Title of Invention

"THIENO [2,3-C]PYRAZOLE DERIVATIVES OF FORMULA (I)"

Abstract

Thieno [2,3-c]pyrazole derivatives of formula (i) wherein R is an optionally substituted aryl or heteroaryl group; R1 and R2 represent, the same or different and independently from each other, a hydrogen atom, a straight or branched C1-C3 alkyl or a group -CONH2 or -CH2NR'R" or, taken together with the carbon atom to which they are bonded, R1 and R2 may form a C3-C6 cycloalkyl group; with the proviso that at least one of R1 and R2 is other than a hydrogen atom; R' and R" represent, the same or different and independently from each other, a hydrogen atom or a straight or branched C1-C3 alkyl group or, taken together with the nitrogen atom to which they are bonded, R1 and R" may form a heterocyclic ring of formula wherein R'" is a hydrogen atom or a straight or branched C1-C3 alkyl group; R3 is a hydrogen or halogen atom or a group selected from hydroxy, cyano, straight or branched C1-C3 alkyl or C1-C3 alkoxy; or stereoisomers, tautomers, and pharmaceutically acceptable salts thereof with the proviso that the compound not have one of R1 and R2 be a hydrogen atom, the other one of R1 and R2 be a C1-C3 alkyl and R be a 4-(l-methyl-piperazin-4-yl)phenyl.

