Title of Invention

PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS

Abstract Process for preparing compounds of the formula (I) in which R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group, which may be substituted by alkyl, or a trimethylene group, which may be substituted by alkyl, X represents an oxygen or sulphur atom or the group in which R3 represents a hydrogen atom or an alkyl group, and Z represents an optionally substituted 5- or 6-membered heterocyclic group which contains at least two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, or denotes an optionally substituted 3- or 4-pyridyl group, characterized in that compounds of the formula (II) in which A and X are each as defined above are reacted with compounds of the formula (III) in which R1 and Z are each as defined above and M1 denotes a halogen atom or the group -OSO2-M2, in which M2 denotes a C1-C6-alkyl group, an aryl group or OM3, where M3 denotes a C1-C6-alkyl group or an alkali metal, in the presence of an alcohol which is not or is only partly water-miscible and is selected from the group comprising iso-butanol, n-butanol and amyl alcohol, and, if appropriate, in the presence of a base.
Full Text FORM 2
THE PATENTS ACT 1970
[39 OF 1970]
COMPLETE SPECIFICATION
[See Section 10]
"PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS"

BAYER AKTIENGESELLSCHAFT, a body corporate organised under the laws of Germany, of D-51368 Leverkusen, Germany,
The following specification particularly describes the nature of the invention and the manner in which it is to be performed:-


Process for preparing heterocyclic compounds
The present invention relates to a novel process for preparing known heterocyclic compounds by alkylation of suitable precursors. 5
Such alkylation reactions in aprotic solvents are known (EP A2 0235 725).
Also known is the preparation of unsaturated heterocyclic compounds by alkylating
unsubstituted ring nitrogen atoms which can be carried out, inter alia, in alcohols
10 (EP A2 0 259 738).
In these instances, a subsequent purification of the product is required to achieve a sufficient purity; moreover, the yields that can be obtained with the known processes are unsatisfactory. 15
It has now been found that compounds of the formula (I)

in which 20
R1 represents a hydrogen atom or an alkyl group,
A represents an ethylene group, which may be substituted by alkyl, or a tri-methylene group, which may be substituted by alkyl, 25
X represents an oxygen or sulphur atom or the group


in which
R3 represents a hydrogen atom or an alkyl group, and 5
Z represents an optionally substituted 5- or 6-membered heterocyclic group
which contains at least two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, or denotes an optionally substituted 3- or 4-pyridyl group, 10
are obtained when compounds of the formula (II)

in which 15
A and X are each as defined above
are reacted with compounds of the formula (III)
20
in which
R1 and Z are each as defined above and
25 M1 represents a halogen atom or the group -OSO2-M2,
in which

M2 denotes a lower alkyl group, an aryl group or OM3,
where
5
M3 denotes a lower alkyl group or an alkali metal,
in the presence of a protic solvent and, if appropriate, in the presence of a base, followed by crystallization from an alcohol. 10
The process according to the invention avoids the purification step of recrystal-lization which has hitherto been necessary and requires one operation less than the processes of the prior art.
15 Surprisingly, the yields obtained in the process according to the invention are
considerably higher than the yields that can be obtained in the processes of the prior art.
Although in the process according to the invention the reaction of the compounds
20 (III) and (II) is carried out in protic solvents, contrary to expectations an ether
formation according to Williamson (see textbooks of organic chemistry) is not observed.
In the general formulae I, II and III, 25
R1 preferably represents hydrogen or a C1-C3-alkyl group, particularly preferably hydrogen;
A preferably represents an ethylene or trimethylene group, which may in each
30 case be substituted by a C1C3-alkyl group, particularly preferably an ethylene
group;

X preferably represents an oxygen or sulphur atom, particularly preferably, a sulphur atom;
5 Z preferably represents a halogenated 5- or 6-membered heterocyclic group
which contains 2 heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen or represents a halogenated 3- or 4-pyridyl group, particularly preferably a halogenated thiazolyl or 3-pyridyl group, very particularly preferably 2-chloro-pyrid-5-yl; 10
M preferably represents C1, Br, tosyl or OS02OK, particularly preferably CI or Br.
A very particularly preferred compound of the formula (I) is the compound of the
15 formula (la)

