Indian Patents. 205867:GELS FORMED BY THE INTERACTION OF POLYVINYLPYRROLIDONE WITH CHITOSAN DERIVATIVES

Title of Invention	GELS FORMED BY THE INTERACTION OF POLYVINYLPYRROLIDONE WITH CHITOSAN DERIVATIVES
Abstract	A dermatologically-compatible composition comprising a hydrophilic gel which comprises a blend of a chitosan and a hydrophilic poly(N-vinyl lactam) having a K value of less than 60.

Full Text	WO 02/02079 PCT/US01/14724 GELS FORMED BY THE INTERACTION OF POLYVINYLPYRROLIDONE WITH-CH1TOSAN DERIVATIVES BACKGROUND OF THE INVENTION This invention relates to the field of poly(N-vinyl lactam)-chitosan gels and more particularly to gels which are absorbent and may be skin adhering, which are flexible and contour-conforming, and which can be used for a variety of applications. The gels of the present invention have K values of below 60. Chitosan is a deacetylated cbitin, and is a linear polysaccharide of deacetylated N-acetyl-D-glucosamine. Chitosan has been used to absorb heavy metals from water and industrial waste streams, and as a dyeing assistant in photographic emulsions. Chitosan derivatives have also been used in cosmetics and conditioning agents, in hair setting lotions and shampoos as, for example, in U.S. Pat. Nos. 4, 134,412 and 4,202,881, when neutralized with acids. Poly(N-vinyl lactam) s such as polyvinylpyrrolidone (PVP) have been used, for example, in pharmaceuticals, in certain types of films and in some cosmetic products. It has been known that polyvinylpyrrolidone forms complexes with polyurethanes to yield hydrophilic blends or alloys. U.S. Pat. No. 4,642,267 describes hydrophilic polymer blends of polyurethane and hydrophilic poly(N-vinyl lactam) prepared in solvent solution to provide slippery coatings when wet and which are water insoluble to some extent once cured by drying. European Patent Application 107,376 describes tacky PVP gels which require the use of ionizing radiation for cross-linking. U.S. Pat. No. 4,646,730 describes a PVP/Silver Sulfadiazine hydrogel dressing in which electron beam radiation is 1 WO 02/02079 PCT/US01/14724 required to cross-link the PVP and form a gel. In addition, magnesium trisilicate, hydrogen peroxide and/or polyacrylic acid are added for color stabilization. It is . apparent that there would be an advantage in making skin-adhering gels in the absence of expensive equipment and/or processing. United States Patent No. 5,420,197 describes poly (N-vinyl lactum)-chitosan gels wherein the K values are at least 60. Ring opening of pyrrolidone groups on PVP was described by H. P. Frank, "The Lactam-Amino Acid Equilibria for Ethylpyrrolidone and Polyvinylpyrrolidone", Journal of Polymer Science 12, 565-576 (1954), and A. Conix and G. Smets, "Ring Opening in Lactam Polymers", J. Poly. Chem.13, 221-229 (1955). The concept of ring-opened pyrrolidone groups is made use of in this invention to unexpectedly attain absorbent gels. It is therefore an object of the invention to provide dermatologically-compatible gels having a hydrophilic absorbent property and K values of less than 60. It is a further object to produce gels with K values of less than 60 without a need for expensive equipment and/or processing. It is another object to provide gels of poly(N-vinyl lactam) and chitosan derivatives with K values of less man 60 which can be used in a variety of products such as cavity dressings, drug delivery patches, face masks, wound dressings and prostheses. SUMMARY OF THE INVENTION Accordingly, there is provided a stable, hydrophilic gel which comprises a blend of acid-neutralized chitosan and a poly(N-vinyl lactam), with or without a 2 WO 02/02079 PCT/US01/14724 plasticizer, the poly(N-vinyl lactam) having a K value of less than about 60 and mole equivalents of acid groups of at least about 1.4. The gel may be formed into a wound packing or cavity dressing where, unlike hydrocolloid dressings, it is able to absorb exudate without losing its gel structure. It can also be utilized as a drug carrier for transdermal devices and for use in dry skin masks to deliver moisturizers to the skin. It can also be used in prosthetic devices such as breast implants. The poly(N-vinyl lactam) is preferably a polyvinylpyrrolidone having mole equivalents of acid groups of at least about 1.4 formed by ring opening of pyrrolidone groups. The gel is prepared by mixing aqueous poly(N-vinyl lactam) solution and acid-neutralized chitosan in aqueous solution at a poly(N-vinyl lactam)/chitosan weight ratio of from about 12/1 to about 1/1, preferably from about 10/1 to about 5/1, to form a blend at about 5 wt. % to 40 wt. % total polymer concentration, preferably from about 12.5 wt. % to about 25 wt. % polymer concentration, and allowing the blend to cure until a gel is formed. The gel preferably includes at least one additional ingredient which may be releasable from the gel. Preferably the releasable ingredient is a moisturizer, drug or other bio-effecting or body-treating material. Preferred products for which the gel can be used are cavity-filling wound dressings, other wound and burn dressings, drug delivery systems, cosmetic masks, prostheses and wraps. For a better understanding of the present invention, together with other and further objects, reference is made to the following description, and its scope will be pointed out in the appended claims. 3 WO 02/02079 PCT/US01/14724 DESCRIPTION OF THE PREFERRED EMBODIMENTS It has been found that poly(N-vinyl lactam) such as polyvinylpyrrolidone (PVP), with a degree of ring-opened pyrrolidone groups, forms hydrophilic gels with chitosans. The gels are flexible and transparent or translucent and may be used alone or with various additives. The gels can be used for wound packing, wound and burn dressings, drug delivery systems, prostheses, cosmetic face and nail wraps, and other applications where the high absorption capacity of the gel and the high heat capacity and transport capacity of water as part of the hydrophilic gel can be utilized. These gels may have either a tacky quality or a non-tacky quality. Chitosan, a natural product, is derived from chitin. Chitin is an unbranched linear polysaccharide of N-acetyl-D-glucosamine units linked by b-1,4 bonds. It is a polymer of glucose in which the hydroxyl group on C-2 is replaced by the N-acetylamino group -NHCOCH3. In chitosan, the acetyl group is absent. Therefore, chitosan is a deacetylated chitin. Chitosan contains approximately 7% nitrogen and is structurally similar to cellulose. Chitin occurs in nature in the exoskeletons of arthropods such as crabs, lobsters and shrimp. Chitin can be obtained from these sources as an amorphous powder after dissolution of the calcium carbonate with mineral acids and removal of the proteins. It is also found in some fungi, algae and yeast. Chitosan becomes soluble in water when protonated with acids. The polymer thus formed is positively charged and thus more likely to interact with negatively charged surfaces like skin and hair. Chitosan derivatives are commercially available as, for example, chitosan neutralized with pyrrolidone carboxylic acid available as Kytamer PCA from Amerchol Corporation; carboxymethyl sodium salt of chitosan available as Chitisol from Muto Corporation; chitosan neutralized with glutamic acid available as 4 WO 02/02079 PCT/US01/14724 Seacure+210 from Protan Corporation; N,0-carboxymethyl chitosan available from Nova Chem Ltd., Canada; and un-neutralized chitosan available from Tokyo Kasei Inc. Suitable