Indian Patents. 259680:ANTI-DANDRUFF HAIR CONDITIONING COMPOSITIONS

Title of Invention	ANTI-DANDRUFF HAIR CONDITIONING COMPOSITIONS
Abstract	A hair conditioning composition comprising a cationic surfactant, triglyceride oil, and an anti dandruff agent.

Full Text	FORM - 2 THE PATENTS ACT, 1970 (39 of 1970) & The Patents Rules, 2003 COMPLETE SPECIFICATION (See Section 10 and Rule 13) ANTI-DANDRUFF HAIR CONDITIONING COMPOSITIONS HINDUSTAN UNILEVER LIMITED, a company incorporated under the Indian Companies Act, 1913 and having its registered office at 165/166, Backbay Reclamation, Mumbai -400 020, Maharashtra, India The following specification particularly describes the invention and the manner in which it is to be performed WO 2008/003677 PCT/EP2OO7/056643 HAIR CONDITIONING COMPOSITIONS FIELD OF THE INVENTION 5 The present invention relates to hair conditioning compositions which comprise an antidanclruf f agent. BACKGROUND TO THE INVENTION AND PRIOR ART 10 There is a need for effective compositions for the treatment of dandruff. One way of solving this problem is to prepare compositions that give better deposition of an antidandruff agent onto the hair and/or the scalp. 15 The present invention is based on the Surprising finding that conditioning formulations can be formulated that give excellent deposition of antidandruff Agents. 20 SUMMARY OF THE INVENTION The invention provides a hair conditioning composition comprising a hair conditioning composition comprising a cationic surfactant, triglyceride oil ^nd an anti dandruff 2 5 agent. The invention also provides a method of mitigating dandruff by applying to the scalp to the scalp a composition as described above. 30 WO 2008/003677 PCT/EP2007/056643 DETAILED DESCRIPTION OF THE INVENTION Antidandruff Agent 5 Compositions of the invention comprise an anti-dandruff agent. Preferred antidandruff agents include zinc pyrithione, octopirox, climbazole and ketoconazole. 10 Preferably, the anti-dandruff agent is in solution in the composition. The anti-dandruff agent is therefore preferably soluble in the composition of the invention at 25 degrees C. Most preferably, the anti-dandruff agent is climbazole (1-imidazolyl-l-(4-chlorophenoxy)-3,3- 15 dimethylbutan-2-one). The anti-dandruff agent may be a single anti-dandruff compound or a mixture of different anti-dandruff compounds. 20 Preferably, the anti-dandruff agent is present in the composition in an amount of from 0.1 to 5% by weight, more preferably from 0.1 to 2% by weight. Triglyceride Oil 25 The hair conditioning composition of the invention comprises a triglyceride oil, preferred oils include avocado oil/ olive oil, corn oil, rape seed oil, sesame oil, wheat germ oil, castor oil, linseed oil, sunflower oil, cottonseed oil, 30 soybean oil, peanut oil, and mixtures thereof. Particularly preferred is sunflower oil. WO 2008/003677 PCT/EP2007/056643 The level of triglyceride oil is preferably from 0.1 to 10 wt% of the total composition, more preferably from 0.5 to 5 wt%, most preferably from 1 to 3 wt%. 5 The weight ratio of antidandruff agent to sunflower oil is preferably from 1:4 to 4:1, more preferably from 1:3 to 2:1, most preferably from 1:1 to 1:3. Cationic Surfactant 10 Compositions according to the invention comprise one or more cationic surfactants which are cosmetically acceptable and suitable for topical application to the hair. 15 Suitable cationic surfactants for use in compositions of the invention contain amino or quaternary ammonium hydrophilic moieties which are positively charged when dissolved in the composition. 20 Suitable quaternary ammonium cationic surfactants correspond to the following general formula (I): [NCR1) (R2) (R3) (R4)]+ (X)" (I) 25 in which R1, R2, R3, and R4 are each independently selected from (a) an aliphatic group of from 1 to 22 carbon atoms, or (b) an aromatic, alkoxy, polyoxyalkylene, alkylamido, hydroxyalkyl, aryl or alkylaryl group having up to 22 carbon atoms; and X is a salt-forming anion such as those selected 30 from halogen, (e.g. chloride, bromide), acetate, citrate, WO 2008/003677 PCT/EP2007/056643 lactate, glycolate, phosphate nitrate, sulphate, and alkylsulphate radicals. The aliphatic groups can contain, in addition to carbon and 5 hydrogen atoms, ether linkages, and other groups such as amino groups. The longer chain aliphatic groups, e.g., those of about 12 carbons, or higher, can be saturated or unsaturated. 