Title of Invention	"N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS"
Abstract	"N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS" ABSTRACT The present invention relates to a N-heterocyclic compound of formula (Ya), formula (Yb) or formula (Yc): wherein, n, m, A, w, Rl, R2, R4 and R5 are as defined and a pharmaceutical composition thereof.

Full Text

FORM 2 THE PATENTS ACT 1970 [39 OF 1970] COMPLETE SPECIFICATION [See Section 10] "N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS" BERLEX LABORATORIES, INC., of 15049 San Pablo Avenue, P.O. Box 4099, Richmond, CA 94804-0099, United States of America and PHARMACOPEIA, INC., of 3000 Eastpark Boulevard, Cranbury, NJ 08512, United States of America, The following specification particularly describes the nature of the invention and the manner in which it is to be performed:- Field of the invention The invention relates to a series of N-heterocyclic compounds and derivatives useful as inhibitors of nitric oxide synthase (NOS) and to methods of therapy for various diseases employing those compounds. . Background of the Invention Nitrogen monoxide (MO) has been implicated in a number of diverse physiological processes, including smooth muscle relaxation, platelet inhibition, nerve transmission, immune regulation and penile erection. Nitric oxide is produced under various conditions by virtually all nucleated mammalian cells. A number of pathologies are ascribed to abnormalities in NO production including stroke, insulin dependent diabetes, septic shock-induced hypotension, rheumatoid arthritis and multiple sclerosis. Nitric oxide is synthesized in biological tissues by an enzyme called nitric oxide synthase (NOS) which uses NADPH and molecular oxygen to oxidize L-arginine to citrulline and nitric oxide. . Nitric oxide synthase (NOS) exists in at least three isoforms, which fall into two primary, categories: constitutive and inducible. Two constitutive isoforms, which are calcium and calmodulin dependent, have been identified, and one inducible isoform has been identified. The constitutive isoforms are (1) a neurdnal isoform, NOS-1 or nNOS, which is found in the brain and skeletal muscles and (2) an endothelial isoform, NOS-3 or eNOS, which is expressed in the endothelium of blood vessels, the epithelium of the bronchial tree and in the brain. These constitutive isoforms are not the target of the NOS inhibitors of the present invention. The inducible isoform (NOS2 or iNOS) is expressed in virtually all nucleated, mammalian cells following exposure to inflammatory cytokines or lipopolysaccharide. Its presence in macrophages'and lung epithelial cells is particularly noteworthy. The inducible isoform is neither stimulated by calcium nor blocked by calmodulin antagonists. It contains several tightly bound co-factors, including FMN, FAD and tetrahydrobiopterin. Nitric oxide generated by the inducible form of NOS has been implicated in the pathogenesis of inflammatory diseases. In experimental animals, hypotension induced by lipopolysaccharide or tumor necrosis factor a can be reversed by NOS inhibitors. Conditions which lead to cytokine-induced hypotension include septic shock,- hemodialysis and interleukin therapy in cancer patients. It is expected that an iNOS inhibitor would be effective in treating cytokine-induced hypotension, in addition, recent studies have suggested a role for NO in the pathogenesis of inflammation, and NOS inhibitors would therefore have beneficial effects on inflammatory bowel disease, cerebral ischemia and arthritis. Inhibitors of NOS may also be useful in treating adult respiratory distress syndrome (ARDS) and myocarditis, and they may be useful as adjuvants to short term immunosuppression in transplant therapy. WO 01/14371 PCT/US00/23173 The diversity and ubiquity of NO function in physiology make the specific therapeutic targeting of NO-related phenomena an important consideration. Since endogenous NO production is the result of the actions of related but distinct isozymes, the differential inhibition of NOS isozymes allows more selective therapy with fewer side effects. SUMMARY OF THE INVENTION In one aspect, the invention is directed to compounds of formula (Ya), formula (Yb) and formula (Yc): R-(CH2) .(CH2)n-A N 10 wherein: n and m are each independently an integer from 1 to 4; WO 01/14371 PCT/US00/23173 A is -C(0)OR1 or -C(0)N(R1)R2; each W is N or CH; each R1 is independently hydrogen, alkyl, aryl or aralkyl; each R2 is independently hydrogen, C0-C20 alkyl, -(CH2)n-N(R')2, heterocyclylalkyl (optionally 5 substituted by alkyl, halo, haloalkyl or alkoxy), aralkyl (optionally substituted by halo, alkyl, alkoxy, or -N(R1)2); R4 is hydroxy, cyano, heterocyclyl, -N(R')R2, -N(R')-C(0)-R\ -N(R1)-C(0)OR\ -N(R1)-S(0)t-R1, or-N(R1)-C(0)-N(R1)2; R5 is hydrogen, halo, alkyl, aryl, aralkyl, or haloalkyl; 10 as a single stereoisomer or mixture thereto, or a pharmaceuticalfy acceptable salt thereof. In another aspect, the invention is directed to compounds of formula (IV): R1 wherein: AA is an amino acid; 15 X, Y and Z are independently N or C(R19); U is N or C(R5), provided that U is N only when X is N and 2 and Y are GR19; WisNorCH; R1 and R2 are independently chosen from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted cycloalkyl, -[C0-Ca alkyl]-R9, -[C2-C8 alkenyl]-R9, 20 -[C2C8 alkynyl]-R9, -[C2-C8 alkyl]-R10 (optionally substituted by hydroxy), -[C1-C8]-R11 (optionally substituted by hydroxy), and optionally substituted heterocyclyl; or Rf and R2 together with the nitrogen atom to which they are attached is an optionally substituted N-heterocyclyl; R5 is chosen from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted 25 aralkyl, optionally substituted aryl,-OR16,-S(0)l-R,8l-N(R16)R2',-N(R16)C(0)N(R1)R16, -N(R,6)C(0)OR,s, -N(Rl6)C(0)R16, -[C0-C8 alkyl]-C(0)OR16, -[C0-C8 alkyl]-C(H)[C(0)OR16]2, and -[C0-C8 alkyl]-C(0)N(R1)R16; each R9 is independently chosen from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one 30 or more substituents selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently chosen from the group consisting of halo, alkoxy, optionally substituted PCT/USOO/23173 aryloxy, optionally substituted aralkoxy, optionally substituted -S(O)1-R22, acylamino, amino, monoalkylamino, dialkylamino, (triphenyimethyl)amino, hydroxy, mercapto, and alkylsulfonamido; each R11 is independently chosen from the group consisting of cyano, di(alkoxy)alkyl, carboxy, 5 alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R19 is hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, 10 -C(O)R22 or - SO2R22 or R21 taken together with R1- and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; or R21 taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; 15 each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and t is zero, one or two; as a single isomer or mixture thereof, or a pharmaceutically acceptable salt thereof. In another aspect, the invention is directed to pharmaceutical compositions comprising a 20 compound of formula (Ya), formula (Yb), and formula (Yc), as described above, and a pharmaceutically acceptable carrier. In another aspect, the invention is directed to methods of treating a condition resulting from an abnormality in nitric oxide production which comprises administering to a mammal having a condition resulting from an abnormality in nitric oxide production a therapeutically effective 25 amount of compound of formula (Ya), formula (Yb), and formula (Yc), as described above. Detailed Description of the Invention Definitions As used in this specification and appended claims, unless specified to the contrary, the 30 following terms have the meaning indicated: "Alkyl" refers to a straight or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, containing no unsaturation, having from one to eight carbon atoms, and which is attached to the rest of the molecule by a single bond, e.g., methyl, ethyl, n-propyl, 1-methylethyl (/so-propyl), n-butyl, n-perityl, 1,1-dimethylethyl (/-butyl), and the like. Alkyl radicals 35 having more than eight carbon atoms are indicated herein by the notation "[Cx-Cy alkyt]" where x and y indicate the number of carbons present. Alkyl radicals may be optionally substituted by one or more substituents independently selected from the group consisting of halo, hydroxy, alkoxy, carboxy, cyano, carbonyl, alkoxycarbonyl, cyano, amino, monoalkylamino, dialkylamino, nitro, WO 01/14371 PCT/USOO/23173 alkylthio, amidino, aryl, heterocyclyl, aryloxy, aralkoxy, acylamino, aminocarbonyl, monoalkylaminocarbonyl, and dialkylaminocarbonyl. , "Alkenyl" refers to a straight or branched chain monovalent or divalent radical consisting solely of carbon and hydrogen, containing at least one double bond and having from one to eight 5 carbon atoms, e.g., ethenyl, prop-1-enyl, but-1-enyl, pent-1-enyl, penta-1,4-dienyl, and the like. "Alkynyl" refers to a straight or branched chain monovalent or divalent radical consisting solely of carbon and hydrogen, containing at least one triple bond and having from one to eight carbon atoms, e.g., ethynyl, prop-1-ynyl, but-1-ynyl, pent-1-ynyl, pent-3-ynyl, and the like. "Alkoxy" refers to a radical of the formula -ORa where Ra is an alkyl radical as defined 10 above, e.g., methoxy, ethoxy, propoxy, and the like. "Alkoxycarbonyl" refers to a radical of the formula-C(0)ORa where Ra is an alkyl radical as defined above, e.g., methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, and the like. "Alkoxycarbonylalkyl" refers to a radical of the formula -Ra-C(0)ORa where each Ra is independently an alkyl radical as defined above, e.g., 2-(methoxycarbonyl)ethyl, 15 3-(ethoxycarbonyl)propyl,4-(n-propoxycarbonyl)butyl, and the like. "Alkylsulfonylamino" refers to a radical of the formula -N(H)S(0)2-Ra where Ra is an alkyl radical as defined above, e.g., methylsulfonylamino, ethylsulfonylamino, and the like. "Alkyisulfonyl" refers to a radical of the formula -S(0)2-Ra where Ra is an alkyl radical as defined above, e.g., methylsulfonyl, ethylsulfonyl, and the like. 20 "Alkylthio" refers to a radical of the formula -S-Ra where Ra is an alkyl radical as defined above, e.g., methylthio, ethylthio, n-propylthio, and the like. "Amidino" refers to a radical of the formula -C(NH)-NH2. "Amino" refers to a radical of the formula -NH2. "Aminocarbonyl" refers to a radical of the formula -C(0)NH2. 