chitosan derivatives for this invention are the dermatologically-compatible salts of chitosan such as those with pyrrolidone carboxylic acid, glutamic acid, acetate, etc., and also N,O-carboxymethyl chitosan. Suitable poly(N-vinyl lactams) have a K value of less than about 60, preferably less than about 45, most preferably from about 25 to about 35, and optimally about 30. The K value represents kinematic viscosity. It is a measure of the resistive flow of a fluid under the. influence of gravity. The K value is a function of molecular weight. The K value is derived from viscosity measurements and is calculated according to Eikentscher's formula described by Kline, G. M., "Polyvinylpyrrolidone", Modern Plastics p 157 (Nov. 1945) and is also described in General Aniline & Film Corporation Technical Bulletin 7583-033. At the same K value or molecular weight, the level of ring-opened poly(N-vinyl lactam) is an important consideration in determining whether a gel forms. In the invention, poly N-vinyl lactams containing above certain levels of ring-opened pyrrolidone groups, when mixed with certain solutions of neutralized chitosans, form gels which may be mildly tacky. The term tacky is intended to mean having the property of being sticky to the touch or adhesive to a degree that the gel is capable of sticking to the skin while being easily removable when removal is desired. The term poly(N-vinyl lactam) as used herein shall be understood to include homopolymers, copolymers and terpolymers of N-vinyl lactams such as N- vinylpyrrolidone, N-vinylbutyrolactara, N-vinylcaprolactam, and the like, as well as the foregoing prepared with minor amounts, for example, up to about 20 weight percent, of one or a mixture of other vinyl monomers copolymerizable with the N- vinyl lactams. Copolymers or terpolymers of poly(N-vinyl-lactam) may comprise N- vinyl-lactam monomers such as vinyl pyrrolidone copolymerized with monomers containing a vinyl functional group such as acrylates, hydroxyalkylacrylates, 5 WO 02/02079 PCT/US01/14724 methacrylates, acrylic acid or methacrylic acid, and acrylamides. Of the poIy(N-vinyI lactam) homopolymers, the polyvinylpyrrolidone (PVP) homopolymers are preferred. Of the poly(N- vinyl lactam) copolymers, vinyl pyrrolidone, acrylamide copolymers are preferred. A suitable poly(N-vinyl lactam) terpolymer is vinylpyrrolidone, vinylcaprolactam, dimethylaminoethyl methacrylate. A variety of polyvinylpyrrolidones are commercially available. It is important, however, for the poly(N-vinyl lactam) to contain a degree of ring-opened lactam groups. A lactam may be considered to be a cyclic amide produced from an amino acid through the elimination of a molecule of water from the —COOH and —NH2 groups. A lactam, therefore, contains a —NH--CO-- group in a ring. An N-vinyl lactam has a vinyl group at the ring nitrogen and the monomer can be polymerized through the vinyl group. In a ring-opened poly(N-vinyl lactam), the vinyl backbone may be considered to remain essentially intact, but some lactam rings are opened to make available —COOH groups. The availability of these —COOH groups may be measured through base titration to determine the mole equivalents of base per mole of acid groups in a specific poly(N-vinyl lactam). Because the polymer backbone remains essentially intact, different poly(N-vinyl lactams) having the same molecular weight or K value may have different levels of ring openings. The poly(N-vinyl lactams) useful in forming the ge]s in the invention have a mole equivalent/mole of acid groups greater than about 1.4, preferably greater than about 2.0. In the absence of opened lactam rings, the gel does not form. The poly(N-vinyl lactams) are preferably of relatively low molecular weight as indicated by a K value less than about 60. Biological systems break down poly (N-vinyl lactams) which have such K values. Ring opening in poly(N-vinyl lactams) may be effected by heating a solution of the poly(N-vinyl lactam) at a temperature of from about 50°C to about 120° C, with from about 60° C to about 100°C preferred, at pressure from about 15 psi to about 150 psi for from about one half hour to about 10 days, with from about one hour to about 24 hours preferred. The solvent for the solution is preferably aqueous and may include a small amount of a weak base such as dilute ammonium hydroxide or 6 WO 02/02079 PCT/US01/14724 dilute sodium hydroxide to result in a solution which is slightly basic, e.g. having a pH of about 7-9, with about 7-8 or 7-8.5 preferred. If time saving is an important consideration as in commercial operations, ring opening may be carried out, for example, for shorter periods of time in a reactor under conditions of high temperature and pressure, e.g. 200°C at 50 psi. To form the gel, the poly(N-vinyl lactam) is mixed or blended with neutralized chitosan. At certain ratios of PVP/chitosan derivatives, a mixture of these two components forms a highly water-swellable gel within a short time of mixing. The gel may be prepared by dissolving the poly(N-vinyl lactam) such as polyvinylpyrrolidone in aqueous solution, then adding an aqueous solution of neutralized chitosan with sufficient agitation to attain a homogenous mixture. The solvent used for the gel preparation is preferably substantially aqueous. For example, the gels may be prepared in water or in hydroalcohols such as water/isopropyl alcohol and water/ethanol. The gels form at a ratio of PVP/chitosan of from about 12/1 to about 1/1, preferably from about 10/1 to about 5/1. At higher PVP to chitosan ratios gels are formed but may lead to a sticky residue and may contain uncomplexed PVP which will leach out in water. The total polymer concentration as well as the ratios of the two polymer components at which the gel is made shows an effect on the consistency of the gel, which becomes softer at lower concentrations. Decreasing the total polymer concentration, or decreasing the concentration of the PVP alone, also leads to softer gels at a given PVP-chitosan ratio. The gels may be made with a total polymer content ranging from about 5 to about 40 wt. % solids, preferably from about 12.5 wt. % to about 25 wt. % solids. At lower solids levels, gels may form but they are not as consistent. The blend may be allowed to cure for a time of from a few seconds to about 20 minutes. The time and temperature for curing are not critical. For purposes of convenience, ambient temperature may be used but the time can be shortened at elevated temperatures. The term gel is intended to mean viscous or semisolid and jelly-like. 7 WO 02/02079 PCT/US01/14724 The preferred gels are stable and therefore maintain their physical integrity after absorbing large quantities of liquid. The gels can be sterilized by radiation sterilization. The gels are hydrophilic and capable of absorbing many times their weight in water or at least twice their weight in water. For practical application as described herein, a gel absorbs, for example, from about 4 to 10 times its dry weight in water or saline solution (0.9% NaCI), depending on the ratio of PVP/chitosan. For example, at a ratio of PVP/chitosan of about 2/1, the gel absorbs about 4 times its dry weight (i.e. solids weight) in saline solution; at a ratio of 10/1, it can absorb about 10 times its dry weight in saline solution. While the exact nature of the mechanism by which the gel forms is not known, and while it is not intended to be bound by theory, it is believed to be caused by pervasive