10 In a suitable class of cationic surfactant of general formula (I), R1 and R2 are each independently selected from Cis to C22 hydrocarbyl chains comprising at least one ester linkage in both R1 and R2, and R3 and R4 are each independently selected from CH3 and CH2CH2OH. 15 In another suitable class of cationic surfactant of general formula (I), R1 and R2 are each independently selected from C16 to C22 saturated or unsaturated, preferably saturated, chains, and R3 and R4 are each independently selected from 20 CH3 and CH2CH2OH, preferably CH3. In a preferred class of cationic surfactant of general formula (I), R1 is a Ci6 to C22 alkyl chain and R2, R3 and R4 are each independently selected from CH3 and CH2CH2OH, 25 preferably CH3. Specific examples of suitable quaternary ammonium cationic surfactants of general formula (1} are cetyltrimethylammonium chloride, behenyltrimethylammonium chloride (BTAC), 30 cetylpyridinium chloride, tetramethylammonium chloride, tetraethylammonium chloride, octyltrimethylammonium chloride, WO 2008/003677 PCTYEP2007/056643 dodecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, octyldimethylbenzylammonium chloride, decyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, 5 didodecyldimethylammonium chloride, dioctadecyldimethylammonium chloride, tallowtrimethylammonium chloride, cocotrimethylammonium chloride, dipalmitoylethyldimethylammonium chloride, PEG-2 oleylammonium chloride and salts of these, where the chloride 10 is replaced by halogen, (e.g., bromide), acetate, citrate, lactate, glycolate, phosphate nitrate, sulphate, or alkylsulphate. Particularly preferred is behenyltrimethylammonium chloride (BTAC) 15 Mixtures of any of the foregoing materials may also be suitable. Salts of primary, secondary, and tertiary fatty amines are also suitable cationic surfactants for Use in the invention. 20 The alkyl groups of such amines preferably have from about 12 to about 22 carbon atoms, and can be substituted or unsubstituted. Th^se amines are typically used in combination with an acid to provide the cationic species. 25 A preferred class 0f amine corresponds to the following general formula HZ); R1 - C(O) - N(H)- fc2 - N(R3) (R4) (II) 30 WO 2008/003677 PCT/EP2007/056643 in which R1 is a fatty acid chain containing from 12 to 22 carbon atoms, R2 is an alkvlene group containing from one to four carbon atoms, and R3 and R4 are, independently, an alkyl group having from one to four carbon atoms. 5 Specific examples of suitable materials of general formula (II) are stearamidopropyldimethylamine, s tear ami dopropyldiethylamine, s tear amidoe'thyldie thy lamine, stearamidoethyldimethylamine, palmitamidopropyldimethylamine, 0 palmitamidopropyldiethylamine, palmitamidoethyldiethylamine, palmitamidoethyldimethylamine, behenamidopropyldimethylamine, behenamidopropyldiethylamine, behenamidoethyldiethylamine, behenamidoethyldimethylamine, arachidamidopropyldimethylamine, 5 arachidamidopropyldiethylamine, arachidamidoethyldiethylamine, arachidamidoethyldimethylamine, and diethylaminoethylstearamide. 0 Also useful are dimethylstearamine, dimethylsoyamine, soyamine, myristylamine, tridecylamine, ethylstearylamine, N-tallowpropane diamine, ethoxylated (with 5 moles of ethylene oxide) stearylamine, dihydroxyethylstearylamine, and arachidyl behenylamine. 5 Particularly preferred is stearamidopropyldimethylamine. Mixtures of any of the foregoing materials may also be suitable. WO 2008/003677 PCT/EP2007/056643 The acid used to provide the cationic species can be any organic acid or mineral acid of sufficient acid strength to neutralise a free amine nitrogen. Such acids include hydrochloric acid, sulphuric acid, nitric acid, phosphoric 5 acid, lactic acid, citric acid, tartaric acid, acetic acid, gluconic acid, glycolic acid and propionic acid, or combinations thereof. In general, a sufficient amount of acid is added to neutralise the amidoamine compound and to adjust the final pH of the composition to within a range of 10 from about 2.5 to about 6, preferably in a pH range of from about 3 to about 5. The molar ratio of protonatable amine groups to H+ from the acid is preferably from about 1:0.3 to 1:1.2, and more preferably from about 1:0.5 to about 1:1.1. 15 Mixtures of any of the above-described cationic surfactants may also be suitable. In the composition of the invention, the level of cationic surfactant preferably ranges from 0.1 to 10%, more preferably 20 0.2 to 5%, most preferably 0.25 to 4% by total weight of cationic surfactant based on the total weight of the composition. It is preferred if the weight ratio of cationic surfactant 25 to antidandruff agent is in the ratio of 4:1 to 1:4, preferably 1:2 to 2:1 Fatty Material 30 Compositions of the invention may comprise a fatty material. The fatty material, together with the cationic surfactant and WO 2008/003677 PCT/EP2007/056643 an aqueous carrier, forms a lamellar gel phase which is suitable for providing various hair conditioning attributes. By "fatty material" is meant a compound having the general 5 formula R-X, wherein R is an aliphatic carbon chain and X is a functional group (e.g. alcohol, acid, or derivative). R is preferably a fully saturated aliphatic carbon chain comprising from 8 to 30 carbon atoms, more preferably from 16 10 to 22 carbon atoms. X is preferably an alcohol group. Most preferably, the fatty material is selected from cetyl 15 alcohol, stearyl alcohol, behenyl alcohol, and mixtures thereof. The level of fatty material in conditioners of the invention suitably ranges from 0.01 to 15%, preferably from 0.1 to 10%, 20 and more preferably from 0.1 to 5% by total weight fatty material based on the total weight of the composition. The weight ratio of cationic surfactant to fatty material is suitably from 10:1 to 1:10, preferably from 4:1 to 1:8, more 25 preferably from 1:1 to 1:7. Aqueous Carrier The conditioning composition of the present invention 30 preferably comprises an aqueous carrier. WO 2008/003677 PCT/EP2007/056643 Suitable aqueous carriers are water and water solutions of lower alkyl alcohols and polyhydric alcohols. Examples of suitable lower alkyl alcohols are monohydric 5 alcohols having 1 to 6 carbons, preferably ethanol and isopropanol. Examples of suitable polyhydric alcohols are propylene glycol, hexylene glycol, glycerin, and propanediol. 