Full Text

TITLE OF THE INVENTION 1H-THIENO[2,3-c]PYRAZOLE DERIVATIVES USEFUL AS KINASE INHIBITORS BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to thieno-pyrazole derivatives, to a process for their preparation, to pharmaceutical compositions comprising them, and to their use as therapeutic agents, particularly in the treatment of cancer and cell proliferation disorders. Discussion of thejjackcjround The malfunctioning of protein kinases (PKs) is the hallmark of numerous diseases. A large share; of the oncogenes and proto-oncogenes involved in human cancers code for PKs The enhanced activities of PKs are also implicated in many non-malignant diseases, such as benign prostate hyperplasia, familial adenomatosis, polyposis, neuro-fibromatosis, psoriasis, vascular smooth cell proliferation associated with atherosclerosis, pulmonary fibrosis, arlhriiis glomerulonephntis and post-surgical stenosis and restenosis. PKs are also implicated in inflammatory conditions and in the multiplication of viruses and parasites, PKs may also play a major role in the pathogenesis and development of neurodegenerative disorders, For a general reference to PKs 'malfunctioning or disregulation see, for instance, Current Opinion in Chemical Biology 1999, 3, 459 - 465. Among the several protein kinases known in the art as being implicated in the growth of cancer cells are Aurora kinases, in particular Aurora-2. Aurora-2 was found to be over-expressed in a number of different tumor types. Its gene locus maps at 20q13, a chromosomal region frequently amplified in many cancers, including breast [Cancer Res. 1999, 59(9), 2041-4] and colon. 20q13 amplification correlates with poor prognosis in patients with node-negative breast cancer and increased Aurora-2 expression is indicative of poor prognosis and decreased survival time in bladder cancer patients [J. Natl, Cancer Inst., 2002, 94(17), 1320- 9]. For a general reference to Aurora-2 role in the abnormal centre-some function in cancer see also Molecular Cancer Therapeutics, 2003, 2, 589 - 595 and Curr. Opin. Genet. & Dev. 2004, 14(1), 29-36. SUMMARYjOF THE INVENTION II is an object of the invention to provide compounds, which are useful in therapy as agents against a host of diseases caused by and/or associated to a disregulated protein kinase activity and, more particularly, Aurora kinases activity. It is another object to provide compounds, which are endowed with protein kinase inhibiting activity and, more particularly, Aurora kinases inhibiting activity. The present inventors have now discovered that some thieno-pyrazole compounds, and derivatives thereof, are endowed with protein kinase inhibiting activity, e.g. Aurora kinases inhibiting activity. More specifically, the compounds of this invention are useful in the treatment of a variety of cancers including, but not limited to: carcinoma such as bladder, breast, colon, kidney, liver, lung, including small cell iung cancer, esophagus, gall-bladder, ovary, pancreas, stomach, cervix, thyroid, prostate, and skin, including squamous cell carcinoma; hematopoietic tumors of lymphoid lineage, including leukemia, acufe lymphocitic leukemia, acute lyrnphoblastic leukemia, B-cell lymphoma, T-celMymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, hairy cell lymphoma and Burkett's lymphoma; hematopoietic tumors of myeloid lineage, including acute and chronic myelogenous leukemias, myelodysplastic syndrome and promyelocytic leukemia; tumors of mesenchymai origin, including fibrosarcoma and rhabdornyosarcoma; tumors of the central and peripheral nervous system, including astrocyioma, neuroblastoma, glioma and schwannomas; other tumors, including melanoma, serninoma, ieratpcarcinoma, osteosarcoma, xeroderma pigmentosum, keratoxanthoma, thyroid follicular cancer and Kaposi's sarcoma. Due to (he key role of PKs and Aurora kinases in the regulation of cellular proliferation, these thieno-pyrasole derivatives are also useful in She treatment of a variety of cell proliferate disorders such as, for instance, benign prostaie hyperplasia, familial adenomatosis, polyposis, neuro-fibromatosis, psoriasis, vascular smooth cell proliferation associated with atherosclerosis, pulmonary fibrosis, arthritis glomerulonephritis and post-surgical stenosis and resfenosis. Accordingly, in a first embodiment, the present invention provides a method for treating cell proliferative disorders caused by and/or associated with an altered protein kinase (Figure Removed) activity, which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I) wherein R is an optionally substituted aryl or heteroaryl group; R1 and R2 represent, the same or different and independently from each other, a hydrogen atom, a straight or branched C,-C3 alkyl or a group -CONH2 or -CH2NR'R" or, taken together with the carbon atom to which they are bonded, R, and R2 may form a C3-C6 cycloalkyl group; with the proviso that at least one of R, and R2 is other than a hydrogen atom; R' and R" represent, the same or different and independently from each other, a hydrogen atom or a straight or branched C^-C3 alkyl group or, taken together with the nitrogen atom to which they are bonded, R' and R" may form a heterocyclic ring of formula (Figure Removed) wherein R'" is a hydrogen atom or a straight or branched CrC3 alkyl group; R3 is a hydrogen or halogen atom or a group selected from hydroxy, cyano, straight or branched CrC3 alkyl or CrC3 alkoxy; or isomers, tautomers, carriers, metabolites, prodrugs, and pharmaceutically acceptable salts thereof. The above method enables treatment of cell proliferative disorders caused by and/or associated with altered Aurora kinases activity. In a preferred embodiment of the method described above, the cell proliferative disorder is cancer. Specific types of cancer that may be treated include carcinoma, squamous cell carcinoma, hematopoietic tumors of myeloid or lymphoid lineage, tumors of mesenchymal origin, tumors of the central and peripheral nervous system, melanoma, seminoma, teratocarcinoma, osteosarcoma, xeroderma pigmentosum, keratoxanthoma, thyroid follicular cancer, and Kaposi's sarcoma. The present invention also provides a compound of formula (I) (Figure Removed) wherein R is an optionally substituted aryl or heteroaryl group; r! and R2 represent, the same or different and independently from each other, a hydrogen atom, a straight or branched CrC3 alkyl or a group -CONH2 or -CH2NR'R" or, taken together with the carbon atom to which they are bonded, R, and R2 may form a C3-C6 cycloalkyl group; with the proviso that at least one of Rj and R? is other than a hydrogen atom; R' and R" represent, the same or different and independently from each other, a hydrogen atom or a straighl or branched C,-C3 alkyl group or, taken together with the nitrogen atom to which they are bonded, R1 and R" may form a heterocyclic ring of formula (Figure Removed) wherein R"' is a hydrogen atom or a straight or branched C,-C3 alkyJ group; R3 is a hydrogen or halogen atom or a group selected from hydroxy, cyano, straight or branched C,-C3 alkyl or Cf-C3 alkoxy; or isomers, tautomers, carriers, metabolites, prodrugs, and pharmaceutically acceptable salts thereof. The present invention also includes methods of synthesizing the thieno-pyrazole compounds of formula (I) and Ihe pharmaceutically acceptable salts', as well as the pharmaceutical compositions comprising them. A more complete appreciation of the invention and many of the attendant advantages thereof will be readily oblained as the same becomes better understood by reference to the following detailed description. DETAILED DESCRIPTION OF THE INVENTION Several heterocyclic compounds are known in the art as protein kinase inhibitors. As an example, 2-carboxamido-pyrazole and 2-ureido-pyrazole derivatives have been disclosed as protein kinase inhibitors in the international patent applications WO 01/12189, WO 01/12188, WO 02/48114 and WO 02/70515, all in the name of the applicant itself. Fused bicyclic compounds comprising pyrazole moieties and possessing kinase inhibitory activity have been also disclosed in WO 00/69846, WO 02/12242,.'WO 03/028720, WO 03/097610 as well as in WO2004007504 and W02004013146 applications (respectively claiming priority from US 60/396,174 of July 17, 2002; and US 60/398,121 of July 25, 2002) ail in the name of the applicant itself. In addition, 5-phenylsulfonyl-thieno[2,3-c]pyrazole derivatives are also known in [he art as synthetic intermediates for the preparation of more complex heterocyclic structures, as reported in Monatshefte fur Chemie 128. 687-696 (1997). The compounds of the present invention fall within the scope of the general formula of the aforementioned WO2004013146 but are not specifically exemplified therein. The compounds of formula (I) of the invention have asymmetric carbon atoms and may therefore exist as individual optical isomers, as racemic mixtures or as any other mixture comprising a majority of one of the two optical isomers, which are all to be intended as within the scope of the present invention. Likewise, the use as an antitumor agent of all the possible isomers and their admixtures and of both the metabolites and the pharmaceutically acceptable bio-precursors (otherwise referred to as pro-drugs) of the compounds of formula (I) are also within the scope of the present invention. Prodrugs are any covalently bonded compounds, which release the active parent drug, according to formula (I), in vivo, In cases when compounds may exist in tautomeric forms, each form is contemplated as being included within this invention whether existing in equilibrium or predominantly in one form. As such, unless otherwise provided, when only one of the following tautomeric forms of formula (la) or (Ib) is indicated, the remaining one has still to be intended as comprised within the scope of the invention: (Figure Removed) In the present description, unless otherwise specified, with the term aryl group we intend any aromatic carbocyclic ring system of 1 or 2 ring moieties, either fused or linked to each other through a single bond, for instance including phenyl, D- or D-naphthyl or biphenyl groups, With the term heteroaryl we intend any aromatic heterocyclic ring which may comprise an optionally benzocondensed 5 or 6 mernbered heterocycle with from 1 to 3 heteroatoms selected among N, O or S, Npn limiting examples of heteroaryl groups according to the invention, may thus include, for instance, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, imidazolyl, thiazolyl, isothiazolyl, pyrrolyl, phenyl-pyrrolyl, furyl, phenyl-furyl, oxazolyl, isoxazolyl, pyrazolyl, thienyl, benzothienyl, isoindolinyl, benzoimidazolyl, quinolinyl, isoquinolinyl, 1,2,3-triazolyl, 1-phenyl-' 1,2,3-triazolyi, and the like. With the term straight or branched C,-C3 alkyl or CrC3 alko.xy we intend any of the groups such as methyl, ethyl, n-propyl, isopropyl, methoxy, ethoxy, n-propoxy and isopropoxy. With the term halogen atom we intend a fluorine, chlorine, bromine or iodine atom. With the term C3-C6 cycloalkyl we intend any group such as cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl. Clearly, as these same cycloalkyl groups may be formed when R, and R2 are taken together with the carbon atom to which they are attached, cyclic spiro compounds may be thus obtained. Just as an example, when ri and R2 together form a cyclopentyl group, derivatives having the following general formula are herewith considered: (Figure Removed) When considering derivatives of formula (I) wherein R-i or R2 represents a group -CH2NR'R" and .R' and R" are linked together with the nitrogen atom to which they are attached, heterocyclic moieties may be thus formed as per the general formula. Just as an example, by considering R, as hydrogen and R2 as a group -CH2NR'R" with R' and R" linked together so as to form .a pyrrolidinyl-1-yl group, compounds having the following general formula formula are herewith considered: (Figure Removed) From all of the above, it is clear to the skilled man that the compounds of formula (I) of the invention are characterized by the presence of a moiety, hereinafter simply referred to as benzylamino moiety, wherein the methylene group is necessarily substituted by at least one of the groups R, and R2 which is different from hydrogen. According to the meanings provided to R, any of the above aryl or heteroaryl groups may be optionally further substituted in any of their free positions by one or more groups, for instance 1 to 6 groups, selected from: halogen, nitro, carboxy, cyano, alkyl, polytluorinated alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl; aryl, heterocyclyl, alkyl-heterocyclyl, heterocyclyl-alkyl, amino-alkyl, amino groups and derivatives thereof such as, for instance, alkylarnino, dialkylamino, arylamino, diarylamino, ureido, alkylureido or arylureido; carbonylamino groups and derivatives thereof such as, for instance, formylamino, alkylcarbonylamino, alkenylcarbonylamino, arylcarbonylamino, alkoxycarbonylamino; hydroxy groups and derivatives thereof such as, for instance, alkoxy, polyfluorinated alkoxy, aryloxy, heterocylyloxy, alkylcarbonyloxy, arylcarbonyloxy, cycloalkenyloxy or alkylideneaminoxy; carbonyl groups arid derivatives thereof such as, for instance, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyi, cycloalkyloxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl; sulfurated derivatives such as, for instance, alkylthio, arylthio, alkylsulfonyl, arylsulfonyl, alkylsulfinyl, arylsulfinyl, arylsulfonyloxy, arninosulfonyl, alkylaminosulfonyl or dialkylaminosulfonyl. In their turn, whenever appropriate, each of the above substituents may be further substituted by one or more of the aforementioned groups. With the term alkyl or alkoxy group we intend, unless otherwise provided, any straight or branched C,-C6 alkyl or alkoxy group, hence comprehensive of the aforementioned C,-C3 alkyl or alkoxy groups and also comprising n-butyl, iso-butyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-butoxy, iso-butoxy, sec-butoxy, tert-butoxy, n-pentyloxy, n-hexyloxy, and the like. With the term alkenyl or alkynyl group we intend, unless otherwise provided, any unsaturated straight or branched C2-C6 alkenyl or alkynyl group such as, for instance, vinyl, allyl, 1-propenyl, isopropenyl, 1-, 2-or 3-butenyl, pentenyl, hexenyl, ethynyl, 1- or 2-propynyl, butynyl, pentynyl, hexynyl, and the like. With the term polyfluorinated alkyl or alkoxy we intend any straight or branched C,-Cs alkyl or alkoxy group as above defined, wherein more than one hydrogen atom is replaced by fluorine atoms such as, for instance, trifluoromethyl, trifluoromethoxy, 2,2,2-trifluoroethyl, 2,2,2-trifluoroethoxy, 1,2-difluoroethyl, 1,1,1,3,3,3-hexafluoropropyl-2-yl, and the like. With the term heterocycle, heterocyclyl or heterocyclic group we also intend an optionally berizocondensed 4 to 7 membered heterocycle, hence encompassing aromatic heterocyclic groups also known as heteroaryl groups, either saturated or partially unsaturated, with from 1 to 3 heteroatoms selected among N, O and S. Examples of these 4 or 7 membered heterocyclic groups are, for instance, 1,3-dioxolane, pyran, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazolidine, pyrazoline, piperidine, piperazine, morpholine, tetrahydrofuran, hexamethyleneirnine, 1,4-hexahydrodiazepine, azetidine, and the like. With the term cycloalkenyl we intend any of the aforementioned C3-C6 cycioalkyl groups further comprising a double bond such as, for instance, 2-cyclopenten-1-yl, 3-cyclopenten-1-yl, 1-cyclohexen-1-yl, 2-cyclqhexen-1-yl, 3-cyclohexen-1-yl, and the like. From all of the above, it is clear to the skilled man that any group which name has been identified as a composite name such as, for instance, cycloalkylalkyl, arylalkyl, heterocyclylalkyl, alkylthio, aryloxy, arylalkyloxy, alkylcarbonyloxy and the like, has to be intended as conventionally construed from the parts to which they derive. So far, as an example, the term alkoxy-heterocyclyl-alkyl stands for a straight or branched alkyl group substituted by a heterocycle further substituted by alkoxy, wherein alkyl, heterocycle and alkoxy are as above defined. Likewise, the term alkyl-heterocyclyloxy stands for a heterocyclyloxy group further substituted by alkyl. The term "pharmaceutically acceptable salts".embraces salts commonly used to form alkali rneial salts and to form addition salts of free acids or free bases. The nature of the salt is not acceptable acid addition salts of the compounds of the present invention may be prepared from an inorganic or organic acid. Examples of such inorganic acids are hydrochloric, hydrobromic, hydroiodic, nitric, carbonic, sulfuric, and phosphoric acid. Appropriate organic acids may be selected from aliphatic, cycloaliphatic, arorriatic, arylaliphatic, heterocyclic, carboxylic and sulfonic classes of organic acids, examples of which are formic, acetic, trifluoroacetic, propionic, succinic, glycolic, gluconic, lactic, malic, tartaric, citric, ascorbic, glucuronic, maleic, fumaric, pyruvic, aspartic, glutamic, benzole, anthranilic, mesylic, salicylic, p-hydroxybenzoic, phenylacetic, mandelic, embonic . (pamoic), methanesulfonic, ethanesulfonic, benzenesulfonic, pantothenic, toluenesulfonic, 2-hydroxyethanesulfonic, sulfanilic, stearic, cyclohexylaminosulfonic, algenic, hydroxybutyric, galactaric and galacturonic acid. Suitable pharmaceuticaliy acceptable base addition salts of the compounds of the present invention include metallic salts made from aluminum, calcium, lithium, magnesium, potassium, sodium and zinc or organic salts made from N,N'-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N-methyl-glucarnine) and procaine. All of these salts may be prepared by conventional means from the corresponding compounds of the present invention, for instance by reacting them with the appropriate acid or base. A preferred class of compounds of the invention is represented by the derivatives of formula (I) wherein R is a group, optionally further substituted, selected from thienyl, fury I, pyrrolyl and phenyl. More preferably, within the above class, are the derivatives of formula (I) wherein R is thienyl, furyl, pyrrolyl, N-methyl-pyrrolyl, phenyl and phenyl substituted by halogen atoms, heterocycles, amino-alkyl groups, heterocylyloxy or heterocyclylalkyl groups, Even more preferably, within the above class of compounds of formula (I), R is selected from 2-thJenyl, 2-furyl, 1-rnethyl-pyrrolyl-2-yl, phenyl, 4-fluorophenyl, 4-(1-methyl-piperidyl-4-yloxy)phenyl, 4-(1-methyl-piperazinyl-4-yr)phenyl, 4-(1-methyl-piperazinyl-4yl-methyl)phenyl 4-(pyrrolidin-l-yl)methyl-phenyl, 4-(piperidin-1-yl)methyl-phenyl, 4-(1~methyl~piperazin-4-yl)methy!