml) was stirred at ambient temperature for 18 hours then washed with water (20ml). The organic phase was dried over magnesium sulfate and then concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of cyclohexane and ethyl acetate (3:1, v/v) to give
N-(/erNbutoxvcarbonvn-3-bromo-4-fluQro-benzvlamineas a white solid (1.4g). -H NMR(CDCl3, 500 MHz): 5 7.45 (m, 1H), 7.20 (m, 1H), 7.08 (m, 1H), 4.85 (br s, 1H), 4.21 (m, 2H), 1.42 (s, 9H).
D. A--ftert-Butoxvcarbonyl)-4-fluoro-3-[l-(5-phenvlethvl-pvridine-3-carbonvn-1,23,6-tetrahydrQ-
pyridin-4-yn-benzylamine
A mixture of N-(/-rr-butoxycarbonyl)-3-bromo-4-fluoro-benzylamine (0.28g, 0.92mmol), anhydrous dimethylformamide (10ml), l-(5-phenylethyl-pyridine-3-carbonyl)-4-(pinacolatoboronyl)-1,2,3,6-tetrahydro-pyridine (0.37g, 0.88mmol), potassium carbonate (0.36g, 2.6mmol) and [1.1--bis-(diphenylphosphino)ferroceno]dichloropalIadium (Il)-dichloromethane complex (43 mg, 0.05mmol)

was heated at 80°C under an atmosphere of nitrogen for 18 hours. The reaction mixture was cooled to room temperature and then concentrated under vacuum. The residue was partitioned between ethyl acetate (2 lots of 50ml) and water (10ml). The combined organic extracts were dried over magnesium sulfate and then concentrated under vacuum. The resultant oil was subjected to chromatography on silica gel eiuting with ethyl acetate to yield A--(tert-butoxvcarbonyl)-4-fluoro-3-[ 1 -(5-phenylethyi-
pvridine-3-carbonvl)-1,2,3,,6-tetrahvdro-pvridin-4-vl]-benzylamincas a pale yellow oil (0.18g). - H NMR (CDCI3, 500 MHz): 5 8.58 (s, - 8.50 (s, - 7.51 (s, - 7.25 (m, 2H), 7.18 (m, 5H), 7.00
(m, 1H),6.01 (brs, - 4.83 (br s, - 4.38 (br m, - 4.27 (m, 2H), 3.98 (br m, 2H), 3.50 (brm,
1H), 2.99 (m, 4H), 2.60 (br m, 1H), 2.50 (br m, IH). MS(EI): 538(M++ Na).
E. 4-Fluoro-3-[ 1 -(5-phenvlethvl-pYridine-3-carbonvl)-piperidin-4-yl1-benzvlamine di-hydrochloride A solution of A--(rerr-butoxycarbonyl)-4-fluoro-3-[l-(5-phenyIethyl-pyridine-3-carbonyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-benzylamine in ethanol (12ml) was treated with 10% palladium on carbon (75mg) and the mixture was stirred at ambient temperature under an atmosphere of hydrogen for 72 hours. The reaction mixture was filtered through a short pad of hyflo and the filtrate was concentrated under vacuum to give 7V-(tert-butoxycarbonyl-4-fluoro-3-[l-(5-phenylethyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine as colorless oil (85mg). This material was dissolved in methanol (10ml) and the solution was cooled to O-C and then saturated with hydrogen chloride gas. This mixture was stirred at ambient temperature for 4 hours and then concentrated to dryness under vacuum. The residue was triturated with a mixture of dichloromethane and diethyl ether to give 4-fluoro-3-[l-(5-phenylethyl-pyridine-3-carbonvl)-piperidin-4-vl1-benzvlamine di-hydrochloride as a white amorphous
solid (50mg). IHNMR [(CD3)280, 500 MHz]: 6 8.60 (S, - 8.58(S, - 7.83(s, - 7.60(m,
1H), 7.38 (m, 1H), 7.20 (m, 6H), 4.61 (br m, - 4.00 (m, 2H), 3.50 (br m, - 3.20 (br m, 2H), 2.99
(m, 2H), 2.95 (m,2H), 2.90 (brm, - 1.82 (brm, - 1.65 (br m, 3H). MS(El): 418(M++H).
EXAMPLE 18 4-Methvl-3-[l-(5-phenvlethyl-pyridine-3-carbonyl)-piperidin-4-yl1-benzylamine di-hvdrochloride (A.K.A. [4-(5-Aminomethyl-2-methyl-phenyl)-piperidin-l-yl]-(5-phenethyl-pyridin-3-yl)-methanone di-hydrochloride)
A. 4-]NN,-Bis-(tert-butoxvcarbonvnaminomethvl]-2-bromo-toluene
A solution of 4-methyI-3-bromobenzylbromide (1.63g, 6.2mmol, prepared according to the procedure described in International Patent Application No. WO 0009475) and di-tert-butyliminodicarboxylate (1.48g, 6.8mmol) in anhydrous tetrahydrofuran (15ml) was treated portionwise with sodium hydride (0.27g of 60% dispersion in mineral oil, 6.8mmol). The mixture was stirred at ambient temperature for

18 hours then partitioned between saturated aqueous ammonium chloride solution (20ml) and ethyl acetate (3 lots of 80ml). The combined organic layers were washed with brine (80ml), then dried over magnesium sulfate and concentrated under vacuum. The residue was subjected to chromatography on silica gel eluting with a mixture of cyclohexane and diethyl ether (9:1, v/v) to give 4-[NM-h\s-(terh
butoxvcarbonynaminomethvl]-2-bromo-toluenc as a pale yellow oil (2.4g). - H NMR (CDCI3, 500
MHz): 5 7.45 (s, - 7.18 (m, 2H), 4.71 (s, 2H), 2.38 (s, 3H), 1.43 (s, 18H).
B. 4-Methyl-3-r 1 -(5-phenvlethyl-pvridine-3-Carbonyl)-piperidin-4-yl]-benzvlamine di-hydrochloride By proceeding in a similar manner to the method described in EXAMPLE 17, but using 4-[A-,A--bis-(tert-butoxycarbonyl)aminomethyl]-2-bromo-toluene in place of N-(tert-butoxycarbonyl)-3-bromo-4-fluoro-benzylamine, there was prepared 4-methvl-3-[l-(5-phenvlethyl-pyridine-3-carbonyn-piperidin-
4-vl1-benzylamine di-hydrochloride as a white amorphous solid. 1H NMR [(CD3)2SO, 500 MHz]: 5
8.60 (m, 2H), 7.83 (s, - 7.41 (s, - 7.20 (m, 7H), 4.62 (br m, - 3.98 (m, 2H), 3.45 (br m, 1H), 3.20 (br m, - 3.07 (m, 2H), 3.00 (m, 2H), 2.95 (m, 2H), 2.32 (s, 3H), 1.80 (br m, - 1.70 (br m,
3H). MS(EI): 414(M++H).
EXAMPLE 19 3-{l-[3-(5-Phenvl-l,3,4-oxadiazol-2-yl)-phenylcarbonyn-piperidin-4-yl}-benzvlamine hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-[3-(5-phenyl-l,3,4-oxadiazoU2-yl)-phenyI]-methanone hydrochloride)
A. 3-(5-Phenvl-,13,4-oxadiazQl-2-yl)-benzoic acid
A mixture of methyl hydrogen isopthalalate (1.8g, lOmmol), benzoic hydrazide (1.4g, lOmmol) and phosphorous oxychloride (20ml), under an atmosphere of nitrogen, was heated at ]20°C for 18 hours, then cooled to room temperature and then poured into ice water (500ml). This mixture was treated with solid sodium carbonate until the aqueous layer was basic (pH 8 -9) and the resultant pink solid was filtered. This material was treated with 100ml methanol and the suspension was treated with sodium hydroxide solution (30ml, IM). The reaction mixture was heated at reflux for 4 hours, then cooled and then concentrated to dryness. The residue was dissolved in water (100ml) and the solution was acidified to pH 3 by addition of concentrated hydrochloric acid. The resultant precipitate was filtered, then dried and then subjected to chromatography on silica gel eluting with a mixture of dichloromethane and methanol (98:2, v/v) to yield 3-(5-phenvl-1,L3.4-oxadiazol-2-yn-benzoic acid as a
white solid (600mg). -H NMR [CD3)280, 500 MHz]: 6 8.80 (s, - 8.38 (m, - 8.18 (m, 3H), 7.78 (m, - 7.62 (m, 3H). MS(EI): 265(M-- H).

B.3-{l-[3-(5-Phenyl-l,3,4-oxadiazol-2-vl)-phenvlcarbonyl]-piperidin-4--
hydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 1, but using 3-(5-phenyl-
l,3,4-oxadia2ol-2-yl)-benzoic acid in place of 5-phenylethynyl-pyridine-3-carboxylic acid, there was
prepared 3-{l-[3-(5-phenyl-K3,4-Oxadiazol-2-ylVphenylcarbonyl]-piperidin-4-yl}-benzylamine
hydrochloride as a pale yellow amorphous solid. -HNMR [(€03)280, 500 MHz]: 6 8.21 (m, -
8.20 (m, 3H), 7.75 (m, 2H), 7.68 (m, 3H), 7.50 (s, - 7.37 (m, 3H), 4.70 (br m, - 4.00 (m, 2H), 3.70 (brm, - 3.25 (br m, - 2.90 (br m, - 2.85 (br m, - 1.88 (brm, - 1.70(m,3H),
MS(EI): 439(M++H).
EXAMPLE 20 3-[]-(lndole-6-carbonyn-piperidin-4-yn-benzylamine trifluoroacetate
(A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(lH-indol-6-yl)-methanone trifluoroacetate) A solution of diisopropylamine in dimethylformamide (1ml, 180|iM) in a glass vial was treated with a solution of 0-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate in dimethylformamide (1ml, 60µM) followed by a solution of indole-6-carboxylic acid in dimethylformamide (1ml, 60µM). After standing at ambient temperature for 15 minutes the mixture was treated with a solution of 4-{3-[MA--bis-(tert-butoxycarbonyI)aminomethyl]-phenyl}-piperidine in dimethylformamide(lml, 60µM, EXAMPLE IB). The reaction mixture was allowed to stand at ambient temperature for 18 hours then evaporated. The residue was treated with chloroform (5ml) and aqueous sodium carbonate solution (5%). This mixture was shaken gently for 30 minutes, poured into a fritted polypropylene tube and the organic layer which passes through the frit collected in a glass vial. The chloroform was evaporated under vacuum and the residue was treated with a mixture of trifluoroacetic acid, dichloromethane and water (4ml, 55/40/5, v/v/v). This mixture was shaken gently for 2 hours and then evaporated to leave the title compound as a yellow oil. LC-MS: Rj = 3.43
minutes (>96% by ELSD); MS (ES+), 334 (MH+).
EXAMPLE 21 3-[ 1 -(Coumarin-3-carbonyl)-pipcridin-4-yl1-benzylamine trifluoroacetate
(A.K.A. 3-[4-(3-Aminomethyl-phenyl)-piperidine-l-carbonyl]-l-benzopyrA11-2-one trifluoroacetate) By proceeding in a similar manner to the method described in EXAMPLE 20, but using coumarin-3-carboxylic acid in place of indole-6-carboxylic acid, there was prepared the title compound as a yellow
oil. LC-MS: Rj - 3.15 minutes (>86% by ELSD); MS (ES+), 363 (MH+).
EXAMPLE 22

3-[ 1 -(Naphthvl-2-carbonvn-piperidin-4-vl1-benzvlamine trifluoroacetate
(A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-naphthalen-2-yl-methanone trifluoroacetate) By proceeding in a similar manner to the method described in EXAMPLE 20, but using 2-naphthoic acid in place of indole-6-carboxylic acid, there was prepared the title compound as a yellow oil. LC-
MS: RT = 3.66 minutes (100% by ELSD); MS (ES+), 345 (MH+).
EXAMPLE 23 3-{l-[3-(2-Naphthylthio)propionyl]-piperidin-4-yll-benzvlamine trifluoroacetate (A.K.A. l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-3-(naphthalen-2-ylsulfanyl)-propA11-l-one trifluoroacetate)
By proceeding in a similar manner to the method described in EXAMPLE 20, but using 3-(2-naphthylthio)propionic acid in place of indole-6-carboxylic acid, there was prepared the title
compound as a yellow oiL LC-MS: RT = 4.00minutes (>95% by ELSD); MS (ES+), 405(MH+).
EXAMPLE 24 3-{ I -[4-(lndol-3-yl)butanoyl]-piperidin-4-yL)-benzvlamine trifluoroacetate
(A.K.A. l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-4-(lH-indol-3-yl)-butA11-l-one trifluoroacetate) By proceeding in a similar manner to the method described in EXAMPLE 20, but using 4-(indol-3-yl)butanoic acid in place of indole-6-carboxylic acid, there was prepared the title compound as a
yellow oil. LC-MS: Rj = 3.64 minutes (>90% by ELSD); MS (ES+), 376(MH+).
EXAMPLE 25 3-{l-r4-(4-Biphenyl)-4-ketobutanoyl1-piperidin-4-yl}-benzvlamine trifluoroacetate (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-biphenyl-4-yl-methanone trifluoroacetate) By proceeding in a similar manner to the method described in EXAMPLE 20, but using 4-(4-biphenyl)-4-ketobutanoic acid in place of indole-6-carboxylic acid, there was prepared the title
compound as a yellow oil. LC-MS: Rj - 4.00 minutes (100% by ELSD); MS (ES--), 427(MH+).
EXAMPLE 26 3-[ 1 -(3-Benzvloxybenzoyl)-piperidin-4-vl]-benzvlamine trifluoroacetate (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(3-benzyloxy-phenyl)-methanone trifluoroacetate)
By proceeding in a similar manner to the method described in EXAMPLE 23, but using 3-benzyloxybenzoic acid in place of indole-6-carboxylic acid, there was prepared the tifle compound as a
yellow oil. LC-MS: Rj - 3.87 minutes (100% by ELSD); MS (ES+), 401 (MH+),

EXAMPLE 27 3-[1-(5-Phenvlethvnvl-thiophene-2-carbonvlLl)piperidin-4-vl]-benzvlamine trifluoroacetate (A.K.A. [4-(3-Aminomethyi-phenyI)-piperidin-l-yl]-(5-phenylethynyl-thiophen-2-yI)-methanone trifluoroacetate)
By proceeding in a similar manner to the method described in EXAMPLE 20, but using 5-phenyIethynyI-thiophene-2-carboxylic acid in place of indole-6-carboxylic acid, there was prepared the
title compound as a yellow oil. LC-MS: RT - 4.09 minutes (>97% by ELSD); MS(ES+), 410(MH+).
EXAMPLE 28 3-[l-(4-Phenylethvnvl-thiophene-2-carbonvn-piperidin-4-vn-ben2vlamine trifluoroacetate (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-]-yl]-(4-phenylethynyl-thiophen-2-yl)-methanone trifluoroacetate)
By proceeding in a similar manner to the method described in EXAMPLE 20, but using 4-phenylethynyl-thiophene-2-carboxylic acid in place of indole-6-carboxylic acid, there was prepared the
title compound as a yellow oil. LC-MS: R- == 4.08 minutes (>96% by ELSD); MS(ES--), 401(MH+).
EXAMPLE 29 3-(l-Benzovl-piperidin-4-vl)-benzvlamine trifluoroacetate
(A.K,A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-phenyl-methanone trifluoroacetate) By proceeding in a similar manner to the method described in EXAMPLE 20, but using benzoic acid in place of indole-6-carboxylic acid, there was prepared the title compound as a yellow oil. LC-MS:
Ry - 3.39 minutes (>95% by ELSD); MS(ES+) 295(MH+).
EXAMPLE 30 3-[l-(4-iV.iV-Dimethvlaminobenzovl)-piperidin-4-vn-benzv)amine trifluoroacetate (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-I-yl]-(4-dimethylamino-phenyI)-methanone trifluoroacetate)
By proceeding in a similar manner to the method described in EXAMPLE 20, but using 4-N,N-dimethylaminobenzoic acid in place of indole-6-carboxylic acid, there was prepared the title
compound as a yellow oil. LC-MS: Rj = 3.32 minutes (100% by ELSD); MS(ES--) 338(MH+).
EXAMPLE 31 6-Fluoro-3-fl-(5-phenvlethvl-pvridine-3-Carbonvn-piperidin-4-vl1-benzvlamine di-hydrochloride

(A.K.A. [4-(3-AminomethyI-4-fluoro-phenyl)-piperidin-l-yl]-(5-phenethyl-pyridin-3-yI)-methanone
di-hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 17, but using 3-bromo-6-
fluoro-benzylamine in place of 3-bromo-4-fluoro-benzyIamine, there was prepared the title compound
as a pale yellow oil. -H NMR [(CD3)280, 500 MHz]: 5 8.44 (m, 2H), 7.61 (s, lH),7.40(m, -
7.20 (m, 6H), 7.05 (m, - 4.62 (br m, 1H), 3.98 (m, 2H), 3.45 (br m, - 3.20 (br m, - 3.07 (m,
2HX 3.00 (m,2H), 2.95 (m,2H) 1.80 (brm, - h70(brm, 3H). MS(EI): 418(M++H).
EXAMPLE 32 l-(3-[l-(5-Phenylethyl-pyridine-3-carbonvl)-pipcridin-4-yn-phenyl)ethylamine di-hydrochloride (A.K.A, {4-[3-(l-Amino-ethyl)-phenyl]-piperidin-l-yl}-(5-phenethyl-pyridin-3-yl)-methanone di-hydrochloride)
By proceeding in a similar manner to the method described in EXAMPLE 17, but using l-(3-bromophenyl)ethylamine (prepared according to the procedure of C.P.Chen et al., Tetrahedron Letters, 199, 32(49), pages 7175-7178) in place of 3-bromo-4-fluoro-benzylamine, there was prepared
the title compound as a white solid. 1H NMR[(CD3)2SO, 500 MHz]: 6 8.62 (m, 2H), 7,95 (s, 1H),
7.50(s, - 7.20 (m,8H), 4,62 (brm, - 4.38 (t, J-6 Hz, lH),3.50(m, - 3.45 (br m, 1H),3.20 (brm, - 3.07 (m,2H), 3.00 (m,2H), 2.95 (m,2H), 1.87 (brm, - 1.65 (brm, 3H), 1.50(d,J=6
Hz,3H). MS(EI):414(M++H).
EXAMPLE 33
3-[l-(4-Hvdroxv-quinoline-3-carbQnvl)-piperidin-4-vl]-ben2vlamine
(A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(4-hydroxy-quinolin-3-yl)-methanone)
By proceeding in a similar manner to the method described in EXAMPLE 1, but using 4-hydroxy-
quinoline-3-carboxylic acid (prepared according to the procedure of K.J.Shah, and E.A.Coats, J. Med.
Chem., 1977, 20(8), pages 1001-1006) in place of 5-phenylethynyLpyridine-3-carboxylic acid, there
was prepared the title compound as a white amorphous solid, -H NMR[(CD3)2SO, 500 MHz]: 6 8.10
(m, 2H), 7.68 (m, 1H), 7.59 (m, 1H), 7.36 (m, 3H), 7.22 (m, 2H), 4.65 (br m, 1H), 4.00 (m, 2H), 3.80 (brm, lH),3.35(brm, - 3.10 (br m, - 3.00 (brm, - 1.90-1.75 (br m, 4H). MS(EI):
362(M--+H).
EXAMPLE 34 3-[l-(6-Phenvl-quinoline-3-carbonvlVpiperidin-4-yl]-benzvlamine di-hydrochloride (A.K.A. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-(6-phenyl-quinoIin-3-yl)-methanone di-hydrochloride)

By proceeding in a similar manner to the mettiod described in EXAMPLE 1, but using 6-phenyl-quinoline-3-carboxylic acid [prepared according to the procedure of J.Biwersi et al., Am. J. Physiol., 1992, 262(1, Pt. 1), C243-C250] in place of 5-phenyIethynyl-pyridine-3-carboxylic acid, there was
prepared the title compound as a white amorphous solid. -H NMR[(CD3)2SO, 500 MHz]: 6 9.00 (s,
- 8.59 (s, - 8.41 (s, - 8.10 (m, 2H), 7.85 (m, 2H), 7.58 (m, 2H), 7.45 (m, 2H), 7.34 (m, 3H), 4.75 (brm, - 4.00 (m, 2H), 3.80 (brm, - 3.35 (br m, - 3.00 (br m, - 2.90 (br m, 1 H),
1.90-1,75 (br m, 4H). MS(El): 422(M--+H).
EXAMPLE 35 4-(3-Aminomethvl-phenvn-l-(5-phenethvl-pvridine-3-carbonylVpiperidine-4-carbQnitrilc
A. 3-Cyanobenzvlcvanide
To a solution of 9,8g (200 mmole) of sodium cyanide and 1.61g (5 mmole) of tetrabutylammonium bromide in 50 ml of water was added a solution of 19..61g (100 mmole) of a-bromo-m-tolunitrile in 150 ml of dichloromethane. The mixture was stirred at room temperature for 24 hours. To this mixture was added 6.2 ml (100 mmole) of iodomethane. The mixture was stirred at room temperature for 3 hours. The layers were separated and the organic layer was dried over magnesium sulfate and was filtered. The filtrate was evaporated and the residue was triturated with petroleum ether and the insoluble material was collected to give 14.5g ofa white solid, mp-66-9-C; 100% yield: -H-NMR(300 MHz, CDCI3) 6 (TMS) 3.80-3.90(s, 2H), 7.49-7.72(m, 4H).
B. N-fgrr-Butoxvcarbonvl-bis(2-chloroethynamine
To a mixture of I7.85g (100 mmole) of bis(2-chloroethyl)amine hydrochloride and 24.0g (110 mmole) of di-/erNbutyl dicarbonate in 100 ml of dichloromethane was added a solution of 15.3 ml (110 mmole) of trietylamine in 50 ml of dichloromethane dropwise over 30 minutes. The mixture was stirred at room temperature for 24 hours and was poured into water. The organic layer was dried over magnesium sulfate and was filtered. The filtrate was evaporated to give 24g of an oil, 100% yield: -H-NMR (300 MHz, CDCL3) 5 (TMS) 1.37-1.56 (m, 9H), 3.50-3.62 (m, 8H); MS (ESI) m/e 242 (M+H)-
C. 4-(3-Cyanophenvl)-l-tert-butoxvcarbonvl-piperidine-4-carbonitrile
To a solution of 2.8g (19.7 mmole) of 3-cyanobenzylnitrile and 4.77g (19.7 mmole) ofN-tert-butylcarbonyl-bis(2-chloroethyl)amine in 100 ml of anhydrous DMF was added 2.36g (59.1 mmole) of 60% sodium hydride in portions over 10 minutes. The mixture was stirred at room temperature for 3 days and was poured into water and was extracted with ether. The ether layer was dried over magnesium sulfate and was filtered. The filtrate was evaporated and the residue was purified by flash

chromatography using 4:1 hexane:ethyl acetate to give the product as a white solid: -H-NMR (300 MHz, CDCI3) 6 (TMS) 1.45(s, 9H), 1.85-2.0(m, 2H), 2.0-2.28(m, 2H), 3.05-3,3O(m, 2H), 4.12-4.4(m, 2H), 7.53-7.80(ni, 4H).
D. 4-(3-Aminomethyl-phenylVl--tert-butoxvcarbonvl-piperidine-4-carbonitrile
To a mixture of 0.31g (1 mmole) of 4-(3-cyanophenyl)-l-tert-butoxycarbonyl-piperidine-4-carbonitrile in 30 ml of absolute ethanol was added O.OSm! (1 mmole) of cone, hydrochloric acid followed by 30mg of 5% Pd/C. The mixture was agitated in a Parr shaker for 3 hours at 30 lbs. of pressure of hydrogen. The mixture was filtered through celite and the filtrate was evaporated. The residue was treated with ether and was stirred for 30 minutes and was filtered. The filter cake was treated with aqueous sodium carbonate and was extracted with dichloromethane to give 0.2g of product: -H-NMR (300 MHz, CDCI3) 5(TMS) 138-1.60(m, 9H), 1.88-2.18(m, 4H), 3.05-3.30(m, 4H), 3.79-4.0(m, 2H), 7.22-7.85(m, 4H); MS (ESI) m/e 316 (M+H)-.
E. 4-(3-Benzyloxvcarbonylaminomethyl-phenyl)-l-tert-butoxycarbonYl-piperidine-4-carbonitrile
To a solution of 0.2g of 4-(3-Aminomethyl-phenyl)-l-tert-butoxycarbonyl-piperidine-4-carbonitrile in 15 ml of dichloromethane was added a few drops of triethylamine followed by a few drops of benzyl chloroformate. The mixture was stirred for 1 hour at room temperature and was poured into aqueous sodium carbonate and was extracted with dichloromethane. The organic layer was dried over magnesium sulfate and was filtered. The filtrate was evaporated and the residue was used directly in the next step without further purification : -H-NMR (300 MHz, CDCL3) 6 (TMS) 1,39-1.52 (m, 9H), 1.80-2.16(m, 4H), 3.G8-3.42(m, 4H), 4.19-4.50(m, 2H), 5.08-5.13(d, 2H), 7.28-7.79(m, 9H); MS (ESI) m/e 450 (M+H)-
F. 4-(3-Benzvloxycarbonylaminomethyl-phenyl)-piperidine-4-carbonitrile
The residue from the previous step was dissolved in dichloromethane containing 1 ml of trifiuoroacetic acid and the solution was stirred at room temperature for 45 minutes. The solution was poured into aqueous sodium carbonate and was extracted with dichloromethane. The organic layer was dried and evaporated and the residue was purified by flash chromatography using 7:3 hexane:ethyl acetate to give the product: -H-NMR (300 MHz, CDCL3) 6 (TMS) 1.80-2.18(m, 4H), 3.07-3.35(m, 4H), 4.28-4.50(m, 2H), 5.09-5.13(d, 2H), 7.10-7.77(m, 9H); MS (ESI) m/e 349 (M+H)-
G. 4-(3-Benzyloxvcarbonvlaminomethvl-phenvn-l-(5-phenethvl-pvridine-3-carbonvl)--piperidine-4-
carbonitrile
To a solution of 0,]5g (0.33 mmole) of 4-(3-benzyloxycarbonylaminomethyl-phenyl)-piperidine-4-carbonitrile in 20 ml of acetonitrile was added 0.038g (0.33 mmole) of N-ethylmopholine followed by

