Title of Invention

SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES

Abstract

The use of a compound of formula I, wherein Y is a single bond, C=O, C=S or S(O)m where m is 0, 1 or 2; R" , R2 , R3 , R4 , R8 and Ra are specified organic groups and p is 0, 1, 2, 3, 4, 5 or 6; q is 0, 1, 2, 3, 4, 5 or 6; provided that when p is 2 then q is not 2; p+q is 1, 2, 3, 4, 5 or 6; or salts or N-oxides thereof or compositions containing them and their using incontrolling insects, acarines, nematodes or molluscs. Novel compounds are also provided.

Full Text

SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES The present invention relates to spiroindoline derivatives, to processes for preparing them, to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control insect, acarine, mollusc and nematode pests. Spiroindoline derivatives with pharmaceutical properties are disclosed in for example US5763471, WO9825605, WO9429309, W09828297 and WO9964002. Synthetic routes to selected compounds with pharmaceutical properties are described in Proc. Natl. Acad. Sci. USA (1995), 92, 7001, Tetrahedron (1997), 53, 10983 and Tetrahedron Letters (1997), 3*8, 1497. It has now surprisingly been found that certain spiroindolines have insecticidal properties. The present invention therefore provides a method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I): wherein Y is a single bond, C=0, C=S or S(0)m where m is 0, 1 or 2; R1 is hydrogen, optionally substituted alkyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, aminocarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocyclyloxy, cyano, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, formyl, optionally substituted heterocyclyl, optionally substituted alkylthio, NO or NR13R14 where R13 and R14 are independently hydrogen, COR15, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl or R13 and R14 together with the N atom to which they are attached form a group -N=C(R16)-NR17R1S; R15 is H, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted aryloxy optionally substituted heteroaryl, optionally substituted heteroaryloxy or NR19R20; R16, R17 and R18 are each independently H or lower alkyl; R19 and R20 are independently optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R and R are independently hydrogen, halogen, cyano, optionally substituted alkyl, optionally substituted alkoxy or optionally substituted aryl; each R4 is independently halogen, nitro, cyano, optionally substituted Q-s alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted C3-7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio or R R N where R and R22 are, independently, hydrogen, C1-8 alkyl, C3.7 cycloalkyl, C3_6 alkenyl, C3-6 alkynyl, C3.7 cycloalkyl(C1-4)alkyl, C2-e haloalkyl, Ci-6 alkoxy(Ci.6)alkyl, C\.e alkoxycarbonyl or R21 and R together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from 0, N or S and which may be optionally substituted by one or two C1-6 alkyl groups, or 2 adjacent groups R together with the carbon atoms to which they are attached form a 4, 5, 6,or 7 membered carbocyclic or heterocyclic ring which may be optionally substituted by halogen; n is 0, 1, 2, 3 or 4; each Ra is independently hydrogen, halogen, hydroxy, cyano, optionally substituted Ci_g alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted C3.7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio, optionally substituted arylthio or R* R~ N where R and R are, independently, hydrogen, C\.$ alkyl, C3.7 cycloalkyl, C3.6 alkenyl, C3.6 alkynyl, C3-7 cycloalkyl(C1-4)aIkyl, C2-6 haloalkyl, Q-6 alkoxy(Ci-6)alkyl, C1-6 alkoxycarbonyl or R and R together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two Cue alkyl groups, or two Ra groups attached to the same carbon atom are =0 or two Ra groups attached to adjacent carbon atoms form a bond, or two Ra groups together with the carbon atom to which they are attached form a three- to seven-membered ring, that may be saturated or unsaturated, and that may contain one or two hetero atoms selected from the group consisting of N, O and S, and which may be optionally substituted by one or two C1-6 alkyl groups; or two Ra groups together form a group -CH2-, -CH=CH- or -CH2CH2; p is 0, 1,2, 3, 4, 5 or 6; q is 0, 1, 2, 3, 4, 5 or 6; provided that when p is 2 then q is not 2; p+q is 1, 2, 3, 4, 5 or 6; R is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl or optionally substituted alkenylcarbonyl; or salts or N-oxides thereof. The compounds of formula (I) may exist in different geometric or optical isomers or tautomeric forms. This invention covers all such isomers and tautomers and mixtures thereof in all proportions as well as isotopic forms such as deuterated compounds. Each alkyl moiety either alone or as part of a larger group (such as alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl) is a straight or brauched chain and is, for example, methyl, ethyl n-propyl, n-butyl, n-pentyl, n-hexyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl orneo-pentyl. The alkyl groups are suitably Ci to Ci2 alkyl groups, but are preferably CI-CIQ, more preferably Ci-Cg, even more preferably preferably C1-C6 and most preferably C1-C4 alkyl groups. When present, the optional substituents on an alkyl moiety (alone or as part of a larger group such as alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylammocarbonyl, dialkylaminocarbonyl) include one or more of halogen, nitro, cyano, NCS-, C3.7 cycloalkyl (itself optionally substituted withC1-6 alkyl or halogen), C5-7 cycloalkenyl (itself optionally substituted withC1-6 alkyl or halogen), hydroxy, C1-10 alkoxy, C2-10 alkoxy(Cuo)alkoxys tri(C1-4)alkylsilyl(CK6)alkoxy7 C1-6 alkoxycarbonyl(C1_1o)alkoxy, C1-10 haloalkoxy, aryl(Ct-4)-alkoxy (where the aryl group is optionally substituted), C3.7 cycloalkyloxy (where the cycloalkyl group is optionally substituted with C1-6 alkyl or halogen), C2-10 alkenyloxy, C2-10 alkynyloxy, SH, C1-10 alkylthio, C1-10 haloalkylthio, aryl(C1.4)alkylthio (where the aryl group is optionally substituted), C3-7 cycloalkylthio (where the cycloalkyl group is optionally substituted with C1-6 alkyl or halogen), tri(C1-4)alkylsilyl(C1-6)alkylthio, arylthio (where the aryl group is optionally substituted), C1-6 alkylsulfonyl, C1-6 haloalkylsulfonyl, C1-6 alkylsulfinyl, C1-6 haloalkylsulfmyl, arylsulfonyl (where the aryl group maybe optionally substituted), tri(Ci_4)alkylsilyl, aryldi(C1-4)alkylsilyl, (C1-4alkyldiarylsilyl, triarylsilyl, C1-10 alkylcarbonyl, HO2C, C1-10 alkoxycarbonyl, aminocarbonyl, C\s alkylammocarbonyl, di(C1-6 alkyl)aminocarbonyl, N-(Ci-3 alkyl)-N-(Ci-3 alkoxy)aminocarbonyl, Q_6 alkylcarbonyloxy, arylcarbonyloxy (where the aryl group is optionally substituted), di(C1-6)alkylaminocarbonyloxy, oximes such as =NOalkyl, =NOhaloalkyl and =NOaryl (itself optionally substituted), aryl (itself optionally substituted), heteroaryl (itself optionally substituted), heterocyclyl (itself optionally substituted with C1-6 alkyl or halogen), aryloxy (where the aryl group is optionally substituted), heteroaryloxy, (where the heteroaryl group is optionally substituted), heterocyclyloxy (where the heterocyclyl group is optionally substituted withC1-6 alkyl or halogen), amino, C1-6 alkylamino, di(C1-6)alkylamino, C1-6 alkylcarbonylamino, N-(C1-6)alkylcarbonyl-N-(C1-6)alkylatnino, C2-6 alkenylcarbonyl, C2-6 alkynylcarbonyl, C3-6 alkenyloxycarbonyl, C3-6 alkynyloxycarbonyl, aryloxycarbonyl (where the aryl group is optionally substituted) and arylcarbonyl (where the aryl group is optionally substituted). Alkenyl and alkynyl moieties can be in the form of straight or branched chains, and the alkenyl moieties, where appropriate, can be of either the (E)- or (Z)-configuration. Examples are vinyl, allyl and propargyl. When present, the optional substituents on alkenyl or alkynyl include those optional substituents given above for an alkyl moiety. In the context of this specification acyl is optionally substituted C\^ alkylcarbonyl (for example acetyl), optionally substituted C2-6 alkenylcarbonyl, optionally substituted C2-6 alkynylcarbonyl, optionally substituted arylcarbonyl (for example benzoyl) or optionally substituted hetero arylcarbonyl Halogen is fluorine, chlorine, bromine or iodine. Haloalkyl groups are alkyl groups which are substituted with one or more of the same or different halogen atoms and are, for example, CF3, CF2C1, CF3CH2 or CHF2CH2. In the context of the present specification the terms "aryl" and "aromatic ring system" refer to ring systems which may be mono-, bi- or tricyclic. Examples of such rings include phenyl, naphthalenyl, anthracenyl, indenyl or phenanthrenyl. A preferred aryl group is phenyl. In addition, the terms "heteroaryl", "heteroaromatic ring" or "heteroaromatic ring system" refer to an aromatic ring system containing at least one heteroatom and consisting either of a single ring or of two or more fused rings. Preferably, single rings will contain up to three and bicyclic systems up to four heteroatoms which will preferably be chosen from nitrogen, oxygen and sulphur. Examples of such groups include furyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, oxazolyl, isoxazoiyl, thiazolyl, isothiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazoIyl, 1,2,5-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,5-thiadiazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, benzofuryl, benzisofuryl, benzothienyl, benzisothienyl, indolyl, isoindolyl, indazolyl, benzothiazolyl, benzisothiazolyl, benzoxazolyl, benzisoxazolyl, benzimidazolyl, 2,1,3-benzoxadiazole quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, naphthyridinyl, benzotriazinyl, purinyl, pteridinyl and indolizinyl. Preferred examples of heteroaromatic radicals include pyridyl, pyrimidyl, triazinyl, thienyl, furyl, oxazolyl, isoxazolyl, 2,1,3-benzoxadiazole and thiazolyl. The terms heterocycle and heterocyclyl refer to a non-aromatic ring containing up to 10 atoms including one or more (preferably one or two) heteroatoms selected from 0, S and N. Examples of such rings include 1,3-dioxolane, tetrahydrofuran and morpholine. When present, the optional substituents on heterocyclyl include C1-6 alkyl andC1-6 haloalkyl as well as those optional substituents given above for an alkyl moiety. Cycloalkyl includes cyclopropyl, cyclopentyl and cyclohexyl. Cycloalkenyl includes cyclopentenyl and cyclohexenyl. When present, the optional substituents on cycloalkyl or cycloalkenyl include C1.3 alkyl as well as those optional substituents given above for an alkyl moiety. Carbocyclic rings include aryl, cycloalkyl and cycloalkenyl groups. When present, the optional substituents on aryl or heteroaryl are selected independently, from halogen, nitro, cyano, NCS-, C1-6 alkyl, C1-6 haloalkyl, C1-6. alkoxy-(Ci^)alkyl, C2-6 alkenyl, C2-6 haloalkenyl, C2-6 alkynyl, C3.7 cycloalkyl (itself optionally substituted with C1-6 alkyl or halogen), C5-7 cycloalkenyl (itself optionally substituted with C1-6 alkyl or halogen), hydroxy, C1-10 alkoxy, C1-10 alkoxy(Ci-io)alkoxy, tri(Ci_4)alkyi-silyl(C1-6)alkoxy, C1-6 alkoxycarbonyl(d-io)alkoxy, C1-10 haloalkoxy, aryl(C]^)alkoxy (where the aryl group is optionally substituted with halogen or C 1.5 alkyl), C3.7 cycloalkyloxy (where the cycloalkyl group is optionally substituted with C1-6 alkyl or halogen), C2-10 alkenyloxy, C2-10 alkynyloxy, SH, C1-10 alkylthio, C1-10 haloalkylthio, aryl(C4_4)alkylthio C3-7 cycloalkylthio (where the cycloalkyl group is optionally substituted with C1-6 alkyl or halogen), the(C1_4)-alkylsilyl(C1-6)alkylthio, arylthio, C1-6 alkylsulfonyl, Ci„6 haloalkylsulfonyl, C1-6 alkylsulfmyl, C^haloalkylsulfinyl, arylsulfonyl, tri(Ci_4)alkylsilyl, aryldi(C1-4)-alkylsilyl? (Ci_4)alkyldiarylsilyl, triarylsilyl, C1-10 alkylcarbonyl, H02C, C1-10 alkoxycarbonyl, aminocarbonyl, C1-6 alkylaminocarbonyl, di(C1-6 alkyl)-aminocarbonyl, N-(CM alkyl)-N-(Ci'-3 alkoxy)aminocarbonyl, Cue alkylcarbonyloxy, arylcarbonyloxy, di(C1-6)alkylamino-carbonyloxy, aryl (itself optionally substituted with C1-6 alkyl or halogen), heteroaryl (itself optionally substituted with Cj.6 alkyl or halogen), heterocyclyl (itself optionally substituted with Cue alkyl or halogen), aryloxy (where the aryl group is optionally substituted with C\.e alkyl or halogen), heteroaryloxy (where the heteroaryl group is optionally substituted with C1-6 alkyl or halogen), heterocyclyloxy (where the heterocyclyl group is optionally substituted with C1-6 alkyl or halogen), amino, C1-6 alkylamino, di(Ci-6)alkylarnino, C1-6 alkylcarbonylamino, N-(C\-6)alkylcarbonyl-N-(C1-6)alkylamino? arylcarbonyl, (where the aryl group is itself optionally substituted with halogen or C]_6 alkyl) or two adjacent positions on an aryl or heteroaryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen or Cue alkyl. Further substituents for aryl or heteroaryl include aryl carbonyl amino (where the aryl group is substituted by C1-6 alkyl or halogen), (Ct-6)alkyloxycarbonylamino (C1-6)alkyloxycarbonyl-lS[-(C1-6)alkylamino, aryloxycarbonylamino (where the aryl group is substituted by Ci-$ alkyl or halogen), aryloxycarbonyl-N-(Q-6)alkylamino, (where the aryl group is substituted by C1-6 alkyl or halogen), arylsulphonylamino (where the aryl group is substituted by C^6 alkyl or halogen), arylsulphonyl-N-(C1-6)alkylamino (where the aryl group is