Title of Invention

METHOD OF PREPARATION OF DRY POWDER FILM COATING COMPOSITION

Abstract A method of making a dry powder film forming composition capable of forming an aqueous solution having a low viscosity ranging from 75 to 150 cps for use on pharmaceutical tablets, food, and confectionary products, comprising the steps of: mixing a dry^powdered cellulosic polymer, a film forming amount of gum acacia, and a plasticizer in a blender until thoroughly dry mixed form an edible film forming composition wherein said composition does not contain added water prior to being put into solution for application on said pharmaceutical tablets, food and confectionery products.
Full Text
FORM 2
THE PATENTS ACT 1970
(39 of 1970)
&
THE PATENTS RULES, 2003
COMPLETE SPECIFICATION
(See Section 10; rule 13)

TITLE
METHOD OF PREPARATION OF DRY POWDER FILM COATING
COMPOSITION
APPLICANTS
CHR. HANSEN, INC. of 9015 West Maple Street, Milwaukee, Wisconsin 53214, U.S.A, American Company
GRANTED
29-3-2005
The following complete specification particularly describes the nature of the invention and the manner in which it is to be performed.



1

Field of the Invention
This invention relates generally to method for preparation of an edible dry-powder film coating composition for use on pharmaceutical, food, and confectionaries.
Background of the Invention
Cellulose polymers such as hydroxypropyl methylcellulose ("HPMC") have long been recognized in the art as suitable aqueous film coatings for pharmaceuticals tablets and the like. While it is common to use HPMC (and other similar polymers), it can be rather expensive. The available alternative for a non-enteric coating is a sugar coating. Though a sugar coating can be less expensive, can prevent moisture migration into the tablet substrate and can mask bad flavours, it is not desirable as a film coating for all uses. For example, sugar coatings cannot be applied as thinly as a film coating, are not clear, and are not non-caloric. Furthermore, sugar coatings have a higher risk of cracking than do film coatings. Finally, sugar coatings are typically mixed with hot water prior to application, which is not always readily available.
Manufacturers faced with the need to provide a durable, virtually non-caloric, thin or clear coat on tablets or confectionaries must pay a relatively high amount per pound for HPMC, or live with the drawbacks of sugar coatings.
U.S. Patent No 5,591,455 to Signorino suggests using gum acacia, instead of or in addition to other ingredients, in combination with HPMC to make a "wet-powder" blend for aqueous film coating. Water and plasticizers are added
2

to the wet-powder blend prior to application. However, there is no disclosure of
the amount of gum acacia that is effective. This failure is critical since gum
acacia has not previously been used as a film-former, and would not ordinarily be
expected to be used as a film former. This is because gum acacia is traditionally
5 used as a wetting agent, emulsifier or binder - applications that are markedly
different from those in which film formers are generally used. Moreover, wet
powder products, such as that disclosed in the Signorino patent, contains up to
30% water resulting in a heavier product that is significantly more costly to ship.
In addition, the added moisture often negatively affects the shelf life of the
10 blended ingredients (e.g., wet gum acacia can readily become moldy).
U.S. Patent No. 5,470,581 to Grillo et al. discloses a dry-powder edible
film-coating composition for use on pharmaceuticals and the like, comprising a
dry mixture of a cellulosic polymer, maltodextrin and a plasticizer. The
maltodextrin is used in quantities ranging from 5% to 78.5% by weight of the
15 powder. Though maltodextrin is a film former that costs less than those generaily
used, i.e. hydroxypropyl methylcellulose, it does not perform as well because it yields a brittle coating that is prone to cracking.
Futhermore, U.S. Patent No. 4,453,370 to Porter et al. discloses another
dry-powder edible film-coating composition for use on pharmaceuticals and the
20 like, comprising in part of powdered particles of a film forming non-toxic edible
polymer and a pigment. However, the resulting film coating is not clear.
Therefore, there remains a need for a less-expensive, dry-powder film coating for pharmaceuticals and confectionaries that is clear and performs as well as a coating containing more expensive components.
3

