Title of Invention	PROCESS FOR PREPARATION OF ARIPIPRAZOLE CRYSTALLINE POLYMORPHS
Abstract	The present invention provides a process for preparation of aripiprazole crystalline polymorph. The present invention also provides processes for preparation of aripiprazole hydrochloride crystalline polymorphs. Thus, for example aripiprazole is dissolved in tetrahydrofuran and the solvent is removed by spray drying at 2Soc to give aripiprazole crystalline form II.

Full Text

The present invention provides novel crystalline forms of aripiprazole and aripiprazole hydrochloride, processes for their preparation and pharmaceutical compositions containing them. BACKGROUND OF THE INVENTION Aripiprazole of formula (1): or 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)- quinolinone and its salts are useful for treating schizophrenia and their therapeutic uses were disclosed in US 5,006,528. Processes for the preparation of aripiprazole and its salts were described in US 5,006,528. These processes do not produce well defined, reproducible crystalline forms. Thus there is a need for stable and reproducible crystalline forms of aripiprazole and its salts. We have discovered two novel crystalline forms of aripiprazole and four novel crystalline forms of aripiprazole hydrochloride. The novel forms have been found to be stable over the time and reproducible and so, suitable for pharmaceutical preparations. Thus, the object of the present invention is to provide stable novel crystalline forms of aripiprazole, processes for preparation of the novel crystalline forms and pharmaceutical compositions containing these novel crystalline forms. Another object of the present invention is to provide stable novel crystalline forms of aripiprazole hydrochloride, processes for preparation of the novel crystalline forms and pharmaceutical compositions containing these novel crystalline forms. Since the novel crystalline forms of aripiprazole hydrochloride are obtained with high purity, preparation of aripiprazole via the crystalline forms of aripiprazole hydrochloride serves as a means of producing pure aripiprazole. SUMMARY OF THE INVENTION According to one aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form I, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 8.7, 11.6, 16.3, 17.7, 18.6, 20.3, 23.4, 24.9 degrees. Figure 1 shows typical Form I x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form I of aripiprazole comprising the steps of: a) dissolving aripiprazole in a suitable solvent; b) refluxing for about 30 minutes to 1 hour; c) cooling slowly to about 15°C to 25°C; d) maintaining for about 2 hour to 4 hours at about 15°C to 25°C; and e) filtering the solid separated. The suitable solvent is selected from the group consisting of acetone, ethyl acetate, methanol or ethanol. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form II, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 12.7, 15.1, 17.5, 18.2, 18.8, 19.5, 20.6, 21.2, 22.6, 23.3, 24.2, 24.9, 27.6, 30.0, 31.6, 35.8 degrees. Figure 2 shows typical Form II x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form II of aripiprazole, which comprises dissolving aripiprazole in tetrahydrofuran and vacuum drying at about 25°C or spray drying. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form A, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 6.2, 8.5, 11.5, 15.2, 15.5, 16.8, 17.2, 18.3, 18.9, 19.6, 20.6, 21.3, 23.4, 24.1, 24.7, 25.9, 27,5, 28.3, 28.9, 32.8 degrees. Figure 3 shows typical Form A x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form A of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in methanol or isopropyl alcohol; b) adding hydrochloric acid; c) maintaining for about 1 hour to 3 hours at about 15°C to 25°C; d) filtering the solid separated. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form B, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 9.3, 14.8, 16.4, 17.4, 18.7, 19.7, 21.4, 21.9, 23.8, 25.1, 25.9, 29.7 degrees. Figure 4 shows typical Form B x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form B of aripiprazole hydrochloride comprising the steps of; a) dissolving aripiprazole in a ketonic solvent; b) adding hydrochloric acid; c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; d) filtering the solid separated. The ketonic solvent is selected from the group consisting of acetone, methyl isobutyl ketone and methyl ethyl ketone. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form C, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 3.3, 10.3, 14.2, 14.6, 15.1, 16.4, 16.6, 19.4, 20.3, 20.8, 24.5, 24.9, 25.5, 26.4, 26.7, 28.5, 29.3, 30.1 degrees. Figure 5 shows typical Form C x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form C of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in an ester solvent; b) adding hydrochloric acid; c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; d) filtering the separated solid. The ester solvent is selected from the group consisting of ethyl acetate, methyl acetate, ethyl formate and tert-butyl acetate. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form D, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.0, 14.7, 16.4, 17.4, 19.0, 19.3, 19.8, 21.4, 23.4, 24.7, 25.4 degrees. Figure 6 shows typical Form D x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form D of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in tetrahydrofuran; b) adding hydrochloric acid; c) maintaining for about 2 hour to 4 hours at about 15°C to 25°C; d) filtering the solid separated. According to another aspect of the present invention there is provided a pharmaceutical composition comprising crystalline Form I or Form II of aripiprazole. According to another aspect of the present invention there is provided a pharmaceutical composition comprising novel crystalline form of aripiprazole hydrochloride. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a x-ray powder diffraction pattern of crystalline Form I of aripiprazole. Figure 2 is a x-ray powder diffraction pattern of crystalline Form II of aripiprazole. Figure 3 is a x-ray powder diffraction pattern of crystalline Form A of aripiprazole hydrochloride. Figure 4 is a x-ray powder diffraction pattern of crystalline Form B of aripiprazole hydrochloride. Figure 5 is a x-ray powder diffraction pattern of crystalline Form C of aripiprazole hydrochloride. Figure 6 is a x-ray powder diffraction pattern of crystalline Form D of aripiprazole hydrochloride. x-Ray powder diffraction spectrum was measured on a Siemens diffractometer. DETAILED DESCRIPTION OF THE INVENTION According to one aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form I, characterized by an x-ray powder diffraction pattern having peaks expressed as 28 at about 8.7, 11.6, 16.3, 17.7, 18.6, 20.3, 23.4, 24.9 degrees. Figure 1 shows typical Form I x-ray powder diffraction pattern. According to another aspect of the present invention, there is provided a process for preparation of the Form I of aripiprazole. Thus aripiprazole is dissolved in a suitable solvent. The suitable solvent is selected from the group consisting of acetone, ethyl acetate, methanol and ethanol. Aripiprazole obtained by a known method or crystalline Form II of aripiprazole obtained by the process described below may be used. The solution is refluxed for about 30 minutes to 1 hour. The solution is then cooled slowly to about 15°C to 25°C in about 1 hour and maintained for about 2 hour to 4 hours at the same temperature. The separated crystals are filtered and dried to give Form I of aripiprazole. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form II, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 12.7, 15.1, 17.5, 18.2, 18.8, 19.5, 20.6, 21.2, 22.6, 23.3, 24.2, 24.9, 27.6, 30.0, 31.6, 35.8 degrees. Figure 2 shows typical Form II x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form II of aripiprazole, which comprises dissolving aripiprazole in tetrahydrofuran and vacuum drying at about 25°C or spray drying. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form A, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 6.2, 8.5, 11.5, 15.2, 15.5, 16.8, 17.2, 18.3, 18.9, 19.6, 20.6, 21.3, 23.4, 24.1, 24.7, 25.9, 27,5, 28.3, 28.9, 32.8 degrees. Figure 3 shows typical Form A x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form A of aripiprazole hydrochloride. Thus aripiprazole is dissolved in ethahol or isopropyl alcohol. If necessary, the solvent may be heated to effect dissolution of aripiprazole. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 3 hours at about 15°C to 25°C and the separated crystals are filtered and dried to yield Form A of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form B, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.3, 14.8, 16.4, 17.4, 18.7, 19.7, 21.4, 21.9, 23.8, 25.1, 25.9, 29.7 degrees. Figure 4 shows typical Form B x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form B of aripiprazole hydrochloride. Thus aripiprazole is dissolved in a ketonic solvent. If necessary, the solvent may be heated to dissolve aripiprazole. The ketonic solvent is acetone or methyl isobutyl ketone or methyl ethyl ketone; or mixture thereof. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 4 hours at about 15°C to 25°C and the separated crystals are filtered and dried to yield Form B of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form C, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 3.3, 10.3, 14.2, 14.6, 15.1, 16.4, 16.6, 19.4, 20.3, 20.8, 24.5, 24.9, 25.5, 26.4, 26.7, 28.5, 29.3, 30.1 degrees. Figure 5 shows typical Form C x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form C of aripiprazole hydrochloride. Thus aripiprazole is dissolved in an ester solvent. If necessary, the solvent may be heated to effect dissolution of aripiprazole. The ester solvent is selected from the group consisting of ethyl acetate, methyl acetate, ethyl formate and tert-butyl acetate. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 4 hours at about 15°C to 25°C and the separated solid is filtered and dried to obtain Form C of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form D, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.0, 14.7, 16.4, 17.4, 19.0, 19.3, 19.8, 21.4, 23.4, 24.7, 25.4 degrees. Figure 6 shows typical Form D x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form D of aripiprazole hydrochloride. Thus aripiprazole is dissolved in tetrahydrofuran. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for 2 hour to 4 hours at about 15°C to 25°C and the separated crystals are filtered and dried to produce Form D of aripiprazole hydrochloride. The novel crystalline forms of aripiprazole hydrochloride obtained by the processes described above are very pure. So, aripiprazole with high purity can be obtained by basifying a solution of aripiprazole hydrochloride crystalline form and isolating aripiprazole from the solution by usual processes known in the art. According to another aspect of the present invention there is provided a pharmaceutical composition comprising Form I or Form II of aripiprazole and a pharmaceutical^ acceptable carrier. According to another aspect of the present invention there is provided a pharmaceutical composition comprising crystalline form of aripiprazole hydrochloride and a pharmaceutical^ acceptable carrier. The crystalline form may be Form A, Form B, Form C or Form D. The forms of aripiprazole or aripiprazole