-phenyl, 4-(morpholino-1-yl)methyl-phenyl, 4-(alkylamino)methyl-phenyl, 4-(dialkylamino)methyl-phenyl or 4-(morpholino-4-yl)phenyl. Another preferred class of compounds of the invention is represented by the derivatives of formula (I) wherein one of R Another preferred class of compounds of the invention is represented by the derivatives of formula (I) wherein Ri and R2l together with the' carbon atom to which they are attached, form a C3-C6 cycloalkyl group and, even more preferably, cyclopropyl or cyclopentyl. Another preferred class of compounds of the invention is represented by the derivatives of formula (I) wherein R, Rj and R2 are as set forth above and R3 represents a hydrogen, fluorine or chlorine atom, or a group selected from hydroxy, methoxy or cyano. For a reference to any specific compound of formula (I) of the invention, optionally in the form of a pharmaceutically acceptable salt, see the following experimental section. As formerly indicated, a further object of the present invention is represented by the process for preparing the compounds of formula (I) and the pharmaceutically acceptable salts thereof, which process comprises: a) reacting a compound of formula (II), wherein Alk stands for a lower alkyl group, with hydrazine or a hydrazine salt and reacting the thus obtained intermediate compound under acidic conditions so as to obtain a compound of formula (III) (Figure Removed) (b) reacting the compound of formula (III) with any suitable pyrazole nitrogen atom protecting agent, so as to obtain a compound of formula (IV), in any one of its tautomeric forms (IVa) or (IVb) (Figure Removed) c) acylating the compound of formula (IV) with a compound of formula (V), wherein R is as set forth above and 2 represents a suitable leaving group, so as to obtain a compound of formula (VI) (Figure Removed) d) selectively hydrolyzing the tert-butyl ester group so as to obtain a compound of formula (VII) (Figure Removed) a) reacting the compound of formula (VII) with a compound of formula (VIII) wherein R,, R2 and R3 are as set forth above, in the presence of any suitable condensing agent, so as to obtain a compound of formula (IX) (Figure Removed) f) deprotecting the compound of formula (IX) from the Q pyrazole nitrogen atom protecting group so as to obtain the compound of formula (I) and, whenever desired, converting the compound of formula (I) into a pharmaceutically acceptable salt or converting the salt thereof into the free compound of formula (I). A compound of formula I wherein R is an optionally substituted 4'-(arnino-methyl)phenyl group can be optionally prepared by: f) treating derivatives of formula IX, wherein R is a phenyl group substituted at position 4' with a chloromethyl group with ammonia or a primary or secondary amine to deprotect and convert them into a compound of formula I, wherein R is an optionally substituted 4'-(amino-methyl)phenyl group, as shown in the following scheme: (Figure Removed) The above process is an analogy process, which can be carried out according to methods known in the.art. From the above, it is clear to the person skilled in the art that if a compound of formula (I), prepared according to the above process, is obtained as an admixture of isomers, their separation into the single isomers of formula (I), carried out according to conventional techniques, is still within the scope of the present invention. According to step (a) of the process,' the reaction between a compound of formula (II) .and hydrazine or a hydrazine salt, for instance hydrazine dihydrochloride or hydrazine sulphate or acetate, can be carried out in the presence of catalytic amounts of an acid such as hydrochloric, acetic or sulphuric acid, or in the presence of catalytic amounts of a Lewis acid such as boron trifluoride dimethyl etherate. Alternatively, this same reaction may be also accomplished in the presence of catalytic amounts of a strong base such as sodium • methoxide. The reaction is carried out in a suitable solvent, such1 as, for instance, N,N'-dimethylformamide, tetrahydrofuran, 1,4-dioxane, acetonitrile, water, methanol or ethanol, at a temperature ranging from about room temperature to reflux and for a time varying from about 30 minutes to about 18 hours. According to a preferred embodiment, within the compounds of formula (II), Alk represents a straight or branched lower alkyl group, for instance a C-\-Cs alky! group and even more preferably a C-|-C4 alkyl group. Preferably, step (a) is carried out by reacting a compound of formula (II) with hydrazine hydrate in methanol, ethanol or tetrahydrofuran at a temperature ranging from room , temperature to refluxing temperature. The obtained tert-butyl 4-cyano-5-hydrazinothiophene-2-carboxylate intermediate can be either separated from the reaction medium and further processed as per the working examples or, alternatively, directly processed through cyclization so as to afford the compound of formula (III). Cyclization is carried out at a temperature ranging from about 15°C to about 50°C in methanol or ethanol, and in the -presence of catalytic amounts of a mineral acid such as hydrochloric or .sulphuric acid. According to step (b) of the process, the thus obtained thieno-pyrazole derivative of formula (III) is then protected, according to well-known methods, at the pyrazole nitrogen atom. As an example, the above protection may occur with an alkyl chlorocarbonate, in a suitable solvent such as tetrahydrofuran, dichloromethane, chloroform, acetonitrile, toluene or mixtures-thereof, at a temperature ranging from about -5°C to about 35°C and for a time varying from about 30 minutes to about 72 hours, in the presence of an opportune proton scavenger such as triethylamine or diisopropylethylamine. According to step (c) of the process, the compound of formula (IV) is then reacted with any suitable acylating agent of formula (V) so as to yield the compound of formula (VI), by working according to methods well known in the art for the preparation of carboxamido derivatives. Tipycally, within the compound of formula (V), Z represents a halogen atom and, even more preferably, a bromine or chlorine atom. The reaction is carried out in a suitable solvent such as, for instance, tetrahydrofuran, dimethylformamide, dichloromethane, chloroform, acetonitrile, toluene or mixtures thereof, at a temperature ranging from about -10°C to reflux and for a time varying from about 30 minutes to about 96 hours, in the presence of an opportune proton scavenger such as triethylamine, N,N-diisopropy!ethylamine or pyridine. From the above, it is clear to the skilled person that' the above protection at the pyrazole nitrogen atom, in step (b), is of particular advantage as it prevents that acylation with the compound of formula (V), in step (c), occurs at the pyrazole nitrogen atom. According to step (d) of the process, the carboxyester function of the compound of formula (VII) is selectively hydrolized so as to yield the corresponding carboxy group. The reaction is carried out under acidic conditions, preferably in the presence of hydrochloric acid in dioxane, by operating at room temperature and for a suitable time, for instance up to 72 hours. According to step (e) of the process, the compound of formula (VII) is then reacted with a suitable amino derivative of formula (VIII) so as to lead to the corresponding compound of formula (IX). From the above it is clear to the skilled person that this reaction may be accomplished in a variety of ways and operative conditions, which are widely known in the art for the preparation of carboxamides. As an example, the reaction between the compounds of formula (VII) and (VIII) can be carried out in the presence of a coupling agent such as, for instance, 2-(1H-benzotriazol-1-y!)- 1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU), 1,3-dicyclohexylcarbodiimide, 1,3- diisopropylcarbodiimide, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N- cyclohexylcarbodiirnide-N'-propyloxymethyl polystyrene or N-cyclohexylcarbodiimide-N'-methyl polystyrene, in a suitable solvent such as, for instance, dichloromethane, chloroform, tetrahydrofuran, diethyl ether, 1,4-dioxane, acetonitrile, toluene, or N.N-dimethylforrnamide at a temperature ranging from about ~10°C to reflux and for a suitable time, for instance from about 30 minutes to about 96 hours, The said reaction is optionally carried out in the presence of a suitable catalyst, for instance 4-dimethylaminopyridine, or in the presence of a further coupling reagent such as N-hydroxybenzotriazole. Alternatively, this same reaction can be also carried out, for example, through a mixed anhydride method, by using an alkyl chloroformate such as ethyl, iso-butyl, or iso-propyl chloroformate, in the presence of a tertiary base such as triethylamine, N,N-diisopropylethylarnine or pyridine, in a suitable solvent such as, for instance, toluene, dichloromethane, chloroform, tetrahydrofuran, acetonitrile, diethyl ether, 1,4-dioxane, or N,N-dirnethylfoirnamide, at a temperature ranging from about -30°C to room temperature. According to step (f) of the process, the compound of formula (IX) is deprotected at the pyrazole nitrogen atom under basic conditions and by working according to conventional techniques, for instance by treatment with aqueous sodium or potassium hydroxide in the presence of a suitable co-solvent such as methanol, ethanol, dimethylformamide, 1,4-dioxane, or by treatment with a tertiary amine such as triethylamine or N,N-diisopropy!ethylamine and by using an alcohol like methanol or ethanol as the solvent.Deprotection may occur at a temperature ranging from about 18°C to refiuxing temperature of the solvent, for a time varying from about 30 minutes to about 72 hours. Finally, according to step f) of the process, the benzylic chlorine atom of the compound of formula (IXa) is substituted by treatament with ammonia or a primary or secondary amine in a suitable solvente like as methanol, ethanol, tetrahydrofuran, dimethylformamide, at a temperature ranging from 0 °C to the reflux temperature of the solvent, in these conditions the simultaneous removal of the protecting group at the pyrazole nitrogen also occurs. If desired, the salification of a compound of formula (I) or the conversion of a corresponding salt thereof into the free compound (I), according to step (f) of the process, can be easily carried out according to well-known methods in the art. As it will be appreciated by the person skilled in the art, when preparing the compounds of formula (I) object of the invention, optional functional groups within both the starting materials or the intermediates thereof and which could give rise to unwanted side reactions, need to be properly protected according to conventional techniques. Likewise, the conversion of these latter into the free deprotected compounds may be carried out according to known procedures. So far, when .the thieno-pyrazole derivative of the process being protected at the pyrazoie nitrogen atom is properly functionalized through carboxamido formation, in steps (c) and (e) of the process, the subsequent deprotection may occur under mild operative conditions, hence allowing to obtain the desired compound of formula (I). Whenever desired, according to an alternative embodiment of the invention, the compound of formula (ill) of step (a) may be reacted with an excess of the compound of formula (V), by working as reported in step (c), so as to get the desired functionalization at the amino moiety and, in the meantime, the protection at the pyrazole nitrogen atom. Therefore, it is a further object of the invention a process for preparing the compounds of formula (I) and the pharmaceutically acceptable salts thereof, which process comprises: a') reacting the compound of formula (III) being obtained in step (a) of the process with an excess of a compound of formula (V), wherein R is as set forth above and Z represents a suitdOle leaving group, so as to obtain a compound of formula (X) (Figure Removed) b') deprotecting the compound of formula (X) at the pyrazole nitrogen atom, as per step (f) of the process, and further reacting the resultant compound according to the remaining steps (d) and (e). AH of the compounds of formula (11), (V) and (VIII) are known or can be obtained according to known methods. As an example, the starting material of formula (II) wherein Alk stands for methyl can be easily obtained as follows, by starting from commercially available ethyl 4-cyano-5-(methylthio)thiophene-2-carboylate: (Figure Removed) The hydrolysis of the ethoxycarbonyl group is carried out according to well-known methods, for instance in the presence of aqueous alkaline solutions such as aqueous sodium hydroxide. Likewise, esterification is carried out according to well-known operative conditions, in the presence of an alkylating agent like tert-butyl bromide or di-tertbutyl-dicarbonate, in a suitable solvent such as dimethylformamide or tetrahydrofuran. Finally, the conversion of the alkylthio group into alkylsulfonyl can be carried in the presence of any opportune oxidizing agent such as, for instance, hydrogen peroxide, 3- chloroperoxybenzoic acid or oxone, in a suitable solvent such as, for instance, dichloromethane, DMF, acetone, toluene, acetonitrile, methanol, ethanol, water, acetic acid, at a temperature ranging from about -10°C to reflux and for a time varying from about 30 minutes to about 4 days. For a general reference to the preparation of the compounds of formula (II) see, as an example, J. Bioorg. Med. Chem. Lett. 11(2001), 915-918; EP-A-234622; as well as the following experimental section. PHARMACOLOGY The compounds of formula (I) are. active as protein kinase inhibitors, more particularly as Aurora kinases inhibitors and are therefore useful, for instance, to restrict the unregulated proliferation of tumor cells. In therapy, they may be used in the treatment of various tumors, such as those formerly reported, as well as in the treatment of other cell proliferative disorders such as psoriasis, vascular smooth cell proliferation associated with atherosclerosis and post-surgical stenosis and restenosis. The inhibiting activity and the potency of selected compounds is determined through a method of assay based on the use of the SPA technology (Amersham Pharmacia Biotech). The assay consists of the transfer of radioactivity labelled phosphate moiety by the kinase to a biotinylated substrate. The resulting 33P-labelled biotinylated product is allowed to bind to streptavidin-ccated SPA beads (biotin capacity 130 pmol/mg), and light emitted was measured in a scintillation counter. |nj]]bjtion assay of Aurora-2 activity Kinase reaction: 8 uM biotinylated peptide (4 repeats of LRRWSLG), 10 uM ATP (0.5 uCi P33Y-ATP), 7.5 ng Aurora 2, inhibitor in z final volume of 30 yl buffer (HEPES 50 mM pH 7.0, MgCI2 10 mM, 1 rnM DTT, 0.2 mg/ml BSA, 3 uM orthovanadate) were added to each well of a 96 U bottom well plate. After 60 minutes at room temperature incubation, reaction was stopped and biolinylated peptide captured by adding 100 ul of bead suspension. Stratification: 100 yl of CsCI2 5 M were added to each well and let stand 4 hour before radioactivity was counted in the Top-Count instrument. IC50 determination: inhibitors were tested at different concentrations ranging from 0 0015 to 10 utvl. Experimental data were analyzed by the computer program GraphPad Prizm using the four parameter logistic equation: y = botfom+(top-bottom)/(1+10"((loglC50-x)*slope)) where x is the logarithm of the inhibitor concentration, y is the response; y starts at bottom and goes to top with a sigmoid shape, Ki calculation; Experimental method; Reaction was carried out in -buffer (10 mM Tris, pH 7.5, 10 mM MgCI2l 0,2 mg/mL BSA, 7.5 mM DTT) containing 3.7 nM enzyme, histone and ATP (constant ratio of cold/labeled ATP 1/3000). Reaction was stopped with EDTA and the substrate captured on phosphomembrane (Multiscreen 96 well plates from Miilipore), After extensive washing, the multiscreen plates were read on a top counter, Control (time zero) for each ATP and histone concentrations was measured. Experimental design: Reaction velocities are measured at four ATP, substrate {histone) and inhibitor concentrations. An 80-point concentration matrix was designed around the respective ATP and substrate Km values, and the inhibitor IC50 values (0.3 1, 3, 9 fold the Km or IC50 values), A preliminary time course experiment in the absence of inhibitor and at the different ATP and substrate concentrations allows the selection of a single endpoint time (10 min) in the linear range of the reaction for the Ki determination experiment. Kinetic parameter estimates: Kinetic parameters were estimated by simultaneous nonlinear least-square regression using [Eq. 1] (competitive inhibitor respect to ATP, random mechanism) using the complete data set (80 points): Vm a • Ka • Kb H- a • Ka • B + a * Kb • A + A • B 4- a • -^ • / • (Kb + - ) Ki j3 wnere A=[ATP], B={Subs.trate], l=[inhibitor], Vm= maximum velocity, Ka, Kb, Ki the dissociation constants of ATP, substrate and inhibitor respectively, a and (3 the cooperativiiy factor between substrate and ATP binding and substrate and inhibitor binding respectively. The compounds of the invention were further tested, in, vitro, to assess the anti-pro'iferative effect onto cell cultures. In vitro cell proliferation assay The human colon cancer ceil line HCT-1 16 was seeded at 5000 cells/cm2 tn 24 wells plate (Costar) using F12 medium (Gibco) supplemented with 10% PCS (EuroClone, Italy) 2 L-gluternine and 1% penicillin/streptomycin and maintained at 37°C, 5% C02 and 96% relative humidity. The following day, plates were treated in duplicates with 5ul of an appropriate dilution of compounds stalling from a 10 mM stock in DMSO. Two untreated control wells were included in each plate. After 72 hours of treatment, medium was withdrawn and cells detached from each welt using 0.5 ml of 0.05% (w/v) Trypsin, 0,02% (w/v) EDTA (Gibcc). Samples were diluted with 9,5 ml of Isoton (Coulter) and counted using a Multisizer 3 cell courier (Beckman Coulter). Data were evaluated as percent of the control wells: % of CTR - (Tieated - B!ank)/(Control - Blank). iC50 values were calculated by LSW/Data Analysis using Microsoft Excel sigmoidal curve fitting. Given the above assays, the compounds of formula (!) of the invention resulted to possess a remarkable protein kinase inhibitory activity, e.g. Aurora-2 inhibitory activity. See, as an example, the following table ! reporting the experimental data of some representative compounds of the invention being tested as Aurora-2 kinase