0.11 g (0.33 mmole) of TBTU. To this solution was added 0,075g (0,33 mmole) of 5-phenethylpyridine-3-carboxylic acid in portions over 10 minutes. The mixture was stirred for 2 hours. The solution was concentrated and the residue was purified by flash chromatography using 95:5 dichloromethane: methanol to provide 0.2g of product: -H-NMR (300 MHz, CDCL3) 8 (TMS) 1.79-2.20 (m, 4HX 2.70-2.82 (m, 4H), 2.90-3.07 (m, 2H), 3.15-3.70 (m, 2H), 4.35-4,40 (d, 2H), 5.07-5.25 (d, 2H), 7.10-7.50 (m, 15H), 8.42-8.58 (m, 2H); MS (ESI) m/e 559 (M+H)-.
H. 4-(3-Aminomethyl-phenylVl-(5-phenethyl-pyridine-3-Carbonyl)-piperidine-4-carbonitrile To a solution of 0.15g of 4-(3-benzyloxycarbonylaminomethyl-phenyI)-l-(5-phenethyl-pyridine-3-carbonyl)-piperidine-4-carbonitrile in 5 ml of glacial acetic acid was added 1 ml of 30% HBr in acetic acid. The solution was stirred at room temperature for 2 hours. The solution was poured into a saturated sodium carbonate solution and was extracted with dichloromethane. The organic layer was dried over magnesium sulfate and was filtered and evaporated. The residue was purified by Rainin HPLC using 10-100% (acetonitrile-0.1% aqueous TFA) to yield 16 mg of product isolated as the trifiuoroacetic acid salt:-H-NMR (300 MHz, DMSO-d-) 5 (TMS); 1.95-2.30 (m, 4H), 2.45-2.62(m, 2H), 2.88-3.12(m, 4H), 3.70-4.20 (m, 2H), 7.12-7.38(m, 4H), 7.45-7.82(m, 6H), 8.50-8.65(m, 2H); MS (ESI) m/e 425 (M+H)-.
EXAMPLE 36 [4-(3-Aminomethylphenynpiperidin-l-yl]-(3,4-dichlorQphenynmethanone trifiuoroacetate TFP resin (125mg of 1.25mmol/g resin, with 100% loading of acid, 156mmol, prepared according to the procedure described by J.M.Salvino et, al. in International Patent Application Publication No. WO 99/67228) was swollen in dichloromethane (2.5mL) for 15 minutes then treated with a solution of 4-(3-aminomethylphenyl)piperidine (40mg, lOOmmol) in dichloromethane (2.5mL). The mixture was sealed in the reaction vessel then left shaking for 8 hours. The resin was filtered, then washed with dichloromethane (2mL) [TLC (5% MeOH / EtOAc) showed single product spot (no baseline amine)] and then treated with trifluoroacetic acid (0.5mL). After shaking for 2 hours TLC showed no residual intermediate and the reaction mixture was evaporated. The residue [ 97% purity by HPLC: Ry = 7.32
minutes; 10 micron C18 reverse phase column (4.6mm x 10cm) eluting with 10-100% acetonitrile and
water containing 0.1%trifluoroacetic acid] was dissolved in water (50mL) and the solution was
lyophilized to give the title compound as an amorphous solid. -H NMR [(CD3)280]: 6 8.15 (br s, 3H),
7.72-7.69 (m, 2H), 7.40 (dd, - 7.36-7.25 (m, 4H), 4.66-4.51 (m, - 4.05-3.96 (m, 2H), 3.69-3.48 (m, - 3.30-3.11 (m, - 2.91-2.73 (m, 2H), 1.90-1.54 (m, 4H). MS(Ion spray): 363 and
365(M++1).
EXAMPLE 37

l-[4-(3-Arninornethvl-phenvn-piperidin-l-vl1-l-(2-phenoxv-phenvlVmethanone trifluoroacetate By proceeding in a similar manner to the method described in EXAMPLE 36, but using the 2-phenoxybenzoic acid derived TFP resin in place of the 3,4-dichlorobenzoic acid TFP resin, there was
prepared the title compound as a white amorphous solid. -H NMR [(CD3)280]: 5 8.11 (br s, 3H,
NH3-); 7.43-7.04 (m, lOH); 7.02-6.85 (m, 3H); 4.65-4.52 (m, H); 4.05-3.90 (m, 2H); 3.62-3.49 (m, H);
3-21-3.05 (m, H); 2.86-2.66 (m, 2H); 1.87-1.30 (m, 4H). MS(lon spray): 587 (M++1).
EXAMPLE 38 1-11 -[4-(3-Aminomethvl-phenvn-piperidin-l -vl]-methanoyl)-3-methvlsulfanvl-6.7-dihvdro-5H-benzorc1thiQphen-4-one trifluoroacetate
2-(lH-Benzotriazol-l-yl)-LL3,3-tetramethyluronium tetrafluoroborate (TBTU) (120mg, 0.38mmol) was added to a room temperature solution of 3-methylsulfanyl-4-oxo-4,5,6,74etrahydro-benzo[c]thiophene-l-carboxylic acid (88mg, 0.36mmol) and diisopropylethylamine (140mg, 1 .OSmmol) in dimethylformamide (2mL), under nitrogen. The reaction mixture was stirred for 10 minutes at room temperature before adding a solution of 4-[3-(N,N-di-tert-butoxycarbonyIaminomethyl)phenyl]piperidine (140mg, 0.36mmol) and diisopropylethylamine (140mg, 1 .OSmmol) in dimethylformamide (2mL). The reaction mixture was stirred at room temperature for 16 hours, concentrated to dryness in vacuo, and subjected to dry flash column chromatography on silica with 50:50, dichloromethaneiethyl acetate. l-{l-[4-(3-(N,N-di-tert-butoxycarbonylaminomethyl)phenyl)-piperidin-l-yl]-methanoyl}-3-methyIsulfanyl-6,7-dihydro-5H-benzo[c]thiophen-4-one was isolated as a colorless oil (177mg). The intermediate was dissolved in dichloromethane (20mL), cooled at 0°C, and treated with trifluoroacetic acid (2mL). The reaction mixture was stirred at room temperature under nitrogen for 2 hours, and concentrated to dryness in vacuo. The residue was dissolved in 20% acetonitrile/water [containing 0.1% trifluoroacetic acid] (9mL) and purified by preparative reverse-phase HPLC (C-18, 10 micron reverse-phase column), eluting with 10% to 100% acetonitrile / water (containing 0.1% trifluoroacetic acid). The product fractions were combined and the acetonitrile removed in vacuo. The aqueous residue was frozen and
lyophilized to give the title compound as an amorphous white solid (122mg, 64%). -H NMR [(CD3)2SO]: 5 8.16 (br s, 3H, NH3-); 7.41-7.24 (m, 4H); 4.21 (br d, 2H); 4.03 (q, 2H); 3.18-3.02 (m,
2H); 2.91-2.72 (m,3H); 2.59 (s,3H); 2.53-2.41 (m, 2H); 1.98-1.90 (m, 2H); 1.90-1.79 (m, 2H); 1.68-
1.50 (m, 2H). MS(lon spray): 415 (M++1).
EXAMPLE 39 l-[4-(3-Aminomethyl-phenvn-piperidin-l-vl1-l-(6-chloro-benzQ[b]thiophen-2-vl-)-methanone trifluoroacetate

By proceeding in a similar manner to the method described in EXAMPLE 38, but using 6-chiorobenzo[b]thiophene-2-carboxylic acid (prepared according to the procedure described in International Patent Application No. WO 0107436) in place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid, there was prepared the title compound as an
amorphous white solid. -H NMR [(003)280]: 5 8.17 (d, H); 8.14 (br s, 3H, NHs-); 7.91 (d, H); 7.73
(s, H); 7.45 (dd, H); 7.37 (s, H); 7.35-7.24 (m, 3H); 4.42 (br s, 2H); 4.00 (q, 2H); 3.12 (br s, 2H); 2.93-
2.79 (m, H); 1.89-1.77 (m, 2H); 1.70-1.55 (m, 2H). MS(Ion spray): 385 and 387 (M++1).
EXAMPLE 40 Nr4-(3-Aminomethvl-phenvl)-piperidin-l-vi1-l-(5-chloro-lH-indQl-2-vlVmethanone trifluoroacetate By proceeding in a similar manner to the method described in EXAMPLE 38, but using 5-chloro-lH-indole-2-carboxylic acid in place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-
carboxylic acid, there was prepared the title compound as an amorphous white solid. -H NMR [(CD3)2SO]: 5 11.78 (s, H); 8.14 (br s, 3H, NH-; 7,63 (s, H); 7.43-7.22 (m, 5H); 7.16 (dd, H); 6.76
(s, H); 4.55 (br d, 2H); 4,00 (q, 2H); 3.14 (br s, 2H); 2.94-2.80 (m, H); 1.90-1.79 (m, 2H); 1.73-1.54
(m, 2H); MS(lon spray): 368 and 370 (M++1).
EXAMPLE 41 l-r4-(3-Aminomethvl-phenvn-piperidin-l-vl1-l-(8-chloro-4H-K5-dithia-cvclopenta[a1naphthalen-2-vlVmethanone trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 8-chloro-4H-l,5-dithiacyclopenta[a]naphthalene-2-carboxylic acid in place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid, there was prepared the title compound as an
amorphous white solid. -H NMR [(003)280]: 8 8.14 (br s, 3H, NH3-); 7.52 (d, H); 7.44-7.23 (m, 7H);
4.45 (s, 2H); 4.43 (br d, 2H); 4.00 (q, 2H); 3.12 (br s, 2H); 2.95-2.80 (m, H); 1.90-1.78 (m, 2H); 1.72-
1.56 (m, 2H). MS(lon spray): 453 and 455 (M++1).
EXAMPLE 42 l-[4-(3-Aminomethvl-phenyn-piperidin-l-vn-l-(2-.4--difluoro-4-hvdroxy-biphenvl-3-yl)-methanone
trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using diflunisal in
place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid, there was
prepared the title compound as an amorphous white solid. -H NMR [(003)280]: 5 10.15 (s, H, OH);
8.15 (br s, 3H, NH,-); 7.56-7.46 (m, H); 7.40-7.22 (m, 7H); 7.13 (td, H); 6.97 (d, H); 4.64 (br s, H);

3.98 (q, 2H); 3.51 (br s, H); 3,10 (br s, H); 2.88-2.71 (m, H); 1.90-1.46 (m, 4H). MS(Ion spray): 423 and 424(M++l).
EXAMPLE 43 l-r4-(3-Aminomethvl-phenvlVpiperidin-l-v]1-l-n-methvlsulfanvl-6,7-dihvdro-benzo[c1thiophen-l-vl)-methanone trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 3-methylsulfanyl-6,7-dihydro-benzo[c]thiophene-l-carboxylic acid in place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-Carboxylic acid, there was prepared the title compound as an
amorphous white solid, -H NMR [CDCI3]: 6 8.13 (br s, 3H, NHs-); 7.38-7.30 (m, H); 7.27-7.18 (m,
3H); 6.68 (d, H); 6.11-6.04 (m, H); 4.52-4.25 (br m, 2H); 4.01-3.93 (br m, 2H); 3.40-3.38 (m, H); 3.12-2.97 (m, H); 2.90-2.75 (m, H); 2.75 (t, 2H); 2.43 (s, 3H); 2.37-2.28 (m, 2H); 1.97-1.81 (m, 2H); 1.89-
1.60 (m, 2H). MS(Ion spray): 400 (M++1).
EXAMPLE 44 l-|l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yn-methanovl|-6,6-dimethvl-3-methylsulfanyl-6,7-dihvdro-5H-benzo[c]thiophen-4-one trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 6,6-dimethyl-3-methylsulfanyU4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid in place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid, there was prepared the
title compound as an amorphous white solid. -H NMR [(€03)280]: 5 8.16 (br s, 3H, NH3*); 7.40-7.34
(m, 2H); 7.32-7.26 (m, 2H); 4.20 (br d, 2H); 4.01 (br s, 2H); 3.20-3.06 (m, 2H); 2.93-2.80 (m, H); 2.67 (s, 2H); 2,60 (s, 3H); 2,38 (3, 2H); 1.89-1.78 (m, 2H); 1.67-1.50 (m, 2H); 0.98 (s, 6H). MS(lon spray):
444(M++1).
EXAMPLE 45 l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl1-l-(6-bromo-pvridin-3-vn-methanone bistrifluoroacetate
A. 6-Bromonicotinic acid hydrochloride
/?-Butyllithium (8.0 mL of 2.5M in hexanes, 20 mmol) was added dropwise to a stirring solution of 2,5-dibromopyridine (4.74 g, 20 mmol) in THF (100 mL) at -100 °C, under nitrogen. The reaction mixture was left at this temperature for 30 minutes before bubbling anhydrous carbon dioxide gas through the reaction mixture (for 20 minutes), and leaving to warm to-20 °C. Quenched with IN HCI (20 mL) and brine (20 mL), and extracted into ethyl acetate, dried over magnesium sulfate, concentrated to dryness. 6-Bromonicotinic acid hydrochloride was isolated as a pale yellow powder

(3.8 g, 16mmol). *H NMR [CDCI3+CD3OD]: 6 8.86 (d, - 8.07 (dd, - 7.52(d, IH). MS(Ion spray): 202 and 204 (M--+I).
B. l-[4-(3-Arninomethvl-phenv!)-piperidin-l-vl]-l-(-6-brorno-pvridin-3-vlVrnethanone
bistrifluoroacctate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 6-
bromonicotinic acid hydrochloride in place of 3-methylsulfanyI-4-oxo-4,5,6,7-tetrahydro-
benzo[c]thiophene-I-carboxylic acid, there was prepared the title compound as an amorphous white
solid. 1H NMR [CD3OD]: 6 8.48 (d, H); 7.89 (dd, H); 7.82 (d, H); 7.48-7,30 (m, 4H); 4.90-4.81 (m,
H); 4.15 (s, 2H); 3.84 (br d, H); 3.46-3.36 (m, H); 3.11-2.91 (m, 2H); 2.13-1.68 (m, 4H). MS(Ion
spray): 374 and 376 (M++1).
EXAMPLE 46 6-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-vl]-methanovl}-2,3-dihvdro-thiazolor3,2-a1pvrimidin-5-one
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 5-0X0-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid in place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid, there was prepared the title compound as an
amorphous white solid. -H NMR [CD3OD]: 5 7.97 (s, H); 7.44-7.29 (m, 4H); 4.76 (br d, H); 4.59-4.51
(m, 2H); 4.07 (s, 2H); 3.83 (br d, H); 3.69-3.57 (m, 2H); 3.41-3.21 (m, H); 3.02-2.85 (m, 2H); 2.05-
1.67 (m, 4H). MS(Ion spray): 371 (M++1).
EXAMPLE 47 l-[4-(3-Aminomethvl-phenvn-piperidin-l-vn-l-(3-chloro-phenvn-methanonetrifluoroacetate By proceeding in a similar manner to the method described in EXAMPLE 38, but using 3-chlorobenzoic acid in place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-
carboxylic acid, there was prepared the title compound as an amorphous white solid. - H NMR [(CD3)2SO]: 8 8.14 (br s, 3H, NH3-); 7.57-7.43 (m, 3H); 7.40-7.22 (m, 5H); 4.70-4.56 (m, H); 4.01 (q,
2H); 3.64-3.56 (m, H); 3.23-3.10 (m, H); 2.91-2.79 (m, 2H); 1.92-1.52 (m, 4H). MS(lon spray): 329
and 331 (M++1).
EXAMPLE 48 l-[4-(3,Aminomethvl-phenyn-piperidin-l-vn-l-(4-chloro-phenvl)-methanonetrifluoroacetate By proceeding in a similar manner to the method described in EXAMPLE 38, but using 4-chlorobenzoic acid in place of 3-methylsulfanyl-4-oxO-4,5,6,7-tetrahydro-benzo[c]thiophene-l-

carboxylic acid, there was prepared the title compound as an amorphous white solid. -H NMR [(CD3)2SO]: 5 8.15 (br s, 3H, NH3-); 7.53 (d, 2H); 7.44 (d, 2H); 7.40-7.23 (m, 4H); 4,64-4.56 (m, H);
4.02 (q, 2H); 3.72-3.58 (m, H); 3.24-3.10 (m, H); 2.95-2.89 (m, 2H); 1.90-1.50 (m, 4H). MS(Ion
spray): 329 and 331 (M--+l).
EXAMPLE 49 l-[4-(3-Aminomethvl-phenvlVpiperidin-l-vlM-{3-[5-(2-chloro-phenvn-ri,3,4]oxadiazol-2-vl]-phenyl j-methanone trifluoroacetate
A. 3-f5-(2-Chlorophenvn-[K3,41oxadiazol-2-yl1-benzoic acid methyl ester
3-(2H-Tetrazol-5-yl)-benzoic acid methyl ester (204mg, Immol) (prepared by the method of Tanaka et al, J. Med. Chem., 1998, 41(13), 2406) and 2-chlorobenzoyl chloride (175mg, Immol) were combined in anisole (lOmL) at room temperature and 2,4,6-collidine (121mg, Immol) in anisole (ImL) was added. The reaction mixture was heated at 100°C for 1 hour followed by 120°C for 15 minutes, monitoring the evolution of gas by balloon [volume of gas evolved was measured by positive displacement of water, total = 22mL]. Cooled reaction mixture to room temperature, and concentrated to dryness in vacuo. The residue was subjected to flash column chromatography on silica with gradient dilution 5% to 40% ethyl acetate / heptane. 3-[5-(2-Chlorophenyl)-[l,3,4]oxadiazoI-2-yl]-benzoic acid
methyl ester was isolated as a colorless powder (229mg, 73%). -H NMR [CDCI3]: 5 8.79 (s, H); 8.36
(d, H); 8.25 (d, H); 8.14 (d, H); 7.72-7.57 (m, 2H); 7.57-7.41 (m, 2H); 4.00 (s, 3H). MS(Ion spray):
315and317(M++l).
B. l-[4-(3-Aminomethvl-phenyn-piperidin-l-yl1-l-l3-|-5-(2-chloro-phenyn-rK3,4]oxadiazol-2-yl1-
pheny 1} -methanone tri fl uoroacetate
IN Sodium hydroxide (2mL, 2mmol) was added to a solution of 3-[5-(2-chlorophenyl)-[ 1,3,4]oxadiazol-2-yl]-benzoic acid methyl ester (113mg, 0.36mmol) in methanol (5mL) and THF (2mL), and the reaction mixture stirred at room temperature for 2h, before neutralizing to pH 7 with IN hydrochloric acid. The solution was concentrated to dryness in vacuo and placed under high vacuum overnight. Crude material was used directly without purification [MS(Ion spray): 301 and 303
(M--+l); LC/ MS purity > 95%, only major impurity is sodium chloride]. 2-(lH-Benzotriazo[-l-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) (116mg, 0.36mmol) was added to a room temperature solution / suspension of crude 3-[5-(2-chlorophenyl)-[l,3,4]oxadiazol-2-yl]-benzoic acid and diisopropylethylamine (150mg, lJ4mmol) in dimethylformamide (2mL), under nitrogen. The reaction mixture was stirred for 10 minutes at room temperature before adding a solution of 4-[3-(N,N-di-tert-butoxycarbonylaminomethyl)phenyl]piperidine (78mg, 0.2mmol) and diisopropylethylamine

(150mg, l.Mmmol) in dimethylformamide (2mL). The reaction mixture was stirred at room temperature for 16 hours, concentrated to dryness in vacuo, and subjected to dry flash column chromatography on silica with 50:50, dichloromethane:ethyl acetate. l-{4-[3-(N,N-di-tert-butoxycarbonylaminomethyl)phenyl]-piperidin-l-yl}-l-{3-[5-(2-chloro-phenyl)-[l,3,4]oxadiazol-2-yi]-phenyl}-methanone was isolated as a colorless oil, which was dissolved in dichloromethane
(lOmL), cooled at 0°C, and treated with trifluoroacetic acid (ImL). The reaction mixture was stirred at room temperature under nitrogen for 2 hours, and concentrated to dryness in vacuo. The residue was dissolved in 20% acetonitrile/water [containing 0.1% trifluoroacetic acid] (9mL) and purified by preparative reverse-phase HPLC (C-18, 10 micron reverse-phase column), eluting with 20% to 60% acetonitrile / water (containing 0.1% trifluoroacetic acid). The product fractions were combined and concentrated to dryness in vacuo. The title compound was isolated as an amorphous white glass solid
(98mg, 83%). - H NMR [(€03)280]: 5 8.16 (br s, 3H, NHa-) overlapped with 8.22-8.16 (m, 2H) and
8.13 (s, H); 7.79-7.72 (m, 3H); 7.69 (td, H); 7.62 (td, H); 7.41 (s, H); 7.39-7.27 (m, 3H); 4.64 (br d, H); 4.03 (q, 2H); 3.79-3.63 (m, H); 3.28-3.20 (m, H); 3.03-2.80 (m, 2H); 1.96-1.57 (m, 4H). MS(lon
spray): 473 and 475 (M++1).
EXAMPLE 50 l-[4-(3-Aminomethvl-phenyl)-piperidin-l-yl]-l-[3-(5-pvridin-3-vl-[K3,41oxadiazol-2-v])-phenvl]-methanone bistrifluoroacetate
A. 3-(5-Pyridin-3-yl-[1,3.4]oxadiazol-2-yn-benzoic acid methyl ester
Prepared in a similar manner to the method described in EXAMPLE 49A, but using nicotinoyl chloride hydrochloride instead of 2-chlorobenzoyl chloride, 2mmol of 2,4,6-collidine, and heating at 110°C instead of 100°C. The residue was subjected to flash column chromatography on silica with ethyl acetate and 5% methanol / ethyl acetate. 3-(5-Pyridin-3-yl-[l,3,4]oxadiazol-2-yl)-benzoic acid
methyl ester was isolated as a colorless powder (84mg, 30%). -H MMR [CDCI3]: 5 9.40 (s, H); 8.84-
8.80 (m, H); 8.80-8.78 (m, H); 8.47 (dt, H); 8.38 (dt, H); 8.26 (dt, H); 7.67 (t, H); 7.52 (dd, H); 4.00 (s,
3H). MS(lon spray): 282 (M++1).
B. l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl1-l-[3-(5-pvridin-3-yl-[K3,4]oxadiazol-2-yn-phenyl]-
methanone bistrifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 49B, but using 3-(5-pyridin-3-yl-[l,3,4]oxadiazol-2-yl)-benzoic acid methyl ester in place of 3-[5-(2-chlorophenyl)-[l,3,4]oxadiazoI-2-yl]-benzoic acid methyl ester, there was prepared the title compound as an
amorphous white glass solid. -H NMR [(CD3)2SO]: 6 9.37 (br s, H); 8.86 (br s, H); 8.55 (d, H); 8.28-

8.23 (m, H); 8.20 (s, H); 8.16 (br s, 3H, NH3-); 7.79-7.65 (m, 3H); 7.41 (s, H); 7.39-7.26 (m, 3H); 4.63 (br d, H); 4.09-4.00 (m, 2H); 3,80-3.62 (m, H); 3.37-3.16 (m, H); 3.02-2.80 (m, 2H); 1.98-1.55 (m,
4H). MS(Ion spray): 441 (M++1).
EXAMPLE 51
l-{l-[4-(3-Aminorncthvl-phenvn-piperidin-l-vl]-methanoyl)-3-ethylsulfanyl-6,6-dimethy-dihvdro-5H-benzo[c]thiophen-4-one trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 49B, but using 3-ethylsulfanyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid methyl ester in place of 3-[5-(2-chlorophenyl)-[l,3,4]oxadiazol-2-yl]-benzoic acid methyl ester, there was prepared
the title compound as an amorphous white glass solid. -HNMR [(€03)280]: 5 8.16 (brs, 3H, NH3-);
7.40-7.33 (m, 2H); 7,32-7.26 (m, 2H); 4.30-4.00 (m, 4H); 3.21-3.10 (m, 2H); 3.06 (q, 2H); 2.92-2.80 (m, H); 2.66 (s, 2H); 2.38 (s, 2H); 1.90-1.78 (m, 2H); 1.68-1.50 (m, 2H); 0.98 (s, 6H). MS(Ion spray):
458(M-+--M).
EXAMPLE 52 l-{l-[4-(3-Aminomethvl-phenvlVpiperidin-l-vl]-methanoyl}-3-prQpvlsulfanvl-6,7-dihvdro-5H-benzo[c]thiophen-4-Qne trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 49B, but using 4-oxo-3-propylsulfanyl-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid ethyl ester in place of 3-[5-(2-chlorophenyl)-[l,3,4]oxadiazol-2-yl]-benzoic acid methyl ester, there was prepared the title compound
as an amorphous white glass solid. -H NMR [(€03)280]: 5 8.14 (br s, 3H, NH3-); 7.41-7.23 (m, 4H);
4.21 (br d, 2H); 4.08-3.99 (m, 2H); 3.39-2.99 (m, 4H); 2.94-2.71 (m, 3H); 2.54-2.49 (m, 2H); 2.02-
1.90 (m,2H); 1.90-1.70 (m, 4H); 1.70-1.51 (m, 2H); 1.03 (t, 3H). MS(lon spray): 443 (M++1).
EXAMPLE 53 l-{l-[4-(3-Aminomethyl-phenyn-piperidin-l-vl]-methanovl|-3-isopropvlsulfanvl-6.7-dihvdro-5H-ben2o[c]thiophen-4-one trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 49B, but using 3-isopropylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid ethyl ester in place of 3-[5-(2-chlorophenyl)-[l,3,4]oxadiazol-2-yl]-benzoic acid methyl ester, there was prepared the title
compound as an amorphous white glass solid. -H NMR [(003)280]: 5 8.14 (br s, 3H, NH3-); 7.43-
7.23 (m, 4H); 4.30-4.16 (m, 2H); 4.09-3.98 (m, 2H); 3.53 (septet, H); 3.22-3.03 (m, 2H); 2.93-2,72 (m, 3H); 2.54-2.47 (m, 2H); 2.02-1.86 (m, 4H); 1.70-1.51 (m, 2H); 1.42 (d, 6H). MS(lon spray): 443
(M++1).