SUMMARY OF THE INVENTION
Therefore, it is aa object of the present invention to provide a film coating
for pharmaceuticals and confectionaries that costs less that presently available
film coatings.
5 It is a further object of the present invention to provide a film coating for
pharmaceuticals and confectionaries that is durable.
It is yet another object of the present invention to provide a film coating
for pharmaceuticals and confectionaries that does not contain added water prior
to being put into solution for application to a substrate.
10 It is still another object of the present invention to provide a film coating
for pharmaceuticals and confectionaries that is clear, shiny, and has defined logo resolution.
It is a still further object of the present invention to provide a film coating
for pharmaceuticals and confectionaries that is easy to apply, and does not require
15 mixing with hot water prior to application.
These objects, and other aspects and advantages of the present invention
are achieved by using gum acacia as a film former in addition to a cellulosic film
former such as hydroxypropyl methylcellulose and a plasticizer such as
propylene glycol in a dry powder form.
20 Gum acacia (Acacia seyal) has been used commercially in the United
States since the late 1980's, and is also available as gum arabic, kordofan gum, Senegal gum, Indian gum, and cape gum. Prior to this time, the significant use of gum acacia occurred in India in a raw state as a confection. Subsequent to the approval of gum acacia as a pharmaceutical ingredient by the FDA, its use and
4

importance has increased significantly. However, gum acacia is traditionally
used as a wetting or thickening agent, as an emulsiiier, or as a binder.
Specifically, gum acacia has been used for compounding pills, lozenges,
mixtures, and emulsions; and for administering insoluble substances in water, as
5 oils, resins, balsams, camphor, musk, etc. Though gum acacia does not
deteriorate if kept dry, if put into solution (i.e. a concentrated mucilage) it will
sour after an extended period. Hot water hastens this fermentation, if employed
in making a mucilage or the like. Further, dilute solutions of the gum become
moldy.
10 In one embodiment of the present invention, the cellulosic polymer is
added to the composition in a range of about zero percent (0 %) to about ninety
percent (90 %) by weight of the composition, the gum acacia is added to the
composition in a range of about five percent (5 %) to about ninety percent (90 %)
by weight of the composition, and the plasticizer is added to the composition in a
15 range of about zero percent (0 %) to about fifteen percent (15 %) by weight of the
composition.
Other embodiments of the present invention include a detackifier such as talc or magnesium stearatc.
In a method in accordance with the present invention, a dry powder film
20 forming composition is made by mixing dry ingredients gum acacia, a cellulosic
polymer, and a plasticizer in a blender until thoroughly mixed. Then, just prior to use, the dry powder can be put into solution by bringing about one-half the required amount of water to boiling, adding the dry powder of the present invention under agitation, and bringing the solution to a desired concentration by
5

adding cold water. The solution is stirred until completely dissolved, and the solution brought to a temperature of about 23°C. The solution is measured until a flash point of 93.3°C (200°F) is obtained.
The present invention offers two substantial benefits over the prior art.
5 First, the present invention offers a reduction in cost in excess of 10% when
compared to the widely used pigmented coating systems. Second, the present
invention offers the flexibility of either providing a pigmented or clear coat. In
addition, the composition in the present invention is able to offer: (1) rapid
dissolution in water; (2) minimum generation of foam; (3) superior film quality;
10 (4) good substrate adhesion including edges and logos; (5) defined logo
resolution; (6) translucent film with brilliant shine; (7) ideal tensile strength and
elasticity; (7) simplified coating formulation; and (8) ease of application. Many
traditional formulations of pigmented coating systems are able to provide many
of these qualities; however, rarely are do those formulations provide a clear coat
15 at a cost reduction in excess of 10%.
DETAILED DESCRIPTION
The present invention is a dry powder generally comprising gum acacia, a
cellulosic polymer and plasticizers, whereby the dry powder can be used in an
aqueous solution for application as an edible coating for tablets, capsules,
20 confectionaries and the like.
The most preferred embodiment of this invention combines a substantial amount of gum acacia and hydroxypropyl methylcellulose ('TTPMC") in a dry powder to deliver a highly cost-effective film-forming polymer. Though traditionally used as a wetting agent or adhesive, the gum acacia functions as a
6