25 "Aminosulfonyl" refers to a radical of the formula -S(0)2NH2. "Aryl" refers to a phenyl or naphthyl radical. The aryl radical may be optionally substituted by one or more substituents selected from the group consisting of hydroxy, mercapto, halo, alkyl, aJkeriyl, alkny), phenyl, phenylalkyl, phenylalkenyl, alkoxy, phenoxy, phenylalkoxy, haloalkyl, haloalkoxy, formyl, nitro, cyano, cycloalkyl, hydroxyalkyl, alkoxyalkyl, phenoxyalkyl, 30 phenylalkoxyalkyi, amidino, ureido, alkoxycarbonyamino, amino, monoalkylamino, dialkylamino, monophenylamino, monophenylalkylamino, sulfonylamino, akylsuifonylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, monophenylaminoalkyl, monophenylalkylaminoalkyl, acyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminocarbonyl alkyl, monoalkylaminocarbonylalkyl, and 35 dia/kylaminocarbonyla/ky/, as defined herein. "Aralkyl" refers to a radical of the formula -RaR6 where Ra is an alkyl radical as defined above and Ra is an aryl radical as defined above, e.g., benzyl, and the like. The aryl radical may be optionally substituted as described above. WO 01/14371 PCT/US00/23173 "Aryloxy" refers to a radical of frie formula -ORb where Rb 'is an aryl radical as defined above, e.g., phenoxy and naphthoxy, and the like. The aryl radical may be optionally substituted as described above. "Aryloxycarbonyl" refers to a radical of the formula -0(0)0Rb where Rb is an aryl radical 5 as defined above, e.g., phenoxycarbonyl. "Aralkoxy" refers to a radical of the formula -ORc where Rc. is an araikyi radical as defined above, e.g., benzyloxy, and the like. The araikyi radical rnay be optionally substituted as described above. "Aralkoxycarbonyl" refers to a radical of the formula -C(0)ORc where Rc. is an araikyi 10 radical as defined above, e.g., benzyloxycarbonyl, and the like. The araikyi radical may be optionally substituted as described above. "Arylaminocarbonyl" refers to a radical of the forrnuia -C(0)N(Rb)H where Rb is an aryl radical as defined above, e.g., phenylaminocarbonyl, and the like. The aryl radical may be optionally substituted as described above. 15 "Arylaminosulfonyl" refers to a radical of the formula -S(0)2N(Rb)H where Rb is an aryl radical as defined above, e.g., phenylaminosulfonyl, and the like. The aryl radical may be optionally substituted as described above. "Arylsulfonyl" refers to a radical of the formula -S(0)2-Rb where Rb is an aryl radical as defined above, e.g., phenylsulfonyl, and the like. The aryl radical may be optionally substituted 20 as described above. "Arylsulfonylaminocarbonyl" refers to a radical of the formula -C(0)N(H)S(0)2Rb where Rb is an aryl radical as defined above, e.g., phenylsulfonylaminocarbonyl, and the like. The aryl radical may be optionally substituted as described above, "Acyl" refers to a radical of the formula -C(0)-Ra and -C(0)Rb where Ra is an alkyl radical 25 as defined above and Rb is an aryl radical as defined above, e.g., acetyl, propionyl, benzoyl, and the like. "Acylamino" refers to a radical of the formula -N(H)-C(0)-Ra and -N(H)-C(0)-Rb where Ra is an alkyl radical as defined above and Rb is an aryl radical as defined above, e.g., acetylarnino, benzoylamino and the like. 30 "Alkylene" refers to straight or branched chain divalent radical consisting solely of carbonyl and hydrogen, containing no unsaturation and having from one to eight carbon atoms, e.g., methylene, ethylene, propylene, n-butylene, and the like. The alkylene radical may be optionally substituted by one or more substituents selected from the group consisting of alkyl, hydroxy, -N(R16)R21 or -C(0)N(R1)R16 where R\ R16 and B21 are as defined above in the 35 Summary of the Invention. "Cycloalkyl" refers to a stable 3- to 10-membered monocyclic or bicyclic radical which is saturated, and which consist solely of carbon and hydrogen atoms, e.g., cyclopropyl, cyclobutyl, cyclobutyl, cyclohexyl, decalinyl and the like. Unless otherwise stated specifically in the WO 01/14371 PCT/US00/23173 specification, the term "cycloalkyl" is meant to include cycloalkyl radicals which are optionally substituted by one or more substituents independently selected from the group consisting of alkyl, halo, hydroxy, amino, cyano, nitro, alkoxy, carboxy and alkoxycarbonyl. "Carboxy" refers to the radical of the formula -C(O)0H. 5 "Carboxyalkyl" refers to a radical of the formula -Ra-C(0)OH where Ra is an alkyl radical as defined above, e.g., carboxy methyl, 2-carboxy ethyl, 3-carboxypropyl, and the like. "Di(alkoxy)alkyl" refers to a radical of the formula -Ra(-OR1)2 where each Ra is independently an alkyl radical as defined above and where the -ORa groups may be attached to any carbon in the Ra group, e.g., 3,3-dimethoxypropyl, 2,3-dimethoxypropyl, and the like. 10 "Dialkylamino" refers to a radical of the formula -N(Ra)Ra where each Ra is independently an alkyl radical as defined above, e.g., dimethylamino, diethylamino, (methyl)(ethyl)amino, and the like. "Dialkylaminocarbonyl" refers to a radical of the formula -C(0)N(Ra)Ra where each Ra is independently an alkyl radical as defined above, e.g., dimethylaminocarbonyl, 15 methylethylaminocarbonyl, diethylaminocarbonyl, dipropylaminocarbonyl, ethylpropylaminocarbonyl, and the like. "Dialkylaminosulfonyl" refers to a radical of the formula -S(0)zN(Ra)Ra where each Ra is independently an alkyl radical as defined above, e.g., dimethylaminosulfonyl, methylethylaminosulfonyl, diethylaminosulfonyl, dipropylaminsulfonyl, ethylpropylaminosulfonyl, 20 and the like. "Halo" refers to bromo, chloro, iodo or fluoro. "Haloalkyl" refers to an alkyl radical, as defined above, that is substituted by one or more halo radicals, as defined above, e.g., trifluoromethyl, difluoromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 1-fluoromethyl-2-fluoroethyl, 3-bromo-2-fluoropropyl, 25 • 1-bromomethyl-2-bromoethyl, and the like. "Haloalkoxy" refers to a radical of the formula -ORd where Rd is an haloalkyl radical as defined above, e.g., trifluoromethoxy, difluoromethoxy, trichloromethoxy, 2,2,2-trifluoroethoxy, 1-fluoromethyl-2-fluoroethoxy, 3-bromo-2-fluoropropoxy, 1-bromomethyl-2-bromoethoxy, and the like. 30 "Heterocyclyl" refers to a stable 3- to 15-membered ring radical which consists of carbon atoms and from one to five heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur. For purposes of this invention, the heterocyclyl radical may be a monocyclic, bicyciic or tricyclic ring system, which may include fused or bridged ring systems; and the nitrogen, carbon or sulfur atoms in the heterocyclyl radical may be optionally'oxidized; the nitrogen atom 35 may be optionally quatemized; and the heterocyclyl radical may be partially or fully saturated or aromatic. The heterocyclyl radical may be attached to the main structure at any heteroatom or carbon atom which results in the creation of a stable compound. Examples of such heterocyclyl radicals include, but are not limited to, azepinyl, azetidinyl, acridinyl, benzimidazolyi, WO 01/14371 I PCT/US00/23173 benzodioxolyl, benzodioxanyl, benzothiazolyl, benzoxazolyl, benzopyranyl, benzofuranyl, benzothienyl, carbazolyl, cinnolinyl, decahydroisoquinolyl, dioxolanyl, furyl, isothiazolyi, quinuclidinyl, imidazolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, indoiyl, isoindolyl, indolinyl, isoindolinyl, indolizinyl, isoxazolyl, isoxazolidinyl, morpholinyl, naphthyridinyl, oxadiazolyl, 5 octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 2-oxoazepinyl, oxazolyt, oxazolidinyl, perhydroazepinyl, piperidinyl, piperazinyl, 4-pipehdonyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl.pyrrolyl, pyrrolidinyl, pyrazolyl, pyrazolidinyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, quinazolinyl, quinoxalinyl, quinolinyi, quinuclidinyl, isoquinolinyl, thiazolyl, thiazolidinyl, thiadiazolyl, triazolyl, tetrazolyl, 10 tetrahydrofuryl, tetrahydropyranyl, tetrahydroisoquinolyl, thienyl, thiomorpholinyl, thiomorpholinyl sulfoxide, and thiomorpholinyl sulfone. The heterocyclyl radical may be optionally substituted by R6 as defined above in the Summary of the Invention or may be optionally substituted by one or more substituents selected from the group consisting of hydroxy, mercapto, halo, alkyl, alkenyl, alkynyl, phenyl, phenylalkyl, phenylalkenyl, alkoxy, phenoxy, phenylalkoxy, haloalkyl, haloalkoxy, 15 formyl, nitro, cyano, amidino, cycloalkyl, hydroxyalkyl, alkoxyalkyl, phenoxyalkyl, phenylalkoxyalkyl, amidino, ureido, alkoxycarbonyamino, amino, monoalkylamino, dialkylamino, monophenylamino, monophenylalkylamino, aminoalkyl, monoalkylaminoalkyl, dialkyiaminoalkyl, monophenylaminoalkyl, monophenylalkylaminoalkyl, alkylcarbonyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, 20 aminocarbonylalkyi, monoalkylaminocarbonylalkyi, dialkylaminocarbonylalkyl, and imidazolyl, as defined herein. "Heterocyclylalky" refers to a radical of the formula -Ra-Re where Ra is an alkyl radical as defined above and Re is a heterocyclyl radical as defined above, e.g., 2-(1,3-benzodioxol-5-yl)ethyl, and 3-(1,4-benzodioxan-6-yl)propyl, and the like. 25 "Monoalkylamino" refers to a radical of the formula -N(H)Ra where Ra is an alkyl radical as defined above, e.g., methylamino, ethylamino, propylamine and the like. "Monoalkylaminocarbonyl" refers to a radical of the formula -C(0)N(H)Ra where Ra is an alkyl radical as defined above, e.g., methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, and the like. 30 "Monoalkylaminosulfony" refers to a radical of the formula -S(0)2N(H)Ra where Rais an alkyl radical as defined above, e.g., methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, and the like. "A/-heterocyclyl" refers to a heterocyclyl radical as defined above which contains at least one nitrogen atom and which is attached to the main structure through the nitrogen atom. The N- 35 heterocyclyl radical may contain up to three additional hetero atoms. Examples include piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, azetidinyl, indoiyl, pyrrolyl, imidazolyl, tetrahydroisoquinolyl, perhydroazepinyl, tetrazolyl, triazolyl, oxazinyl, and the like, and may be optionally substituted as described above for heterocyclyl radicals. In addition to being WO 01/14371 PCT/US00/23173 optionally substituted by the substituents listed above for a heterocyclyl radical, the N-heterocyclyl radical may also be optionally substituted by R6 as defined above in the Summary of the Invention. "Phenylalkyl" refers to an alky! radical as defined above substituted by a phenyl radical, 5 e.g., benzyl, and the like. "Optional" or "optionally" means that the subsequently described event of circumstances may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not. For example, "optionally substituted aryl" means that the aryl radical may or may not be substituted and that the description includes both substituted aryl 10 radicals and aryl radicals having no substitution. The term "-[C2C8 alkyl]-R10 (optionally substituted by hydroxy)" means that the alkyl has the optional substitution. The same goes for the term "-[C1-C8 alkyl]-R11 (optionally substituted by hydroxy)". The term "optionally substituted -S(b),R22" means that the R22 substituents all have the optional substitution. "Phenylalkenyl" refers to an alkenyl radical as defined above substituted by a phenyl 15 radical. The term "pharmaceutically acceptable salt" refers to salts prepared from pharmaceutically acceptable non-toxic acids Or bases including inorganic acids and bases and organic acids and bases. When the compounds of the present invention are basic, salts may be prepared from pharmaceutically acceptable non-toxic acids including inorganic and organic 20 acids. Suitable pharmaceutically acceptable acid addition salts for the compounds of the present invention include acetic, benzenesulfonic (besylate), benzoic, camphorsulfonic, citric, ethenesulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, malic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric acid, p-toluenesuifonic, and the like. When the compounds contain an acidic 25 side chain, suitable pharmaceutically acceptable base addition salts for the compounds of the present invention include metallic salts made from aluminum, calcium, lithium, magnesium, potassium, sodium and zinc or organic salts made from lysine,N,N'-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N-methylglucamine) and procaine. 