| Title of Invention | PROCESS FOR MANUFACTURING SIMVASTATIN |
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| Abstract | This invention describes the synthesis of simvastatin from lovastatin by converting the lovastatin to lova amide using a secondary amine and subsequent reaction with a metal amide base generated from n-butyl lithium and pyrrolidine and followed by treatment with methyl iodide to give desired C-methylated intermediate. This intermediate was further transformed to the final product, simvastatin. This method of production consumes lesser quantities of metal amide, gives fewer side reactions and a lowered overall cost of manufacture of simvastatin than other procedures reported. |
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in-pct-2002-0583-che abstract-duplicate.pdf
in-pct-2002-0583-che abstract.pdf
in-pct-2002-0583-che claims-duplicate.pdf
in-pct-2002-0583-che claims.pdf
in-pct-2002-0583-che correspondence-others.pdf
in-pct-2002-0583-che correspondence-po.pdf
in-pct-2002-0583-che description (complete)-duplicate.pdf
in-pct-2002-0583-che description (complete).pdf
in-pct-2002-0583-che form-1.pdf
in-pct-2002-0583-che form-13.pdf
in-pct-2002-0583-che form-19.pdf
in-pct-2002-0583-che form-26.pdf
in-pct-2002-0583-che form-3.pdf
in-pct-2002-0583-che form-5.pdf
| Patent Number | 199164 | |||||||||||||||
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| Indian Patent Application Number | IN/PCT/2002/583/CHE | |||||||||||||||
| PG Journal Number | 23/2006 | |||||||||||||||
| Publication Date | 09-Jun-2006 | |||||||||||||||
| Grant Date | 27-Feb-2006 | |||||||||||||||
| Date of Filing | 22-Apr-2002 | |||||||||||||||
| Name of Patentee | M/S. BIOCON LIMITED | |||||||||||||||
| Applicant Address | 20th K.M. Hosur Road, Hebbagodi, Bangalore 561 229 | |||||||||||||||
Inventors:
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| PCT International Classification Number | C07D 309/30 | |||||||||||||||
| PCT International Application Number | PCT/IN1999/000063 | |||||||||||||||
| PCT International Filing date | 1999-11-11 | |||||||||||||||
PCT Conventions:
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