inhibitors (ICso nM) and for their cell antiproliferative effect (ICSO nM). l,'iteres;ingly, these same derivatives were tested in comparison to a structurally very close compound, herewith defined as Reference compound, which is specifically disclosed in the aforementioned PCT/EP03/07531 patent application - see compound No. 421 of example 6. (Figure Removed) Reference Compound: N-benzyl-3-[(4-mcrpho!in-4-y!benzoy!)amino]-1 H-thieno[2,3- Compound (1) [R = 4-(morpho!inyl-4-yl)phenyl; R Compound (2) [R = 4-(morpholinyl-4-yl)phenyl; Rt and R2 together = -CH2-CHr; R3 = H]: 3-[(4-morpho!in-4-ylbenzoyl)amino]-N-(1-phenylcyclopropyl)-1H-thieno[2,3-c]pyra2ole-5-carboxamide; Compound (3) [R = 4-{morpholinyl-4-yl)phenyl; R, = methyl; R2 = H; R3 = F]: N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-morpholin-4-ylben2oyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; Compound (5) [R = 4-(morpholinyl-4-yl)phenyl; R1 = (pyrrolidinyl-lyl)methyl; R2 = R3 = H]: 3-[(4-morpholin-4-ylben2oyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[2,3-c]pyrazole-5-carboxaniide; Compound (29) [R = 4-(4-methyl-piperazinyl-1-yl)phenyl; R, = R2 = methyl; R3 = H]: N-(1rmethyl-1-phenylethyl)-3-{[4-(4-methylpiperazin-1-yl)ben2oyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide; Compound (36) [R = 4-(4-methyl-piperazinyl-1-yl)phenyl; rt = methyl; R2 = R3 = H]: 3-{[4-(4-methylpiper3zin-1-yl)ben2oyl]amino}-N-[(1R)-1-phenylethy]]-1H-thieno[2,3- c]pyrazole-5-carboxamide; Compound (15) [R = 2-thienyl; R, = R2 = methyl; R3 = H]: N-(1-methyl-1-phenylethyl)-3-[(thien-2-ylcarbonyl)amino]-1 H-thieno[2,3-c]pyrazole-5-carboxamide. Table I (Table Removed) Surprisingly, the Aurora-2 inhibitory activity of the compounds of the invention resulted to be constantly and markedly superior that that of the Reference compound. In addition, those same compounds resulted to possess a cell antiproliferative effect significantly superior than that of the Reference compound being tested in the same conditions, From all of the above, the novel compounds of formula (I) of the invention appear to be endowed with a biological profile, considered as a whole, which is unexpectedly superior than! that of the closest compound of WO2004013146and, hence, are particularly advantageous, in therapy, against proliferate disorders associated with an altered Aurora-2 kinase activity, The compounds of the present invention can be administered either as single agents or, alternatively, in combination with known anticancer treatments such as radiation therapy or chemotherapy regimen in combination with cytostatic or cytotoxic agents, antibiotic-type agents, alkylating agents, antimetabolite agents, hormonal agents, immunological agents, interferon-type agents, cyclooxygenase inhibitors (e.g, COX-2 inhibitors), matrixmetalloprotease inhibitors, telomerase inhibitors, tyrosine kinase inhibitors, anti-growth factor receptor agents, anti-HER agents, anti-EGFR agents, anti-angiogenesis agents (e.g, angiogenesis inhibitors), farnesyl transferase inhibitors, ras-raf signal transduction pathway inhibitors, cell cycle inhibitors, other cdks inhibitors, tubulin binding agents, topoisomerase I inhibitors, topoisomerase I! inhibitors, and the like. If formulated as a fixed dose, such combination products employ the compounds of this invention within the dosage range described below and the other pharmaceutically active agent within the approved dosage range. * Compounds of formula (I) may be used sequentially with known anticancer agents when a combination formulation is inappropriate. The compounds of formula (I) of the present invention, suitable for administration to a mammal, e.g., to humans, can be administered by the usual routes and the dosage level depends upon the age, weight, conditions of the patient and administration route. For example, a suitable dosage adopted for oral administration of a compound of formula (I) may range from about 30 to about 500 mg per dose, from 1 to 5 times daily. In general lower doses will be administered when a parental route is employed. Thus, for example, for intravenous administration a dose in the range, for example, 0.5 mg to 30 mg per kg body weight will be generally used. The compounds of the invention can be administered in a variety of dosage forms, e.g., orally, in the form tablets, capsules, sugar or film coated tablets, liquid solutions or suspensions; rectally in the form suppositories; parenterally, e.g., intramuscularly, or through intravenous and/or intratheca! and/or intraspinal injection or infusion. The present invention also includes pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable excipient, which may he a carrier or a diluent. The pharmaceutical compositions containing the compounds of the invention are usually prepared following conventional methods and are administered in a suitable pharmaceutical form. For example, the solid oral forms may contain, together with the active compound, diluents, e.g., lactose, dextrose saccharose, sucrose, cellulose, corn starch or potato starch; lubricants, e.g., silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols; binding agents, e.g., starches, arable gum, gelatine methylcellulose, carboxymethylcellulose or polyvinyl pyrrolidone; disintegrating agents, e.g., starch, alginic acid, alginates or sodium starch glycolate; effervescing mixtures; dyestuffs; sweeteners; wetting agents such as lecithin, polysorbates-, laurylsulphates; and, in general, non-toxic and pharmacologically inactive substances used in pharmaceutical formulations. These pharmaceutical preparations may be manufactured in known manner, for example, by means of mixing, granulating, tabletting, sugar-coating, or film-coating processes. The liquid dispersions for oral administration may be, e.g., syrups, emulsions and suspensions. As an example the syrups may contain, as a carrier, saccharose or saccharose with glycerine and/or mannitol and sorbitol. The suspensions and the emulsions may contain, as examples of carriers, natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethylcellulose, or polyvinyl alcohol. The suspension or solutions for intramuscular injections may contain, together with the active compound, a pharmaceutically acceptable carrier, e.g., sterile water, olive oil, ethyl oleate, glycols, e.g., propylene glycol and, if desired, a suitable amount of lidocaine hydrochloride. The solutions for intravenous injections or infusions may contain, as a carrier, sterile water or preferably they may be in the form of sterile, aqueous, isotonic, saline solutions or they may contain propylene glycol as a carrier. The suppositories may contain, together with the active compound, a pharmaceutically acceptable carrier, e.g., cocoa butter, polyethylene glycol, a polyoxyethylene • sorbitan fatty acid ester surfactant or lecithin. With the aim to better illustrate the present invention, without posing any limitation to it, the following examples are now given. EXPERIMENTAL SECTION The following HPLC method was used in the analysis of the compounds, as specified in the synthetic examples set forth below. As used herein, the term "Rt" refers to the retention 0 time (minutes) for the compound using the HPLC method specified below. LC-MS Method HPLC/MS was performed on a.Waters X Terra RP 18 (4.6 x 50 mm, 3.5 Dm) column using a Waters 2790 HPLC system equipped with a 996 Waters PDA detector and a Micromass mod. ZQ single quadrupole mass spectrometer, equipped with an electrospray ? (ES!) ion source. Mobile phase A was ammonium acetate 5 mM buffer (pH 5.5 with acetic acid / acetonitrile 95:5), and Mobile phase B was water / acetonitrile (5:95). Gradient from 10 to 90% B in 8 minutes, hold 90% B 2 min. UV detection at 220 nm and 254 nm. Flow rate 1 ml/mm. Injection volume 10 u|. Full scan, mass range from 100 to 800 amu. Capillary voltage was 2.5 KV; Source temperature was 120°C; Cone was 10 V. Retention Times (LC-MS Rt) are given in minutes at 220 nm or 254 nm. Mass are given as m/z ratio. Example 1 4-Cyano-5-(methylthio)thiophene-2-carboxylic acid Aqueous sodium hydroxide (20% w/w solution, 9 mL) was added to a solution of ethyl 4-cyano-5-(methylthio)thiophene-2-carboxylate (10 g, 44 mmol) in 1,4-dioxane (100 mL) at 5"C. After stirring for 4 hours at room temperature, water (500 mL) was added to the reaction mixture and the pH was adjusted to about 2.5 by adding 2N solution of aqueous hydrochloric acid. A white solid was separated by filtration, washed with water and dried under vacuum to give 8.5 g of the title compound. LC-MS: Rt 2.4; [M+H]* 200. Example 2 tert-butyl 4-cyano-5-(methylthio)thiophene-2-carboxylate A mixture of 4-cyano-5-(methylthio)thiophene-2-carboxylic acid (2.0 g, 10 mmol), benzyltrimethylamonium chloride (2.25 g, 10 mmol), tertbutyl bromide (54 rnL, 480 mmol) and anhydrous potassium carbonate (36 g, 260 rnmol) in dimethylacetamide (100 ml) was stirred at 60°C for. 6 hours. After cooling, the mixture was diluted with ethyl acetate (400 rnL) and washed with water. Organic layer was dried and evaporated under reduced pressure to give a residue which was purified by chromatography (eluent ethyl acetate / n-hexane 3:1) thus yielding 1,5 g of the title compound. LC-MS' Rt 7.4, [M-HH]* 256. Exampje 3 tert-hiityl 4-cyano-5-(methylsulfonyl)thiophene-2-carboxylate A mixture of tert-butyl 4-cyano-5-(methylthio)thiophene-2-carboxylate (1.4 g, 5,5 mmol) and oxone (14.4 g, 21,5 mmol'i in dirnethylformamide (100 mL) was stirred at room temperature for 16 hours. The reaction mixture was then poured into ice/water (400 ml) and extracted with ethyl acetate. Organic layer was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to afford 1.5 g of the title compound. LC-MS: Rt 6.2; [M.-mf 288. Example 4 l tert-butyl 4-cyano-5-hydrazinothiophene-2-carboxylate A mixture of tert-butyl 4-cyano-5-(methylsulfonyl)thiophene-2-carboxylate (2.0 g, 7.0 rnrno!) and hydrazine hydrate (1.7 mL) in methyl alcohol (30 ml) was stirred at 60°C for 2 hours. The reaction mixture was diluted with ethyl acetate (100 mL) and washed with water. Organic layer was separated, dried over anhydrous sodium sulfate and evaporated. Through . chromatography purification (n-hexane/ethyl acetate 3:2), 1 g of the title compound was thus obtained LC-MS: Rt 5.6, [M+H]* 240. Example 5 tert-butyl 3-amirio-1H-thieno[2,3-c]pyrazole-5-carboxylate A mixture of tert-butyl 4-cyano-5-hydrazinothiophene-2-carboxylate (1.0 g, 4.2 mmol) and Hydrochloric acid (0,7 mL of a 37% solution) in methyl alcohol (15 rnL) was stirred at room temperature for 14 hours, The reaction mixture was diluted with ethyl acetate (50 ml) and washed with an aqueous solution of sodium bicarbonate. Organic layer was separated, dried over anhydrous sodium sulfate and evaporated to afford 0.9 g of the title compound, LC-MS: Rt 4.5; [M+H]+ 240. Example 6 5-tert-butyl 1-ethyl 3-amino-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate A solution of ethyl chlorocarbonate (4.90 ml, 51.7 mmol) in tetrahydrofuran (THF, 60 mL) was slowly added to. a mixture of tert-butyl 3-amino-1H-thieno[2,3-c]pyrazole-5-carboxylate (12.0 g, 50.2 mmol) and diisopropylethylamine (DIEA, 51.5 ml, 301 mmol) in THF (300 mL), maintaining the temperature between -5 and -10°C. The reaction was kept at the same temperature for 5 minutes then allowed to reach room temperature. The obtained mixture was evaporated to dryness under vacuum and the residue extracted with ethyl acetate (AcOEt) and water. The organic layer was separated, dried over sodium sulfate and evaporated to dryness. The resulting raw material was triturated with diethy! ether to give 13.7 g of the title compound as a white solid. LC-MS: Rt 5.6, [M+HJ* 312. Example 7 5-tert-butyl 1-ethyl 3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate Oxalyl chloride (20.2 mL, 231 mmol) was added to a suspension of 4-morpholin-4-ylbenzoic acid (7.98 g, 38.5 mmol) in dry dichloromethane (DCM, 210 mL) and dimethylformamide (DMF, 0.04 mL). After refluxing the mixture for 6.5 hours, volatiles were carefully removed under reduced pressure (taking up the residue three times with toluene). The resulting 4-morpho!in-4-ylbenzoyl chloride hydrochloride was added portion-wise (in about 0.5 hours) to a suspension of 5-tert-butyl 1-ethyl 3-amino-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate (6,0 g, 19.3 mmol) in dry DCM (200 mL) and pyridine (23.2 ml, 289 mmol), under stirring at 5°C. The resulting suspension was stirred for 20 hours at room temperature. 300 mL of DCM and 300 mL of aqueous sodium bicarbonate were then added to the reaction mixture; the organic layer was separated, washed with brine, dried over sodium sulphate and evaporated, Purification by chromatography (DCM / ethyl acetate 7:3) gave 4.05 g of the title compound. LC-MS: Rt 7.2; [M+Hf 501. By operating in an'analogous way and by reacting 5-tert-butyl 1-ethyl 3-arnino-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate with the appropriate acyl chloride derivative, the following compounds were thus prepared: 5-tert-butyl 1-ethyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate; 5-tert-butyl 1-ethyl 3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate; 5-tert-butyl 1-ethyl 3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate; 5-tert-butyl 1-ethyl 3-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate; 5-tert-butyl 1-ethyl 3-(2-furoylamino)-1H-thieno[2,3~c]pyrazole-1,5-dicarboxylate; 5-tert-butyl 1-ethyl 3~({4-[(1-methylpiperidin-4-yI)oxy]benzoyl}arnino)-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate; 5-tert-butyl 1-ethyl 3-({4-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate. Example 8 1-(ethoxycarboiiyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride 5-tert-butyl 1-ethyl 3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylate (4.05 g) was added to a solution of hydrochloric acid in dioxane (88 ml, 4N solution). The resulting mixture was stirred at room temperature for 72 hours. Afterward, volatiles were removed by evaporation under reduced pressure and the residue triturated with diethyl ether, filtered, extensively washed with diethyl ether and dried under vacuum at 40°C to give 3.4 g of the title compound, used in the next step without further purification. LC-MS: Rt 3.1; [M+Hf 445. By operating as above reported and by starting from the suitable intermediate compound, the following derivatives were analogously prepared: 1-(ethoxycarbonyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride; 1-(ethoxycarbonyl)-3-[(4-fluorobenzoyl)amino]-1H-lhieno[2,3-c]pyrazole-5-carboxylic acid; 1-(ethoxycarbonyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid; 1-(ethoxycarbonyl)-3-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-1H-thieno[2,3- c]pyrazole-5-carboxylic acid; 1-(ethoxycarbonyl)-3-(2-furoylamino)-1H-thieno[2,3-c]pyrazoIe-5-carboxy!ic acid; 1-(ethoxycarbonyl)-3-({4-[(1-rnethylpiperidin-4-yl)oxy]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride; 1 -(ethoxycarbonyl)-3-({4-[(4-methylpiperazin-1 -yl)methyl]benzoyl}amino)-1 H- thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride. Example 9 ethyl 5-{[(1-methyl-1-phenylethyl)amino]carbonyl}-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-1-carboxylate A mixture of cumylamine (1.43 g, 10.6 mmol), 2-(1H-benzotriazol-1-yl)-1,1,3,3-15 tetramethyluronium tetrafluoroborate (TBTU, 3.40 g, 10,6 mmol), 1-(ethoxycarbonyl)-3-[(4-morpholin-4~y!benzoyl)amino]-1H-thieno[2,3-c]pyra2ole-5-carboxylic acid hydrochloride (3.40 mg, 7.07 mmol) and N,N'-diisopropylethylamine (12.1 ml, 7.07 mmol) in 80 ml of dimethylforrnamide was stirred at room temperature for 20 hours. Afterward the reaction mixture was diluted with water and extracted with dichloromethane. Volatiles were removed by 20 evaporation under reduced pressure and the residue was triturated with ethyl acetate, filtered, extensively washed with diethyl ether and dried under vacuum at 40°C, to give 3.7 g ofthe title compound, used in the next step without further purification. LOMS: Rt 6.8; [M+Hf 562. By operating as above reported and by starting from the suitable intermediate derivative, the following compounds were analogously prepared: ethyl 3-[(4-morpholin-4-ylbenzoyl)amino]-5-{[(1-phenylcyclopropy!)amino]carbonyl}-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 5-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-3-[(4-morpholin-4-y|ben2oyl)amino]-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-[(4-morpholin-4-ylbenzoyl)amino]-5-({[(1R)-1-phenylpropyl]amino}carbonyl)- 1H-thi9no[2,3-c)pyrazole-1-carboxylate; ethyl 3-[(4-morpholin-4-ylbenzoyl)amino]-5-({[(1S)-1-phenyl-2-pyrroiidin-1-y!sthy!]amino}carbonyl)-1H-thieno[2,3-c]pyr3zoie-1-carboxylate; ethyl 3-[{4-morpholin-4-ylbenzoyl)amino]-5-({[(1S)-2-morpholin-4-yl-1-phenylethyl]amino}carbonyl)-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-[(4-fluoroben2oyl)amino]-5-{[(1-phenylcyclopropyl)amino]carbonyl}-1H-thieno[2,3-c]pyrazole-1-carboxy!ate; ethyl 3-[(4-fluorobenzoyl)amino]-5-{[(1-methyl-1-phenylethyl)amino]carbonyl}-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-{(4~fluorobenzoyl)amino]-5-({[(1 R)-1-phenylpropyl]amino}carbonyl)-1 H- thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-[(4-fluorobenzoyl)amino]-5-({[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]amirK)}carbonyl)-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-[(4-fluorobenzoyl)amino]-5-({[(1 R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-1 H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-[(4-fluorobenzoyl)amino]-5-({[(1S)-2-morpholin-4-yl-1-phenylethyl]amino}carbonyl)-1H~thieno[2,3-c]pyrazole-1-carboxylate; ethyl 5-{[(1-ethyl-1-phenylpropyl)amino]carbonyl}-3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-[(4-fluorobenzoyl)amino]-5-{[(1 -phenylcyclopentyl)amino]carbonyl}-1 H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 5-({[(1S)-2-morpholin-4-yl-1-phenylethyl]amino}carbonyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 5-{[{1-rnethyl-1-phenylethyl)amino]carbonyl}-3-[(thien-2-ylcarbonyl)amino]-lH-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 5-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-3-[(thien-2-ylcarbpnyl)amino]-1 H-thieno[2,3-c]pyrazoie-1-carboxylate; ethyl 5-{[(1-phenylcyclopropyl)amino]carbonyl}-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-1-carboxylate; 1-(ethoxycarbonyl)-3-({4-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)-1H- . thieno[2,3-c)pyrazole-5-carboxylic acid hydrochloride; ethyl 5-({[(1R)-1-phenylpropyi]amino)carbonyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 5-{[( 1-rnethyl-1-phenylethyl)amino]carbonyl}-3-{[(1 -methyl-1 H-pyrrol-2-yl)carbonyl)amino}-1 H-thieno[2,3-c]pyrazole-1-carboxylate; ethy! 