Title of Invention	"3- AMINOPYRROLIDONE DERIVATIVES"
Abstract	The present invention is related to a compound of general formula

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3-AMINOPYRROLIDONE DERIVATIVES This invention is related to 3-aminopyrrolidone derivatives and analogues of the following general formula I (Figure Remove) I and pharmaceutically acceptable salts thereof, that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role. BACKGROUND OF THE INVENTION Chemical background WO97/05111 discloses N-(4-substituted-benzyl)-2-aminolactam derivatives of general formula II (Figure Remove) wherein: m is zero, 1, 2 or 3; n is zero, 1, 2ot3;X is O, S, CH2 or NH; each of R and RI independently is hydrogen, CpCe alkyl, halogen, hydroxy, CrC4 alkoxy or trifluoromethyl; each of R2, R3 and R4 independently is hydrogen, Ci-C6 alkyl optionally substituted by a hydroxy group, or C3-C7 cycloalkyl. The compounds of the invention are active on the central nervous system (CNS) and can be used in therapy, for example as antiepileptics, in the treatment of Parkinson's disease and as neuroprotective agents, e.g. preventing or treating neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycaemia or surgery and in treating or preventing neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis, Down's syndrome or Huntington's disease; they can also be used as antidepressants, hypnotics and antispastic agents. In WO 96/40679, WO 95/33719 and US 3,714,175 N-substituted pyrrolidone derivatives are claimed to be active as anticoagulants (Factor Xa), herbicidals and muscle relaxants, respectively. In EP 0362941, N-OH substituted pyrrolidone derivatives are claimed to be active as anticonvulsants, muscle relaxants and in anti-neurodegenerative disorders. Biological background It is,well known that sodium channels play an important role in the neuronal network by transmitting electrical impulses rapidly throughout cells and cell networks, thereby coordinating higher processes ranging from locomotion to cognition. These channels are large transmembrane proteins, which are able to switch between different states to enable selective permeability for sodium ions. For this process an action potential is needed to depolarize the membrane, and hence these channels are voltage-gated. In the past few years a much better understanding of sodium channels and drugs interacting with them has been developed. It has become clear that a number of drugs having an unknown mechanism of action actually act by modulating sodium channel conductance, including local anesthetics, class I antiarrhythmics and anticonvulsants. Neuronal sodium channel blockers have found application with their use in the treatment of epilepsy (phenytoin and carbamazepine), bipolar disorder (lamotrigine), preventing neurodegeneration, and in reducing neuropathic pain. Various anti-epileptic drugs that stabilize neuronal excitability are effective in neuropathic pain (gabapentin). In addition, an increase in sodium channel expression or activity has also been observed in several models of inflammatory pain, suggesting a role of sodium channels in inflammatory pain. Calcium channels are membrane-spanning, multi-subunit proteins that allow controlled entry of calcium ions into cells from the extracellular fluid. Commonly, calcium channels are voltage dependent and are referred to as voltage sensitive calcium channels (VSCC). VSCCs are found throughout the mammalian nervous system, where they regulate such varied activities as cellular excitability, transmitter release, intracellular metabolism, neurosecretory activity and gene expression. All "excitable" cells in animals, such as neurons of the central nervous system (CNS), peripheral nerve cells, and muscle cells, including those of skeletal muscles, cardiac muscles and venous and arterial smooth muscles, have voltage dependent calcium channels. Calcium channels have a central role in regulating intracellular calcium ions levels that are important for cell viability and function. Intracellular calcium ion concentrations are implicated in a number of vital processes in animals, such as neurotransmitter release, muscle contraction, pacemaker activity, and secretion of hormones. It is believed that calcium channels are relevant in certain disease states. A number of compounds useful in treating various cardiovascular diseases in mammals, including humans, are thought to exert their beneficial effects by modulating functions of voltage dependant calcium channels present in cardiac and/or vascular smooth muscle. Compounds with activity against calcium channels have also been implicated for the treatment of pain. In particular N-type calcium channels (Cav2.2), responsible for the regulation of neurotransmitters, are thought to play a significant role in nociceptive