Title of Invention

PRODRUG OF BENZOQUINOLIZINE-2-CARBOXYLIC ACID

Abstract The instant invention relates to novel prodrugs of optically pure benzoquinolizine-2-carboxylic acid, and pharmaceutical compositions that include the prodrugs. In particular, the present invention relates to the sulfonic acid salt of L-alanine and L-valine prodrugs of s- (-) -9- fluoro 6,7-dihydro-8- (4-hydroxypiperidin-1-yl) -5-methy-1-oxo-1H, 5H-benzo[i, j] quinolizine-2-carboxylic acid. The compounds and compositions of the invention can be used to treat bacterial Gram-positive, Gram-negative and anaerobic infections, especially infections caused by resistant Gram-positive organism and Gram-negative organism, mycobacterial infections and emerging nosocomial pathogen infections.
Full Text

Documents:


Patent Number 267210
Indian Patent Application Number 321/MUM/2006
PG Journal Number 27/2015
Publication Date 03-Jul-2015
Grant Date 02-Jul-2015
Date of Filing 07-Mar-2006
Name of Patentee WOCKHARDT LIMITED
Applicant Address WOCKHARDT TOWERS, BANDRA-KURLA COMPLEX, BANDRA-(EAST), MUMBAI.
Inventors:
# Inventor's Name Inventor's Address
1 MAHESH VITHALBHAI PATEL WOCKHARDT LIMITED, WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210.
2 VIJAYA NARAYAN DESAI WOCKHARDT LIMITED, WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210.
3 PRASAD KESHAV DESHPANDE WOCKHARDT LIMITED, WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210.
4 RAVINDRA DATTATRAYA YEOLE WOCKHARDT LIMITED, WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210.
5 RAJESH PRABHAKAR KALE WOCKHARDT LIMITED, WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210.
6 PRASAD KESHAV DESHPANDE WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210
7 RAVINDRA DATTATRAYA YEOLE WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210
8 MAHESH SHRIRAM PHANSALKAR WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210
9 MOHAMMAD ALAM JAFRI WOCKHARDT RESEARCH CENTRE D-4, MIDC, CHIKALTHANA AURANGABAD-431 210
PCT International Classification Number A61K31/4745
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 NA