10 Preferably, the aqueous carrier is substantially water. Generally, compositions according to the invention comprise at least 60%, preferably at least 65%, more preferably at 15 least 70% water by weight based on the total weight of the composition. Further Conditioning Agents 20 Compositions of the invention may comprise further conditioning agents to optimise wet and dry conditioning benefits. Particularly preferred further conditioning agents are 25 silicone emulsions. Suitable silicone emulsions include those formed from silicones such as polydiorganosiloxanes, in particular polydimethylsiloxanes which have the CTFA designation 30 dimethicone, polydimethyl siloxanes having hydroxyl end groups which have the CTFA designation dimethiconol, and WO 2008/003677 PCIYEP2007/056643 amino-functional polydimethyl siloxanes which have the CTFA designation amodimethicone. Mixtures of any of the above described silicone emulsions may also be used. 5 Silicone will generally be present in a composition of the invention at levels of from 0.05 to 10%, preferably 0.05 to 5%, more preferably from 0.5 to 2% by total weight of silicone based on the total weight of the composition. 10 Other Optional Ingredients 15 Compositions according to the invention may also incorporate other cosmetically suitable ingredients, preferably at a level of 2% by weight or less. Suitable ingredients include: preservatives, colouring agents, chelating agents, antioxidants, fragrances, cationic conditioning polymers, 20 styling ingredients, sunscreens, proteins and hydrolysed proteins. Use 25 The compositions of the invention may be used by applying them to wet hair, typically hair which has been shampooed and then rinsed with water. Generally, the composition is applied to the hair and then 30 worked through the hair. Preferably the composition is then WO 2008/003677 PCT7EP2007/056643 left to penetrate the hair for a period of about one to three minutes before rinsing it from the hair with water. The invention will now be further described by reference to 5 the following Examples. In the Examples, all percentages are by weight based on total weight, unless otherwise specified. Examples according to the invention are denoted by a number, whereas comparative examples are denoted by a letter. 10 EXAMPLES Hair conditioning compositions were prepared having ingredients as shown in the following Table 1: Table 1 15 WO 2008/003677 PCT/EP2007/056643 The compositions were evaluated for the level of climbazole deposited on skin as follows: 5 Product treatment Artificial skin was snapped onto plastic cylinders prior to product treatment. Test shampoos were stirred and rubbed 10 onto the artificial skin, at dilution of 1:3, using a wide diameter stirring rod for 30 seconds. Shampoo liquor was then removed from the artificial skin, followed by adequate rinsing with distilled water to remove any residual surfactants. Climbazole that was deposited from shampoo onto 15 artificial skin was then extracted by ethanol. The ethanolic solution was then filtered through a 0.45 urn filter to remove any impurities. Samples were analysed using HPLC. The results of the evaluation are shown below in Table 2: 20 Table 2 Climbazole deposition (fj.g/cm2 Example A 8.37 Example 1 27.33 Thus the example according to the invention deposited more 25 climbazole onto the skin than the comparative example. .Printed: 2d/p5/2008 • CLMSPAMD EP2007056643 J3833' (C) WO Amended 7 February 2008 CLAIMS 1. A hair conditioning composition comprising i) a cationic surfactant; ii) a triglyceride oil; and iii) 5 an anti dandruff agent selected from the group consisting of zinc pyrithione, octopirox, climbazole and ketoconazole. 2. A hair conditioning composition according to claim 1, 10 in which the triglyceride oil is selected from the group consisting of avocado oil, olive oil, corn oil, rape seed oil, sesame oil, wheat germ oil, castor oil, linseed oil, sunflower oil, cottonseed oil, soybean oil, peanut oil, and mixtures thereof. 15 3. A hair conditioning composition according to claim 2 in which the triglyceride oil is sunflower oil. 4. A hair conditioning composition according to any 20 preceding Cxaim in which the antidandruff agent is climbazole. 5. A hair conditioning composition according to any preceding claim in which the ratio of antidandruff agent 25 to sunflower oil is from 1:3 to 2:1 6. A hair conditioning composition according to any preceding claim further comprising a fatty alcohol. AMENDED SHEET 20/02/2008 Printed: 20/05/2008 CLMSPAMD EP2007056643 J3833'(C) WO Amended 7 February 2008 7. A method of mitigating dandruff by applying to the scalp to the scalp a composition according to any preceding claim. Dated this 5th day of January 2009 AMENDED SHEET 20/02/2008,.