30 "Therapeutically effective amount" refers to that amount of a compound of the invention which, when administered to a human in need thereof, is sufficient to effect treatment, as defined below, for conditions resulting from an abnormality in nitric oxide production. The amount of a compound of the invention which constitutes a "therapeutically effective amount" will vary depending on the compound, the condition and its severity, and the age of the human to be 35 treated, but can be determined routinely by one of ordinary skill in the art having regard to his own knowledge and to this, disclosure. Treating" or "treatment" as used herein covers the treatment of a condition in a human, which condition results from an abnormality in nitric oxide production, and includes: WO 01/14371 PCT/US00/23173 (i) preventing the condition from occurring in a human, in particular, when such human is predisposed to the condition but has not yet been diagnosed as having it; (ii) inhibiting the condition, i.e., arresting its development; or (iii) relieving the condition,, i.e., causing regression of the condition. 5 The yield of each of the reactions described herein is expressed as a percentage of the theoretical yield. Most of the compounds described herein contain one or more asymmetric centers and may thus give rise to enantiomers, diastereomers, and other stereoisomeric forms that may be defined, in terms of absolute stereochemistry, as (R)- or (S)- or, as (D)- or (L)- for amino acids. 10 The present invention is meant to include all such possible isomers, as well as, their racemic and optically pure forms. Optically active (R)- and (S)-, or (D)- and (L)- isomers may be prepared using chiral synthons or chiral reagents, or resolved using conventional techniques. When the compounds described herein contain olefinic double bonds or other centers of geometric asymmetry, and unless specified otherwise, it is intended that the compounds include both E and 15 Z geometric isomers. Likewise, all tautomeric forms are also intended to be included. The nomenclature used herein is a modified form of the I.U.P.A.C. nomenclature system wherein the compounds of the invention are named herein as amide derivatives. For example, the following compound of the invention: 20 is named herein as 2-[[3-[(1,3-benzodioxol-5-yl)methyl]aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N,N-diethylacetamide. Unless otherwise indicated, compound names are intended to include any single stereoisomer, enantiomer, racemate or mixtures thereof. 25 Utility of the Compounds of the Invention Nitric oxide generated by the inducible form of nitric oxide synthase (i-NOS) has been implicated in the pathogenesis of numerous inflammatory and autoimmune diseases and also in diseases which are generally not regarded as inflammatory, but nevertheless may involve cytokines which locally up-regulate i-NOS. The compounds of the invention, alone or in 30 combination with other pharmaceutical agents, are therefore useful in treating mammals, WO 01/14371 PCT/US00/23173 preferably humans, having a condition resulting from an abnormality in nitric oxide production. Such conditions include, but are not limited to, the following: Multiple sclerosis (Parkinson, J.F. ef al., J. Mol. Med. (1997), Vol. 75, pp. 174-186); stroke or cerebral ischemia (ladecola, C. ef al., J. Neurosci. (1997), Vol. 17, pp. 9157-9164); 5 Alzheimer's disease (Smith, M.A. et al., J. Neurosci. (1997), Vol. 17, pp. 2653-2657; Wallace, M.N. ef al., Exp. Neurol. (1997), Vol. 144, pp. 266-272); HIV dementia (Adamson D.C. ef al., Science (1996), Vol. 274, pp. 1917-1921); Parkinson's disease (Hunot, S. et al., Neuroscience (1996), Vol. 72, pp. 355-363); meningitis (Koedel, U. ef al., Ann. Neurol. (1995), Vol, 37, pp. 313-323); dilated cardiomyopathy and congestive heart failure (Satoh M etal., J. Am. Coll. Cardiol. 10 (1997), Vol. 29, pp. 716-724); atherosclerosis (Wilcox, J.N. etal., Arterioscler. Thromb. Vasc. Biol. (1997), Vol. 17, pp. 2479-2488); restenosis or graft stenosis, septic shock and hypotension (Petros, A. ef al., Cardiovasc. Res. (1994), Vol. 28, pp. 34-39); hemorrhagic shock (Thiemermarin, C. ef al., Proc. Natl. Acad. Sci. (1993), Vol. 90, pp. 267-271); asthma (Barnes, P.J., Ann. Med. (1995), Vol. 27, pp. 389-393; Flak, T.A. ef al., Am. J. Respir. Crit. Care Med. 15 (1996), Vol. 154, pp. S202-S206); adult respiratory distress syndrome, smoke or particulate-. mediated lung injury (Ischiropoulos, H. ef al.. Am. J. Respir. Crit. Care Med, (1994), Vol. 150, pp. 337-341; Van Dyke, K., Agents Actions (1994), Vol. 41, pp. 44-49); pathogen-mediated pneumonias (Adler, H. etal., J. Exp. Med. (1997), Vol. 185, pp. 1533-1540); trauma of various etiologies (Thomae, K.R. etal., Surgery(1996), Vol. 119, pp. 61-66); rheumatoid arthritis and 20 osteoarthritis (Grabowski. P.S. ef al., Br. J. Rheumatol. (1997), Vol. 36, pp. 651-655); glomerulonephritis (Weinberg, J.B. ef al., J. Exp. Med. (1994), Vol. 179, pp. 651-660); systemic lupus erythematosus (Belmont, H.M. ef al., Arthritis Rheum. (1997), Vol. 40, pp. 1810-1816); inflammatory bowel diseases such as ulcerative colitis and Crohn's disease (Godkin, A.J. ef al., Eur. J. Clin. Invest. (1996), Vol. 26, pp. 867-872; Singer, l.l.ef al., Gastroenterology (1996), Vol. 25 111, pp. 871-885); insulin dependent diabetes meilitus (McDaniel, M.L., ef al., Proc. Soc. Exp. Biol. Med. (1996), Vol. 211, pp. 24-32); diabetic neuropathy or nephropathy (Sugimoto, K. and Yagihashi, S., Microvasc. Res. (1997), Vol. 53, pp. 105-112; Amore, A. ef al., Kidney Int. (1997), Vol. 51, pp. 27-35); acute and chronic organ transplant rejection (Worrall, N.K. ef al., Transplantation (1997), Vol. 63, pp. 1095-1101); transplant vasculopathies (Russell, M.E. etal., 30 (1995), Vol. 92, pp. 457-464); graft-versus-host disease (Kichian, K. ef al., J. Immunol. (1996), Vol. 157, pp. 2851-2856); psoriasis and other inflammatory skin diseases (Bruch-Gerharz, D. ef al., J. Exp. Med. (1996), Vol. 184, pp. 2007-2012); and cancer (Thomsen, L.L. ef al., Cancer Res. (1997), Vol. 57, pp. 3300-3304). The compounds of the current invention may also be useful for the management of male 35 and female reproductive functions when used alone or combined with other drugs commonly used for these indications. Examples, without implied limitation, include: inhibition of fertilization, endometrial receptivity and implantation (alone or in combination with a progesterone antagonist); post-coital contraception (alone or in combination with a progesterone antagonist); WO 01/14371 PCT/US00/23173 induction of abortion (in combination with an antiprogestin and in further combination with a prostaglandin); control and management of labor and delivery; treatment of cervical incompetence (alone or in combination with progesterone or a progestin); treatment of endometriosis (alone or in combination with other drugs, including LHRH-agonists/antagonists, 5 antiprogestins orprogestins by either sequential application or by concomitant administration). See, for example, the following references: Chwalisz, K. ef al., J. Soc. Gynecol. Invest. (1997), Vol. 4, No. 1 (Supplement), page 104a, which discusses the inhibition of fertilization,, endometrial receptivity and implantation, or post-coital contraception, alone or in combination with a progesterone antagonist; Chwalisz, K. ef a/., Prenat. Neonat. Med. (1996), Vol. 1, pp. 292-329, 10 which discusses the induction of abortion, in combination with an antiprogestin and in. further combination with a prostaglandin, and the control and management of labor and delivery; and Chwalisz, K. era/., Hum. Reprod. (1997), vol. 12, pp. 101-109, which dismisses the treatment of cervical incompetence, alone or in combination with progesterone or a progestin. Those skilled in the art will also recognize that the compounds of the present invention 15 include 1-substituted imidazoles. This class of compounds has, previously been described as mechanism-based, heme-binding inhibitors of the cytochrome P450 family of enzymes (Maurice, M. ef al., FASEB J. (1992), Vol. 6, pp. 752-8) in addition to nitric oxide synthesis (Chabin, R.NM. ef al., Biochemistry (1996), Vol. 35, pp. 9567-9575). The compounds of the present invention may thus be useful as inhibitors of selected cytochrome P450 family members of therapeutic 20 interest including, but not limited to, P45Q enzymes involved in steroid and retinoid biosynthesis (Masamura ef al., Breast Cancer Res. Treat. (1995), Vol. 33, pp. 19-26; Swart, P. ef al., J. Clin. Endocrinol. Metab., Vol. 77, pp. 98-102; Docks, P. ef al., Br. J. Dermatol. (1995), Vol. 133, pp. 426-32) and cholesterol biosynthesis (Burton, P.M. ef al., Biochem. Pharmacol. (1995J, Vol. 50, pp. 529-544; and Swinney, D.C. ef al., Biochemistry (1994), Vol. 33, pp. 4702-4713). Imidazole- 25 based compounds may also have antifungal activity (Aoyama, Y. ef at., Biochem. Pharmacol. (1992), Vol.44, pp. 1701-1705). The P450 inhibitory activity of the compounds of the present invention can be assessed using appropriate assay systems specific for the P450 isoform of interest, Such assays are included in the references cited above. One additional example of mammalian cytochrome P450 isoform that may be inhibited by the compounds of the present 30 invention is cytochrome P450 3A4 which can be assayed in a manner similar to the method described in Yamazaki ef al., Carcinogenesis (1995), Vol. 