film former when combined with a cellulosic polymer such as HPMC. The film-forming polymers are combined with plasticizers such as polyethylene glycol to increase the elasticity of the resulting film coating.
The exact proportions of the gum acacia and HPMC in the present invention are not critical, although the most preferred embodiment of the composition is as follows: (1) HPMC 6 centipoise (hereinafter "cps"), (25.0% by weight); HPMC 15 cps, (20.0% by weight); gum acacia, (45.0% by weight); polyethylene glycol 400, (5.0% by weight); and polyethylene glycol 8,000, (5.0% by weight). Preferably, the gum acacia is obtained in powder form from Colloides Naturels International, as Gum Arabic (Spray Gum AS).
Thus the preferred embodiment, when applied to tablet substrates such as vitamins and dietary supplements, provides optimum physical characteristics as well as a substantial reduction in production costs. In contrast to the widely available pigmented coatings, the clear coat of the present invention exhibits comparable physical properties, such as elasticity, tensile strength and crushing strength. Significantly, the coating supports the evaporation of moisture off-of the surface of the substrate, rather than the migration of moisture into the core of the substrate.
Alternative embodiments of the present invention are shown below in Table 1. When gum acacia is added to a given formulation so that it is more than about 60% by weight of the dry powder composition, tackiness of the resulting film coating can occur. Therefore, detacjrifiers such as magnesium stearate and talc may be added to the composition when deemed desirable. Furthermore, maltodextrin or starch can be added as additional polymer film formers.
7


However, the polymers maltodextrm and starch, and the detackifier talc will yield a film that is less translucent than other formulations that do not contain these
components.
TABLE 1

COMPONENT COMPONENT FUNCTION PREFERRED RANGE (% BY WEIGHT) MOST
PREFERRED RANGE (% BY WEIGHT)
Gum Acacia Polymer/Film former 5.0-90.0% 5.0 - 60.0 %
Hydroxypropyl methylcellulose 3 cps Polymer/Film former 0.0 - 90.0 % 0.0 - 60.0 %
Hydroxypropyl methylcellulose 6cps Polymer/Film former 0.0 - 90.0 % 0.0 - 60.0 %
Hydroxypropyl methylcellulose 15 cps Polymer/Film former 0.0 - 90.0 % 0.0 - 30.0 %
Hydroxypropyl methylcellulose 50 cps Polymer/Film former 0.0 - 90.0 % 0.0-15.0%
Methylcellulose 15 cps Polymer/Film former 0.0 - 90.0 % 0.0 - 30.0 %
MaltodextrinM-180 Polymer/Film former 0.0-5.0% 0.0-5.0%
Starch Polymer/Film former 0.0 - 90.0 % 0.0-25.0%
Polyethylene glycol 400 Plasticizer 0.0-15.0% 0.0-10.0%
Polyethylene glycol 3,350 Plasticizer 0.0-15.0% 0.0-15.0%
Polyethylene glycol 8,000 Plasticizer 0.0-15.0% 0.0- 15.0%
Triacetin Plasticizer 0.0-15.0% 0.0- 10.0%
Glycerine Plasticizer 0.0-15.0% 0.0-10.0%
Triethyl Citrate Plasticizer 0.0-15.0% 0.0 - 10.0 %
Magnesium Stearate Detackifier 0.0-15.0% 0.0 - 5.0 %
Talc Detackifier 0.0 - 50.0 % 0.0-25.0%
In addition to the components listed in Table 1, other edible plasticizers, cellulosic polymers, and detackifiers can be used. For example, other plasticizers include propylene glycol, mineral oil, monoglycerides, dibutyl scbecate, acetyltriethylcitrate, acetyltributylcitrate, acetylated monoglyceride, hydroxylated lecithin or the like. Other cellulosic polymers include hydroxypropyl cellulose, hydroxyethylcellulose, hydroxyethyl methylcellulose, carboxymethylcellulose,
8

polyvinyl alcohol or the like. Other detackifiers include hydroxylated lecithin, stearic acid, hydrogenated vegetable oil, silica and wax. Detackifiers prevent coated tablets and the like from sticking together.
Pigments such as titanium dioxide, FD&C aluminum lakes, natural
.5 colorants, synthetic oxides or the like may also be used with any of the
formulations, but can negatively affect the coating clarity. Preferably, pigments are added to the final formulation so that the colored formulation contains pigment of up to about 25% by weight.
The following examples illustrate various formulations of the present
10 invention (all percentages are by weight):
15
20
25
30
35
EXAMPLE l
Gum Acacia 35.0 %
Hydroxypropyl methylcellulose 6 cps 45.0 %
Hydroxypropyl methylcellulose 15 cps 10.0 %
Polyethylene glycol 400 1.0%
Polyethylene glycol 8,000 9.0 %
EXAMPLE 2
Gum Acacia 25.0 %
Hydroxypropyl methylcellulose 6 cps 64.0 %
Hydroxypropyl methylcellulose 15 cps 1.0%
Polyethylene glycol 400 9.0 %
Polyethylene glycol 8,000 1.0%
EXAMPLE 3
Gum Acacia 45.0 %
Hydroxypropyl methylcellulose 6 cps 25.0 %
Hydroxypropyl methylcellulose 15 cps 10.0 %
Talc 10.0 %
Polyethylene glycol 400 5.0 %
Polyethylene glycol 8,000 5.0 %
EXAMPLE 4
Gum Acacia 45.0 %
Hydroxypropyl methylcellulose 6 cps 25.0 %
Hydroxypropyl methylcellulose 15 cps 10.0%
MaltodextrinM-180 10.0 %
Polyethylene glycol 400 5,0 %
9