hydrochloride may be formulated in a form suitable for oral administration or injection. The examples of pharmaceutical compositions are tablets, capsules, powders, suspensions, emulsions, injections and the like. The following examples will serve to further illustrate the invention. Example 1 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in acetone (42 ml) and refluxed for 30 minutes. The solution is slowly cooled to 25°C in 1 hour and maintained at 25°C for 3 hours. The separated crystals are filtered and dried to give 1 gm of Form I of aripiprazole. Example 2 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran and the solvent is removed by vacuum drying at 25°C for 6 hours to give Form II of aripiprazole in quantitative yield. Example 3 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran and the solvent is removed by spray drying at 25°C for 6 hours to give Form II of aripiprazole in quantitative yield. Example 4 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in methanol (12 ml) and cone, hydrochloric acid (1 ml) is added to the solution. The contents are maintained for 2 hours at 25°C and the separated solid is filtered to give 2 gm of Form A of aripiprazole hydrochloride. Example 5 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in acetone (12 ml) and cone, hydrochloric acid (1ml) is added to the solution. The contents are maintained for 3 hours at 25°C and the separated solid is filtered to give 1.9 gm of Form B of aripiprazole hydrochloride. Example 6 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in ethyl acetate (12 ml). 10% WA/ HCI in ethyl acetate (4 ml) is added to the solution. The solution is maintained at 25°C for 2 hours and the separated crystals are collected by filtration to give 2 gm of Form C of * aripiprazole hydrochloride. Example 7 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran (12 ml) and cone, hydrochloric acid (1ml) is added to the solution. The contents are maintained for 3 hours at 25°C and the separated solid is collected by filtration to give 2 gm of Form D of aripiprazole hydrochloride. Example 8 Example 1 is repeated using Form II of aripiprazole instead of aripiprazole to give Form I of aripiprazole. Example 9 Example 2 is repeated using Form I of aripiprazole instead of aripiprazole to give Form II of aripiprazole. Example 10 Example 5 is repeated using Form I of aripiprazole instead of aripiprazole to give Form B of aripiprazole hydrochloride. Example 11 Example 7 is repeated using Form II of aripiprazole instead of aripiprazole to give Form D of aripiprazole hydrochloride. The present invention provides novel crystalline forms of aripiprazole and aripiprazole hydrochloride, processes for their preparation and pharmaceutical compositions containing them. BACKGROUND OF THE INVENTION Aripiprazole of formula (1): or 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)- quinolinone and its salts are useful for treating schizophrenia and their therapeutic uses were disclosed in US 5,006,528. Processes for the preparation of aripiprazole and its salts were described in US 5,006,528. These processes do not produce well defined, reproducible crystalline forms. Thus there is a need for stable and reproducible crystalline forms of aripiprazole and its salts. We have discovered two novel crystalline forms of aripiprazole and four novel crystalline forms of aripiprazole hydrochloride. The novel forms have been found to be stable over the time and reproducible and so, suitable for pharmaceutical preparations. Thus, the object of the present invention is to provide stable novel crystalline forms of aripiprazole, processes for preparation of the novel crystalline forms and pharmaceutical compositions containing these novel crystalline forms. Another object of the present invention is to provide stable novel crystalline forms of aripiprazole hydrochloride, processes for preparation of the novel crystalline forms and pharmaceutical compositions containing these novel crystalline forms. Since the novel crystalline forms of aripiprazole hydrochloride are obtained with high purity, preparation of aripiprazole via the crystalline forms of aripiprazole hydrochloride serves as a means of producing pure aripiprazole. SUMMARY OF THE INVENTION According to one aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form I, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 8.7, 11.6, 16.3, 17.7, 18.6, 20.3, 23.4, 24.9 degrees. Figure 1 shows typical Form I x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form I of aripiprazole comprising the steps of: a) dissolving aripiprazole in a suitable solvent; b) refluxing for about 30 minutes to 1 hour; c) cooling slowly to about 15°C to 25°C; d) maintaining for about 2 hour to 4 hours at about 15°C to 25°C; and e) filtering the solid separated. The suitable solvent is selected from the group consisting of acetone, ethyl acetate, methanol or ethanol. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form II, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 12.7, 15.1, 17.5, 18.2, 18.8, 19.5, 20.6, 21.2, 22.6, 23.3, 24.2, 24.9, 27.6, 30.0, 31.6, 35.8 degrees. Figure 2 shows typical Form II x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form II of aripiprazole, which comprises dissolving aripiprazole in tetrahydrofuran and vacuum drying at about 25°C or spray drying. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form A, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 6.2, 8.5, 11.5, 15.2, 15.5, 16.8, 17.2, 18.3, 18.9, 19.6, 20.6, 21.3, 23.4, 24.1, 24.7, 25.9, 27,5, 28.3, 28.9, 32.8 degrees. Figure 3 shows typical Form A x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form A of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in methanol or isopropyl alcohol; b) adding hydrochloric acid; c) maintaining for about 1 hour to 3 hours at about 15°C to 25°C; d) filtering the solid separated. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form B, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 9.3, 14.8, 16.4, 17.4, 18.7, 19.7, 21.4, 21.9, 23.8, 25.1, 25.9, 29.7 degrees. Figure 4 shows typical Form B x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form B of aripiprazole hydrochloride comprising the steps of; a) dissolving aripiprazole in a ketonic solvent; b) adding hydrochloric acid; c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; d) filtering the solid separated. The ketonic solvent is selected from the group consisting of acetone, methyl isobutyl ketone and methyl ethyl ketone. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form C, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 3.3, 10.3, 14.2, 14.6, 15.1, 16.4, 16.6, 19.4, 20.3, 20.8, 24.5, 24.9, 25.5, 26.4, 26.7, 28.5, 29.3, 30.1 degrees. Figure 5 shows typical Form C x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form C of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in an ester solvent; b) adding hydrochloric acid; c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; d) filtering the separated solid. The ester solvent is selected from the group consisting of ethyl acetate, methyl acetate, ethyl formate and tert-butyl acetate. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form D, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.0, 14.7, 16.4, 17.4, 19.0, 19.3, 19.8, 21.4, 23.4, 24.7, 25.4 degrees. Figure 6 shows typical Form D x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form D of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in tetrahydrofuran; b) adding hydrochloric acid; c) maintaining for about 2 hour to 4 hours at about 15°C to 25°C; d) filtering the solid separated. According to another aspect of the present invention there is provided a pharmaceutical composition comprising crystalline Form I or Form II of aripiprazole. According to another aspect of the present invention there is provided a pharmaceutical composition comprising novel crystalline form of aripiprazole hydrochloride. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a x-ray powder diffraction pattern of crystalline Form I of aripiprazole. Figure 2 is a x-ray powder diffraction pattern of crystalline Form II of aripiprazole. Figure 3 is a x-ray powder diffraction pattern of crystalline Form A of aripiprazole hydrochloride. Figure 4 is a x-ray powder diffraction pattern of crystalline Form B of aripiprazole hydrochloride. Figure 5 is a x-ray powder diffraction pattern of crystalline Form C of aripiprazole hydrochloride. Figure 6 is a x-ray powder diffraction pattern of crystalline Form D of aripiprazole hydrochloride. x-Ray powder diffraction spectrum was measured on a Siemens diffractometer. DETAILED DESCRIPTION OF THE INVENTION According to one aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form I, characterized by an x-ray powder diffraction pattern having peaks expressed as 28 at about 8.7, 11.6, 16.3, 17.7, 18.6, 20.3, 23.4, 24.9 degrees. Figure 1 shows typical Form I x-ray powder diffraction pattern. According to another aspect of the present invention, there is provided a process for preparation of the Form I of aripiprazole. Thus aripiprazole is dissolved in a suitable solvent. The suitable solvent is selected from the group consisting of acetone, ethyl acetate, methanol and ethanol. Aripiprazole obtained by a known method or crystalline Form II of aripiprazole obtained by the process described below may be used. The solution is refluxed for about 30 minutes to 1 hour. The solution is then cooled slowly to about 15°C to 25°C in about 1 hour and maintained for about 2 hour to 4 hours at the same temperature. The separated crystals are filtered and dried to give Form I of aripiprazole. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form II, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 12.7, 15.1, 17.5, 18.2, 18.8, 19.5, 20.6, 21.2, 22.6, 23.3, 24.2, 24.9, 27.6, 30.0, 31.6, 35.8 degrees. Figure 2 shows typical Form II x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form II of aripiprazole, which comprises dissolving aripiprazole in tetrahydrofuran and vacuum drying at about 25°C or spray drying. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form A, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 6.2, 8.5, 11.5, 15.2, 15.5, 16.8, 17.2, 18.3, 18.9, 19.6, 20.6, 21.3, 23.4, 24.1, 24.7, 25.9, 27,5, 28.3, 28.9, 32.8 degrees. Figure 3 shows typical Form A x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form A of aripiprazole hydrochloride. Thus aripiprazole is dissolved in ethahol or isopropyl alcohol. If necessary, the solvent may be heated to effect dissolution of aripiprazole. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 3 hours at about 15°C to 25°C and the separated crystals are filtered and dried to yield Form A of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form B, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.3, 14.8, 16.4, 17.4, 18.7, 19.7, 21.4, 21.9, 23.8, 25.1, 25.9, 29.7 degrees. Figure 4 shows typical Form B x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form B of aripiprazole hydrochloride. Thus aripiprazole is dissolved in a ketonic solvent. If necessary, the solvent may be heated to dissolve aripiprazole. The ketonic solvent is acetone or methyl isobutyl ketone or methyl ethyl ketone; or mixture thereof. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 4 hours at about 15°C to 25°C and the separated crystals are filtered and dried to yield Form B of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form C, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 3.3, 10.3, 14.2, 14.6, 15.1, 16.4, 16.6, 19.4, 20.3, 20.8, 24.5, 24.9, 25.5, 26.4, 26.7, 28.5, 29.3, 30.1 degrees. Figure 5 shows typical Form C x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form C of aripiprazole hydrochloride. Thus aripiprazole is dissolved in an ester solvent. If necessary, the solvent may be heated to effect dissolution of aripiprazole. The ester solvent is selected from the group consisting of ethyl acetate, methyl acetate, ethyl formate and tert-butyl acetate. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 4 hours at about 15°C to 25°C and the separated solid is filtered and dried to obtain Form C of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form D, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.0, 14.7, 16.4, 17.4, 19.0, 19.3, 19.8, 21.4, 23.4, 24.7, 25.4 degrees. Figure 6 shows typical Form D x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form D of aripiprazole hydrochloride. Thus aripiprazole is dissolved in tetrahydrofuran. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for 2 hour to 4 hours at about 15°C to 25°C and the separated crystals are filtered and dried to produce Form D of aripiprazole hydrochloride. The novel crystalline forms of aripiprazole hydrochloride obtained by the processes described above are very pure. So, aripiprazole with high purity can be obtained by basifying a solution of aripiprazole hydrochloride crystalline form and isolating aripiprazole from the solution by usual processes known in the art. According to another aspect of the present invention there is provided a pharmaceutical composition comprising Form I or Form II of aripiprazole and a pharmaceutical^ acceptable carrier. According to another aspect of the present invention there is provided a pharmaceutical composition comprising crystalline form of aripiprazole hydrochloride and a pharmaceutical^ acceptable carrier. The crystalline form may be Form A, Form B, Form C or Form D. The forms of aripiprazole or aripiprazole hydrochloride may be formulated in a form suitable for oral administration or injection. The examples of pharmaceutical compositions are tablets, capsules, powders, suspensions, emulsions, injections and the like. The following examples will serve to further illustrate the invention. Example 1 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in acetone (42 ml) and refluxed for 30 minutes. The solution is slowly cooled to 25°C in 1 hour and maintained at 25°C for 3 hours. The separated crystals are filtered and dried to give 1 gm of Form I of aripiprazole. Example 2 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran and the solvent is removed by vacuum drying at 25°C for 6 hours to give Form II of aripiprazole in quantitative yield. Example 3 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran and the solvent is removed by spray drying at 25°C for 6 hours to give Form II of aripiprazole in quantitative yield. Example 4 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in methanol (12 ml) and cone, hydrochloric acid (1 ml) is added to the solution. The contents are maintained for 2 hours at 25°C and the separated solid is filtered to give 2 gm of Form A of aripiprazole hydrochloride. Example 5 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in acetone (12 ml) and cone, hydrochloric acid (1ml) is added to the solution. The contents are maintained for 3 hours at 25°C and the separated solid is filtered to give 1.9 gm of Form B of aripiprazole hydrochloride. Example 6 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in ethyl acetate (12 ml). 10% WA/ HCI in ethyl acetate (4 ml) is added to the solution. The solution is maintained at 25°C for 2 hours and the separated crystals are collected by filtration to give 2 gm of Form C of * aripiprazole hydrochloride. Example 7 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran (12 ml) and cone, hydrochloric acid (1ml) is added to the solution. The contents are maintained for 3 hours at 25°C and the separated solid is collected by filtration to give 2 gm of Form D of aripiprazole hydrochloride. Example 8 Example 1 is repeated using Form II of aripiprazole instead of aripiprazole to give Form I of aripiprazole. Example 9 Example 2 is repeated using Form I of aripiprazole instead of aripiprazole to give Form II of aripiprazole. Example 10 Example 5 is repeated using Form I of aripiprazole instead of aripiprazole to give Form B of aripiprazole hydrochloride. Example 11 Example 7 is repeated using Form II of aripiprazole instead of aripiprazole to give Form D of aripiprazole hydrochloride. The present invention provides novel crystalline forms of aripiprazole and aripiprazole hydrochloride, processes for their preparation and pharmaceutical compositions containing them. BACKGROUND OF THE INVENTION Aripiprazole of formula (1): or 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)- quinolinone and its salts are useful for treating schizophrenia and their therapeutic uses were disclosed in US 5,006,528. Processes for the preparation of aripiprazole and its salts were described in US 5,006,528. These processes do not produce well defined, reproducible crystalline forms. Thus there is a need for stable and reproducible crystalline forms of aripiprazole and its salts. We have discovered two novel crystalline forms of aripiprazole and four novel crystalline forms of aripiprazole hydrochloride. The novel forms have been found to be stable over the time and reproducible and so, suitable for pharmaceutical preparations. Thus, the object of the present invention is to provide stable novel