16, pp. 2167^2170. Testing of the Compounds of the Invention Nitric oxide synthases are complex enzymes that catalyze the conversion of L-arginine to 35 nitric oxide (NO) and citrulline. Catalysis proceeds through two successive oxidations of the guanidinium group of L-arginine. A cell-based nitric oxide synthase assay employing the measurement of nitric oxide oxidation product, nitrite, in the conditioned medium of cultured cells was employed for the WO 01/14371 PCT/US00/23173 evaluation of the compounds of the invention. The murine monocytic cell lines RAW 264.7 and J774 are well documented as capable of producing >10 μM nitrite in response to immunostimulation: Induction of iNOS in RAW 264.7 Mouse Monocytes 5 RAW 264.7 murine macrophage cells were obtained from American Type Culture Collection (Rockviile, Maryland) and were maintained in RPM11640 containing 10% fetal bovine serum (FBS), 5000 units/mL of penicillin and streptomycin, and 2mM glutamine (maintenance medium). NOS activity was measured by a fluorescent assay of the nitric oxide oxidation product, nitrite, (Diamani er a/., Talanta (1986), Vol. 33, pp. 649-652). Induction of iNOS 68 10 (inducible nitric oxide synthase) is stimulated by treatrnent of the cells with lipopolysaccharide and Y-interferon. The method of the assay is described below. Cells are harvested, diluted to 500,000 cells/mL with.maintenance medium, and seeded into 96-well plates at 100 u.l/well. The plates are incubated overnight at 37"C, under a 5% C02 atmosphere. The medium is then replaced with 90 (il of BME medium containing 10% FBS, 100 15 units/mL of penicillin, 100 μ| streptomycin, 2 mM glutamine, 100 units/mL of interferon-y and 2 u.g/ml_ of lipopoly-saccharide. N-guanidino-methyl-L-arginine is added to four wells (negative control) at a final concentration of 200μM using 10 nl of 2 mM stock solution in 100 mM Hepes, pH 7.3 + 0.1% DMSO and four wells receive only the 100 mM Hepes/0.1% DMSO buffer (positive control). Compounds for evaluation are dissolved at 10-fold the desired final concentration in 20 Hepes/DMSO and 10μL of these solutions is transferred to the 96-well plate. The plates are incubated for 17 hrs at 37"C, under a 5% C02 atmosphere. Nitrite accumulated in the culture medium is determined as follows: add 15 ΜL of 2,3-diaminonaphthalene (10 fig/mL in 0.75 M HCI) to each well and incubate for 10 minutes at room temperature. Add 15 μl of 1 N NaOH and measure the fluorescence emission at 405 nm, using an excitation wavelength of 365 nm. 25 Enzyme activity in experimental wells is normalized to percent control using the positive and negative control values. The signal to noise ratio is >10 for the assay. The compounds of the invention, when tested in this assay, demonstrated the ability to inhibit nitric oxide production. Various in vivo assays may be employed to determine the efficacy of the compounds of 30 the invention in treating a condition resulting from an abnormality in nitric oxide production, such as arthritis. The following is a description of such an assay utilizing rats: Effects of Compounds of the Invention on Adjuvant-Induced Arthritis in Rats Male Lewis rats were injected intradermally (proximal quarter of the tail) with 0.1 mL of Mycobacterium butyricum in Incomplete Freund's Adjuvant (10 mg/mL). Either vehicle (acidified . 35 saline, 1 mL/kg) or a compound of the invention (3,10, or 30 mg/kg) were administered subcutaneously (b.i.d.), starting on the day following adjuvant immunization, and continued until the end of the experiment (N= 10 rats per treatment group). Clinical scores (see below) were measured in all limbs 3 times per week throughout the study. Rats were euthanized 34-35 days WO 01/14371 PCT/US00/23173 after immunization. At the time of euthanasia, a radiologic evaluation (see below) of the hind paws was performed, a blood sample was collected for clinical blood chemistry and drug levels (high dose group only; 6 or 12 hours post final dose), a section of liver was obtained for measurement of potential toxicity, and the hind limbs were preserved for histopathological 5 determination. Clinical scoring - each limb was graded according to the following scale: 0 no signs of inflammation 1 moderate redness, first indication of swelling, joint flexible 2 moderate redness, moderate swelling, joint flexible 10 3 redness, significant swelling and distortion of the paw, joint beginning to fuse 4 redness, gross swelling and distortion of the paw, joint completely fused Radiological scoring - each hind limb was graded on a scale of 0-3 for each of the 15 following parameters: soft tissue swelling cartilage loss erosion heterotropic ossification 20 The compounds of the invention, when tested in this assay, demonstrated the ability to treat the arthritis present in the rats. Those skilled in the art will also recognize that numerous assays for the activity of the NOS isoforms (iNOS, nNOS and eNOS) exist which can be used to evaluate the biological activity of the compounds of the current invention. These include assays for native NOS 25 isoforms in tissues studied ex vivo (Mitchell et al., Br. J. Pharmacol. (1991), Vol. 104, pp. 289-291; Szabo eta/., Br. J. Pharmacol. (1993), Vol. 108, pp. 786-792; Jply et al., Br. J. Pharmacol. (1995), Vol. 115, pp. 491-497) as well as primary cell cultures and cell lines (Forstermann etal., Eur. J. Pharmacol. (1992), Vol. 225, pp. 161-165; Radmoski etal., Cardiovasc. Res. (1993), Vol. 27, pp. 1380-1382; Wang etal., J. Pharmacol. Exp. Ther. (1994), Vol. 268, pp. 552-557). Those 30 skilled in the art will also recognize that recombinant NOS enzymes can be expressed in heterologous cells by either transient transfection (Karlsen ef al., Diabetes, (1995), Vol. 44, pp. 753-758), stable transfection (McMillan ef a/., Proc. Natl. Acad. Sci. (1992), Vol. 89, pp. 11141-11145; Sessa ef al., J. Biol. Chem. (1995), Vol. 270, pp. 17641-17644). or via the use of lytic virus transfection (Busconi & Michel, Mol. Pharmacol. (1995), Vol. 47, pp. 655-659; List ef al., 35 Biochem. J. (1996), Vol, 315, pp. 57-63) using NOS cDNAs. HeterbJopous expression can be achieved in mammalian cells (McMillan ef al., Proc. Natl. Acad. Sci. (1992), Vol. 89, pp. 11141-11145), insect cells (Busconi & Michel, Mol. Pharmacol. (1995), Vol. 47, pp. 655-659; List ef al., Biochem. J. (1996), Vol. 315, pp. 57-63), yeast (Sari ef al., Biochemistry (1996), Vol. 35, pp. WO 01/14371 PCT/US00/23173 7204-7213) or bacteria (Roman ef a/., Proc. Natl. Acad. Sci. (1995), Vol. 92, pp. 8428-8432; Martasek et a/., Biochem. Biophys. Res. Commun. (1996), Vol. 219, pp. 359-365). Any of these heterologous expression systems can be used to establish iNOS, nNOS and eNOS assay systems to evaluate the biological activity of the compounds of the present invention. 5 Administration of the Compounds of the Invention Any suitable route of administration may be employed for providing a patient with an effective dosage of compounds of the invention. For example, oral, rectal, parenteral (subcutaneous, intramuscular, intravenous), transdermal, and like forms of administration may be 10 employed. Dosage forms include tablets, troches, dispersions, suspensions, solutions, capsules, patches, and the like. The pharmaceutical compositions of the present invention comprise the compounds of the invention as the active ingredient, and may also contain a pharmaceutically acceptable carrier, and optionally, other therapeutic ingredients. Carriers such as starches, sugars, and 15 microcrystalline cellulose, diluents, granulating agents, lubricants, binders, disintegrating agents, and the like are suitable in the case of oral solid preparations (such as powders, capsules, and tablets), and oral solid preparations are preferred over the oral liquid preparations. Methods for their preparation are well known in the art. Because of their ease of administration, tablets and capsules represent the most 20 advantageous oral dosage unit forms, in which case solid pharmaceutical carriers are employed. If desired, tablets may be coated by standard aqueous or nonaqueous techniques. In addition to the common dosage forms set out above, the compounds of the present invention may also be administered by controlled or sustained release means and delivery devices. Pharmaceutical compositions of the present invention suitable for oral administration may 25 be presented as discrete units such as capsules, cachets, or tablets, each containing a predetermined amount of the active ingredient, as a powder or granules, or as a solution or a suspension in an aqueous liquid, a non-aqueous liquid, an oil-in-water emulsion, or a water-in-oil liquid emulsion. Such compositions may be prepared by any of the methods of pharmacy, but all methods include the step of bringing into association the active ingredient with the carrier which 30 constitutes one or more necessary ingredients. In general, the compositions are prepared by uniformly and intimately admixing the active ingredient with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product into the desired presentation. Preferred Embodiments 35 Of the compounds of formula (Ya), formula (Yb) and formula (Yc) as described above in the Summary of the invention, a preferred group of compounds are those compounds having the formula (Yc) wherein n is 1; m is 2 or 3; A is -C(0)OR2 or -C(0)N(R')R2; each W is CH; R1 is hydrogen or alkyl; and R2 is hydrogen, alkyl, -(CH)n-N(R1)2, optionally substituted WO 01/14371 PCT/USOO/23173 heterocyclylalkyl or optionally substituted aralkyl. Of this subgroup of compounds, a preferred class of compounds are those compounds . wherein R4 is -N(R1)R2 where R1 is hydrogen or alkyl and R2 is heterocyclylalkyl selected from the group consisting of (1,3-benzodioxol-5-yl)methyi or (1,4-benzodioxan-6-yl)methyl. 