transmission, both due to their tissue distribution as well as from the results of several pharmacological studies. This hypothesis has been validated hi the clinic by Zinocotide, a. peptide derived from the venom of the marine snail, Conus Magus. A limitation in the therapeutic use of this peptide is that it has to be administered intrathecally in humans (Bowersox S. S. and Luther R. Toxicon, 1998, 36, 11, 1651-1658). All together these findings indicate that compounds with sodium and/or calcium channel blockade have a high therapeutic potential in preventing, alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role. There are many papers and patents which describe sodium channel and/or calcium channel modulators or antagonists for the treatment or modulation of a plethora of disorders, such as their use as local anesthetics, antiarrhythmics, antiemetics, antimanic depressants, agents for the treatment of unipolar depression, cardiovascular diseases, urinary incontinence, diarrhea, inflammation, epilepsy, neurodegenerative conditions, nerve cell death, anticonvulsants, neuropathic pain, migraine, acute hyperalgesia and inflammation, renal disease, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, urinary tract disorders, gastrointestinal motility disorders, premature labour, obesity. A largely incomplete list is shown below. An extensive and thorough prior art overview is reported in WO 03/057219 (and references therein); a further selection of prior art is reported in the following references: Alzheimer, C. Adv. Exp. Med. Biol. 2002, 513, 161-181; Vanegas, H.; Schaible, H. Pain 2000, 85, 9-18; U.S. Patent 5,051,403; U.S. Patent 5,587,454; U.S. Patent 5,863,952; U.S. Patent 6,011,035; U.S. Patent 6,117,841; U.S. Patent 6,362,174; U.S. Patent 6,380,198; U.S. Patent 6,420,383; U.S. Patent 6,458,781; U.S. Patent 6,472,530; U.S. Patent 6,518,288; U.S. Patent 6,521,647; WO 97/10210; WO 03/018561. DESCRIPTION OF THE INVENTION The present invention relates to the use of compounds of formula I (Figure Remove) O R* wherein m is an integer from 1 to 3 X is methylene, oxygen, sulphur or a NR6 group; R1 is a straight or branched Ci-Cg alkyl or C3-C8 alkenylene or C3-Cg alkynylene chain, optionally substituted with CFs, phenyl, phenoxy or naphthyl, or phenyl, the aromatic rings optionally substituted by one or more CpC4 alkyl, halogens, trifluoromethyl, hydroxy or CpC4 alkoxy groups; R2, R3 are independently hydrogen, a Ci-Ca alkyl chain, halogen, trifluoromethyl, hydroxy or Ci-C4 alkoxy groups; R4, R5, R6 are independently hydrogen or Q-Ce alkyl; and the pharmaceutically acceptable salts thereof for the preparation of a medicament for the treatment of pain, migraine, cognitive disorders, inflammation, gastrointestinal tract disorders, disorders of the genito-urinary tract, ophthalmic diseases, obesity. This invention is also related to the compounds of the general formula I wherein m, X, R1, R2, R3, R4, R5 and R6 are as defined above with the proviso that: - when R1 is phenyl, benzyl, 2-phenethyl or 3-phenpropyl optionally and independently substituted on the phenyl ring by one or two Ci-Cg alkyl, halogen, hydroxy, CpC4 alkoxy or trifluoromethyl; X is oxygen, sulphur, methylene or -NH-, at least one of R2 and R3 is other than hydrogen; The disclaimed compounds are known from WO97/05 111. - if m is 3, R!-X 4-benzyloxy, R2, R4 and R5 hydrogen then R3 is other than 3-methoxy (CGX-0154772), and - if m is 3, RJ-X 3-benzyloxy, R2, R4 and R5 hydrogen then R3 is other than 4-methoxy (CGX-0154682). The optional substituents R]-X, R2 and R3 in the phenyl ring may be hi any position. The pharmaceutically acceptable salts of the compounds of formula I include acid addition salts with inorganic, e.g. hydrochloric, hydrobromic, sulphuric, and phosphoric acids or organic, e.g. acetic, propionic, benzoic, cinnamic, mandelic, salicylic, glycolic, lactic, oxalic, malic, maleic, malonic, fumaric, tartaric, citric, and the like. Preferred use compounds of the invention are the compounds of formula I wherein m is 1 or 2, X is oxygen or methylene or NH or NCH3, R1 is Ci-Cg alkyl chain, optionally substituted with CFa, phenyl or phenoxy group, where the aromatic ring in R1 is optionally substituted by one or two halogen or methoxy or trifluoromethyl groups, R2 and R3 are hydrogen, methyl, methoxy, fluorine, chlorine or bromine, R4 and R5 are hydrogen or methyl, halogen is chlorine or fluorine. Examples of specific use compounds of the invention are: 3-(4-Butyloxy-benzylamino)-pyrrolidin-2-one; 3-[4-(4-trifluorobutyloxy)-benzylamino]-pyrrolidin-2-one; 3-(4-Pentyloxy-benzylamino)-pyrrolidin-2-one; 3-[4-(5-trifluoropentyloxy)-benzylamino]-pyrrolidin-2-one; 3-(4-Phenylethyl-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylbutoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy)-benzylamino-pyrrolidin-2-one; 