3-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-5-{[(1-pherylcyclopropyl)amino]carbonyl}-1 H-thieno[2,3-c]pyrazole-1 -carboxylate; ethyl 3-(2-furoylarnino)-5-{[(1-phenylcyclopropyl)amino]carbonyl}-1H-thieno[2l3-c]pyrazole-1-carboxylate; ethyl 3-(2-furoylamino)-5-{[(1-methyl-1-phenylethyl)amino]carbonyl}-1H-thieno[2,3-c]pyrazole-1-carbo.xylaie; ethyl 5-{f(1-rnethyl-1-phenylethyl).amino]carbonyl}-3-({4-[(1-methylpiperidin-4-yl)oxy]benzoyl}amino)-lH-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-({4-[(1-methylpiperidin-4-yl)oxy]benzoyl}amino)-5-{[(1-phenylcyclopropyl)amino]carbonyl}-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 5-{[(1-methyl-1-phenylethyl)amino]carbonyl}-3-({4-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-1-carboxylate; ethyl 3-({4-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)-5-{[(1-phenylcyclopropyl)amino]carbonyl}-lH-thieno[2,3-c]pyra2ole-1-carboxylate. Example 10 N-{1-methyl-1-phenylethyl)-3-[(4-rnorpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide (1) A suspension of ethyl 5-{[(1-methyl-1-phenylethyl)amino]carboriyl}-3-[(4-rnorpholin-4-ylbenzoyl)amino]-1H~thieno[2,3-c]pyrazole-1-carboxylate (3.71 g, 6.6 rnmol) in methanol (MeOH, 70 ml) and triethylamine (TEA, 7 ml) was stirred at 70° C for 5 hours. After evaporation of the solvent under reduced pressure, the residue was taken up with DCM and washed with water. The organic layer was separated, dried over sodium sulfate and evaporated. Purification by chromatography (DCM / MeOH 47:3) gave 2.8 g of the title compound. LC-MS: Rt 5.70; [M+Hf 490. By operating as above reported and by starting from the suitable intermediate derivative, the following compounds were analogously prepared: 3-[(4-morpholin-4-ylbenzoyl)amino]-N-(1-phenylcyclopropyl)-1H-thieno[2,3- c]pyrazole-5-carboxamide; LC-MS: Rt 5.5; [M+Hf'488; N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3- c]pyrazole-5-carboxamide; LC-MS: Rt 5.6; [M+H]+ 494; 3-[(4-morpholin-4-ylben2oyl)amino]-N-[(1R)-1-phenylpropyl]-1H-thieno[2,3- c]pyrazole-5-carboxamide; LC-MS: Rt 5.8; (M+H]+ 490; 3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H- thieno[2.3-c)pyrazo!e-5-carboxamide; LC-MS: Rt4.3; [M+H]* 545; 6} 3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; LC-MS: Rt 5; [M+H]+561; 3-[(4-f!uorobenzoyl)amino]-N-(1-phenylcyclopropyl)-1H-thieno[2,3-c]pyrazo!e-5- carboxamide; LC-MS: Rt 5.7; [M+H]+ 421; 3-[(4-fluorobenzoyl)amino]-N-(1-methyl-1-phenylethyl)-1H-thi.eno[2,3-c]pyrazole-5- carboxamide; LC-MS: Rt 6.1; [M+Hf 423; 3-[(4-fluorobenzqyl)amino]-N-[(1R)-1-phenylpropyl]-1H-thieno[2,3-c]pyrazole-5- carboxamide; LC-MS: Rt6.1; [M+H]+423; 10) 3-[(4-fluorobenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[2,3- c]pyrazole-5-carboxamide; LC-MS: Rt 4.4; [M+Hf 478; 11) 3-[(4-fluprobenzoyl)arnino]-N-[(1R)-1-(4-fluorophenyl)ethyl]-1H-thieno[2,3- c]pyrazo!e-5-carboxamide; LC-MS: Rt 5.9; [M+H]*.427; 3-[(4-fluorobenzoyl)amino]-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]-1H- thieno[2,3~c]pyrazole-5-carboxamide; LC-MS: Rt 5.3; [M+H]+494; N-(1-ethyl-1-pHenylpropyl)-3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole- 5-carboxarnide; LC-MS: Rt 6.7; [M+Hf 451; 3-[(4-fluorobenzoyl)amino]-N-(1-phenylcyclopentyl)-1H-thieno[2,3-c]pyrazole-5- carboxamide; LC-MS: Ri 6.5; [M+H]* 449; N-[(1S)-2-morpholin-4-yl-1-phenylethyl]-3-[(thien-2-ylcarbonyl)amino]-1H- thieno[2,3-c]pyrazole-5-carboxamide; LC-MS: RI4.55; [M+H]+482; N-(1-methyl-1-phenylethyl)-3"[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3- c]pyrazole-5-carboxamide; LC-MS: Rt 5.64; [M+H]+411; N-[(1R)-1-(4-fluorophenyl)ethyi]-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3- c]pyrazole-5-carboxamide; LC-MS: Rt 5.63; [M+H]+415; N-(1-phenylcyclopropyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole- 5-carboxamide; LC-MS: Rt 5.43; [M+H]* 409; 18) N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-3-t(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; LC-MS: Rt 3.83; [M+HJ* 466; 20) N-[(1R)-1-phenylpropyl]-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole- 5-carboxamide; LC-MS: Rt 5.81; [M+H]* 411; N-(1-methyl-1-phenylethyl)-3-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-1H- thieno[2,3-c]pyrazole-5-carboxamide; LC-MS: Rt 5.84; [M+H]+408; 3-{[(1-rnethyl-1H-pyrrol-2-yl)carbonyl]amino}-N-(1-phenylcyclopropyl)-1H- thieno[2,3-c)pyrazole-5-carboxamide; LC-MS: Rt 5.57; [M+H]+406; 3-(2-furoylamino)-N-(1-phenylcyc]opropyl)-1H-thieno[2,3-c]pyrazole-5- carboxamide LC-MS: Rt 5.04; [M-t-H]+ 393; 3-(2-furoylamino)-N-(1-methyl-1-phenylethyl)-1H-thieno[2,3-c]pyrazoie-5- carboxamide LC-MS: Rt 5.35; [M+Hf 395; N-(1-methyl-1-phenylethyl)-3-({4-[(1-methylpiperidin-4-yl)oxy]benzoy!}amino)-1H- thieno[2,3-c]pyrazole-5-carboxamide; LC-MS: Rt 3.76; [M+H]+ 518; 2.6) 3-({4-[(1 -methylpiperidin-4-yl)oxy]benzoyl}amino)-N-(1 -phenylcyclopropyi)-1 H-thieno[2,3-c]pyrazole-5-carboxamide LC-MS: Rt 3.75; [M+Hf 516; N-(1-methyl-1-phenylethyl)-3-({4-[(4-methylpiperazin-1-yl)methyl)benzoyl}amino)- 1H~thieno[2,3-.c]pyrazole-5-carboxamide;. LC-MS: Rt3.8; [M+H]+517; 3-({4-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)-N-(1-phenylcyclopropyl)- • 1H-thieno[2,3-c]pyrazole-5-carboxamide. LC-MS: Rt 3.58; [M+H]+ 515. Example 11 tert-butyl 1-[4-(4-rnethylpiperazin-1-yl)benzoyl]-3-{[4-(4-rnethylpiperazin-1- yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylate Oxalyl chloride. (11 mL, 127 rnmol) was added to a suspension of 4-(4- methylpipera2in-1-yl)benzoic acid (4.62 g, 21 mmol) in DCM (150 mL) and DMF (0.15 mL). After refluxing the mixture for 6.5 hours, volatiles were carefully removed under reduced pressure (taking up the residue three times with toluene). The resulting 4-(4-methylpiperazin~1-yl)benzoyl chloride hydrochloride was added portion-wise (in about 6 hours) to a suspension of tert-butyl 3-amino-1H-thieno[2,3-c]pyrazole-5-carboxylate (0,62 g, 2.6 rnmol) in dry DCM (80 mL) and pyridine (3.1 mL, 39 mmol) under stirring at 5°C. The resulting suspension was stirred for 72 hours at room temperature. 300 mL • of aqueous sodium bicarbonate were then added to the reaction mixture and the organic layer was separated, washed with brine, dried over sodium sulphate and evaporated. The residue (6.2 g), a mixture of the title compound, of 4-(4-methylpiperazinin-1-yl)benzoic acid and of 4-(4-rnethylpiperazinin-1-yl)benzoic anhydride, was used in the following example without purification. Example 12 tert-butyl 3-{[4-(4-methyipiperazin-1~yl)benzoyljamino}-1M-tnieno[2,3-c]pyrazo!e-5-carboxylate The mixture obtained as described in Example 11 (6.2 g) was treated with MeOH (45 ml) and TEA (5 ml) and stirred at room temperature for 16 hours. Then, the solution was evaporated and the residue was purified by flash chromatography over silica gel (DCM / MeOH / ammonia 7N solution in methyl alcohol 94:5:1) to afford the title compound as a solid (0.500 g). LC-MS: R14.72, [M+Hf442. Example 13 3-{[4-(4-methylpiperazin-1-yl)benzoylJamino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride A mixture of tert-butyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylate (0.50 g, 1.1 mrnol) in hydrochloric'acid 4M in dioxane (15 ml) was stirred for 16 hours at room temperature. Afterward, volatiles were removed by evaporation under reduced pressure and the residue was triturated with ethyl ether to give 0.496 g of the title compound as a white solid. LC-MS: Rt (m) 1.35, [M+Hf 386. Example 14 N-(1-methyl-1-phenylethyl)-3~{[4-(4-methylpipera2in-1-yl)benzoyl]amino}-1H-thienof2,3-c]pyrazole-5-carboxamide (29) To an ice-cooled suspension of 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-lH-thieno[2,3-c]pyrazole-5-carboxylic acid (113 mg, 0.27 tnmol) and N,N'-diisopropylethylamine (2.1 mmol, 0.38 ml) in 3 ml of N,N-dimethylformamide were added, dropwise, 0.154 ml of ethylchloroformate (1.6 mmol). After 20 minutes, 1-methyl-1-phenyl-ethylamine (0.302 ml, 2,1 rnrnoi) was added to the obtained solution and the reaction mixture was allowed to warm to room temperature. After 16 hours, the reaction mixture was diluted with dichlorornethane and washed with an aqueous solution of sodium bicarbonate. After solvent evaporation the residue was taken up with methyl alcohol (9 ml) and triethylamine (1 ml) and stirred at 40°C for 2 hours. The reaction mixture was then evaporated to dryness to give an oil, which was purified by flash chromatography over silica gel, using dichloromethane/methanol/ ammonia 7N solution in methyl alcohol (93:6:1) as eluent, to afford the title compound as a white solid (61 mg). LC-MS: Rt 4.14, [M+H]+ 489. By operating as above reported and by starting from the suitable intermediate derivative, the following compounds were analogously prepared: 30) 3-{[4-(4-methylpipera2in-1-yl)benzoyl]amino}-N-[(1R)-1-phenylpropy!]-1H- thieno[2,3-c]pyrazole-5-carboxamide LC-MS: Rt 4.54; [M+H]* 503; 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-N-[(1S)-2-morpholin-4-yl-1- phenylethyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide LC-MS: R13.14; [M+Hf 574; 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-N-[(1S)-1-phenyl-2-pyrrolidin-1- ylethyl]~1H-thieno[2,3-c]pyrazole-5-carboxamide LC-MS: 2.56; [M+Hf 558; N-(1-ethyl-1-phenylpropyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]arnino}-1H- thieno[2,3-c]pyrazole-5-carboxamide LC-MS: Rt 4.4; [M+H]+531; 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-N-(1-phenylcyclopentyl)-1H- thieno[2,3-c]pyrazole-5-carboxamide LC-MS: Rt 5.75; [M+H]* 529; 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-N-(1-phenylcyclopropyl)-1H- thieno[2,3-c]pyrazole-5-carboxamide LC-MS: Rt 3.47; [M+H]+501; 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}"N-[(1 R)-1-phenylethyl]-1 H- thieno[2,3-c]pyrazole-5-carboxamide LC-MS: Rt 4,54; [M+Hf 489. Example 15 5-tert-butyl 1-ethyl 3-[(4-chloromethyl-benzoyl)amino]-1 H-thieno[2,3-c]pyrazo!e-1,5-dicarboxylate 4-Chloromethylbenzoyl chloride (5.42 g 28.7 mmol) was added to a suspension of tert-butyl 3-amino-1H-thieno[2,3-c]pyrazole-5-carboxylate (5.94 g, 19,1. mmol) in dry DCM (150 mL) and 2,4,6-collidine (6.94 g, 57.3 mmol) under stirring at 20°C, The resulting suspension was stirred for 3 hours at room temperature. 300 mL of aqueous sodium bicarbonate were then added to the reaction mixture and the organic layer was separated, washed with brine, dried over sodium sulphate and evaporated. The residue was triturated with hexane, filtered and dried at 40°C under vacuum to give 8,3 g of the title compound. LC-MS: Rt, [M+H]+ 464. By operating as above reported and by starting from the suitable intermediate derivative, the following compounds were analogously prepared: ethyl 3-[(4-chlororriethyl-benzoyl)amino]-5-{[(1-phenylcyclopropyl)amino]carbonyl}-1H-thieno[2,3-c]pyrazole-1-car.boxylate Example 16 1-(ethoxycarbonyl)-3-[(4-chloromethyl-ben2oyl)amirto]-1H-thieno[2,3-c]pyrazoie-5-carboxyiic acid 5-tert-butyl 1-ethyl 3-[(4-chloromethyl-benzoyl)amino]-1H-thieno[2,3-c]pyrazole-1,5-dicarboxylale (8,2 g) was added to a solution of hydrochloric acid in dioxane (83 ml, 4N solution). The resulting mixture was stirred at 50°C for 2 hours. Afterward, volatiles were removed by evaporation under reduced pressure and the residue triturated with diethyl ether, filtered, extensively washed with diethyl ether and dried under vacuum at 40°C to give 5.7 g of the title compound, used in the next step without further purification. LC-MS: Rt; [M+H]' 408. Example 17 ethyl 5-{[(1-methyl-1-phenylethyl)amino]carbonyl}-3-[(4-chloromethyl-benzoyl)arnino]-1H~thierio[2,3-c]pyrazole-1-carboxylate A mixture of cumylamine (1.43 g, 10.6 mmol), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU, 3.40 g, 10.6 mmol), 1-(ethoxycarbonyl)-3-[(4-chloromethyl-benzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic (2.88 mg, 7,07 mmol) and N,N'-diisopropylethylarnine (18.2 ml, 10.6 rnmol) in 150 ml of dichloromethane was stirred at room temperature for 20 hours. Afterward the reaction mixture was washed with aqueous hydrochloric acid 2N and brine, and dried over sodium sulphate. Volatiles were removed by evaporation under reduced pressure and the residue was triturated with di-ethyl ether, filtered, extensively washed with diethyl ether and dried under vacuum at 40°C, to give 3.3 g of the title compound, used in the next step without further purification. LC-MS: Rt; [M+H]'408. Example 18 3-(4-Pyrrolidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methy!-1-phenyl~ethyl)-amide (37) Pirrolidine (1.81 ml, 21.8 mmol), was added to a suspension of ethyl 5-{[(1-methyl-1-phenylethyl)amino]carbonyl)-3-[(4-chloromethyl-benzoyl)amino]-1H-thieno[2l3-c]pyrazole-1-carboxylate (3.80 mg, 7.25 mmol) in 100 ml of dry ethanol. And the resulting mixture was stirred at 79"C for 1 hour. Afterward the volatiles were removed by evaporation under reduced pressure and the residue was purified by chromatography over silica gel (eluant dichloromethane / methyl alcohol / aqueous ammonia 92:8:01) to give 1.2 g of the title compound. LC-MS: Rt3.8; [M+H]*488. By operating as above reported and by starting from the suitable intermediate derivative, the following compounds were analogously prepared: 38) 3-{4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-methy!-1-phenyl-ethyl)-amide;. LC-MS: Rt 4.4; [M+H]* 504. 39) 3-(4-Piperidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid(1-methyl-1-phenyl-ethyl)-amide; LC-MS: Rt4.9; [M+H]* 502. 40) 3-[4-(lsopropylamino-methyl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-methyl-1-phenyl-ethyl)-amide: Rt4.7; [M+Hj*476. 41) 3-[4-(1,1 -Dioxo-1 -thiomorpholin-4-ylmethyl)-benzoylaminoj-1 H-thieno[2,3- c]pyrazole-5-carboxylic acid(1-methyl-1-phenyl-ethyl)-amide; Rt5.1; [M+H]*.552. 42) 3-(4-Morpholin-4-ylmethy l-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(3-fluoro-phenyl)-1-methyl-ethyl]-amide; Rt 5.4; [M+H]* 522. 43) 3-(4-Morpholin-4-yImethyl-benzoylamino)-1H~thieno[2,3-c]pyrazole~5- carboxylic acid [1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]+522. 44) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(4-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]+522. 4-{4-[5-(1-Methyl-1-phenyl-ethylcarbamoyl)-1H-thieno[2,3-c]pyrazol-3- ylcarbamoyl]-benzyl}-piperazine-1-carboxylic acid iert-butyl ester; Rt6.6; [M+H]* 603. 3-[4-(4-Fluoro-piperidin-1-ylmethyl)-benzoylamino]-1H-thieno[2,3-cpyrazole-5- carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; Rt 5.5; [M+H]* 520. 3-(4-Piperazin-1-ylrnethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1~methyl-1-phenyl-ethyl)-amide; Rt 4.6; [M+H]* 503. 3-(4-lmidazol-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; Rt 4.9; [M+H]* 485. 3-(4-Thiazolidin-3-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; Rt6,3; [M+H]*506. 3-(4-Pyrrblidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(3-fluoro-phenyl)-1-methyl-ethyl]-amide; Rt 4.3; [M+H]+506, 3-(4-Piperidin-1-ylmethyl-benzoy!amino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(3-fluoro-phenyl)-1-methyl-ethyi]-amide; Rt 4,5; [M+H]* 520. 52) 3-(4-Piperidin-1-ylmethyl-ben2oylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid f1-(2-fluoro-phenyl)-1-methy)-ethyl]-amide; [M+H]1"520. 53) 3-(4-Azetidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyra2ole-5-carboxylic acid (1 -methyl- 1-phenyl-ethyl)-amide; Rt 3.7; [M+H]*474. 54) 3-(4-A2etidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+Hf 492. 55) 3-(4-Azetidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]+492. 56) 3-(4-A2etidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(4-fluoio-phenyl)-1-methyl-ethyl]-amide; [M+H]*492. 57) 3-[4-(4-tert-Butyl-piperazin-1-ylmethyl)-benzoylamino]-1H-thieno[2,3- c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; Rt4.4; [M+Hf 559, 58) 3-(4-Pyrrolidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]py,razole~5- carboxylic acid [1-(4-fluoro-phenyl)-1-methyl-ethyl]-amide; Rt 4.4; tM+H]+506. 3-(4-Piperidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazo!e-5- carboxylic acid (1-(4-fluoro-phenyl)"1-methyl-ethyl]-amide; Rt 4.6; [M+H]+520. 3-Phenylacetylamino-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1- phenyl-ethyl)-amide; [M+H]*448. 3-(4-Dimethylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; [M+H]4 462. 3-(4-Cyclopropylaminomethyl-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-rnethyl-1-phenyl-ethyl)-amide; Rt4.1; [M+H]*474. 3-(4-Cyciobutylaminomethyl-ben2oylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-rnethyl-1-phenyl-ethyl)-amide; Rt4.3; [M+H]+488. 3-{4-[(lsopropyl-methyl-amino)-methyl]-benzoylamino}-1H-thieno[2,3- c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; R14.3; [M+H]*488, 65,i 3-(4-Cyclopentylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; Rt 4,5; [M+Hf 502. 66) 3-{4-[(Diisopropylamino)-methyl]-benzoylamino}-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; Rt5.1; [M+H]*518. 67; 3-(4-Aminomethyl-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1-pheny!-elhyl)-amide; [M+H]T434. 68) 3-(4-Pyrrolidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxyiic ncid [1-(2-fluoro-phenyl)-1-methyl-ethyl]-arnide; [M+H]*506. 69) 3-(4-Pyrrolidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(2-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 518. 70) 3-(4-Pyrrolidin-1 -ylmethyl-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(3-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 518. 71) 3-(4-Pyrrolidin-1-y]methyl-benzoylamino)-1H-thieno[2,3-cjpyrazole-5- carboxylic acid [1-(4-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 518. 72) 3-(4-Piperidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(4-methoxy-pheny'l)-1-methyl-ethyl)-amide; [M+H]* 532 73) 3-(4-Piperidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxyiic acid [1-(3-methoxy-phenyl)-1.-methyl-ethyl]-amide; [M+H]* 532. 74) 3-(4-Piperidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole~5- carboxylic acid [1-(2-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 532. 75) 3-(4-Azetidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 504. 76) 3-(4-Azetidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-methoxy~phenyl)-1-methyl-ethyl]-amide; [M+H]* 504 77) 3-(4-Azetidin-1-ylmethyl-benzoylamino)-1H-thieno[2,3~c]pyrazole-5-carboxylic acid [1-(4-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+Hf 504. 78) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(4-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 534. 3-(4-Morpholin-4-ylmethyl-benzoylamino)-lH-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(3-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 534. 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(2-methoxy-phenyl)-1-methyl-ethyl]-arnide; [M+H-]* 534 3-[4-{4-Methyl-piperazin-1-yl)-benzoylamino]-lH-thienb[2,3-c]pyra2ole-5- carboxylic acid [1-methyl-1-(2-methoxy-phenyl)-ethyl]-amide; [M+H]* 547. 