5 Of this class of compounds, preferred compounds are selected from the group consisting of: 2-[[3-[[(1,3-benzodioxol-5-yl)methyl](methyl)amino]propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin- 4-yl]amino]acetic acid, ethyl ester; 2-[[3-[[(i,3-benzodioxol-5-yl)methyl](methyl)amino]propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin- 10 4-yl]amino]-N,N-diethylacetamide; 2-[[3-[[(1,3-benzodioxol-5-yl)methyl](methyl)amino]propyl][2-(1W-imida2ol-1-yl)-6-methylpyrimidin-4-yl]amino]-A/-(2-dimethylaminoethyl)acetamide; 2-[[3-i[(1,3-benzodioxol-5-yl)methyl](methyl)amino]propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin- 4-yl]amino]acetamide; 15 2-[[3-[(1,3-benzodioxol-5-yl)methyl]aminopropyl][2-(l H-imidazol-1-yl)-6-methylpyrimidin-4- yl]amino]-N,N-diethylacetamide; 2-[[3-[(1,3-benzodioxol-5-yl)rnethyl]aminopropyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4- yl]amino]-N-methylacetamide; 2-[[3-[(1,4-benzodioxan-6-yl)methyl]aminopropyl][2-(1 H-imidazol-1 -yl)-6-methyipyrimidin-4- 20 yl]amino]-A/-methylacetamide; 2-[[3-t(1.4-benzodioxan-6-yl)methyl]aminopropyli[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4- yl]amino]-N,N-diethylacetamide; 2-[[3-{(1,4-benzodioxan-6-yl)methyl]aminopropyl][2-(1H-imidazol-1-yl)-6'methylpyrimidin-4- yl]amino]acetamide; and 25 2-[[3-[(1,3-benzodioxol-5-yl)methyl]aminopropyl][2-( 1 H-imidazol-1 -yl)-6-methylpyrimidin-4- yl]amino]acetamide. Of the preferred subgroup of compounds, a preferred class of compounds are those compounds wherein R4 is heterocyclyl. Of this class of compounds, preferred compounds are selected from the group consisting 30 of: 2-[[pyridin-3-ylmethyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3-benzodioxol- 5-yl)ethyl]acetamide; 2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl][(1,3-benzodioxol-5-yl)methyl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide; and 35 2-[[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl][2-(morpholin-4-yl)ethyl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide. Of this subgroup of compounds, another preferred class of compounds are those compounds wherein R4 is hydroxy, cyano, -N(R1)R2, -N(R1)-C(0)-R1, -N(R1)-C(0)OR1, -N(R1)- WO 01/14371 PCT/US00/23173 S(0)1-R\ or -N(R1)-C(0)-N(R1)2' where each R1 and each R2 is independently hydrogen, alkyl or aralkyl. Of this class of compounds, preferred compounds are selected from the group consisting of: 5 2'[[3-hydroxypropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yi]amino]-N-[2-(1,3-benzodioxol-5- yl)ethyl]acetamide; 2-[[2-cyanoethyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3-benzodioxol-5- yOethylJacetamide; 2-t(3-(dimethylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3- 10 benzodioxol-5-y!)ethyl]acetamide; 2-[[3-(acetylamino)propy(][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-(2-(1,3- benzodioxol-5-yl)ethyl]acetamide; 2-[[3-(methylsulfonylamino)propy!][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide; 15 2-t[3-(methoxycarbonylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2- (1,3-benzodioxol-5-yl)ethyl]acetamide; 2-p-(phenylmethylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino3-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide; 2-[[3-aminopropyl][2-(1 H-imidazoM -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3-benzodioxol-5- 20 yl)ethyl]acetamide; 24[3-aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4- methoxyphenyl)ethyl]acetarnide; 2-[[3-(methylsulfonylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; 25 2-[[3-(methoxycarbonylamino)propyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; 2-[[3-(phenylmethylamino)propyl](2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; 2-[[3-(acetylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4- 30 methoxyphenyl)ethy!]acetamide; 2-[[3-aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,4-benzodioxan-6- yl)ethyl]acetamide; 2-[[3-(methoxycarbonylamino)propyl][2-(1H-imidazol-1-yi)-6-methylpyrimidin-4-yl]amino]-N-[2- (1,4-benzodioxan-6-yl)ethyi]acqtamide; 35 2-[[3-(di(phenylmethyl)amino)propyl][2-( 1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2- (1,4-benzodioxan-6-yl)ethyl]acetamide; 2-[[3-(acetylamino)propyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,4- benzodioxan-6-yl)ethyi]acetamide; WO 01/14371 PCT/US00/23173 2-[[3-(methylsulfonylamino}propyl][2-(1H-imidazol-1-yl)-6-methyipyrimidin-4-yi]amino]-N-[2-(1,4- benzodioxan-6-yl)ethyl]acetamide; 2-[[3-(dimethylamino)propyl][2-(1H-imidazol-1-yl)-6-rnethylpyrimidin-4-yl]amino]-N-[2-(1,4- benzodioxan-6-yl)ethyl]acetamide; 5 2-[[3-(dimethylamino)propyl](2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino3-N-[2-(4- methoxyphenyl)ethyl]acetamide; 2-[[3-(ureido)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; 2-[[3-(prienylmethylamino)propylH2-(1H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,4- 10 benzodioxan-6-yl)ethyl]acetamide; 2-[[3-(phenyfmethylamino)propyf][2-(1H'midazo(-1-yI)-6-methy(pyrimidin-4-yl]amino]-N[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; 2-[[3-aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; 15 2-[[3-(dimethylamino)propyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; 2-[[3-(acetylamino)propyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; 2-[[3-(methoxycarbonylaminO)propyl][2-(1H-imidazol-1-y!)-6-methylpyrrmidin-4-yl]amino]-N[2- 20 (2,3-dihydrobenzofuran-5-yi)ethyl]acetamide; 2-[[3methylsulfonylamino)propyl][2-(1H-imidazol-1-yl)-6-methyipyrimidin-4-yl]amino]-N-[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; 2-[[3-(ureido)propyl][2-(1H-nriidazol-1-yl)-6-methylpyrimidin-4-yl]arnino]-A/-[2-(1l4-benzodioxari-6- yl)ethyl]acetamide; and 25 2-[t3-(ureido)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide. Preparation of the Compounds of the Invention Reaction Scheme$ 1 through 4 depict methods of preparing compounds of formula (Yc). 30 Compounds of formula (Ya) and formula (Yc) may be similarly prepared: WO 01/14371 PCT/US00/23173 WO 01/14371 PCT/US00/23173 Compounds of formulae (Y1,), (Y2), (Y4) and (Y5) are commercially available or may be prepared by methods disclosed herein or by methods known to those of ordinary skill in the art. Each R1, R2, m and n are independently as described above in the Summary of the Invention for 5 con- inds of formula (Ya), formula (Yb) and formula (Yc); and R5 and W are also as described abow .1 the Summary of the Invention for compounds of formula (Ya), formula (Yb) and formula (Yc). The above synthesis may be carried out as follows: To A/-cyanoethylglycine, ethyl ester (15.9 g, 102 mmol) (a compound of formula (Y2)) 10 dissolved in DMSO (70 mL) was added 4-chloro-6-methyl-2-methylsulfonylpyrimidine (18 91 mmol) (a compound of formula (Y,)) and diisopropylethylamine (18 mL, 100 mmol). Afte :ng for 16 hours, the reaction temperature was raised to 70°C and imidazole (26.5 g, 0.39 mol) was added. After stirring for 1 day, the^eaction was cooled to ambient temperature and added to ice water. The solid that formed was suction filtered and collected on paper to give 9.9 g of 2-[(2-15 cyanoethyl)[2-(1Himidazol-1-yl)-6-methylpyrimidin-4-yl]amino]acetic acid, ethyl ester (a compound of formula (Yc1)). To 2-[(2-cyanoethyl)[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]acetic acid, ethyl ester (4.51 g, 14.4 mmol) dissolved in THF (250 mL) was added LiOH (0,91 g, 21.7 mmol) and water (30 mL). After stirring for 18 hours, most of the solvent was removed in vacuo and 1 N HCI 20 (21.7 mL, 21.7 mmol) was added. The solid that formed was suction filtered and collected on paper to give 3.17 g of 2-[(2-cyanoethyl)[2-(1 H-imidazol-1 :yl)-6-methylpyrimidin-4-yl]amino]acetic . acid (a compound of formula (Yc2)). To2-[(2-cyanoethyl)[2-(1W-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]acetic acid (1.53 , g, 5.3 mmol) slurried in DMF (25 mL) was added carbonyldiimidazole (0.87 g, 5.4 mmol). After 25 stirring for 2 hours, diethylamine (1.0 mL, 9.7 mmol) (a compound offormula (Y4)) was added. After stirring for 18 hours, the reaction was partitioned with ethyl acetate and water. The organic layer was separated, dried (Na2S04), and the solvent was removed in vacuo to give 0.91 g of 2- [(2-cyanoethyl)[2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N,N-diethylacetamide (a compound of formula (Yc3)). 30 The following compounds of formula (Yc3) and derivatives thereof were prepared in a similar manner with the appropriately substituted starting materials: 2-((2-cyanoethyl)[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-methylacetamide; 2-[(2-cyanoethyl)(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(l,4-benzodioxan-6- yl)ethyl]acetamide. 35 Ammonia (g) was bubbled into 2-[(2-cyanoethyl)[2-(1H-imidazol-1-yl)-6-methylpyrimidin- 4-yl]amino]-N,N-diethylacetamide (0.22 g, 0.65 mmol) dissolved in MeOH (25 mL). Raney Nickel (0.8 g) was added and the mixture was placed under nitrogen at 50 psi. When the reaction was determined to be complete by TLC, the reaction mixture was suction filtered through celite and WO 01714371 PCT/US00/23173 the solvent was removed in vacuo. To the residue dissolved in MeOH (10 mL) was added piperonal (0.29 g, 1.9 mmol) and NaBH(OAc)3 (0.40 g, 1.9 mmol). After stirring for 18 hours, the solvent was evaporated and the residue was partitioned between ethyl acetate and aqueous bicarbonate solution. The organic layer was separated, dried (Na2S04), and the solvent was 5 removed in vacuo. Chromatography on silica with acetonitrile/ammonium hydroxide (19/1) gave 2-[[3-[(1,3-benzodioxol-5-yl)methyl]aminopropyl][2-(1H-imidazol-1-yl)-6-methyipyrimidin-4- yl]amino]-W,A/-diethylacetamide, a compound of formula (Yc4); NMR (CDCI3) 8.4 (s, 1), 7.65 (s, 1), 7.0 (s, 1), 6.85 (s, 1), 6.75 (d, 1), 6.5 (d, 1), 6.05 (br, 1), 5.85 (s, 2), 4.3 (s, 2), 3.85 (s, 2), 3.65 (br, 2), 3.4 (m, 4), 2.95 (t, 2), 2.3 (s, 3), 2.2 (m, 2), 1.25 (t, 3), 1.1 (t, 3) ppm. 10 The following compounds of formula (Yc4) and derivatives thereof were prepared in a similar manner with appropriately substituted starting materials: 2-[[3-[(1,4-benzodioxan-6-yl)methyl]aminopropyl.][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4- yl]amino]-N-methyiacetamide; NMR (CDCI3) 8.5 (s, 1), 7.8 (s, i), 7.1 (s, 1), 6.75 (m, 3), 6.25 (br, 1), 4.25 (s. 4), 4.15 (br, 2), 3.7 (s, 2), 3.6 (s, 2), 2.8 (d, 3), 2.75 (m, 2), 2.4 (s, 3), 15 1.85 (m, 2) ppm; 2-[[3-[(1,3-benzodioxol-5-yl)methyl]aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4- yl]amino]-/V-methylacetamide; NMR (DMSO-d6) 8.4 (s, 1), 8.0 (m, 1), 7.8 (s, 1), 7.05 (s, 1), 6.9 (s, 1), 6.8 (m, 2), 6.65 (s, 1), 6.3 (br, 1), 5.95 (s, 2). 4.1 (br, 2), 3.6 (s, 2), 3.55 (br, 2), 3.3 (br, 3). 2.6 (m, 2), 2.3 (s, 3). 