Title of Invention	A METHOD FOR SELECTION OF AN IMMUNOGENIC ANALOGUE OF A CELL ASSOCIATED POLYPEPTIDE ANTIGEN
Abstract	A method is disclosed for inducing cell-mediated immunity against cellular antigens. More specifically, the invention provides for a method for inducing cytotoxic T-lymphocyte immunity against weak antigens, notably self-proteins. The method entails that antigen presenting cells are induced to present at least one CTL epitope of the weak antigen and at the same time presenting at least one foreign T-helper lymphocyte epitope. In a preferred embodiment, the antigen is a cancer specific antigen, e.g. PSM, Her2, or FGF8b. The method can be exercised by using traditional polypeptide vaccination, but also by using live attenuated vaccines or nucleic acid vaccination. The invention furthermore provides immunogenic analogues of PSM, Her2 and FGF8b, as well as nucleic acid molecules encoding these analogues. Also vectors and transformed cells are disclosed. The invention also provides for a method for identification of immunogenic analogues of weak or non-immunogenic antigens.

Title of Invention

A METHOD FOR SELECTION OF AN IMMUNOGENIC ANALOGUE OF A CELL ASSOCIATED POLYPEPTIDE ANTIGEN

Abstract

A method is disclosed for inducing cell-mediated immunity against cellular antigens. More specifically, the invention provides for a method for inducing cytotoxic T-lymphocyte immunity against weak antigens, notably self-proteins. The method entails that antigen presenting cells are induced to present at least one CTL epitope of the weak antigen and at the same time presenting at least one foreign T-helper lymphocyte epitope. In a preferred embodiment, the antigen is a cancer specific antigen, e.g. PSM, Her2, or FGF8b. The method can be exercised by using traditional polypeptide vaccination, but also by using live attenuated vaccines or nucleic acid vaccination. The invention furthermore provides immunogenic analogues of PSM, Her2 and FGF8b, as well as nucleic acid molecules encoding these analogues. Also vectors and transformed cells are disclosed. The invention also provides for a method for identification of immunogenic analogues of weak or non-immunogenic antigens.

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Patent Number

210468

Indian Patent Application Number

IN/PCT/2001/00381/MUM

PG Journal Number

45/2007

Publication Date

09-Nov-2007

Grant Date

04-Oct-2007

Date of Filing

10-Apr-2001

Name of Patentee

PHARMEXA A/S.

Applicant Address

KOGLE ALLE 6, DK-2970 HORSHOLM, DENMARK

Inventors:

#	Inventor's Name	Inventor's Address
1	LUCILLA STEINNA	VIKTORIAGADE 28, 3 TH., DK-1655, COPENHAGEN V, DENMARK
2	SOREN MOURITSEN	HOVELTEVEJ 78, DK-3460, BIKEROD,
3	ANAND GAUTAM	SOLAGER 4, NIVEROD, DK-2990 NIVA,
4	IBEN DALUM	OLGASVEJ 13,DK-2970 HORSHOLM,
5	JESPER HAANING	BISKOP SVANES VEJ 2E, DK-3460 BIRKERO
6	DANA LEACH	COLLINSGADE 6, 1. TV. DK-2100 COPENHAGEN O,
7	KLAUS GREGORIUS NIELSEN	LYKKESBORG ALLE 15, DK-2860 SOBORG
8	GUNILLA KARLSSON	COLLINSGADE 6A, 3. TV., DK-2100 COPENHAGEN O,
9	PETER BIRK RASMUSSEN	A.D. JORGENSENSVEJ 31, DK-2000 FREDERIKSBERG,

PCT International Classification Number

A61K 39/00

PCT International Application Number

PCT/DK99/00525

PCT International Filing date

1999-10-05

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/105,011	1998-10-20	Denmark
2	PA 1998 01261	1998-10-05	Denmark