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyra2ole-5- carboxylic acid [1-methyl-1-(3-methoxy-phenyl)-ethyl]-amide; [M+H]* 547. 3-[4-(4-Methy!-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-methyl-1-(4-methoxy-phenyl)-ethyl]-amide; [M+H]* 547. 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-methyl-1-(2-fluoro-phenyl)-ethyl]-amide; [M+H]* 535. 3-[4-(4-Methyl-piperazin-1 -yl)-benzoylamino]-1 H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-methyl-1-(3-fluoro-phenyl)-ethyl]-amide; [M+H]* 535. 86) 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-1-(4-fluoro-phenyl)-ethyl]-amide; [M+H]+ 535. 37) 3-({4-[(1-methylpiperidin-4-yl)oxy]benzoyl}amino)-1H-thieno[2,3-c]pyra20le-5-carboxylic acid [1-methyl-1-(2-fluoro-phenyl)-ethyl]-amide; [M+Hf 536. 88) 3-({4-[(1-methylpiperidin-4-y!)oxy]benzoyl}amino)-1H-thieno(2,3-c]pyrazole-5- carboxylic acid [1-methyl-1-(3-fluoro-phenyl)-ethyl]-amide; [M+Hf 536. 89) 3-({4-[(1-methylpiperidin-4~yl)o.xy]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-methyl-1-(4-fluoro-phenyl)-ethyl]-amide; [M+Hf 536. 3-({4-[(1-methylpiperidin-4-yl)oxy]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-methyl-1-(4.-methoxy-phenyl)-ethy!]-amide; [M+H]* 548. 3-({4-[(1-methy_lpiperidin-4-yl)oxy]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-methyl-1-(3-methoxy-phenyl)-ethy!]-amide; [M+H]* 548. 3-({4-[(1-methylpiperidin-4-yl)oxy]benzoyl}amino)-1H-thienq[2,3-c]pyrazole-5- carbo.xylic acid [1-methyl-1-(2-rnethoxy-p'henyl)-ethyl]-amide; [M+H]+ 548. 3-(4-Cyclopropylaminornethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid 1-(2-fluoro-phenyl)-1-methyl-etbyl]-amide; [M+H]* 492. 3-(4-Cyclopropylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5- carboxylic acid 1-(2-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 504. 3-[4-(lsopropylamino-methyi)-benzoylamino]-1H-thieno(2l3-c]pyrazole-5- carboxylic acid 1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]* 494. -3-[4-(lsopropylamino-methyl)-benzoylamino]-1H-thieno[2,3-c]pyra2ole-5- carboxylic acid 1-(2-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+Hf 506. 3-(4-Azepan-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxy!ic acid (1-methyl-1-phenyl-ethyl)-amide; R14.6; [M+H]+516. 3-(4-Azepan-1-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]*534. 3-(4-Pyrazo!-1 -ylmethyl-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; Rt 5.0; [M+H]*485. Example 19 By operating as above reported in Example 10, the following compounds were analogously prepared by starting from the suitable intermediate derivatives: 100) 3-(4-methoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyl-1 -phenyl-ethyl)-amide; [M+Hf 435. 101) 3-(3-methoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyl-1-pheny!-ethyl)-amide; [M+H]+ 435. 102) 3-(2-methoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyl-1-phenyl-ethyl)-arnide; [M+Hf 435. 103) 3-(3-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyra2ole-5-carbo.xy!ic acid (1-methyl-1-phenyl-ethyl)-amide; [M+H]+ 490. 104) 3-[4-(4-Methyl-piperazm-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-' carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; [M+H]+p503. 105) 3-(4-Dimethylamino-benzoy!amino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (l-methyM-phenyl-ethyl)-amide; [M+H]+ 448. 106) 3-[(Furan-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyl-1-phenyl-ethyl)-amide; [M+H]+ 395. 107) 3-!(Thiophene-3-carbonyl)-amino]-1 H-thieno[2,3-c]pyrazoler5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; [M+Hf 411. 108) 3-[(1-Methyl-1H-pyrrole-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5- carboxyiic acid (1-rne(hyl-1-phenyl-ethyl)-amide; (M+H]+ 408. 109) 3-[(1.-Methyl-1 H-pyrazole-3-carbanyl)-amino]-1 H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; [M+H]* 409. 110) 3-[(1-Methyl-1H-pyrazoie-5-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-methy!-1-phenyl-ethy!)-amide; [M+H]+ 409. 3-[(Pyridine-2-carbonyi)-amino)-1H-thieno[2,3-c]pyrazole-5-carboxy!ic acid (1- methyl-1-phenyl-ethyl)-amide; [M+H]+ 406. 3-[(Pyridine-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyl-1-phenyl~ethyl)-amide; [M+H]" 406. 3-[(Pyridine-4-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyi-1-phenyl-ethyl)-amide; [M+H]+ 406. 3-(4-Chloro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyl-1-phenyl-elhyl)-amide; [IVH-H]" 439. -(4-Phenoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyl-1-phenyl-ethyl)-amide; [M+H]+ 497. 3-(4-Morpho!in-4-yl-benzoylammo)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-f2-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]+ 520. 3-(4-Morpholin-4-yl-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid [1 -(4-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 520. 118) 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid[1-(2-methoxy-phenyl)-1-methyl-athyl]-amide; [M+H]+ 533. 119) 3-[4-(4-Methyl-piperazin-1 -yl)-benzoylamino]-1 H-thieno[2,3-c]pyrazole-5- carboxylic acid[1-(3-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+Hf 533. 120) 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyra2ole-5- carboxylic acid[1-(4-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]+ 533. 121) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-e!hyl-1 pheny!-propyl)-amide; R16.5; [M+Hf 439. 122) 3-!(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-phenyl-cyclopentyl)-amide;Rt6.3; [M+H]* 437. 123) 3-[(Thiophene-2-carbonyl)-arnino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide;Rt 5.7; [M+H]+ 429. 124) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c)pyrazole-5-carboxylic acid [1-(3-fluoro-phenyl)-1-methyl-ethyl]-amide;Rt 5.6; [M+H]* 429. 125) 3-(4-Trifluoromelhoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-2-morpholin-4-y!-1-phenyl-ethyl)-amide;Rt 5,61; [M+H]* 560. 126) 3-[4-(2-Dimethylamino-ethoxy)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]+ 510. 127) 3-[4-(2-Dimethylamino-ethoxy)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; [M+H]+ 492. 3-(4-Fluoro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-1- phenyl-2-piperidin-1-y!-ethyl)-amide;Rt 4.7; [M+H]* 492. 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-ethyl-1-pheny!-propyl)-amide;Rt 6.4;518. 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-1-phenyl-2-piperidin-1-yl-ethyl)-amide;Rt 4.4; [M+H]+ 480. 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyra2ole-5-carboxylic acid (1-phenyi-cyclopentyl)-amide;Rt 6.1; [M+H]* 516. 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid[1-(3-chloro-phenyl)-1-methyl-ethyl)-amide;Rt 4.8; [M+H]+ 537. 3-(4-Fluoro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3- chloro-p'nenyl)-1-methyl-ethyl]-amide;Rt 6.3; [M+H]" 457. 3-(4-Methoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- phenyl-cyclopropyl)-amide;Rt 5.5; [M-rHf 433, 135) 3-(4-Trifiuoromethoxy-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-phenyl-cyclopropyl)-amide;Rt 6.5; [M+H]* 487. 136) 3-[(6-Morpholin-4-yl-pyridine-3-carbonyl)-amino]-1 H-thieno[2,3-c]pyrazole-5- carboxylic acid (1~methyl-1-phenyl-ethyl)-amide; Rt 5.2 [M+H]* 491, 137) 3-(4-Morpholin-4-yl-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5-carboxylic. acid ((S)-1-methyl-2-morpholin-4-yl-1-phenyi-ethyl)-amide; Rt 5.5 [M+H]* 575. 138) 3-(4-Morpholin-4-yl-benzoy!amino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyi-1-pyridin-4-yl-ethyl)-amide; Rt 4.4 [M+H]* 491. 139) 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(4-fluoro-phenyl)-1-rnethyl-ethyl]-amide;Rt4.3; [M+H]* 521. 140) 3-(4-Morpholin-4-yl~benzoylarnino)-1 H-thieno(2,3-c]pyrazole-5-carboxylic acid [1-(3-methoxy-phenyl)-1-methyl-ethyl]-amide;Rt 5.7; [M+H]+ 520. 141) 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3.-c]pyrazole-5- carboxylic acid[1-(2-fluoro:phenyl)-1-methyl-ethyl]-amide;Rt 4.4; [M+H]+ 521. 142) 3-[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-(3-fluoro-phenyl)-1-methyl-ethyl]-amide;Rt 4.5; [M+H]* 521. 143) 3-(4-Methanesulfonyl'benzoylamino)-1H-thieno[2,3-clpyrazole-5-carbQxylic acid(1-methyl-1-phenyl-ethyl)-amide;Rt 5.4; [M+H]* 483, 144) 3-[4-(1,1-Dioxo-thiomorpholin-4-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; Rt 4.9 [M+H]+ 538. 145) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-1-(3-pyrrolidin-1-yl-phenyl)-ethyl]-amide;Rt6.7;[M+Hr 559. 3--[4-(4-Methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid [1-methyl-1-(3-pyrro!idin-1-yl-phenyl)-ethyl]-amide; Rt 5.2; [M+H]+ 572. 3-(4-Morpholin-4-yl-benzoylarnino)-1 H-thieno[2,3-c]pyrazole-5-carboxy!ic acid [1-(3-methanesulfonyl-phenyl)-1-methyl-ethyl]-amide; Rt 4.6 [M+Hf 568, 3-(4-Morpholin-4-yl-benzoylamino)-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide;Rt5.8; [M+Hf 508. 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-fluoro-phenyl)-1-methyl-ethyl]-amide;Rt 5.9; [M+Hf 508. 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2l3-c]pyrazole-5-carboxylic acid [1~;4-fluoro-phenyl)-1-methyl-ethyl]-amide;Rt 5.9; [M+Hf 508. 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxyiic acid [1-(4-fluoro-phenyl)-1-methyl-ethyl]-amide;Rt 5.7; [M+H]* 429. 152) 3-[(Thiophene-2-carbonyl)-amino]-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-{2-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 441. 153) 3-[(Thiophene-2-carbonyl)-amino]-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 441. 154) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(4-rnethoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 441. 155) 3-[(Furan-2-carbony!)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxy]ic acid 1-^2- fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]* 413. 156) 3-[(Furan-2-carbonyl)-amino]-lH-thieno[2,3-c]pyrazole-5-carboxylic acid 1-(3- fluoro-phenyl)-1-methyl-ethyl]-amide: [M+H]'413. 157) 3-[(Furan-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 1-(4- fluoro-phenyl)-1-methyl-elhyl]-amide; [M+H]' 413. 158) 3-[(Furan-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-cgrboxylic acid 1-(2- methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 413, 159) 3-[(1-Methyl-1H-pyra2ole-5-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid 1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]* 427. 160) 3-[(1-Methyl-1H-pyra2ole-5-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid 1-(2-methoxy-phenylj-1-methyl-ethyl]-amide; (M+H]* 439. 161) 3-[( 1 -Methyl-1 H-pyrazole-5-carbonyl)-amino]-1 H-thieno[2,3-c]pyrazole-5- carboxylic acid 1-(4-fluoro-phenyl)-1-rnethyl-ethyl]-amide; [M+H]* 427. 162) 3-[(1-Methyl-1H-pyrazole-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid 1-(2-fluoro-phenyl)-1-methyl-ethyl]-amide; [M+H]* 426. 3 -[(1 -Methyl- 1H-pyrazole-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid 1-(2-fluoro-phenyl)-1-methyl-ethy)]-amide; [M+H]* 426. 3-[(1-Methyl-1H-pyrazole-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5- carboxylic acid 1-(2-methoxy-phenyl)-1-methyl-ethyl]-amide; [M+H]* 438. 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((R)-1-phanyl-ethyl)-amide; [M+H]* 476. 3-(4-Morpholin-4-yl-ben2oylamino)-1 H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-1-phenyl-ethyl)-amide; [M+H]* 476. 3-Benzoylamino-lH-thieno[2,3-c)pyrazole-5-carboxylic acid (1-methyl-1- phenyl-ethyl)-amide; [M+H]* 405. 3-(3-Fluoro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- rnethyl-i-phenyl-ethyl)-amide; [M+H]* 423. 169) 3-(2-Fluoro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide; [M+Hf 423. Biological Testing Example The following compounds, screened according to the methods described in the pharmacology section above, were all shown to have IC50 values for Aurora-2 inhibition below 20 nM: Compounds: 1; 2; 3; 4; 5; 6; 7; 8; 9; 11; 15; 16; 17; 18; 19; 20; 21; 22; 23; 24; 25; 27; 29; 30; 31; 32; 33; 34; 35, 36; 37; 38; 39; 40; 41; 42; 46; 47; 48; 49; 50; 51; 53; 57; 58; 59; 62; 10 63; 64; 65; 122; 123; 124; 126; 131; 132; 134; 136; 137; 138; 139; 140; 141; 142; 143; 144; 147, 148; 149; 150 and 151. WE CLAIM: 1. Thieno [2,3-c]pyrazole derivatives of formula (I) (Formula Removed) and pharmaceutically acceptable salts thereof. wherein R is an optionally substituted aryl or heteroaryl group; R1 and R2 represent, the same or different and independently from each other, a hydrogen atom, a straight or branched C1-C3 alkyl or a group -CONH2 or -CHbNR'R" or, taken together with the carbon atom to which they are bonded, R1 and R2 may form a C3-C6 cycloalkyl group; with the proviso that at least one of R1 and R2 is other than a hydrogen atom; R' and R" represent, the same or different and independently from each other, a hydrogen atom or a straight or branched C1-C3 alkyl group or, taken together with the nitrogen atom to which they are bonded, R' and R" may form a heterocyclic ring of formula (Formula Removed) wherein R'" is a hydrogen atom or a straight or branched C1-C3 alkyl group; R3 is a hydrogen or halogen atom or a group selected from hydroxy, cyano, straight or branched C1-C3 alkyl or C1-C3 alkoxy; or stereoisomers, tautomers, and pharmaceutically acceptable salts thereof with the proviso that the compound not have one of R1 and R2 be a hydrogen atom, the other one of R1 and R2 be a C1-C3 alkyl and R be a 4-(l-methyl-piperazin-4-yl)phenyl. 2. A compound of formula (I) as claimed in claim 1 wherein R is a group, optionally further substituted, selected from thienyl, furyl, pyrrolyl and phenyl. 3. A compound of formula (I) as claimed in claim 1 wherein R is thienyl, furyl, pyrrolyl, N-methyl-pyrrolyl, phenyl and phenyl substituted by halogen atoms, heterocycles, heterocylyloxy or heterocylylalkyl groups. 4. A compound of formula (I) as claimed in claim 3 wherein R is selected from 2-thienyl, 2-furyl, l-methyl-pyrrolyl-2-yl, phenyl, 4-fluorophenyl, 4-(l-methyl-piperidyl-4-yloxy)phenyl, 4-(1 -methyl-piperazinyl-4-yl)phenyl, 4-( 1 -methyl-piperazinyl-4yl-methyl)phenyl, 4-(pyrrolidin-1 -yl)methyl-phenyl, 4-(piperidin-1 -yl)methyl-phenyl, 4-( 1 -methyl-piperazin-4-yl)methyl-phenyl, 4-(morpholino-1 -yl)methyl-phenyl, 4-(alkylamino)methyl-phenyl, 4-(dialkylamino)methyl-phenyl or 4-(morpholino-4-yl)phenyl. 5. A compound of formula (I) as claimed in claim 1 wherein one of R1 and R2 is a hydrogen atom or a methyl group and the remaining one of R1 and R2 is methyl, ethyl or a group -CH2NR'R" wherein R' and R" are defined in Claim 1. 6. A compound of formula (I) as claimed in claim 1 wherein R1 and R2, together with the carbon atom to which they are attached, form a C3-C6 cycloalkyl group. 7. A compound of formula (I) as claimed in claim 6 wherein R1 and R2, together with the carbon atom to which they are attached, form a cyclopropyl or cyclopentyl group. 8. A compound of formula (I) as claimed in claim 1 wherein R, R1 and R2 are as set defined in claim 1 and R3 represents a hydrogen, fluorine or chlorine atom, or a group selected from hydroxy, methoxy or cyano. 9. A compound of formula (I) as claimed in claim 1 wherein R is optionally substituted, in any of its free positions, by from 1 to 6 groups, selected from: halogen, nitro, carboxy, cyano, alkyl, polyfluorinated alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl; aryl, heterocyclyl, alkyl-heterocyclyl, heterocyclyl-alkyl, amino-alkyl, amino groups and alkylamino, dialkylamino, arylamino, diarylamino, ureido, alkylureido or arylureido; carbonylamino groups and formylamino, alkylcarbonylamino, alkenylcarbonylamino, arylcarbonylamino, alkoxycarbonylamino; hydroxy groups and alkoxy, polyfluorinated alkoxy, aryloxy, heterocylyloxy, alkylcarbonyloxy, arylcarbonyloxy, cycloalkenyloxy or alkylideneaminoxy; carbonyl groups and alkylcarbonyl, arylcarbonyl, alkoxy carbonyl, aryloxycarbonyl, cycloalkyloxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl; alkylthio, arylthio, alkylsulfonyl, arylsulfonyl, alkylsulfinyl, arylsulfinyl, arylsulfonyloxy, aminosulfonyl, alkylaminosulfonyl or dialkylaminosulfonyl. 