substituted by C\.e alkyl or halogen), aryl-N-(Cj-6)alkylamino (where the aryl group is substituted by C1-6 alkyl or halogen), arylamino (where the aryl group is substituted by C1-6 alkyl or halogen), heteroaryl amino (where the heteroaryl group is substituted by Cue alkyl or halogen), heterocyclylarnino (where the heterocyclyl group is substituted by d_6 alkyl or halogen), aminocarbonylamino, Ci^alkylaminocarbonyl amino, di(C1-6)alkylaminocarbonyl amino, arylaminocarbonyl amino where the aryl group is substituted by C1-6 alkyl or halogen), aryl-N-(C1-6)alkylaminocarbonylamino where the aryl group is substituted by'C1-6 alkyl or halogen), C1-6alkylaminocarbonyl-N-(C1-6)alkyl amino, di(C1-6)alkylaminocarbonyl-N-(C1-6)alkyl amino, arylaminocarbonyl-N-(C1-6)alkyl amino where the aryl group is substituted by Cue alkyl or halogen) and aryl-N-(C1-6)alkylaminocarbonyl-N-(C1-6)alkyl amino where the aryl group is substituted by Cue alkyl or halogen). For substituted phenyl moieties, heterocyclyl and heteroaryl groups it is preferred that one or more substituents are independently selected from halogen, Cue alkyl, C\-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxy, C1-6 haloalkoxy, C\-e alkylthio, C\s haloalkylthio, C1-6 alkylsulfinyl, C1-6 haloalkylsulfinyl, C1-6 alkylsulfonyl, Cue haloalkylsulfonyl, C2-6 alkenyl, C2-6 haloalkenyl, C2-6 alkynyl, C3.7 cycloalkyl, nitro, cyano, CO2H., Q-6 alkylcarbonyl, C1-6 alkoxycarbonyU R25R26N or R27R28NC(0); wherein R25, R26, R27 and R28 are, independently, hydrogen or Q_6 alkyl. Further preferred substituents are aryl and heteroaryl groups. Haloalkenyl groups are alkenyl groups which are substituted with one or more of the same or different halogen atoms. It is to be understood that dialkylamino substituents include those where the dialkyl groups together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from 0, N or S and which is optionally substituted by one or two independently selected (C1-6)alkyl groups. When heterocyclic rings are formed by joining two groups on an N atom, i the resulting rings are suitably pyrrolidine, piperidine, thiomorpholine and morpholine each of which may be substituted by one or two independently selected (C\.e) alkyl groups. Preferably the optional substituents on an alkyl moiety include one or more of halogen, nitro, cyano, HO2C, C1-10 alkoxy (itself optionally substituted by C\.\Q alkoxy), aryl(C]-4)alkoxy, C1-10 alkylthio, C1-10 alkylcarbonyl, C1-10 alkoxycarbonyl, C].e alkylaminocarbonyl, di(Cj-6 alkyl)aminocarbonyl, (C1-6)alkylcarbonyloxy, optionally substituted phenyl, heteroaryl, aryloxy, arylcarbonyloxy, heteroaryloxy, heterocyclyl, heterocyclyloxy, C3-7 cycloalkyl (itself optionally substituted with (Ci_$)alkyl or halogen), C3. 7 cycloalkyloxy, C5-7 cycloalkenyl, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, tri(Ci_4)alkylsilyl, tri(C1-4)alkylsilyl(C1-6)alkoxy, aryldi(Ci^)alkylsilyl, (C1-4)alkyldiarylsilyl and triarylsilyl. Preferably the optional substituents on alkenyl or alkynyl include one or more of halogen, aryl and C3-7 cycloalkyl. A preferred optional substituent for heterocyclyl is C1-6 alkyl. Preferably the optional substituents for cycloalkyl include halogen, cyano and CM alkyl. Preferably the optional substituents for cycloalkenyl include C1-3 alkyl, halogen and cyano. Preferably Y is a single bond, C=0 or S(0)m where m is 0, 1 or 2. More preferably Y is a single bond, C=0 or SO2. Yet more preferably Y is a single bond or C=0. Most preferably Y is C=0. Preferably R1 is hydrogen, C1-6 alky], C1-6 cyanoalkyl, C1-6 haloalkyl, C3.7 cycloalkyl(C1-4)alkyl, C1-6 alkoxy(C1-6)alkyl heteroaryl(C1-6)alkyl (wherein the heteroaryl group may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl C1-6 alkoxy, C1-6 haloalkoxy? C1-6alkylsulfonyl, C1-6 alkylsulfinyl, C1-6 alkylthio, C1-6 alkoxycarbonyl C1-6 alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the heteroaryl system may be cyclised to form a 5,6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), aryl(C1-6)alkyl (wherein the aryl group may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl C1-6 alkoxy, C1-6 haloalkoxy, Cus alkylsulfonyl C1-6 alkylsulfinyl, C1-6 alkylthio, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the aryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), C1-6 alkylcarbonylamino(Q.6)alkyl, aryl (which maybe optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl C1-6 alkylthio, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, arylcarbonyl or two adjacent positions on the aryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), heteroaryl (which may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, C1-6 alkylthio, C1-6 alkoxycarbonyl C1-6 alkylcarbonylamino, arylcarbonyl or two adjacent positions on the heteroaryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), C1-6 alkoxy, C1-6 haloalkoxy, phenoxy (wherein the phenyl group is optionally substituted by halogen, Q_4 alkyl, C1-6 alkoxy, C1-4 haloalkyl, C1-6 haloalkoxy, CN, N02, aryl, heteroaryl amino or dialkylamino), heteroaryloxy (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), heterocyclyloxy (optionally substituted by halo, C1-6 alkyl, C1-6 haloalkyl C1-6 alkoxy or C 1.6 haloalkoxy), cyano, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C5.7 cycloalkenyl, heterocyclyl (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl C1-6 alkoxy or C1-6 haloalkoxy), C1-6 alkylthio, C1-6 haloalkylthio or NR13R14 where R13 and R14 are independently hydrogen, C1-6alkyl, C1-6 haloalkyl, C1-6 alkoxy(Ci. 6)alkyl, phenyl (which may be optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyi, C1-6 haloalkoxy, CN, N02, aryl, heteroaryl, amino, dialkylamino or C1-6 alkoxycarbonyl), phenyl (C1-6)alkyl (wherein the phenyl group may be optionally substituted by halogen, C1-4 alkyl, C1-4 alkoxy, C1-6 haloalkyi, C1-4 haloalkoxy, CN, N02, aryl, heteroaryl, amino, dialkylamino, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl, or two adjacent positions on the phenyl ring may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), heteroaryl (C1-6)alkyl (wherein the heteroaryl group may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyi, C1-6 alkoxy, C\s haloalkoxy, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, C1-6 alkylthio, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the heteroaryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen) or heteroaryl (which may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyi, C1-6 alkoxy or C1-6 haloalkoxy, Ci-4 alkoxycarbonyl C1-6 alkylcarbonylamino, phenyloxycarbonylamino (wherein the phenyl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyi, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), amino, C1-6 alkylamino or phenylamino (wherein the phenyl group is optionally substituted halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyi, C1-4 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino)). More preferably R1 is C1-6 alkyl, C1-6 haloalkyi, C1-6 alkoxy(C1-6)alkyl, heteroaryl(Ci. 3)alkyl (wherein the heteroaryl group may be optionally substituted by halo, nitro, cyano. C1-6 alkyl, C1-6 haloalkyi, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl, or two adjacent positions on the heteroaryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), phenyl(Ci-3)aIkyl (wherein the phenyl group may be optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyi, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino, dialkylamino, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl, or two adjacent positions on the phenyl ring may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), phenyl (which may be optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyi, C1-6 haloalkoxy, CN, N02, aryl, heteroaryl, amino, dialkylamino, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl, or two adjacent positions on the phenyl ring may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), heteroaryl (which may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl, or two adjacent positions on the heteroaryl system maybe cyclised to form a 5. 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), C1-6 alkoxy, C1-6 haloalkoxy, C2~e alkenyl, heterocyclyl (optionally substituted by halo, cyano, C1-6alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), C1-6 alkylthio, C1-6 haloalkylthio or NRnR14 where R13 and R14 are independently hydrogen, C1-6 alkyl or C1-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C2-6 alkylcarbonyl, phenylcarbonyl, (where the phenyl is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), phenyl(Ci_3)alkyl (wherein the phenyl group may be optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino, dialkylamino, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl, or two adjacent positions on the phenyl ring may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen) or heteroaryl(C1-3)alkyl (wherein the heteroaryl group may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylsulfonyl, C1-6 alkylsulfmyl, C1-6 alkylthio, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the heteroaryl system maybe cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen). Even more preferably R1 is C5_6 alkyl, C1-6 haloalkyl, heteroaryl(Ci.3)alkyl (wherein the heteroaryl group may be optionally substituted by halo, cyano, C1-6 alkyl, C1-6 haloalkyl and where the heteroaryl group is a thiazole, pyridine, pyrimidine, pyrazine or pyridazine ring), heteroaryl (optionally substituted by halo, cyano, C1-6 alkyl, C1-6 haloalkyl and where the heteroaryl group is a pyridine, pyrimidine, 2,1,3-benzoxadiazole, pyrazine or pyridazine ring), C1-6 alkoxy, C1-6 alkoxy(C1-6)alkyl, C1-6 alkylamino, C1-6 alkoxy(C1-6)alkylamino or heteroaryl(Ci-3)alkylamino (wherein the heteroaryl group may be optionally substituted by halo, cyano, C1-6 alkyl, C1-6 haloalkyl and where the heteroaryl group is a thiazole, pyridine, pyrimidine, pyrazine or pyridazine ring). Most preferably R1 is pyridyl (optionally substituted by halo, C1-3 alkyl or C1-3 haloalkyl) especially halo-substituted pyridyl. It is preferred that R2 and R3 are independently hydrogen, C1-6 alkyl, C1-6 haloalkyl C1-6 alkoxy or cyano. More preferably R and R are independently hydrogen, halogen, C1-2 alkyl, C1-2 haloalkyl, C1-2 alkoxy, cyano. Even more preferably R2 and R3 are independently hydrogen or C1-6 alkyl. Yet more preferably R and R are independently hydrogen or methyl. Most preferably-R2 and R3 are both hydrogen. Preferably each R4 is independently halogen, cyano, C1_8 alkyl, C1-8 haloalkyl, C1-6 cyanoalkyl, C1-6 alkoxy(C1-6)alkyl, C3-7 cycloalkyl(Cl_6)alkyl, C5-6 cycloalkenyl(C1-6)alkyl, C3-6 alkenyloxy(C1-6)alkyl, C3-6 alkynyloxy(C1-6)alkyl, aryloxy(C1-6)alkyl, C1-6 carboxyalkyl, C1-6 alkylcarbonyl(C1-6)alkyl, C2-6 alkenylcarbonyl(C1-6)alkyl, C2-6 a!kynylcarbonyl(C1-6)-alkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, C3-6 alkenyloxycarbonyl(C1-6)alkyl, C3-6 alkynyloxycarbonyl(C1-6)alkyl, aryloxycarbonyl(C1-6)alkyl, C1-6 alkylthio(C1-6)alkyl, C1-6 alkylsulfinyl(C1-6)alkyI, C1-6 alkylsulfonyl(C1-6)alkyl, aminocarbonyI(CN6)alkyl, C1-6 alkylaminocarbonyl(C1-6)alkyl, di(C1-6)alkylaminocarbonyl(C1-6)alkyl, phenyl(C1-4)alkyl (wherein the phenyl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino), heteroaryl(C1-4)alkyl (wherein the heteroaryl group is optionally substituted by halo, nitro, cyano,C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), heterocycIyl(C1.4)alkyl (wherein the heterocyclyl group is optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), C2-6 alkenyl, aminocarbonyl(C2-6)alkenyl, C1-6 alkylaminocarbonyl(C2-6)alkenyl, di(C1-6)alkyIaminocarbonyl(C2-6)alkenyl, phenyl(C2-4)-alkenyl, (wherein the phenyl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), C2-6 alkynyl, trimethylsilyl(C2-6)alkynyl, aminocarbonyl(C2-6)alkynyl, C1-6 alkylaminocarbonyl(C2.6)alkynyl, di(C1-6)alkylaminocarbonyl(C2-6)alkynyL C1-6 alkoxycarbonyl, C3-7 cycloalkyl, C3-7 haiocycloalkyl, C3-7 cyanocycloalkyl, C1.3 alkyl(C3.7)-cycloalkyl, C1.3 alkyl(C3-7)halocycloalkyl,phenyl (optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl. C1-6 haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino), heteroaryl (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), heterocyclyl (wherein the heterocyclyl group is optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), or 2 adjacent groups R together with the carbon atoms to which they are attached form a 4, 5, 6 or 7 membered carbocylic or heterocyclic ring which may be optionally substituted by halogen, C1-6 alkoxy, C1-6 haloalkoxy, phenoxy (optionally substituted by halo, nitro, cyano, C1-6alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), heteroaryloxy (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), C1-6 alkylthio or Ri9R20N where R19 and R20 are, independently, hydrogen, Q_8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C2_6 haloalkyl, C1-6 alkoxycarbonyl or R19 and R20 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contaiii one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6 alkyl groups; n is 0, 1, 2 or 3. More preferably each R4 is independently halogen, cyano, Q.g alkyl, Ci_g haloalkyl, Ci-s cyanoalkyl, C1-6 alkoxy(C1-6)alkyl, C2-6 alkynyl, trimethylsilyl(C2-6)alkynyl, C1-6 alkoxycarbonyl, C3-7 cycloalkyl, C1-3 alkyl (C3.7) cycloalkyl, phenyl (optionally