10
15
20
25
30
35

Polyethylene glycol 8,000 5.0 %
EXAMPLE 5

Gum Acacia 45.0 %
Hydroxypropyl methylcellulose 6 cps 25.0 %
Hydroxypropyl methylcellulose 15 cps 10.0%
Starch 10.0%
Polyethylene glycol 400 5.0 %
Polyethylene glycol 8,000 5.0%
EXAMPLE 6
Gum Acacia 45.0%
Hydroxypropyl methylcellulose 6 cps 30.0 %
Hydroxypropyl methylcellulose 15 cps 15.0%
Triacetin 5.0 %
Polyethylene glycol 8,000 5.0 %
EXAMPLE 7
Gum Acacia 45.0 %
Hydroxypropyl methylcellulose 6 cps 30.0 %
Hydroxypropyl methylcellulose 15 cps 15.0%
Glycerine 5.0 %
Polyethylene glycol 8,000 5.0 %
EXAMPLE 8
Gum Acacia 45.0 %
Hydroxypropyl methylcellulose 6 cps 30.0 %
Hydroxypropyl methylcellulose 15 cps 15.0%
Triethyl Citrate 5.0 %
Polyethylene glycol 8,000 5.0 %
EXAMPLE 9
Gum Acacia 45.0 %
Hydroxypropyl methylcellulose 6 cps 30.0 %
Hydroxypropyl methylcellulose 15 cps 14.0 %
Polyethylene glycol 400 5.0 %
Polyethylene glycol 8,000 5.0 %
Magnesium Stearate 1.0 %

40 In the following examples, methylcellulose is substituted for HPMC.

45


EXAMPLE 10
Gum Acacia 45.0 %
Methylcellulose 15 cps 45.0 %
Polyethylene glycol 400 5.0%
Polyethylene glycol 8,000 5.0 %

10

EXAMPLE 11
Gum Acacia 45.0 %
Methylcellulose 15 cps 45.0%
Glycerine 10.0 %
EXAMPLE 12
Gum Acacia 45.0 %
Methylcellulose 15 cps 45.0%
Triacetin 10.0 %
Method of Preparation
The desired components of the present invention are blended as a dry powder in accordance with conventional practice. Preferably, components having the highest volume are added to the blending equipment prior to components having a relatively lesser volume. Such preparation will yield a free flowing, off-white powder that is water-soluble or water dispersible. When this dry powder is put into solution or suspension, it may be applied to tablets or the like, without having to wait several hours prior to application.
In the practice of the present invention, the preparation of a solution that can be used for quality control purposes proceeds as follows: (1) bring about one-half of the required amount of water to boiling (the required amount dependant on desired viscosity and formulation); (2) add the dry powder of the present invention under agitation until thoroughly wetted (optionally, pigments may be added after the dry powder); (3) bring to desired concentration with cold water; (4) stir until completely dissolved; (5) adjust the temperature.of the solution to 23°C; and (6) measure the solution until a flash point reading of 93.3°C (200F) is obtained.
11