EXAMPLE 54 3-{l-[4-(3-Aminomethvl-phenvlVpiperidin-I-vl1-methanovll-5,5-dirnethvl-7-oxo-4,5,6J-tetrahvdrQ-benzo[c1thiophene-l-carbonitrile trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 49B, but using 3-cyano-6,6-dimethyI-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid ethyl ester in place of 3-[5-(2-chiorophenyi)-[l,3,4]oxadiazol-2-yl]-benzoic acid methyl ester, there was prepared the title compound
as an amorphous white glass solid. -H NMR [(003)280]: 5 8.14 (br s, 3H, NHj-); 7.41-7.33 (m, 2H);
7.32-7.26 (m, 2H); 4.30-3.90 (br m, 2H); 4.04-3.98 (m, 2H); 3.30-3.01 (m, 2H); 2.93-2.80 (m, H); 2.71
(s, 2H); 2.54 (s, 2H); 1.89-1.76 (m, 2H); 1.73-1.51 (m, 2H); 1.01 (s, 6H). MS(lon spray): 423 (M++1).
EXAMPLE 55 3-{l-[4-(3-Aminomethyl-phenvl)-piperidin-l-vn-mcthanovl}-5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxvlic acid trifluoroacetate
The title compound was isolated as a by-product from the reaction carried out to synthesize 3-{ l-[4-(3-aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carbonitrile trifluoroacetate, in EXAMPLE 54. -H NMR [(CD3)280]: 6 9.70 (s,
H, OH); 8.11 (br s, 3H, NH3-); 7.42-7.26 (m, 4H); 4.28-3.96 (br m, 2H); 4.03-3.99 (m, 2H); 3.27-3.06 (m, 2H); 2.96-2.85 (m, H); 2.70 (s, 2H); 2.63 (s, 2H); 1.93-1.72 (m, 2H); 1.69-1.52 (m, 2H); 1.01 (s,
6H), MS(lon spray): 442 (M+-M).
EXAMPLE 56
3-|l-r4-(3-AminomethvLphenvl)-piperidin-l-vl]-methanoyl|-5,5-dimethvl-7-oxo-4,5,6,7-tetrahvdro-benzo[c]thiophene-l-carboxvlic acid methyl ester trifluoroacetate
The title compound was isolated as a by-product from the reaction carried out to synthesize 3-{ l-[4-(3-aminomethyl-phenyl)-piperidin-l-yl]-methanoyI}-5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene--carbonitrile trifluoroacetate, in EXAMPLE 54. -H NMR [(€03)280]: 5 8.16 (br
s, 3H, NH3-); 7.41-7.34 (m, 2H); 7.33-7.27 (m, 2H); 4.30-3.95 (br m, 2H); 4.06-4.00 (m, 2H); 3.84 (s, 3H); 3.25-3.04 (m,2H); 2.94-2.80 (m,H); 2.71 (s, 2H); 2.51 (s, 2H); 1.90-1.78 (m, 2H); 1.71-1.51 (m,
2H); 1.00 (s, 6H). MS(lon spray): 456 (M++1).
EXAMPLE 57 l-ll-[4-(3-Aminomethvl-phenvn-piperidin-l-vll-methanovll-3-methoxv-6,6-dimethvl-6J-dihvdro-5 H-benzoJc]thiophen-4-one.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 3-Methoxy-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-carboxylic acid, there was prepared the

title compound as an amorphous white solid. -H NMR [(CD3)2SO]: 5 8.22 (br s, 3H, NH3-), 7.54-7.27
(m, 4H), 4.29-4.22 (m, 2H), 4.14 (s, 3H), 4.13-4.02 (m, 2H) 3.26-3.08 (m, 2H), 3.04-2.86 (m, -2.71 (s, 2H), 2.37 (s, 2H), 2.02-1.84 (m, 2H) 1.79-1.54 (m, 2H), 1.04 (s, 6H). MS(Ion spray): 427.3
(M--fl).
EXAMPLE 58 l-[4-(3-AminQmethyl-phenvn-piperidin-l-vn-l-(4-pvrrol-l-vl-phenvi)-methanone-trifluorQacetate. By proceeding in a similar manner to the method described in EXAMPLE 38, but using 4-(l H-Pyrrol-I-yl) benzoic acid in place of 3-methylsuIfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-l-
carboxylic acid, there was prepared the title compound as an amorphous white solid. -H NMR [(CD3OD]: 8 7.62-7,51 (m, 4H), 7.41-7.22 (m, 6H), 6.32-6.28 (m, 2H), 4.85-4.66 (m, 2H), 4.08 (s,
2H), 4.03-3.88 (m, - 3.15-2.86 (m, 2H), 2.11-1.62 (m, 4H). MS(Ion spray): 360 (M++1).
EXAMPLE 59 l-[4-(3-Aminomethvl-phenvl)-piperidin-l-vl]-l-benzo[b1thiophen-2-vl-methanonc-trifluoroacetate. By proceeding in a similar manner to the method described in EXAMPLE 38, but using benzo(b)-thiophene-2-carboxylic acid in place of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-
1-carboxylic acid, there was prepared the title compound as an amorphous white solid. - H NMR [(CD3OD]: 6 7.98-7.81 (m, 2H), 7.62 (s, - 7.45-7.32 (m, 5H), 7.31-7.22 (m, - 4.80-4.40 (m,
2H), 4.10 (s, 2H), 3.28-3.05 (m, - 3.02-2.90 (m, 2H), 2.02-1.88 (m, 2H), 1.86-1.65 (m, 2H).
MS(Ion spray); 351 (M++1).
EXAMPLE 60 (EVl-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-3-(3-methoxv-phenvn-propenone-trifluoroacctate. By proceeding in a similar manner to the method described in EXAMPLE 38, but using 3-
methoxycinnamic acid, there was prepared the title compound as an amorphous white solid. *H NMR [(CD3OD]: 6 7.56 (d, - 7.45-7.25 (m, 5H), 7,23-7.13 (m, 3H), 6.98-6.90 (m, - 4.85-4.70 (m,
- 4.50-4.35 (m, - 4.08 (s, 2H), 3.83 (s, 3H), 3.40-3.32 (m, - 3.0K2.75 (m, 2H), 2.08-1.83 (m,
2H), 1.81-1.61 (m,2H).MS(Ion spray): 351 (M++1).
EXAMPLE 61 l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-l-(3-ethoxv-thiophen-2-vl)-methanone-trifluoroacetate. By proceeding in a similar manner to the method described in EXAMPLE 38, but using 3-ethoxythiophene-2-carboxylic acid, there was prepared the title compound as an amorphous white
solid. 1H NMR [(CD3OD]: 5 7.53 (d, - 7.46-7.22 (m, 4H), 6.94 (d, - 4.60-4.21 (br.m., 2H),

4.19 (q, 2H) 4.08 (s, 2H), 3.18-2.98 (m, - 2.96-2.85 (m, 2H), 2.0-1.86 (m, 2H), 1.84-1.65 (m, 2H), 1.37 (t, 3H). MS(lon spray): 345 (M++1).
EXAMPLE 62 l-[4-(3-Aminomethvl-phcnvn-piperidin-l-vl]-2-indA11-2-vl-ethanone-trifluoroacetate. By proceeding in a similar manner to the method described in EXAMPLE 38, but using 2-
indanylacetic acid, there was prepared the title compound as an amorphous white solid. -H NMR [(CD3OD]: 5 7.45-7.25 (m, 4H), 7.18-7.15 (m, 2H), 7.14-7.04 (m, 2H), 4.78-4.65 (m, - 4.18-4.11
(m, 1H), 4.08 (s, 2H), 3.28-3.08 (m, 2H), 2.95-2.76 (m, 2H), 2.74-2.58 (m, 6H), 2.0M .85 (m, 2H),
1.75-1.51 (m, 2H). MS(Ion spray): 349 (M++1).
EXAMPLE 63 l-[4-(3-Aminomethvl-phenvl)-piperidin-l-vl]-l-[5-(3-ChlQro-phenvl)-pvridin-3-vl1-methanone-ditrifluoroacetate.
A. 5-(3-chlorophenvn-nicotinic acid
A three neck flask was charged with 5-bromonicotinic acid (2 g, 9.90 mmol), 3-chlorophenylboronic acid (1.55 g, 9.90 mmol), a 0.4 M solution of sodiumcarbonate in water (37 mL, 14.8 mmol) and Acetonitrile (37 mL). The solution was degassed under vacuum and tetrakistriphenylphoshine Pd(0) (0.57 g, 0.495 mmol) was added and the reaction refluxed overnight under nitrogen. The reaction was cooled to room temperature and filtered through a celite pad. The filtrate was partially evaporated under reduced pressure and the remaining solution acidified to pH=2 with IN HCl. The resulting solid
was collected by filtration and dried under vacuum. -H NMR [(CD3)280]:-5 9.15-9.05 (m, 2H), 8.45
(s, 1H), 7-85 (s, 1H), 7.80-7.65 (m, 1H), 7.60-7.42 (m, 2H).
B. l-[4-(3-Aminomethvl-phenvn-piperidin-l-yn-l-r5-(3-chloro-phenvn-pvridin-3-yl1-methanone-
ditrifiuoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 5-(3-
chlorophenyO-nicotinic acid, there was prepared the title compound as an amorphous white solid. -H NMR [(CD3)2SO]:_8 8.99 (s, - 8.65 (s, - 8.18 (s, - 8.13 (br.s., 3H, NH--), 7.88 (s, 1H), 7.76
(d, - 7.58-7.45 (m, 2H), 7.40-7.20 (m, 4H), 4.80-4.58 (m, - 3,98 (q, 2H), 3.78-3.55 (m, -
3.33-3.18 (m, - 2.98-2.71 (m, 2H), 1.95-1.52 (m, 4H). MS(Ion spray): 406 (M++1).
EXAMPLE 64 l-[4-(3-Aminomethvl-phcnvn-piperidin-l-vl1-l-(5-chloro-benzo[b1thiophen-2-vl)-methanone-trifluoroacetate.

By proceeding in a similar manner to the method described in EXAMPLE 38, but using 5-chloro-benzo(b)thiophene-2-carboxylic acid, prepared as in WO 0107436, there was prepared the title
compound as an amorphous white solid. -HNMR [(CD3)2SO]:_5 8.08 (br.s., 3H, NH3+), 8.05 (d, -
8.01 (s, - 7,68 (s, - 7.47 (d, - 7.40-7.21 (m, 4H), 4.41 (br.s., 2H), 3.99, (q, 2H), 3.30-3.15
(m, 2H), 2.95-2.78 (m, - 1.90-1.75 (m, 2H), 1.73-1.52 (m, 2H), MS(Ion spray): 385 (M++1).
EXAMPLE 65 l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-2-(3,4-dichloro-phcnvl)-ethanone-trifluoroacetate. By proceeding in a similar manner to the method described in EXAMPLE 38, but using 3,4-
dichlorophenyl acetic acid, there was prepared the title compound as an amorphous white solid. -H NMR [(CD3)2SO]:_5 8.08 (br.s., 3H, NH3-), 7.56 (d, - 7.48 (s, - 7.38-7.15 (m, 5H), 4.58-4.45
(m, - 4.15-3.92 (m, 3H), 3.85-3.65 (m, 2H), 3.18-3.03 (m, - 2.85-2.55 (m, 2H), 1.80-1.65 (m,
2H), 1.55-1.32 (m, 2H). MS(Ion spray): 376 (M++1).
EXAMPLE 66 1 -[4-(3-Aminomethvl-phenvn-piperidin-1 -vl1-2-(5-chloro-pvridin-3-vloxv)-ethanQne-ditrifluoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using (5-chloro-pyridin-3-ylo\y)-acetic acid, prepared as in WO 0107436, there was prepared the title compound as an
amorphous white solid. -H NMR [(CD3)2SO]:_5 8.28-8.21 (m, 2H), 8.15 (br.s., 3H, NH3O, 7.58 (s,
- 7.40-7.20 (M, 4H), 5.01 (s, 2H), 4.52-4,38 (m, - 3.98 (q, 2H), 3.93-3.80 (m, - 3.22-3.05
(m, - 2.88-2.58 (m, 2H), 1.88-1.35 (m, 4H). MS(Ion spray): 360 (M+-1l).
EXAMPLE 67 l-[4-(3-Aminomethvl-phenyl)-piperidin-l-vn-2-(6-chloro-pvridin-2-yloxv)-ethanone-ditrifluoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using (6-chloro-pyridin-2-yloxy)-acetic acid, prepared as in WO 0107436, there was prepared the title compound as an
amorphous white solid. 1H NMR [(CD3)2SO]:_5 8.10 (br.s., 3H,NH3-), 7.81-7.71 (m, - 7.41-7.18
(m, 4H), 7.08 (d, - 6.88(d, - 5.15-4.92 (m, 2H), 4.50-4.31 (m, - 4,08-3.81 (m,3H),3.27-3.08 (m, - 2.92-2.76 (m, - 2.75-2.60 (m, - 1.90-1.58 (m, 2H), 1.57-1.35 (m, 2H). MS(Ion
spray): 360 (M--+l).
EXAMPLE 68

(EVl-[4-(3-Aminomethvl-phenvl)-piperidin-l-vl1-3-(5-chloro-thiophen-2-vl)-propenone-
trifluoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 3-(5-chloro-
thiophen-2-yl)-acrylic acid, prepared as in WO 0107436, there was prepared the title compound as an
amorphous white solid. -H NMR [(CD3)2SO]:_5 8.08 (br.s., 3H, NH3-), 7.56 (d, - 7.40-7.28 (m,
3H), 7.26-7.18(m,2H),7.12(d, lH),6.92(d, - 4.70-4.50 (m, - 4.41-4.21 (m, - 3.98 (q, 2H), 3.28-3.05 (m, - 2.90-2.63 (m, 2H), 1.91-1.72 (m, 2HX 1.65-1.35 (m, 2H).). MS(lon spray): 361
(M+-fl).
EXAMPLE 69
(E)-l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-3-(4-chloro-thiophen-2-vl)-propenone-
trifluoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 3-(4-chloro-
thiophen-2-yl)-acrylic acid, prepared as in WO 0107436, there was prepared the title compound as an
amorphous white solid. 1H NMR [(CD3)2SO]:_5 8.06 (br.s., 3H, NH3-), 7.65 (s, - 7.60-7.48 (m,
2H), 7.40-7.20 (m, 4H), 7.08 (d, - 4.70-4.51 (m, - 4.42-4.25 (m, - 4.05-3.93 (m, 2H), 3.28-
3.08 (m, - 2.90-2.63 (m,2H), 1.90-1.65 (m, 2H), 1.63-1.40 (m, 2H). MS(lon spray): 361 (M++1).
EXAMPLE 70 l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-l-(-4,5,6,7-tetrahvdro-benzo[c1thiophen-l-vl)-methanone-trifluoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 4,5,6,7-tetrahydro-benzo(c)thiophene-l-carboxylic acid, prepared as in JOC V62#6 1997 p. 1599, there was prepared the title compound as an amorphous white solid.
-H NMR [(CD3)2SO]:_6 8.13 (br.s., 3H, NH3-), 7.40-7.33 (m, 2H), 7.31-7.25 (m, 2H), 7.20 (s, -
4.35-4.15 (m, 2H), 4.03 (q, 2H), 3.17-2.98 (m, 2H), 2.95-2.78 (m, - 2.73-2.58 (m, 4H), 1.90-1.78
(m, 2H), 1.75-1.63 (m, 4H), 1.61-1.42 (m, 2H). MS(Ion spray): 355 (M--+l),
EXAMPLE 71 l-[4-(3-AminQmethyl-phenvl)-piperidin-l-vl1-l-(5-chloro-4-methoxv-thiophen-3-vl)-methanone-trifluoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 2-chloro-3-methoxy-thiophene-4-Carboxylic acid, there was prepared the title compound as an amorphous white
solid. 1H NMR [(003)2 S0]: 5 8.13 (br.s., 3H, NH3-), 7.57 (s, - 7.40-7.22 (m, 4H), 4.70-4.58 (m,

- 4.05 (q, 2H), 3.85 (s, 3H), 3.75-3.60 (m, - 3,25 (m, - 2.95-2.78 (m, 2H), 1.93-1.70 (m, 2H), 1.68-1.45 (m, 2H). MS(Ion spray): 365 (M--+l).
EXAMPLE 72 l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-l-(lH-indol-3-vl)-methanone-trifluoroacctate By proceeding in a similar manner to the method described in EXAMPLE 38, but using Indole-3-
carboxylic acid, there was prepared the title compound as an amorphous white solid, -H NMR [(CD3)2SO]:_5 8.13 (br.s., 3H, NH--), 7.78-7.63 (m, 2H), 7.52-7.20 (m, 6H), 7.20-7.03 (m, 2H), 4.57-
4.38 (m, 2H), 4.03 (q, 2H), 3.17-3.02 (m, 2H), 2.95-2.75 (m, - 1.90-1.78 (m, 2H), 1.75-1.57 (m,
2H). MS(Ion spray): 334 (M++1).
EXAMPLE 73 l-[4-(3-Aminomethvl-phenvl)-4-hydroxv-piperidin-l-vl]-l-(5-phenethyl-pvridin-3-vl)-methanone-ditrifluoroacetate.
A. 4-(3-Cvano-phenyl)-4-hvdroxy-piperidine-l-carboxylic acid--tert--butyl ester.
A solution of 3-Bromobenzonitrile (0.48 g, 2.64 mmol) in THF (20 mL) was stirred under nitrogen at -78-C. To this was added dropwise a solution of 2.0M nBuLi in hexanes (1.38 mL, 2.72 mmol). The solution was allowed to warm to -15°C over 1.5 hours. The solution was recooled to -78-C and a solution of N-Boc-4-piperidone (0.53 g, 2.64 mmol) in THF (5 mL) was added dropwise. The reaction mixture was allowed to warm to -1 O-C and stirred at this temperature for three hours. The reaction was quenched with Yi saturated ammonium chloride solution (30 mL) and stirred 15 minutes. The THF was removed by evaporation and the residue extracted with methylene chloride (3 X 50 mL). The organic extracts were combined, dried over sodium sulfate, evaporated to give an orange oil which was purified by flash chromatography 3:5:2 methylene chloride: heptane: ethyl acetate to give the title
compound (0.30 g) as a clear oil. - H NMR [(CDCl3]:_6 7.82 (s, lH),7.72(d, lH),7.58(d, 1H),7.55-
7.42 (m, - 4.20-3.95 (m,2H), 3.35-3.10 (m,2H), 2.08-1.83 (m,2H), 1.80-1.66 (m, 2H), 1.51 (s,
9H).
B. 4-r3-(Benzvloxvcarbonvlamino-methvlVphenvn-4-hvdroxv-piperidine-l-carboxylic acid-tert-
butyl ester.
A solution of 4-(3-Cyano-phenyl)-4-hydroxy-piperidine-l-carboxylic acid-r-r/-butyl ester (0.30 g, 0.99 mmol) in 7N ammonia/methanol (25 mL) and 5%Rhodium on alumina (0.15 g) was hydrogenated overnight on a Parr apparatus (45 psi). The reaction was filtered through celite, evaporated, and azeotroped with MeOH:toluene 1:1 (2 X 30 mL) to give 4-(3-Aminomethyl-phenyl)-4-hydroxy-

piperidine-1-carboxylic acid-tert-butyl ester as a foam. This compound was used directly in the next step.
To a stirred mixture of 4-(3-Aminomethyl-phenyl)-4-hydroxy-piperidine-l-carboxylic acid-tert-butyl ester (0.30 g, 0.99 mmol), methylene chloride (10 mL) and water (10 mL) was added potassium carbonate (0.28 g, 2.02 mmol) followed by benzylchloroformate (0.34 g, 2.02 mmol). The reaction stirred overnight at room temperature. The reaction was extracted with methylene chloride (3 X 30 mL). The organic extracts were combined, dried over sodium sulfate and evaporated to give a tan oil. Purification by flash chromatography 40% Ethyl acetate: Heptane yielded 4-[3-(Benzyloxycarbonylamino-methyl)-phenyl]-4-hydroxy-piperidine-l-carboxylic acid--tert-butyl ester (0.40 g). -H NMR [(CDC13]L5 7.45-7.18 (m, 9H), 5.15 (s, 2H), 5.08 (br.s., IH, NH), 4.40 (d, 2H), 4.15-3.93 (m, 2H), 3.35-3.15 (m, 2H), 2.08-1.90 (m, 2H), 1.75-1.62 (m, 2H), 1.50 (s, 9H).
C.l-f4-(3-Aminomethyl-phenyl)-4-hydroxv-piperidin-l-vl]-l-(5-phenethyl-pvridin-3-vn-methanone-
ditrifluoroacetate.
To a stirred solution of 4-[3-(BenzyIoxycarbonylamino-methyl)-phenyl]-4-hydroxy-piperidine-l-
carboxylic -c\d-tert-buty\ ester (0.38 g, 0.86 mmol) and methylene chloride (15 mL) at O°C was added
trifluoroacetic acid (5 mL). The reaction was allowed to warm to room temperature, stirred one hour
and was evaporated to dryness to give [3-(4-(Hydroxy-piperidin-4-yl)-benzyl]-carbamic acid benzyl
ester which was used directly in the next step.
To a stirred solution of 5-phenethyl-pyridin-3-carboxylic acid (0.027 g, 0.1 mmol) and DMF (10 mL) was added diisopropylethyl amine (0.014 g, 0.11 mmol) followed by TBTU (0.0353 g, 0.11 mmol). This stirred for five minutes before adding a solution of [3-(4-(Hydroxy-piperidin-4-yl)-benzyl]-carbamic acid benzyl ester (0.045 g, 0.1 mmol), DMF (2 mL) and Diisopropylethylamine (0.039 g, 0.3 mmol). The reaction stirred overnight at room temperature. The solvent was removed by evaporation and the remaining residue partitioned between ethylacetate (50 mL) and saturated sodium bicarbonate (10 mL). The organic phase was separated, washed again with saturated sodium bicarbonate (10 mL) and dried over magnesium sulfate. Evaporation followed by purification by flash chromatography (100% ethylacetate) gave (3-{4-Hydroxy-l-[-l-(5-phenethyl-pyridin-3-yl)-methanoyl]-piperidin-4-yl}-benzyl)-carbamic acid benzyl ester (0.030 g) as a clear oil. Hydrogenation with Methanol (10 mL), Acetic acid (1 mL) and a catalytic amount of 10% Palladium on Carbon overnight followed by filtration through celite gave the crude product which was purified by HPLC as in Example 38 to give
the title compound as an amorphous solid (9.1 mg). -H NMR [(CD3)2SO]:_8 8.58-8.42 (m, 2H), 8.15
(br.s., 3H, NH3-), 7.73 (s, - 7.63-7.51 (m, 2H), 7.40 (t, - 7.38-7.25 (m, - 7.23-7.10 (m, 5H), 4.58-4.38 (m, - 4.03 (q, 2H), 3.60-3.10 (m, 3H), 3.05-2.86 (m, 4H), 2.06-1.80 (m, 2H), 1.78-1.63
(m, - 1.62-1.42 (m, IH). MS(lon spray): 416 (M++1).

EXAMPLE 74 l-[4-(3-Aminomcthvl-phenvn-piperidin-l-vl1-l-(l-methvl-lH-indol-3-vl)-methanone-tnfluQroa By proceeding in a similar manner to the method described in EXAMPLE 38, but using 1-MethyM H-
indole-3-carboxylic acid, there was prepared the title compound as an amorphous white solid. -H NMR [CDCl3]:_6 8.63 (br.s., 3H, NH3-), 7.60 (d, - 7.51 (s, - 7.41-7.18 (m, 5H), 7,15-7.05 (m,
2H), 4.55-4.35 (m, 2H), 4.01 (br.s., 2H), 3.78 (s, 3H) 3.18-2.95 (m, 2H), 2.80-2.61 (m, 1H), 1.85-1.45
(m, 4H). MS(Ion spray); 348 (M--+l).
EXAMPLE 75 1-(3-{l-[4-(3-Aminomethvl-phenvl)-piperidin-l-yn-methanovl}-indol-l-yl)-ethanone-trifluoroacetate. By proceeding in a similar manner to the method described in EXAMPLE 38, but using 1-Acetyl-lH-
indole-3-carboxylic acid, there was prepared the title compound as an amorphous white solid. - H NMR [(CD3)2SO]:_5 8.39 (d, - 8.21 (br.s., 3H, NH3-), 8.13 (s, lH),7.70(d, - 7.68-7.25 (m,
6H), 4.40 (br.s., 2H), 4.15-4.02 (m, 2H), 3.15-3.03 (m, 2H), 2.99-2.80 (m, - 2.71 (s, 3H), 1.95-1.76
(m, 2H), 1.74-1.55 (m, 2H). MS(lon spray): 376 (M++1).
EXAMPLE 76 l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl1-l-(5-methoxv-l-methvl-lH-indol-3-vl)-methanQne-trifluoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 5-Melhoxy-l-methyl-1 H-indole-3-carboxylic acid, prepared as in WO 9522524, there was prepared the title compound as an amorphous white solid.
-H NMR [(CD3)2SO]:_6 8.13 (br.s., 3H, NH3-), 7,71 (s, - 7.51-7.23 (m, 5H), 7.20 (s, - 6.83
(dd, - 4.53-4.40 (m, 2H), 4.13-3.95 (m, 2H), 3.80 (s, 3H), 3.76 (s, 3H), 3.18-3.01 (m, 2H), 2.95-
2.75 (m, 1H), 1.95-1.76 (m, 2H), 1.75-1.52 (m, 2H). MS(Ion spray): 378 (M++1).
EXAMPLE 77 l-[4-(3-Aminomethvl-phenvl)-piperidin-l-yl]-l-[3-(2-trifluoromethyl-phenvlethvnyl)-phenvl1-methanone trifluoroacetate
A. 4-(3-[A-,A--bis-(tert-butoxvcarbonyl)aminomethyn-phenvl)-piperidine
As an alternative route, a one-pot cross coupling process was applied to the preparation of the title
compound. A solution of 3-[A-,A--bis-(tert-butoxycarbonyl)aminomethyl]-bromobenzene (EXAMPLE

1 A) (7.7 g, 20 mmol) in anhydrous DMF (60 ml) was treated with potassium acetate (5.9 g, 60 mmol), bis(pinacolato)diboron (5 g, 20 mmol), and [l,r-bis-(diphenylphosphino) ferroceno]-dichloropalladium (n)-dichloromethane complex (0.49 g, 0.60 mmol). This mixture was stirred at 80°C under an atmosphere of nitrogen for 4 hours, then benzyl l,2,3,6-tetrahydro-4-(trifluoromethylsulphonyloxy)-pyridine-l-carboxylate (EXAMPLE IB) (9.2 g, crude, B. l-[4-f3-AminomethvLphenvl)-Piperidin-l-vl]-l-r3-(2-trifluoromethyl-phenvlethynvn-phenvl]-methanone trifluoroacetate
By proceeding in a similar manner to the coupling method described in EXAMPLE 5B, but using 2-iodobenzotrifluoride, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white soIid.-H NMR [CD3OD]: 5 7.80-7.30 (m, 12H), 4.81 (br, 1H),
4.10 (s, 2H), 3.87 (br - 3.30 (br, - 2.97 (m, 2H), 2.05-1.60 (br, 4H). MS (Ion spray): 463 (M+1).
EXAMPLE 78 l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-l-[3-(2-methvl-phenvlethvnyl)-phenvl1-methanone trifluoroacetate
By proceeding in a similar manner to the coupling method described in EXAMPLE 5b, but using 2-iodotoluene, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 5 7.66-7.16 (m, 12H), 4.81 (br, -
4.11 (s, 2H), 3.87 (br - 3.30 (br, - 2.97 (m, 2H), 2.51 (s, 3H), 2.05-1.60 (br, 4H). MS (Ion
spray): 409 (M+1).
EXAMPLE 79 l-r4-(3-Aminomethvl-phenvn-piperidin-l-vl]-l-[3-(4-chloro-phenvlethvnyl-phenvl]-methanone trifluoroacetate
By proceeding in a similar manner to the coupling method described in EXAMPLE 5b, but using 1-chloro-4-iodobenzene, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 5 7.68-7.28 (m, 12H), 4.82 (br, - 4.11 (s, 2H), 3.87 (br - 3.30 (br, - 2.97 (m, 2H), 2.05-1.60 (br, 4H). MS (Ion spray): 429 and 431 (M+1).

EXAMPLE 80 144-(3-Aminomethyl-phenyl)-piperidin-l-vl1-l-[3-(2-chlorQ-phenvlethvnvl)-phenyl]-met-trifluoroacetatg
By proceeding in a similar manner to the coupling method described in EXAMPLE 5b, but using 1 -chloro-2-iodoben2ene, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 5 7.69-7.28 (m, 12H), 4.82 (br, - 4.11 (s, 2H), 3.87 (br - 3.30 (br, - 2.97 (m, 2H), 2.05-L60 (br, 4H). MS (Ion spray): 429 and 431 (M+1).
EXAMPLE 81 l-[4-(3-AminomethvLphenvn-piperidin-l-vl1-l-[3-(2-fluorQ-phenvlethvnvn-phenvl1-methanone trifluoroacetate
By proceeding in a similar manner to the coupling method described in EXAMPLE 5b, but using 1-fluoro-2-iodobenzene, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 5 7.69-7.16 (m, 12H), 4.80 (br, - 4.10 (s, 2H), 3.84 (br - 3.30 (br, - 2.96 (m, 2H), 2.05-1.60 (br, 4H). MS (Ion spray): 413 (M+1).
EXAMPLE 82 l-[4-(3-Aminomethvl-phenvl-)-piperidin-l-vl1-l-r3-(3-fluoro-phenvlethynyl)-phenvl]-methanone trifluoroacetate
By proceeding in a similar manner to the coupling method described in EXAMPLE 5b, but using 1-fluoro-3-iodobenzene, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 5 7.67-7.10 (m, 12H), 4.80 (br, 1H), 4.10 (s, 2H), 3.85 (br - 3.30 (br, - 2.95 (m, 2H), 2.05-1.60 (br, 4H). MS (Ion spray): 413 (M+1).
EXAMPLE 83 l-[4-(3-Aminomethvl-phenyl)-piperidin-l-vn-l-f3-(4-fluoro-phenvlethvnvn-phenvl1-methanone trifluoroacetate
By proceeding in a similar manner to the coupling method described in EXAMPLE 5b, but using 1-fluoro-4-iodobenzene, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. -1H NMR [CD3OD]: 6 7.64-7.10 (m, 12H), 4.80 (br, - 4.10 (s, 2H), 3.85 (br - 3.30 (br, - 2.97 (m, 2H), 2.05-1.60 (br, 4H). MS (Ion spray): 413 (M+1).