1.75 (m, 2) ppm; 20 2-[[3-[(1,4-benzodioxan-6-yl)methyl]aminopropyl]{2-(1H-imidazoI-1-yl)-6-methylpyrimidin-4- yl]amino]-N,N-diethylacetamide; NMR (CDCI3) 8.4 (s, 1), 7.7 (s, 1), 7.05 (s, 1), 6.85 (s, 1), 6.6 (m, 2), 6.3 (br, 1), 4.4 (s, 2), 4.25 (s, 4), 3.7 (s, 2), 3.6 (m, 2), 3.4 (q, 4), 2.7 (t, 2), 2.35 (s, 3), 1.9 (m, 2), 1.35 (t, 3), 1.15 (t, 3) ppm; 2-[[3-[(1-,4-benzodioxan-6-yl)methyl]aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4- 25 yt]amino]acetamide; NMR (CDCI3) 8.5 (s, 1), 7.8 (s, 1), 7.1 (s, 1), 6.75 (m, 3), 6.3 (br, 1), 6.0 (br, 1), 4.2 (s, 4), 4.15 (s, 2), 3.65 (m, 4), 2.75 (m, 2), 2.4 (s, 3), 1.85 (m, 2) ppm; 2-Q3-[(1,3-benzodioxol-5-yl)methyl]aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4- yl]amino]acetamide; NMR (CDCI3) 8.5 (s, 1), 7.75 (s, 1), 7.05 (s, 1), 6.75 (m, 3), 6.3 (br, 1), 5.95 (s, 2), 5.4 (br, 1), 4.15 (s, 2), 3.7 (br, 2), 3.6 (s, 2), 2.75 (t, 2), 2.4 (s, 3), 1.85 (m, 30 2) ppm. Compounds of formula (Y4) wherein R2 is 2-(1,4-benzodioxan-6-yl)ethyl may be prepared as follows and reacted with the compound of formula (Yc2) to prepare compounds of formula (Yc3), which may be further reacted as described above to form compounds of formula (Yc4): To 1,4-benzodioxane-6-carboxaldehyde (10.0 g, 60 mmol) in acetic acid (50 mL) was 35 added nitromethane (6.3 mL, 1.9 eq.) and ammonium acetate (5.1 g, 1.1 eq.). After heating at 110°C for 4 hours the mixture was cooled to ambient temperature, water (150 mL) was added, and the solid precipitate was collected by filtration. The solid was crystallized from methylene chloride-hexane (1:1, 45 mL) to obtain 7.6 g (61 %) of 6-(2-nitroe.thenyl)-1,4-benzodioxane. To a WO 01/14371 PCT/US00/23173 POrtion of the solid (3.58 g) dissolved in MeOH-EtOH-AcOEt (1:1:1, 450 mL) was added 10% p3d/C (t.7 g) and concentrated HCI (3.3 mL, 2.3 eq). After shaking on a Parr hydrogenator at 45 psi for 5 hours, the catalyst was removed by filtration through Ceiite and washed with methanol. Evaporation of the filtrate gave 3.59 g (96%) of 1,4-benzodioxan-6-ethanamine, hydrochloride. 5 Alternatively, compounds of formula (Y3) may be'reacted as follows to form compounds of formula (Yc3) wherein R1 and Rz are both hydrogen, which may be further reacted with a compound of formula (Y5) to form compounds of formula (Yc4): To 2-[(2-cyanoethyl)[2-(1H-imida2ol-1-yl)-6-methylpyrimidin~4-yl]amino]acetic acid, ethyl ester (2.3 g, 7.3 mmol) slurried in MeOH (50 mL) and cooled in a dry ice/acetone bath was 10 bubbled NH3. The bomb was sealed and heated in an oil bath at 65°C for 2 days. The reaction was cooled in a dry ice/acetone bath and the seal-was broken. The solid was suction filtered to give 1.7 g of 2-[(2-cyanoethyl)[2-(1H-imidazol-1-yl)"6-methylpyrimidin-4-yl]amino]acetamide. Reaction Scheme 2 depicts another method of preparing compounds of formula (Yc). Compounds of formula (Ya) and formula (Yb) may be similarly prepared: WO 01/14371 PCT/US00/23173 Compounds of formulae .(Y,), (Y6), (Y7), (Y9) and (Y5) are commercially available or may be prepared by methods disclosed herein or by methods known to those of ordinary skill in the art. Each R', R2, m and n are independently as described above in the Summary of the Invention for compounds of formula (Ya), formula (Yb) and formula (Yc); and R4, R5 and W are also as described above in the Summary of the Invention for compounds of formula (Ya), formula (Yb) and formula (Yc). WO 01/14371 PCT/USOO/23173 The above synthesis may be carried out as follows: To homopiperonylamine hydrochloride (2.14 g, 10.6 mmol) (a compound of formula (Y7)) in CH2CI2 (20 mL) in an ice bath was added triethylamine (3.1 mL, 21 mmol) and chloroacetyl chloride (0.85 mL, 10 mmol) (a compound of formula (Y6)). After wanning to ambient 5 temperature and stirring for 16 hours, the reaction was partitioned with 1 N HCI. The organic layer was separated, washed with aqueous bicarbonate, dried (Na2S04), and the solvent was removed in vacuo to give 1.8 g of 2-chloro-N-(2-(1,3-benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Y8). To 2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide (0.45 g, 1.9 mmol) in ethanol (10 10 mL) was added 3-aminopropanol (0.72 mL, 9.4 mmol) (a compound of formula (Y9)). After heating the reaction in an oil bath at 60°C for 1 day, the reaction was partitioned with ethyl acetate and water. The organic layer was separated, washed with brine, dried (Na2S04), and the solvent was removed in vacuo to give 0.44 g of 2-[(3-hydroxypropyl)amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Y10)- 15 The following compounds of formula (Y10) were prepared in a similar manner from the appropriately substituted starting materials: 2-[(3-pyridinylmethyl)amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide; 2-[[2-(4-morpholinyl)ethyl]amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide; 2-[(1,3~benzodioxol-5-ylmethyl)amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide. 20 To 2-[(3-hydroxypropyl)amino]-N/-(1,3-benzodioxolr5-ylmethyl)acetamide (0.44 g, 1.6 mmol) dissolved in DMSO (5 mL) was added 4-chloro-6-methyl-2-methyisulfonylpyrimidine (0.31 g, 1.5 mmol) (a compound of formula (Y,) and diisopropylethylamine (0.55 mL, 3.1 mmol). After stirring for 16 hours, the reaction temperature was raised to 70PC and imidazole (0.47"g, 6.9 mol) was added. After stirring for 1 day, the reaction was cooled to ambient temperature and 25 partitioned with water and ethyl acetate. The organic layer is separated, dried (Na2S04), and the solvent was removed in vacuo. Chromatography on silica with CH2CI2/MeOH gave 2-[[3-hydroxypropyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-/V-[2-(1,3-benzodioxol-5-yl)ethyi]acetamide, a compound of formula (Yc5). The following compounds of formula (Yc5) and derivatives thereof were prepared in a 30 similar manner with the appropriately substituted starting materials: 2-[[pyridin-3-ylmethyi][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3-benzodioxol- 5-yl)ethyl]acetamide; NMR (CDCI3)8.6 (s, 1), 8.45 (s, 2), 8.15 (t, 1), 7.8 (s, 1), 7.7 (d, 1), 7.35 (br, 1), 7.05 (s, 1), 6.8 (br, 2), 6.6 (br, 2), 6.0 (s, 2), 4.8 (m, 2), 4.2 (m, 2), 3.3 (m, 2), 2.6 (m, 2), 2.3 (s, 3) ppm; 35 2-[[2-cyanoethyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin'4-yl]amino]^N-[2-(1,3-benzodioxol-5- yl)ethyl]acetamide; NMR(CDCI3) 8.5 (s, 1), 7.8 (s, 1), 7.1 (s, 1), 6.6 (d, 1), 6.55 (d, 1), 6.3 (t, 1), 6.2 (s, 1), 5.9 (s, 2), 4.2 (s, 2), 3.9 (t, 2), 3.55 (t, 2). 2.8 (t, 2), 2.75 (t, 2), 2.45 (s, 3) ppm; WO 01/14371 PCT/US00/23173 2-[t3-[[(1l3-ben2odioxol-5-yl)methyl](methyl)amino]propyl][2-(1H-imida20l-1-yl)-6-methylpyrirnidin-4-yl]amino]acetic acid, ethyl ester; NMR (CDCI3) 8.5 (s, 1), 7.8 (s, 1), 7.05 (s, 1), 6.85 (s, 1), 6.75 (m, 2), 6.4 (br, 1), 5.9 (s, 2), 4.2 (m, 4), 3.6 (m, 2), 3.4 (s, 2), 2.4 (t, 2), 2.35 (s, 3), 2.2 (s, 3), 1.9 (t, 3), 1.2 (t, 3) ppm; 5 2-[[2-(1H-imida2ol-1-yl)-6-methylpyrimidin-4-yl][2-(rnorpholin-4-yl)ethyl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide; NMR (CDCI3) 8.5 (s, 1), 7.8 (s, 1), 7.1 (s, 1), 6.5 (d, 1), 6.3 (br, 1), 6.15 (s, 2), 5.7 (br, 2), 4.0 (m, 4), 3.45 (m, 8), 2.6 (m, 2), 2.4 (s, 3), 2.35 (m, 4) ppm; and 2-[[2-(1H-imida2ol-1-yl)-6-rnethylpyrirnidin-4-yl][(1,3-benzodioxol-5-yl)methyl]arnino]-N-[2-(1,3- 10 benzodioxol-5-yl)ethyl]acetamide; NMR (CDCI3) 8.75 (s, 1), 8,15 (t, 1), 7.8 (s, 1), 7.15 (s, 1), 6.75 (d, 1), 6.7 (m, 2). 6.55 (d, 1), 6.4 (m, 2), 6.2 (br, 1), 6.0 (s, 2), 5.9 (s, 2), 4.65 (br, 2), 4.1 (br, 2), 3.4 (m, 2), 2.3 (s, 3) ppm. Alternatively, compounds of formula (Y10) and derivatives thereof are prepared as follows: 15 In a manner similar to the preparation of compounds of formula (Yc3) above, to 2-[(2- cyanoethyl)(dimethylethoxycarbonyl)amino]acetic acid (8.3 g, 39 mmol) dissolved in CH2CI2 (100 mL) was added carbonyldiimida20le (6.2 g, 38 mmol). After stirring for 30 minutes, homopiperonylamine, hydrochloride (8.0 g, 41 mmol) and diisopropylethylamine (7.5 mL, 43 mmol) were added. After stirring for 18 hours, most of the solvent was removed in vacuo and the 20 residue was partitioned with ethyl acetate and 1N HCI. The organic layer was separated, washed with aqueous bicarbonate and brine, dried (Na2S04), and the solvent was removed in vacuo to give 13 g of 2-[(2-cyanoethyl)(dimethylethoxycarbonyl)amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide. To 2-[(2-cyanoethyl)(dimethylethoxycarbonyl)amino]-N-[2-(1,3-benzodioxol-5-25 yl)ethyl]acetamide (f4 g, 37 mmol) in CH2CIZ (75 mL) cooled in an ice bath was added trifluoroacetic acid (50 mL). After stirring for 1 hour the ice bath was removed and the solvent was removed in vacuo. The residue was triturated with ether and a solid formed. The solid was collected by filtration to give 12 g of 2-[(2-cyanoethyl)amino]-N-[2-(1,3-benzodioxol-5- yl)ethyl]acetamide, trifluoroacetic acid salt, a compound of formula (Y10). 30 Alternatively, compounds of formula (Y10) and derivatives thereof are prepared as follows: To rV-methyl-8-alaninenitrile (50 g, mmol in acetonitrile was added piperonyf chloride (50 g, mmol). After stirring for 18 h, the solvent was removed in vacuo. The residue was dissolved in CH2CI2, washed with aqueous carbonate, dried (MgS04), and the solvent was removed in vacuo. 35 The residue was dissolved in methanol saturated with ammonia (600 mL) and Raney nickel (10 g) was added. After shaking under an atmosphere of hydrogen at 20 psi for 6 h, the reaction was . filtered through celite and the solvent was removed in vacuo to give 65 g of A/-(1,3-benzodioxol-5-ylmethyl)-N-methyl-1,3-propanediamine. WO 01/14371 PCT/USOO/23173 ToN-(1,3-benzodioxol-5-ylmethyl)-N-methyl-1,3-propanediamine (33 g, 0.15 mol) in CH2CI2 (500 mL) was added ethyl glyoxalate (30 mL of a 50% toluene solution, 0.15 mol) and sodium triacetoxyborohydride (40 g, 0.19 mol). After stirring for 4 hours, the reaction was washed with aqueous potassium carbonate and the solvent removed in vacuo. Chromatography 5 on silica with CH2CI2/ MeOH/ ammonium hydroxide gave 14 g of 2-[[3-[(1,3-benzodioxol-5-y!methyl)amino]propyl]amino]acetic acid, ethyl ester, a compound of formula (Y10). Reaction Scheme 3 depicts another method of preparing compounds of formula (Yc). Compounds of formula (Ya) and formula (Yb) may be similarly prepared with the appropriately substituted starting materials. 