and tight hydrogen bonds between chains. The presence of the ring-opened pyrrolidones, in some undetermined way, plays an imperative role in achieving this goal. Wetting, dispersing agents or surfactants as are known in the art, such as block copolymers of ethylene oxide and propylene oxide, may be added to the blends in an amount of from about 1 to about 5 weight percent, preferably from about 1 to about 3 weight percent, to reduce adherence to the skin. Glycerine in an amount of from about 5 to about 50 weight percent, preferably from about 10 to about 30 weight percent may be added to the gel preparation to increase tack and pliability after drying. The glycerine is preferably mixed into the PVP solution prior to adding neutralized chitosan solution. Propylene glycol or low molecular weight polyethylene glycol may also be used. Many different types of additional materials may be incorporated into the gels including organic salts, inorganic salts at low levels, alcohols, amines, polymer 8 WO 02/02079 PCT/US01/14724 lattices, fillers, surfactants, pigments, dyes, fragrances and so forth as long as they do not interfere with gel formation. Many of these materials can be released from the gel. The gels of this invention are especially useful as carriers for a wide variety of releasable biologically-active substances having curative or therapeutic value for human or non-human animals. Included among the biologically-active materials which are suitable for incorporation into the gels of the invention are hypnotics, sedatives, tranquilizers, anticonvulsants, muscle relaxants, analgesics, antipyretic agents, anti-inflammatory agents, local anesthetics, antispasmodics, antiulcer agents, antivirals, antibacterials, antifungals, sympamomimetic agents, cardiovascular agents, antitumor agents, and so forth. A biologically-active substance is added in pharmaceutically-active amounts. Particularly preferred as biologically-active additives are nitroglycerine, scopolamine, pilocarpine, ergotamine tartrate, phenylpropanolamine, and theophylline; also antimicrobials tetracycline, neomycin, oxytetracycline, triclosan, sodium cefazolin, silver sulfadiazine, and also salicylates such as methylsalicylate and salicylic acid, nicotinates such as methyl nicotinate, capsicum and benzocaine. When the gel is to be used, for example, for cosmetic treatment, hydrating agents such as sodium pyrrolidine carboxylic acid may be added. For a hydrating purpose, however, the large amount of water alone which can be absorbed by the hydrophilic gel serves a hydrating function to the skin. Water-soluble and water-insoluble additives such as those described above may be initially mixed with the aqueous solvent before the gel preparation is begun, may be mixed with the aqueous solution of poly(N-vinyl lactam) or mixed with the aqueous solution of neutralized chitosan during the gel preparation. Water-soluble ingredients are preferably mixed in with the PVP prior to admixing with chitosan. Many water-insoluble ingredients can be mixed with chitosan prior to adding to PVP. One can also emulsify water insolubles by adding surfactants to either the PVP or chitosan. Alternatively, additives may be similarly mixed into the gel preparation after 9 WO 02/02079 PCT/US01/14724 the poly(N-vinyl lactam) is blended with the chitosan. Additives may also be applied to the surface of a gel dressing, for example, by spraying, dipping, brushing or rolling. The gels can be used to make adsorbent wound packing agents or dressings, skin masks or wraps, drug delivery patches, prosthetic devices, such as breast implants, and dry film products. When the gel is used as a wound packing or cavity-filling wound dressing, it advantageously provides the desired properties of such dressings, such as (1) biocompatability; (2) ability to conform to a wound cavity; (3) non-adherence to the wound; (4) absorbs exudate; (5) removable in one piece from the wound; (6) holds its physical integrity when swollen with exudate; (7) is not too sticky for handling. When used as a skin-bydrating mask, the gel has excellent hydrating capacity, advantageously contains no alcohol, and is easily and cleanly removed. When made into a dry film and used as a skin mask, it provides a flexible, clear, hydrophilic film which adheres to the skin when wetted with water. The film can retain active moisturizers and other ingredients close to the skin, helping in their delivery. The film can also be easily peeled off after a period of time without leaving residues. To obtain the products of the invention, the gel may be packaged by itself in a mold, in a dry film form, or as a two-part system which requires mixing prior to use; or may be provided on a substrate and covered with a release liner to prevent the gel from sticking to itself. The release liner is removed prior to application to skin. The substrate may fulfill one or several functions including providing reinforcement, providing a gas and liquid barrier, providing a support with air permeability, providing protection for the gel and the area of treatment, etc. Substrate selection to provide the desired properties is known to those skilled in the art. 10 WO 02/02079 PCT/US01/14724 The gel may be coated or spread onto a backing or substrate by any means known in the art. The gel can be combined with and adhered to a virtually unlimited variety of substrates or backings including resins, metal foils, woven and non-woven webs of natural and synthetic fibers, etc. A backing which provides gas and liquid barrier properties may be a polymer film such as polyurethane. Desirable composites with the gel may also be made using films of polyester, polyvinyl alcohol, or polyvinylidene chloride. When the gel has a barrier substrate, the resulting structure has particular utility as a wound and burn dressing. Moisture is kept in and excess exudate is absorbed to promote healing but bacteria are prevented from entering the wound or burn area, and microbial stasis may be maintained through the incorporation of an anti-microbial agent into the gel to prevent infection. For ease of use, the tacky gel on a backing is covered with a release liner which may be a silicone-coated film or polyethylene. The gel may be coated onto the backing so that the gel occupies all or part of the backing surface. If the gel occupies part of the backing surface, non-gel coated areas of the backing may be provided with an additional adhesive. A dressing of this type is positioned on the skin so that the additional skin adhesive comes into contact with intact skin while the absorbent gel contacts a wound. The additional adhesive provides a dressing with staying power when the absorbent gel has become substantially saturated with wound exudate thus losing some of its adhesiveness through a dilution effect. In still another embodiment, the gel may be used in cosmetic preparations such as face masks and nail wraps. The gel serves a hydrating function with or without a backing and a cosmetic effect may be enhanced with the incorporation of other ingredients. A kit for a cosmetic gel may comprise a ready-made gel or two components: a poly(N-vinyl lactam) component and a chitosan component. Other cosmetic agents such as hydrating agents, fragrances, etc. can also be supplied to the ready-made gel or to either component. For use, the components may be mixed and applied. The gel advantageously can be easily peeled off after use. It shall be 11 WO 02/02079 PCT/US01/14724 understood that the term cosmetic means a preparation intended to enhance or improve physical appearance. In a further embodiment, fragrances may be incorporated into the gel. When the gel is kept moist in a suitable vented container, the fragrance is slowly released as an air freshener. The following examples are intended to illustrate but not limit the invention. EXAMPLE 1 To 10.0 grams of a 40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 10.