EXAMPLE 84 l-[4-(3-Aminomethvl-phenvlVpiperidin-l-vl]-l-l3-[2-(2-fluorO-phenvlVethvl]-phcnvll-methanon-trifluoroacetate
By proceeding in a similar manner to the reduction method described in EXAMPLE 9, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 8 7.43-6.96 (m, 12H), 4.78 (br, - 4.11 (s, 2H), 3.72 (br -3.18 (br, - 3.02-2.86 (m, 6H), 2,05-1.50 (br, 4H). MS (Ion spray): 417 (M+1).
EXAMPLE 85 l-f4-n-Aminomethvl-phenvl)-piperidin-l-vl]-l-l3-[2-f3-fluoro-phenvl)-ethvn-phenvl)-methanone trifluoroacetate
By proceeding in a similar manner to the reduction method described in EXAMPLE 9, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. 1H NMR [CD3OD]: S 7.43-6.80 (m, 12H), 4.78 (br, - 4.11 (s, 2H), 3.70 (br -3-18 (br, IH) 3.02-2.85 (m, 6H), 2.05-1.50 (br, 4H). MS (Ion spray): 417 (M+1).
EXAMPLE 86
l-[4-(3-Aminomethyl-phenvn-piperidin-l-yn-l-(3-r2-(4--fluoro-phenvn-ethvn-phenvl}-methanone
trifluoroacetate
By proceeding in a similar manner to the reduction method described in EXAMPLE 9, and the
deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous
off-white solid. -H NMR [CD3OD]: 5 7.43-6.88 (m, 12H), 4.78 (br, - 4.10 (s, 2H), 3.69 (br -
3.18 (br, - 3.00-2.85 (m, 6H) 2.05--].50 (br, 4H). MS (Ion spray): 417 (M+1).
EXAMPLE 87 ]-F4-(3-Aminomethvl-phenyl)-piperidin-l-vn-l-(3-[2-(6-amino-pvridin-3-vl)ethvnyl]-phenvl}-methanone tri-trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using (6-tert-butoxycarbonylamino-pyridin-3-yl)ethynyl-pyridine-3-carboxylic acid (prepared according to the method described in EXAMPLE 7), the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 6 8.82 (s, - 8,66 (s, - 8.17 (s, - 8.07 (s, - 8.02 (d, - 7.43-7.27 (m, 4H), 7.05 (d, - 4.81 (br, - 4.10 (s, 2H), 3.79 (br - 3.37 (br, - 2.97 (m, 2H), 2.05-1.70 (br, 4H). MS (Ion spray): 412 (M+l).

EXAMPLE 88 l-[4-(3-Aminomethyl-phenyl)piperidin-l-vl]-l-|3-[2-(6-amino-Pvriclin-3-vn-ethvl1-phenvl}-methanone tri-trifluoroacetate
By proceeding in a similar manner to the reduction method described in EXAMPLE 9, and the deprotection method described in EXAMPLE 38, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 5 8.60 (m, 2H), 7.94 (s, lH),7.89(d, - 7.61 (s, - 7.45-7.28 (m, 4H), 6.97 (d, - 4.80 (br, - 4,11 (s, 2H), 3.76 (br - 3.10-2.90 (m, 7H), 2.05-1.60 (br, 4H). MS (Ion spray): 416 (M+1).
EXAMPLE 89 l-[4-(3-Aminomcthvl-phenyl)-piperidin-l-vl]-l-(6-chloro-thienof3,2--1thiophen-2-Vl)-methanone trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 6-chloro-thieno[3,2-/7]thiophene-2-carboxylic acid, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 6 7.60 (s, - 7.47 (s, - 7.33-7.18 (m, 4H), 4.50 (br, 2H), 3.98 (s, 2H), 3.12 (br, 2H), 2.86 (m, - 1.85 (b, 2H), 1.67 (m, 2H). MS (Ion spray): 391 and 393 (M+1).
EXAMPLE 90 l-[4-(3-Aminomethyl-phenvl)-piperidin-l-vl]-l-(5-fluoro-thienQ[3,2-b)]thiophen-2-vn-methanone trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 5-fluoro-thieno[3,2--]thiophene-2-carboxylic acid, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 5 7.65 (s, - 7.44-7.17 (m, 4H), 7.03 (s, - 4.60 (br, 2H), 4.12 (s, 2H), 3.22 (br, 2H), 2.97 (m, - 1.97 (b, 2H), 1.78 (m, 2H), MS (Ion spray): 375 (M+1).
EXAMPLE 91 l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl1-l-(5-methvl-thienor3,2-fc1thiophen-2-vn-methanone trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 5-methyl-thieno[3,2-b]thiophene-2-carboxylic acid, the title compound was prepared as an amorphous off-white solid. -H NMR [CD3OD]: 6 7.60 (s, - 7.42-7.30 (m, 4H), 7.07 (s, - 4.63 (br, 2H), 4.11 (s, 2H), 3.21 (br, 2H), 2.97 (m, - 2.60 (s, 3H), 1.96 (b, 2H), 1.78 (m, 2H). MS (Ion spray); 371 (M+1).
EXAMPLE 92

l-r4-(3-Aminomethvl-phenvl)-piperidin-l-vl]-l-(5-chloro-thienor3.2-b]terthiophen-2-vn-rnethanone
trifluoroacetate
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 5-chloro-
thieno[3,2-Z)]thiophene-2-carboxylic acid, the title compound was prepared as an amorphous off-white
solid. -H NMR [CD3OD]: 6 7.63 (s, - 7.42-7.29 (m, 5H), 4.60 (br, 2H\ 4.11 (s, 2HX 3.12 (br, 2H),
2.97 (m, 1H), 1.97 (b, 2H), 1.78 (m, 2H). MS (Ion spray): 391
In a similar manner to the methods described above, the following compounds are prepared:
EXAMPLE 93 l-(4-[3-(l-AminQethvnphenvl]-piperidin-l-vl}-l-(5-phenvlethvl-pvridin-3-vn-methanone di-hydrochloride
A. |-l-(3-BrQmophenvnethvl]-carbamic acid tert-butyl ester
3-Bromoacetophenone oxime (23.4 mmol) was stirred in glacial acetic acid (150mL) at room temperature under nitrogen, and zinc dust (94mmol) added portionwise. The reaction mixture was stirred at room temperature for 24 hours, filtered off the solids and concentrated the filtrate to dryness. The residue was diluted with water, acidified to pH 5 with IN HCI, and washed with ethyl acetate. The aqueous was basified with sodium hydrogen carbonate, extracted into ethyl acetate, dried over magnesium sulfate, and concentrated to dryness. The residue was dissolved in dimethylformamide (30mL) and triethylamine (36.9mmol) added. To this solution was added, dropwise, a solution of di-tert-butyldicarbonate (32.4mmol) in DMF (lOmL). The reaction mixture was stirred at room temperature for 6 hours, and left standing for 24 hours before concentrating to dryness. The residue was partitioned between water and ethyl acetate, and the aqueous phase extracted with ethyl acetate. The combined organic phase was washed with brine, dried over magnesium sulfate, and concentrated to dryness. The residue was purified by column chromatography on silica gel with dichloromethane as eluent, to give [l-(3-bromophenvnethvl]-Carbamic acid tert-butvl ester as a pale yellow oil which
crystallized upon standing. MS(EI): 300 and 302 (M++H).
B. l-|443-n-Aminoethynphenyn-piperidin-l-vl}-l-(5-phenvlethvl-pvridino-yn-methanonedi-
hydrochloride
By proceeding in a manner similar to the method described in EXAMPLE I7D, but using [l-(3-bromophenyl)ethyl]-Carbamic acid tert-butyl ester in place of N-(tert-butoxycarbonyl)-3-bromo-4-fluorobenzylamine, there was prepared [l-(3-{l-[l-(3-phenethyl-phenyl>methanoyl]-l,2,3,6-tetrahydro-pyridin-4-yl}-phenyI)-ethyl]-carbamic acid tert-butyl ester. This material was subjected to the same conditions as described in EXAMPLE 2A, but using [l-(3-{l-[l-(3-phenethyl-phenyl)-methanoyl]-l,2,3,6-tetrahydro-pyridin-4-yl}-phenyl)-ethyl]-carbamic acid tert-butyl ester in place of 5-

phenylethynylpyridine-3-carboxylic acid. The crude product from this reaction was purified by column chromatography on silica gel, before being subjected to the same conditions as described in EXAMPLE ID, but using [l-(3-{l-[l-(3-phenethylphenyl)-methanoyl]-piperidin-4-yl}phenyl)ethyl]carbamic acid tert-butyl ester in place of 3-[l-(5-phenylethynylpyridine-3-carbo-yl)piperidi--4-yI]benzonitrile. l-{4-[3-(l-Aminoethyl)phenyl]-piperidin-l-yl}-l-(5-phenylethyl-pyridin-3-yl)-methanone di-hydrochloride was isolated as a pale yellow solid. MS(EI):
414(M++H).
EXAMPLE 94 l-[4-(5-Aminomethyl-3-hvdroxvphenvn-piperidin-l-vl]-l-(5-phenvlethvl-pyridin-3-vl-)-methanonedi-hvdrochloride
A. 3-Bromo-N,N-(bis-tert-butoxvcarbonvl)-5-(tert-butvldimethvlsilvloxv)benzvlamine
(3-Bromo-5-methyl-phenoxy)tert-butyldimethylsilane (3.32mmol) [prepared according to the
procedure of J. E. Baldwin et al, Tetrahedron, 1991, 47(29), 5603], N-bromosuccinimide (3.65mmol),
and benzoyl peroxide (0.332mmol) were dissolved in dichloromethane (lOmL) and the reaction
mixture irradiated for 4 hours. Diluted with dichloromethane and washed with water, dried over
magnesium sulfate and concentrated to dryness. The crude material was purified by column
chromatography on silica gel with 10% ethyl acetate / cyclohexane to give (3-bromo-5-bromomethyl-
phenoxy)-tert-butyldimethylsilane as a colorless oil. This material was subjected to the conditions
described in the first part of EXAMPLE lA, but using (3-bromo-5-bromomethyl-phenoxy)-tert-
butyldimethylsilane in place of 3-bromobenzylbromide, to give 3-bromo-N,N-(bis-tert-
butoxycarbonyl)-5-(tert-butyldimethylsilyloxy)benzylamine as a colorless oil. MS (EI) 516 and 518
(M++H).
B. l-(5-Phenylethynylpyridine-3-carbonyl)-4-(pinacolatoboronyl)-l,2,3,6-tetrahydropyridine
By proceeding in a manner similar to the method described in EXAMPLE 17B, but using 5-
phenylethynylpyridine-3-carboxylic acid in place of 5-phenethylpyridine-3-carboxylic acid , there was
prepared l-(5-phenylethynylpyridine-3-Carbonyl)-4-(pinacolatoboronyl)-l,2,3,6-tetrahydropyridine as
a pale yellow solid. MS (El) 415 (M--+H).
C. l-{4-[3-(N,N-bis-tert-Butoxycarbonynaminomethyl-5-hydroxyphenyl]-3,6-dihydro-2H-pvridin-l-
vl}-l-(5-phenylethynylpyridin-3-ynmethanone
By proceeding in a manner similar to the method described in EXAMPLE 17D, but using 3-bromo-N,N-(bis-tert-butoxycarbonyl)-5-(tert-butyldimethylsilyloxy)benzylamine in place of N-(tert-butoxycarbonyl)-3-bromO-4-fIuorobenzylamine and l-(5-phenyIethynylpyridine-3-carbonyl)-4-

(pinacolatoboronyl)-l,2,3,6-tetrahydropyridine in place of l-(5-phenylethylpyridine-3-carbonyl)-4-(pinacolatoboronyl)-l,2,3,6-tetrahydropyridine, there was prepared l-{4-[3-(N,N-bis-tert-Butoxycarbonyl)aminomethyl-5-hydroxyphenyl]-3,6-dihydro-2H-pyridin-l-yl}-I-(5-
phenylethynylpyridin-3-yl)methanone as a pale brown solid. MS (EI) 610 (M--+H). The tert-butyl-dimethylsilyl moiety had unexpectedly been removed during this procedure.
P. l-[4-(5-Aminomethvl-3-hvdroxvphenvn-piperidin-l-yl]-l-(5-phenvlethvl-pvridin-3-vl)-methanone di-hydrochloride
By proceeding in a manner similar to the method described in EXAMPLE 2A, but using l-{4-[3-(N,N-bis-tert-butoxycarbonyl)aminomethyl-5-hydroxyphenyl]-3,6-dihydro-2H-pyridin-l-yl}-l-(5-phenylethynylpyridin-3-yl)methanone in place of 5-phenylethynylpyridine-3-carboxylic acid, there was prepared l-{4-[3-(N,N-bis-tert-butoxycarbonyl)aminomethyl-5-hydroxy-phenyl]piperidin-l-yl}-l-(5-phenethylpyridin-3-yl)methanone. The crude product from this reaction was purified by column chromatography on silica gel, before being subjected to the same conditions as described in EXAMPLE ID, but using l-{4-[3-(N,N-bis-tert-butoxycarbonyl)aminomethyl-5-hydroxy-phenyl]piperidin-l-yl}-l-(5-phenethylpyridin-3-yl)methanone in place of 3-[l-(5-phenylethynylpyridine-3-carbonyl)piperidin-4-yl]benzonitrile. l-[4-(5-Aminomethyl-3-hydroxyphenyl)-piperidin-l-yl]-l-(5-phenylethyl-pyridin-3-yl)-methanone di-hydrochloride was
isolated as a pale yellow solid. MS(EI): 416 (M++H).
EXAMPLE 95 l-[4-(5-Aminomethvl-2-hvdroxvphenvn-piperidin-l-Vl1-l-(5-phenvlethvl-pyridin-3-vl)-methanone di-hydrochloride
A. 4-Benzyloxv-3-bromobenzvl carbamic acid tert-butyl ester
3-Bromo-4-flurobenzonitrile (3.00 g, 15 mmol), benzyl alcohol (1.71 ml, 16.5 mmol) and THF (40 ml) are combined and treated with 60 % sodium hydride in oil (0.66 g, 16.5 mmol). The reaction mixture is heated to reflux under nitrogen for 3 hours. Aqueous workup and chromatographic purification (cyclohexane:dichloromethane, 3:1) yields 4-benzyloxy-3-bromobenzonitrile as a white solid (3.88 g, 13.5 mmol). A portion of this material (2.64 g, 9.16 mmol) in THF (25 ml) is treated with a 1 M solution of borane in THF (18.3 ml, 18.3 mmol). After the exotherm subsides the reaction is refluxed a couple of days under nitrogen. The excess borane is destroyed by the addition of methanol and 4-benzyloxy-3-bromobenzylamine is precipitated as the hydrochloride salt (1.58 g, 4.8 mmol). This material is suspended in dichloromethane (30 ml) and treated successively with triethyl amine (1.68 ml, 12.02 mmol) and di-tert-butyl dicarbonate (1.26 g, 5.77 mmol). The reaction mixture is stirred under nitrogen four hours; aqueous workup and chromatographic purification (ethyl

acetate.-cyclohexane, 3:7) yields the title compound as a white solid (1.69 g, 4,3 mmol). MS(EI): 394(M+).
B. 4-Benzyloxv-3-ll-[l-(5-phenvlethvlDvridin-3-vnmethanovn-1,2,3,6-tetrahvdropvridin-4-vl>-
benzyl carbamic acid tert-butyl ester
l-(5-Phenylethylpyridineo-carbonyl)-4-(pinacolatoboronyl)-I,2,3,6-tetrahyropyridine (0.628 g, ],5 mmol) as prepared in EXAMPLE 17B, 4-benzyloxy-3-bromobenzyl carbamic acid tert-buiy\ ester (0.62 g, 1.58 mmol), dichlorobis(triphenylphosphine)paliadium (II) (0.074, 0.08 mmol), potassium carbonate (0.622 g, 4.5 mmol) and DMF (15 mL) are heated to 80 °C under nitrogen for 3 hours. The DMF is removed in vacuo, the residue is subjected to an aqueous workup and the organic residue is purified by chromatography to give a gray foam (0.45 g, 0.75 mmol).
C. 3-HvdrQxv-2-{l-[1-(5-Phenylethvlpvridin-3-yl)methanoyl]-piperidin-4-vl}-benzyl carbamic acid
tert-buXy\ ester
4-Ben2yloxy-3-{I-[l-(5-pheny!ethyIpyridin-3-yl)methanoyl]-l,2,3,6-tetrahydropyridin-4-yl}-benzyl carbamic acid tert-buty\ ester (0.34 g , 0.56 mmol) is hydrogenolyzed with hydrogen gas and 10% P/C
to give the title compound as a white foam (0.27 g, 0.52 mmol). MS(EI): 515(-1-*-).
D. l-[4-(5-Aminomethyl-2-hydroxyphenyn-piperidin-l-vl1-l-(5-phenylethyl-pyridin-3-yl)-methanone
di-hydrochloride
3-Hydroxy-2-{l-[l-(5-phenyiethylpyridin-3-yl)methanoy]]-piperidin-4-yl}-ben2yl carbamic acid tert-butyl ester (0.09 g, 0.175 mmol) is converted to the title compound (0.053 g, 0.11 mmol) by the
procedure described in EXAMPLE 5C. MS(EI): 416(M++H).
EXAMPLE 96 l-[4-(5-Aminomethvl-2-benzyloxyphenvn-3,6-dihydrO-2H-pyridin-l-yl1-l-(5-phenylethyl-pyridin-3-vD-methanone di-hydrochloride
4-Benzyloxy-3-{l-[l-(5-phenylethylpyridin-3-yl)methanoyl]-l,2,3,6-tetrahydropyridin-4-yl}-benzyl carbamic acid tert~huXy\ ester (0.11 g, 0.184 mmol) is converted to the title compound (0.080 g, 0.15
mmol) by the procedure described in EXAMPLE 5C, MS(EI): 504(M++H).
EXAMPLE 97 l-[4-(3-Aminomethylphenyn-piperidin-l-yl1-l-(4-phenylethvl-phenvl)-methanone hydrochloride A. 4-Phenylethynylbenzoic acid,
4-Phenylethynylbenzaldehylde (1.01 g, 4.85 mmol) is added to a suspension of silver oxide (0.56 g, 2.43 mmol) in water (15 mi) and sodium hydroxide (0.97 g, 24.3 mmol). The reaction mixture is

heated to 90 -C for 1.5 hours cooled and acidified. The aqueous mixture is extracted with ethyl acetate and the organic layer is concentrated. The resultant solid is partitioned between ether and 0.1 M sodium hydroxide solution. The aqueous layer is acidified and the precipitated title compound (0.55g, 2.5 mmol) is collected. M.P. 224-225 -C; MS(EI): 222(M-)
B. l-[4-(3-AminomethylphenvlVpiperidin-l-vl]-l-(4-phenvlethvl-phenvn-methanone hydrochloride By proceeding in similar manner to the method described in EXAMPLE IC but using 4-phenylethynyl benzoic acid, A-,A--bis-(r-r-butoxycarbonyl)-3-[l-(4-phenylethynyl-benzoyl)-piperidin-4-yl]-benzylamine was prepared. The title compound is subsequently prepared by applying in sequence the
methods described in EXAMPLE 9. MS(El): 399(M++H).
EXAMPLE 98 l-f4-(3-Aminomethvl-phenvn-piperidin-l-vl1-l-(3-r2-(2-hvdroxv-phenvn-ethvl]-phenvUMTiethanone hydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 10 but using N,N--i-~itert-butoxycarbonyl)-3-{ 1 -[3-(2-hydroxyphenyl)ethynyl-benzoyl]-piperidin-4-yl}-benzylamine, which was prepared in a similar manner to the method described in EXAMPLE 6a but using 2-iodophenol, there was prepared the title compound as a white amorphous solid. MS(El): 415 (M+H).
EXAMPLE 99 l-[4-(5-Aminomethvl-2-hvdroxvmethvlphenvn-3,6-dihvdro-2H-pyridin-l-vl]-l-(5-phenvlethyl-
Pvridin-3-vn-methanone
A. Acetic acid 4-(N,N-bis-tert-butoxvcarbonvnaminomethvl-2-bromobenzvl ester 2-Bromo-4-(bromomethyl)benzylbromide (2.91 mmol) [prepared according to the procedure of Bridger et al, J. Med. Chem. 1995, 38(2), 366] and di-tert-butyliminodicarboxylate (2.91mmol) were dissolved in tetrahydrofuran (lOmL), and sodium hydride (60% in mineral oil, 2,91 mmol) added at room temperature under argon. The reaction mixture was stirred at room temperature for 4 days, quenched with saturated aqueous ammonium chloride, extracted into ethyl acetate, washed with brine, dried over magnesium sulfate, and concentrated to dryness. The crude residue was purified by column chromatography on silica gel with cyclohexane:ethyl acetate = 9:1. 3-bromo-4-bromomethyl-(N,N-biS-tert-butoxycarbonyl)benzylamine was isolated as a white solid. A portion of 3-bromo-4-bromomethyl-(N,N-bis-tert-butoxycarbonyl)benzylamine (1.88mmol) was dissolved in acetonitrile (15mL), and to this was added potassium acetate (3.7mmol) and 18-crown-6 (0.095mmol). The reaction mixture was stirred at room temperature for 16 hours, concentrated to dryness, extracted into ethyl acetate, washed with brine, dried over magnesium sulfate, and concentrated to dryness. Purification was carried out by

column chromatography on silica gel with diethyl ether: cyclohexane =1:1. Acetic acid 4-(N,N-bis-tert-butoxycarbonyl)aminomethyl-2-bromobenzyl ester was isolated as a colorless solid. MS (EI) 458
and 460 (M++H).
B. l-{4-[5-(N,N-bis-tert-Butoxvcarbonvnaminomethvl-2-acetoxvmethvlphenvl1-3,6-dihvdrO-2H-
pvridin-l-vn-l-(5-phenethvlpvridin-3-vnmcthanone
By proceeding in a manner similar to the method described in EXAMPLE 17D, but using acetic acid 4-(N,N-bis-tert-butoxycarbonyl)aminomethyl-2-bromobenzyl ester in place of N-(tert-butoxycarbonyl)-3-bromo-4-fluorobenzylamine, there was prepared l-{4-[5-(N,N-bis-tert-butoxycarbonyl)aminomethyl-2-acetoxymethylphenyl]-3,6-dihydro-2H-pyridin-l-yl}-l-(5-
phenethylpyridin-3-yl)methanone. MS (EI) 670 (M--+H).
C. i-f4-(5-Aminomethvl-2-hvdroxvmethvlphenvn-3.6-dihvdro-2H-pvridin-l-vl1-l-(5-phcnvlethvl-
p vr i d i n-3 - VI Vmethanone
l-{4-[5-(N,N-bis-tert-Butoxycarbonyl)aminomethyl-2-acetoxymethylphenyl]-3,6-dihydro-2H-pyridin-l-yI}-l-(5-phenethylpyridin-3-yl)methanone (0.3mmol) was dissolved in methanol (lOmL) and cooled at 0*-Cwhilst adding potassium carbonate (O.lmmol). Left at room temperature for 16 hours, concentrated to dryness and used crude residue directly in the next step. By proceeding in a manner similar to the method described in EXAMPLE ID, but using l-{4-[5-(N,N-bis-tert-butoxycarbonyl)aminomethyl-2-hydroxymethylphenyl]-3,6-dihydro-2H-pyridin-l-yl}-l-(5-phenethy]pyridin-3-yl)methanone in place of 3-[l-(5-phenylethynylpyridine-3-carbonyl)piperidin-4-yljbenzonitrile, there was prepared l-[4-(5-aminomethyl-2-hydroxymethylphenyl)-3,6-dihydro-2H-
pyridin-l-yl]-l-(5-phenylethyl-pyridin-3-yl)-methanone as a pale yellow solid. MS(E!): 428 (M-+H).
EXAMPLE 100 l-[4-(5-Aminomethvl-thiophen-2-vl)-piperidin-l-vl1-(5-phenvlethvl-pyri_din-3-yl)-methanone di-hydrochloride
A. 2-[A->7V-Bis-(/gr-butoxycarbonvl-)amjnomethyl]-4-bromo-thiophene
By proceeding in a similar manner to the method described in EXAMPLE 1A but using 4-bromo-2-bromomethyl-thiophene, which was simply prepared from reduction of 4-bromo-thiophene-2-carbaldehyde and subsequent bromonation of the alcohol, there was prepared the title compound.
B. l-[4-(5-Aminomethvl-thiophen-2-yl-)-piperidin-l-vl]-(5-phenvlethvl-pvridin-3-vl)-methanone di-
hydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 93 but using 2-[N,N-h\s-(tert-butoxycarbonyl)aminomethyl]-4-bromo-thiophene, there was prepared the title compound as a white amorphous solid. MS(EI): 406(M+H).

EXAMPLE 101 [4-(5-Aminomethvl-pvridin-3-vlVpiperidin-I-vl]-l-(5-phenylethvl-pvridin-3-vn-mcthanone tri-hydrochloride
A. 3-Bromo-5-(N,N-bis-tert-butQxvcarbonvl)aminomethvlpvridine
3-BromO-5-hydroxymethylpyridine (16.1mmol) [prepared according to the procedure of Ashimori et al, Chem. Pharm. Bull. 1990, 38(9), 2446] and pyridine (32.3mmol) were dissolved in acetonitrile (32mL) and cooled to 0°C. Dibromotriphenylphosphorane (20.9mmol) added, and left reaction mixture to warm to room temperature in stoppered flask for 4 hours. The crude reaction mixture was purified by column chromatography directly on silica gel with diethyl etherxyclohexane =1:1. 3-Bromo-5-bromomethylpyridine was isolated as a pale brown solid. 3-Bromo-5-bromomethylpyridine (7.7mmol) and di-tert-butyiiminodicarboxylate (lOmmol) were dissolved in tetrahydrofuran (20mL), and sodium hydride (60% in mineral oil, lOmmol) added at room temperature under argon. The reaction mixture was stirred at room temperature for 16 hours, quenched with saturated aqueous ammonium chloride, extracted into ethyl acetate, washed with brine, dried over magnesium sulfate, and concentrated to dryness. The crude residue was purified by column chromatography on silica gel with cyclohexane:diethyl ether = 2:1. 3-bromo-5-(N,N-bis-tert-butoxycarbonyl)aminomethylpyridine was
isolated as a pale yellow solid. MS (EI) 387 and 389 (M++H).
B. [4-(5-Aminomethyl-pvridin-3-vl)-piperidin-l-yl1-l-(5-phenylethyl-pyridin-3-yl)-methanone tri-
hydrochloride
By proceeding in a manner similar to the method described in EXAMPLE 17D, but using 3-bromo-5-(N,N-bis-tert-butoxycarbonyl)aminomethylpyridine in place of N-(tert-butoxycarbonyl)-3-bromo-4-fluorobenzylamine and 1 -(5-pheny]ethynylpyridine-3-carbonyl)-4-(pinacolatoboronyl)-l ,2,3,6-tetrahydropyridine in place of l-(5-phenyiethylpyridine-3-carbonyl)-4-(pinacolatoboronyl)-l,2,3,6-tetrahydropyridine, there was prepared l-[5-(N,N-bis-tert-butoxycarbonyl)aminomethyl-3-,6--dihydro-2-H-[3,4-]bipyridinyl-r-yl]-l-(5-phenylethynylpyridin-3-yl)methanone. This material was subjected to the same conditions as described in EXAMPLE 2A, but using l-[5-(N,N-bis-tert-butoxycarbonyl)aminomethyl-3-,6--dihydro-2-H-[3,4-]bipyridinyl-r-yl]-l-(5-phenylethynyIpyridin-3-yl)methanone in place of 5-phenyIethynylpyridine-3-carboxylic acid. The crude product from this reaction was purified by column chromatography on silica gel, before being subjected to the same conditions as described in EXAMPLE ID, but using {4-[5-( N,N-bis-tert-
butoxycarbonyl)aminomethylpyridin-3-yl]-piperidin-l-yl}-l-(5-phenylethyl-pyridin-3-yl)-methanone in placeof 3-[l-(5-phenylethynylpyridine-3-carbonyl)piperidin-4-yl]benzonitrile. [4-(5-Aminomethyl-

