Title of Invention

PROCESS FOR THE PREPARATION OF PYRAZOLO [1,5-B] PYRIDAZINE DERIVATIVES

Abstract

The invention provides a process for preparing a compound of formula (I) and pharmaceutically acceptable derivatives thereof in which: R?0¿ is halogen, C¿1-6?alkyl, C¿1-6?alkoxy, C¿1-6?alkoxy substituted by one or more fluorine atoms, or O(CH¿2?)¿n?NR?4¿R?5¿; R?1¿ and R?2¿ are independently selected from H, C¿1-6?alkyl, C¿1-6?alkyl substituted by one or more fluorine atoms, C¿1-6?alkoxy, C¿1-6?hydroxyalkyl, SC¿1-6?alkyl, C(O)H, C(O)C¿1-6?alkyl, C¿1-6?alkylsulphonyl, C¿1-6?alkoxy substituted by one or more fluorine atoms, O(CH¿2?)¿n?CO¿2?C¿1-6?alkyl, O(CH¿2?¿n?SC¿1-6?alkyl, (CH¿2?)¿n?NR?4¿R?5¿, (CH¿2?)¿n?SC¿1-6?alkyl or C(O)NR?4¿R?5¿; with the proviso that when R?0¿ is at the 4-position and is halogen, at least one of R?1¿ and R?2¿ is C¿1-6?alkylsulphonyl, C¿1-6?alkoxy substituted by one or more fluorine atoms, O(CH¿2?)¿n?CO¿2?C¿1-6?alkyl, O(CH¿2?)¿n?SC¿1-6?alkyl, (CH¿2?)¿n?NR?4¿R?5¿ or (CH¿2?)¿n?SC¿1-6?alkyl, C(O)NR?4¿R?5¿; R?3¿ is C¿1-6?alkyl or NH¿2?; R?4¿ and R?5¿ are independently selected from H, or C¿1-6?alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; and n is 1-4;which comprises oxidising a corresponding compound of formula (II) or an isomer thereof.

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in-pct-2002-00826-mum-cancelled pages(12-7-2005).pdf

in-pct-2002-00826-mum-claims(18-6-2002).pdf

in-pct-2002-00826-mum-claims(amended)-(12-7-2005).pdf

in-pct-2002-00826-mum-claims(granted)-(17-5-2006).pdf

in-pct-2002-00826-mum-correspondence(23-3-2006).pdf

in-pct-2002-00826-mum-correspondence(ipo)-(17-5-2006).pdf

in-pct-2002-00826-mum-correspondence(ipo)-(9-8-2006).pdf

in-pct-2002-00826-mum-description(complete)-(18-6-2002).pdf

in-pct-2002-00826-mum-description(granted)-(17-5-2006).pdf

in-pct-2002-00826-mum-form 1(12-7-2005).pdf

in-pct-2002-00826-mum-form 1(18-6-2002).pdf

in-pct-2002-00826-mum-form 19(19-12-2004).pdf

in-pct-2002-00826-mum-form 2(18-6-2002).pdf

in-pct-2002-00826-mum-form 2(granted)-(17-5-2006).pdf

in-pct-2002-00826-mum-form 2(title page)-(18-6-2002).pdf

in-pct-2002-00826-mum-form 2(title page)-(granted)-(17-5-2006).pdf

in-pct-2002-00826-mum-form 3(12-7-2005).pdf

in-pct-2002-00826-mum-form 3(18-6-2002).pdf

in-pct-2002-00826-mum-form 5(18-6-2002).pdf

in-pct-2002-00826-mum-petition under rule 137(12-7-2005).pdf

in-pct-2002-00826-mum-power of authority(4-9-2002).pdf

in-pct-2002-00826-mum-wo international publication report(18-6-2006).pdf