substituted by halogen, C1-6 alkyl, C1-6'alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino), heterocyclyl (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), C1-6 alkoxy, C1-6 haloalkoxy, phenoxy (optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino), heteroaryloxy (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), di(Cj. 8)alkylamino? or 2 adjacent groups R4 together with the carbon atoms to which they are attached form a 4, 5, 6 or 7 membered carbocylic or heterocyclic ring which may be optionally substituted by halogen; n is 0, 1, 2 or 3. Even more preferably each R4 is independently halogen, cyano, C1-6 alkyl, Ci-s haloalkyl, C1-6 cyanoalkyl, C1-6 alkoxy(C1-6)alkyl, C2-6 alkynyl, heterocyclyl (optionally substituted by C1-6 alkyl), C1-6 alkoxy, C1-6 haloalkoxy, phenoxy (optionally substituted by halo, cyano, C1-6 alkyl or C1-6 haloalkyl), heteroaryloxy (optionally substituted by halo, cyano, C1-6 alkyl or C1-6 haloalkyl), di(Ci-8)alkylamino or 2 adjacent groups R4 together with the carbon atoms to which they are attached form a 4, 5, 6 or 7 membered carbocylic or heterocyclic ring which may be optionally substituted by halogen; n is 0, 1, 2 or 3. Yet more preferably each R is independently fluoro, chloro, bromo, cyano, C1-6 alkyl, C1-4 haloalkyl, C1.4 cyanoalkyl or C1-6 alkoxy(Ci-3)alkyl; n is 0, 1 or 2. Most preferably each R4 is independently fluoro, chloro, bromo, C1-6 alkyl or C1-6 haloalkyl; nis 1 or 2. Preferably R8 is C1-10 alkyl, C1-10 haloalkyl, aryl(C1-6)alkyl (wherein the aryl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), heteroaryl(C1-6)alkyl (wherein the heteroaryl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), arylcarbonyl-(C1-6)alkyl (wherein the aryl group may be optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, Ci_ 4 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino and the alkyl group may be optionally substituted by aryl), C2-8 alkenyl, C2-8 haloalkenyl, aryl(C2-6)-alkenyl (wherein the aryl group is optionally substituted halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino, C1-6 alkoxycarbonyl, or two adjacent substituents can cyclise to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring), heteroaryl(C2-6)-alkenyl (wherein the heteroaryl group is optionally substituted halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino, C1-6 alkoxycarbonyl, or two adjacent substituents can cyclise to form a 5,6 or 7 membered carbocyclic or heterocyclic ring), C2-6 alkynyl, phenyl(C2-6)alkynyl (wherein the phenyl group is optionally substituted by halogen, C1-4 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), C3-7 cycloalkyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyl, C1-6 haloalkylcarbonyl or aryl(C2-6)alkenylcarbonyl (wherein the aryl group may be optionally substituted halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), or -C(R51)(R52)-[CR53=CR 54]z-R55 where z is 1 or 2, R51 and R52 are each independently H, halo or C1-6 alkyl, R53 and R54 are each independently H, halogen, C1-6 alkyl or C1-6 haloalkyl and R ~ is optionally substituted aryl or optionally substituted heteroaryl. More preferably R is phenylC1-4)alkyl (wherein the phenyl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN; NO?, aryl, heteroaryl, amino or dialkylarnino), heteroaryl(C1-6)alkyl (wherein the heteroaryl group is optionally substituted halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxv, CN, NO2, aryl, heteroaryl, amino or dialkylarnino), phenyl(C2-6)alkenyl (wherein the phenyl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, N023 aryl, heteroaryl, amino or dialkylarnino), heteroaryl(C2-6)alkenyl (wherein the heteroaryl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-4 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylarnino) or phenyl(C2-6)alkynyl (wherein the phenyl group is optionally substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylarnino, or-C(R51)(R52)-[CR53=CR54]z-R55 where z is 1 or 2, R51 and R52 are each independently H, halo or C1-2 alkyl, R53 and R54 are each independently H, halogen, C1-6 alkyl or C1-6 haloalkyl and R55 is optionally substituted aryl or optionally substituted heteroaryl. Most preferably R8 is -C(R51)(R52)-[CR53=CR54]z-R55 where z is 1 or 2, preferably 1, are each independently H, halo or C1-2 alkyl, R and R are each independently H, halogen, C1-6 alkyl or C1-6 haloalkyl and R55 is phenyl substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO?, aryl, heteroaryl, amino or dialkylarnino or heteroaryl substituted by halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1. 4 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylarnino. R51andR52 are preferably hydrogen. R53 and R54 are preferably hydrogen or halogen, especially hydrogen. R55 is preferably phenyl substituted with one to three substituents selected from halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylarnino. Preferably each Ra is independently hydrogen, halo, cyano, C1-3 alkyl, hydroxy or two Ra groups together with the carbon atom to which they are attached form a carbonyl group More preferably each Ra is independently hydrogen, fluoro, methyl, hydroxy or two Ra groups together with the carbon atom to which they are attached form a carbonyl group Most preferably each Ra is hydrogen. Preferably p is 1 or 2 and q is 2 or 3 and p+q is 3, 4 or 5. More preferably p is 1 or 2 and q is 2 or 3. Most preferably p is 1 and q is 2 or 3. One group of preferred compounds of formula (I) are those where Yis C(O) and R1 is NR13R14 where R13 and R14 are as defined above Certain compounds of formula (I) are novel and as such form a further aspect of the invention. One group of novel compounds are compounds of formula F (F) wherein Y is CO, R2 and R3 are both hydrogen and R1, R4, R8, Ra, n, p and q are as defined in relation to formula I provided that when n is 0, p is 1, q is 2, Rl is CH3 and all groups Ra are H then R8 is not H, methyl, benzyl or CH2-CH=CH2 and when n is 0, (CRa2)p is CH-phenyl, (CRa2)q is (CH2)2 and R1 is methyl then R8 is not COOCH3. The compounds in Tables I to CCIV below illustrate the compounds of the invention. Table I provides 782 compounds of formula la Table LXXIV provides 782 compounds of formula If wherein each Ra is H, p is 1, q is 3 and the values of R8, R4\-R4b, R4c and R4d are given in Table 1. Table LXXV provides 782 compounds of formula Ig wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table LXXVI provides 782 compounds of formula Ih wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table LXXVII provides 782 compounds of formula Ii wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table LXXVIQ provides 782 compounds of formula Ig wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table LXXXIX provides 782 compounds of formula Ik wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table LXXX provides 782 compounds of formula n wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table LXXXI provides 782 compounds of formula Im wherein each Ra is H, p is 1, q is 5 and the values of K\ R4s, R4fc, R4c and BT are given in Table 1. Table LXXXH provides 782 compounds of formula In wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table LXXXDI provides 782 compounds of formula Io wherein each Ra is H, p is 1, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1. Table LXXXIV provides 782 compounds of formula Ip wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4\ R4c and R4d are given in Table 1, r Table LXXXV provides 782 compounds of formula Iq wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table LXXXVI provides 782 compounds of formula Ir wherein each Ra is H, p is 1, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1. Table LXXXVII provides 782 compounds of formula Is wherein each Ra is H, p is 1, q is 3 and the values of R8, R4*, R4b, R40 and R4d are given in Table 1. Table LXXXVIII provides 782 compounds of formula It wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R40 and R4d are given in Table 1. Table LXXXIX provides 782 compounds of formula Iu wherein each Ra is H, p is 1, q is 3 and the values of R8, R4*, R4b, R4c and R4d are given in Table 1. Table XC provides 782 compounds of formula Iv wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table XCI provides 782 compounds of formula Iw wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table XCII provides 782 compounds of formula Ix wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4\ R4c and R4d are given in Table 1. Table XCIII provides 782 compounds of formula Iy wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table XCIV provides 782 compounds of formula Iz wherein each Ra is H, p is 1, q is 3 and the values of R8> R4a, R4b, R4c and R4d are given in Table 1. Table XCV provides 782 compounds of formula laa wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table XCVI provides 782 compounds of formula lab wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table XCVTI provides 782 compounds of formula lac wherein each Ra is H, p is 1, q is 3 and the values of R83 R4a, R4b> R4c and R4d are given in Table 1. Table XCVUI provides 782 compounds of formula lad wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. ' Table XCIX provides 782 compounds of formula Iae wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table C provides 782 compounds of formula Iaf wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CI provides 782 compounds of formula lag wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CII provides 782 compounds of formula Iah wherein each Ra is H? p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R^ are given in Table 1. Table CIH provides 782 compounds of formula lai wherein each Ra is H, p is 1, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1. Table CIV provides 782 compounds of formula Iaj wherein each Ra is H, p is 1, q is -3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CV provides 782 compounds of formula Iak wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CVI provides 782 compounds of formula Ial wherein each Ra is H, p is 1, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1. Table CVH provides 782 compounds of formula lam wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CVm provides 782 compounds of formula Ian wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CDC provides 782 compounds of formula Iao wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CX provides 782 compounds of formula lap wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXI provides 782 compounds of formula Iaq wherein each Ra is H, p is l% q is . « „ R _ An _ AU _ Ar> AA . -.—=:„ 3 ana me values ot K", K'", K ", K " and K' are given m 1 able 1. Table CXH provides 782 compounds of formula Iar wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXDI provides 782 compounds of fonnula las wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4* are given in Table 1. Table CXIV provides 782 compounds of fonnula lat wherein each Ra is H, p is 1, q is 3 and the values of R8, R4\ R4\ R40 and R4d are given in Table 1. Table CXV provides 782 compounds of formula lau wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXVI provides 782 compounds of fonnula lav wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXVH provides 782 compounds of fonnula law wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R40 and R4d are given in Table 1. Table CXVUI provides 782 compounds of formula lax wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4* are given in Table 1. Table CXDC provides 782 compounds of formula lay wherein each Ra is H, p is 1, q is 3Md the values of R8, R4\ R4b, R4* and R4d are given in Table 1. Table CXX provides 782 compounds of formula Iaz wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXI provides 782 compounds of formula Iba wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXH provides 782 compounds of formula Ibb wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXDI provides 782 compounds of formula Ibc wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXTV provides 782 compounds of formula Ibd wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXV provides 782 compounds of formula Ibe wherein each Ra is H, p is 1, q is 3 and the values of R85 R4\ R4b, R4c and R4d are given in Table 1. Table CXXVI provides 782 compounds of formula Ibf wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXVTI provides 782 compounds of formula Ibg wherein each Ra is H, p is 1 > q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXHI provides 782 compounds of formula Ibh wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXIX provides 782 compounds of formula Ibi wherein each Ra is H, p is 1, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1. Table CXXX provides 782 compounds of formula Ibj wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXX3 provides 782 compounds of formula Ibk wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CVXXH provides 782 compounds of formula Ibl wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXXm provides 782 compounds of formula Ibm wherein each Ra is H, p is 1, q is 3 and the values of R\ R4a, R4b, R4c and R4d are given in Table 1. Table CXXXIV provides 782 compounds of formula Ibn wherein each Ra is H, p is 1, q island the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXXV provides 782 compounds of formula Ibo wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table L Table CXXXVI provides 782 compounds of formula Ibp wherein each Ra is H, p is 1, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1/ Table CXXXVII provides 782 compounds of formula la wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXXVIII provides 782 compounds of formula lb wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXXXIX provides 782 compounds of formula Ic wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXL provides 782 compounds of formula Id wherein each Ra is fi, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table L Table CXLI provides 782 compounds of formula Ie wherein each Ra is H, p is 2, q is 3 and the values of R% R^R4", R4t and R4d are given in Table 1. Table CXLII provides 782 compounds of formula If wherein each Ra is H, p is 2, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1. Table CXLIII provides 782 compounds of formula Ig wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXLTV provides 782 compounds of formula Ih wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R40 and R4d are given in Table 1. Table CXLV provides 782 compounds of formula li wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R40 and R4d are given in Table 1. Table CXLVI provides 782 compounds of formula Ij wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXLVTI provides 782 compounds of formula Be wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXLVTJI provides 782 compounds of formula II wherein each Ra is H, p is 2, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1. Table CXLIX provides 782 compounds of formula Im wherein each Ra is H, p is 2, q is 3 and the values of R8, R4\ R4b? R4c and R4d*regiven in Table 1. Table CL provides 782 compounds of formula In wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLI provides 782 compounds of formula Io wherein each Ra is H, p is 2, q is 3 and the values of R8? R4a, R4b, R4c and R4d are given in Table 1. Table CLII provides 782 compounds of fomiula Ip wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLUI provides 782 compounds of formula Iq wherein each Ra is H? p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLIV provides 782 compounds of formula Ir wherein each Ra is H, p is 2? q is 3 and the values of R8? R4a, R4b, R4c and R4d are given in Table 1. Table CLV provides 782 compounds of formula Is wherein each Ra is H, p is 2, q is 3 and the values of R8, R4as R4b? R4c and R4d are given in Table 1. Table CLVI provides 782 compounds of formula It wherein each Ra is H, p is 2, q is 3 and the values of R8? R4a, R4b, R4c and R4d are given in Table 1. Table CLVH provides 782 compounds of formula lu wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4\ R4c and R4d are given in Table 1. Table CLVDI provides 782 compounds of formula Iv wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLIX provides 782 compounds of formula Iw wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLX provides 782 compounds of formula Ix wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4\ R4c and R4d are given in Table 1. Table CLX1 provides 782 compounds of formula Iy wherein each Ra is H? p is 2, q is 3 and the values of Rs, R4\ R4b, R4c and R4d are given in Table 1. Table CLXII provides 782 compounds of formula Iz wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXHI provides 782 compounds of formula Iaa wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXIV provides 782 compounds of formula lab wherein each Ra is H, p is 2? q is 3 and the value*ef R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXV provides 782 compounds of formula lac wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXVI provides 782 compounds of formula lad wherem each Ra is H, p is 2, q is 3 and the values of Rs, R4a, R4b, R*° and R4d are given in Table 1. Table CLXVE provides 782 compounds of formula lae wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXIII provides 782 compounds of formula Iaf wherem each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXIX provides 782 compounds of formula lag wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXX provides 782 compounds of formula Iah wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXI provides 782 compounds of formula Iai wherein each Ra is H, p is 2, q is 3 and the values of Rs, R4a, R4b, R4c and R40 are given in Table 1. Table CLXXH provides 782 compounds of fonnula laj wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. ' Table CLXXHI provides 782 compounds of formula Iak wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXIV provides 782 compounds of fonnula Ial wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXV provides 782 compounds of formula lam wherein each Ra is H, p is 2, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1. Table CLXXVI provides 782 compounds of formula Ian wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R40 and R4d are given in Table 1. Table CLXXVTI provides 782 compounds of fonnula Iao wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXVUI provides 782 compounds of formula lap wherein each Ra is H, p is 2, q is 3 and the values of R8, R4\ R4b, R4c and R4d are given in Table 1 Table CLXXIX provides 782 compounds of formula Iaq wherein each Ra is H, p is 2, q is 3 and the values of-R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXX provides 782 compounds of formula Iar wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXXI provides 782 compounds of fonnula las wherein each Ra is H? p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXXII provides 782 compounds of fonnula Iat wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXXIH provides 782 compounds of formula Iau wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXXTV provides 782 compounds of formula lav wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXXV provides 782 compounds of fonnula law wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXXVI provides 782 compounds of formula lax wherein each Ra is H, p is 2, q is 3 and. the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CLXXXVII provides 782 compounds of formula lay wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4\ R4c and R4d are given in Table 1. Table CLXXXVm provides 782 compounds of formula Iaz wherein each Ra is H, p is 2, q is 3 and the values of R\ R4a, R4b, R4c and R4d are given in Table 1. Table CLXXXK provides 782 compounds of formula Iba wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXC provides 782 compounds of formula Ibb wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXCI provides 782 compounds of formula Ibc wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R40 and R4d are given in Table 1. Table CXCII provides 782 compounds of formula Ibd wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXCIH provides 782 compounds of fonnula Ibe wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXCIV provides 782 compounds of formula Ibf wherein each Ra is H, p is 2, q is 3 and the values of R8, R^rR4b, R4c and R4d are given in Table 1 . Table CXCV provides 782 compounds of formula Ibg wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXCVI provides 782 compounds of formula Ibh wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4\ R4c and R4d are given in Table 1. Table CXCVII provides 782 compounds of formula Ibi wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CXCVTH provides 782 compounds of formula Ibj wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a5 R4b, R4c and R4d are given in Table 1. Table CXCIX provides 782 compounds of formula Ibk wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1 Table CC provides 782 compounds of formula Ibl wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4d are given in Table 1. Table CCI provides 782 compounds of formula Ibm wherein each Ra is H, p is 2, q is 3 and the values of Rs, R4a, R4b, R4c and R4u' are given in Table 1. Table CCII provides 782 compounds of formula Ibn wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4c and R4"3 are given in Table 1. Table CCiil provides 782 compounds of formula Ibo wherein each Ra is H, p is 2, q is 3 and the values of R8, R4a, R4b, R4* and R4d are given in Table 1. Table CCIV provides 782 compounds of formula Ibp wherein each Ra is H, p is 2, q is 3 and the values of R8, R4*, R4b, R4c and R4d are given in Table 1. Mass spectra data were obtained for selected compounds of Tables I to CCIV using LC1-6S: LC5:254nm - gradient 10% A to 100% B A=H2O+0.01%HCOOH B=CH3CN/CH3OH+0.01%HCOOH positive electrospray 150-1000 m/z. The data are shown in Table 2. Table 2 )q )q Thus a compound of formula 1 may be synthesised from compounds of formula 4 by reaction with an alkylating agent of the formula R8-L, where L is chloride, bromide, iodide or a sulfonate (e.g. mesylate or tosylate) or similar leaving group at a temperature of between ambient temperature and 100°C, typically ambient temperature, in an organic solvent such as acetonitrile, dimethylformamide, dichloromethane, chloroform or 1,2-dichloroethane in the presence of a tertiary amine base such as triethylamine or diisopropylethylamine and optionally catalysed by halide salts such as sodium iodide, potassium iodide or tetrabutylammonium iodide. Alternatively, a compound of formula 4 may be reacted with an aldehyde of the formula RCHO at a temperature between ambient temperature and 100°C in an. organic solvent such as tetralvydrofuran or ethanol or mixtures of solvents in the presence of a reducing agent such as borane-pyridine complex, sodium borohydride, sodium (triacetoxy)borohydride, sodium cyanoborohydride or such like, to produce a compound of formula 1 where R8 is CH2-R. Compounds of formula 1 may also be obtained from compounds of formula 2b by reaction with a suitable electrophiUc species. Compounds of formula 1 where Y is a carbonyl group may be formed by the reaction of compounds of formula 4 with a carboxylic acid derivative of formula R1-C(0)-Z where Z is chloride, hydroxy, alkoxy or acyloxy at a temperature between 0°C and 150°C optionally in an organic solvent such as dichloromethane, chloroform or 1,2-dichloroethane, optionally in the presence of a tertiary amine base such as triethylamine or diisopropylethylamme and optionally in the presence of a coupling agent such as dicyclohexylcarbodiimide. Compounds of formula 1 where Y is a carbonyl group and Rl is an amino substituent of formula R'-NH- may be formed by the reaction of compounds of formula 2b with an isocyanate of formula R'-N=C=0 under similar conditions. Compounds of formula 1 where Y is a group of formula S(0)q may be formed from compounds of formula 2b by treatment with compounds of formula of Rl-S(0)q-Cl under similar conditions. Compounds of formula 1 where Y is a thiocarbonyl group and Rl is an amino substituent of formula R'-NH- may be formed by the reaction of compounds of formula 2b with an isothiocyanate of formula R'-N=:C=S under similar conditions. Alternatively compounds of formula 1 where Y is a thiocarbonyl group and Rl is a carbon substituent maybe formed by treatment of compounds of formula 1 where Y is a carbonyl group and Rl is a carbon substituent with a suitable thionating agent such as Lawesson's reagent. In the above procedures, acid derivatives of the formula R1-C(0)-Z, isocyanates of formula R'-N=C=0, isothiocyanates of formula R'-N=C=S and sulfur electrophiles of formula Rl-S(0)q-Cl are either known compounds or may be formed from known compounds by known methods by a person skilled in the art A compound of formula 4 may be obtained from a compound of formula 3 by reaction with an acid such as tnfluoroacetic acid at ambient temperature in an organic solvent such as dichloromethane, chloroform or 1,2-dichloroethane followed by neutralisation of the reaction mixture with an aqueous solution of ^nonorganic base such as sodium carbonate, sodium bicarbonate or similar compound. A compound of formula 3 may be obtained from a compound of formula 2a by reaction with a suitable electrophilic species, as described above. Compounds of formula 2a and 2b may be synthesised as described in Scheme 2. Thus, compounds of formula 2a may be obtained by reacting compounds of formula 6a with compounds of formula 5 at a temperature of between 0°C and 100°C in an organic solvent such as dichloromethane, chloroform or 1,2-dichloroethane in the presence of an acid such as hydrochloric acid or tnfluoroacetic acid and optionnally a co-solvent such as water, methanol or ethanol. The intermediates formed are subsequently treated with a reducing agent such as sodium borohydride, sodium (triacetoxy)borohydride, sodium cyanoborohydride, triethylsilane or similar at ambient temperature in organic solvent such as ethanol or chloroform or with a nucleophile R3-M (where M is a metallic species; R3-M is for example a Gringnard reagent). Similarly, compounds of formula 2b may be synthesised by reacting compounds of formula 6b with compounds of formula 5 using the conditions described above. Compounds of formula 6a may be obtained from compounds of formula 7a by reaction with a 1-alkoxy substituted phosphonium salt such as methoxymethyl(triphenyl)phosphonium chloride and a base such as potassium ter/-butoxide at a temperature of 0°C to room temperature in tetrahydrofuran- Similarly, compounds of formula 6b maybe synthesised from compounds of formula 7b using the conditions described above. Compounds of formula 7a and 7b are either known compounds or may be formed from known compounds by known methods by a person skilled in the art. I ( A compound of formula 2a, in which p = 1 and q = 3 ma}' be obtained as shown in Scheme 3. Thus, a compound of formula 8 may be reduced to a compound of formula 2b in the presence of a reducing agent such as lithium aluminium, bis(2-methoxyethoxy)aluminium hydride or borane at a temperature of between 0°C and 120°C in an organic solvent such as tetrahydrofuran, diethyl ether, benzene or toluene. A basic procedure is described in Synth. Commun. 