pyridin-3-yI)-piperidin-l-yl]-l-(5-phenylethyl-pyridin-3-yl)-methanone tri-hydrochloride was isolated as a pale yellow solid. MS(EI): 401 (M++H).
EXAMPLE 102 l-[4-(3-Aminomethvl-phenvl)-piperidin-l-vn-l-(l-ethyl-lH-indol-3-vl)-methanone-trifluoroacetate.
A. l-Ethvl-lH-indole-3-carboxylic acid methyl ester.
A flask was charged with lH-indole-3-carboxylic acid methyl ester ( 2g, 11.41 mmol) and iodoethane (4.4g, 28.5 mmol) iti dry THF ( 25 mL). The mixture was stirred in a water bath and a 60% dispersion of sodium hydride (0.68g, 17.12 mmol) in mineral oil was added in portions over 5 minutes. The reaction stirred for 48 hours and was quenched by careful addition of water. The mixture was extracted with dichloromethane (2 X 100 mL), dried over sodium sulfate and evaporated under reduced pressure. The crude product was purified by silica flash chromatography (10% ethyl acetate/heptane) to give 1-
ethyl-lH-indole-3-carboxylic acid methyl ester (1.8g). -H NMR [CDClsJ-S 8.22-8.15 (m, - 7.87
(s, - 7.42-7.33 (m, - 7.31-7.25 (m, 2H), 4.22 (q, 2H), 3.92 (s, 3H), 1.52 (t, 3H).
B. l-Ethyl-lH-indole-3-carboxylic acid.
A solution of l-ethyl-lH-indole-3-carboxylic acid methyl ester ( 1.8g, 8.8 mmol) was stirred in a 1:1 mixture of THF:MeOH (40mL), and to this was added 2N NaOH (20 mL). The reaction was heated at reflux for 4 hours. The reaction mixture was partially evaporated to remove the THF, MeOH and the remaining material diluted with water ( 20 mL) and acidified to pH=2 with IN HCI. The mixture was extracted with dichloromethane (100 mL), dried over sodium sulfate and evaporated under reduced pressure to give the title compound as a white solid, which was used directly in the next step.
C. l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-l-fl-ethvl-lH-indol-3-yl)-methanone-
trifluoroacetate.
By proceeding in a similar manner to the method described in EXAMPLE 38, but using 1-ethyl-lH-
indole-3-carboxylic acid, there was prepared the title compound as an amorphous white solid, -H NMR [CD3OD]: 5 7.75-7.63 (m, 2H), 7.52 (d, - 7.43-7.36 (m, 3H), 7.35-7.15 (m, 3H), 4.63-4.51 (m, 2H), 4.30 (q, 2H), 4,11 (s, 2H), 3.30-3.13 (m, 2H), 3.03-2.85 (m, - 2.00-1.86 (m, 2H), 1.85-
1.68 (m, 2H), 1.49 (t, 3H). MS (ion spray): 362 (M++1).
A. 4-Hydroxy-5,6-dihydro-2H-pyridine-L3-dicarboxylic acid 1-benzvl ester 3-ethvl ester To a solution of ethyl 4-piperidone-3-carboxylate hydrochloride (5g, 24.05mmol) in THF (70mL) and water (35mL) at O-C, was added triethylamine (8.7mL, 62.5 mmol), followed by N-(benzyloxycarbonyloxy)succinimide (7.79g, 31.27mmol). The reaction mixture was stirred and

allowed to warm to room temperature. After 3 hours the reaction mixture was diluted with water (50mL) and ethyl acetate (lOOmL) added. The aqueous phase was extracted into ethyl acetate (2xl00mL). The organic phases were combined, washed with brine (50mL), dried (MgS04), and the solvent removed in vacuo. The crude product was purified by column chromatography on silica gel (eluent, ethyl acetate : pentane = 1:5) to give 4-hydroxy-5,6-dihydro-2H-pyridine-l,3-clicarboxylic acid 1-benzyl ester 3-ethyl ester as a colorless oil (7.26g, 94%). MS (EI) 305 (M-).
B. 4-Trifluoromethanesulfonvloxv-5,6-dihvdro-2H-pvridine-K3-dicarboxvlic acid 1-benzyl ester 3-
ethyl ester
4-Hydroxy-5,6-dihydro-2H-pyridine-l,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester (15.94g, 52.5mmol) was dissolved in anhydrous THF (150mL) under nitrogen and cooled at -78°C during the addition of sodium bis(trimethylsilyl)amide (IM in THF; 68mL, 68mmol) via cannula. After stirring for 30 minutes at this temperature a solution of N-phenyltrifluoromethanesulfonimide (22.42g, 62.8mmol) in THF (230mL) was added dropwise via cannula. The reaction mixture was stirred at this temperature for 10 minutes before warming to 0°C and stirring for 2 hours. After 48h the reaction mixture was quenched with water, extracted into DCM, dried (MgS04) and concentrated in vacuo. The crude product was purified by flash column chromatography on silica gel (eluent; ethyl acetate:pentane - 4:1) to give 4-trifluoromethanesulfonyloxy-5,6-dihydro-2H-pyridine-l ,3-dicarboxylic acid 1 -benzyl ester 3-ethyl ester as colorless oil (18.59g, 81%). This material decomposed to a deep red material upon standing so was stored under nitrogen at O-C in the dark. MS (EI) 437 (M-).
C. 4-(4,4,5.5-Tetramethvl-U3,2-dioxaborolA11-2-yl)-5,6-dihvdro-2H-pyridine-U-dicarboxvlic acid I-
benzyl ester 3-ethvl ester
4-Trifluoromethanesulfonyloxy-5,6-dihydro-2H-pyridine-l,3-dicarboxylic acid I-benzyl ester 3-ethyl ester (200mg, 0.458mmol) was dissolved in anhydrous dioxane (6mL), and added dropwise, via cannula, to a mixture of potassium acetate (135mg, 1.374mmol), l,r-bis(diphenylphosphino)ferrocene (8mg, 0.014mmol), [l,r-bis(diphenylphosphino)ferroceno]dichloropalladium-dichloromethane complex (lOmg, 0.014mmol), and bis-pinnacolato diborane (116mg, 0.458mmol), under nitrogen. The mixture was heated at 80°C overnight, cooled to room temperature and partitioned between DCM and water. The aqueous phase was extracted with DCM, and the organic phases combined and dried (MgS04). Th crude product was purified by flash column chromatography on silica gel (eluent; pentane:ethyl acetate - 5:1) to afford 4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolA11-2-yl)-5,6-dihydro-2H-pyridine-l,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester as a colorless oil (94mg, 50%). MS (El) 415 (M-).
D. 4-l3-r(N,N-Bis-tert-butQxvcarbonyl)aminomethyl1phenyl}-5.6-dihvdro-2H-pvridine-K3-
dicarboxylic acid 1-benzyl ester 3-ethyl ester

A solution of 3-[N,N-bis-(tert-butoxycarbonyl)aminomethyl]bromobenzene (3.5Ig, 9.1mmol) [prepared by the method in Example 1 A] and 4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolA11-2-yl)-5,6-dihydro-2H-pyridine-l,3-dicarboxylic acid l-benzyl ester 3-ethyl ester (3.6g, 8.67mmol) in DMF (120mL) were added, viacannula, to amixture of [1,1--
bis(diphenylphosphino)ferroceno]dichloropalladium-dichloromethane complex (425mg, 0.52mmol) and potassium carbonate (3.59g, 26mmo]) under nitrogen. The reaction mixture was heated at SO--C overnight, concentrated to dryness in vacuo, and the residue partitioned between DCM and water. The aqueous phase was extracted with DCM, the organic phases combined, washed with brine, and dried (MgS04). The crude material was purified by column chromatography on silica gel (eluent; pentane : ethyl acetate = 6:1) to give 4-{3-[(N,N-bis-tert-butoxycarbonyl)aminomethyl]phenyl}-5,6-dihydro-2H-pyridine-l,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester as a colorless oil (2.27g, 44%). MS (EI) 594 (M-.
E. (3S, 4S) and (3R,4R) 4-{3-[(N.N-Bis-tert-butoxvcarbonvnaminomethvl]phenvl}-piperidine-3-
carboxylic acid ethyl ester
Solid carbon dioxide (Ig) was added to a solution of 4-{3-[(N,N-bis-tert-
butoxycarbonyl)aminomethyl]phenyl}-5,6-dihydro-2H-pyridine-l ,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester (2,07g, 3.48mmol) in IMS (20mL). 10% palladium on carbon (200mg) was added and the reaction mixture stirred at room temperature, under an atmosphere of hydrogen, for 4 hours. The palladium on carbon was filtered off through celite to give a 1:1 mixture of (3S, 4S) and (3R,4R) 4-{3-[(N,N-Bis-tert-butoxycarbonyl)aminomethyl]phenyl}-piperidine-3-carboxylic acid ethyl ester as a pale grey/brown oil (1.35g, 84%), which was pure enough for use in the subsequent reaction. MS (EI) 462 (M-.
F. (3S.4S)and (3R,4R)-4-l3-[(Bis-tert-butoxycarbonvl)aminomethyl1phenvU-l-(5-phenethvlpvridine-
3-carbonyl)piperidine-3-carboxylic acid ethyl ester
By proceeding in a similar manner to the method described in EXAMPLE 2B, but using a 1:1 mixture of (3S, 4S) and (3R,4R) 4-{3-[(N,N-Bis4ert-butoxycarbonyl)aminomethyl]phenyl}-piperidine-3-carboxylic acid ethyl ester instead of 4-{3-[N,N-bis(tert-
butoxycarbonyl)aiTiinomethyl]phenyl}piperidine, there was prepared a 1:1 mixture of (3S,4S) and (3R,4R)-4-{3-[(Bis-tert-butoxycarbonyl)aminomethyl]phenyl}-l-(5-phenethylpyridine-3-carbonyl)piperidine-3-carboxylic acid ethyl ester as a colorless glassy solid (414mg, 0.62mmol). MS (EI) 671 (M-).
G. (3S.4S) and (3R, 4R)-4-(3-Aminomethyl-phenyl)-l-(5-phenethvl-pvridine-3-carbonvl)-piperidine-
3-carboxylic acid ethyl ester dihydrochloride

By proceeding in a similar manner to the method described in EXAMPLE ID, but using a 1:1 mixture of(3S,4S) and (3R,4R)-4-{3-[(Bis-tert-butoxycarbonyl)aminomethyl]phenyl}-l-(5-phenethylpyridine-3-Carbonyl)piperidine-3-carboxyIic acid ethyl ester instead of N,N-bis-(tert-butoxycarbonyl)-3-[l-(5-phenylethynylpyridine-3-carbonyI)piperidin-4-yl]benzylamine, there was prepared a 1:1 mixture of (3S,4S) and (3R, 4R)-4-(3-AminomethyI-phenyl)-l-(5-phenethyl-pyridine-3-carbonyl)-piperidine-3-carboxylic acid ethyl ester dihydrochloride as a white solid. MS (EI) 471 (M-).
EXAMPLE 104 (3R.4S) and (3S, 4RV4-(3-Aminomethvl-phenvn-l-(5-phenethvl-pvridine-3-carbonvn-piperidine-3-carboxylic acid ethyl ester dihydrochloride
A. (3R,4S) and (3S.4R)-4-{3-[(tert-ButoxvcarbonvnaminQmethvl]phenvll-l-(5-phenethvlpvridine-3-
carbonyn-piperidine-3-carbQxylic acid ethyl ester
Sodium hydride (lOmg, 60% in mineral oil, 0.25mmol) was added to ethanol (lOmL), and after the effervescence had subsided a 1:1 mixture of (3S,4S) and (3R,4R)-4-{3-[(bis-tert-butoxycarbonyl)aminomethyl]phenyl}-l-(5-phenethylpyridine-3-carbonyl)piperidine-3-carboxylic acid ethyl ester (lOOmg) was added at room temperature. After 1 hour the solvent was removed in vacuo, and the residue partitioned between DCM and water. The aqueous phase was extracted with DCM, the combined organic phase washed with brine and dried (MgS04). The crude material was purified by column chromatography on silica gel (eluent; DCM:MeOH = 10:1) to give a 1:1 mixture of (3R,4S) and(3S,4R)-4-{3-[(tert-butoxycarbonyl)aminomethyl]phenyl}-l-(5-phenethylpyridine-3-carbonyl)-piperidine-3-carboxylic acid ethyl ester as a pale yellow glassy solid (43mg, 51%). MS (EI) 571 (M-).
B. (3R,4S) and (3S, 4R)-4-(3-Aminomethyl-phenvl)-l-(5-phenethyl-pyridine-3-carbonvn-piperidine-
3-carboxylic acid ethyl ester dihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 1D, but using a 1:1 mixture of (3R,4S) and(3S,4R)-4-{3-[(tert-butoxycarbonyl)aminomethyl]phenyl}-l-(5-phenethylpyridine-3-carbonyl)-piperidine-3-carboxylic acid ethyl ester instead of N,N-bis-(tert-butoxycarbonyl)-3-[l-(5-phenylethynylpyridine-3-carbonyl)piperidin-4-yl]benzylamine, there was prepared a 1:1 mixture of (3R,4S) and (3S, 4R)-4-(3-aminomethyl-phenyl)-l-(5-phenethyl-pyridine-3-carbonyl)-piperidine-3-carboxylic acid ethyl ester dihydrochloride as a white solid. MS (El) 471 (M-).
EXAMPLE 105 l-[4-(3-Aminomethyl-phenyn-piperidin-l-yl]-l-[5-(4-bromo-2-f1uoro-benzylamino)-pyridin-3-yl1-methanone trihydrochloride

A. 5-rerr-Butoxycarbonvlamino-nicotinic acid
To a solution of diethyl 3,5-pyridinedicarboxylate [prepared according to the procedure of J. C. Speelman and R. M. Kellogg, J. Org. Chem., 1990, 55 (2), pages 647-653; 64.19 g, 0.248 mol] in ethanol (650 mL) were added KOH pellets (14.56 g, 0.260 mol). The reaction mixture was stirred overnight at ambient temperature. Evaporation of solvent afforded a white solid that was rinsed with dichloromethane, and then dissolved in water. The aqueous solution was extracted with ether, and then acidified to pH 3. The resultant white precipitate was collected by filtration and dried to afford pyridine-3,5-dicarboxyiic acid monomethyl ester (33.70 g), A portion of this material (10.00 g, 51.3 mmol) was dissolved in dry i-er-butanol (300 mL) and treated sequentially with triethylamine (7.85 mL, 56.4 mmol) and diphenyl phosphoryl azide (11.5 mL, 53.4 mmol). The mixture was refluxed for 90 minutes, and then stirred at ambient temperature overnight. Solvent was removed under reduced pressure and the residue was partitioned between water and dichloromethane. The layers were separated and the aqueous phase was extracted twice with dichloromethane. The combined organic phases were dried and concentrated. Chromatography on silica gel eluting with a mixture of pentane and ethyl acetate (3:1, v/v) gave S--f-rr-butoxycarbonylamino-nicotinic acid ethyl ester (4.79 g). This ester was dissolved in methanol (45 mL) and treated with 1 N NaOH (54 mL, 54 mmol). After stirring 2 hours, volatiles were evaporated under reduced pressure and the residue was treated with 1 N HCl until the resultant slurry reached pH 3. The precipitate was collected by filtration, washed with water,
and dried to afford 5-fg--butoxvcarbonvlamino-nicotinic acid (4.21 g): *H NMR (300 MHz, DMSO-d6)6 13.39 (brs, lH),9.82(s, - 8.78 (d, J=2.5 Hz, - 8.69 (d, J=1.9 Hz, - 8.45-8.50 (m, -
1.50 (s,9H); -3cNMR(75MHz,DMSO-d6)6 166.2, 152.7, 143.4, 143.2, 136.2, 126.3, 124.9,80.0, 27.9; MS (ESI) m/z 239 (M+H).
B. |5-[l-(4-(3-fiV,A--Bis-fer/-butoxvcarbonvl)aminomethvl]-phenvU-piperidin-l-vl)methanovl1-
pyridin-3-yUcarbamic acid tert-butvl ester
To aO °C solution of 4-{3-[A-,A--bis-(/er-butoxycarbonyl)aminomethyl]-phenyl}-piperidine (0.1545 g, 0.3956 mmol, EXAMPLE IB), 5--er-butoxycarbonylamino-nicotinic acid (0.0966 g, 0.4055 mmol), l-hydroxy-7-azabenzotria2ole (0.0290 g, 0.2131 mmol), and l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.1500 g, 0.7824 mmol) in dimethylformamide (5.0 mL) was added pyridine (0.065 mL, 0.8037 mmol). The reaction mixture was stirred 30 minutes at 0 --C, then allowed to warm to room temperature under inert atmosphere. After 16 hours at ambient temperature the reaction solution was diluted with ethyl acetate (30 mL), washed with saturated ammonium chloride (2 X 15 mL), saturated sodium bicarbonate (15 mL), and brine (15 mL). The organic phase was dried over magnesium sulfate, filtered, and evaporated to dryness. The residue was purified by silica gel chromatography eludng with a mixture of ethyl acetate and methylene chloride (1:1, v/v) to give {5-[l-

(4-{3-[A-.A--biS-(-gr/-butoxvcarbonvnaminomethvl1-phenvl|-pipcridin-l-vl)methanovl1-pyri vUcarbamic acid tert-butyl ester as a colorless oil (0.1812 g): TLC, 50:50-methylene chloride:ethyl
acetate, Rf- 0,20. -H NMR(300 MHz, CDCI3) 6 8.67 (d, J=2.6 Hz, - 8.34 (d, J-1.4 Hz, - 8.09
(s, - 7.93 (s, - 7.21-7.35 (m, - 7.08-7.18 (m, 3H), 4.81-4.93 (m, - 4.78 (s, 2H), 3.81-3.93 (brm, - 3.11-3.28 (brm, - 2.70-2.96 (m, 2H), 1.51 (s, 9H), 1.45(s, 18H), 1.40-2.02 (m partially
obscured, 4H); l-C NMR (75 MHz, CDCI3) 5 167.5, 152.6, 152.5, 144.8, 141.3, 141.0, 138.9, 135.7,
131.8, 128.5, 125.6, 125.3, 125.2, 124.1, 82.4, 81.0, 77.2, 49.3, 42.5, 28.1, 27.8; MS (CI) m/z 611
(M+H).
C. (4-Bromo-2-fluoro-benzvl)-(5-[l-(4-(3-[A-.jV-bis-fer-butoxycarbonvl-)aminomethvl1-phenvU-
piperidin-l-vlVmethanovn-pvridin-3-vll-Carbamic acid dimethvl-ethvl ester
To a solution of {5-[l-(4-{3-[7V-A--biS-(-er-butoxycarbonyl)aminomethyl]-phenyl}-piperidin-l-yl)methanoyl]-pyridin-3-yl}carbamic acid /er/-butyl ester (0.0745 g, 0.1220 mmol) in dimethylformamide (2.0 mL) was added sodium hydride (61% suspension in mineral oil, 0.0216 g, 0.5499 mmol). Deprotonation was allowed to occur over 3 minutes while stirring under inert atmosphere. 4-Bromo-2-fluorobenzyl bromide (0.1559 g,0.5819 mmol) was added to the anion solution. The mixture was stirred an additional 10 minutes, then quenched with water (5,0 mL). The reaction solution was extracted with ethyl acetate (15 mL), and the organic phase was washed with brine (2x10 mL), dried over magnesium sulfate, filtered, and evaporated to dryness. Purification of the residue on silica gel eluting first with ethyl acetate/methylene chloride/hexane (1:1:2, v/v/v) and then with ethyl acetate and methylene chloride (1:1, v/v) afforded (4-bromo-2-fluoro-benzyl)-l5-ri-(4-|3-IXA--bis-(rerf-butoxvcarbonyl)aminomethvl]-phenyl|-piperidin-l-ylVmethanoylTpyridin-3-yU-carbamic acid dimethyl-ethyl ester as a colorless oil (0.0917 g): TLC, 50:50-methylene chloride:ethyl
acetate, Rf= 0.59. -H NMR (300 MHz, CDCI3) 6 8.47-8.51 (m, 2H), 7.61 (br s, - 7.07-7.32 (m,
7H), 4.89 (s, 2H), 4.78 (s, 2H), 4.77-4.92 (m partially obscured, - 3.68-3.83 (br m, - 3.09-3.24
(br m, 1H), 2.70-2.97 (m, 2H), 1.45 (s, 18H), 1.44 (s, 9H), 1.30-2.04 (m partially obscured, 4H); - -C NMR(75MHz,CDCl3)6 167.0, 160.4 (d, 250.8), 154.0, 152.7, 148.5,144.9, 139.0, 138.7, 132.2,
131.9, 130.7, 129.7, 127.9 (d, 3.4), 125.8, 125.7, 125.3, 123.8(d, 14.5), 121.8 (d, 9.7), 119.3 (d, 24.8),
82.5, 82.2, 49.5, 46.9, 42.6, 32.8 (br), 28.4, 28.2, 28.0; --F NMR (282 MHz, CDCI3) S -114.9; MS
(CI) m/z 797 (M+H).
D. l-[4-(3-Aminomethvl-phenyn-piperidin-l-yl]-l-[5-(4-bromo-2-fluoro-benzvlaminoVpvridin-3-Vl]-
methanone trihydrochloride
(4-Bromo-2-fiuoro-benzyl)-{5-[l-(4-{3-[A-,A--bis-(--r/-butoxycarbonyl)aminomethyl]-phenyl}-piperidin-l-yl)-methanoyl]-pyridin-3-yl}-carbamic acid dimethyl-ethyl ester (0.0806 g, 0.1010 mmol)

was treated with 4 M HCl in 1,4-dioxane (2.0 mL, 8.0 mmol) and stirred at ambient temperature. After 25 minutes the reaction mixture was diluted with isopropyl alcohol (0.5 mL) and stirring was continued for an additional 2.5 hours. Dripping the reaction solution into ether (40 mL) with vigorous stirring afforded a white precipitate which was collected by filtration, washed with fresh ether (3.0 mL), and dried to afford l-r4-(3-aminomethvl-phenvn-piperidin-l-vl1-l-r5-(4-bromo-2-fluoro-
benzvlamino)-pvridin-3-vl]-methanonetrihvdrochloride (0.0563 g): *H NMR (300 MHz, DMS0-d6)
5 8.39 (br s, 2H), 8.16 (d, J=2.7 Hz, - 8.08 (s, - 7.16-7.70 (m, 8H), 4.49-4.64 (br m, - 4,46 (s, 2H), 4.05-4.30 (m, - 4.00 (AB q, J=5.7 Hz, 2H), 3.01-3.25 (m, - 2.77-2.95 (m, 2H), 1.75-
1.92 (m, - 1,45-1.75 (br m, 3H); l-pNMR (282 MHz, DMSO-d6) 5 -114.1; MS (ESI) m/z497
(M+H).
EXAMPLE 106 l-[4-(3-Aminomethvl-phenvlVpiperidin-l-yl]-l-(5-benzvlamino-pvridin-3-v])-methanone trihvdrochloride
A. Benzvl-l5-[-l-(4-l3-[yV.7\--bis-(tert-butQxvcarbonvl)aminomethvll-phenvl}-piperidin-l-vn-
methanoyl]-pvridin-3-vlj-carbamic acid dimethyl-ethyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using benzyl bromide in place of 4-bromo-2-fluorobenzyl bromide, there was prepared benzyl-l5-[ 1 -(4-f 3-[iV.A--bis-(tert-butoxvcarbonyl)aminomethvl]-phenvl|-piperidin-l-ylVmethanoyn-pyridin-3-vl|-carbamic acid
dimethyl-ethyl ester as a yellow oil. TLC, 50:50-methylene chIoride:ethyl acetate, Rf = 0.48. *H NMR
(300 MHz, CDCI3) 5 8.52 (d, J=2.2 Hz, - 8.46 (d, J=1.2 Hz, - 7,56 (s, - 7.04-7.38 (m, 9H),
4.89 (s, 2H), 4.78 (s, 2H), 4.75-4.90 (m partially obscured, - 3.63-3.88 (br m, - 3.00-3.19 (br m,
- 2.68-2.90 (m,2H), 1.45 (s, 18H), 1.44 (s,9H), 1.37-2.04 (m, 4H); --C NMR (75 MHz, CDCI3) 5
167.0, 154.1, 152.6, 148.4, 144.8, 144.5, 138.9, 137.5, 132.0, 131.5, 128.6, 128.5, 127.5, 127.2, 125.7, 125.5, 125.2, 82.4, 81.6, 53.4, 49.4, 42.5, 33.8, 28.3, 28.1, 27.9; MS (CI) m/z 701 (M+H).
B. l-[4-(3-Aminomethyl-phenyl)-piperidin-l-vl]-l-(5-benzvlamino-pyridin-3-yl)-methanone
trihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using benzyl-{5-[I-(4-{3-[A-,A--bis-(tert-butoxycarbonyl)aminomethyl]-phenyl}-piperidin-l-yl)-methanoyl]-pyridin-3-yl}-carbamic acid dimethyl-ethyl ester, there was prepared l-[-4-(3-aminomethyl-phenyl)-piperidin-l-
vll-1 -(5-benzvlamino-pvridin-3-vl)-methanone trihvdrochloride as a white solid. *H NMR (300 MHz, DMS0-d6) 5 8.45 (br s, 2H), 8.13 (d, J-2.5 Hz, - 8.08 (d, J-1.0 Hz, - 7,54 (s, - 7,47 (s, -7.18-7.45 (m, 8H), 4.50-4.63 (br m, - 4.45 (s, 2H), 4.02-4.12 (m, - 3.99 (AB q, J=5.5 Hz, 2H),

3.05-3.25(m, - 2.70-2.95 (m, 2H), lJ5-l.90(brm, - I.50-I.70 (br m, 3H); MS (ESI) m/z40I (M+H).
EXAMPLE 107 144-(3-Aminomethvl-phenvlVpiperidin-l-vl1-l-{5-[(naphthalen-2-vlmethvlVamino1-pvridin-3--methanone trihydrochloride
A. {5-[l-(4-{3----.A--Bis-(/gr-butoxvcarbonv-aminomethvl]-phenvll-piperidin-l-v--methanovll-
pvridin-3-yll-naphthalen-2-vlmethvl-carbamic acid dimethyl-ethyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 2-(bromomethyl)naphthalene in place of 4-bromo-2-fIuorobenzyl bromide, there was prepared {5-[l-(4-{3-[MA--bis-(rg?-r-butoxvcarbonvnaminomethvn-phenvU-piperidin-l-vn-methanovU-pyridin-3-yPf-naphthalen-2-ylmethvl-carbamic acid dimethvl-ethvl ester as a colorless oil. TLC, 50:50-methylene
chloride:ethyl acetate, Rf- 0.42. -H NMR(300 MHz, CDCI3) 8 8.55 (d, J-I.8 Hz, - 8.13 (d,
J=187,5 Hz, - 7.68-7.83 (m, 3H), 7.60 (s, - 7.54 (br s, - 7.35-7.49 (m, 3H), 7.21-7.29 (m partially obscured, - 7.16 (d, J-7.7 Hz, - 7.08(s, - 7.01 (d, J=7.7 Hz, - 5.00-5.08 (m,
2H), 4.77 (s, 2H), 3.48-3.62 (br m, - 2.59-3.03 (m, 3H), 1.45 (s, 27H), 1.27-1.95 (m, 4H); --c NMR(75MHz, CDCl3)6 166.9, 154.3, 152.6, 148.6, 144.8, 144.7, 138.9, 138.8, 134.9, 133.3, 132.8,
132.2, 131.6, 128.6, 127.7, 126.3, 126.2, 126.0, 125.8, 125.5, 125.3, 125.2,82.4,81.8,53.6,49.4,42.5, 33.2, 28.4, 28.2, 28.0; MS (CI) m/z 752 (M+H).
B. l-[4-(3-Aminomethvl-phenvn-piperidin-l-vl]-l-(5-[fnaphthalen-2-vlmethvn-amino1-pvridin-3-yl}-
methanone trihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using {5-[l-(4-{3-[A-,A--bis-(/er-butoxycarbonyl)aminomethy!]-phenyl}-piperidin-l-yl)-methanoyl}-pyridin-3-yl}-naphthalen-2-ylmethyl-carbamic acid dimethyl-ethyl ester, there was prepared 1 -f4-(3-aminomethvl-phenvl)-piperidin-l-yl]-l-{5-Knaphthalen-2-vlmethvn-amino1-pvridin-3-vll-methanone
trihydrochloride as a as a white solid. - H NMR (300 MHz, DMS0-d6) 6 8.34 (br s, 2H), 8.17 (s, i H),
8.03 (s, - 7.75-7.97 (m, 4H), 5.58-7.77 (m, - 7.25-7.57 (m, 6H), 7.22 (d, J-7.2 Hz, - 4.61 (s, 2H), 4.50-4.68 (m partially obscured, - 4.10-4.35 (m, - 4.00 (AB q, J-5.7 Hz, 2H), 2.91-3.12 (m, - 2.66-2,90 (m,2H), 1.70-1.89(m, - 1.36-1.69 (m, 3H); MS (ESI) m/z 451 (M+H).
EXAMPLE 108 l-[4-(3-Aminomethyl-phenvl)-piperidin-l-yn-l-[5-(4-brQmo-benzyiamino)-pyridin-3-yl]-methanQne trihydrochloride

