Title of Invention

PROCESS FOR THE PRODUCTION OF 4-(HETEROARYL-METHYL)-HALOGEN-1(2H)-PHTHALAZINONES

Abstract

Process for the production of 4-(heteroaryl-methyi)-halogen-1 (2H)-phthalazinones of general formula I in which Rl = fluorine, chlorine, bromine or hydrogen and Ar = pyridine, pyrazine or pyrrolidine, characterized in that substituted phthalidyl-3- triphenylphosphonium salts of general formula II in which R1 = fluorine, chlorine, bromine or hydrogen, are reacted with aldehydes of general formula EI Ar-CHO HI, in which Ar = pyridine, pyrazine or pyrimidine, in the presence of a base and subsequent reaction with hydrazine hydrate and optionally under acidic conditions.

Full Text

FORM 2 THE PATENTS ACT 1970 [39 OF 1970] & THE PATENTS RULES, 2003 COMPLETE SPECIFICATION [See Section 10; rule 13] 'PROCESS FOR THE PRODUCTION OF 4-(HETEROARYL-METHYL)-HALOGEN-1 (2H)-PHTHALAZINONES" SCHERING AKTIENGESELLSCHAFT, a German company of Mullerstrasse 178, 13342 Berlin, Germany, The following specification particularly describes the invention and the manner in which it is to be performed: The invention relates to a process for the production of 4-(heteroaryl-methyl)-halogen-1 (2H)-phthalazinones. 4-(Heteroaryl-methyl)-halogen-l(2H)-phthalazinone, especially the 4-(4-pyridylmethyl)-l(2H)-phthalazinone, are valuable intermediate products in the production of phthalazine derivatives, which are distinguished by pharmacologically advantageous properties, such as, e.g., inhibition of angiogenesis (WO 98/35958), inhibition of cGMP phosphodiesterase (EP 0 722 936), inflammation-inhibiting and antihypertensive action (DE OS 2 021 195) and thus open up new therapeutic possibilities, especially for treating cancer and heart disease. The production of, for example, 4-(4-pyridylmethyl)-l(2H)-phthalazinone is carried out according to previously known methods by the reaction of phthalic acid anhydride and 4-methylpyridine at about 200°C and subsequent reaction of the condensation product that is obtained (y-pyrophthalone) with excess hydrazine at 130°C (DE AS 1 061 788). Drawbacks of these methods are the low yield ( As an alternative, 4-(4-pyridylmethyl)-l(2H)-phthalazinone can be produced by condensation of phthalide with 4-pyridine aldehyde in the presence of sodium methylate and subsequent reaction of the 2-(4(lH)-pyridinylidene)-4,5,6,7-tetrahydroindene-l,3-dione that is obtained with a large excess (16 equivalents) of hydrazine at 130°C (WO 98/35958). The yield over the two stages is about 40% of theory. In the case of these methods, the handling of the large excess of carcinogenic hydrazine at a temperature that -%- lies above the decomposition temperature of hydrazine (about 120°C) is very problematical in nature. In this case, it is very unlikely that the very low boundary value for hydrazine in air (MAK 0.008 ppm) or in waste waters can be maintained in the working-up and isolation of the product. From WO 99/32456, a reaction is known that is performed, however, with about lOOx excess of hydrazine and at a reaction temperature that is close to the decomposition temperature of hydrazine (about 120°C). On an industrial scale, such a process is very problematical in nature. The yield is also comparatively low. It would therefore be desirable to have a viable process for the production of 4-(heteroaryl-methyl)-halogen-1 (2H)-phthalazinones, especially 4-(4-pyridylmethyl)-l(2H)-phthalazones, which avoids the technical problems (reaction at 200°C), safety problems (heating of hydrazine to 130°C) and environmental problems (large excess of hydrazine) of the known processes. The known drawbacks are now overcome by the process according to the invention. The subject of the invention is thus a process for the production of 4-(heteroaryl-methyl)-halogen-l(2H)-phthalazinones of general formula I in which R1 = fluorine, chlorine, bromine or hydrogen and Ar = pyridine, pyrazine or pyrimidine, characterized in that substituted phthalidyl-3- triphenylphosphonium salts of general formula II in which R1 = fluorine, chlorine, bromine or hydrogen, are reacted with aldehydes of general formula III Ar-CHO III, in which Ar = pyridine, pyrazine or pyrimidine, in the presence of a base and subsequent reaction with hydrazine hydrate and optionally under acidic conditions. Radical R1, if the latter should stand for halogen, can be in any position on the phenyl ring within the pyrazinone system, thus in 1-, 2-, 3- or 4-position. As suitable Ar radicals, pyridine, pyrimidine or pyrazine can be mentioned. Suitable aldehydes are, for example, 2-, 3- or 4-pyridine-aldehyde, 2-methyl-4-pyridine-aldehyde, 3-methyl-4-pyridine-aldehyde, 4-pyrimidine-aldehyde, 5-pyrimidine-aldehyde, 