1992, 22(5), 729-733. Compounds of formula 8 maybe synthesised by cyclising compounds of formula 9 under radical conditions, such as tributyltin hydride in?ths presence of a radical initiator such as l,r-azobis(cyclohexanecarbonitrile) in an organic solvent such as benzene or toluene at a temperature of between 60C and 120°C, followed by removal of the acetyl protecting group using a base such as sodium hydroxide or potassium hydroxide in an organic solvent such as methanol, ethanol or water at a temperature of between 0°C to 100°C. Compounds of formula 9 may be synthesised by acylating compounds of formula 11 using known methods by the person skilled in the art. Alternatively a compound of formula 8 may be obtained by hydrogenation of a compound of formula 10, which maybe obtained from a compound of formula 11 by cyclising a compound of formula 10 under Heck conditions in the presence of a catalyst such as palladium(II) acetate, optionally a ligand such as triphenylphosphine or/and an additive such as tetrabutylammonium bromide and a base such as triethylamine in an organic solvent such as tetrahydrofuran, acetonitrile or dimethylformamide at a temperature of between 50°C to 140°C. A basic procedure is described in WO 01/05790. Compounds of formula i i may be synthesised by reacting the known compound of formula 12 (Chem. Commun. 1999,1757-1758) with compounds of formula 13 at temperatures of between 0°C to 60°C in an organic solvent such as dichloromethane, benzene or toluene in the presence of a trialkylaluminium reagent such as trimethylaluminium. Compounds of formula 13 are either known compounds or maybe formed from known compounds by known methods by a person skilled in the art. Compounds of formula 14 may be synthesised from compounds of formula 15 by reaction with an alkylating agent of the fonnula R8-L, where L is chloride, bromide, iodide or a sulfonate (e.g. mesylate or tosylate) or similar leaving group, as described above. Compounds of formula 15 may be obtained by radical eyclisation of compounds of formula 16 using the method described in Org. Lett 2000,23, 3599-3601. Compounds of formula 16 may be synthesised by coupling compounds of formula 18 with the known alcohol 19 {J. Org, Chem. 2001, 66, 5545-5551) under Mitsunobu conditions. Compounds of fonnula 18 are either known compounds or may be formed from known compounds such as 20 by known methods by a person skilled in the art. Certain compounds of formula 2a, 2b, 3,4 and 10 are novel and as such form a further aspect of the invention. The compounds of formula (I) can be used to combat and control infestations of insect pests such as Lepidoptera, Diptera, Hemiptera, Thysanoptera, Orthoptera, Dictyoptera, Coleoptera, Siphonaptera, Hymenoptera and Isoptera and also other invertebrate pests, for example, acarine, nematode and mollusc pests. Insects, acarines, nematodes and molluscs are hereinafter collectively referred to as pests. The pests which may be combated and controlled by the use of the invention compounds include those pests associated with agriculture (which term includes the growing of crops for food and fibre products), horticulture and animal husbandry, companion animals, forestry and the storage of products of vegetable origin (such as fruit, grain and timber); those pests associated with the damage of man-made structures and the transmission of diseases of man and animals; and also nuisance pests (such as flies). Examples of pest species which may be controlled by the compounds of formula (I) include: Myziispersicae (aphid), Aphis gossypii (aphid), Aphis fabae (aphid), Lygus spp. (capsids), Dysdercus spp. (capsids), Nilaparvata lugens (planthopper), Nephotettixc incticeps (leafhopper), Nezara spp. (stinkbugs), Euschistus spp. (stinkbugs), Leptocorisa spp. (stinkbugs), Frankliniella occidentalis (thrip), Thrips spp. (thrips), Leptinotarsa decemlineata (Colorado potato beetle), Anthonornus grandis (boll weevil), Aonidiella spp. (scale insects), Trialeurodes spp. (white flies), Bemisia tabaci (white fly), Ostrinia nubilalis (European corn borer), Spodoptera littoralis (cotton leafworm), Heliothis virescens (tobacco budworm), Helicoveipa armigera (cotton bollworm), Helicoverpa zea (cotton bollworm), Sylepta derogata (cotton leaf roller), Pieris brassicae (white butterfly), Plutella xylostella (diamond back moth), Agrotis spp. (cutworms), Chilo suppressalis (rice stem borer), Locusta^ migratoria (locust), Chortiocetes terminifera (locust), Diabrotica spp. (rootworms), Panonychus ulmi (European red mite), Panonychus citri (citrus red mite), Tetranychus urticae (two-spotted spider mite), Tetranychus cinnabarinus (carmine spider mite), Phyllocoptntta oleivora (citrus rust mite), Polyphagotarsonemus latus (broad mite), Brevipalpus spp. (flat mites), Boophilus microplus (cattle tick), Deimacentor variabilis (American dog tick), Ctenocephalides felis (cat flea), Liriomyza spp. (leafininer), Musca domestica (housefly), Aedes aegypti (mosquito), Anopheles spp. (mosquitoes), Culex spp. (mosquitoes), LuciUia spp. (blowflies), Blattella gennanica (cockroach), Periplaneta americana (cockroach), Blatta orientalis (cockroach), termites of the Mastotermitidae (for example Mastotermes spp.), the Kalotermitidae (for example Neotermes spp.), the Rhinotermitidae (for example Copiotennes formosanus, Reticulitermes flavipesy R. speratu, R. virginicus, R. hesperus9 and R. santonensis) and the Termitidae (for example Globitermes sulphureus), Solenopsis geminata (fire ant), Monomorium pharaonis (pharaoh's ant), Damalinia spp. and Linognathus spp. (biting and sucking lice), Meloidogyne spp. (root knot nematodes), Globodera spp. and Heterodera spp. (cyst nematodes), Pratylenchus spp. (lesion nematodes), Rhodopholus spp. (banana burrowing nematodes), Tylenchulus spp.(citrus nematodes), Haemonchus contortus (barber pole worm), Caenorhabditis elegans (vinegar eelworm), Trichostrongylus spp. (gastro intestinal nematodes) and Deroceras reticulatum (slug);- The invention therefore provides a method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I), or a composition containing a compound of formula (I), to a pest, a locus of pest, or to a plant susceptible to attack by a pest, The compounds of formula (I) are preferably used against insects, acarines or nematodes. The term "plant" as used herein includes seedlings, bushes and trees. In order to apply a compound of formula (I) as an insecticide, acaricide, nematicide or molluscicide to a pest, a locus of pest, or to a plant susceptible to attack by a pest, a compound of formula (I) is usually formulated into a composition which includes, in addition to the compound of formula (I), a suitable inert diluent or carrier and, optionally, a surface active agent (SFA). SFAs are chemicals which are able to modify the properties of an interface (for example, liquid/solid, liquid/air or liquid/liquid interfaces) by lowering the interfacial tension and thereby leading to changes in other properties (for example dispersion, emulsification and wetting). It is preferred that all compositions (both solid and liquid formulations) comprise, by weight, 0.0001 to 95%, more preferably 1 to 85%, for example 5 to 60%, of a compound of formula (I). The composition is generally used for the control of pests such that a compound of formula (I) is applied at a rate of from O.lg to 10kg per hectare, preferably from lg to 6kg per hectare, more preferably from lg to 1kg per hectare. When used in a seed dressing, a compound of formula (I) is used at a rate of 0.000 lg to lOg (for example O.OOlg or 0.05g), preferably 0.005g to lOg, more preferably 0.005g to 4g, per kilogram of seed. In another aspect the present invention provides an insecticidal, acaricidal, nematicidal or molluscicidal composition comprising an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I) and a suitable carrier or diluent therefor. The composition is preferably an insecticidal, acaricidal, nematicidal or molluscicidal composition. In a still further aspect the invention provides a method of combating and controlling pests at a locus which comprises treating the pests or the locus of the pests with an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a composition comprising a compound of formula. (I). The compounds of formular(I) are preferably used against insects, acarines or nematodes. The compositions can be chosen from a number of formulation types, including dustable powders (DP), soluble powders (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules (GR) (slow or fast release), soluble concentrates (SL), oil miscible liquids (OL), ultra low volume liquids (UL), emulsifiable concentrates (EC), dispersible concentrates (DC), emulsions (both oil in water (EW) and water in oil (EO)), micro-emulsions (ME), suspension concentrates (SC), aerosols, fogging/smoke formulations, capsule suspensions (CS) and seed treatment formulations. The formulation type chosen in any instance will depend upon the particular purpose envisaged and the physical, chemical and biological properties of the compound of formula (I). Dustable powders (DP) may be prepared by mixing a compound of formula (I) with one or more solid diluents (for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and iriagucsium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid carriers) and mechanically grinding the mixture to a fine powder. Soluble powders (SP) may be prepared by mixing a compound of formula (I) with one or more water-soluble inorganic salts (such as sodium bicarbonate, sodium carbonate or magnesium sulphate) or one or more water-soluble organic solids (such as a polysaccharide) and, optionally, one or more wetting agents, one or more dispersing agents or a mixture of said agents to improve water dispersibility/solubility. The mixture is then ground to a fine powder. Similar compositions may also be granulated to form water soluble granules (SG). Wettable powders (WP) may be prepared by mixing a compound of formula (I) with one or more solid diluents or carriers, one or more wetting agents and, preferably, one or more dispersing agents and, optionally, one or more suspending agents to facilitate the dispersion in liquids. The mixture is then ground to a fine powder. Similar compositions may also be granulated to form water dispersible granules (WG). Granules (GR) may be formed either by granulating a mixture of a compound of formula (I) and one or more powdered solid diluents or carriers, or from pre-formed blank granules by absorbing a compound of formula (I) (or a solution thereof, in a suitable agent) in a porous granular material (such as pumice, attapulgite clays, fuller's earth, kieselguhr, diatomaceous earths or ground corn cobs) or by adsorbing a compound of formula (I) (or a solution thereo^in a suitable agent) on to a hard core material (such as sands, silicates, — mineral carbonates, sulphates or phosphates) and drying if necessary. Agents which are commonly used to aid absorption or adsorption include solvents (such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters) and sticking agents (such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils). One or more other additives may also be included in granules (for example an emulsifying agent, wetting agent or dispersing agent). Dispersible Concentrates (DC) may be prepared by dissolving a compound of formula (I) in water or an organic solvent, such as a ketone, alcohol or glycol ether. These solutions may contain a surface active agent (for example to improve water dilution or prevent crystallisation in a spray tank). Emulsifiable concentrates (EC) or oil-in-water emulsions (EW) may be prepared by dissolving a compound of formula (I) in an organic solvent (optionally containing one or more wetting agents, one or more emulsifying agents or a mixture of said agents). Suitable organic solvents for use in ECs include aromatic hydrocarbons (such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade Mark), ketones (such as cyclohexanone or methylcyclohexanone) and alcohols (such as benzyl alcohol, fiirfuryl alcohol or butanol), N-alkylpyrrolidones (such as N-methylpyrrolidone or N-octylpyrrolidone), dimethyl amides of fatty acids (such as Cs-Cio fatty acid dimethylamide) and chlorinated hydrocarbons. An EC product may spontaneously emulsify on addition to water, to produce an emulsion with sufficient stability to allow spray application through appropriate equipment- Preparation of an EW involves obtaining a compound of formula (I) either as a liquid (if it is not a liquid at