A. (4-Bromobenzyl)-{5-[l-(4-|3-[A-.7V-bis-(/grNbutoxvcarbonvl)amino-methvl1-phenvl}-piperidin-l-
vl)-methanoyl]-pyridin-3-yl}-carbamic acid dimethyl-ethyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 4-bromobenzyl bromide in place of 4-bromo-2-fluorobenzyl bromide, there was prepared (4-bromob_en_zylj-£5-Xl -(4-{3-[A-. A--bis-(j-gr/-butoxycarbonynamino-methyl1-phenyU-piperidin-1 -yl)-methanoyl]-pyridin-3-yll-carbamic acid dimethyl-ethyl ester as a colorless oil. TLC, 50:50-methylene
chloride:ethyl acetate, Rf= 0.41. -H NMR (300 MHz, CDCI3) 6 8,45-8.51 (m, 2H), 7.56 (br s, -
7.43 (d, J-8.4 Hz, 2H), 7,24-7,30 (m partially obscured, - 7.11 (d, J=8.4 Hz, 2H), 6.96-7.17 (m partially obscured, 3H), 4.83 (s, 2H), 4.77 (s, 2H), 4.75-4.87 (m partially obscured, - 3.65-3.80 (br
m, - 3.05-3.23 (brm, - 2.69-2.91 (m, 2H), 1.45 (s, 18H), 1.43 (s,9H), 1.30-2.00 (m, 4H); --C NMR(75MHz, CDCl3)5 166.8, 154.0, 152.5, 148.4, 144.7, 138.9, 138.7, 136.5, 132.1, 131.8, 131.7,
131.5, 129.0, 128.6, 125.7, 125.5, 125.2, 121.4, 82.4, 81.9, 52.8, 49.3, 42.5, 33.5, 28.3, 28.1, 27.9; MS (CI)m/z781 (M+H).
B. l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-[5-(4-bromo-ben_zy_h
methanone trihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using (4-bromobenzyl)-{5-[l-(4-{3-[A-,7V-bis-(r-rr-butoxycarbonyl)amino-methyl]-phenyl}-piperidin-l-yl)-methanoyl]-pyridin-3-yl}-carbamic acid dimethyl-ethyl ester, there was prepared l-[4-(3-aminomethvl-phenvn-piperidin-l-yl]-l-[5-(4-bromo-benzylaminoVpvridin-3-yl]-methanone
trihydrochloride as a cream-colored solid, -H NMR (300 MHz, DMSO-d6) 6 8.34 (br s, 2H), 8.11 (d,
J-=2.5 Hz, 1H), 8.04 (s, 1H), 7.52 (d, J=-8.5 Hz, 2H), 7.34 (d, J==8.5 Hz, 2H), 7.15-7.67 (m, 5H), 4.49-4.64 (br m, - 4.42 (s, 2H), 4.05-4.15 (m, - 4.01 (AB q, J=5.7 Hz, 2H), 3.00-3.20 (m, - 2.70-2.90 (m, 2H), 1.72-1.88 (m, 1H), 1.45-1.70 (m, 3H); MS (ESI) m/z 479 (M+H).
EXAMPLE 109 3-[(5-|l-[4-(3-Aminomethyl-phenyl)piperidin-l-yl1-methanoyll-pyridin-3-ylamino)-methyn-benzonitrile trihydrochloride
A. i5-[l-(4-|3-[yV,A--Bis-(/er/-butoxycarbonyl)amino-methyl]-phenyl}-piperidin-l-yn-methanQyl]-pyridin-3-yl|-(3-cyano-benzyn-carbamic acid dimethyl-ethyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but a-bromo-m-tolunitrile in place of 4-bromo-2-fluorobenzyl bromide, there was prepared |5-f l-(4-|3--A-,A--bis-(/gr-butoxycarbony-amino-methyl1-phenyl}-piperidin-l-yl)-methanoyl]-pyridin-3-yl}-(3-cyano-benzyl}-carbamic acid dimethyl-ethyl ester as a yellow oil. TLC, 50:50-methylene chloride:ethyl acetate, Rf=

0,44. -H NMR (300 MHz, CDCI3) 5 8.46-8.52 (m, 2H), 7,51-7,65 (m, 3H), 7.36-7.50 (m, 2H), 7.24-
7.31 (m partially obscured, - 7.03-7.18 (m, 3H), 4.92 (s, 2H), 4.79-4.92 (m partially obscured, -4.78 (s,2H), 3.70-3.85 (brm, - 3.10-3.28 (brm, - 2.71-2.99 (m, 2HX 1.45 (s, 18H), 1.44 (s,
9H), 1.30-2.05 (m partially obscured, 4H); --C NMR (75 MHz, CDCI3) 5 166.7, 153.8, 152.5, 148.1,
145.2, 144.7, 139.2, 138.9, 138.7, 132.1, 131.9, 131.5, 131.2, 130.6, 129.6, 128.6, 125.6, 125.5, 125.2,
118.2, 112.9, 82.4, 80.6, 52.8, 49.3, 42.4, 33.5, 28.3, 28.0, 27.9; MS (CI) m/z 727 (M+H).
B. 3-[(5-{l-r4-(3-Aminomethvl-phenvnpiperidin-l-vl]-methanovll-pvridin-3-vlamino)-methvl1-benzonitrile trihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using {5-[l-(4-{3-[A-,A--biS-(-er/-butoxycarbonyl)amino-methyl]-phenyl}-piperidin-l-yl)-methanoyl]-pyndin-3-yl}-(3-cyano-benzyl)-carbamic acid dimethyl-ethyl ester, there was prepared 3-[(5-( l-[4-(3-aminomethyl-phenyl)piperidin-l-yl]-methanoy]}_-pyridin-3-vlamino)-methvl]-be-zonitrile trihydrochloride as a
white solid. -H NMR (300 MHz, DMS0-d6) 5 8.33 (br s, 2H), 8,13 (d, J-2.5 Hz, - 8.02 (s, -
7.80-7.91 (m, - 7.63-7.75 (m, 2H), 7.42-7.58 (m, 2H), 7,20-7,7,41 (m, 4H), 4.51 (s, 2H), 4.40-4.62 (m partially obscured, - 4.10-4.25 (m, - 4.00 (AB q, J=5.7 Hz, 2H), 2.90-3.20 (m, - 2.72-2.93 (m, 2H), 1.75-1.90 (br m, - 1.45-1.70 (br m, 3H); MS (ESI) m/z 426 (M+H).
EXAMPLE 110 l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-[5-(2-chloro-4-fluoro-benzylamino)-pyridin-3-yn-methanonc trihydrochloride
A. l5-ri-(4-{3-rA-,A--Bis-(/grr-butoxycarbonynaminomethyl1-phenyll-piperidin-l-yl)-methanoyn-
pyridin-3-yU-(2-chloro-4-fluoro-benzyl)-carbamic acid dimethyl-ethyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 2-chloro-4-
tluorobenzyl bromide in place of 4-bromo-2-fluorobenzyl bromide, there was prepared l5-[l-(4-{3-
[7V,A--bis-(-g/-/-butoxvcarbonyl)aminomethyn-phenylj-piperidin-l-yl)-methanovl]-pvridin-3-yl}-(2-
chloro-4-fluoro-ben2yl)-carbamic acid dimethyl-ethyl ester as a colorless oil. TLC, 50:50-methylene
chloride:ethyl acetate, Rf- 0.48. -H NMR (300 MHz, CDCI3) 5 8.51 (d, J-2.2 Hz, - 8.46 (d, J=1.8
Hz, - 7.62 (s, - 7.24-7.34 (m, 2H), 7.04-7.19 (m, 4H), 6.97 (td, J-8.2, 2.5 Hz, - 4.96 (s, 2H), 4.77 (s, 2H), 4.75-4.90 (m partially obscured, - 3,70-3.85 (brm, - 3.05-3.25 (br m, 1H),2.70-
2.90(m, J-21.45, sHz, 18H), 1.44(s,9H), 1.30-2,05 (m, 4H); --C NMR (75 MHz, CDCI3) 6 166.9, 161.8 (d, 250.1), 153.8, 152.6, 148.1, 144.7, 144.6, 138.9, 138.6, 133.6 (d, 9.7), 131.8, 131.7, 130.8(d, 3.4), 129.8 (d, 7.6), 128.6, 125.7, 125.6, 125.2, 117.0 (d, 24.9), 114.3 (d, 21.4), 82.4, 82.1, 50.3, 49.4,
42.5, 33.8, 28,3, 28.1, 27.9; --F NMR (282 MHz, CDCI3) 6 -112.0; MS (CI) m/z 754 (M+H).

B. l-[4-(3-Aminomethvl-phenvl)-piperidin-l-vl]-l-[5-(2-chloro-4-fluoro-benzvlamino)-pyridin--
methanone trihydrochloridc
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using{5-[I-(4-{3-
[A-,A--bis-(/er-butoxycarbonyl)aminomethyl]-phenyI}-piperidi--!-yl)-methanoyl]-pyridin-3-yi}-(2-
chloro-4-fluoro-benzyl)-carbamic acid dimethyl-ethyl ester, there was prepared l-r4-(3-aminomethyl-
phenyl)-piperidin-l-vl1-l-[5-(2-chloro-4-fluoro-benzvlamino)-pvridin-3-vl]-methanQne
trihvdrochloride as a white solid. 1H NMR (300 MHz, DMSO-d6) 6 8.34 (br s, 2H), 8.15 (d, 5=2.5
Hz, - 8.07 (s, - 7.12-7.55 (m, 8H), 4.50-4.65 (br m, - 4.46 (s, 2H), 4.12-4.24 (br m, -4.00 (AB q, J-5.8 Hz, 2H), 3.05-3.20 (br m, - 2.70-2.90 (m, 2H), 1.72-1.90 (br m, - 1.48-1.73
(br m, 3H); l-p NMR (282 MHz, DMS0-d6) 6 -112.6; MS (ESI) m/z 453 (M+H).
EXAMPLE 111 l-[--(3-Aminomethyl-phenyl)-piperidin-l-vl1-l-15-(4-trifluoromethoxv-benzvlamino)-pyridin-3-yl]-methanone trihydrochloride
A. {5-[l-(4-|3-rA-.A--Bis-(ferf-butoxvcarbonvl)amino-methvl]-phenvll-piperidin-l-ylj-methanQyll-
pvridin-3-vl}-(4-trifluoromethoxv-benzvn-carbamic acid dimethvl-ethvl ester
By proceeding in a similar manner to the method described in EXAMPLE I05C, but using 4-(trifluoromethoxy)benzyl bromide in place of 4-bromo-2-fluorobenzyl bromide, there was prepared f5-ri-(4-(3-rA-.A--bis-(fgrr-butoxycarbonvl)amino-methyl]-phenyl}-piperidin-l-vl)-methanovl1-pvridin-3-vU-(4-trifluoromethoxv-benzvl)-carbamic acid dimethyl-ethyl ester as a colorless oiK TLC,
50:50-methylene chlorideiethyl acetate, Rf = 0.48. -H NMR (300 MHz, CDCI3) 5 8.45-8.53 (m, 2H),
7.60 (s, 1H), 7.20-7.30 (m, 3H), 7.05-7.20 (m, 5H), 4,88 (s, 2H), 4.77 (s, 2H), 4.75-4.90 (m partially obscured, - 3.70-3.84 (br m, - 3.08-3.24 (brm, - 2.70-2.93 (m, 2H), 1.45 (s, 18H), 1.44(s,
9H), 1.35-2.05 (m,4H); l-c NMR(75 MHz, CDCI3) 5 166.9, 154.0, 152.6, 148.3,144.7, 144.6,
138.9, 138.8, 136.3, 132.2, 131.9, 128.7, 128.6, 125.7, 125.6, 125.2, 121.2, 120.1 (q, 262), 82.4, 82.0,
52.7, 49,4, 42.5, 32.3, 28.3, 28.1, 27.9; l-p NMR (282 MHz, CDCI3) 6 -57.4; MS (CI) m/z 786
(M+H).
B. ]-[4-(3-Aminomethvl-phenvl)-piperidin-l-vl1-l-[5-(4-trj_f1uoromethoxy-benzylamino)-pyridin-3-
vl]-methanone trihvdrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using{5-[l-(4-{3-[JV,A--bis-(rer-butoxycarbonyl)aminO-methyl]-phenyl}-piperidin-l-yl)-methanoyl]-pyridin-3-yl}-(4-trifluoromethoxy-benzyl)-carbamic acid dimethyl-ethyl ester, there was prepared l-[4-(3-

aminomethvl-phenvn-piperidin-l-vl]-l-[5-(44rifluoromethoxv-benzvlaminQ)-pvridin-3-vl1-meth---
trihvdrochloride as a white solid. -H NMR (300 MHz, DMS0-d6) S 8.35 (br s, 2H), 8.12 (d, J-2,8
Hz, 1H), 8.05 (s, 1H), 7.20-7.75 (m, 9H), 4.50-4.65 (m, 1H), 4.48 (s, 2H), 4.05-4.20 (m, 1H), 4.00 (AB
qj=5.9 Hz, 2H), 3.05-3.25 (m, - 2.70-2.90 (m, 2H), 1.75-1.90 (m, - 1.50-1.70 (br m, 3H); --F NMR (282 MHz, DMSO-d6) 6 -56.3; MS (ESI) m/z 485 (M+H).
EXAMPLE 112 l-r4-(3-Aminomethyl-phenvl)-piperidin-l-yl]-l-l5-[(pvridin-3-ylmethyl)-amino1-pvridin-3-vl}-methanone tetrahvdrochloride
A. |5-f N(4-{3-rA-.A--Bis-(/-grNbutoxycarbonvnamino-methvl1-phenyl}-piperidin-l-vlVmethanoyl1-
pyridin-3-yl|-pyridin-3-vlinethvl-carbamic acid dimethyl-ethyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 3-(chloromethyl)pyrldine hydrochloride in place of 4-bromo-2-fluorobenzyl bromide, there was prepared l5-[ I-(4-{3-[A-.A--bis-(ferr-butoxycarbonvnamino-methyl]-pheny| }-piperidin-l-yl)-methanovl]-pyridin-3-yU-pvridin-3-y!methyl-carbamic acid dimethyl-ethyl ester as a colorless oil, TLC, 15:85-
isopropyl alcohol:methylene chloride, Rf = 0.54. 1H NMR (300 MHz, CDCI3) 6 8.46-8.56 (m, 4H),
7.53-7.62 (m, 2H), 7.22-7.31 (m partially obscured, 2H), 7.05-7.18 (m, 3H), 4.90 (s, 2H), 4.77 (s, 2H), 4.75-4.99 (m partially obscured, - 3.69-3.83 (brm, - 3.05-3.25 (brm, - 2.70-2.96 (m, 2H),
1.45(5, 18H), 1.44 (s,9H), 1.20-2.03 (m, 4H); --C NMR (75 MHz, CDCI3) S 166.8, 154.0, 152.6,
149.1, 149.0, 148.6, 144.9, 144.7, 138.9, 138.7, 135.1, 133.1, 132.4, 131.9, 128.7, 125.7, 125.6, 125.3, 123.6, 82.5, 82.2, 51.2, 49.4, 42.6, 33.9, 28.4, 28.2, 28.0; MS (CI) m/z 702 (M+H).
B. l-|-4-(3-Aminomethyl-phenyn-piperidin-l-yl1-l-|5-r(pyridin-3-ylmethyn-amino1-pyridin-3-yl}-
methanone tetrahydrochloride
{5-[l-(4-{3-[N,N-Bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidin-l-yl)-methanoyl]-pyridin-3-yl}-pyridin-3-ylmethyl-carbamic acid dimethyl-ethyl ester (0.0250 g, 0.0356 mmol) was treated with 5-6 M HCl in isopropanol (1.0 mL, 8.0 mmol) and stirred at ambient temperature. After 90 minutes the reaction mixture was diluted with methyl alcohol (0.5 mL) and stirring was continued for an additional 75 minutes. Dripping the reaction solution into ether (40 mL) with vigorous stirring afforded a white precipitate which was collected by filtration, washed with fresh ether (3.0 mL), and dried to afford l-[4-(3-aminomethyUphenyn-piperidin-l-yl]-l-l5-[(pvridin-3-ylmethvlVamino]-
pvridin-3-yll-methanone tetrahvdrochloride (0.0160 g): -H NMR (300 MHz, DMSO-d6) S 8.60-8.95 (m, 2H), 8.39 (br s, 2H), 8.29 (d, J=8.0 Hz, 1H), 7.97-8.25 (m, 2H), 7.65-7.85 (m, 2H), 7.47 (d, J-8.0 Hz, 2H), 7.20-7.38 (m, 3H), 4.63 (s, 2H), 4.43-4.61 (m partially obscured, - 4.00 (AB q, J-5.8 Hz,

2H), 3.05-3.25 (m partially obscured, - 2.72-2.95 (m, 2HX 1.80-1.88 (m, - 1.47-1.77 (m, 3H); MS(CI)m/z402(M+H).
EXAMPLE 113 l-[4-(3-Aniinomethyl-phenyl)-piperidin-l-yn-l-{5-r(pyridin-2-ylmethyn-amino1-py methanone tetrahydrochloride
A. l5--l-(4-(3-[iV.A--Bis-(fer-butoxvcarbonvl)arnino-rnethvl1-phenvU-piperidin-l-v--rnethanovl--
pvridin-3-vll-pyridin-2-ylmethyl-carbamic acid dimethyl-ethyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 2-(chloromethyl)pyridine hydrochloride in place of 4-bromo-2-fluorobenzyl bromide, there was prepared {5-ri-(4-{3-|-7V../V-bis-(rgrr-butoxvcarbonvnamino-methvl]-phenvl)-piperidin-l-vn-methanQvl]-pyridin-3-vl}-pyridin-2-ylmethyl-carbamic acid dimethyl-ethyl ester as a colorless oil. TLC, 50:50-
methylene chloride:ethyl acetate, Rf-0.09, -H NMR(300 MHz, CDCI3) 6 8.67 (d, J=2.3 Hz, -
8.52 (d, J=4.7 Hz, - 8.44 (d, J-=1.8 Hz, - 7.81 (s, - 7,59-7.72 (m, - 7.22-7.31 (m partially obscured, 2H), 7.00-7.20 (m, 4H), 4.97 (s, 2H), 4.77 (s, 2H), 4.72-4.90 (m partially obscured, 1H), 3.74-3.89 (brm, - 3.04-3.25 (br m, - 2.69-2.94 (m, 2H), L45 (s, 18H), 1.41 (s, 9H), 1.23-2.03 (m partially obscured, 4H); MS (CI) m/z 702 (M+H).
B. l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(5-[(pyridin-2-ylmethvn-amino]-pvridin-3-vU-
methanone tetrahydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 112B, but using{5-[l-(4-{3-[A-,----bis-(rt-r-butoxycarbonyI)amino-methyl]-phenyl}-piperidin-l-yl)-methanoyl]-pyridin-3-yl}-pyridin-2-ylmethyl-carbamic acid dimethyl-ethyl ester, there was prepared 1 -[4-(3-aminomethvl-phenvl)-piperidin-l-vl1-l-l5-r(pvridin-2-ylmethyl)-amino1-pyridin-3-yU-methanone tetrahydrochloride as a white solid. MS (ESI) m/z 402 (M+H).
In a similar manner to the methods described in EXAMPLES 105 and 112, the following compounds are prepared:
EXAMPLE 114 l-[4-(3-Aminomethyl-phenyn-piperidin-l-yl]-l-{5-[(pyridin-4-vlmethvn-amino1-pyridin-3-yl}-methanone tetrahydrochloride;
EXAMPLE 115 l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(3-benzylamino-phenyn-methanone dihydrochloride;

A. [3-(4-|3-rA-,A--Bis-(tert-butoxvcarbonvl)amino-methvl]-phenvl}-piperidine-l-carbQnvn-phenyl]-
carbamic acid fer/-butyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105B, but using 3-(Boc-amino)benzoic acid in place of 5-fer/-butoxycarbonylamino-nicotinic acid, there was prepared [3-(4-{3-[A-.A--bis-(tert-butoxycarbonyl)amino-methyl1-phenyU-piperidine-l-carbonvn-phenyl]-carbamic
acid tert-butvl ester as a white solid. -H NMR (300 MHz, CDCI3) 6 7.40-7.50 (m, 2H), 7.22-7.37 (m,
2H), 7.04-7.15 (m, 4H), 4.77-4.90 (br m, - 4,76 (s, 2H), 3.81-3.96 (br m, - 3.05-3.20 (br m, -2.68-2.90 (m, 2H), 1.52 (s, 9H), 1.45 (s, 18H), 1.35-1.85 (m partially obscured, 4H)); MS (CI) m/z 610 (M+H).
B. Benzvl-r3-(4-|3-rA-.A--Bis-(tert-butoxycarbonvl)amino-methyl]-phenvll-piperidine-l-carbonyn-
phenyll-carbamic acid -grf-butyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using benzyl bromide in place of 4-bromo-2-fIuorobenzyl bromide and using [3-(4-{3-[7V-,iV-bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid tert-huty\ ester, there was prepared benzyl-[3-(4-{3-[A-.A/--Bis-(tert-butoxvcarbonynamino-methyn-phenyU-piperidine-
]-carbonyn-phenvl]-carbamic acid tert-buty\ ester as a white solid. -H NMR (300 MHz, CDCI3) 5
7.03-7.34 (m, 13H), 4.84 (br s, 2H), 4.78-4.90 (m partially obscured, - 4.77 (s, 2H), 3.69-3.85 (br m, - 2.90-3.10 (brm, - 2.65-2.88 (m, 2H), 1.45 (s, 18H), 1.41 (s, 9H), 1.35-1.95 (m partially obscured, 4H)); MS (CI) m/z 700 (M+H).
C. l-[4-(3-Aminomethyl-phenyn-piperidin-l-yl]-l-(3-benzylamino-phenvl)-methanone
dihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using prepared benzyl-[3-(4-{3-[A-,jV-Bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenylj-carbamic acid /er-butyl ester, there was prepared l-[4-(3-aminomethyl-phenyn-piperidin-l-yl1-l-(3-benzylamino-phenvn-methanone dihydrochloride as a white solid. MS (ESI) m/z 400 (M+H).
EXAMPLE 116 l-(4-(3-Aminomethyl-phenvn-piperidin-l-yl]-l-{3-r(naphthalen-2-vlmethyI)-amino1-phenyU-methanone dihydrochloride;
A. f3-(4-{3-[./V.A--Bis-(fgrf-butoxycarbonyl)amino-methvl1-phenyU-piperidine-l-carbonvn-phenyl]-naphthalen-2-ylmethyl-carbamic acid tert-huty\ ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 2-(bromomethyl)naphthalene in place of 4-bromo-2-fluorobenzyl bromide and using [3-(4-{3-[7V,A--bis-

(tert-butoxycarbonyI)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyi]-carbamic acid tert-bnty\ ester, there was prepared [3-(4-{3-[A-.A--bis-(ferr-butoxycarbQnyl)amino-methyl]-phenyU-piperidine-l-carbonvn-phenvl]-naphthalen-2-vlmethvl-carbamic acid tert-b\xtv\ ester as a white solid. MS (ESI) m/z 650 (M+H).
B. l-(4-(3-Aminomethvl-phenvl)-piDeridin-I-vn-l-(3-frnaphthalen-2-vlmethvl)-aminol-phenvl}-
methanone dihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using [3-(4-{3-
[A-,A--Bis-(tert-butoxycarbonyI)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-naphthaIen-2-
yimethyl-carbamic acid -e-r-butyl ester, there was prepared l-{4-(3-aminomethvl-phenvl)-piperidin-l-
vl]-l-{3-r(naphthalen-2-vlmethyl-)-amino]-phenvU-methanone dihydrochloride as a white solid. MS
(ESI) m/z 450 (M+H).
EXAMPLE 117 3-[(3-{l-r4-(3-Aminomethyl-phenyl)-piperidin-l-vn-methanoyU-phenvlamino)-methyl]-benzonitrile dihydrochloride;
A. [3-(4-l3-W.iV-Bis-(/gr-b-toxycarbony-amino-methyl]-phenyl|-piperidine-l-carbonyl)-phenyn-(3-
cyano-benzyl)-carbamic acid tert-butyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using a-bromo-m-tolunitrile in place of 4-bromo-2-fluorobenzyl bromide and using [3-(4-{3-[A-,7V-bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid tert-buXy\ ester, there was prepared [3-(4-{3-riV.A--bis-(/g/-f-butoxycarbonyl)amino-methyl1-phenyll-piperidine-l-carbonyl)-pheny]]-(3-cyano-benzyl)-carbamic acid tert-butY\ ester as a white solid. MS (CI) m/z 725 (M+H).
B. 3-r(3-l 1 -[4-(3-Aminomethyl-phenyn-piperidin-l-yl1-methanoyU-phenylamino)-methyl]-
benzonitrile dihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE ] 05D, but [3-(4-{3-[A-,jV-bis-(/-rr-butoxycarbonyI)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-(3-cyano-benzyl)-carbamic acid -er/-butyl ester, there was prepared 3-[(3-l 1 -r4-(3-aminomethyl-phenyn-piperidin-1 -yl]-methanoyll-phenylamino)-methyl]-benzonitrile dihydrochloride as a white solid. MS (ESI) m/z 425 (M+H).
EXAMPLE 118 l-[4-(3-Aminomethyl-phenyn-piperidin-l-yl]-l-[3-(4-bromo-benzylaminQ)-phenvI]-methanone dihydrochloride;

A. (4-BrQmO-benzvlV[3--4-{3-[A-,A--bis-(rer-butoxvcarbonv-amino-methvl]-phcnvl)-piperidine-l-
carbonvn-phenyll-carbamic acid tert-bui\l ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 4-bromobenzyl bromide in place of 4-bromo-2-fluorobenzyl bromide and using [3-(4-{3-[A-,A--bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid tert-buXy\ ester, there was prepared (4-bromo-benzvlVp-(4-(3-[A-.7V-bis-(/-gr/-butoxvcarbonvl)amino-methvl]-phenvU-piperidine-l-carbonvn-phenvl1-carbamic acid tert-butyl ester as a clear oil. MS (CI) m/z 778 (M+H),
B. l-[4-(3-Aminomethvl-phenvlVpiperidin-l-vn-l-[3-(4-bromo-benzylamino)-phenvl]-methanQne
dihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using (4-bromo-benzyl)-[3-(4-{3-[MA--bis-(rt?rr-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenylj-carbamic acid tert-buty] ester, there was prepared l-r4-n-aminomethyl-phenvn-pipcridin-l-yn-l-[3-(4-bromo-benzylaminQVphenyn-methanone dihydrochloride as a white solid. MS (ESI) m/z 480 (M+H).
EXAMPLE 119 l-r4-(3-Aminomethyl-phenyn-piperidin-l-vl1-l-{3-[(pyridin-2-ylmethylVamino1-phenyll-methanone trihvdrochloride;
A. [3-(4-{3-[A-.#-Bis-(rgr/-butoxvcarbonyl)amino-methvl]-phenyli-piperidinc-l-carbonyl)-phenyl]-
pvridin-2-ylmethyl-carbaiTiic acid tert-buty\ ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 2-picolyI chloride hydrochloride in place of 4-bromo-2-fluorobenzyl bromide and using [3-(4-{3-[A-,A--bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamicacid teri-buty\ ester, there was prepared [3-(4-{3-[A-.A--bis-(rgr-b-toxycarbony-amino-methyn-pheny-l-piperidine-l-
carbonyl)-phenylJ-pvridin-2-ylmethyl-carbamic acid tert-bwtyl ester as a white solid. -HNMR(300 MHz, CDCI3): 5 8.53 (d, - 7.60-7.70 (m, 2H), 7.29-7.37 (m, 4H), 7.08-7,24 (m, 5H), 4.97 (s, 2H),
4.70-4.90 (m partially obscured, - 4.77 (s, 2H), 3.75-3.95 (br m, - 2.65-3.20 (br m, 3H), 1.40-2.00 (m partially obscured, 4H), 1.45(s, 18H), 1.39(s,9H). MS (ESI): m/z 701 (M+H).
B. l-f4-(3-Aminomethvl-phenvl)-piperidin-l-yl1-l-l3-r(pyridin-2-vlmethyl)-amino1-pheny||-
methanone trihvdrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using [3-(4-{3-[N,Ar-Bis-(-erNbutoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-pyridin-2-

ylmethyl-carbamic acid tert-buty\ ester, there was prepared l-(4-(3-aminomethvl-phenvl)-piperidin-l-
vl1-l-l3-[(pvridin-2-vlmethvn-amino1-phenvU-methanone trihydrochloride as a lisht yellow solid. -H NMR [300 MHz, (€03)280]: 5 8.69 (d, - 8.34 (br s, 3H), 8.19 (tr, - 7.73 (d, - 7.63 (tr, -7.25-7.42 (m,4H), 7.14 (tr, lH),6.68(d, 1H),6.61 (m, 2H), 4.40-4.70 (br m partially obscured, -4.61 (s,2H),4.01 (q,2H), 3.70-3.95 (brm partially obscured, - 2.90-3.15 (brm, - 2.65-2.90 (br m, 2H), 1.35-1.95 (brm,4H). MS (ESI): m/z401 (M+H).
EXAMPLE 120 l-[4-(3-Aniinoniethvl-phenyn-piperidin-l-vl]-l-(3-[(pvridin-3-ylrncthyl)-arnino]-phenyU-methanone trihydrochloride:
A. r3-(4-|3-[A-.7\--Bis-(-gr/-butoxycarbonynamino-methyl]-phenyll-piperidine-l-carbonvl)-phenyl]-
pyridin-3-ylmethyl-carbamic acid tert-buiyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 3-picolyl chloride hydrochloride in place of 4-bromo-2-fluorobenzyl bromide and using [3-(4-{3-[A-,A--bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid tert-buty\ ester, there was prepared [3-(4-{3-[A-.7V-bis-(fg/-f-butoxycarbonynamino-methyl]-phenyU-pipcridine-l-
carbonyD-phenyll-pyridino-ylmethyl-carbamic acid -grNbutyl ester as a cream oil. - H NMR (300 MHz, CDCI3): 6 8.49 (br s, 2H), 7.57 (d, - 7.33 (m, - 7.07-7.24 (m, 8H), 4.70-4.95 (m partially
obscured, - 4.85 (s, 2H), 4.77 (s, 2H), 3.65O.90 (br m, - 2.65-3.15 (br m, 3H), 1.40-2.00 (m partially obscured, 4H), 1.45 (s, 18H), 1.41 (s, 9H). MS (ESI): m/z701 (M+H).
B. l-{4-(3-Aminomethyl-phcnyn-piperidin-l-vl]-l-{3-[(pyridin-3-ylmethyl)-amino1-pheny||-
methanone trihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using [3-(4-{3-[A-,A--Bis-(re/-r-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-I-carbonyl)-phenyl]-pyridin-3-ylmethyl-carbamic acid /er/-butyl ester, there was prepared l-(4-(3-aminomethyl-phenyl)-piperidin-l-
vl]-l-{3-[(pyridin-3-ylmethyn-amino1-phenyU-methanone trihydrochloride as a light yellow solid. - H NMR[300MHz,(CD3)2SO]:6 8.81 (s, lH),8.70(d, - 8.34 (m, 4H), 7.86 (tr, - 7.25-7.41 (m, 4H), 7.14 (tr, - 6.67 (d, - 6.59 (m, 2H), 4.40-4.70 (br m partially obscured, - 4.50 (s, 2H), 4.01 (q,2H), 3.70-3.90 (brm partially obscured, - 2.90-3.15 (br m, - 2.65-2.90 (br m, 2H), 1.35-1.95 (br m, 4H). MS (ESI): m/z 401 (M+H).
EXAMPLE 121 l-[4-(3-Aminomethyl-phenyn-piperidin-l-vl1-l-(3-[(pyridin-4-VlmethviVamino]-phenyU-methanone trihydrochloride.