In the practice of the present invention, the preparation of a solution that
can be used for coating tablets or the like proceeds as follows: (1) mix water to
the dry-powder composition of the present invention to obtain a ten percent
(10%) solution; (2) let the solution stand for about 30 minutes; and (3) spray the
5 solution onto the substrate. It is not necessary to heat the water. Therefore, cold
water can be used.
When dissolved in water, the composition yields a clear solution for
aqueous film coating with a low viscosity. In particular, when in solution, the
preferred embodiment's viscosity ranges from 75-150 cps when measured by the
10 Brookfield Small Chamber Method (Model RVTD) (10% w/w in water, USP;
Chamber 13R; Spindle #21; 100 RPM; 23°C). Viscosity is directly affected by the amount of water added to the solution, and the required amount of water will vary depending on the formulation of the'present invention.
The Ann-forming compositions of the invention are not prone to settling
15 or other breakdowns. Further, it is believed that such compositions remain free
from bacterial formation. The shelf life of this product is three years when stored in tight containers in the absence of excessive heat and/or moisture. Polyethylene-lined drums are acceptable packaging.
Although the invention has been herein shown and described in what is
20 conceived to be the most practical and preferred embodiment, it is recognized
that departures may be made therefrom within the scope of the invention which is not to be limited to the illustrative details disclosed.
12

WE CLAIM
1. A method of making a dry powder film forming composition capable of forming an
aqueous solution having a low viscosity ranging from 75 to 150 cps for use on pharmaceutical
tablets, food, and confectionary products, comprising the steps of:
mixing a dry^powdered cellulosic polymer, a film forming amount of gum acacia, and a plasticizer in a blender until thoroughly dry mixed form an edible film forming composition wherein said composition does not contain added water prior to being put into solution for application on said pharmaceutical tablets, food and confectionery products.
2. The method as claimed in claim 1, wherein said powdered cellulosic polymer is selected from a group consisting of hydroxypropyl methylcellulose, methylcellulose, hydroxethylmethyl cellulose, hydroxypropyl cellulose, or carboxymethyl cellulose.
3. The method as claimed in claim 1, wherein said gum acacia is selected from a group consisting of gum arabic, kordofan gum, Senegal gum, Indian gum and cape gum.
4. The method as claimed in claim 1, wherein said edible plasticizer is selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, triacetin, triethyl citrate, acetyltriethylcitrate, acetyltributylcitrate, or acetylated monoglyceride, mineral oil, monoglycerides and dibutyl seberate.
13

5. The method as claimed in claim 1, including blending a detackifier into said composition.
6. A method of making a dry powder film forming composition for use on pharmaceutical tablets, food and confectionary products, comprising the steps of mixing a dry powdered cellulosic polymer, gum acacia, and a plasticizer in a blender until thoroughly dry mixed to form a film forming composition, wherein the amount of cellulosic polymer in said composition is in the range of zero percent (0%) to ninety percent (90%) by weight, wherein the amount of gum acacia in said composition is in the range of five percent (5%) to ninety percent (90%) by weight, and wherein the amount of plasticizer in said composition is in the range of zero percent (0%) to fifteen percent (15%) by weight.
7. The method as claimed in claim 6, wherein said powdered cellulosic polymer is selected from the group consisting of hydroxypropyl methycellulose, methycellulose, hydroxyethyl methylcellulose, hydroxypropyl cellulose, or carboxymethyl cellulose.
8. The method as claimed in claim 6, wherein said gum acacia is selected from the group consisting of gum arabic, kordofan gum, Senegal gum, Indian gum, and cape gum.
9. The method as claimed in claim 6, wherein said edible plasticizer is selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, triacetin, triethyl citrate, acetyltriethylcitrate, acetyltributylcitrate, or acetylated monoglyceride, mineral oil, monoglycerides and dibutyl seberate.
14

10. The method as claimed in claim 6, including blending a detackifier into said composition.
11. A method of making a solution from a dry powder film forming composition for use on pharmaceutical tablets, food, and confectionary products, comprising the steps of:
blending a^dry powdered cellulosic polymer, gum acacia, and plasticizer in a blender until thoroughly dry mixed to form the film forming composition, wherein the amount of cellulose polymer in said composition is in the range of zero percent (0%) to ninety percent (90%) by weight, wherein the amount of gum acacia in said composition is in the range of five percent (5%) to ninety percent (90%) by weight, and wherein the amount of plasticizer in said composition is in the range of zero percent (0%) to fifteen percent (15%) by weight;
boiling a first quantity of water;
adding the blended dry powder to the boiling water;
agitating the water and dry powder until thoroughly wetted;
adding a second quantity of water to bring the solution to a desired concentration; and
stirring until the dry powder is dissolved.
12. The method as claimed in claim 11 further including the step of adding a second quantity of water until the viscosity of the solution is about 75 to 150 cps.
13. The method as claimed in claim 12 wherein the first quantity of water is approximately equal.to the second quantity of water.
15