room temperature, it may be melted at a reasonable temperature, typically below 70°C) or in solution (by dissolving it in an appropriate solvent) and then emulsifiying the resultant liquid or solution into water containing one or more SFAs, under high shear, to produce an emulsion. Suitable solvents for use in EWs include vegetable oils, chlorinated hydrocarbons (such as chlorobenzenes), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes) and other appropriate organic solvents which have a low solubility in water. Microemulsions (ME) maybe prepared by mixing water with a blend of one or more solvents with one or more SFAs, to produce spontaneously a thermodynamically stable isotropic liquid formulation. A compound of formula (I) is present initially in either the water or the soiv&xt/SFA blend. Suitable solvents for usein MEs include those hereinbefo&s described for use in in ECs or in EWs. An ME may be either an oil-in-water or a water-in-oil system (which system is present may be determined by conductivity measurements) and may be suitable for mixing water-soluble and oil-soluble pesticides in the same formulation. An ME is suitable for dilution into water, either remaining as a microemulsion or forming a conventional oil-in-water emulsion. Suspension concentrates (SC) may comprise aqueous or non-aqueous suspensions of finely divided insoluble solid particles of a compound of formula (I). SCs may be prepared by ball or bead milling the solid compound of formula (I) in a suitable medium, optionally with one or more dispersing agents, to produce a fine particle suspension of the compound. One or more wetting agents may be included in the composition and a suspending agent may be included to reduce the rate at which the particles settle. Alternatively, a compound of formula (I) may be dry milled and added to water, containing agents hereinbefore described, to produce the desired end product. Aerosol formulations comprise a compound of formula (I) and a suitable propeiiant (for example n-butane). A compound of formula (I) may also be dissolved or dispersed in a suitable medium (for example water or a water miscible liquid, such as n-propanol) to provide compositions for use in non-pressurised, hand-actuated spray pumps. A compound of formula (T) may be mixed in the dry state with a pyrotechnic mixture to form a composition suitable for generating, in an enclosed space, a smoke containing the compound. Capsule suspensions (CS) may be prepared in a manner similar to the preparation of EW formulations but with an additional polymerisation stage such that an aqueous dispersion of oil droplets is obtained, in which each oil droplet is encapsulated by a polymeric shell and contains a compound of formula (I) and, optionally, a carrier or diluent therefor. The polymeric shell may be produced by either an interfacial polycondensation reaction or by a coacervation procedure. The compositions may provide for controlled release of the compound of formula (I) and they may be used for seed treatment A compound of formula (I) may also be formulated in a biodegradable polymeric matrix to provide a slow, controlled release of the compound. A composition may include one or more additives to improve the biological performance of the composition (for example by improving wetting, retention or distribution on surfaces; resistance to rain on treated surfaces; or uptake or mobility of a compound of formula (I)). Such additives include surface active agents, spray additives based on oils, for example certain mineral oils or natural plant oils (such as soy bean and rape seed oil), and blends of these with other bio-enhancing adjuvants (ingredients which may aid or modify the action of a compound of formula (I)). A compound of formula (I) may also be formulated for use as a seed treatment, for example as a powder composition, including a powder for dry seed treatment (DS), a water soluble powder (SS) or a water dispersible powder for slurry treatment (WS), or as a liquid composition, including a flowable concentrate (FS), a solution (LS) or a capsule suspension (CS). The preparations of DS, SS, WS, FS and LS compositions are very similar to those of, respectively, DP, SP, WP, SC and DC compositions described above. Compositions for treating seed may include an agent for assisting the adhesion of the composition to the seed (for example a mineral oil or a film-forming barrier). Wetting agents, dispersing agents and emulsifying agents may be surface SFAs of the cationic, anionic, amphoteric or non-ionic type. Suitable SFAs of the cationic type include quaternary ammonium compounds (for example cetyltrimethyl ammonium bromide), imidazolines and amine salts. Suitable anionic SFAs include alkali metals salts of fatty acids, salts of aliphatic monoesters of sulphuric acid (for example sodium lauryl sulphate), salts of sulphonated aromatic compounds (for example sodium dodecylbenzenesulphonate, calcium dodecylbenzenesulphonate, butylnaphthalene sulphonate and mixtures of sodium di-wopropyl- and tri-isopropyl-naphthalene sulphonates), ether sulphates, alcohol ether sulphates (for example sodium laureth-3-sulphate), ether carboxylates (for example sodium laureth-3-caiboxylate), phosphate esters (products from the reaction between one or more fatty alcohols and phosphoric acid (predominately inono-esters) or phosphorus pentoxide (predominately di-esters), for example the reaction between lauryl alcohol and tetraphosphoric acid; additionally these products may be ethoxylated), sulphosuccinamates, paraffin or define sulphonates, taurates and lignosulphonates. Suitable SFAs of the amphoteric type include betaines, propionates and glycinates. Suitable SFAs of the non-ionic type include condensation products of alkylene oxides, such as ethylene oxide, propylene oxide, butylene oxide or mixtures thereof, with fatty alcohols (such as oleyl alcohol or cetyl alcohol) or with alkylphenols (such as octylphenol, nonylphenol or octylcresol); partial esters derived from long chain fatty acids or hexitol anhydrides; condensation products of said partial esters with ethylene oxide; block polymers (comprising ethylene oxide and propylene oxide); alkanolamides; simple esters (for example fatty acid polyethylene glycol esters); amine oxides (for example lauryl dimethyl amine oxide); and lecithins. Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carboxymethylcellulose) and swelling clays (such as bentonite or attapulgite). A compound of formula (I) maybe applied by any of the known means of applying pesticidal compounds. For example, it may be applied, formulated or unformulated, to the pests or to a locus of the pests (such as a habitat of the pests, or a growing plant liable to infestation by the pests) or to any part of the plant, including the foliage, stems, branches or roots, to the seed before it is planted or to other media in which plants are growing or are to be planted (such as soil surrounding the roots, the soil generally, paddy water or hydroponic culture systems), directly or it may be sprayed on, dusted on, applied by dipping, applied as a cream or paste formulation, applied as a vapour or applied through distribution or incorporation of a composition (such as a granular composition or a composition packed in a water-soluble bag) in soil or an aqueous environment. A compound of formula (I) may also be injected into plants or sprayed onto vegetation using electrodynamic spraying techniques or other low volume methods, or applied by land or aerial irrigation systems. Compositions for use as aqueous preparations (aqueous solutions or dispersions) are generally supplied in the form of a concentrate containing a high proportion of the active ingredient, the concentrate being added to water before use. These concentrates, which may include DCs, SCs, ECs, EWs, MEs SGs, SPs, WPs, WGs and CSs, are often required to withstand storage for prolonged periods and, after such storage, to be capable of addition to water to form aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment. Such aqueous preparations may contain varying amounts of a compound of formula (I) (for example 0.0001 to 10%, by weight) depending upon the purpose for which they are to be used. A compound of formula (I) may be used in mixtures with fertilisers (for example nitrogen-potassium- or phosphorus-containing fertilisers). Suitable formulation types ; include granules of fertiliser. The mixtures suitably contain up to 25% by weight of the compound of formula (I). The invention therefore also provides a fertiliser composition comprising a fertiliser and a compound of formula (I). The compositions of this invention may contain other compounds having biological ► activity, for example micronutrients or compounds having fungicidal activity or which possess plant growth regulating, herbicidal, insecticidal, nernaticidal or acaricidal activity. The compound of formula (I) may be the sole active ingredient of the composition or it may be admixed with one or more additional active ingredients such as a pesticide, fungicide, synergist, herbicide or plant growth regulator where appropriate. An additional active ingredient may: provide a composition having a broader spectrum of activity or increased persistence at a locus; synergise the activity or complement the activity (for example by increasing the speed of effect or overcoming repellency) of the compound of formula (I); or help to overcome or prevent the development of resistance to individual components. The particular additional active ingredient will depend upon the intended utility of the composition. Examples of suitable pesticides include the following: a) Pyrethroids, such as permethrin, cypermethrin, fenvalerate, esfenvalerate, deltamethrin, cyhalothrin (in particular lambda-cyhalothrin), bifenthrin, fenpropathrin, cyfluthrin, tefluthrin, fish safe pyrethroids (for example ethofenprox), natural pyrethrin, tetramethrin, s-bioallethrin, fenfluthrin, prallethrin or 5-benzyl-3-furylmethyl-(E)-(lR,3S)-2,2-dimethyl-3-(2-oxothiolan-3-yiidenemethyl)cyclopropanecarboxylate; b) Organophosphates, such as, profenofos, sulprofos, acephate, methyl parathion, azinphos-methyl, demeton-s-methyl, heptenophos, thiometon, fenamiphos, monocrotophos, profenofos, triazophos, methamidophos, dimethoate, phosphamidon, malathion, chlorpyrifos, phosalone, terbufos, fensulfothion, fonofos, phorate, phoxim, pirimiphos-methyl, pirimiphos-ethyl, fenitrothion, fosthiazate or diazinoh; c) Carbamates (including aryl carbamates), such as pirimicarb, triazamate, cloethocarb, carbofuran, furathiocarb, ethiofencarb, aldicarb, thiofurox, carbosulfan, bendiocarb, fenobucarb, propoxur, methomyl or oxamyl; dyjenzoyl ureas, such as difluben triflumuron triflumuron, Jexaflumuron, flufenoxuron or chlorfluazuron; e) Organic tin compounds, such as cyhexatin, fenbutatin oxide or azocyclotin; f) Pyrazoles, such as tebufenpyrad and fenpyroximate; g) Macrolides, such as avermectins or milbemycins, for example abamectin, emamectin benzoate, ivermectin, milbemycin, spinosad or azadirachtin; h) Hormones or pheromones; i) Organochlorine compounds such as endosulfan, benzene hexachloride, DDT, chlordane or dieldrin; j) Amidines, such as chlordimeform or amitraz; k) Fumigant agents, such as chloropicrin, dichloropropane, methyl bromide or metam; 1) Chloronicotinyl compounds such as imidacloprid, thiacloprid, acetamiprid, nitenpyram or thiamethoxam; m) Diacylhydrazines, such as tebufenozide, chromafenozide or methoxyfenozide; n) Diphenyl ethers, such as diofenolan or pyripioxircn; o) Indoxacarb; p) Chlorfenapyr; or q) Pymetrozine. In addition to the major chemical classes of pesticide listed above, other pesticides having particular targets maybe employed in the composition, if appropriate for the intended utility of the composition. For instance, selective insecticides for particular crops, for example stemborer specific insecticides (such as caxtap) or hopper specific insecticides (such as buprofezin) for use in rice may be employed. Alternatively insecticides or acaricides specific for particular insect species/stages may also be included in the compositions (for example acaricidal ovo-larvicides, such as clofentezine, flubenzimine, hexythiazox or tetradifon; acaricidal motilicides, such as dicofol or propargite; acaricides, such as bromopropylate or chlorobenzilate; or growth regulators, such as hydramethylnon, cyromazine, methoprene, chlorfluazuron or diflubenzuron). picoxystrobin (ZA1963), polyoxin D, polyram, probenazole, prochloraz, procymidone, propamocarb, propiconazole, propineb, propionic acid, pyrazophos, pyrifenox, pyrimethanil, pyroquilon, pyroxyfur, pyrrolnitrin, quaternary ammonium compounds, quinomethionate, quiiKxyfeivquintozene, sipconazole (F-l 55). sodium pentachlorophenate, spiroxamiae' streptomycin, sulphur, tebuconazole, tecloftalam, tecnazene, tetraconazole, thiabendazole, thifluzamid, 2-(thiocyanomethylthio)benzothiazole, thiophanate-methyl, thiram, timibenconazole, tolclofos-methyi, tolylfluanid, triadimefon, triadimenol, triazbutil, triazoxide, tricyclazole, tridemorph, trifloxystrobin (CGA279202), triforine, triflumizole, triticonazole, validamycin A, vapam, vinclozolin, zineb and ziram. The compounds of formula (I) maybe mixed with soil, peat or other rooting media for the