| Title of Invention | PYRIMIDINE COMPOUNDS |
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| Abstract | Provided herein are heterocyclic compounds of the general formula (I), th~ir derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R<sub>1</sub>, R<sub>2</sub>, R<sub>3</sub> R<sub>4</sub> and R<sub>5</sub> are as described herein: Further described herein in particular are heterocyclic compounds of the formula (I) for treati~g various diseases and disorders by administering in a patient one or more TNF -<1, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn"s disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-I; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-I, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I). |
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488-che-2005-correspodance others.pdf
488-CHE-2007 AMENDED PAGES OF SPECIFICATION 12-10-2012.pdf
488-CHE-2007 AMENDED CLAIMS 12-10-2012.pdf
488-CHE-2007 FORM-3 12-10-2012.pdf
488-CHE-2007 AMENDED PAGES OF SPECIFICATION 23-08-2013.pdf
488-CHE-2007 AMENDED CLAIMS 23-08-2013.pdf
488-CHE-2007 EXAMINATION REPORT REPLY RECEIVED 12-10-2012.pdf
488-CHE-2007 FORM-1 23-08-2013.pdf
488-CHE-2007 EXAMINATION REPORT REPLY RECEIVED 23-08-2013.pdf
488-CHE-2007 FORM-3 23-09-2009.pdf
488-che-2007-description(provisional).pdf
| Patent Number | 257134 | ||||||||||||||||||||||||
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| Indian Patent Application Number | 488/CHE/2007 | ||||||||||||||||||||||||
| PG Journal Number | 36/2013 | ||||||||||||||||||||||||
| Publication Date | 06-Sep-2013 | ||||||||||||||||||||||||
| Grant Date | 05-Sep-2013 | ||||||||||||||||||||||||
| Date of Filing | 09-Mar-2007 | ||||||||||||||||||||||||
| Name of Patentee | Orchid Research Laboratories Ltd | ||||||||||||||||||||||||
| Applicant Address | ORCHID TOWERS 313 VALLUVAR KOTTAM HIGH ROAD NUNGAMBAKKAM ,CHENNAI -600 034 | ||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | C07D 413/14 | ||||||||||||||||||||||||
| PCT International Application Number | N/A | ||||||||||||||||||||||||
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