3-pyrazine-aldehyde or 4-pyrazine-aldehyde. Thus, for example by the reaction of phthalidyl-3-triphenylphosphonium salt with 4-pyridine aldehyde in the presence of a base (basic adjuvant), subsequent reaction with hydrazine hydrate and acid treatment of the reaction mixture. In particular, subsequent reaction with 1-1.1 equivalents of hydrazine hydrate and subsequent treatment of the -4- reaction mixture with 0.1-0.3 equivalent of acetic acid anhydride triggered by the reaction in a solvent of phthalidyl-3-triphenylphosphonium salts with 4-pyridine aldehyde in the presence of a base (basic adjuvant). To isolate the product, the reaction mixture is mixed with an aqueous acid, the solvent is distilled off, the precipitated triphenylphosphine is filtered off, and the filtrate is alkalized. The desired product is precipitated in this case and is obtained at a very high purity and excellent yield (95-98% of theory) after filtration and drying. As a solvent for the reaction, organic solvents, such as, for example, tetrahydrofuran, dimethoxyethane, methanol, ethanol or dimethylformamide, are suitable. As bases, organic bases, such as amines, e.g., triethylamine, ethyldiisopropylamine, or inorganic bases such as potassium carbonate, sodium carbonate, magnesium carbonate or magnesium hydroxides are used. The reaction time for the reaction of phthalidyl-3-triphenylphosphonium salts is 1 hour at 40°C and for the reaction with hydrazine is 7-14 hours at 50-70°C. r- The phthalidyl-3-triphenylphosphonium salts (bromides and chlorides) that are used as educts are easily accessible according to methods that are known in the literature (J. Organometallic Chem. 1972, 391; J. Org. Chem. 1973.4164). Advantages of the process according to the invention compared to the processes that are known from the prior art are the less severe reaction conditions, significantly better yield (> 90%) and especially the use of stoichiometric amounts of hydrazine. The reactions proceed fully and in a closed system, so that before the working-up, no hydrazine can be detected in the reaction mixture (single-pot reaction). The threat posed by this carcinogen is thus avoided. Embodiments: Example 1 Production of 4-(4-PyridylmethyI)-phthalazinone 500 g of phthalidyl-3-triphenylphosphonium chloride (1.160 mol) is suspended in 2250 ml of tetrahydrofuran (THF). At 5°C, 110.7 ml of pyridine-4-aldehyde (124.2 g, 1.160 mol) is added, and then 161.7 ml of triethylamine (117.4 g, 1.160 mol) is metered into the white suspension. After the addition is completed, the reaction mixture is stirred for 1 hour at 40°C, then mixed with 62.0 ml of hydrazine hydrate (63.9 g, 1.276. mol) and stirred for 8 hours at 70°C. Then, 32.7 ml of acetic acid anhydride (35.5 g, 0.348 mol) is added, and the stirring is continued for 2.5 hours at 20°C. Then, the reaction mixture is mixed first with 1500 ml of water, then with 367 ml of 4 M H2S04 solution. About 2500 ml of THF/water is distilled off from this reaction solution in a vacuum. The suspension that is obtained is filtered via a glass frit. The filtrate is mixed with 50% sodium /* v 6 hydroxide solution up to a pH of 8.0 (about 185 ml). The precipitated product is filtered off, washed with 450 ml of water and dried at 60°C. 264.2 g (96% of theory) of a slightly yellowish solid is obtained. Melting point: 193-194°C. EI-MS (M+H)'242. The production of the other derivatives is carried out analogously to this example. WE CLAIM: 1. Process for the production of 4-(heteroaryl-methyi)-halogen-1 (2H)-phthalazinones of general formula I in which Rl = fluorine, chlorine, bromine or hydrogen and Ar = pyridine, pyrazine or pyrrolidine, characterized in that substituted phthalidyl-3- triphenylphosphonium salts of general formula II in which R1 = fluorine, chlorine, bromine or hydrogen, are reacted with aldehydes of general formula EI Ar-CHO HI, in which Ar = pyridine, pyrazine or pyrimidine, in the presence of a base and subsequent reaction with hydrazine hydrate and optionally under acidic conditions. A 2. Process as claimed in claim 1, wherein as a base, amines or alkali hydroxide or alkaline-earth hydroxides are used. 3. Process as claimed in claim 1, wherein the reaction with hydrazine hydrate and subsequent treatment of the reaction mixture is carried out with acetic acid anhydride or acetic acid. 4. Process as claimed in claim 1, wherein the reaction with 1-1.1 equivalents of hydrazine hydrate and subsequent treatment of the reaction mixture is carried out with 0.1-0.3 equivalent of acetic acid anhydride. Dated this 27th day of May, 2002 (RANJNA MEHTA DUTT) OF REMFRY & SAGAR ATTORNEY FOR THE APPLICANTS

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