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue. EXAMPLE 2 To 10.0 grams of a 40% water solution of PVP (Kollidon K 15, BASF Corp.) was added 10.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel has good adhesion to skin, but was easily removed without leaving a residue. 12 WO 02/02079 PCT/US01/14724 EXAMPLE 3 To 10.0 grams of a 40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 5.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put is excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue. EXAMPLE 4 To 10.0 grams of a40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 10.0 grams of a 3% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue. EXAMPLE 5 To 10.0 grams of a 50% water solution of PVP (Kollidon K 30, BASF Corp.) was added 5.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue. 13 WO 02/02079 PCT/US01/14724 EXAMPLE 6 To 5.0 grams of 40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 10.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue. EXAMPLE 7 To 10.0 grams of a 40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 5.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and coated in a thickness of 1.0mm on a polyester substrate. The coating was dried in an oven to form a 0.05 mm thick dried film that can be die cut to specific shapes. The film when it comes in contact with saline, swells and absorbs 500% of the fluid without disintegrating or dissolving. 14 WE CLAIM: 1. A dermatologically-compatible composition comprising a hydrophilic gel which comprises a blend of a chitosan and a hydrophilic poly(N-vinyl lactam) having a K value of less than 60. 2. A composition as claimed in claim 1 wherein the K value is from about 25 to about 35. 3. The composition as claimed in claim 1 wherein the poly(N-vinyl lactam) comprises polyvinylpyrrolidone homopolymer, copolymer or terpolymer. 4. The composition as claimed in claim 1 wherein the gel comprises a poly(N-vinyl lactam)/chitosan weight ratio of from about 12/1 to about 1/1. 5. The composition as claimed in claim 1 wherein the gel is prepared in an aqueous solution at a total polymer concentration of from about 5 weight percent to about 40 weight percent poly(N-vinyl lactam) and chitosan. 6. The composition as claimed in claim 5 wherein the solution comprises water or a mixture of water and alcohol. 7. The composition as claimed in claim 1 wherein the poly(N-vinyl lactam) has mole equivalents of available acid groups of at least 1.4. 8. The composition as claimed in claim 1 wherein the chitosan is neutralized, 9. The composition as claimed in claim 1 which comprises at least one substrate. 10. The composition as claimed in claim 9 wherein the substrate is selected from a group consisting of polymer film, collagen film, woven fabric, and non-woven fabric. 11. The composition as claimed in claim 9 wherein the substrate is a polyurethane film. 12. The composition as claimed in claim 9 wherein the substrate is a polyester film. 13. The composition as claimed in claim 9 wherein the substrate is stretchable. 14. The composition as claimed in claim 9 wherein the substrate is a release liner. 15. The composition as claimed in claim 1 wherein the gel comprises at least one additional ingredient. 16. The composition as claimed in claim 15 wherein the additional ingredient is a surfactant. 15 17. The composition as claimed in claim 15 wherein the additional ingredient is releasable from the gel. 18. The composition as claimed in claim 17 wherein the additional ingredient is a fragrance. 19. The composition as claimed in claim 17 wherein the additional ingredient is a biologically-active material. 20. The composition as claimed in claim 19 wherein the additional ingredient is selected from a group consisting of nitroglycerine, scopolamine, pilocarpine, ergotamine tartrate, phenylpropanolamine, theophylline, tetracycline, neomycin, oxytetracycline, triclosan, sodium cefazolin, silver sulfadiazine, salicylates, nicotinates, capsaicin and benzocaine. 21. A method for preparing a stable, mildly tacky, hydrophilic gel comprising mixing an aqueous dissolved poly(N-vinyl lactam) homopolymer or copolymer having a K value of less than about 60 and an aqueous solution of chitosan in a poly(N-vinyl lactam)/chitosan ratio of from about 12/1 to about 1/1, with a total polymer content above 5 weight percent to produce a blend, and allowing the blend to cure for a time of about 10 seconds to about 2 hours until a gel is formed. 22. The method as claimed in claim 21 which comprises treating a poly(N-vinyl lactam) to increase mole equivalents of acid groups to above 1.4 by heating the poly (N-vinyl lactam) in aqueous solution at a temperature of from about 50 degree. C. to about 200.degree. C, at a pressure of from about 15 psi to about 150 psi, for about one-half hour to about 10 days. 23. The method as claimed in claim 22 wherein the aqueous solution has a pH of from about 4 to about 8. 24. The method as claimed in claim 21 which comprises adding a biologically-active material to the blend. 25. The method as claimed in claim 24 wherein the biologically-active material is an antimicrobial agent. 26. The method as claimed in. claim 21 wherein the blend is formed into a dressing by coating or casting the blend onto a substrate. 27. The method as claimed in claim 26 wherein the blend is covered with a second substrate which is a release liner. 28. The method as claimed in claim 21 wherein the blend is formed into a dressing by casting two separate slabs of gel onto two separate substrates, applying a solution of a biologically-active material to a surface of one of the slabs, and compressing the slabs together so that the biologically active material is located between the slabs. 16 29. The method as claimed in claim 28 wherein the biologically-active material is selected from the group consisting of salicylates, nicotinates and capsaicin. 30. The composition as claimed in claim 1 in the form of a product selected from a group consisting of wound packings, wound dressings, burn dressings, drug delivery dressings, dry films, cosmetic mask dressings and cosmetic wrap dressings. 31. The composition as claimed in claim 30 in the form of a wound packing or cavity dressing without a substrate. 32. The composition as claimed in claim 1 in the form of a dry film. 33. A stable, hydrophilic gel which comprises a blend of chitosan and a hydrophilic poly(N-vinyl lactam) having a K value of less than 60, the chitosan and poly(N-vinyl lactam) combined in a chitosan/poly(N-vinyl lactam) weight ratio from about 12/1 to about 1/1 in an aqueous solution at a total polymer concentration of at least five weight percent. 34. The composition as claimed in claim 1 wherein the chitosan comprises a member of the group consisting of pyrrolidone carboxylic acid, glutamic acid, acetate and carboxymethyl. 17 A dermatologically-compatible composition comprising a hydrophilic gel which comprises a blend of a chitosan and a hydrophilic poly(N-vinyl lactam) having a K value of less than 60.