which is obtained by reacting the compound of the formula 20

with the compound of the formula


In connection with alkyl, alkoxy, alkylthio or alkylsilyl groups, the term "lower" represents C1-C6-, preferably C1-C4-, alkyl, -alkoxy, -alkylthio or -alkylsilyl groups. 5
Particularly suitable polar protic solvents are water and alcohols or mixtures of water and alcohols. If the solvent used is an alcohol, which is preferred, the compounds of the formula (I) can be obtained directly in a modification that is advantageous for use as crop protection agents, and in the purity required. 10
Examples of alcohols which may be mentioned are:
primary alcohols, such as methanol, ethanol, propanol, butanol, 2-methyl-l-propanol, 1-pentanol, benzyl alcohol, 15
secondary alcohols, such as isopropanol, sec-butanol, 2-pentanol, tert-alcohols, such as tert-butanol.
Particularly preferred solvents are alcohols which are not or are only partly water-
20 miscible, such as iso-butanol or n-butanol or amyl alcohol, in particular n-butanol.
The process is, if appropriate, carried out in the presence of a base. Examples which
may be mentioned are: alkali metal hydroxides and alkaline earth metal hydroxides,
such as NaOH, KOH, Ca(OH)2, alkali metal carbonates or bicarbonates, such as
25 Na2C03, Li2C03, K2C03, Cs2C03 or NaHC03 and KHC03. K2C03, NaOH and
KHC03, in particular K2C03, may be mentioned as being preferred.
The compounds of the general formula II can also be employed as alkali metal or alkaline earth metal salts, in solid or dissolved form.

Le A 33 457-Foreign Countries
If the reaction is carried out in water or water/alcohol mixtures, the process is carried out in a pH range between 8 and 13.
5 The catalysts used can be phase-transfer catalysts, if appropriate quaternary
ammonium halides, such as tetrabutylammonium chloride etc.
The process can be carried out in a broad temperature range, for example between
30°C and 100°C, preferably between 50°C and 80°C. The reaction is advantageously
10 carried out under atmospheric pressure; however, it can also be carried out under
reduced or elevated pressure.
When carrying out the process in practice, for example 1 mol of the compounds of
the formula (II) is reacted with from 1 to 1.3 mol, preferably from 1 to about 1.1 mol,
15 of the compounds of the formula (III) at pH 8 - 9 in a polar solvent, such as butanol,
in the presence of from 0.6 to 2 mol, preferably from 1 to 1.3 mol, of a base, such as potassium carbonate, and if appropriate in the presence of a catalyst, such as tetrabutylammonium chloride.
20 The reaction can also be carried out by initially charging the compounds of the
general formula II as alkali metal salt or alkaline earth metal salt, in dissolved or suspended form, and metering in the compounds of the general formula III at reaction temperature.
25 The compounds of the formulae (II) and (III) are known from EP 0 235 725 (and the
literature cited therein).
The compounds of the formula (I) are suitable, for example, for use as insecticides (EP A2 0235 752, EP A2 0259 738).

Accordingly the present invention relates to a process for preparing compounds of the formula (I)

in which
R1 represents a hydrogen atom or an alkyl group,
A represents an ethylene group, which may be substituted by alkyl, or a
trimethylene group, which may be substituted by alkyl,
X represents an oxygen or sulphur atom or the group

in which
R3 represents a hydrogen atom or an alkyl group, and
Z represents an optionally substituted 5- or 6-membered heterocyclic group
which contains at least two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, or denotes an optionally substituted 3- or 4-pyridyl group,
characterized in that compounds of the formula (II)


in which
A and X are each as defined above
are reacted with compounds of the formula (III)

in which
R1 and Z are each as defined above and
M1 denotes a halogen atom or the group -OSO2-M2,
in which
M2 denotes a Ci-C6-alkyl group, an aryl group or OM3, where
M3 denotes a Ci-C6-alkyl group or an alkali metal,
in the presence of an alcohol which is not or is only partly water-miscible and is selected from the group comprising iso-butanol, n-butanol and amyl alcohol, and, if appropriate, in the presence of a base.
The examples below illustrate the subject-matter of the invention, without limiting it in any way.

Example 1

5
0.3 mol of 2-cyanoiminothiazolidine and 0.315 mol of 2-chloro-5-chloro-methyl-
pyridine are dissolved in 240 g of n-butanol, and the solution is heated to 80°C. At
this temperature, 0.36 mol of potassium carbonate are metered in, and the mixture is
stirred at 80°C for 2 h. After cooling (to 65°C), 250 g of water are added and the
10 phases are separated. The organic phase is then stirred at 50°C for 3 h and
subsequently cooled to 3°C over a period of 3 h. Precipitated product is filtered off and dried; 62.3 g (83% of theory). M.p.: 135°C.
Example 2
15
0.3 mol of 2-cyanoiminothiazolidine and 0.315 mol of 2-chloro-5-chloro-methyl-pyridine and 0.015 mol of tetrabutylammonium bromide are suspended in water, and the suspension is heated to 60°C. The pH of the reaction mixture is continuously maintained at from 8 to 8.5, using NaOH. After a reaction time of 2 h at 60°C, the
20 phases are separated at this temperature and the organic phase is diluted with 200 ml
of butanol and stirred at 50°C for 3 h. Over a period of 3 h, the mixture is cooled to 3°C, and precipitated product is fiheTed off with suction; this gives 55.5 g (72% of theory).