10 Reaction Scheme 3 WO 01/14371 PCIYUS00/23173 10 Compounds of formulae (Yc3) are prepared by methods disclosed herein. Each R\ R2, m and n are independently as described above in the Summary of the Invention for compounds of formula (Ya), formula (Yb) and formula (Yc); and R5 and W are also as described above in the Summary of the Invention for compounds of formula (Ya). formula (Yb) and formula (Yc). The above synthesis may be carried out as follows: To 2-[(2-cyanoethyl)[2-(1 H-imidazol-1 -yl)-6-methylpyn'midin-4-yl]amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide (2.5 g, 5.8 mmol) (a compound of formula (Yc3)) in MeOH (50 mL) was bubbled ammonia. Raney nickel (1.0 g of a 50 % slurry) was added and the reaction WO 01/14371 PCT/USOO/23173 was placed on a Parr hydrogenator at 50 psi. After shaking for 16 hours, the pressure was released and the reaction mixture was suction filtered through Celite. The solvent was removed in vacuo and the residue was chromatographed on silica gel (9:1 CH3CN/NH4OH) to afford 2~[[3-aminopropyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3-benzodioxol-5-5 yl)ethyl]acetamide, a compound of formula (Yc6); as a white solid; NMR (DMSO-d6, 90°C) 8.4 (s, 1), 7.8 (s, 1), 7.0 (s, 1), 6.75 (d, 1), 6.7 (s, 1), 6.6 (d. 1), 5.9 (s, 2), 4.1 (s, 2), 3.6 (br, 2), 3.3 (m, 2), 2.75 (t 2), 2.6 (t, 2), 2.3 (s. 3), 1.8 (m, 2) ppm. The following compounds of formula (Yc6) and derivatives thereof were prepared in a similar manner with appropriately substituted starting materials: 10 2-[[3-aminopropyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; NMR (DMSO-d6, 90 C) 8.4 (s, 1), 7.8 (s, 1), 7.05 (m, 3), 6.75 (d, 2), 6.45 (s, 1), 4.1 (s, 2), 3.7 (s, 3), 3.55 (t, 2), 3.3 (m, 2), 3.2 (s, 2), 3.6 (m, 4), 2.3 (s, 3) ppm; 2-([3-aminopropyl]t2-(1H-imidazol-1-yl)-6-methyipyrimidin-4-yl]amino]-/V-[2-(1,4-benzodioxan-6- 15 yl)ethyl]acetamide; NMR (DMSO-d6) 8.42 (br, 1}, 8.08 (br, 1), 7.80 (br, 1), 7.02 (s, 1), 6.65 (m, 4), 4.16 (m, 6), 4.05 (br, 1), 3.65 (br, 1), 3.45 (br, 2), 3.15 (br, 2), 2.59 (m, 4), 2.35 (s, 3), 1.62 (m, 2) ppm; and 2-[[3-aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-{2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; NMR (CDCI3) 8,46 (s, 1), 7.75 (s, 1), 7.06 (s, 1), 20 6.80 (s, 1), 6.70 (d, 1), 6.52 (d, 1), 6.18 (br, 1), 4.46 (t, 2), 4.06 ( br, 2), 3.60 (br, 2), 3.45 (m, 2), 3.05 (m, 2), 2.78 (br, 2), 2.65 (m, 2), 2.39 (s, 3), 1.70 (br, 4) ppm. Compounds of formula (Yc6) may be used to prepare compounds of formula (Yc7), (Yc8) and (Yc9) as set forth below: To 2-[(3-aminopropyl)[2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-I2-(1,3-25 benzodioxol-5-yl)ethyl]acetamide (0.3 g, 0.7 mmol) (a compound of formula (Yc6)) dissolved in MeOH (10 mL) was added formalin (0.15 mL. 2.0 mmol) and sodium triacetoxyborohydride (0.37 g, 1.7 mmol). After stirring for 16 hours, the solvent was removed in vacuo. The residue was partitioned with ethyl acetate and aqueous bicarbonate. The organic layer was separated, washed with brine, dried (Na2S04), and the solvent was removed in vacuo. Chromatography on r 30 silica with acetonitrile/ammonium hydroxide gave 0.14 g of 2-[[3-(dimethylamino)propyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Yc8); NMR (CDCI3)8.5 (s, 1), 7.8 (s, 1), 7.1 (s, 1), 6.5 (d, 1), 6.45 (s, 2), 6.4 (d, 1), 6.2 (m, 1), 5.9 (s, 2), 4.15 (s, 2), 3.55 (m, 2), 3.5 (q, 2), 2.6 (t, 2,), 2.4 (s, 3), 2.3 (t, 2), 2.25 (s, 6), 1.7 (m, 2) ppm. 35 To 2-[(3-aminopropyl)[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide (50 mg, 0.11 mmol) (a compound of formula (Yc6)) in methanol (2 mL) was added benzaldehyde (0.2 M in methanol, 68 μL, 0.14 mmol). After stirring for 15 minutes, borane-pyridine complex (0.2 M in methanol, 0.14 mmol) was added. After 2 hours, the WO 01/14371 PCT/US00/23173 solution was evaporated. The residue was partitioned into water and ethyl acetate. The aqueous layer was extracted twice with ethyl acetate. The combined ethyl acetate fractions were washed with brine, dried over sodium sulfate and concentrated. The residue was purified by chromatography on silica gel (2:1 ethyl acetate/hexanes) to provide 2-[[3-5 (phenylmethylamino)propyl][2-(1 H-imidazol-1-yl)-6-methylpyrimidin-4-yl]aminoJ-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Yc8); as a white solid; NMR (CDCI3) 8.65 (s, 1), 7.7 (s, 1), 7.2 (br, 5), 7.1 (s, 1), 6.6 (d, 1), 6.55 (s, 1), 6.5 (d, 1), 6.1 (br, 2), 5.9 (s, 2), 3.95 (br, 2), 3.5 (br, 6), 2.7 (m, 3), 2.35 (s, 6) ppm. The following compounds of formula (Yc8) and derivatives thereof were prepared in a 10 similar manner with appropriately substituted starting materials: 2-[[3-(phenylmethylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; NMR (CDCI3) 8.45 (s, 1), 7.75 (s, 1), 7.2 (br, 5), 7.05 (s, 1), 6.9 (d, 2). 6.65 (d, 2), 6.4 (br, 1), 4.1 (s, 2), 3.75 (s, 2), 3.7 (s, 3), 3.6 (br, 2), 3.45 (dd, 2), 2.7 (m, 4), 2.35 (s. 3), 1.8 (s. 2) ppm; 15 2-[[3-(dimethylamino)propyl][2-(1 H-tmidazol-1 -yl)-6-methylpyrirnidin-4-yl]arnino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; NMR (CDCI3) 8.45 (s, 1), 7.75 (s, 1), 7.05 (s, 1), 6.85 (d, 2), 6.6 (d, 2), 6.3 (br, 1), 6.25 (br, 1), 4.1 (s, 2), 3.7 (s, 3), 3.5(m, 4), 2.7 (t, 2), 2.4 (s, 3), 2.3 (t, 2), 2.2 (s, 6), 1.75 (m, 2) ppm; . 2-[[3-(di(phenylmethyl)amino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2- 20 (1,4-benzodioxan-6-yl)ethyl]acetamide; NMR (CDCI3) 8.45 (s, 1), 7.70 (s, 1), 7.35 (m, 10), 7.04 (s, 1), 6.62 (d, 1), 6.45 (s, 1), 6.40 (d. 1), 6.06 (br. 1), 5.96 (br, 1), 4.15 (br, 4), 3.92 (br, 2), 3.60 (s, 4), 3.45 (m, 4), 2.62 (t, 2), 2.50 (t, 2), 2.30 (s, 3), 1.72 (m, 2) ppm; 2-[[3-(phenylmethylamino)propyl][2-( 1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-( 1,4- benzodioxan-6-yl)ethyl]acetamide; NMR (CDCI3) 8.45 (s, 1), 7.75 (s, 1), 7.25 ( m, 6), 7.05 25 ( s, 1), 6.60 (d, 1), 6.45 (s, 1), 6.40 (d,"l), 6.20 (br, 1). 4.10 ( m, 6), 3.70 (br, 4), 3.40 (m, 2), 2.65 (t, 2), 2.60 (t, 2), 2.40 (s, 3), 1.90 (br, 1)', 1.76 (m, 2) ppm; 2-[[3-(dimethylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,4- benzodioxan-6-yl)ethyl]acetamide; NMR (CDCI3) 8.45 (s, 1), 7.75 (s, 1), 7.05 (s, 1), 6.65 ( d, 1), 6.50 (s. 1), 6.42 (s, 1), 6.30 (t, 1), 6.16 (br, 1), 4.12 ( m, 6), 3.50 (m, 4), 2.75 (m. 2), 30 2.62 (t, 2), 2.56 (s, 6), 2.40 (s, 3), 2.10 (m, 2) ppm; 2-[[3-(phenylmethylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-,[2-(2,3-dihydrobenzofuran-5-yl)ethyl]acetamide; NMR (CDCI3) 8.46 (s, 1), 7.75 (s, 1), 7.30 (m, 6). 7.10 (s, 1), 6.82 (s, 1), 6.68 (d, 1), 6.54 (d, 1), 6.25 (br, 1), 4.46 (t, 2), 4.10 (br, 2), 3.70 (br, 2), 3.62 (br, 2), 3.45 (m, 2), 3.05 (t, 2), 2.65 (m, 4), 2.40 (s, 3), 1.78 (m, 2) ppm; and 35 2-[[3-(dimethylamino)propyl][2-(1HHmidazol'1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; NMR (CDCI3) 8.45 (s, 1), 7.76 (s, 1), 7.06 (s, 1), 6.85 (s, 1), 6.70 (d, 1), 6.50 (d, 1), 6.16 (br, 2), 4.50 (t, 2), 4.10 (s, 2), 3.52 (m, 4), 3.05 (t, 2), 2.76 (m, 2), 2.68 (m, 2), 2.62 (s, 6), 2.42 (s, 3), 2.10 (m, 2) ppm. WO 01/14371 PCMJS00/23173 To 2-[(3-aminopropyl)[2-(1 H-imida2ol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide (0.3 g, 0.7 mmol) (a compound of formula (Yc6)) dissolved in pyridine (5 mL) was added acetic anhydride (0.10 mL, 1.0 mmol). After stirring for 16 hours, the reaction was partitioned with ethyl acetate and water. The organic layer was separated, washed 5 with water and brine, dried (NazS04), and the solvent was removed in vacuo. Chromatography on silica with CH2CI2 gave 0.14 g of 2-[[3-(acetylamino)propyl][2-(1H-imidazol-1-yl)-6- methylpyrimidin-4-yl]amino]-A/-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Yc7); NMR (DMSO-d6) 8.4 (s, 1), 8.05 (t, 2), 7.85 (t, 1), 7.8 (s, 1), 7.05 (s, 1), 6.7 (m, 2), 6.6 (m, 1), 6.2 (s, 1), 5.9 (s, 2), 4.1 (m, 2), 3-3.6 (m, 6), 2.6 (m, 2), 2.3 (m, 3), 1.8 (s, 3), 1.65 (m. 2) ppm. 10 The following compounds of formula (Yc7) and derivatives thereof were prepared in a similar manner with appropriately substituted starting materials: 2-[[3'-(methylsulfonylamino)propyl][2-(l H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide; NMR (CDCI3) 8.45 (s, 1), 7.65 (s, 1), 7.0 (s, 1), 6.55 (m, 2), 6.5 (s, 1), 6.45 (d, 1), 6.15 (br, 1), 5.95 (br, 1), 5.85 (s, 2), 4.1 (s, 2), 3.65 (br, 2), 15 3.45 (m, 2), 3.2 (dd,2), 2.9 (s, 3), 2.65 (t, 2), 2.35 (s, 3). 1.9 (m, 2) ppm; 2-[[3-(methoxycarbonylamino)propyl][2-(1H-imidazol-1-yl)-6'methylpyrimidin-4-yl]amino]-N-[2- (1,3-benzodioxol-5-yl)ethyl]acetamide; NMR (CDCI3) 8:45 (s, 1), 7.7 (s, 1), 7.1 (s, 1), 6.55 (d, 1), 6.5 (s, 1), 6.45 (d, 1), 6.3 (br, 1), 6,1 (br, 1), 5,9 (s, 2), 4.1 (s, 2), 3.7 (s, 3), 3.5 (m, 2), 3.2 (dd, 2), 2.7 (t, 2), 2.4 (s. 3), 1.85 (m, 4) ppm; 20 2-[[3-(methylsulfonylamino)propyl][2-(1H-imidazol-1-yl)-6-rnethylpyrimidin-4-yl]amino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; NMR (CDCl3) 8.45 (s, 1), 7.75 (s, 1), 7.1 (s, 1), 6.95 (d, 2), 6.7 (d, 2), 6.25 (br, 1), 6.15 (br, 1), 4.1 (s, 2), 3.75 (s, 3), 3.6 (br, 2), 3.5 (m, 2), 3.2 (dd, 2), 2.95 (s, 3), 2.7 (t, 2), 2.4 (s, 3), 1.85 (m, 2) ppm; 2-[[3-(methoxycarbonylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-{4- 25 methoxypheny!)ethyl]acetamide; NMR (CDCI3) 8.45 (s,'l), 7.75 (s, 1), 7.1 (s, 1), 6.9 (d, 2), 6.7 (d, 2), 6.2 (br, 1), 6.1 (br, 1), 4.05 (s, 2), 3.75 (s, 3), 3.65 (s, 2), 3.5 (s, 3), 3.2 (m, 2), 2.7 (t, 2), 2.4 (s, 3), 1.8 (m, 4) ppm; 2-[[3-(acetylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N[2-(4- methoxyphenyl)ethyl]acetamide; NMR (CDCI3) 8.45 (s, 1), 7.7 (s, 1), 7.05 (s, 1), 6.9 (d, 30 2), 6.65 (d, 2), 6.4 (br, 1), 6.1 (s, 1), 4.05 (s, 2), 3.7 (s, 3), 3.5 (m, 4), 3.25 (dd, 2), 2.7 (t, 2), 2.4 (s, 3), 1.9 (s, 3), 1.8 (m, 2) ppm; 2-[[3-(methoxycarbonylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimid|n-4-yl]amino]-N-[2- (1,4-benzodioxan-6-yl)ethyl]acetamide; NMR (CDCI3) 8.60 (s, 1), 7.78 (s, 1), 7.08 (s, 1), 6.64 ( d, 1), 6.45 (s, 1), 6.44 (d, 1), 6.25 (br, 1), 6.15 (s, 1), 5.05 (br, 1),4.12 ( m, 6), 3.65 35 (s, 3), 3.45 (m, 4), 3.20 (m, 2), 2.65 (t, 2), 2.40 (s, 3), 1.80 (m, 2} ppm; 2-[[3-(acetylamino)propyl](2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,4- benzodioxan-6-yl)ethy!]acetamide; NMR (CDCI3) 8.50 (s, 1), 7.75 (s, 1), 7.06 ( s, 1), 6.62 WO 01/14371 PCT/USOO/23173 ( d. 1). 6.58 (br, 1), 6.45 (s, 1), 6.42 (d, 1), 6.15 (s, 1), 4.10 ( m, 6), 3.55 (m, 4), 3.30 (m, 2), 2.64 (t, 2), 2.40 (s, 3), 1.92 (s, 3), 1.82 (m, 2) ppm; 2-[[3-(methylsulfonylamino)propyl][2-(1H-irnidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,4- benzodioxan-6-yl)etnyl]acetamide; NMR (CDCI3) 8.46 (s, 1), 7.76 (s, 1), 7.03 (s, 1), 6.65 5 (d, 1), 6.50 (s,1), 6.42 (d, 1), 6.18 (br, 1), 5.80 (br, 1), 4.20 (m, 6), 3.65 (br, 2), 3.48 (m, 2), 3.20 (m, 2), 2.92 (s, 3), 2.65 (m, 2), 2.40 (s, 3), 1.90 (m, 2) ppm; 2-[[3-(acetylamino)propyl](2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; NMR (CDCI3) 8.46 (s, 1), 7.76 (s, 1), 7.05 (s, 1), 6.86 (s, 1), 6.72 (d, 1), 6.55 (d, 1), 6.45 (br, 2), 6.13 (s, 1), 4.50 (t, 2), 4.08 (s, 2), 3.55 (m, 10 4), 3.30 (q, 2), 3.06 (t, 2), 2.66 (t, 2), 2.40 (s, 3), 1.93 (s, 3), 1.85 (m, 2) ppm; 2-[[3-(methoxycarbonylamino)propyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]-N-[2- (2,3-dihydrobenzofuran-5-yl)ethyl]acetamide; NMR (CDCI3) 8.46 (s, 1), 7.76 (s, 1), 7.05 (s, 1), 6.84 (s, 1), 6.70 (d, 1), 6.54 (d, 1), 6.26 (br, 2), 6.10 (s, 1), 5.08 (br, 1),4.50 (t, 2), 4.06 (s, 2), 3.65 (s, 3), 3.50 (m, 4), 3.22 (q, 2), 3.04 (t, 2), 2.66 (t, 2), 2.42 (s, 3), 1.80 (m, 15 2) ppm; and 2-[[3-(methylsulfonylamino)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; NMR (CDCI3) 8.44 (s, 1), 7.74 (s, 1), 7.02 (s. 1), 6,86 (s, 1), 6.72 (d, 1), 6.52 (m, 2), 6.19 (S, 2), 5.80 (br, 1), 4.50 (t, 2), 4.10 (s, 2), 3.62 (br, 2), 3.46 (q, 2), 3.20 (q, 2), 3.06 (t, 2), 2.95 (s, 3), 2.66 (t, 2), 2.38 (s, 3), 1.86 (m, 2) 20 ppm. To2-[(3-aminopropyl)[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4-methoxyphenyl)ethyl]acetamide (135 mg, 0.32 mmol) (a compound of formula (Yc6)) in pyridine (1.5mL) was added water (1.5 mL) solution of potassium cyanate (64 mg, 0.76 mmol). The mixture was stirred and heated in an oil bath at 80°C overnight. The mixture was poured into 25 water and extracted with ethyl acetate (3x20mL). The combined ethyl acetate fractions were washed with brine, dried over sodium sulfate and concentrated. The residue was purified by chromatography on silica gel (9:1 CH3CN/NH4OH) to afford 2-[[3-(ureido)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(4-methoxyphenyl)ethyl]acetamide, a compound of formula (Yc9); as a white solid; NMR (DMSO-d6, 90 C) 8.4 (s, 1), 7.8 (s, 1), 7.05 (d, 2), 7.0 (s, 1), 30 6.75 (d, 2), 6.4 (s, 1), 4.1 (s, 2), 3.7 (s, 3), 3.5 (m, 2). 