Full Text

WO 02/02079 PCT/US01/14724
GELS FORMED BY THE INTERACTION OF POLYVINYLPYRROLIDONE
WITH-CH1TOSAN DERIVATIVES
BACKGROUND OF THE INVENTION
This invention relates to the field of poly(N-vinyl lactam)-chitosan gels and more particularly to gels which are absorbent and may be skin adhering, which are flexible and contour-conforming, and which can be used for a variety of applications. The gels of the present invention have K values of below 60.
Chitosan is a deacetylated cbitin, and is a linear polysaccharide of deacetylated N-acetyl-D-glucosamine. Chitosan has been used to absorb heavy metals from water and industrial waste streams, and as a dyeing assistant in photographic emulsions. Chitosan derivatives have also been used in cosmetics and conditioning agents, in hair setting lotions and shampoos as, for example, in U.S. Pat. Nos. 4, 134,412 and 4,202,881, when neutralized with acids.
Poly(N-vinyl lactam) s such as polyvinylpyrrolidone (PVP) have been used, for example, in pharmaceuticals, in certain types of films and in some cosmetic products.
It has been known that polyvinylpyrrolidone forms complexes with polyurethanes to yield hydrophilic blends or alloys. U.S. Pat. No. 4,642,267 describes hydrophilic polymer blends of polyurethane and hydrophilic poly(N-vinyl lactam) prepared in solvent solution to provide slippery coatings when wet and which are water insoluble to some extent once cured by drying.
European Patent Application 107,376 describes tacky PVP gels which require
the use of ionizing radiation for cross-linking. U.S. Pat. No. 4,646,730 describes a
PVP/Silver Sulfadiazine hydrogel dressing in which electron beam radiation is
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required to cross-link the PVP and form a gel. In addition, magnesium trisilicate, hydrogen peroxide and/or polyacrylic acid are added for color stabilization. It is . apparent that there would be an advantage in making skin-adhering gels in the absence of expensive equipment and/or processing.
United States Patent No. 5,420,197 describes poly (N-vinyl lactum)-chitosan gels wherein the K values are at least 60.
Ring opening of pyrrolidone groups on PVP was described by H. P. Frank, "The Lactam-Amino Acid Equilibria for Ethylpyrrolidone and Polyvinylpyrrolidone", Journal of Polymer Science 12, 565-576 (1954), and A. Conix and G. Smets, "Ring Opening in Lactam Polymers", J. Poly. Chem.13, 221-229 (1955). The concept of ring-opened pyrrolidone groups is made use of in this invention to unexpectedly attain absorbent gels.
It is therefore an object of the invention to provide dermatologically-compatible gels having a hydrophilic absorbent property and K values of less than 60.
It is a further object to produce gels with K values of less than 60 without a need for expensive equipment and/or processing.
It is another object to provide gels of poly(N-vinyl lactam) and chitosan derivatives with K values of less man 60 which can be used in a variety of products such as cavity dressings, drug delivery patches, face masks, wound dressings and prostheses.
SUMMARY OF THE INVENTION
Accordingly, there is provided a stable, hydrophilic gel which comprises a blend of acid-neutralized chitosan and a poly(N-vinyl lactam), with or without a
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plasticizer, the poly(N-vinyl lactam) having a K value of less than about 60 and mole equivalents of acid groups of at least about 1.4. The gel may be formed into a wound packing or cavity dressing where, unlike hydrocolloid dressings, it is able to absorb exudate without losing its gel structure. It can also be utilized as a drug carrier for transdermal devices and for use in dry skin masks to deliver moisturizers to the skin. It can also be used in prosthetic devices such as breast implants.
The poly(N-vinyl lactam) is preferably a polyvinylpyrrolidone having mole equivalents of acid groups of at least about 1.4 formed by ring opening of pyrrolidone groups.
The gel is prepared by mixing aqueous poly(N-vinyl lactam) solution and acid-neutralized chitosan in aqueous solution at a poly(N-vinyl lactam)/chitosan weight ratio of from about 12/1 to about 1/1, preferably from about 10/1 to about 5/1, to form a blend at about 5 wt. % to 40 wt. % total polymer concentration, preferably from about 12.5 wt. % to about 25 wt. % polymer concentration, and allowing the blend to cure until a gel is formed.
The gel preferably includes at least one additional ingredient which may be releasable from the gel. Preferably the releasable ingredient is a moisturizer, drug or other bio-effecting or body-treating material.
Preferred products for which the gel can be used are cavity-filling wound dressings, other wound and burn dressings, drug delivery systems, cosmetic masks, prostheses and wraps.
For a better understanding of the present invention, together with other and further objects, reference is made to the following description, and its scope will be pointed out in the appended claims.
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DESCRIPTION OF THE PREFERRED EMBODIMENTS
It has been found that poly(N-vinyl lactam) such as polyvinylpyrrolidone (PVP), with a degree of ring-opened pyrrolidone groups, forms hydrophilic gels with chitosans. The gels are flexible and transparent or translucent and may be used alone or with various additives. The gels can be used for wound packing, wound and burn dressings, drug delivery systems, prostheses, cosmetic face and nail wraps, and other applications where the high absorption capacity of the gel and the high heat capacity and transport capacity of water as part of the hydrophilic gel can be utilized. These gels may have either a tacky quality or a non-tacky quality.
Chitosan, a natural product, is derived from chitin. Chitin is an unbranched linear polysaccharide of N-acetyl-D-glucosamine units linked by b-1,4 bonds. It is a polymer of glucose in which the hydroxyl group on C-2 is replaced by the N-acetylamino group -NHCOCH3. In chitosan, the acetyl group is absent. Therefore, chitosan is a deacetylated chitin. Chitosan contains approximately 7% nitrogen and is structurally similar to cellulose. Chitin occurs in nature in the exoskeletons of arthropods such as crabs, lobsters and shrimp. Chitin can be obtained from these sources as an amorphous powder after dissolution of the calcium carbonate with mineral acids and removal of the proteins. It is also found in some fungi, algae and yeast.
Chitosan becomes soluble in water when protonated with acids. The polymer thus formed is positively charged and thus more likely to interact with negatively charged surfaces like skin and hair.
Chitosan derivatives are commercially available as, for example, chitosan neutralized with pyrrolidone carboxylic acid available as Kytamer PCA from Amerchol Corporation; carboxymethyl sodium salt of chitosan available as Chitisol from Muto Corporation; chitosan neutralized with glutamic acid available as
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Seacure+210 from Protan Corporation; N,0-carboxymethyl chitosan available from Nova Chem Ltd., Canada; and un-neutralized chitosan available from Tokyo Kasei Inc. Suitable chitosan derivatives for this invention are the dermatologically-compatible salts of chitosan such as those with pyrrolidone carboxylic acid, glutamic acid, acetate, etc., and also N,O-carboxymethyl chitosan.
Suitable poly(N-vinyl lactams) have a K value of less than about 60, preferably less than about 45, most preferably from about 25 to about 35, and optimally about 30. The K value represents kinematic viscosity. It is a measure of the resistive flow of a fluid under the. influence of gravity. The K value is a function of molecular weight. The K value is derived from viscosity measurements and is calculated according to Eikentscher's formula described by Kline, G. M., "Polyvinylpyrrolidone", Modern Plastics p 157 (Nov. 1945) and is also described in General Aniline & Film Corporation Technical Bulletin 7583-033. At the same K value or molecular weight, the level of ring-opened poly(N-vinyl lactam) is an important consideration in determining whether a gel forms.