Full Text

FORM - 2
THE PATENTS ACT, 1970
(39 of 1970)
&
The Patents Rules, 2003

COMPLETE SPECIFICATION
(See Section 10 and Rule 13)
ANTI-DANDRUFF HAIR CONDITIONING COMPOSITIONS
HINDUSTAN UNILEVER LIMITED, a company incorporated under
the Indian Companies Act, 1913 and having its registered office
at 165/166, Backbay Reclamation, Mumbai -400 020, Maharashtra, India

The following specification particularly describes the invention and the manner in which it is to be performed

WO 2008/003677

PCT/EP2OO7/056643

HAIR CONDITIONING COMPOSITIONS
FIELD OF THE INVENTION
5 The present invention relates to hair conditioning compositions which comprise an antidanclruf f agent.
BACKGROUND TO THE INVENTION AND PRIOR ART
10 There is a need for effective compositions for the treatment of dandruff. One way of solving this problem is to prepare compositions that give better deposition of an antidandruff agent onto the hair and/or the scalp.
15 The present invention is based on the Surprising finding that conditioning formulations can be formulated that give excellent deposition of antidandruff Agents.
20 SUMMARY OF THE INVENTION
The invention provides a hair conditioning composition comprising a hair conditioning composition comprising a cationic surfactant, triglyceride oil ^nd an anti dandruff 2 5 agent.
The invention also provides a method of mitigating dandruff by applying to the scalp to the scalp a composition as described above. 30

WO 2008/003677

PCT/EP2007/056643

DETAILED DESCRIPTION OF THE INVENTION
Antidandruff Agent 5
Compositions of the invention comprise an anti-dandruff
agent. Preferred antidandruff agents include zinc
pyrithione, octopirox, climbazole and ketoconazole.
10 Preferably, the anti-dandruff agent is in solution in the composition. The anti-dandruff agent is therefore preferably soluble in the composition of the invention at 25 degrees C. Most preferably, the anti-dandruff agent is climbazole (1-imidazolyl-l-(4-chlorophenoxy)-3,3-
15 dimethylbutan-2-one).
The anti-dandruff agent may be a single anti-dandruff compound or a mixture of different anti-dandruff compounds.
20 Preferably, the anti-dandruff agent is present in the
composition in an amount of from 0.1 to 5% by weight, more preferably from 0.1 to 2% by weight.
Triglyceride Oil
25
The hair conditioning composition of the invention comprises
a triglyceride oil, preferred oils include avocado oil/
olive oil, corn oil, rape seed oil, sesame oil, wheat germ
oil, castor oil, linseed oil, sunflower oil, cottonseed oil,
30 soybean oil, peanut oil, and mixtures thereof. Particularly
preferred is sunflower oil.

