|Title of Invention
NOVEL COMPOUNDS OF GENERAL FORMULA I AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS
|The invention provides novel compounds of the formula I below: (I), wherein the meaning of each substituent is defined in the application. The compounds are useful as inhibitors of the glycine transporter and useful in the treatment of diseases responsive to the inhibition of the glycine transporter. The invention provides a pharmaceutical composition comprising a compound of Formula I as defined above and the use of compounds as above for the manufacture of medicaments for treatment of diseases responsive to ligands of the glycine transporter.
11. The compound according to claim 10 wherein the disease is responsive to
antagonism of the glycine transporter.
12. The compound according to claims 10 and 11, wherein the disease is selected from the group is consisting of the positive and the negative symptoms of schizophrenia, psychoses, dementia, pain, improving cognition, Alzheimer's disease, multi-infarct dementia, AIDS dementia, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis or diseases wherein the brain is damaged by inner or outer influence, such as trauma to the head or stroke.
13. A pharmaceutical composition substantially as herein described and exemplified.