In the invention, poly N-vinyl lactams containing above certain levels of ring-opened pyrrolidone groups, when mixed with certain solutions of neutralized chitosans, form gels which may be mildly tacky. The term tacky is intended to mean having the property of being sticky to the touch or adhesive to a degree that the gel is capable of sticking to the skin while being easily removable when removal is desired.
The term poly(N-vinyl lactam) as used herein shall be understood to include
homopolymers, copolymers and terpolymers of N-vinyl lactams such as N-
vinylpyrrolidone, N-vinylbutyrolactara, N-vinylcaprolactam, and the like, as well as
the foregoing prepared with minor amounts, for example, up to about 20 weight
percent, of one or a mixture of other vinyl monomers copolymerizable with the N-
vinyl lactams. Copolymers or terpolymers of poly(N-vinyl-lactam) may comprise N-
vinyl-lactam monomers such as vinyl pyrrolidone copolymerized with monomers
containing a vinyl functional group such as acrylates, hydroxyalkylacrylates,
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methacrylates, acrylic acid or methacrylic acid, and acrylamides. Of the poIy(N-vinyI lactam) homopolymers, the polyvinylpyrrolidone (PVP) homopolymers are preferred. Of the poly(N- vinyl lactam) copolymers, vinyl pyrrolidone, acrylamide copolymers are preferred. A suitable poly(N-vinyl lactam) terpolymer is vinylpyrrolidone, vinylcaprolactam, dimethylaminoethyl methacrylate. A variety of polyvinylpyrrolidones are commercially available. It is important, however, for the poly(N-vinyl lactam) to contain a degree of ring-opened lactam groups.
A lactam may be considered to be a cyclic amide produced from an amino acid through the elimination of a molecule of water from the —COOH and —NH2 groups. A lactam, therefore, contains a —NH--CO-- group in a ring. An N-vinyl lactam has a vinyl group at the ring nitrogen and the monomer can be polymerized through the vinyl group. In a ring-opened poly(N-vinyl lactam), the vinyl backbone may be considered to remain essentially intact, but some lactam rings are opened to make available —COOH groups. The availability of these —COOH groups may be measured through base titration to determine the mole equivalents of base per mole of acid groups in a specific poly(N-vinyl lactam). Because the polymer backbone remains essentially intact, different poly(N-vinyl lactams) having the same molecular weight or K value may have different levels of ring openings. The poly(N-vinyl lactams) useful in forming the ge]s in the invention have a mole equivalent/mole of acid groups greater than about 1.4, preferably greater than about 2.0. In the absence of opened lactam rings, the gel does not form. The poly(N-vinyl lactams) are preferably of relatively low molecular weight as indicated by a K value less than about 60. Biological systems break down poly (N-vinyl lactams) which have such K values.
Ring opening in poly(N-vinyl lactams) may be effected by heating a solution of the poly(N-vinyl lactam) at a temperature of from about 50°C to about 120° C, with from about 60° C to about 100°C preferred, at pressure from about 15 psi to about 150 psi for from about one half hour to about 10 days, with from about one hour to about 24 hours preferred. The solvent for the solution is preferably aqueous and may include a small amount of a weak base such as dilute ammonium hydroxide or
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dilute sodium hydroxide to result in a solution which is slightly basic, e.g. having a pH of about 7-9, with about 7-8 or 7-8.5 preferred. If time saving is an important consideration as in commercial operations, ring opening may be carried out, for example, for shorter periods of time in a reactor under conditions of high temperature and pressure, e.g. 200°C at 50 psi.
To form the gel, the poly(N-vinyl lactam) is mixed or blended with neutralized chitosan. At certain ratios of PVP/chitosan derivatives, a mixture of these two components forms a highly water-swellable gel within a short time of mixing.
The gel may be prepared by dissolving the poly(N-vinyl lactam) such as polyvinylpyrrolidone in aqueous solution, then adding an aqueous solution of neutralized chitosan with sufficient agitation to attain a homogenous mixture. The solvent used for the gel preparation is preferably substantially aqueous. For example, the gels may be prepared in water or in hydroalcohols such as water/isopropyl alcohol and water/ethanol. The gels form at a ratio of PVP/chitosan of from about 12/1 to about 1/1, preferably from about 10/1 to about 5/1. At higher PVP to chitosan ratios gels are formed but may lead to a sticky residue and may contain uncomplexed PVP which will leach out in water. The total polymer concentration as well as the ratios of the two polymer components at which the gel is made shows an effect on the consistency of the gel, which becomes softer at lower concentrations. Decreasing the total polymer concentration, or decreasing the concentration of the PVP alone, also leads to softer gels at a given PVP-chitosan ratio. The gels may be made with a total polymer content ranging from about 5 to about 40 wt. % solids, preferably from about 12.5 wt. % to about 25 wt. % solids. At lower solids levels, gels may form but they are not as consistent. The blend may be allowed to cure for a time of from a few seconds to about 20 minutes. The time and temperature for curing are not critical. For purposes of convenience, ambient temperature may be used but the time can be shortened at elevated temperatures. The term gel is intended to mean viscous or semisolid and jelly-like.
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The preferred gels are stable and therefore maintain their physical integrity after absorbing large quantities of liquid. The gels can be sterilized by radiation sterilization. The gels are hydrophilic and capable of absorbing many times their weight in water or at least twice their weight in water. For practical application as described herein, a gel absorbs, for example, from about 4 to 10 times its dry weight in water or saline solution (0.9% NaCI), depending on the ratio of PVP/chitosan. For example, at a ratio of PVP/chitosan of about 2/1, the gel absorbs about 4 times its dry weight (i.e. solids weight) in saline solution; at a ratio of 10/1, it can absorb about 10 times its dry weight in saline solution.
While the exact nature of the mechanism by which the gel forms is not known, and while it is not intended to be bound by theory, it is believed to be caused by pervasive and tight hydrogen bonds between chains. The presence of the ring-opened pyrrolidones, in some undetermined way, plays an imperative role in achieving this goal.
Wetting, dispersing agents or surfactants as are known in the art, such as block copolymers of ethylene oxide and propylene oxide, may be added to the blends in an amount of from about 1 to about 5 weight percent, preferably from about 1 to about 3 weight percent, to reduce adherence to the skin.
Glycerine in an amount of from about 5 to about 50 weight percent, preferably from about 10 to about 30 weight percent may be added to the gel preparation to increase tack and pliability after drying. The glycerine is preferably mixed into the PVP solution prior to adding neutralized chitosan solution. Propylene glycol or low molecular weight polyethylene glycol may also be used.