3.25 (m, 2), 3.05 (m, 2), 2.65 (t, 2), 2.3 (s, 3), 1.7 (m, 2) ppm. The following compounds of formula (Yc9) and derivatives thereof were prepared in a similar manner with the appropriately substituted starting materials: 2-[[3'(ureido)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(1,4-benzodioxan-6- 35 yl)ethyl]acetamide; NMR (DMSO-d6) 8.42 (br, 1), 8.08 (t, 1), 7.80 (br, 1), 7.05 (s, 1), 6.60 ( m, 3), 6.03 (br, 1), 5.45 (br, 1), 4.18 (br, 6),. 3.40 (m, 6), 3.00 (m, 2), 2.55 (m, 2), 2.35 (br, 3), 1.70 (m, 2) ppm; and WO 01/14371 PCT/USOO/23173 2-[[3-(ureido)propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-N[2-(2,3- dihydrobenzofuran-5-yl)ethyl]acetamide; NMR (DMSO-d6) 8.45 (br, 1), 8.12 (br, 1), 7.80 (br, 1), 7.00 (m, 2), 6.82 (m, 1), 6.60 (br, 1), 6.10 (br, 1), 5.42 (br, 1), 4.42 (t, 2), 4.14 (m, 2), 3.00-3.60 (m, 10), 2.60 (m, 2), 2.30 (s, 3), 1.68 (m, 2) ppm. Reaction Scheme 4 depicts another method of preparing compounds of formula (Yc). Compounds of formula (Ya) and formula (Yb) may be similarly prepared. Reaction Scheme 4 Compounds of formulae (YdO) are prepared by methods disclosed herein. Each R1, R2, m and n are independently as described above in the Summary of the Invention for compounds of formula (Ya), formula (Yb) and formula (Yc); and R5 and W are also as described above in the Summary of the Invention for compounds of formula (Ya), formula (Yb) and formula (Yc). The above synthesis may be carried out as follows: To 2-[[3-[(1,3-benzodioxol-5-ylmethyl)amino](methy!)propyl][2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]acetic acid, ethyl ester (2.2 g, 4.6 mmol) (a compound of formula (YdO)) dissolved in THF (50 mL) was added LiOH (0.34 g, 8.1 mmol) and water (10 mL). After stirring for 16 hours, the solvent was removed in vacuo and 1 N HCI (8.1 mL, 8.1 mmol) was added. The solvent was removed in vacuo to give 2-[[3-[(l,3-benzodioxol-5- WO 01/14371 PCT/US00/23173 ylmethyl)(methyl)amino]propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]acetic acid, a compound of formula (Yd 1). To2-[[3-[(1,3-benzodioxol-5-ylmethyl)(methyl)amino]propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]acetic acid (0.35 g, 0.8 mmol) (a compound of formula (Yc11)) 5 slurried in DMF (5 mL) was added carbonyldiimidazole (0.14 g, 0.8 mmol). After stirring for 20 minutes, diethylamine (0.25 mL, 2.4 mmol) was added. After stirring for 18 hours, the reaction was partitioned with ethyl acetate and water. The organic layer was separated, washed with water, dried (Na2SO4, and the solvent was removed in vacuo to give 0.91 g of the desired product. Chromatography on silica with CH2CI2/MeOH gave 2-[[3-[[(1,3-benzodioxol-5-10 yl)methyl](methyl)amino]propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]-W,N,N- diethylacetamide; NMR (CDCI3) 8.4 (s, 1), 7:85 (s, 1), 7.1 (m, 1), 6.85 (s, 1), 6.75 (m, 2), 6.4 (br, 1), 5.95 (s, 2), 4.4 (br, 2), 3.6 (br, 2), 3.4 (m, 6), 2.45 (t, 2), 2.35 (s, 3), 2.2 (s, 3), 1.9 (m, 2), 1.3 (t, 3), 1.15 (t, 3)ppm. ' The following compounds of formula (Yc12) and derivatives thereof were prepared in a 15 similar manner: 2-[[3-[[(1,3-benzodioxol-5-yl)methyl](methyl)amino]propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin- . 4-yl]amjno]-N-(2-dimethylaminoethyl)acetamide; NMR (CDCI3) 8.5 (s, 1), 7.8 (s, 1), 7.1 (s, 1), 6.8 (s, 1), 6.75 (m, 2), 6.25 (br, 1), 5.95 (s, 2), 4.15 (br, 2), 3.6 (br, 2), 3.4 (s, 2), 3.35 (m. 2), 2.4 (t, 2), 2.4 (s, 3), 2.35 (t, 2), 2.2 (s, 3), 2.0 (br, 6), 1.8 (m, 2), 1.6 (m, 2) 20 ppm; and 2-[[3-[[(1,3-benzodioxol-5-yl)methyl](methyl)amino]propyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]amino]acetamide; NMR (DMSO-d6) 8.4 (s, 1), 7.8 (s, 1), 7.5 (s, 1), 7.1 (m, 2), 6.8 (m, 3), 6.3 (br, 1), 6.0 (s, 2), 5.4 (br, 1), 4.1 (m, 2), 3.4 (m, 4), 2.4 (t, 2), 2.3 (s, 3), 2.1 (s, 3), 1.75 (m, 2) ppm. ******** While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope 30 of the invention. In addition, many modifications may be made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective, spirit and scope of the present invention. All such modifications are intended to be within the scope of the claims appended hereto. 35 We claim: 1. A N-heterocyclic compound of formula (Ya), formula (Yb) or formula (Yc): wherein: n and m are independently an integer from 1 to 4; A is -C(0)OR1 or -C(0)N(R1)R2; each W is N or CH; each R1 is independently hydrogen, alkyl, aryl or aralkyl; each R2 is independently hydrogen, C1-C20 alkyl, -(CH2)n-N(R1)2 heterocyclylalkyl (optionally substituted by alkyl, halo, haloalkyl or alkoxy), aralkyl (optionally substituted by halo, alkyl, alkoxy, or-N(R1)2); when m is an integer from 2 to 4, R4can be hydroxyl, -N(R')R2, -N(R1)-C(O)-R1, -N(R1)-C(O)OR1, -N(R1)-S(O)1-R1or-N(R1)-C(O)N(R1)2: when m is an integer from 1 to 4, R4 can also be cyano or heterocyclyl; R5 is hydrogen, halo, alkyl, aryl, aralkyl, or haloalkyl; as a single stereoisomer or mixture thereto, or a pharmaceutically acceptable salt thereof. 2. The N-heterocyclic compound as claimed in claim 1 having the formula (Yc) wherein: nis 1; m is 2 or 3; A is -C(0)OR1 or -O(ON(R1)R2; Each W is CH; R1 is hydrogen or alkyl; and R2 is hydrogen, alkyl, -(CH)a-N(R1)2, optionally substituted heterocyclylalkyl or optionally substituted aralkyl. 3. The N-heterocyclic compound as claimed in claim 2 wherein R4 is -N(R1)R2 where R1 is hydrogen or alkyl and R2 is heterocyclylalkyl selected from the group consisting of (1, 3-benzodioxol-5-yl)methyl or (l,4-benzodioxan-6-yl)methyl. 4. The N-heterocyclic compound as claimed in claim 3 selected from the group consisting of: 2-[[3-[[(1,3-benzodioxol-5-yl)methyl](methyl)amino]propyl][2-{1H-irnidazol-1-yl)-6-methylpyrirrtidin- 4-yl]amino]acetic acid, ethyl ester; 2-[[3-[[(1,3-benzodioxol-5-yl)methyl]{methyl)amirio]propyl][2-{1H-irriidazol-1-yl)-6-methy!pyrirnidin- 4-yi]amino]-N,yv-diethylacetamide; 2-[[3-[[(1,3-benzodioxol-5-yl)methyl](methyl)amino]propyl][2-{1/y-imidazol-1-yl)-6-metriylpyrirnidin- 4-yl]amino]-/V-{2-diinethylaminoetriyl}acetamide; 2-[[3-[[(1,3-benzodioxol-5-yl)methyl](methyl)arnino]propy[3[2-(1H-imidazol-1-yl)-6-methylpyrimidin- 4-yl]arnino]acetamide; 2-{[3-[(1,3-benzodioxoi-5-yl)methyl]aminopropyl][2-{1W-im(da20i-1-y^6-methy!pyrimidin-4- yl]amino]-N,N-diethylacetamide; 2-[[3-[(1>benzodioxd-5-yl)methynaminopropylK2-(1H-imidazol-1.-yl)-6-rnethy!pyrimidtn-4- yl]amino]-N-methylacetamide; 2-[{3-{(1,4-benzodioxan-6-yl)metriylJaminopropyl][2-(1W-imidazol-1-yO-6-memylpyrimidin-4- yi]amino]-N-methylacetamide; 2-[[3-[(1,4-benzodioxan-6-yl)rnelhyl]aminopropyl][2--(1H-imida2ol-1-yl}-6-methylpyrimidin-4- y!]amino]-N,N-diethylacetamJde; 2-p-[( 1,4-benzodioxan-6-yl)metriy)]aminopropyf][2-(1H-imidazol-1 -yl)-6-methylpyrimidin-4-yl]amino]acetamide; and 2-([3-[(1l3-benzodioxol-5-yl)methyl3aminopropyl][2-(1H-imidazol-1-yl)-6-methylpyrimidin-4- yljaminojacetamide. 5. The N-heterocyclic compound as claimed in claim 2 wherein R4 is heterocyclyl. 6. The N-heterocyclic compound as claimed in claim 5 selected from the group consisting of: 2-[[pyridin-3-ylmethyl][241H-imidazol-1-yl)-6-methylpyrimidin-4-yl]arninoJ-N-[2-(T,3-benzodioxol- 5-yl)ethyl]acetamide; 2-[[2-(1 H-imidazol-1 -yl)-6-methylpyrimidin-4-yl][(1,3-benzodioxol-5-yl)methyl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethyl]acetamide; and 2-f[2-( 1H-imidazol-1 -yl)-6-methylpyrimidin-4-yl][2-(morpholin-4-yl)ethyl]amino]-N-[2-( 1,3- benzodioxol-5-yl)ethyl]acetamide. 7. The N-heterocyclic compound as claimed in claim 2 wherein R4 is or -or hydroxy, cyano, -N(R')R2, -N(R1)-C(O)-R1, -N(R1)-C(0)OR1, -N(R1)-S(O)1R1, N(R')-C(0)-N(R')2, where each R1 and each R2 is independently hydrogen, alkyl aralkyl. 8. The N-heterocyclic compound as claimed in claim 7 selected from the group consisting of: 2-n3-hydroxyprdpyl]{2-(1 H-imidazol-1 -yt)^rne«iylpyrtn=Hdir)-4-yflaniioo3-M.(241 ^benzodioxDl-S- yl)ethyl]acetamide; 2-[[2-cyanoethyl][2-(1 H-irnidazol-1 -yl)-6-methy!pyrimidin-4-yl]amino]-Af-t2-( 1,3-benzodk>xol-5- yl)ethyl)acetamide; 24[34dime%lamino}propyO[241H-im/dazol-1-yl>6-methytpyrimidin-4-y(Jamino]-/V-{2-(1,3- benzodioxol-5-yl)ethyi]acetamide; 2-^3- benzadioxol-5-yl)ethylJacetamide; 2-n3-(methylsulfonylamino)propyl][2-(1H"imidazol-1-yl)-6-methylpyrirnidin-4-yl]amtno]-W-[2-(1,3- benzodioxoi-5-yl}ethyl]acetamide; 2-[{3-(methoxycarbonylarriino)prQpyl][2-{1H-irnidazol-1-yl)-6-rnethylpyrimidin-4-yl]arnino]-W-[2- (1,3-benzodioxol-5-yi)ethyl]acetamide; 2-p-(phenylmethylamino)propyl]f241W-imidazol-1-yl>-6-rrieihylpyrimidin-4-yl]amino]-N-[2-(1,3- benzodioxol-5-yl)ethy!]acetamide; 2-[[3-aminopropyl][2-(1 H-imidazd-1-yt)-6-methylpyrimidin-4-yl]amino3-/V-[2-{ 1,3-benzodioxol-5- yl)etrtyl]acetamide; 2-[I3-aminopropyl][2-(1H-imidazol-1-yt)-6-methyipyrimidin-4-yl]amino]-W-[2-(4- methoxyphenyl)ethyi]acetamide; 2-[p-{me%lsu!fonylamino)propyl][2-(1H-imidazol'1-yl)-6-rnethylpyrimidin-4-yl]arnino]-N-[2-(4- methoxyphenyl)ethyl]acetamide; 2-[[3-(ureido)propyl][2-lH-imidazol-l-yl)-6-methylpyrimidin-4-yl]amino]-N-[2-(253-Dihydrobenzofuran-5-yl)ethyl]acetamide. 9. A pharmaceutical composition comprising a compound of formula (Ya), formula (Yb) or formula (Yc) as claimed in claim 1: wherein: n and m are independently an integer from 1 to 4; A is -C(0)OR! or -C(O)N(R1)R2; each W is N or CH; each R1 is independently hydrogen, alkyl, aryl or aralkyl; each R2 is independently hydrogen, C1-C2o alkyl, -(CH2)n-N(R1)2, heterocyclylalkyl (optionally substituted by alkyl, halo, haloaikyl or alkoxy), aralkyl (optionally substituted by halo, alkyl, aikoxy, or-N(R1)2); when m is an integer from 2 to 4, R4 can be hydroxy, -N(R1)R2, -N(R1)-C(O)-R1, -N(R)-C(0)OR1 -N(R1)-S(0),-R1, or-N(R1)-C(0)-N(R,)2; when m is an integer from 1 to 4, R4 can also be cyano or heterocyclyl; Rs is hydrogen, halo, alkyl, aryl, aralkyl, or haloaikyl; as a single stereoisomer or mixture thereto, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient thereof of the kind such as herein described. Dated this 25th day of February, 2002 [RANJNA MEHTA-DUTT] OF REMFRY AND SAGAR ATTORNEY FOR THE APPLICANTS

Documents:

in-pct-2002-00232-mum-abstract(26-7-2007).doc

in-pct-2002-00232-mum-abstract(26-7-2007).pdf

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