A. [3-(4-{3--A-.7V-Bis-(fgr-butoxycarbonvl)amino-methyl]-phenyl}-piperidine-l-carbony---
pvridin-4-vlmethvl-carbamic acid tert-buty\ ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 4-picolyl chloride hydrochloride in place of 4-bromo-2-fluoroben2yl bromide and using [3-(4-{3-[A-,A--bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid /-r/-butyl ester, there was prepared [3-(4-|3-[A-.A--bis-(tert-butoxycarbQnyl)amino-methyl]-phenyl}-piperidine-l-
carbonvl)-phenvl1-pyridin-4-ylmethyl-carbamic acid -grf-butyl ester as a cream oil. - H NMR (300 MHz, CDCI3): 5 8.55 (br d, 2H), 7.33 (q, 2H), 7.06-7.26 (m, 8H), 4.70-4.90 (m partially obscured,
- 4.84 (s, 2H), 4.77 (s, 2H), 3.70*3.90 (br, - 268-3.15 (brm, 3H), 1.40-2.00 (m partially obscured, 4H), 1.45 (s, 18H), 1.41 (s, 9H). MS (ESI): m/z 701 (M+H).
B. l-{4-(3-Aminomethyl-phenylVpiperidin-l-yl]-l-f3-[(pyridin-4-ylmcthyn-amino1-phenyl}-
methanone trihydrochloridc
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using [3-(4-{3-[A-,A--Bis-(rer-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-pyridin-4-ylmethyl-carbamic acid tert-huty\ ester, there was prepared l-|4-(3-aminomethyl-phenyl)-piperidin-l-
yl]-l-{3-[(pyridin-4-vlmethyl)-amino1-phenyl}-methanone trihydrochloride as a cream solid. 1H NMR [300 MHz, (003)280]: 5 8.76 (br s, 2H), 8.33 (br s, 3H), 7.87 (d, 2H), 7.24-7.41 (m, 4H), 7.13 (tr, - 6.65-7.00 (br, - 6.56-6.64 (m, 3H), 4.40-4.70 (br m partially obscured, 1H),4.61 (s, 2H), 4.01 (q,2H), 3.70-3.90 (brm partially obscured, - 2.90-3.15 (brm, - 2.65-2.90 (br m, 2H), 1.35-1.95 (br m, 4H). MS (ESI): m/z 401 (M+H).
EXAMPLE 122 3-[l-(5-Phenvlethynvl-furA11-2-carbonvn-piperidin-4-vl]-benzvlaminetrifluoroacetate
A. 4-oxo-piperidine-l-carboxylic acid (trimethylsilyl) ethyl ester
A solution of 4-piperidone monohydrate. Hydrochloride (13.55g, 88mmol) 2-trimethyIsilylethyI-p-nitrophenylcarbonate (25.00g, 88mmol) in acetonitrile (300 ml) was treated with triethylamine (50 ml, 359 mmol) and dimethyl-aminopyridine (10.78g, 88mmol) and heated to reflux for 2 hours. The solution was cooled and concentrated to an oil. The residue was dissolved in dichloromethane (300ml) and washed twice with IM hydrochloric acid and twice with IM sodium hydroxide until all of the yellow color was removed from the organics. The organics were then washed with brine, dried over magnesium sulfate and concentrated under vacuum to give 4-oxo-piperidine-l-carboxylic acid
(trimethylsilyl) ethyl ester as colorless oil. (19.35g) -H NMR (CDCI3, 300 MHz): 5 4.24 (2H, t), 3.78
(4H, t), 2.45 (4H, t), 1.05 (2H, t), 0.05 (9H, s) MS (EI) 284(M+CH3CN)

B. 4-(3-Cyano-phenyn-3,6-dihydro-2H-pyridine-l-carboxylic acid 2-trimethvlsilanvl-ethvl ester A solution of lithium hexamethyldisilazide (60 mmol) in anhydrous tetrahydrofuran (150 ml), at -78°C, was treated dropwise with a solution of 4-oxo-piperidine-l-carboxylic acid (trimethylsilyl) ethyl ester (13.30g, 55mmol) in anhydrous tetrahydrofuran (50ml). The addition was over 20 minutes maintaining the internal temperature at -65 to -70°C. This solution was stirred at -78°C for 45 minutes and then treated with a solution of N-phenyltrifluoromethanesulfonimide (19.65g, 55mmol) in anhydrous tetrahydrofuran (75ml). The solution was warmed to 0°C, then stirred at 0°C for 3 hours and then concentrated under vacuum. The residue was dissolved in dichloromethane and washed with water, dried over magnesium sulfate and concentrated to give 2-(trimethylsilyl) ethyl 1,2,3,6-tetrahydro-4- (trifluoromethylsulphonyloxy)-pyridine-l-carboxylate as a yellow oil (22.Ig). The material is used crude, as column chromatography on silica gel or alumina caused_the material to deteriorate. A portion of this material (20,65g, 55mmol) was dissolved in acetonitrile (300 ml) and the solution was treated with 3-cyanoboronic acid (8.90g, 60mmol), 2M sodium carbonate (82.5ml, 165mmol) and lithium chloride (6.98g, 165mmol). The non-homogenous mixture was stirred vigorously and flushed with nitrogen for 5 minutes, then tetrakistriphenylphospine palladium (0) (3.10g, 3mmol). The mixture was heated to reflux (90°C oil bath) for 90 minutes, then cooled and filtered. The red filtrate was concentrated and the residue was partitioned between dichloromethane (3 lots 100ml) and 2M sodium carbonate (200ml). The combined organic extracts were dried over magnesium sulfate and then concentrated under vacuum. The resultant oil was subjected to chromatography silica gel eluting with a mixture of ethyl acetate, heptane and dichloromethane (1:5:1, v/v) to yield 4-(3-cvano-phenyn-3,6-dihvdro-2H-pyridine-l-carboxylic acid 2-trimethvlsilanvl-ethyl
ester as a yellow oil (10-46g). -H NMR (CDCI3, 300 MHz): 8 7.40-7.65 (m, 4H), 6.10 (m, - 4.23
(t, 2H), 4.15 (d, 2H), 3.70 (t, 2H), 2.45 (m, 2H), 1.12 (t, 2H), 0.05 (s, 9H).
C. 4-(3-Aminomethyl-Phenyn--piperidine-l-carboxvlic acid 2-trimethvlsilanvl-ethvl ester
hydrochloride 4-(3-Cyanophenyl)-3,6-dihydro-2H-pyridine-l-carboxylic acid 2-trimethylsilanyl-ethyl ester (10.40g, 32mmol) was dissolved in ethanol (250ml), concentrated hydrochloric acid (3ml, 35mmoI) and 10% palladium on carbon (50% wet, 5.0g) was added. The mixture was hydrogenated at 50 psi for 4 hours then filtered through celite and concentrated. The oily solid obtained was triturated with ether/pentane and 4-(3-aminomethvl-phenvl)-piperidine-l-carboxvlic acid2-trimethylsilanvl-ethvl ester
hydrochloride was obtained as a white solid (7.lOg). -H NMR [(003)280, 300 MHz]: 8 8.38 (br s,
2H), 7.20-7.40 (m, 4H), 4.10 (t, 4H), 3.98 (s, 2H), 2.63-3.00 (m, 3H), 1.75 (m, 2H), 1.50 (m, 2H), 0.94 (t, 2H), 0.02 (s, 9H). LC-MS (ES) 335 (M-+H), 93% TIC.

p. (3-Pipcridin-4-vl-benzvn carbamate Wang resin p-Nitrophenyl carbonate Wang resin (1 l.OOg, ISmmoI) and anhydrous dimethylformamide (100ml) were placed in a peptide synthesis vessel and the resin was allowed to swell for 15 minutes. This was then treated with 4-(3-aminomethyl-phenyl)-piperidine-l-carboxylic acid 2-trimethylsilanyl-ethyl ester hydrochloride (7.50g, 21mmol) in 50ml dimethylformamide, dimethylaminopyridine (0.72, 6mmol) and diisopropylethyl-amine. The peptide vessel was shaken at room temperature for 24 hours, then washed thoroughly with dimethylformamide (x5), methanol (x2), dimethylformamide (x2), methanol (x2), dichloromethane (x3), methanol (x2), dichloromethane (x2), methanol (x3), and dried. The resin was then treated with tetrahydrofuran to swell the resin and then allowed to drain. Then anhydrous tetrahydrofuran (100ml) and tetrabutylammonium fluoride (75ml, IM in tetrahydrofuran) were added and the resin shaken for 18 hours. The resin was drained and washed with tetrahydrofuran (x5), methanol (x3), dichloromethane (x3), methanol (x3), dichloromethane (x3), methanol (x3) and dried to give (3-piperidin-4-yl-benzyl) carbamate Wang resin (12,30g),
E. 3-[ 1 -(5-PhenvlethYnvl-furA11-2-carbonvn-Diperidin-4-vl1-ben2ylamine trifluoroacetate (3-Piperidin-4-yl-benzyl) carbamate Wang resin (60mg, 0.075mmol) suspended in dimethylformamide (3ml) and 5-phenylethynyl-furan 2 carboxylic acid (80mg, 0.38mmol), diisopropylcarbodiimide (48mg, 0.38mmol) and 1-hydroxybenzotriazole (50mg, 0.38mmol) were added. The mixture was shaken at room temperature overnight and washed with dimethylformamide (x5), methanol (x5), dichloromethane then methanol (repeat 5 times). The resin was treated with trifluoroacetic acid and dichloromethane (1:1 v/v, 4m]) for 45 minutes and filtered. The filtrate was concentrated to give 3-[l-(5-phenylethynyl-furA11-2-carbonvl)-piperidin-4-vl]-benzylamine trifluoroacetate as a pale yellow oil (30mg). LC-MS (ES) 385 (M-H) 100% TIC.
In a similar manner to the methods described in EXAMPLE 112, the following compounds set forth in Table 5 were prepared as the trifluoroacetate salts:



























A. {4-[3-A-.A--Di-(fgr-butoxycarbony-aminomethy--phenyl]-pipendin-l-vl|-(3-brQmQ-pheny
methanonc
By proceeding in a similar manner to the method described in EXAMPLE 105B, but using 3-bromobenzoic acid in place of 5-/e?r/-butoxycarbonylamino-nicotinic acid, there was prepared {4-[3-A-,A--di-(-er/-butoxycarbonyl)aminomethyl)-phenyl]-piperidin-l-yl}-(3-bromo-phenyl)-methanone as a colorless oil. MS (CI) m/z 573 (M+H).
B. {443-A-,A--Di-(/gr-butoxvcarbonvi)aminomethvlVphenyl]-piperidin-l-yl}-[l J-4---]terphenvl-3-
yl-methanone
By proceeding in a similar manner to the method described in EXAMPLE 17D, but using 4-biphenylboronic acid in place of l-(5-phenylethyl-pyridine-3-Carbonyl)-4-(pinacolatoboronyl)-l,2,3,6-tetrahyd-o-pyridine and {4-[3-A-,A--di-(/er-butoxycarbonyl)aminomethyl)-phenyl]-piperidin-l-yl}-(3-bromo-phenyl)-methanone in place of N-(tert-butoxycarbonyl)-3-bromo-4-fluoro-benzylamine, there was prepared {4-[3-A-.A--di-(rgr/-butoxvcarbonynaminomethvn-phenvl]-piperidin-l-vl}-[ K r;4M -]terphenvl-3-vl-methanone as a yellow oil. MS (CI) m/z 647 (M+H).
C. [4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-[Kr:4M-]terphenyl-3-yl-methanone hydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using {4-[3-A-,A--
di-(tert-butoxyearbonyI)aminomethyl)-phenyl]-piperidin-l-yl}-[l,r;4-,l-]terphenyl-3-yl-methanone,

there was prepared [4-(3-arninomethyl-phenyI)-piperidin-l-yl]-[l,r;4-,l-]terphenyl-3-yl-methanone hydrochloride as a cream-colored solid. MS (CI) m/z 447 (M+H).
EXAMPLE 345 3-ri-(6-Chloroquinoline-3-carbonvn-piperidin-4-yI]-ben2ylamine di-hydrochloride
A. Ethyl 6-chlQroquinoline-3-carboxvlate
Ethyl 4,6-Dichloroquinoline-3-carboxylate [prepared as described in C. C. Price and R. M. Roberts J. Amer. Chem. Soc. 68, 1204 (1964); C. J. Ohnmacht, Jr, J. Med. Chem. 14, 17 (1971) ] (2.0 g, 7.4 mmol) was added portionwise to a solution of sodium borohydride (1.2 g, 31mmol) in 15 ml of methoxyethanol at about 0°C. The reaction mixture was warmed to room temperature over 3 hours then diluted with ethyl acetate. After standard aqueous workup (dil HCl; saturated NaHC03) the organic layer was dried (NaS04) and concentrated to a residue. The residue was exposed to air oxidation (about 14 days) and extracted repeatedly with boiling heptane. The heptane was removed in
vacuo to yield ethyl 6-chloroquinoline-3-carboxylate as a beige solid. -H NMR [(CDCI3), 300 MHz]:
5 9.38 (bs, - 8.68 (s, - 8.05 (d, - 7.83 (s, 2H), 7.69 (d, - 4.40 (q, 2H), 1.39 (t, 3 H).
MS(El): 236(M++ H).
B. 6-Chloroquinoline-3-Carboxylic acid
Ethyl 6-chloroquinoline-3-carboxylate (0.19 g, 0.81 mmol) was saponified by treatment with dioxane (10 ml) and 10% aqueous sodium hydroxide (10 ml) at reflux for 3 hours. The dioxane was removed under vacuo; the aqueous solution remaining was acidified with HCl. The precipitated product was collected and washed with water to isolate 6-chloroquinoline-3-carboxylic acid as an off-white solid
(0.14 g, 0.67 mmol). -HNMR [(CD3OD), 300 MHz]: 5 9.35 (s, lH),8.95(s, lH),8.17(s, 1H),8.1
(d, 2H), 7.87(d, IH).
C. 7V.A--bis-(fgrr-butoxvcarbonvl)-3-[l-(6-chloroquinoline-3-carbonvn-piperidin-4-vl] benzvlamine
By proceeding in a similar manner to the method described in EXAMPLE IC, but using 6-
chloroquinoline-3-carboxylic acid in place of 5-phenylethynyl-pyridine-3-carboxyIic acid, crude title
compound was prepared. The crude product was purified by flash chromatography (25-50% ethyl
acetate/Heptane) to yield the title compound as a white amorphous solid. -H NMR[(CDCl3), 300
MHz]: 5 8.98 (bs, - 8.20 (s, - 8.05 (d, - 7.88 (s, - 7.72 (d, - 7.08-7.31 (m, 4H), 4.93 (brm, lH),4.78(s, 2H), 3.90(brm, - 3.27 (br m, - 3.95 (br m, - 2.82(m, - 1.6-2.1 (br m,4H), 1.47 (s, 18H).

D. 3-l-l-(6-Chloroquinoline-3-carbonvlVpiperidin-4-vl]-benzvlamine
A/,jV-bis-(/-/-/-butoxycarbonyI)-3-[l-(6-Chloroquinoline-3-carbonyl)-piperidin-4-yl] benzylamine (0.055 g, 0.095 mmol) was treated with a solution of 15% trifluoroacetic acid in methylene chloride (5 ml) at O--C. The reaction was warmed to ambient temperature over 2.5 hr and the solvents were removed in vacuo. The residue was triturated with ether to yield the title compound (0.033 g,
0.087mmol) as an amorphous solid. -H NMR[(CD3)2SO, 500 MHz]: 5 8.95 (s, - 8.44 (s, - 8.20
(s, - 8.07 (d, - 7.84 (d, 2H), 7.23-7.40 (m, 4H), 4.67 (m, - 7.34 (m, 3H), 4.75 (brm, -4.05 (m, 2H), 3.75 (br m, 1H), 3.30 (br m, 1H), 2.80-3.00 (br m, 2H), 1.90 (br m, 1H), 1.6-1.8 (br m,
3H). MS(EI): 380(M++H).
EXAMPLE 346 l-r4-(3-Aminomethvl-phenvn-piperidin-l-vl]-l-(3-benzvlamino-phenvn-methanone dihydrochloride
A. f3-(4-{3-riV.A--Bis-(tert-butQxvcarbonvnamino-methvl]-phenyll-piperidine-l-carbonvn-phenvl1-
carbamic acid tert-butw\ ester
By proceeding in a similar manner to the method described in EXAMPLE 105B, but using 3-(Boc-amino)benzoic acid in place of 5-rerr-butoxycarbonylamino-nicotinic acid, there was prepared [3-(4-{3-l-A-.A--biS-(tert-butoxvcarbonvnaminO-methvl]-phenvU-pipcridine-l-carbonyl)-phenyl1-carbamic
acid tert-buty\ ester as a white solid. - H NMR (300 MHz, CDCI3): 5 7.40-7.50 (m, 2H), 7.22-7.37 (m,
2H), 7.04-7.15 (m, 4HX 4.75-4.90 (br m, - 4.76 (s, 2H), 3.80-3.96 (br m, - 3.00-3.25 (br m, -2.68-2.95 (m, 2H), 1.40-2.05 (m partially obscured, 4H), 1.52 (s, 9H), 1.45 (s, 18H). MS (CI): m/z 610 (M+H).
B. Benzvl-[3-(4-{3-[A-,A--Bis-(tert-butoxycarbonynaminO-methvl]-phenyl}-piperidine-l-carbonyn-
phenylj-carbamic acid tert-butyl ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using benzyl bromide in place of 4-bromo-2-fluorobenzyl bromide and using [3-(4-{3-[A-;A--bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-I-carbonyl)-phenyl]-carbamic acid tert-buty\ ester, there was prepared benzyl-[3-(4-{3-[MA--Bis-(tert-butoxycarbonyl)amino-methyn-phenyU-piperidine-
l-carbonvO-phenyll-carbamic acid -gr/-butyl ester as a white solid. - H NMR (300 MHz, CDCI3): 6
7.03-7.34 (m, 13H), 4.75-4.90 (m partially obscured, - 4.84 (br s, 2H), 4.77 (s, 2H), 3.69-3.85 (br m, - 2.90-3.10 (brm, - 2.65-2.90 (m, 2H), 1.40-2.00 (m partially obscured, 4H), 1.45 (s, 18H), 1.41 (s, 9H). MS (CI): m/z 700 (M+H).
C. l-[4-(3-Aminomethyl-phenvl)-piperidin--l-yl]-l-(3-benzylamino-phenyn-methanone
dihydrochloride

By proceeding in a similar manner to the method described in EXAMPLE 105D, but using prepared benzyl-[3-(4-{3-[A-,A--Bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid tert-hutyl ester, there was prepared l-[4-(3-aminomethvl-phenvl)-piperidin-l-
vl]-l-(3-benzvlamino-phenvl)-mcthanonedihvdrochloride as a white solid, - H NMR [300 MHz, (CD3)2SO]: 5 8.26 (brs,3H), 7.20-7.55 (m,9H), 7,11 (tr, lH),6.66(d, - 6.57 (m, 2H), 4.40-4,70 (br m, - 4.30 (s, 2H), 4.15 (m, - 4.01 (q, 2H), 2.90-3.15 (br m, - 2.65-2.90 (br m, 2H), 1.35-1.95 (br m, 4H). MS (ESI); m/z 400 (M+H).
EXAMPLE 347 l-l4-(3-Aminomethvl-phenvl)-piperidin-l-vn-l-{3-[(naphthalen-2-vlmethvlVamino]-phenvU-methanone dihydrochloride
A, F3-(4-l3-rA/i7V-Bis-(-grNbutoxvcarbonvnamino-methvl]-phenvll-piperidine-l-carbonvl)-phenvn-
naphthalen-2-vlmethyl-carbamic acid tert-buty\ ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 2-(bromomethyl)naphthalene in place of 4-bromo-2-fIuorobenzyl bromide and using [3-(4-{3-[MA--bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid tert-huiyl ester, there was prepared -3-(4-{3--A-.---bis-(-gr-butoxvcarbonvl)amino-methvl]-phenvl|-piperidine-l-
carbonvl)-phenyn-naphthalen-2-vlmethvl-carbamic acid tert-buXyl ester as a white solid. * H NMR (300 MHz, CDCI3): 6 7.61-7.80 (m, 4H), 7.38-7.45 (m, 3H), 6.99-7.34 (m, 8H), 5.00 (br s, 2H), 4.70-
4.90 (m partially obscured, - 4.76 (s, 2H), 3.55-3.75 (br m, - 2.70-2.95 (br m, 2H), 2.55-2.70 (m, - 1.40-1.95 (m partially obscured, 4H), 1.45 (s, 18H), 1.42 (s, 9H). MS (ESI); m/z 650 (M+H).
B. l-{4-(3-Aminomethvl-phenvl)-piperidin-l-vn-l-(3-[(naphthalen-2-vlmethvl)-amino]-phenvl|-
mcthanone dihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using [3-(4-{3-[7V;7V-Bis-(/er-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-]-carbonyl)-phenyl]-naphthalen-2-ylmethyl-carbamic acid tert-butyl ester, there was prepared l-{4-(3-aminomethvl-phenvn-piperidin-l-
yl]-l-i3-[(naphthalen-2-vlmethvn-amino1-phenvll-methanone dihydrochloride as a white solid. - H NMR [300 MHz, (CD3)2SO]: 5 8.22 (br s, 3H), 7.81-7.88 (m, 4H), 7.11-7.54 (m, 8H), 6.69 (d, -6.59 (s, - 6.54 (d, - 4.45-4.65 (m partially obscured, - 4.47 (s, 2H), 4,01 (q, 2H), 3.60-3.80 (m partially obscured, - 2.85-3,05 (br m, - 2.65-2.85 (br m, 2H), 1.30-1.95 (br m, 4H)- MS (ESI): m/z 450 (M+H).