Many different types of additional materials may be incorporated into the gels including organic salts, inorganic salts at low levels, alcohols, amines, polymer
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lattices, fillers, surfactants, pigments, dyes, fragrances and so forth as long as they do not interfere with gel formation. Many of these materials can be released from the gel.
The gels of this invention are especially useful as carriers for a wide variety of releasable biologically-active substances having curative or therapeutic value for human or non-human animals. Included among the biologically-active materials which are suitable for incorporation into the gels of the invention are hypnotics, sedatives, tranquilizers, anticonvulsants, muscle relaxants, analgesics, antipyretic agents, anti-inflammatory agents, local anesthetics, antispasmodics, antiulcer agents, antivirals, antibacterials, antifungals, sympamomimetic agents, cardiovascular agents, antitumor agents, and so forth. A biologically-active substance is added in pharmaceutically-active amounts.
Particularly preferred as biologically-active additives are nitroglycerine, scopolamine, pilocarpine, ergotamine tartrate, phenylpropanolamine, and theophylline; also antimicrobials tetracycline, neomycin, oxytetracycline, triclosan, sodium cefazolin, silver sulfadiazine, and also salicylates such as methylsalicylate and salicylic acid, nicotinates such as methyl nicotinate, capsicum and benzocaine. When the gel is to be used, for example, for cosmetic treatment, hydrating agents such as sodium pyrrolidine carboxylic acid may be added. For a hydrating purpose, however, the large amount of water alone which can be absorbed by the hydrophilic gel serves a hydrating function to the skin.
Water-soluble and water-insoluble additives such as those described above
may be initially mixed with the aqueous solvent before the gel preparation is begun,
may be mixed with the aqueous solution of poly(N-vinyl lactam) or mixed with the
aqueous solution of neutralized chitosan during the gel preparation. Water-soluble
ingredients are preferably mixed in with the PVP prior to admixing with chitosan.
Many water-insoluble ingredients can be mixed with chitosan prior to adding to PVP.
One can also emulsify water insolubles by adding surfactants to either the PVP or
chitosan. Alternatively, additives may be similarly mixed into the gel preparation after
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the poly(N-vinyl lactam) is blended with the chitosan. Additives may also be applied to the surface of a gel dressing, for example, by spraying, dipping, brushing or rolling.
The gels can be used to make adsorbent wound packing agents or dressings, skin masks or wraps, drug delivery patches, prosthetic devices, such as breast implants, and dry film products.
When the gel is used as a wound packing or cavity-filling wound dressing, it advantageously provides the desired properties of such dressings, such as (1) biocompatability; (2) ability to conform to a wound cavity; (3) non-adherence to the wound; (4) absorbs exudate; (5) removable in one piece from the wound; (6) holds its physical integrity when swollen with exudate; (7) is not too sticky for handling.
When used as a skin-bydrating mask, the gel has excellent hydrating capacity, advantageously contains no alcohol, and is easily and cleanly removed.
When made into a dry film and used as a skin mask, it provides a flexible, clear, hydrophilic film which adheres to the skin when wetted with water. The film can retain active moisturizers and other ingredients close to the skin, helping in their delivery. The film can also be easily peeled off after a period of time without leaving residues.
To obtain the products of the invention, the gel may be packaged by itself in a mold, in a dry film form, or as a two-part system which requires mixing prior to use; or may be provided on a substrate and covered with a release liner to prevent the gel from sticking to itself. The release liner is removed prior to application to skin. The substrate may fulfill one or several functions including providing reinforcement, providing a gas and liquid barrier, providing a support with air permeability, providing protection for the gel and the area of treatment, etc. Substrate selection to provide the desired properties is known to those skilled in the art.
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The gel may be coated or spread onto a backing or substrate by any means known in the art. The gel can be combined with and adhered to a virtually unlimited variety of substrates or backings including resins, metal foils, woven and non-woven webs of natural and synthetic fibers, etc. A backing which provides gas and liquid barrier properties may be a polymer film such as polyurethane. Desirable composites with the gel may also be made using films of polyester, polyvinyl alcohol, or polyvinylidene chloride. When the gel has a barrier substrate, the resulting structure has particular utility as a wound and burn dressing. Moisture is kept in and excess exudate is absorbed to promote healing but bacteria are prevented from entering the wound or burn area, and microbial stasis may be maintained through the incorporation of an anti-microbial agent into the gel to prevent infection. For ease of use, the tacky gel on a backing is covered with a release liner which may be a silicone-coated film or polyethylene.
The gel may be coated onto the backing so that the gel occupies all or part of the backing surface. If the gel occupies part of the backing surface, non-gel coated areas of the backing may be provided with an additional adhesive. A dressing of this type is positioned on the skin so that the additional skin adhesive comes into contact with intact skin while the absorbent gel contacts a wound. The additional adhesive provides a dressing with staying power when the absorbent gel has become substantially saturated with wound exudate thus losing some of its adhesiveness through a dilution effect.
In still another embodiment, the gel may be used in cosmetic preparations such as face masks and nail wraps. The gel serves a hydrating function with or without a backing and a cosmetic effect may be enhanced with the incorporation of other ingredients. A kit for a cosmetic gel may comprise a ready-made gel or two components: a poly(N-vinyl lactam) component and a chitosan component. Other cosmetic agents such as hydrating agents, fragrances, etc. can also be supplied to the ready-made gel or to either component. For use, the components may be mixed and applied. The gel advantageously can be easily peeled off after use. It shall be
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understood that the term cosmetic means a preparation intended to enhance or improve physical appearance.
In a further embodiment, fragrances may be incorporated into the gel. When the gel is kept moist in a suitable vented container, the fragrance is slowly released as an air freshener.
The following examples are intended to illustrate but not limit the invention.
EXAMPLE 1
To 10.0 grams of a 40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 10.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue.
EXAMPLE 2
To 10.0 grams of a 40% water solution of PVP (Kollidon K 15, BASF Corp.) was added 10.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel has good adhesion to skin, but was easily removed without leaving a residue.
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EXAMPLE 3
To 10.0 grams of a 40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 5.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put is excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue.
EXAMPLE 4