14. The method as claimed in claim 11 includes the steps of adjusting the temperature of the
solution to 23 degrees C, and measuring the solution until a flash point reading of about 93.3
degrees C is obtained.
15. A method of making a solution from a dry powder film forming composition for use on
substrate such as pharmaceutical tablets, food and confectionary products, comprising the steps
of:
blending a dry powdered cellulose polymer, gum acacia, and a plasticizer in a blender until thoroughly dry mixed to form the film forming composition, wherein the amount of cellulosic polymer in said composition is in the range of zero percent (0%) to ninety percent (90%) by weight, wherein the amount of gum acacia in said composition is in the range of five percent (5%) to ninety percent (90%) by weight, and wherein the amount of plasticizer in said composition is in the range of zero percent (0%) to fifteen percent (15%) by weight;
mixing water to the solution;
allowing the solution to stand; and
spraying the solution onto the substrate.
Dated this 3rd day of March 2003

16

Documents:

277-mumnp-2003-cancelled pages(29-3-2005).pdf

277-mumnp-2003-claims(4-3-2003).pdf

277-mumnp-2003-claims(granted)-(26-10-2007).pdf

277-mumnp-2003-claims(granted)-(29-03-2005).doc

277-mumnp-2003-claims(granted)-(29-3-2005).pdf

277-mumnp-2003-claims(granted)-(5-10-2007).pdf

277-mumnp-2003-correspondence(1-4-2005).pdf

277-mumnp-2003-correspondence(ipo)-(12-11-2007).pdf

277-mumnp-2003-correspondence(ipo)-(5-10-2007).pdf

277-mumnp-2003-description(complete)-(4-3-2003).pdf

277-mumnp-2003-description(granted)-(26-10-2007).pdf

277-mumnp-2003-description(granted)-(5-10-2007).pdf

277-mumnp-2003-form 1(1-4-2005).pdf

277-mumnp-2003-form 13(29-3-2005).pdf

277-mumnp-2003-form 19(17-2-2004).pdf

277-mumnp-2003-form 1a(4-3-2003).pdf

277-mumnp-2003-form 2(complete)-(4-3-2003).pdf

277-mumnp-2003-form 2(granted)-(26-10-2007).pdf

277-mumnp-2003-form 2(granted)-(29-03-2005).doc

277-mumnp-2003-form 2(granted)-(29-3-2005).pdf

277-mumnp-2003-form 2(granted)-(5-10-2007).pdf

277-mumnp-2003-form 2(title page)-(4-3-2003).pdf

277-mumnp-2003-form 2(title page)-(granted)-(26-10-2007).pdf

277-mumnp-2003-form 2(title page)-(granted)-(5-10-2007).pdf

277-mumnp-2003-form 3(29-3-2005).pdf

277-mumnp-2003-form 3(3-3-2003).pdf

277-mumnp-2003-form 5(3-3-2003).pdf

277-mumnp-2003-form-pct-ipea-409(4-3-2003).pdf

277-mumnp-2003-form-pct-isa-210(4-3-2003).pdf

277-mumnp-2003-petition under rule 137(1-4-2005).pdf

277-mumnp-2003-power of attorney(22-7-2004).pdf

277-mumnp-2003-power of attorney(27-5-2003).pdf

277-mumnp-2003-specification(amended)-(29-3-2005).pdf

277-mumnp-2003-wo international publication report(4-3-2003).pdf


Patent Number 210516
Indian Patent Application Number 277/MUMNP/2003
PG Journal Number 45/2007
Publication Date 09-Nov-2007
Grant Date 05-Oct-2007
Date of Filing 04-Mar-2003
Name of Patentee CHR. HANSEN, INC.
Applicant Address 9015 WEST MAPLE STREET, MILWAUKEE, WISCONSIN-
Inventors:
# Inventor's Name Inventor's Address
1 GAYSER CHARLES W JR 57 BROOKSIDE DRIVE WEST, HARRIMAN, NEW YORK-10296.
2 GOYETTE, JEAN PAUL 22 BENNET POND ROAD, CANTEBURY, CONNECTICUT, 06331.
PCT International Classification Number A61K9/14
PCT International Application Number PCT/US01/26986
PCT International Filing date 2001-08-29
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 09/656,082 2000-09-06 IB