EXAMPLE 348 3-r(3-{l-r4-(3-Aminomethvl-phenvn-pipcridin-l-vl1-methanovll-phenvlamino)-methyl]-benzonh--dihvdrochloridc
A. [3-(4-{3-[--.A--Bis-(rgr-butoxvcarbonv-arnino-rnethvl1-phenvll-piperidine-l-carbonyl)-phenvl]-(3-
cyano-benzvD-carbamic acid tert-buty\ ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using a-bromo-/w-tolunitrile in place of 4-bromo-2-fluorobenzyl bromide and using [3-(4-{3-[jV,A--bis-(tert-butoxycarbonyI)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid tert-buty\ ester, there was prepared [3-(4-f3-[A-.A--bis-(fer/-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-
carbonyl)-phenvl]-(3-cvano-benzyn-carbamic acid rgrr-butyl ester as a white solid. - H NMR (300 MHz, CDCI3): 6 7.06-7.55 (m, 12H), 4.70-4,90 (m partially obscured, - 4.86 (s, 2H), 4.77 (s, 2H),
3.70-3.90 (brm, - 2.95-3.20 (br m, - 2.65-2.95 (brm, 2H), 1.40-2.00 (m partially obscured, 4H), 1.45 (s, 18H), 1.41 (s, 9H). MS (CI): m/z 725 (M+H).
B. 3-[(3-|l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl1-methanoyU-phenylamino)-methvl]-
benzonitrile dihydrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but [3-(4-{3-[A-,A--bis-(rerr-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-(3~cyano-benzyl)-carbamic acid tert~buty\ ester, there was prepared 3-r(3-{l-r4-(3-aminomethyl-phenylVpiperidin-l-yl1-
methanoyU-phcnvlaminoVniethyl]-benzonitrile dihydrochloride as a white solid. - H NMR [300 MHz, (CD3)2SO]: 6 8.18 (br s, 3H), 7.75 (s, - 7.65 (m, 2H), 7.49 (tr, - 7.21-7.35 (m, 4H), 7.08 (tr, - 6.61 (d, - 6.52 (m, 2H), 4.40-4.70 (br m, - 4.33 (s, 2H), 3.98 (q, 2H), 3.50-3.70 (m partially obscured, - 2.85-3,10 (brm, - 2.65-2.85 (brm, 2H), 1.30-1.90 (br m, 4H). MS (ESI): m/z425(M+H).
EXAMPLE 349 l-[4-(3-Aminomethyl-phenyn-piperidin-l-yl1-l-[3-f4-bromo-benzvlamino)-phenyl1-methanone dihydrochloride
A. (4-Bromo-benzyn-[3-(4-l3-[iV.jY-bis-(-erNbutoxycarbonynamino-methyl]-phenyll-piperidine-l-carbonyP-phenylJ-carbamic acid tert-buty\ ester
By proceeding in a similar manner to the method described in EXAMPLE 105C, but using 4-bromobenzyl bromide in place of 4-bromo-2-fluorobenzyl bromide and using [3-(4-{3-[A-,A--bis-(tert-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-phenyl]-carbamic acid tert-buty\ ester, there was prepared (4-bromo-benzyl)-[3-(4-{3-[7\-.A--bis-(tert-butoxvcarbonynamino-methyl]-phenyl}-

piperidine-]-carbonvl)-phenvl]-carbamic acid tert-hut\\ ester as a clear oil. - H NMR (300 MHz, CDCI3): 6 7.41 (d, 2H), 7.06-7.38 (m, 8H), 7.10 (d, 2H), 4.70-4.90 (br m, partially obscured, -
4.78 (s, 2H), 4.77 (s, 2H), 4.25-4.45 (br m, 1H), 3,70-3.85 (br m, 1H), 2.90-3.15 (br m, 1H), 2.65-2.90 (br m, 2H), 1.40-2.00 (m partially obscured, 4H), 1.45 (s, 18H), 1.41 (s, 9H). MS (CI): m/z 778 (M+H).
B. l-[4-(3-Aniinomethvl-phenvn-piperidin-l-vl]-l-[3-(4-brorno-benzvlarnino)-phenvl1-rnethanone
dihvdrochloride
By proceeding in a similar manner to the method described in EXAMPLE 105D, but using (4-bromo-
ben2yl)-[3-(4-{3-[A-,A--bis-(r-/7-butoxycarbonyl)amino-methyl]-phenyl}-piperidine-l-carbonyl)-
phenylj-carbamic acid tert-buty] ester, there was prepared l-[4-n-aminomethvl-phenvn-piperidin-l-
vn-l-r3-(4-bromo-benzylamino)-phenyn-methanone dihvdrochloride as a white solid. - H NMR [300 MHz, (CD3)2SO]: 8 8.28 (br s, 3H), 7.25-7.66 (m, 8H), 7.11 (tr, - 6.64 (d, - 6,55 (m, 2H), 4.45-4.70 (br m, - 4.28 (s, 2H), 4.15 (m, - 4.01 (q, 2H), 2.90-3.15 (brm, - 2.65-2.90 (br m, 2H), 1.30-1.95 (br m, 4H). MS (ESI): m/z 480 (M+H).
EXAMPLE 350 [4-(3-Aminomethvl-phenvl)-piperidin-l-vl]-rLr:4M-]terphenyl-3-vl-mcthanone hydrochloride
A. f443-A-.A--Di-(rerf-butoxvcarbonvnaminomethvn-phenvl1-piperidin-l-Vl)-(3-bromo-phenvlV
methanone
By proceeding in a similar manner to the method described in EXAMPLE 105B, but using 3-
bromobenzoic acid in place of 5-r-r-butoxycarbonylamino-nicotinic acid, there was prepared {443-
7V,7V-di-(rerNbutoxycarbonyl)aminomethyl)-phenyl]-piperidin-l-yl}-(3-bromo-phenyI)-methanoneasa
colorless oil. -H NMR (300 MHz, CDCI3): 5 7.55 (m, 2H), 7.24-7.37 (m, 2H), 7.08-7.16 (m, 4H), 4.75-4.92 (br m, - 4.77 (s, 2H), 3.75-3.90 (br m, - 3.00-3.25 (br m, - 2.70-3.00 (br m, 2H), 1.50-2.00 (m partially obscured, 4H) 1.45 (s, 18H). MS (CI): m/z 573 (M+H).
B. |4-[3-A-.A--Di-agr-butoxvcarbonvnaminomethvn-phenvl1-piperidin-l-yl}-[Kr:4\riterphenyl-3-
yl-methanone
By proceeding in a similar manner to the method described in EXAMPLE 17D, but using 4-biphenylboronic acid in place of I-(5-phenylethyl-pyridine-3-carbonyl)-4-(pinacolatoboronyl)-1,2,3,6-tetrahydro-pyridine and {4-[3-A-,/V-di-(tert-butoxycarbonyl)aminomethyl)-phenyl]-pipendin-I-yl}-(3-bromo-phenyl)-methanone in place of N-(tert-butoxycarbonyl)-3-bromo-4-fluoro-benzylamine, there was prepared (4-[3-MA--di-(/g/-r-butoxvcarbonvnaminomethvl)-phenvl1-piperidin-l-vl|-
[Ur;4M -1terphenyI-3-yl-methanone as a yellow oil. -H NMR (300 MHz, CDCI3): S 7.61-7,71 (m,


butoxycarbonylaminomethyl)phenyl]-piperidine-l-carboxylic acid (3,4-dichloro-phenyl)-amide was isolated as a colorless oil, which was dissolved in dichloromethane (25mL), cooled at 0°C, and treated with trifluoroacetic acid (3mL). The reaction mixture was stirred at room temperature under nitrogen for 2 hours, and concentrated to dryness in vacuo. The residue was dissolved in 20% acetonitrile/water [containing 0.1% trifluoroacetic acid] (9mL) and purified by preparative reverse-phase HPLC (C-l 8, 10 micron reverse-phase column), eluting with 10% to 100% acetonitrile / water (containing 0.1% trifluoroacetic acid). The product fractions were combined and the acetonitrile removed in vacuo. The aqueous residue was frozen and lyophilized to give the title compound as an amorphous white solid
(68mg, 53%). IH NMR [(CD3)280]: 8 8.82 (s, H, NH); 7,88 (s, H); 7.84 (br s, 3H, NH3-); 7.46 (s, H);
7.37-7.22 (m, 5H); 4.24 (br d, 2H); 3.99 (s, 2H); 2.89 (br t, 2H); 2.83-2.70 (m, H); 1.82-1.71 (m, 2H);
1.60-1.44 (m, 2H). IVIS(Ion spray): 378 and 380 (M++1).
EXAMPLE 352 4-(3-Aminomethvl-phenvlVpiperidine-l-carboxvlicacid 2,3-dimethoxvbenzylamide-trif1uoroacetate.
(3-Piperidin-4-yl-benzyl) carbamate Wang resin (EXAMPLE 122D) (60µmol) was suspended in dichloromethane (2mL) and added diisopropylethylamine (0.66 mmol) followed by phosgene (0.6

mmol of a 20% solution in toluene). The reaction mixture was shaken for 5 minutes before washing the resin with toluene (x8). The resin was suspended in DMF (2mL) and to this was added a solution of 2,3-dimethoxybenzylamine (0.6mmol) in DMF (1.5mL) and the reaction mixture shaken for 5 minutes before washing the resin with DMF (x3). The resin was then suspended in dichloromethane (2mL) and treated with TFA (0.5mL). The reaction mixture was shaken for 5 minutes, before the resin was filtered off and the filtrate concentrated to dryness to give the title compound (48|imol) as a pale yellow solid. MS (EI) 383 (M-).
By proceeding in a similar manner to the method described in EXAMPLES 351 AND 352, the following compounds set forth in Table 7 were prepared, as the trifluoroacetate salts:


IN VITRO TEST PROCEDURE
Since all the actions of tryptase, as described in the background section, are dependent on its catalytic
activity, then compounds that inhibit its catalytic activity will potentially inhibit the actions of tryptase.
Inhibition of this catalytic activity may be measured by the in vitro enzyme assay and the cellular
assay.
Tryptase inhibition activity is confirmed using either isolated human lung tryptase or recombinant human p tryptase expressed in yeast cells. Essentially equivalent results are obtained using isolated native enzyme or the expressed enzyme. The assay procedure employs a 96 well microplate (Costar 3590) using L-pyroglutamyl-L-prolyl-L-arginine-para-nitroanilide (S2366: Quadratech) as substrate (essentially as described by McEuen et. al Biochem Pharm, 1996, 52, pages 331-340). Assays are performed at room temperature using 0.5mM substrate (2 x Km) and the microplate is read on a
microplate reader (Beckman Biomek Plate reader) at 405nm wavelength. The inhibition constant (Ki) for particular compounds of the present invention is set forth in Table 8. It was determined using the procedure set forth herein.
Materials and Methods for Tryptase primary screen (Chromogenic assay)
Assay buffer 50 mM Tris (pH 8.2), 100 mM NaCI, 0.05% Tween 20, 50 ug/ml heparin.
Substrate S2366 (Stock solutions of 2.5 mM).
Enzyme Purified recombinant beta Tryptase Stocks of 310 ug/ml. Protocol (Single point determination)
• Add 60 ul of diluted substrate (final concentration of 500 uM in assay buffer) to each well
• Add compound in duplicates , final concentration of 20 uM, volume 20 ul
• Add enzyme at a final concentration of 50 ng/ml in a volume of 20 ul
• Total volume for each well is 100 ul
• Agitate briefly to mix and incubate at room temp in the dark for 30 minutes
• Read absorbencies at 405 nM
Each plate has the following controls -
Totals : 60 ul of substrate, 20 ul of buffer (with 0.2% final concentration of DMSO), 20 ul of
enzyme Non-specific: 60 ul of substrate, 40 ul of buffer (with 0.2% DMSO)

Totals: 60 ul of substrate, 20 ul of buffer (No DMSO), 20 ul of enzyme
Non-specific: 60 ul of substrate, 40 ul of buffer (No DMSO)
Protocol (IC50 and Ki determination)
The protocol is essentially the same as above except that the compound is added in duplicates at the following final concentrations: 0.01, 0.03, 0.1, 0.3, 1, 3, 10 uM (All dilutions carried out manually). For every assay, whether single point or 1C50 determination, a standard compound is used to derive IC50 for comparison. From the IC 50 value, the Ki can be calculated using the following formula: Ki = IC50/(l + [Substrate]/Km).



This data clearly shows that compounds of the present invention exhibit tryptase inhibition activity. Consequently, compounds of the present invention readily have applications in pharmaceutical compositions for treating a wide variety of tryptase related conditions, and naturally, in methods for treating such conditions in patients.
The present invention is not to be limited in scope by the specific embodiments describe herein. Indeed, various modifications of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing description and the accompanying figures. Such modifications are intended to fall within the scope of the appended claims.
Various publications are cited herein, the disclosures of which are incorporated by reference in their entireties.







WE CLAIM:

is a single or a double bond;
R and R are each independently hydrogen or lower alkyl;
R3 is aryl, arylalkenyl, cycloalkenyl, cycloalkyl, heteroaryl, heteroarylalkenyl, heterocycloalkenyl, a carbon linked heterocycloalkyl or alkyl optionally substituted by one or more groups selected from hydroxy, alkoxy, alkyloxycarbonylamino, cycloalkyl, heterocycloalkyl, R6 -O R6 -S(0)ni R6 or-C(=0)- R6
R is hydrogen, acyl, alkoxy, alkyloxycarbonyl, carboxy, cyano, halo, hydroxy,
-C(=0)-NY1Y2 or alkyl optionally substituted with alkoxy, alkylcarbonylamino, alkylsulfonylamino, hydroxy, -S(0)m-alkyl or-NY1 Y2;
R6 is aryl or heteroaryl;
Y and Y are each independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl or heterocycloalkyl; or the group -N Y Y may form a cyclic amine;

m is zero or an integer 1 to 2; and
n is zero or an integer 1 to 4; or
an N-oxide of said compound, a pharmaceutically acceptable salt of said compound,
or a hydrate of said compound.
2. The compound as claimed in Claim 1, wherein R1 or R2 is hydrogen; and R3 is aryl or heteroaryl.
3. The compound as claimed in Claim 2, wherein R3 as aryl is phenyl or naphthyl,
4. The compound as claimed in Claim 2, wherein said R3 as aryl is substituted with at least one substituent.
5. The compound as claimed in Claim 4, wherein said substituent is selected from the group consisting of halo, alkyl substituted by aryl, alkyl substituted by aryloxy, alkyl substituted by aroyl, alkyl substituted by heteroaryl, arylalkynyl, heteroarylalkynyl, aryl, heteroaryl, arylalkenyl and arylalkyloxy.
6. The compound as claimed in Claim 5, wherein said aryl or heteroaryl of said substituent is further substituted by at least one aryl group substituent.
1, The compound as claimed in Claim 2, wherein said heteroaryl is pyridyl, quinolinyl, thienyl, furanyl, or indolyl.
8. The compound as claimed in Claim 7, wherein said heteroaryl is substituted with at least one substituent.

9. The compound as claimed in Claim 8, wherein said substituent is alkyl, alkyl substituted by aryl, alkyl substituted by aryloxy, alkyl substituted by aroyl, alkyl substituted heteroaryl, arylalkynyl, heteroarylalkynyl, heteroaryl, arylalkenyl or arylalkyoxy.
10. The compound as claimed in Claim 9, wherein said aryl of said substituent is further substituted by at least one aryl substituent.
11. The compound as claimed in Claim 1, wherein is a single bond.
12. The compound as claimed in Claim 1, wherein n is 2.
13. The compound as claimed in Claim 1, wherein:
Ar is phenyl;
R and R are both hydrogen;
R3 is aryl, naphthyl or heteroaryl;
R4 is hydrogen or a cyano;
is a single bond; and
n is 2.
14. The compound as claimed in Claim 13 wherein said aryl or said naphthyl of R3 is substituted with at least one substituent comprising halo, alkyl substituted by aryl, alkyl substituted by aryloxy, alkyl substituted by aroyl, alkyl substituted by aryloxy, alkyl substituted by aroyl, alkyl substituted by heteroaryl, arylalkynyl, heteroarylalkynyl, aryl, heteroaryl, arylalkenyl, or arylalkyloxy.
15. The compound as claimed in Claim 14, wherein said aryl or said heteroaryl of said substituent is further substituted by at least one aryl substituent.

16. The compound as claimed in Claim 13, wherein said heteroaryl of R^ is
substituted by at least one substituent comprising pyridyl, quinolinyl, thienyl, furanyl,
or indolyl.
17. The compound as claimed in Claim 16, wherein said substituent of said
heteroaryl is further substituted by at least one moiety comprising alkyl substituted by
aryl, alkyl substituted by aryloxy, alkyl substituted by aroyl, alkyl substituted
heteroaryl, arylalkynyl, heteroarylalkynyl, heteroaryl, arylalkenyl, or arylalkyloxy.
18. The compound as claimed in Claim 17, wherein an aryl of said moiety is
further substituted by at least one aryl substituent.

R' and R^ are each independently hydrogen or lower alkyl;
R3 is aryl, arylalkenyl, cycloalkenyl, cycloalkyl, heteroaryl, heteroarylalkenyl, heterocycloalkenyl, a carbon linked heterocycloalkyl or alkyl optionally substituted by one or more groups selected from hydroxy, alkoxy, alkyloxycarbonylamino,


m is zero or an integer 1 to 2; and
n is zero or an integer 1 to 4; or
a corresponding N-oxide of said compound, a prodrug of said compound, a
pharmaceuticaliy acceptable salt of said compound, a solvate of said compound, an N-
oxide of said solvate of said compound, or a prodrug of said solvate of said
compound.


21. The compound as claimed in Claim 19 or 20, wherein R^ is aryl comprising
phenyl or naphthyl.
22. The compound as claimed in Claim 21, wherein said aryl is substituted by at
least one substituent comprising halo, alkyl substituted by aryl, alkyl substituted by
heteroaryl.
23. The compound as claimed in Claim 22, wherein said aryl or heteroaryl of said
substituent is further substituted by at least one aryl group substituent.
24. The compound as claimed in Claim 19 or 20, wherein R is heteroaryl comprising pyridyl, quinolinyl, thienyl, furanyl, or indolyl.
25. The compound as claimed in Claim 24, wherein said heteroaryl is substituted by at least one substituent comprising alkyl substituted by aryl, or alkyl substituted by heteroaryl.
26. The compound as claimed in Claim 25, wherein said aryl and said heteroaryl of said substituent are further substituted by at least one aryl group substituent.

27. The compound as claimed in Claim 19 or 20, wherein R-* comprises phenylCi_3alkylpyridyl, phenylCi_3alkylthienyl, or indolyl.
28. The compound as claimed in Claim 1, 19 or 20, wherein R4 comprises a hydrogen or a cyano.
29. The compound as claimed in Claim 19 or 20, wherein R5 comprises hydrogen, lower alkyl or halo.
30. The compound as claimed in Claim 29, wherein R5 comprises methyl or fluoro.
31. The compound as Claimed in Claim 29, wherein R5 is attached to the phenyl at the position para to the CH2NH2.
32. The compound as claimed in Claim 19 or 20, wherein;
R is a phenyl, a naphthyl, a heteroaryl selected from the group consisting pyridyl, quinolinyl, thienyl, furanyl, and indolyl, a phenyl substituted by at least one substituent, a naphthyl substituted by at least one substituent, or a heteroaryl selected from the group consisting pyridyl, quinolinyl, thienyl, furanyl, and indolyl, that is substituted by at least one substituent, wherein said substituent is selected from the group consisting of halo, alkyl substituted by aryl, and alkyl substituted heteroaryl, wherein the aryl or heteroaryl are further substituted by one or more aryl group substituents;
R4 is hydrogen or a cyano; and
R5 is hydrogen, lower alkyl or halo.
33. The compound as claimed in Claim 32, wherein:
R3 is phenylC1-3alkylpyridyl, phenylC1-3alkyIthienyi, or indolyl;
R4 is hydrogen or cyano; and

R5 is methyl or fluoro, and is attached to the phenyl at the position para to the CH2NH2.
34. The compound as claimed in Claim 27, wherein the phenylC1-3alkylpyridyl is 5-phenylethyl-pyrid-3-yl, the phenyiC1-3alkylthienyl is 5-phenyIethyI-thien-2-yl and the indolyi is indol-6-yl.
35. A compound selected from the group consisting of: 3-[l-(5-phenylethynyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine; 3-[l-(3-phenylethyl-benzoyl)-piperidin-4-yl]-benzylamine; 3-{l-[3-(4-hydroxyphenyl)ethyl-benzoyl]-piperidin-4-yl}-benzylamine; 3-{l-[3-(6-aminO'pyridin-3-yl)ethyl'benzoyl]-piperidin-4-yl}-benzylamine; 3-[l-(5-phenylethyl'thiophene-2-carbonyl)-piperidin-4-yl]-benzylamine; 4-fluoro-3-[l-(5-phenylethyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine; 4-methyl-3-[l-(5-phenylethyl-pyridine-3-Carbonyl)-piperidin-4-yl]-benzylamine; 3-[l-(indole-6-carbonyl)-piperidin-4-yl]-benzylamine;
4-(3-aminomethyl-phenyl)-l-(5-phenethyl-pyridine-3-carbonyl)-piperidine-4-carbonitrile
[4-(3-aminomethylphenyI)piperidin-l-yl]-(3,4-dichlorophenyl)methanone; l-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-methylsulfanyl-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(3-methylsuIfanyl-6,7-dihydro-benzo[c]thiophen-1 -yl)-methanone trifluoroacetate;
l-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-ethylsulfanyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate; l-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-propylsuIfanyI-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate;
l-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-isopropylsulfany]-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate;

1 -[4-(3-Aminomethyl-phenyl)-piperidin-l -yI]-1 -benzo[b]thiophen-2-yl-methanone-
trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-4-hydroxy-piperidin-l-yl]-l-(5-phenethyI-pyridin-3-
yl)-methanone-ditrifluoroacetate;
1 -[4-(3-Aminomethyl'phenyl)-piperidin-1 -yl]-1 -(1 -methyl-1 H-indol-3 -yl)-methanone-
trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-[3-(2-fluoro-phenylethynyl)-phenyl]-
methanone trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-{3-[2-(2-fluoro-phenyI)-ethyl]-
phenyl} -methanone trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yi]-l-{3-[2-(6-amino-pyridin-3-y{)-ethyl]-
phenyl} -methanone tri-trifluoroacetate;
l-[4-(3-Aminomethyl-phenyI)-piperidin-l-yl]-l-(6-chIoro-thieno[3,2-i]thiophen-2-
yl)-methanone trifluoroacetate;
(3R,4S) and (3S, 4R)-4-(3-Aminomethyl-phenyl>l-(5-phenethyl-pyridine-3-
carbonyl)-piperidine-3-carboxylic acid ethyl ester dihydrochloride;
3-[l-(5-Phenylethynyl-furan-2-carbonyl)-piperidin-4-yi]-benzyiamine trifluoroacetate;
4-(3-Aminomethyl-phenyl)-piperidine-l -carboxylic acid (3,4-dichloro-phenyl)-amide
trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(2,3-dihydro-ben2ofuran-5-yl)-
methanone;
1 -[4-(3-Aminomethyl-phenyi)-piperidin-1 -yl]-1 -(5,6-dichIoro-pyridin-3-yl)-
methanone;
l-[4-(3-AminomethyI-phenyl)-piperidin-l-yI]-l-(3-bromo-4-fluoro-phenyl)-
methanone;
(E)-l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-3-(2-nitro-phenyl)-propenone;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(3-bromo-5-iodo-phenyl)-methanone;
and (E)-l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-3-phenyUpropenone.

36. A pharmaceutical composition comprising a compound as claimed in Claim 1 or 35 and a pharmaceutically acceptable carrier thereof.
37 The pharmaceutical composition as claimed in Claim 36, wherein said
compound is selected from the group consisting of:
3-[l-(5-phenyIethynyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine;
3-[l-(3-phenylethyl-benzoyl)-piperidin-4-yl]-benzylamine;
3-{l-[3-(4-hydroxyphenyl)ethyl-benzoyl]-piperidin-4-yl}-benzylamine;
3-{l-[3-(6-amino-pyridin-3-yl)ethyl-benzoyl]-piperidin-4-yl}-benzylamine;
3-[l-(5-phenylethyl-thiophene-2-carbonyl)-piperidin-4-yl]-benzylamine;
4-fluoro-3-[l-(5-phenylethyl-pyridine-3-carbonyl)-piperidin-4-yl]'benzylamine;
4-methyI-3-[l-(5-phenylethyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzylamine;
3'-[l-(indole-6-carbonyl)-piperidin'4-yl]-benzylamine;
4-(3-aminomethyl-phenyl)-l-(5-phenethyl-pyridine-3-carbonyl)-piperidine-4-
carbonitrile
[4-(3-aminomethylphenyl)piperidin-l-yl]-(3,4-dichlorophenyl)methanone;
l-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-methylsuIfanyl-6,7-
dihydro-5H-benzo[c]thiophen-4-One trifluoroacetate;
1 -[4-(3-Aminomethyl-phenyl)-piperidin-l -yl]-l -(3-methylsulfanyl-6,7-dihydro-
benzo[c]thiophen-1 -yl)-methanone trifluoroacetate;
1 - {1 -[4-(3-Aminomethyl-phenyl)-piperidin-1 -yl]-methanoyl} -3-ethylsulfanyl-6,6-
dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate;
l-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-propylsulfanyl-6,7-
dihydro-5H-benzo[c]thiophen-4-one trifluoroacetate;
l-{l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-methanoyl}-3-isopropylsulfanyl-
6,7-dihydro-5H-benzo[c]thiophen-4-One trifluoroacetate;
1 -[4-(3-Aminomethyl-phenyl)-piperidin-1 -yl]-1 -benzo[b]thiophen-2-yl-methanone-
trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-4-hydroxy-piperidin-l-yl]-l-(5-phenethyl-pyridin-3-
yl)-methanone-ditrifluoroacetate;

1 -[4-(3-Aminomethy l-phenyl)-piperidin-1-yl]-1-(1-methyl-1 H-indol-3-yl)-meth^
trifluoroacetate;
l-[4-(3-Aminomethyl-phenyI)-piperidin-l-yl]-l'[3-(2-fluoro-phenylethynyl)-phenyl]-
methanone trifluoroacetate;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-{3-[2-(2-fluoro-phenyl)'ethyl]-
phenyl}-methanone trifluoroacetate;
l-[4'(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-{3-[2-(6-aminO-pyridin-3-yl)'ethyl]-
phenyl}-methanone tri-trifluoroacetate;
1 -[4-(3-Aminomethyl-phenyl)-piperidin-l -yl]-l -(6-chloro-thieno[3,2-/?]thiophen-2-
yl)-methanone trifluoroacetate;
(3R,4S) and (3S, 4R)-4-(3-Aminomethyl-phenyl)-l-(5-phenethyl-pyridine-3-
carbonyl)-piperidine-3-carboxylic acid ethyl ester dihydrochloride;
3-[]-(5-PhenyIethynyl-furan-2-carbonyl)-piperidin-4-yl]-benzylamine trifluoroacetate;
4-(3-Aminomethyl-phenyl)-piperidine-l-carboxylic acid (3,4-dichloro-phenyl)-amide
trifluoroacetate;
l-[4'(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(2,3-dihydro-benzofuran-5-yl)-
methanone;
l-[4-(3-Aminomethyl-phenyl)'piperidin-l-yl]-l-(5,6-dichloro-pyridin-3-yI)-
methanone;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(3-bromo-4-fluoro-phenyl)-
methanone;
(E)-I-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-3-(2-nitro-phenyl)-propenone;
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-l-(3-bromo-5-iodo-phenyl)-methanone;
(E)-l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-3-phenyl-propenone; and
l-[4-(3-Aminomethyl-phenyl)-piperidin-l-yl]-3-cyclohexyl-propan-l-one,
38. A pharmaceutical composition comprising a compound as claimed in Claim 19 or 20 and a pharmaceutically acceptable carrier thereof

39, A pharmaceutical composition comprising a compound as claimed in Claim 1,
19, 20 or 35 and a second compound selected from the group consisting of beta
andrenergic agonist, anticholinergic, anti-inflammatory corticosteroid, and anti¬
inflammatory agent; and a pharmaceutically acceptable carrier thereof.
40. The pharmaceutical composition as claimed in Claim 39, wherein the beta
andrenergic agonist comprises albuterol, terbutaline, formoterol, fenoterol or
prenaline;
the anticholinergic comprises ipratropium bromide;
the anti-inflammatory corticosteroid comprises beclomethasone dipropionate,
triamcinolone acetonide, flunisolide or dexamethasone; and
the anti-inflammatory agent comprises sodium cromoglycate or nedocromil sodium.


Documents:

in-pct-2002-1892-che-abstract.pdf

in-pct-2002-1892-che-claims filed.pdf

in-pct-2002-1892-che-claims granted.pdf

in-pct-2002-1892-che-correspondnece-others.pdf

in-pct-2002-1892-che-correspondnece-po.pdf

in-pct-2002-1892-che-description(complete)filed.pdf

in-pct-2002-1892-che-description(complete)granted.pdf

in-pct-2002-1892-che-form 1.pdf

in-pct-2002-1892-che-form 26.pdf

in-pct-2002-1892-che-form 3.pdf

in-pct-2002-1892-che-form 5.pdf

in-pct-2002-1892-che-other documents.pdf

in-pct-2002-1892-che-pct.pdf


Patent Number 213115
Indian Patent Application Number IN/PCT/2002/1892/CHE
PG Journal Number 13/2008
Publication Date 28-Mar-2008
Grant Date 20-Dec-2007
Date of Filing 20-Nov-2002
Name of Patentee AVENTIS PHARMACEUTICALS INC
Applicant Address Route 202-206 P.O. Box 6800 Bridgewater, NJ 08807
Inventors:
# Inventor's Name Inventor's Address
1 ASTLES, Peter, C (ET. AL) The Flour Store The Mill House Chevening Road Chipstead Sevenoaks, Kent TN13 2RY,
PCT International Classification Number C07D 211/26
PCT International Application Number PCT/US2001/013811
PCT International Filing date 2001-04-27
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 09/843, 126 2001-04-26 U.S.A.
2 0012362.0 2000-05-22 U.S.A.