WO 2008/003677

PCT/EP2007/056643

The level of triglyceride oil is preferably from 0.1 to 10 wt% of the total composition, more preferably from 0.5 to 5 wt%, most preferably from 1 to 3 wt%.
5 The weight ratio of antidandruff agent to sunflower oil is preferably from 1:4 to 4:1, more preferably from 1:3 to 2:1, most preferably from 1:1 to 1:3.
Cationic Surfactant 10
Compositions according to the invention comprise one or more cationic surfactants which are cosmetically acceptable and suitable for topical application to the hair.
15 Suitable cationic surfactants for use in compositions of the invention contain amino or quaternary ammonium hydrophilic moieties which are positively charged when dissolved in the composition.
20 Suitable quaternary ammonium cationic surfactants correspond to the following general formula (I):
[NCR1) (R2) (R3) (R4)]+ (X)" (I)
25 in which R1, R2, R3, and R4 are each independently selected
from (a) an aliphatic group of from 1 to 22 carbon atoms, or (b) an aromatic, alkoxy, polyoxyalkylene, alkylamido, hydroxyalkyl, aryl or alkylaryl group having up to 22 carbon atoms; and X is a salt-forming anion such as those selected
30 from halogen, (e.g. chloride, bromide), acetate, citrate,

WO 2008/003677

PCT/EP2007/056643

lactate, glycolate, phosphate nitrate, sulphate, and alkylsulphate radicals.
The aliphatic groups can contain, in addition to carbon and 5 hydrogen atoms, ether linkages, and other groups such as
amino groups. The longer chain aliphatic groups, e.g., those of about 12 carbons, or higher, can be saturated or unsaturated.
10 In a suitable class of cationic surfactant of general
formula (I), R1 and R2 are each independently selected from Cis to C22 hydrocarbyl chains comprising at least one ester linkage in both R1 and R2, and R3 and R4 are each independently selected from CH3 and CH2CH2OH.
15
In another suitable class of cationic surfactant of general formula (I), R1 and R2 are each independently selected from C16 to C22 saturated or unsaturated, preferably saturated, chains, and R3 and R4 are each independently selected from
20 CH3 and CH2CH2OH, preferably CH3.
In a preferred class of cationic surfactant of general formula (I), R1 is a Ci6 to C22 alkyl chain and R2, R3 and R4 are each independently selected from CH3 and CH2CH2OH, 25 preferably CH3.
Specific examples of suitable quaternary ammonium cationic surfactants of general formula (1} are cetyltrimethylammonium chloride, behenyltrimethylammonium chloride (BTAC), 30 cetylpyridinium chloride, tetramethylammonium chloride,
tetraethylammonium chloride, octyltrimethylammonium chloride,

WO 2008/003677

PCTYEP2007/056643

dodecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, octyldimethylbenzylammonium chloride, decyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, 5 didodecyldimethylammonium chloride,
dioctadecyldimethylammonium chloride, tallowtrimethylammonium chloride, cocotrimethylammonium chloride, dipalmitoylethyldimethylammonium chloride, PEG-2 oleylammonium chloride and salts of these, where the chloride 10 is replaced by halogen, (e.g., bromide), acetate, citrate, lactate, glycolate, phosphate nitrate, sulphate, or alkylsulphate. Particularly preferred is behenyltrimethylammonium chloride (BTAC)
15 Mixtures of any of the foregoing materials may also be suitable.
Salts of primary, secondary, and tertiary fatty amines are also suitable cationic surfactants for Use in the invention. 20 The alkyl groups of such amines preferably have from about 12 to about 22 carbon atoms, and can be substituted or unsubstituted. Th^se amines are typically used in combination with an acid to provide the cationic species.
25 A preferred class 0f amine corresponds to the following general formula HZ);
R1 - C(O) - N(H)- fc2 - N(R3) (R4) (II)
30