crystalline forms of aripiprazole, processes for preparation of the novel crystalline forms and pharmaceutical compositions containing these novel crystalline forms. Another object of the present invention is to provide stable novel crystalline forms of aripiprazole hydrochloride, processes for preparation of the novel crystalline forms and pharmaceutical compositions containing these novel crystalline forms. Since the novel crystalline forms of aripiprazole hydrochloride are obtained with high purity, preparation of aripiprazole via the crystalline forms of aripiprazole hydrochloride serves as a means of producing pure aripiprazole. SUMMARY OF THE INVENTION According to one aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form I, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 8.7, 11.6, 16.3, 17.7, 18.6, 20.3, 23.4, 24.9 degrees. Figure 1 shows typical Form I x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form I of aripiprazole comprising the steps of: a) dissolving aripiprazole in a suitable solvent; b) refluxing for about 30 minutes to 1 hour; c) cooling slowly to about 15°C to 25°C; d) maintaining for about 2 hour to 4 hours at about 15°C to 25°C; and e) filtering the solid separated. The suitable solvent is selected from the group consisting of acetone, ethyl acetate, methanol or ethanol. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form II, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 12.7, 15.1, 17.5, 18.2, 18.8, 19.5, 20.6, 21.2, 22.6, 23.3, 24.2, 24.9, 27.6, 30.0, 31.6, 35.8 degrees. Figure 2 shows typical Form II x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form II of aripiprazole, which comprises dissolving aripiprazole in tetrahydrofuran and vacuum drying at about 25°C or spray drying. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form A, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 6.2, 8.5, 11.5, 15.2, 15.5, 16.8, 17.2, 18.3, 18.9, 19.6, 20.6, 21.3, 23.4, 24.1, 24.7, 25.9, 27,5, 28.3, 28.9, 32.8 degrees. Figure 3 shows typical Form A x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form A of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in methanol or isopropyl alcohol; b) adding hydrochloric acid; c) maintaining for about 1 hour to 3 hours at about 15°C to 25°C; d) filtering the solid separated. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form B, characterized by an x-ray powder diffraction pattern having peaks expressed as 26 at about 9.3, 14.8, 16.4, 17.4, 18.7, 19.7, 21.4, 21.9, 23.8, 25.1, 25.9, 29.7 degrees. Figure 4 shows typical Form B x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form B of aripiprazole hydrochloride comprising the steps of; a) dissolving aripiprazole in a ketonic solvent; b) adding hydrochloric acid; c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; d) filtering the solid separated. The ketonic solvent is selected from the group consisting of acetone, methyl isobutyl ketone and methyl ethyl ketone. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form C, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 3.3, 10.3, 14.2, 14.6, 15.1, 16.4, 16.6, 19.4, 20.3, 20.8, 24.5, 24.9, 25.5, 26.4, 26.7, 28.5, 29.3, 30.1 degrees. Figure 5 shows typical Form C x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form C of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in an ester solvent; b) adding hydrochloric acid; c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; d) filtering the separated solid. The ester solvent is selected from the group consisting of ethyl acetate, methyl acetate, ethyl formate and tert-butyl acetate. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form D, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.0, 14.7, 16.4, 17.4, 19.0, 19.3, 19.8, 21.4, 23.4, 24.7, 25.4 degrees. Figure 6 shows typical Form D x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form D of aripiprazole hydrochloride comprising the steps of: a) dissolving aripiprazole in tetrahydrofuran; b) adding hydrochloric acid; c) maintaining for about 2 hour to 4 hours at about 15°C to 25°C; d) filtering the solid separated. According to another aspect of the present invention there is provided a pharmaceutical composition comprising crystalline Form I or Form II of aripiprazole. According to another aspect of the present invention there is provided a pharmaceutical composition comprising novel crystalline form of aripiprazole hydrochloride. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a x-ray powder diffraction pattern of crystalline Form I of aripiprazole. Figure 2 is a x-ray powder diffraction pattern of crystalline Form II of aripiprazole. Figure 3 is a x-ray powder diffraction pattern of crystalline Form A of aripiprazole hydrochloride. Figure 4 is a x-ray powder diffraction pattern of crystalline Form B of aripiprazole hydrochloride. Figure 5 is a x-ray powder diffraction pattern of crystalline Form C of aripiprazole hydrochloride. Figure 6 is a x-ray powder diffraction pattern of crystalline Form D of aripiprazole hydrochloride. x-Ray powder diffraction spectrum was measured on a Siemens diffractometer. DETAILED DESCRIPTION OF THE INVENTION According to one aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form I, characterized by an x-ray powder diffraction pattern having peaks expressed as 28 at about 8.7, 11.6, 16.3, 17.7, 18.6, 20.3, 23.4, 24.9 degrees. Figure 1 shows typical Form I x-ray powder diffraction pattern. According to another aspect of the present invention, there is provided a process for preparation of the Form I of aripiprazole. Thus aripiprazole is dissolved in a suitable solvent. The suitable solvent is selected from the group consisting of acetone, ethyl acetate, methanol and ethanol. Aripiprazole obtained by a known method or crystalline Form II of aripiprazole obtained by the process described below may be used. The solution is refluxed for about 30 minutes to 1 hour. The solution is then cooled slowly to about 15°C to 25°C in about 1 hour and maintained for about 2 hour to 4 hours at the same temperature. The separated crystals are filtered and dried to give Form I of aripiprazole. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole, designated as Form II, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 12.7, 15.1, 17.5, 18.2, 18.8, 19.5, 20.6, 21.2, 22.6, 23.3, 24.2, 24.9, 27.6, 30.0, 31.6, 35.8 degrees. Figure 2 shows typical Form II x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form II of aripiprazole, which comprises dissolving aripiprazole in tetrahydrofuran and vacuum drying at about 25°C or spray drying. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form A, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 6.2, 8.5, 11.5, 15.2, 15.5, 16.8, 17.2, 18.3, 18.9, 19.6, 20.6, 21.3, 23.4, 24.1, 24.7, 25.9, 27,5, 28.3, 28.9, 32.8 degrees. Figure 3 shows typical Form A x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form A of aripiprazole hydrochloride. Thus aripiprazole is dissolved in ethahol or isopropyl alcohol. If necessary, the solvent may be heated to effect dissolution of aripiprazole. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 3 hours at about 15°C to 25°C and the separated crystals are filtered and dried to yield Form A of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form B, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.3, 14.8, 16.4, 17.4, 18.7, 19.7, 21.4, 21.9, 23.8, 25.1, 25.9, 29.7 degrees. Figure 4 shows typical Form B x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form B of aripiprazole hydrochloride. Thus aripiprazole is dissolved in a ketonic solvent. If necessary, the solvent may be heated to dissolve aripiprazole. The ketonic solvent is acetone or methyl isobutyl ketone or methyl ethyl ketone; or mixture thereof. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 4 hours at about 15°C to 25°C and the separated crystals are filtered and dried to yield Form B of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form C, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 3.3, 10.3, 14.2, 14.6, 15.1, 16.4, 16.6, 19.4, 20.3, 20.8, 24.5, 24.9, 25.5, 26.4, 26.7, 28.5, 29.3, 30.1 degrees. Figure 5 shows typical Form C x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form C of aripiprazole hydrochloride. Thus aripiprazole is dissolved in an ester solvent. If necessary, the solvent may be heated to effect dissolution of aripiprazole. The ester solvent is selected from the group consisting of ethyl acetate, methyl acetate, ethyl formate and tert-butyl acetate. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for about 1 hour to 4 hours at about 15°C to 25°C and the separated solid is filtered and dried to obtain Form C of aripiprazole hydrochloride. According to another aspect of the present invention, there is provided a novel crystalline form of aripiprazole hydrochloride, designated as Form D, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.0, 14.7, 16.4, 17.4, 19.0, 19.3, 19.8, 21.4, 23.4, 24.7, 25.4 degrees. Figure 6 shows typical Form D x-ray powder diffraction pattern. According to another aspect of the present invention there is provided a process for preparation of the Form D of aripiprazole hydrochloride. Thus aripiprazole is dissolved in tetrahydrofuran. Hydrochloric acid is added to the solution. Hydrochloric acid may be added as an aqueous solution or as a solution in any other solvent; or hydrochloric acid gas may be passed through the solution of aripiprazole. Then the contents are maintained for 2 hour to 4 hours at about 15°C to 25°C and the separated crystals are filtered and dried to produce Form D of aripiprazole hydrochloride. The novel crystalline forms of aripiprazole hydrochloride obtained by the processes described above are very pure. So, aripiprazole with high purity can be obtained by basifying a solution of aripiprazole hydrochloride crystalline form and isolating aripiprazole from the solution by usual processes known in the art. According to another aspect of the present invention there is provided a pharmaceutical composition comprising Form I or Form II of aripiprazole and a pharmaceutical^ acceptable carrier. According to another aspect of the present invention there is provided a pharmaceutical composition comprising crystalline form of aripiprazole hydrochloride and a pharmaceutical^ acceptable carrier. The crystalline form may be Form A, Form B, Form C or Form D. The forms of aripiprazole or aripiprazole hydrochloride may be formulated in a form suitable for oral administration or injection. The examples of pharmaceutical compositions are tablets, capsules, powders, suspensions, emulsions, injections and the like. The following examples will serve to further illustrate the invention. Example 1 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in acetone (42 ml) and refluxed for 30 minutes. The solution is slowly cooled to 25°C in 1 hour and maintained at 25°C for 3 hours. The separated crystals are filtered and dried to give 1 gm of Form I of aripiprazole. Example 2 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran and the solvent is removed by vacuum drying at 25°C for 6 hours to give Form II of aripiprazole in quantitative yield. Example 3 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran and the solvent is removed by spray drying at 25°C for 6 hours to give Form II of aripiprazole in quantitative yield. Example 4 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in methanol (12 ml) and cone, hydrochloric acid (1 ml) is added to the solution. The contents are maintained for 2 hours at 25°C and the separated solid is filtered to give 2 gm of Form A of aripiprazole hydrochloride. Example 5 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in acetone (12 ml) and cone, hydrochloric acid (1ml) is added to the solution. The contents are maintained for 3 hours at 25°C and the separated solid is filtered to give 1.9 gm of Form B of aripiprazole hydrochloride. Example 6 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in ethyl acetate (12 ml). 