10. A compound of formula (I) as claimed in claim 1, optionally in the form of a pharmceutically acceptable salt thereof, selected from the group consisting of: 1) N-(l-methyl-l-phenylethyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 2) 3-[(4-morpholin-4-ylbenzoyl)amino]-N-(l-phenylcyclopropyl)-1H-thieno[2,3-c]pyrazole-5 -carboxamide; 3) N-[(lR)-l-(4-fluorophenyl)ethyl]-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 4) 3 -[(4-morpholin-4-ylbenzoyl)amino]-N- [(1R)-1 -phenylpropyl] -1H-thieno [2,3 -c]pyrazole-5-carboxamide; 5) 3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(lS)-l-phenyl-2-pyrrolidin-l-ylethyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 6) 3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(lS)-2-morpholin-4-yl-l-phenylethyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 7) 3-[(4-fluorobenzoyl)amino]-N-(l-phenylcyclopropyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 8) 3-[(4-fluorobenzoyl)amino]-N-(l-methyl-l-phenylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 9) 3-[(4-fluorobenzoyl)amino]-N-[(1R)-1-phenylpropyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 10) 3-[(4-fluorobenzoyl)amino]-N-[(1S)-1 -phenyl-2-pyrrolidin-1 -ylethyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 11) 3-[(4-fluorobenzoyl)amino]-N-[(lR)-l-(4-fluorophenyl)ethyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 12) 3-[(4-fluorobenzoyl)amino]-N-[(1S)-2-morpholin-4-yl-1 -phenylethyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 13) N-(l -ethyl-1 -phenylpropyl)-3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 14) 3-[(4-fluorobenzoyl)amino]-N-(l-phenylcyclopentyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 15) N-[(1S)-2-morpholin-4-yl-l -phenylethyl]-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5 -carboxamide; 16) N-( 1 -methyl-1 -phenylethyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno [2,3-c]pyrazole-5-carboxamide; 17) N-[(lR)-l-(4-fluorophenyl)ethyl]-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 18) N-( 1 -phenylcyclopropyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 19) N-[(1S)-1 -phenyl-2-pyrrolidin-1 -ylethyl]-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 20) N-[(lR)-l-phenylpropyl]-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 21) N-( 1 -methyl-1 -phenylethyl)-3 - {[(1 -methyl-1H-pyrrol-2-yl)carbonyl]amino } -1H-thieno[2,3-c]pyrazole-5-carboxamide; 22) 3 - {[(1 -methyl-1H-pyrrol-2-yl)carbonyl]amino } -N-( 1 -phenylcyclopropyl)-1H-thieno [2,3-c]pyrazole-5-carboxamide; 23) 3-(2-furoylamino)-N-(l-phenylcyclopropyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 24) 3-(2-furoylamino)-N-( 1 -methyl-1 -phenylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 25) N-( 1 -methyl-1 -phenylethyl)-3 -({4-[( 1 -methylpiperidin-4-yl)oxy]benzoyl} amino)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 26) 3-( {4-[( 1 -methylpiperidin-4-yl)oxy]benzoyl }amino)-N-( 1 -phenylcyclopropyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 27) N-( 1 -methyl-1 -phenylethyl)-3 -({4- [(4-methylpiperazin-1 -yl)methyl]benzoy 1} amino)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 28) 3-({4-[(4-methylpiperazin-1 -yl)methyl]benzoyl} amino)-N-( 1 -phenylcyclopropyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide: 29) N-( 1 -methyl-1 -phenylethyl)-3 - {[4-(4-methylpiperazin-1 -yl)benzoy l]amino } -1H-thieno[2,3-c]pyrazole-5-carboxamide; 30) 3-{[4-(4-methylpiperazin-l-yl)benzoyl]amino}-N-[(lR)-l-phenylpropyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 31) 3- {[4-(4-methylpiperazin-1 -yl)benzoyl]amino }-N-[(1S)-2-morpholin-4-yl-1 -phenylethyl] -1H-thieno [2,3-c]pyrazole-5 -carboxamide; 32) 3-{ [4-(4-methylpiperazin-1 -yl)benzoyl]amino} -N-[(1S)-1 -phenyl-2-pyrrolidin-1 -ylethyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 33) N-( 1 -ethyl-1 -phenylpropyl)-3 - {[4-(4-methylpiperazin-1 -yl)benzoyl]amino } -1H-thieno[2,3-c]pyrazole-5-carboxamide; 34) 3- {[4-(4-methylpiperazin-1 -yl)benzoyl]amino} -N-( 1 -phenylcyclopentyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 35) 3-{[4-(4-methylpiperazin-l-yl)benzoyl]amino}-N-(l-phenylcyclopropyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide; 36) 3-(4-Pyrrolidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1- methyl-1 -phenyl-ethyl)-amide; 37) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 3 8) 3-(4-Piperidin-1 -ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid( 1 -methyl-1 -phenyl-ethyl)-amide; 39) 3-[4-(Isopropylamino-methyl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 40) 3-[4-( 1,1 -Dioxo-1 -thiomorpholin-4-ylmethyl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxyIic acid( 1 -methyl-1 -phenyl-ethyl)-amide; 41) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-fluoro-phenyl)-1 -methyl-ethyl]-amide; 42) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 43) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(4-fluoro-pheny 1)-1 -methyl-ethyl] -amide; 44) 4-{4-[5-( 1 -Methyl-1 -phenyl-ethylcarbamoyl)-1H-thieno[2,3-c]pyrazol-3-ylcarbamoyl]-benzyl}-piperazine-l-carboxylic acid tert-butyl ester; 45) 3-[4-(4-Fluoro-piperidin-l-ylmethyl)-benzoylamino]-1H-thieno[2,3-cpyrazole-5-carboxylic acid (1 -methyl- l-phenyl-ethyl)-amide; 46) 3-(4-Piperazin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 47) 3-(4-Imidazol-1 -ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 48) 3-(4-Thiazolidin-3-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 49) 3-(4-Pyrrolidin-1 -ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-fluoro-phenyl)-1 -methyl-ethyl]-amide; 50) 3-(4-Piperidin-1 -ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-fluoro-phenyl)-l-methyl-ethyl]-amide; 51) 3-(4-Piperidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 52) 3-(4-Azetidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methy 1-1 -phenyl-ethyl)-amide; 53) 3-(4-Azetidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 54) 3-(4-Azetidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-fluoro-phenyl)-1 -methyl-ethyl]-amide; 55) 3-(4-Azetidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(4-fluoro-phenyl)-1 -methyl-ethyl]-amide; 56) 3-[4-(4-tert-Butyl-piperazin-l-ylmethyl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 57) 3-(4-Pyrrolidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(4-fluoro-phenyl)-1 -methyl-ethyl]-amide; 58) 3-(4-Piperidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(4- fluoro-phenyl)-1 -methyl-ethyl]-amide; 59) 3-Phenylacetylamino-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 60) 3-(4-Dimethylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 61) 3-(4-Cyclopropylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 62) 3-(4-Cyclobutylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (l-methyl-l-phenyl-ethyl)-amide; 63) 3-{4-[(Isopropyl-methyl-amino)-methyl]-benzoylamino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 64) 3-(4-Cyclopentylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 65) 3-{4-[(Diisopropylamino)-methyl]-benzoylamino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 66) 3-(4-Aminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -phenyl-ethyl)-amide; 67) 3-(4-Pyrrolidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 68) 3-(4-Pyrrolidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(2-methoxy-phenyl)-l-methyl-ethyl]-amide; 69) 3-(4-Pyrrolidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-methoxy-phenyl)-1 -methyl-ethyl]-amide; 70) 3-(4-Pyrrolidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(4-methoxy-phenyl)-l-methyl-ethyl]-amide; 71) 3-(4-Piperidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(4-methoxy-phenyl)-1 -methyl-ethyl]-amide; 72) 3-(4-Piperidin-1 -ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-methoxy-phenyl)-1 -methyl-ethyl]-amide; 73) 3-(4-Piperidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-methoxy-phenyl)-1 -methyl-ethyl]-amide; 74) 3-(4-Azetidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-methoxy-pheny 1)-1 -methyl-ethyl] -amide; 75) 3-(4-Azetidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-methoxy-phenyl)-1 -methyl-ethyl]-amide; 76) 3-(4-Azetidin-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(4-methoxy-phenyl)-1 -methyl-ethyl]-amide; 77) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(4-methoxy-phenyl)-l-methyl-ethyl]-amide; 78) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3 -methoxy-pheny 1)-1 -methyl-ethyl] -amide; 79) 3-(4-Morpholin-4-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(2-methoxy-phenyl)-l-methyl-ethyl]-amide; 80) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-methyl-l-(2-methoxy-phenyl)-ethyl]-amide; 81) 3-[4-(4-Methyl-piperazin-l -yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-methyl-l-(3-methoxy-phenyl)-ethyl]-amide; 82) 3-[4-(4-Methyl-piperazin-1 -yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-methyl-l-(4-methoxy-phenyl)-ethyl]-amide; 83) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-1 -(2-fluoro-phenyl)-ethyl] -amide; 84) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-1 -(3-fluoro-phenyl)-ethyl]-amide; 85) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-methyl-l-(4-fluoro-phenyl)-ethyl]-amide; 86) 3-({4-[(l-methylpiperidin-4-yl)oxy]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-l-(2-fluoro-phenyl)-ethyl]-amide; 87) 3-({4-[(l-methylpiperidin-4-yl)oxy]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-l-(3-fluoro-phenyl)-ethyl]-amide; 88) 3-({4-[(l-methylpiperidin-4-yl)oxy]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-l-(4-fluoro-phenyl)-ethyl]-amide; 89) 3-({4-[(l-methylpiperidin-4-yl)oxy]benzoyl}amino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-l-(4-methoxy-phenyl)-ethyl]-amide; 90) 3-( {4- [(1 -methylpiperidin-4-yl)oxy]benzoyl} amino)-1H-thieno [2,3 -c]pyrazole-5 -carboxylic acid [1-methyl-l-(3-methoxy-phenyl)-ethyl]-amide; 91) 3 -( {4-[( 1 -methylpiperidin-4-yl)oxy]benzoyl} amino)-1H-thieno [2,3 -c]pyrazole-5-carboxylic acid [1-methyl-l-(2-methoxy-phenyl)-ethyl]-amide; 92) 3-(4-Cyclopropylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 1 -(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 93) 3-(4-Cyclopropylaminomethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 1 -(2-methoxy-phenyl)-1 -methyl-ethyl]-amide; 94) 3-[4-(Isopropylamino-methyl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 1 -(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 95) 3-[4-(Isopropylamino-methyl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 1 -(2-methoxy-phenyl)-1 -methyl-ethyl]-amide; 96) 3-(4-Azepan-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -phenyl-ethyl)-amide; 97) 3-(4-Azepan-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1 -methyl-ethyl] -amide; 98) 3-(4-Pyrazol-l-ylmethyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -phenyl-ethyl)-amide; 99) 3-(4-methoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 100) 3-(3-methoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 101) 3-(2-methoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 102) 3-(3-Moq)holin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -phenyl-ethyl)-amide; 103) 3-[4-(4-Methyl-piperazin-l -yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 104) 3-(4-Dimethylamino-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methy 1-1 -phenyl-ethyl)-amide;) 105) 3-[(Furan-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 106) 3-[(Thiophene-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -phenyl-ethyl)-amide; 107) 3-[(l-Methyl-1H-pyrrole-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 108) 3-[(l-Methyl-1H-pyrazole-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 109) 3-[(l-Methyl-1H-pyrazole-5-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 110) 3-[(Pyridine-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -phenyl -ethyl)-amide; 111) 3-[(Pyridine-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -phenyl-ethyl)-amide; 112) 3-[(Pyridine-4-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -phenyl-ethyl)-amide; 113) 3-(4-Chloro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 114) 3-(4-Phenoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 115) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(2-methoxy-phenyl)-1 -methyl-ethyl]-amide; 116) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(4-methoxy-phenyl)-1 -methyl-ethyl] -amide; 117) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid[1-(2-methoxy-phenyl)-1 -methyl-ethyl]-amide; 118) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid[l-(3-methoxy-phenyl)-l-methyl-ethyl]-amide; 119) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid[1-(4-methoxy-phenyl)-1 -methyl-ethyl]-amide; 120) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-ethyl-1 -phenyl-propyl)-amide; 121) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-phenyl-cyclopentyl)-amide; 122) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(2-fluoro-phenyl)-1 -methyl-ethyl] -amide; 123) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(3-fluoro-phenyl)-1 -methyl-ethyl]-amide; 124) 3-(4-Trifluoromethoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-2-morpholin-4-yl-1 -phenyl-ethyl)-amide; 125) 3-[4-(2-Dimethylamino-ethoxy)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 126) 3-[4-(2-Dimethylamino-ethoxy)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; 127) 3-(4-Fluoro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-l-phenyl-2-piperidin-1 -yl-ethyl)-amide; 128) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-ethyl-1 -phenyl-propyl)-amide; 129) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-l-phenyl-2-piperidin-1 -yl-ethyl)-amide; 130) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-phenyl-cyclopentyl)-amide; 131) 3-[4-(4-Methyl-piperazin-l -yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid[1-(3 -chloro-phenyl)-1 -methyl-ethyl]-amide; 132) 3-(4-Fluoro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-chloro-phenyl)-l-methyl-ethyl]-amide; 133) 3-(4-Methoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -phenyl-cyclopropyl)-amide; 134) 3-(4-Trifluoromethoxy-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-phenyl-cyclopropyl)-amide; 135) 3-[(6-Morpholin-4-yl-pyridine-3-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide; 136) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-l-methyl-2-morpholin-4-yl-1 -phenyl-ethyl)-amide; 137) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1 -pyridin-4-yl-ethyl)-amide; 138) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(4-fluoro-phenyl)-1 -methyl-ethyl] -amide; 139) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(3-methoxy-phenyl)-l-methyl-ethyl]-amide; 140) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid[1-(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 141) 3-[4-(4-Methyl-piperazin-1 -yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-(3-fluoro-phenyl)-1 -methyl-ethyl]-amide; 142) 3-(4-Methanesulfonyl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid( 1 -methyl-1 -phenyl-ethyl)-amide; 143) 3-[4-( 1,1 -Dioxo-thiomorpholin-4-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl- l-phenyl-ethyl)-amide; 144) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-1 -(3-pyrrolidin-1 -yl-phenyl)-ethyl]-amide; 145) 3-[4-(4-Methyl-piperazin-l-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [1-methyl-1 -(3-pyrrolidin-1 -yl-phenyl)-ethyl]-amide; 146) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(3-methanesulfonyl-phenyl)-1 -methyl-ethyl]-amide; 147) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 148) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(3-fluoro-phenyl)-l-methyl-ethyl]-amide; 149) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(4-fluoro-phenyl)-1 -methyl-ethyl]-amide; 150) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(4-fluoro-phenyl)-l-methyl-ethyl]-amide; 151) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(2-methoxy-phenyl)-1 -methyl-ethyl]-amide; 152) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(3-methoxy-phenyl)-1 -methyl-ethyl]-amide; 153) 3-[(Thiophene-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [l-(4-methoxy-phenyl)-1 -methyl-ethyl]-amide; 154) 3-[(Furan-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid l-(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 155) 3-[(Furan-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid l-(3-fluoro-phenyl)-1 -methyl-ethyl]-amide; 156) 3-[(Furan-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid l-(4-fluoro-phenyl)-l-methyl-ethyl]-amide; 157) 3-[(Furan-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid l-(2-methoxy-phenyl)-1 -methyl-ethyl] -amide; 158) 3-[(l-Methyl-1H-pyrazole-5-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid l-(2-fluoro-phenyl)-l-methyl-ethyl]-amide; 159) 3-[( 1 -Methyl-1H-pyrazole-5-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid l-(2-methoxy-phenyl)-l-methyl-ethyl]-amide; 160) 3-[( 1 -Methyl-1H-pyrazole-5-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid l-(4-fluoro-phenyl)-l-methyl-ethyl]-amide; 161) 3-[( 1 -Methyl-1H-pyrazole-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 1 -(2-fluoro-phenyl)-1 -methyl-ethyl] -amide; 162) 3-[( 1 -Methyl-1H-pyrazole-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 1 -(2-fluoro-phenyl)-1 -methyl-ethyl]-amide; 163) 3-[( 1 -Methyl-1H-pyrazole-2-carbonyl)-amino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid l-(2-methoxy-phenyl)-l-methyl-ethyl]-amide; 164) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((R)-l- phenyl-ethyl)-amide; 165) 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid ((S)-l- phenyl-ethyl)-amide; 166) 3-Benzoylamino-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)- amide 167) 3-(3-Fluoro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1 -methyl-1 -phenyl-ethyl)-amide; and 168) 3-(2-Fluoro-benzoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-l-phenyl-ethyl)-amide. 11. A process for preparing the compounds of formula (I) and the pharmaceutically acceptable salts thereof, as claimed in claim 1, which process comprises: (a) reacting a compound of formula (II), wherein Alk stands for a C1-C6 alkyl group, with hydrazine or a hydrazine salt in methanol, ethanol or tetrahydrofuran at a temperature ranging from 15°C to 50 °C and reacting the thus obtained intermediate compound under acidic conditions so as to obtain a compound of formula (III) (Formula Removed) (b) reacting the compound of formula (III) with any suitable pyrazole nitrogen atom protecting agent in a suitable solvent such as tetrahydrofuran, dichloromethane, chloroform,acetonitrile, toluene or mixtures thereof; at a temperature ranging from -15 °C to 35 °C , for a time varying from 30 minutes to 72 hours,in the presence of an opportune proton scavenger such as triethylamine or diisopropylethlamine so as to obtain a compound of formula (IV), in any one of its tautomeric forms (IVa) or (IVb) (Formula Removed) and wherein Q represents the said protecting group; (c) acylating the compound of formula (IV) with a compound of formula (V), in a suitable solvent such as tetrahydrofuran, dimethylformamide, dichloromethane, chloroform, acetonitrile, toluene or mixtures thereof; at a temperature ranging from -10 °C to reflux , for a time varying from 30 minutes to 96 hours, in the presence of an opportune proton scavenger such as triethylamine, diisopropylethlamine or pyridine wherein R is as defined in claim 1 and Z represents a suitable leaving group, so as to obtain a compound of formula (VI) (Formula Removed) (d) selectively hydrolyzing the tert-butyl carboxyester group so as to obtain a compound of formula (VII) under acidic conditions, preferably in the presence of hydrochloric acid in dioxane,by operating at room temperature and for a suitable time, for instance up to 72 hours (Formula Removed) (e) reacting the compound of formula (VII) with a compound of formula (VIII) wherein R1, R2 and R3 are as defined in claim 1, in the presence of any suitable condensing agent, so as to obtain a compound of formula (IX) (Formula Removed) (f) deprotecting the compound of formula (IX) from the Q pyrazole nitrogen atom protecting group so as to obtain the compound of formula (I) and, whenever desired, converting the compound of formula (I) into a pharmaceutically acceptable salt or converting the salt thereof into the free compound of formula (I) at a temperature ranging from 18°C to refluxing temperature of the solvent, for a time varying from 30 minutes to 72 hours (f) optionally treating the compound of formula (IX), wherein R is a phenyl group substituted at position 4' with a chloromethyl group with ammonia or a primary or secondary amine in a suitable solvent such as methanol, ethanol, tetrahydrofuran, dimethylformamide, at a temperature ranging from 0°C to the reflux temperature of the solvent, to deprotect and converting them into a compound of formula I, wherein R is an optionally substituted 4'-(amino-methyl)phenyl group: (Formula Removed) 12. The process as claimed in claim 11 wherein, within the compounds of formula (II), Alk represents ethyl. 13. The process as claimed in claim 11 wherein, within the compounds of formula (IV), Q represents the group ethoxycarbonyl (-COOEt). 14. The process as claimed in any one of claims 11 or 12 wherein, within the compounds of formula (V), Z represents a chlorine or bromine atom. 15. A compound of formula (I) or a pharmaceutically acceptable salt thereof, as claimed in claim 1, for use as a medicament in anticancer therapy wherein the cancer is ovarian carcinoma or colon carcinoma.