WO 2008/003677

PCT/EP2007/056643

in which R1 is a fatty acid chain containing from 12 to 22
carbon atoms, R2 is an alkvlene group containing from one to
four carbon atoms, and R3 and R4 are, independently, an alkyl
group having from one to four carbon atoms. 5
Specific examples of suitable materials of general formula
(II) are stearamidopropyldimethylamine,
s tear ami dopropyldiethylamine, s tear amidoe'thyldie thy lamine,
stearamidoethyldimethylamine, palmitamidopropyldimethylamine, 0 palmitamidopropyldiethylamine, palmitamidoethyldiethylamine,
palmitamidoethyldimethylamine, behenamidopropyldimethylamine,
behenamidopropyldiethylamine, behenamidoethyldiethylamine,
behenamidoethyldimethylamine,
arachidamidopropyldimethylamine, 5 arachidamidopropyldiethylamine,
arachidamidoethyldiethylamine,
arachidamidoethyldimethylamine, and
diethylaminoethylstearamide.
0 Also useful are dimethylstearamine, dimethylsoyamine,
soyamine, myristylamine, tridecylamine, ethylstearylamine, N-tallowpropane diamine, ethoxylated (with 5 moles of ethylene oxide) stearylamine, dihydroxyethylstearylamine, and arachidyl behenylamine.
5
Particularly preferred is stearamidopropyldimethylamine.
Mixtures of any of the foregoing materials may also be suitable.

WO 2008/003677

PCT/EP2007/056643

The acid used to provide the cationic species can be any organic acid or mineral acid of sufficient acid strength to neutralise a free amine nitrogen. Such acids include hydrochloric acid, sulphuric acid, nitric acid, phosphoric 5 acid, lactic acid, citric acid, tartaric acid, acetic acid, gluconic acid, glycolic acid and propionic acid, or combinations thereof. In general, a sufficient amount of acid is added to neutralise the amidoamine compound and to adjust the final pH of the composition to within a range of 10 from about 2.5 to about 6, preferably in a pH range of from about 3 to about 5. The molar ratio of protonatable amine groups to H+ from the acid is preferably from about 1:0.3 to 1:1.2, and more preferably from about 1:0.5 to about 1:1.1.
15 Mixtures of any of the above-described cationic surfactants may also be suitable.
In the composition of the invention, the level of cationic surfactant preferably ranges from 0.1 to 10%, more preferably 20 0.2 to 5%, most preferably 0.25 to 4% by total weight of cationic surfactant based on the total weight of the composition.
It is preferred if the weight ratio of cationic surfactant 25 to antidandruff agent is in the ratio of 4:1 to 1:4, preferably 1:2 to 2:1
Fatty Material
30 Compositions of the invention may comprise a fatty material. The fatty material, together with the cationic surfactant and

WO 2008/003677

PCT/EP2007/056643

an aqueous carrier, forms a lamellar gel phase which is suitable for providing various hair conditioning attributes.
By "fatty material" is meant a compound having the general 5 formula R-X, wherein R is an aliphatic carbon chain and X is a functional group (e.g. alcohol, acid, or derivative).
R is preferably a fully saturated aliphatic carbon chain comprising from 8 to 30 carbon atoms, more preferably from 16 10 to 22 carbon atoms.
X is preferably an alcohol group.
Most preferably, the fatty material is selected from cetyl 15 alcohol, stearyl alcohol, behenyl alcohol, and mixtures thereof.
The level of fatty material in conditioners of the invention suitably ranges from 0.01 to 15%, preferably from 0.1 to 10%, 20 and more preferably from 0.1 to 5% by total weight fatty material based on the total weight of the composition.
The weight ratio of cationic surfactant to fatty material is suitably from 10:1 to 1:10, preferably from 4:1 to 1:8, more 25 preferably from 1:1 to 1:7.
Aqueous Carrier
The conditioning composition of the present invention 30 preferably comprises an aqueous carrier.

WO 2008/003677

PCT/EP2007/056643

Suitable aqueous carriers are water and water solutions of lower alkyl alcohols and polyhydric alcohols.
Examples of suitable lower alkyl alcohols are monohydric 5 alcohols having 1 to 6 carbons, preferably ethanol and isopropanol.
Examples of suitable polyhydric alcohols are propylene glycol, hexylene glycol, glycerin, and propanediol. 10
Preferably, the aqueous carrier is substantially water.
Generally, compositions according to the invention comprise at least 60%, preferably at least 65%, more preferably at 15 least 70% water by weight based on the total weight of the composition.
Further Conditioning Agents
20 Compositions of the invention may comprise further
conditioning agents to optimise wet and dry conditioning benefits.
Particularly preferred further conditioning agents are 25 silicone emulsions.
Suitable silicone emulsions include those formed from silicones such as polydiorganosiloxanes, in particular polydimethylsiloxanes which have the CTFA designation 30 dimethicone, polydimethyl siloxanes having hydroxyl end groups which have the CTFA designation dimethiconol, and