To 10.0 grams of a40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 10.0 grams of a 3% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue.
EXAMPLE 5
To 10.0 grams of a 50% water solution of PVP (Kollidon K 30, BASF Corp.) was added 5.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue.
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EXAMPLE 6
To 5.0 grams of 40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 10.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and it quickly became gelatinous. The gel, when put in excess water or saline at room temperature absorbed additional liquid but did not dissolve or disintegrate. The gel had good adhesion to skin, but was easily removed without leaving a residue.
EXAMPLE 7
To 10.0 grams of a 40% water solution of PVP (Kollidon K 30, BASF Corp.) was added 5.0 grams of a 2% aqueous solution of chitosan (Sino Lion). The mixture was stirred for one minute and coated in a thickness of 1.0mm on a polyester substrate.
The coating was dried in an oven to form a 0.05 mm thick dried film that can be die cut to specific shapes. The film when it comes in contact with saline, swells and absorbs 500% of the fluid without disintegrating or dissolving.
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WE CLAIM:
1. A dermatologically-compatible composition comprising a hydrophilic gel which comprises a blend of a chitosan and a hydrophilic poly(N-vinyl lactam) having a K value of less than 60.
2. A composition as claimed in claim 1 wherein the K value is from about 25 to about 35.
3. The composition as claimed in claim 1 wherein the poly(N-vinyl lactam) comprises polyvinylpyrrolidone homopolymer, copolymer or terpolymer.
4. The composition as claimed in claim 1 wherein the gel comprises a poly(N-vinyl lactam)/chitosan weight ratio of from about 12/1 to about 1/1.
5. The composition as claimed in claim 1 wherein the gel is prepared in an aqueous solution at a total polymer concentration of from about 5 weight percent to about 40 weight percent poly(N-vinyl lactam) and chitosan.
6. The composition as claimed in claim 5 wherein the solution comprises water or a mixture of water and alcohol.
7. The composition as claimed in claim 1 wherein the poly(N-vinyl lactam) has mole equivalents of available acid groups of at least 1.4.
8. The composition as claimed in claim 1 wherein the chitosan is neutralized,
9. The composition as claimed in claim 1 which comprises at least one substrate.
10. The composition as claimed in claim 9 wherein the substrate is selected from a group consisting of polymer film, collagen film, woven fabric, and non-woven fabric.
11. The composition as claimed in claim 9 wherein the substrate is a polyurethane film.
12. The composition as claimed in claim 9 wherein the substrate is a polyester film.
13. The composition as claimed in claim 9 wherein the substrate is stretchable.
14. The composition as claimed in claim 9 wherein the substrate is a release liner.
15. The composition as claimed in claim 1 wherein the gel comprises at least one additional ingredient.
16. The composition as claimed in claim 15 wherein the additional ingredient is a surfactant.
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17. The composition as claimed in claim 15 wherein the additional ingredient is releasable from the gel.
18. The composition as claimed in claim 17 wherein the additional ingredient is a fragrance.
19. The composition as claimed in claim 17 wherein the additional ingredient is a biologically-active material.
20. The composition as claimed in claim 19 wherein the additional ingredient is selected from a group consisting of nitroglycerine, scopolamine, pilocarpine, ergotamine tartrate, phenylpropanolamine, theophylline, tetracycline, neomycin, oxytetracycline, triclosan, sodium cefazolin, silver sulfadiazine, salicylates, nicotinates, capsaicin and benzocaine.
21. A method for preparing a stable, mildly tacky, hydrophilic gel comprising mixing an aqueous dissolved poly(N-vinyl lactam) homopolymer or copolymer having a K value of less than about 60 and an aqueous solution of chitosan in a poly(N-vinyl lactam)/chitosan ratio of from about 12/1 to about 1/1, with a total polymer content above 5 weight percent to produce a blend, and allowing the blend to cure for a time of about 10 seconds to about 2 hours until a gel is formed.
22. The method as claimed in claim 21 which comprises treating a poly(N-vinyl lactam) to increase mole equivalents of acid groups to above 1.4 by heating the poly (N-vinyl lactam) in aqueous solution at a temperature of from about 50 degree. C. to about 200.degree. C, at a pressure of from about 15 psi to about 150 psi, for about one-half hour to about 10 days.
23. The method as claimed in claim 22 wherein the aqueous solution has a pH of from about 4 to about 8.
24. The method as claimed in claim 21 which comprises adding a biologically-active material to the blend.
25. The method as claimed in claim 24 wherein the biologically-active material is an antimicrobial agent.
26. The method as claimed in. claim 21 wherein the blend is formed into a dressing by coating or casting the blend onto a substrate.
27. The method as claimed in claim 26 wherein the blend is covered with a second substrate which is a release liner.
28. The method as claimed in claim 21 wherein the blend is formed into a dressing by casting two separate slabs of gel onto two separate substrates, applying a solution of a biologically-active material to a surface of one of the slabs, and compressing the slabs together so that the biologically active material is located between the slabs.
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29. The method as claimed in claim 28 wherein the biologically-active material is selected from the group consisting of salicylates, nicotinates and capsaicin.
30. The composition as claimed in claim 1 in the form of a product selected from a group consisting of wound packings, wound dressings, burn dressings, drug delivery dressings, dry films, cosmetic mask dressings and cosmetic wrap dressings.
31. The composition as claimed in claim 30 in the form of a wound packing or cavity dressing without a substrate.
32. The composition as claimed in claim 1 in the form of a dry film.
33. A stable, hydrophilic gel which comprises a blend of chitosan and a hydrophilic poly(N-vinyl lactam) having a K value of less than 60, the chitosan and poly(N-vinyl lactam) combined in a chitosan/poly(N-vinyl lactam) weight ratio from about 12/1 to about 1/1 in an aqueous solution at a total polymer concentration of at least five weight percent.
34. The composition as claimed in claim 1 wherein the chitosan comprises a member of the group consisting of pyrrolidone carboxylic acid, glutamic acid, acetate and carboxymethyl.
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A dermatologically-compatible composition comprising a hydrophilic gel which comprises a blend of a chitosan and a hydrophilic poly(N-vinyl lactam) having a K value of less than 60.

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Patent Number

205867

Indian Patent Application Number

IN/PCT/2002/01580/KOL

PG Journal Number

15/2007

Publication Date

13-Apr-2007

Grant Date

13-Apr-2007

Date of Filing

26-Dec-2002

Name of Patentee

HYDROMER INC.

Applicant Address

35, INDUSTRIAL PARKWAY, BRANCHBURG, NJ 08876, UNITED STATES OF AMERICA

Inventors:

#	Inventor's Name	Inventor's Address
1	LORENZ DONALD H	12 RADEL PLACE, BASKING RIDGE, NJ 07920, U.S.A.
2	LEE CONNIE C	44 WESSON TERRACE, NORTHBOROUGH, MA 01532-1960 U.S.A.

PCT International Classification Number

A 61 K 47/30

PCT International Application Number

PCT/US01/14724

PCT International Filing date

2001-05-08

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	09/610,398	2000-07-05	U.S.A.