Title of Invention	"PHENANTHROINDOLIZIDINE DERIVATIVE AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT"
Abstract	A novel compound having an excellent NFKB inhibitory-effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like,* R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like; R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.

Title of Invention

"PHENANTHROINDOLIZIDINE DERIVATIVE AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT"

Abstract

A novel compound having an excellent NFKB inhibitory-effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like,* R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like; R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.

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Patent Number

278375

Indian Patent Application Number

2896/DELNP/2011

PG Journal Number

53/2016

Publication Date

23-Dec-2016

Grant Date

21-Dec-2016

Date of Filing

20-Apr-2011

Name of Patentee

KABUSHIKI KAISHA YAKULT HONSHA

Applicant Address

1-19, HIGASHI SHINBASHI 1-CHOME, MINATO-KU, TOKYO 105-8660, JAPAN

Inventors:

#	Inventor's Name	Inventor's Address
1	TAKASHI IKEDA	C/O KABUSHIKI KAISHA YAKULT HONSHA, 1-19, HIGASHI SHINBASHI 1-CHOME, MINATO-KU, TOKYO 105-8660, JAPAN
2	SEIGO SAWADA	C/O KABUSHIKI KAISHA YAKULT HONSHA, 1-19, HIGASHI SHINBASHI 1-CHOME, MINATO-KU, TOKYO 105-8660, JAPAN
3	TAKASHI YAEGASHI	C/O KABUSHIKI KAISHA YAKULT HONSHA, 1-19, HIGASHI SHINBASHI 1-CHOME, MINATO-KU, TOKYO 105-8660, JAPAN
4	SHUSUKE HASHIMOTO	C/O KABUSHIKI KAISHA YAKULT HONSHA, 1-19, HIGASHI SHINBASHI 1-CHOME, MINATO-KU, TOKYO 105-8660, JAPAN
5	RYUTA YAMAZAKI	C/O KABUSHIKI KAISHA YAKULT HONSHA, 1-19, HIGASHI SHINBASHI 1-CHOME, MINATO-KU, TOKYO 105-8660, JAPAN

PCT International Classification Number

C07D 471/04

PCT International Application Number

PCT/JP09/005593

PCT International Filing date

2009-10-23

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	2008-273556	2008-10-23	Japan