Documents:

4402-DELNP-2006-Abstract-(15-05-2012).pdf

4402-DELNP-2006-Abstract-(21-05-2012).pdf

4402-delnp-2006-abstract.pdf

4402-DELNP-2006-Assignment-(09-03-2011).pdf

4402-DELNP-2006-Claims-(15-05-2012).pdf

4402-DELNP-2006-Claims-(21-05-2012).pdf

4402-delnp-2006-Claims-(28-01-2013).pdf

4402-delnp-2006-claims.pdf

4402-delnp-2006-Correspondence Others-(10-01-2013).pdf

4402-DELNP-2006-Correspondence Others-(15-05-2012).pdf

4402-DELNP-2006-Correspondence Others-(21-05-2012).pdf

4402-delnp-2006-Correspondence Others-(28-01-2013).pdf

4402-delnp-2006-Correspondence-Others-(06-03-2013).pdf

4402-DELNP-2006-Correspondence-Others-(09-03-2011).pdf

4402-delnp-2006-correspondence-others-(30-01-2008).pdf

4402-delnp-2006-correspondence-others.pdf

4402-delnp-2006-description (complete).pdf

4402-DELNP-2006-Form-1-(09-03-2011).pdf

4402-DELNP-2006-Form-1-(21-05-2012).pdf

4402-delnp-2006-form-1.pdf

4402-delnp-2006-form-18-(30-01-2008).pdf

4402-DELNP-2006-Form-2-(09-03-2011).pdf

4402-DELNP-2006-Form-2-(21-05-2012).pdf

4402-delnp-2006-form-2.pdf

4402-delnp-2006-Form-3-(06-03-2013).pdf

4402-DELNP-2006-Form-3-(15-05-2012).pdf

4402-delnp-2006-Form-3-(28-01-2013).pdf

4402-delnp-2006-form-3.pdf

4402-delnp-2006-form-5.pdf

4402-DELNP-2006-GPA-(09-03-2011).pdf

4402-DELNP-2006-GPA-(15-05-2012).pdf

4402-delnp-2006-GPA-(28-01-2013).pdf

4402-delnp-2006-gpa.pdf

4402-delnp-2006-pct-210.pdf

4402-delnp-2006-pct-304.pdf

4402-delnp-2006-pct-306.pdf

4402-delnp-2006-pct-409.pdf

4402-DELNP-2006-Petition-137-(15-05-2012).pdf

4402-delnp-2006-Petition-137-(28-01-2013).pdf