protection of plants against seed-bome, soil-borne or foliar fungal diseases. Examples of suitable synergists for use in the compositions include piperonyl butoxide, sesamex, safroxan and dodecyl imidazole. Suitable herbicides and plant-growth regulators for inclusion in the compositions will depend upon the intended target and the effect required. An example of a rice selective herbicide which may be included is propanil. An example of a plant growth regulator for use in cotton is PIX™. Some mixtures may comprise active ingredients which have significantly different physical, chemical or biological properties such that they do not easily lend themselves to the same conventional formulation type. In these circumstances other formulation types may be prepared. For example, where one active ingredient is a water insoluble solid and the other a water insoluble liquid, it may nevertheless be possible to disperse each active ingredient in the same continuous aqueous phase by dispersing the solid active ingredient as a suspension (using a preparation analogous to that of an SC) but dispersing the liquid active ingredient as an emulsion (using a preparation analogous to that of an EW). The resultant composition is a suspoemulsion (SE) formulation. The invention is illustrated by the following Examples: (Z)-ylidene]-perhydro-azepine (1.1 g) as an oil (1:1 mixture of isomers). MS (ES+) 292/296 (M+H*). Step C: A mixture of-[(E)-3-(4-Chloro-phenyl)-allyl]-4-[l-methoxy-meth-(Z)-ylidene]-perhydro-azepine (0.6 g) and 4-chlorophenydrazine hydrochloride (0.41 g)in chloroform (20 ml) was treated with trifluoroacetic acid (2.1 ml) and heated at reflux under argon for 18 hours. The reaction mixture was cooled to room temperature, triethylsilane (3.1 ml) was added and the solution refluxed for 2 hours. The reaction mixture was cooled to room temperature, diluted with dichloromethane, neutralised with 30% aqueous ammonium hydroxide, washed with brine, dried (sodium sulphate) and concentrated. The dark residue was purified by silica gel chromatography (cyclohexane:ethyl acetate 1:9) to afford 5-chloro-l'-[^*i37z^-3-(4-chlorophenyl)allyl]spiro[perhydro-azepine-3,3^piperidine] (529 mg). MS (ES+) 387/389 (M+H4). Step D: To a solution of 5-chloro-r-[^a7Z5-3-(4-chlorophenyl)allyl]spiro[perhydro-azepine-3,3'-piperidine] obtained in Step C (250 mg) and triethylamine (0.42 ml) in dichloromethane (10 ml) at 0°C was added 2-chloro-isonicotinoyl chloride (220 mg) and the resulting solution was kept at room temperature for IS hours, diluted with dichloromethane, washed Math diluted aqueous sodium bicarbonate, dried (sodium sulphate) and concentrated. Silica gel chromatography of the residue (cyclohexane:ethyl acetate 3:7) afforded the title compound as a yellow solid (181 mg); tap. 86-90°C; MS (ES+) 526/528/530 (M+H+) Compound CXLI-49 (tap. 166-170°C) was prepared according to procedures analogous to those described in Example 1. Step A: Trimethylaluminium (2M in heptane, 3 ml) was added dropwise to a solution of 2-bromoaniline (860 mg) in dichloromethane (15 ml). After gas evolution ceased, 5,6-dihydro-2H-pyridine-l,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (Chern. Commim. 1999, 1757-1758, l.2.g)dissolved in dichloromethane (10 mF) was added and the resulting mixture was refluxed for 5 hrs. The solution was cooled to 0°C, quenched by careful addition of saturated aqueous sodium bicarbonate (10 ml) and extracted with dichloromethane. The organic layer was washed with brine, dried (Na2SO4) and concentrated in vacuo. The residue was purified by silica gel chromatography (eluent cj'clohexane:ethyl acetate 85:15) to afford 5-(2-bromo-phenylcarbamoyl)-3,6-dihydro-2H-p>Tidine-l-carboxylic acid tert-butyl ester (1.2 g), which was characterised by its mass and NMR spectra. Step B: To a stirred solution of the compound obtained in Step A (3.24 g) in dimethylformamide (60 ml) under argon were added successively triethylamine (3 ml), tetrabutyammonium bromide (3.2 g) and palladium(II) acetate (386 mg) and the resulting mixture was heated under reflux for 5 hours, cooled to room temperature, poured into brine and extracted with ethyl acetate. The organic layer was washed with HC1 IN then water, dried over sodium sulfate and concentrated in vacuo. The residue was purified by silica gel chromatography (eluent cyclohexane:ethyl acetate 8:2) to afford spiro[indolin-2-one-3,3'-(l\2\3\4Metrahydropyridine]-r-carboxylic acid tert-butyl ester (L2 g), which was characterised by its mass and NMR spectra. Step C: Spiro[indolin-2-one-3,3'-piperidine]-r-carboxylic acid tert-butyl ester obtained in Step B (1.12 g) was hydrogenated (1 atm.) in 15 ml tetrahydrofiiran in the presence of 10% Pd/C (0.6 g) to afford after standard work-up spiro[indolin-2-one-3,3'-piperidine]-r-cart>oxylic acid tert-butyl ester (1.06 g), which was characterised by its mass and NMR spectra. MS (ES+) 203 (M-C02-isoprene+H+), 247 (M-isoprene +H+), 303 (M+H+). Step D: A solution of spiro[mdolin-2-one-3,3'-piperidine]-l '-carboxylic acid tert-butyl ester obtained in Step C (650 mg) in toluene (20 ml) at 70°C under argon was treated with sodium bis(2-methoxyethoxy)aluminium hydride (Red-Al, 65% in toluene, 1.3 ml) and the reaction mixture was stirred at 75°C for 2 hours, cooled to room temperature, quenched by addition of ethyl acetate (20 ml), stirred for 15 min. and concentrated in vacuo. The residue was diluted with ethyl acetate, washed with v/ater and brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by silica gel chromatography (eluent cyclohexane:ethyl acetate 7:3) to afford spiro[indoline-3,35-piperidine]-r-carbox}'lic acid tert-butyl ester (331 mg) as a colorless oil, which was characterised by its mass and NMR spectra. MS (ES+) 233 (M-isoprene +H4), 289 (M+H*). -- Step E: To a sfclutioirof^iro[indoline-3,3'-p^ acid tert-butyl ester obtained in Step D (140 mg) and triethylamine (0.28 rnl) in dichloromethane (5 ml) at 0°C was added 2-chloroisonicotinoyl chloride (176 mg). After stirring at room temperature for 1 hour, the solution was diluted with dichloromethane, washed with water, dried (sodium sulfate and concentrated in vacuo. The residue was disoolved in dichloromethane (12.5 ml) and trifluoroacetic acid (L25 ml) was added. The reaction mixture was stirred at room temperature for 1 hour, diluted with dichloromethane, neutralised with saturated sodium bicarbonate, dried (sodium sulfate) and concentrated in vacuo. The residue was dissolved in acetonitrile (10 ml); diisopropylethylamine (0.13 ml) and 4-chlorocinnamyl chloride (93 mg) were added and the resulting mixture was stirred at room temperature for 12 hours then the solvent was evaporated in vacuo. The residue was purified by silica gel chromatography (eluent cyclohexane:ethyl acetate 6:4) to afford the title product (143 mg), which was characterised by its mass and NMR spectra. MS (ES+) 478/480 (M+H+). Compound LXXI-26 was prepared according to procedures analogous to those described in Example 2. the resulting suspension was stirred at ~10°C for 15 min then 4-chloro-2-iodo-N-methanesulfonyl-aniline (3,.l g) was added as a solid followed by 2-methylene-butane-l34-diol (0.95 g) dissolved in a minimum of tetrahydrofuran. The reaction mixture was stirred at „ room temperature for 6 hours, the solvent was evaporated in vacuo and The residue was purified by silica gel chromatography (eluent ethyl acetate: cyclohexane 4:6) to afford N-(4-Chloro-2-iodo-phenyl)-N-(4-hydroxy-2-methylene-butyl)-methanesulfonamide (3.5 g) contaminated with triphenylphosphine oxide. Step B: To a stirred solution of N-(4-Chloro-2-iodo-phenyl)-N-(4-hydroxy-2-methylene-butyl)-methanesulfonamide obtained in Step A and triphenylphosphine (3.5 g) in dimethylacetamide (80 ml) at -10°C under argon was added carbon tetrabromide (4.5 g). The reaction mixture was stirred at -10°C for 45 min (a precipitate formed). Sodium azide (2 g) was added in one portion and the reaction mixture was stirred at 45 °C for 1 hour, cooled to room temperature, poured into water, extracted with ethyl acetate; the organic layer was washed with brine, dried (Na2S04) and concentrated in vacuo. The residue was purified by silica gel chromatography (eluent cyclohexane:ethyl acetate 7:3) to afford N-(4-Chloro-2-iodo-phenyl)-N-(4-azido-2-methylene-butyl)-methanesulfonamide (1.96 g). *HNMR (CDC13,400 MHz) 2.50 (m, 2H), 3.48 (m, 2H), 4.19 (d, J = 12.0 Hz, 1H), 4.40 (d, J = 12.0 Hz, 1H), 4.90 (s, 1H), 5.01 (s, 1H), 7.29 (d, J = 8.5 Hz, 1H), 7.36 (dd, J = 0.9 H, 8.5 Hz, 1H), 7.92 (d; J = 0.9 Hz, 1H). Step C: A degassed solution of N-(4-Chloro-2-iodo-phenyl)-N-(4-azido-2-methylene-butyl)-methanesulfonamide (1.38 g) in benzene (200 ml) was heated to reflux under argon. Tris(trimethylsilyl)silane (1.32 ml) was added dropwise followed by l,l'-azobis(cyclohexane carbonitrile) (110 mg). The reaction mixture was stirred at reflux for 20 hours then concentrated in vacuo. The residue was dissolved in ethyl acetate (60 ml), extracted with HCl 2N (3x60 ml). The aqueous layer was basified with 2N sodium hydroxide (250 ml) then extracted with ethyl acetate (3x150 ml). The combined organic layers were dried over sodium sulfate and the solvent evaporated in vacuo to afford l-methanesulfonyl-5-chloro-spiro[indoline-3,3'-pyrrolidine] (766 mg) which was used as such for the next step. Step D: To a solution of l-methanesulfonyl-5-chloro-spiro[indoline-3,3'-pytrolidine] (725 mg) in acetonitrile (40 ml) were added diisopropylethylamine (0.66 ml) and 4-chloro-cinnamyl chloride (467 mg). The resulting solution was stirred at room temperature for 12 hours, diluted with ethyl acetate, washed with water, brine, dried (Na2S04) and concentrated growth regulation 3 days after treatment (DAT). The following compounds gave at least 80% control of Spodoptera littoralis: HI-49 and CXXXIX-49. Heliothis virescens ( Tobacco budworni): Eggs.-(0-24 h old) were placed in 24-well rnicrotiter plate on artificial diet and Treated with test solutions at an application rate of 200 ppm by pipetting. After an incubation period of 4 days, samples were checked for egg mortality, larval mortality, and growth regulation. The following compounds gave at least 80% control of Heliothis virescen: ffl-3, ffi-49, CXXXIX-49 and CXLI-49. Plutella xylostella (Diamond back moth): 24-well rnicrotiter plate (MTP) with artificial diet was treated with test solutions at an application rate of 18.2 ppm by pipetting. After drying, the MTP's were infested with larvae (L2)(10-15 per well). After an incubation period of 5 days, samples were checked for larval mortality, antifeedant and growth regulation. The following compounds gave at least 80% control of Plutella xylostella: HI-49 and CXXXIX-49. Aedes aegy>pti (Yellow fever mosquito): 10-15 Aedes larvae (L2) together with a nutrition mixture are placed in 96-weil rnicrotiter plates. Test solutions at an application rate of 2ppm are pipetted into the wells. 2 days later, insects were checked for mortality and growth inhibition. The following compounds gave at least 80% control of Aedes aegyptt HI-49 and CXLI-49. CLAIMS 1. A method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to 'attack by a pest an insecticidally acaricrdally, nematicidally or molluscicidally -effective amount of a compound of formula L wherein Y is a single bond, C=0, C=S or S(0)m where m is 0, 1 or 2; Rl is hydrogen, optionally substituted alkyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, aminocarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted aryl, optionally substituted heteroaryl. ontionallv substituted alkoxy. ontionallv substituted arvloxv. optionally substituted heteroaryloxy, optionally substituted heterocyclyloxy, cyano, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, formyl, optionally substituted heterocyclyl, optionally substituted alkylthio, NO or NR13R14 where R13 and R14 are independently hydrogen, COR15, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl or R13 and R14 together with the N atom to which they are attached form a group -N=C(R16)- . NR17R18; R15 is H, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted aryloxy optionally substituted heteroaryl, optionally substituted heteroaryloxy or NR19R20; R17,R18 and R18 are each independently H or lower alkyl; R19 and R20 are independently optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R2and R3 are independently hydrogen, halogen, cyano, optionally substituted alkyl, optionally substituted alkoxy or optionally substituted aryl; each R4 is independently halogen, nitro, cyano, optionally substituted C1-8 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optiotfallysubstituted dialkylaminocarbonyl, optionally substituted C3-7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryk optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio orR K N where R and R are, independently, hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3.6 alkynyl, C3-7 cyc!oalkyl(Ci_ 4)alkyl, C2-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl or R and R together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6 alkyl groups, or 2 adjacent groups R4 together with the carbon atoms to which they are attached form a 4, 5, 6,or 7 membered carbocyclic or heterocyclic ring which may be optionally substituted by halogen; n is 0, 1, 2, 3 or 4; each Ra is independently hydrogen, halogen, hydroxy, cyano, optionally substituted Ci-s alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted C3-7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio, optionally substituted arylthio or R" R N where R and R23 are, independently, hydrogen, C1-8% alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloaIkyl(C1_4)alkyI, C2-6 haloalkyl, C1-6 alkoxy(C1-6)aIkyl, C1-6 alkoxycarbonyl or R and R" together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6 alkyl groups, or two Ra groups on the same carbon atom are =0 or two adjacent Ra groups are a bond, or two Ra groups together with the carbon to which they are bound form a three- to seven-membered ring, that may be saturated or unsaturated, and that may contain one or two hetero atoms selected from the group consisting of N, O and S, and which may be optionally substituted by one or two C1-6 alkyl groups; or two Ra groups together form a group -CH2-, -CH=CH- or -CH2CH2; p is 0, I,2,3,4, 5 or 6; cp is 0,1,2, 3,4,-5 or 6;-provided that when p is 2 then q is— not 2; p+q is 1, 2, 3, 4, 5 or 6; R8 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl or optionally substituted alkenylcarbonyl; or salts or N-oxides thereof. A method according to claim 1 wherein Y is a single bond or C=0. A method according to claim 1 or claim 2 wherein R and R are each independently hydrogen, C1-6 alkyl, C\.