10% WA/ HCI in ethyl acetate (4 ml) is added to the solution. The solution is maintained at 25°C for 2 hours and the separated crystals are collected by filtration to give 2 gm of Form C of * aripiprazole hydrochloride. Example 7 Aripiprazole (2 gm) (obtained by a process described in US 5,006,528) is dissolved in tetrahydrofuran (12 ml) and cone, hydrochloric acid (1ml) is added to the solution. The contents are maintained for 3 hours at 25°C and the separated solid is collected by filtration to give 2 gm of Form D of aripiprazole hydrochloride. Example 8 Example 1 is repeated using Form II of aripiprazole instead of aripiprazole to give Form I of aripiprazole. Example 9 Example 2 is repeated using Form I of aripiprazole instead of aripiprazole to give Form II of aripiprazole. Example 10 Example 5 is repeated using Form I of aripiprazole instead of aripiprazole to give Form B of aripiprazole hydrochloride. Example 11 Example 7 is repeated using Form II of aripiprazole instead of aripiprazole to give Form D of aripiprazole hydrochloride. We claim: 1. A process for the preparation of aripiprazole crystalline polymorph form II, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 12.7, 15.1, 17.5, 18.2, 18.8, 19.5, 20.6, 21.2, 22.6, 23.3, 24.2, 24.9, 27.6, 30.0, 31,6, 35.8 degrees, comprising the steps of: a) dissolving aripiprazole in tetrahydrofuran; and b) removing the solvent from the solution obtained in step (a) by vacuum drying or spray drying at about 25°C to form aripiprazole crystalline polymorph form II. 2. A process for the preparation of aripiprazole hydrochloride crystalline polymorphs, form B, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.3, 14.8, 16.4, 17.4, 18.7, 19.7, 21.4, 21.9, 23.8, 25.1, 25.9 and 29.7 degrees; form C, characterized by an x- ray powder diffraction pattern having peaks expressed as 29 at about 3,3, 10.3, 14.2, 14.6, 15.1, 16.4, 16.6, 19.4, 20.3, 20.8, 24.5, 24.9, 25.5, 26.4, 26.7, 28.5, 29.3 and 30.1 degrees; form D, characterized by an x-ray powder diffraction pattern having peaks expressed as 29 at about 9.0, 14.7, 16.4, 17.3, 19.0, 19.3, 19.8, 21.4, 23.4, 24.7 and 25.4 degrees; as herein described comprising the steps of: a) dissolving aripiprazole in a specific organic solvent selected from the group consisting of acetone, methyl isobutyl ketone, methyl ethyl ketone, ethyl acetate, methyl acetate, ethyl formate, tert-butyl acetate and tetrahydrofuran. b) adding hydrochloric acid to the solution obtained in step (a); c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; and d) isolating i) aripiprazole hydrochloride crystalline polymorph form B from the solution obtained in step (c) when acetone, methyl isobutyl ketone and methyl ethyl ketone are used as the solvents; ii) aripiprazole hydrochloride crystalline polymorph form C from the solution obtained in step (c) when ethyl acetate, methyl acetate, ethyl formate and tert-butyl acetate are used as the solvents; iii) aripiprazole hydrochloride crystalline polymorph form D from the solution obtained in step (c) when tetrahydrofuran is used as the solvent. 3. The process as claimed in claim 2, wherein the process comprising the steps of: a) dissolving aripiprazole in a ketonic solvent selected from the group consisting of acetone, methyl isobutyl ketone and methyl ethyl ketone ; b) adding hydrochloric acid to the solution obtained in step (a); c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; and d) collecting the separated aripiprazole hydrochloride crystalline form B from the solution obtained in step (c) by filtration. 4. The process as claimed in claim 3, wherein the ketonic solvent is acetone. 5. The process as claimed in claim 2, wherein the process comprising the steps of: a) dissolving aripiprazole in an ester solvent selected from the group consisting of ethyl acetate, methyl acetate, ethyl formate and tert-butyl acetate; b) adding hydrochloric acid to the solution obtained in step (a); c) maintaining for about 1 hour to 4 hours at about 15°C to 25°C; and d) collecting the separated aripiprazole hydrochloride crystalline form C from the solution obtained in step (c) by filtration. 6. The process as claimed in claim 5, wherein the ester solvent is ethyl acetate. 7. The process as claimed in claim 2, wherein the process comprising the steps of: a) dissolving aripiprazole in tetrahydrofuran; b) adding hydrochloric acid to the solution obtained in step (a); c) maintaining for about 2 hour to 4 hours at about 15°C to 25°C; and d) collecting the separated aripiprazole hydrochloride crystalline form D from the solution obtained in step (c) by filtration.

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748-chenp-2003-abstract.pdf

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748-chenp-2003-claims original.pdf

748-chenp-2003-correspondnece-others.pdf

748-chenp-2003-correspondnece-po.pdf

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748-chenp-2003-description(complete) original.pdf

748-chenp-2003-drawings.pdf

748-chenp-2003-form 1.pdf

748-chenp-2003-form 3.pdf

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