WO 2008/003677

PCIYEP2007/056643

amino-functional polydimethyl siloxanes which have the CTFA designation amodimethicone.
Mixtures of any of the above described silicone emulsions may also be used. 5
Silicone will generally be present in a composition of the invention at levels of from 0.05 to 10%, preferably 0.05 to 5%, more preferably from 0.5 to 2% by total weight of silicone based on the total weight of the composition. 10
Other Optional Ingredients
15 Compositions according to the invention may also incorporate other cosmetically suitable ingredients, preferably at a level of 2% by weight or less. Suitable ingredients include: preservatives, colouring agents, chelating agents, antioxidants, fragrances, cationic conditioning polymers,
20 styling ingredients, sunscreens, proteins and hydrolysed proteins.
Use
25 The compositions of the invention may be used by applying them to wet hair, typically hair which has been shampooed and then rinsed with water.
Generally, the composition is applied to the hair and then 30 worked through the hair. Preferably the composition is then

WO 2008/003677

PCT7EP2007/056643

left to penetrate the hair for a period of about one to three minutes before rinsing it from the hair with water.
The invention will now be further described by reference to 5 the following Examples. In the Examples, all percentages are by weight based on total weight, unless otherwise specified. Examples according to the invention are denoted by a number, whereas comparative examples are denoted by a letter.
10 EXAMPLES
Hair conditioning compositions were prepared having ingredients as shown in the following Table 1: Table 1
15

WO 2008/003677

PCT/EP2007/056643

The compositions were evaluated for the level of climbazole deposited on skin as follows:
5
Product treatment
Artificial skin was snapped onto plastic cylinders prior to product treatment. Test shampoos were stirred and rubbed
10 onto the artificial skin, at dilution of 1:3, using a wide diameter stirring rod for 30 seconds. Shampoo liquor was then removed from the artificial skin, followed by adequate rinsing with distilled water to remove any residual surfactants. Climbazole that was deposited from shampoo onto
15 artificial skin was then extracted by ethanol. The ethanolic solution was then filtered through a 0.45 urn filter to remove any impurities. Samples were analysed using HPLC.
The results of the evaluation are shown below in Table 2: 20
Table 2

Climbazole deposition (fj.g/cm2
Example A 8.37
Example 1 27.33
Thus the example according to the invention deposited more 25 climbazole onto the skin than the comparative example.

.Printed: 2d/p5/2008 • CLMSPAMD EP2007056643
J3833' (C) WO
Amended 7 February 2008
CLAIMS
1. A hair conditioning composition comprising i) a
cationic surfactant; ii) a triglyceride oil; and iii)
5 an anti dandruff agent selected from the group
consisting of zinc pyrithione, octopirox, climbazole and ketoconazole.
2. A hair conditioning composition according to claim 1,
10 in which the triglyceride oil is selected from the
group consisting of avocado oil, olive oil, corn oil, rape seed oil, sesame oil, wheat germ oil, castor oil, linseed oil, sunflower oil, cottonseed oil, soybean oil, peanut oil, and mixtures thereof. 15
3. A hair conditioning composition according to claim 2
in which the triglyceride oil is sunflower oil.
4. A hair conditioning composition according to any
20 preceding Cxaim in which the antidandruff agent is
climbazole.
5. A hair conditioning composition according to any
preceding claim in which the ratio of antidandruff agent
25 to sunflower oil is from 1:3 to 2:1
6. A hair conditioning composition according to any
preceding claim further comprising a fatty alcohol.

AMENDED SHEET

20/02/2008

Printed: 20/05/2008 CLMSPAMD EP2007056643
J3833'(C) WO
Amended 7 February 2008
7. A method of mitigating dandruff by applying to the scalp to the scalp a composition according to any preceding claim.
Dated this 5th day of January 2009

AMENDED SHEET

20/02/2008,.