$ haloalkyl, Cue alkoxy or cyano. A method according to any preceeding claim wherein R1 is hydrogen, C1-6 alkyl, Q_6 cyanoalkyl, C1-6 haloalkyl, C3.7 cycloalkyl(C1-6)alkyl, C1-6 alkoxy(C1-6)alkyl, heteroaryl(C1-6)alkyl (wherein the heteroaryl group may be optionally substituted by halo, nitro, cyano, C1.6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1.6 haloalkoxy, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, C1-6 alkylthio, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the heteroaryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), aiyl(C)^)alkyl (wherein the aryl group may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, Ci_ 6 haloalkoxy, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, C1-6 alkylthio, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the aryl system may be cyclised to form a 5,6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), C1-6 alkylcarbonylamino(C1-6)alkyl, aryl (which may be optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylsulfonyi, C1-6alkylsulfinyl, C1-6alkylthio, C1-6 alkoxycarbonyl, C1-6alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the aryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself . optionally substituted with halogen), heteroarylwhich may be optionally substituted by halo, nitro, cyano, C1-6alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6alkylsulfonyi, C1-6alkylsulfinyl, C1-6 alkylthio, C1-6alkoxycarbonyl, C1-6alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the heteroaryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), C1-6 alkoxy, C1-6haloalkoxy, phenoxy (wherein the phenyl group is optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino), heteroaryloxy (optionally substituted by halo, nitro, cyano, C1-6alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6haloalkoxy), heterocyclyloxy (optionally substituted by halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6haloalkoxy), cyano, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C5-7 cycloalkenyl, heterocyclyl (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C\-6 haloalkoxy), Cu6 alkylthio, C1-6haloalkylthio or NR13R14 where R13 and R14 are independently hydrogen, C1-6 alkyl, C1-6haloalkyl, C1-6 alkoxy(C1-6)alkyl, phenyl (which maybe optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02, aryl, heteroaryl, amino, dialkylamino or C1-4 alkoxycarbonyl), phenyl (C1-6)alkyl (wherein the phenyl group may be optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02, aryl, heteroaryl, amino, dialkylamino, C1-6 alkylsulfonyi, C1-6alkoxycarbonyl, or two adjacent positions on the phenyl ring may be cyclised to form a 5,6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen), heteroaryl (C1-6)alkyl (wherein the heteroaryl group may be optionally substituted by halo, nitro, cyano, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C1-6haloalkoxy. C1-6alkylsulfonyi, C1-6alkylsulfinyl, C1-6alkylthio, C1-6alkoxycarbonyl, C1-6alkylcarbonylamino, arylcarbonyl, or two adjacent positions on the heteroaryl system may be cyclised to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring, itself optionally substituted with halogen) or heteroaryl (which may be optionally substituted by halo, nitro, cyano, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy or C1-6haloalkoxy, C1-6 alkoxycarbonyl C1-6 alkylcarbonylamino, phenyloxycarbonylamino (wherein the phenyl group is optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), amino, C1-6 alkylaminooEhenylamino (wherein the phenyl group is optionally substituted halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino)). 5. A method according to any preceeding claim wherein each R is independently halogen, cyano, Ci_8 alkyl, Ci.g haloalkyl C\^ cyanoalkyl, C1-6 alkoxy(C1-6)alkyl, C3-7 cycloalkyl(C1-6)alkyl, C5-6 cycloaIkenyl(C1-6)alkyl, C3.6 alkenyloxy(C1-6)alkyl, C3-6 alkynyloxy(C1-6)alkyl, aryloxy(C1-6)alkyl, C1-6 carboxyalkyl, C1-6 alkylcarbonyl(Ci. 6>alkyl, C2-6 alkenylcarbonyl(C1-6)alkyl, C2-6 alkynylcarbonyl(C1-6)-alkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, C3-6 alkenyloxycarbonyl(C1-6)alkyl, C3.6 alkynyloxycarbonyl(C]-6)alkyl, aryloxycarbonyl(C]-6)alkyl, C\.e alkylthio(C1-6)alkyl, C1-6 alkylsulfinyl(C1-6)alkyl, C\s alkylsulfonyl(C1-6)alkyl, aminocarbonyl(Ci.6)alkyl, C1-6alkylaminocarbonyl(C1-6)alkyl, di(C1-6)alkylaminocarbonyl(C1-6)alkyl, phenyl(C1-6)alkyl (wherein the phenyl group is optionally substituted by halogen, C1-6aikyi, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), heteroaryl(Ci_4)alkyl (wherein the heteroaryl group is optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), heterocyclyl(C1-6)alkyl (wherein the heterocyclyl group is optionally substituted by halo, nitro, cyano, C1-6 alkyl, C\.e haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), C2-6 alkenyl, aminocarbonyl(C2-6)alkenyl, C1-6alkylaminocarbonyl(C2-6)alkenyl, di(C1-6)alkylaminocaibonyl(C2-6)alkenyl, phenyl(C2-4)-alkenyl, (wherein the phenyl group is optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), C2-6 alkynyl, trimethylsilyl(C2^)alkynyl, aminocarbonyl(C2-6)alkynyl, C\-e alk>4aminocaibonyl(C2^)alkynyl, di(C1-6)alkylaininocarbonyl(C2-6)alkynyl, C1.6 alkoxycarbonyl, C3-7 cycloalkyl, C3-7 halocycloalkyl, C3.7 cyanocycloalkyl, C1.3 alkyl(C3-7)-cycloalkyl, C1.3 aIkyl(C3-7)halocycloalkyl,phenyl (optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino), heteroaryl (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6haloalkyl, C1-6alkoxy or C1-6haloalkoxy), heterocyclyl (wherein the heterocyclyl group is optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), or 2 adjacent groups R4 together with the carbonjitoms4oAvhich they are attached form a 4, 5, 6 or 7 membered carbocylic or heterocyclic ring which may be optionally substituted by halogen, C1-6alkoxy, C1-6haloalkoxy, phenoxy (optionally substituted by halo, nitro, cyano, C1-6alkyl, C1-6 haloalkyl, C1-6alkoxy or C1-6haloalkoxy), heteroaryloxy (optionally substituted by halo, nitro, cyano, C1-6alkyl, C1-6haloalkyl, C1-6 alkoxy or C1-6haloalkoxy), C1-6alkylthio or Ri9R20N where R19 and R20 are, independently, hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C2-6 haloalkyl, C1-6alkoxycarbonyl or R19 and R20 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6alkyl groups; and n is 0, 1, 2 or 3. 6. A method according to any proceeding claim wherein R is C1-6O alkyl, C1-6O haloalkyl, aryl(C1-6)alkyl (wherein the aryl group is optionally substituted by halogen, C1-4 alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino), heteroaryl(C1-6)alkyl (wherein the heteroaryl group is optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino), arylcarbonyl-(Ci-6)alkyl (wherein the aryl group maybe optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, NO2, aryl, heteroaryl, amino or dialkylamino and the alkyl group may be optionally substituted by aryl), C2-8 alkenyl, C2-8 haloalkenyl, aryi(C2-6-alkenyl (wherein the aryl group is optionally substituted halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino, C1-6alkoxycarbonyl, or two adjacent substituents can cyclise to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring), heteroaryl(C2-6)-alkenyl (wherein the heteroaryl group is optionally substituted halogen. C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino, C1-6alkoxycarbonyl, or two adjacent substituents can cyclise to form a 5, 6 or 7 membered carbocyclic or heterocyclic ring), C2-6 alkynyl, phenyl(C2-6)alkynyl (wherein the phenyl group is optionally substituted by halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02, aryl, heteroaryl, amino or dialkylamino), C3.7 cyclo alkyl, C1-6 alkoxycarbonyl, C1_6 alkylcarbonyl, C1-6 haloalky fearbonyl or aryl(C2-6)alkenylcarbonyL(wherein the aryl group may be optionally substituted halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, N02? aryl, heteroaryl, amino or dialkylamino), or -C(R5I)(R52)-[CR53=CR jz-R55 where z is 1 or 2, R51 and R52 are each independently H, halo or C1-2 alkyl, R and R~ are each independently H, halogen, C1-6alkyl or C1-6haloalkyl and R55 is optionally substituted aryl or optionally substituted heteroaryl. 7. A method according to any preceeding claim wherein each Ra is hydrogen. 8. A method according to any preceeding claim wherein p is 1 or 2 and q is 2 or 3. 9. A compound of formula F wherein Y is CO, R2 and R3 are both hydrogen, Rl is hydrogen, optionally substituted alkyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, aminocarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocyclyloxy, cyano, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, fonnyi, optionally substituted heterocyclyl, optionally substituted alkylthio, NO or NR13R14 where R13 and R14 are independently hydrogen,. COR15, optionally substituted alkyl, optionally substituted aryl, optionally substituted 1 ^ \ A heteroaryl, optionally substituted heterocyclyl or R " and R together with the N atom to which they are attached form a group -N=C(R16)-NRl7R18; R15 is H, ' optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted arylpxy optionally substituted heteroaryl, optionally substituted heteroaryloxy or NR R" ; R , R and R are each independently H or lower alkyl; R19 and R20 are independently optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; each R4 is independently halogen, nitro, cyano, optionally substituted C\.% alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted C3-7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio or R20R21N where R20 and R21 are, independently, hydrogen, C1.8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl(Ci. 4)alkyl, C2.6 haloalkyl, C\* alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl or R20 and R21 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C\^ alkyl groups, or 2 adjacent groups R4 together with the carbon atoms to which they are attached form a 4, 5, 6,or 7 membered carbocyclic or heterocyclic ring which may be optionally substituted by halogen; n is 0,1,2,3 or 4; each Ra is independently hydrogen, halogen, hydroxy, cyano, optionally substituted C1-8 alkyl, optionally substituted C2.6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted C3-7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio, optionally substituted arylthio or R^R^N where R22 and R23 are, independently, hydrogen, Ci-s alkyl, C3.7 cycloalkyl, C3.6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl(C1-6)alkyl, C2.6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl or R22 and R23 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from ©™N-or S and which may be optionally substituted by one or two C1.6 alkyl groups, or two Ra groups on the same carbon atom are =0 or two adjacent Ra groups are a bond, or two Ra groups together with the carbon to which they are bound form a three- to seven-membered ring, that may be saturated or unsaturated, and that may contain one or two hetero atoms selected from the group consisting of N, O and S, and which may be optionally substituted by one or two C1-6 alkyl groups; or two Ra groups together form a group -CH2-, -CH=CH- or -CH2CH2; p is 0, 1, 2, 3, 4, 5 or 6; q is 0, 1, 2, 3, 4, 5 or 6; provided that when p is 2 then q is not 2; p+qis 1, 2, 3, 4, 5 or 6; R is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl or optionally substituted alkenylcarbonyl; or salts or N-oxides thereof provided that when n is 0, p is 1, q is 2, Rl is CH3 and all groups Ra are H then R8 is not H, methyl, benzyl or CH2-CH=CH2 and when n is 0, (CRa2)p is CH-phenyl, (CRa2)q is (CH2)2 and R1 is methyl then R8 is not COOCH3. 10. A compound of formula II wherein Y,n, p, q, R , R , R , R and Ra are as defined in claim 9 and R is hydrogen or tert-butoxycarbonyl. 11. An insecticidal acaricidal and nematicidal composition comprising an insecticidally, acaricidally or nematicidally effective amount of a compound of formula I as defined in claim

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