Example 3
39.3 g of 97% strength 2-cyanoimino-thiazolidine 0.3 mol) are taken up in 250 g
5 of 80% strength n-butanol (containing 20% of H20) and admixed with 26.7 g of 45%
strength aqueous sodium hydroxide solution (0.3 mol). This gives a pale-green
solution which, at 65°C, is admixed with 49.5 g of 95%) strength 2-chloro-5-
chloromethylpyridine (0.29 mol). After a reaction time of 3.5 h, 190 g of water are
added and the phases are separated. About 60 g of n-butanol/water are distilled off
10 from the organic phase. The organic phase is then cooled to 50°C, seed crystals are
added and cooling is continued to 0°C. At this temperature, the mixture is crystallized with stirring for 3 h. Filtration and drying give 61.8 g of 96% pure product (87% of theory).

WE CLAIM:
1. Process for preparing compounds of the formula (I)

in which
R1 represents a hydrogen atom or an alkyl group,
A represents an ethylene group, which may be substituted by alkyl, or a trimethylene group, which may be substituted by alkyl,
X represents an oxygen or sulphur atom or the group

in which
R3 represents a hydrogen atom or an alkyl group, and
Z represents an optionally substituted 5- or 6-membered heterocyclic group which contains at least two heteroatoms selected from the group

consisting of oxygen, sulphur and nitrogen atoms, or denotes an optionally substituted 3- or 4-pyridyl group,
characterized in that compounds of the formula (II)

in which
A and X are each as defined above
are reacted with compounds of the formula (III)

in which
R1 and Z are each as defined above and
M1 denotes a halogen atom or the group -OSO2-M2,
in which
M2 denotes a C1-C6-alkyl group, an aryl group or OM3,

where
M3 denotes a C1-C6-alkyl group or an alkali metal,
in the presence of an alcohol which is not or is only partly water-miscible and is selected from the group comprising iso-butanol, n-butanol and amyl alcohol, and, if appropriate, in the presence of a base.
2. Process as claimed in claim 1, wherein compounds of the formula
(III) are used in which
Z represents a halogenated thiazolyl or 3-pyridyl group.
3. Process as claimed in claim 1, wherein compounds of the formula
(III), wherein
A represents an ethylene or trimethylene group, each of which may be substituted by a C1-C3-alkyl group,
X represents an oxygen or sulphur atom,
are reacted with compounds of the formula (III) in which
R1 represents hydrogen or a C1-C3-alkyl group,
Z represents a halogenated thiazolyl or 3-pyridyl group,
M' represents C1 Br, tosyl or -OSO2OK.
4. Process as claimed in claim 1, wherein the compound of the
formula (la)


is obtained when the compound of the formula (Ha)

is reacted with the compound of the formula (IIIa)

in the presence of an alcohol which is not or is only partly water-miscible and is selected from the group comprising iso-butanol, n-butanol and amyl alcohol, and, if appropriate, in the presence of a base.
5. Process as claimed in claim 4, wherein n-butanol is used.
6. Process for preparing compounds substantially as hereinbefore described with reference to the foregoing examples.
Dated this January 12, 2000.
(DR. ANUSHRI GUPTA)
OF REMFRY AND SAGAR ATTORNEY FOR THE APPLICANTS

Documents:

37-mum-2000-claims(granted)-(20-08-2007).doc

37-mum-2000-claims(granted)-(20-08-2007).pdf

37-mum-2000-correspondence(18-09-2007).pdf

37-mum-2000-correspondence(ipo)-(30-07-2007).pdf

37-mum-2000-form 1(12-01-2000).pdf

37-mum-2000-form 13(20-08-2007).pdf

37-mum-2000-form 13(29-05-2006).pdf

37-mum-2000-form 18(15-12-2005).pdf

37-mum-2000-form 18(15-12-2006).pdf

37-mum-2000-form 2(granted)-(20-08-2007).doc

37-mum-2000-form 2(granted)-(20-08-2007).pdf

37-mum-2000-form 3(07-03-2007).pdf

37-mum-2000-form 3(07-04-2000).pdf

37-mum-2000-form 3(12-01-2000).pdf

37-mum-2000-form 5(12-01-2000).pdf

37-mum-2000-petition under rule 138(07-03-2007).pdf

37-mum-2000-power of authority(17-10-2002).pdf

37-mum-2000-power of authority(20-08-2007).pdf

37-mum-2000-power of authority(29-06-2007).pdf


Patent Number 211270
Indian Patent Application Number 37/MUM/2000
PG Journal Number 43/2008
Publication Date 24-Oct-2008
Grant Date 24-Oct-2007
Date of Filing 12-Jan-2000
Name of Patentee BAYER AKTIENGESELLSCHAFT
Applicant Address D-51368 LEVERKUSEN,
Inventors:
# Inventor's Name Inventor's Address
1 HERMANN SEIFERT BIRKENWEG 3, 51467 BERGISCH GLADBACH,
2 REINHARD LANTZSCH AM BUSCHHAUSCHEN 51, 42115 WUPPERTAL,
3 WERNER LINDNER MARCHENSTR. 39, 51067 KOLN,
4 KLAUS JELICH PAUL-EHRILICH-STR. 2, 42113 WUPPERTAL,
PCT International Classification Number C07D417/06
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 19904310.8 1999-01-28 Germany