| Title of Invention | A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO) PROPYLIDENE]-6,11-DIHYDRODIBENZ[b,e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE |
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| Abstract | The present invention relates to an improved process for the preparation of 11-(Z)-[3-(Dimethylamino) propylidene]-6, 11-dihydrodibenz[b,e]oxepin-2-acetic acid (Olopatadine hydrochloride) by reaction of 11-oxo-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid with Grignard reagent of 1-halo-3-dimethylaminopropane and further dehydrated with or without isolation of the intermediate 11-(3-dimethylaminopropyl)-11-hydroxy-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid. The present invention relates novel polymorphs of 11-(Z)-[3-Dimethylamino) propylidene]-6, 11-dihydrodibenz[b,e]oxepin-2-acetic acid (Olopatadine hydrochloride). The present invention further relates to preparation of 11-(E)-[3-Dimethylamino) propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride. |
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223-mum-2006-correspondence 1(29-5-2007).pdf
223-mum-2006-correspondence 2(24-11-2006).pdf
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223-mum-2006-correspondence(ipo)-(12-12-2006).pdf
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223-MUM-2006-FORM PCT-IB-373(27-1-2012).pdf
223-MUM-2006-FORM PCT-ISA-237(27-1-2012).pdf
223-MUM-2006-REPLY TO EXAMINATION REPORT(21-6-2012).pdf
223-MUM-2006-SPECIFICATION(AMENDED)-(21-6-2012).pdf
223-MUM-2006-SPECIFICATION(MARKED COPY)-(21-6-2012).pdf
| Patent Number | 256809 | |||||||||||||||||||||||||||||||||
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| Indian Patent Application Number | 223/MUM/2006 | |||||||||||||||||||||||||||||||||
| PG Journal Number | 31/2013 | |||||||||||||||||||||||||||||||||
| Publication Date | 02-Aug-2013 | |||||||||||||||||||||||||||||||||
| Grant Date | 31-Jul-2013 | |||||||||||||||||||||||||||||||||
| Date of Filing | 14-Mar-2006 | |||||||||||||||||||||||||||||||||
| Name of Patentee | USV LIMITED | |||||||||||||||||||||||||||||||||
| Applicant Address | B.S.D. MARG, STATION ROAD, GOVANDI, MUMBAI 400 088, | |||||||||||||||||||||||||||||||||
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| PCT International Classification Number | C07D313/12 | |||||||||||||||||||||||||||||||||
| PCT International Application Number | N/A | |||||||||||||||||||||||||||||||||
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