Documents:

34-MUMNP-2009-ANNEXURE TO FORM 3(3-10-2012).pdf

34-MUMNP-2009-CLAIMS(AMENDED)-(25-2-2014).pdf

34-MUMNP-2009-CLAIMS(AMENDED)-(3-10-2012).pdf

34-MUMNP-2009-CLAIMS(MARKED COPY)-(25-2-2014).pdf

34-MUMNP-2009-CLAIMS(MARKED COPY)-(3-10-2012).pdf

34-mumnp-2009-claims.doc

34-mumnp-2009-claims.pdf

34-MUMNP-2009-CORRESPONDECE(28-4-2010).pdf

34-MUMNP-2009-CORRESPONDENCE(10-12-2013).pdf

34-MUMNP-2009-CORRESPONDENCE(12-08-2011).pdf

34-MUMNP-2009-CORRESPONDENCE(15-2-2011).pdf

34-MUMNP-2009-CORRESPONDENCE(21-10-2013).pdf

34-MUMNP-2009-CORRESPONDENCE(22-6-2013).pdf

34-MUMNP-2009-CORRESPONDENCE(23-1-2013).pdf

34-MUMNP-2009-CORRESPONDENCE(27-2-2013).pdf

34-MUMNP-2009-CORRESPONDENCE(8-8-2012).pdf

34-mumnp-2009-correspondence.pdf

34-mumnp-2009-discription(complete).doc

34-mumnp-2009-discription(complete).pdf

34-mumnp-2009-form 1.pdf

34-MUMNP-2009-FORM 18(28-4-2010).pdf

34-mumnp-2009-form 2(title page).pdf

34-mumnp-2009-form 2.doc

34-mumnp-2009-form 2.pdf

34-MUMNP-2009-FORM 3 (22-6-2013).pdf

34-MUMNP-2009-FORM 3(10-12-2013).pdf

34-MUMNP-2009-FORM 3(12-08-2011).pdf

34-MUMNP-2009-FORM 3(15-2-2011).pdf

34-MUMNP-2009-FORM 3(15-2-2012).pdf

34-MUMNP-2009-FORM 3(23-1-2013).pdf

34-MUMNP-2009-FORM 3(24-2-2010).pdf

34-MUMNP-2009-FORM 3(4-8-2010).pdf

34-MUMNP-2009-FORM 3(8-8-2012).pdf

34-mumnp-2009-form 3.pdf

34-mumnp-2009-form 5.pdf

34-MUMNP-2009-GENERAL POWER OF ATTORNEY(3-10-2012).pdf

34-mumnp-2009-international publication report a2.pdf

34-mumnp-2009-international publication report a3.pdf

34-mumnp-2009-pct-ipea-409.pdf

34-mumnp-2009-pct-ipea-416.pdf

34-mumnp-2009-pct-isa-210.pdf

34-MUMNP-2009-REPLY TO EXAMINATION REPORT(3-10-2012).pdf

34-MUMNP-2009-REPLY TO HEARING(25-2-2014).pdf

34-MUMNP-2009-US DOCUMENT(3-10-2012).pdf

« Previous Patent

Next Patent »

Patent Number

259680

Indian Patent Application Number

34/MUMNP/2009

PG Journal Number

13/2014

Publication Date

28-Mar-2014

Grant Date

22-Mar-2014

Date of Filing

05-Jan-2009

Name of Patentee

HINDUSTAN UNILEVER LIMITED

Applicant Address

UNILEVER HOUSE, B.D. SAWANT MARG, CHAKALA, ANDHERI(EAST), MUMBAI-400 099, MAHARASHTRA, INDIA

Inventors:

#	Inventor's Name	Inventor's Address
1	CHANG WANLIN	UNILEVER THAI TRADING LTD, 18 SCB PARK PLAZA, BUILDING 1, RATCHADAPISEK ROAD, LADYAO, JATUJAK, BANGKOK 10900, THAILAND.
2	PHATTARASAKUL KANJANA	UNILEVER THAI TRADING LTD, 18 SCB PARK PLAZA, BUILDING 1, RATCHADAPISEK ROAD, LADYAO, JATUJAK, BANGKOK 10900,
3	SAMRAN BUSARAPOM	UNILEVER THAI TRADING LTD, 18 SCB PARK PLAZA, BUILDING 1, RATCHADAPISEK ROAD, LADYAO, JATUJAK, BANGKOK 10900,
4	ZHU JIE BING	UNILEVER R&D LABORATORY SHANGHAI, 8/F TOWER A, CITY CENTRE OF SHANGHAI, 100 ZUNYI ROAD, 200051 SHANGHAI,

PCT International Classification Number

A61Q5/00

PCT International Application Number

PCT/EP2007/056643

PCT International Filing date

2007-07-02

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	EP06253590	2006-07-07	EUROPEAN UNION