| Abstract |
A pharmaceutical composition comprising a suitable pharmaceutical carrier and further comprising biodegradable and biocompatible mircroparticles containing a 1,2-benzazole of formula I (diagram) R is hydrogen or C 1-6 alky, R1 and R2 independently are hydrogen, halo, hydroxy, C106 alkyloxy and C1-6 alkyl; X is O or S; Alk is C104 alkanediyl; and R3 is hydrogen or C1-6 alkyl; Z is - S-, CH2 , or CR4 =CR5- where R4 and R5 independently are hydrogen or C106 alkyl; A is a bivalent radical- CH2-CH2, CH2-CH2 CH2 0r CR6 = CR7, wherein R6 and R7 are hydrogen, halo, amino or C1-6 alkyl; and R8 is hydrogen or hydroxyl, or a pharmaceutically acceptable acid addition salt thereof, said microparticles being made of a polymeric matrix material having a molecular weight in the range of 100.000 to 300.000 Daltons, and being capable of releasing said 1, 2-benzazole or salt thereof over an extended period of time. |