3 -(4-Phenoxy ethoxy-benzy lamino)-pyrro lidin-2-one; 3-[4-(Naphthalen-l-ylmethoxy)-benzylammo]-pyrrolidin-2-one; 3-(4-Pentyloxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3 -(4-Pentyloxy-3 -chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3-methyl-benzylamino)-pyrrolidm-2-one; 3 -(4-Benzyloxy-3 -fluoro-benzylamino)-pyrrolidhi-2-one; 3-(4-Benzyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3 -(4-Phenoxy ethoxy-3 -bromo-benzylamino)-pynolidin-2-one; 3-(4-Phenoxyethoxy-3-metboxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3 - [4-(Naphthalen-1 -ylmethoxy)-3-bromo-benzylamino]-pyrrolidin-2- one; 3-[4-(Naphthalen-l-ylmethoxy)-3-methoxy-benzylamino]-pyrrolidin-2- one; 3-[4-(Naphthalen-l-ylmethoxy)-3-methyl-benzylamino]-pyrrolidin-2- one; 3-(4-Pentyloxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3,5-dimethoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3,5-dimethoxy-benzylamino)-pyiTolidin-2-one; 3-(4-Benzyloxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2- one; 3-(4-Phenylallyloxy"3,5-dimethoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2- one; 3 -(4-Pheny Ipentoxy- 3,5-dimethoxy-benzy lamino)-pyrrolidin-2- one; 3-(4-Phenylpentoxy-3,5-dimethyl-ben2ylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2- one; 3-(4-Phenoxyethoxy-3,5-dimethoxy-ben2ylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3 - [4-(Naphthalen-1 -ylmethoxy)-2-chloro-5 -methoxy-benzy lamino]- pyrrolidin-2-one; 3 -[4-(Naphthalen-1 -ylmethoxy)-3-fluoro-5-methoxy-benzylamino]- pyrrolidin-2-one; 3-[4-(Naphthalen-l-ylmethoxy)-3-bromo-5-methoxy-benzylamino]- pyrrolidin-2-one; 3 - [4-(Naphthalen-1 -ylmethoxy)-3,5-dimethoxy-benzylamino]- pyrrolidin-2-one; 3-[4-(Naphthalen-l-ylmethoxy)-3,5"dimethyl-benzylamino]-pyrrolidin- 2-one; 3-[4-(2-Fluorobenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(2-Fluorobenzyloxy)-benzylamino]-N-methylpyrrolidin-2-one; 3-[4-(2-triFluoromethyl-benzyloxy)-benzylamino]-pyrrolidin-2-one; 3 - [4-(2-Chlorobenzyloxy)-benzylamino] -pyrrolidin-2-one; 3-[4-(2-Methoxyben2yloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3-FlTJorobenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3-Fluorobenzyloxy)-benzylamino]-N-methylpyrrolidin-2-one; 3-{N-[4-(3-Fluorobenzyloxy)-benzyl]-N-metb.yl}-amino-pyrrolidin-2- one; 3-[4-(3-triFluoromethyl-benzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3-Chlorobenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3-Methoxybenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3-Methoxyben2yloxy)-benzylamino]-N-methylpyrrolidin-2-one; 3-[4-(4-Fluorobenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(4-Chlorobenzyloxy)-benzylamino]-pyrrolidin-2-one; 3. [4-(4-Methoxybenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(2,3-diChlorobenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diMethoxybenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-benzylamino]-N-methylpyrrolidin-2- one; 3-[4-(3,5-diMethoxyphenyl)-pentoxy]-benzylamino-pyrrolidin-2-one; 3-[4-(2-Fluorobenzyloxy)-3-raethyl-benzylamino]-pyrrolidin-2-one; 3-[4-(2-triFluoromethyl-benzyloxy)-3-methyl-benzylamino]-pyrrolidin- 2-one; 3-[4-(3-Fluorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-{[4-(3-Fluorobenzyloxy)-3-methyl-benzyl]-N-methylamino}- pyrrolidin-2-one; 3-[4-(3-triFluoromethyl-benzyloxy)-3-methyl-benzylamino]-pyrrolidin- 2-one; 3-[4-(3-Chlorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-{[4-(3-Chlorobenzyloxy)-3-methyl-benzyl]-N-methylamino}- pyrrolidin-2-one; 3-[4-(3-Bromobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-{[4-(3-Bromobenzyloxy)-3-methyl-benzyl]-N-methylamino}- pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-2-chloro-benzylamino]-pyrrolidin- 2-one; 3-[4-(4-Fluorobenzyloxy)-3-methyI-benzylamino]-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3-fluoro-ben2ylamino]-pyrrolidin- 2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3-bromo-benzylamino]-pyrrolidin- 2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3-methoxy-benzylamino]- pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3-methyl-benzylamino]-pyrrolidin- 2-one; 3-[4-(4-Chlorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3-bromo-5-methoxy-benzylamino]- pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3,5-dimethoxy-benzylamino]- pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3,5-dimethyl-benzylamino]- pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-2-chloro-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3-fluoro-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3-bromo-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3-methoxy-benzylamino]-pyrrolidin-2- one; 3-[4-(3,4-diChlorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-2-chloro-benzylamino]-pyrrolidin-2- one; 3-[4-(3,5-diMethoxybenzyloxy)-3-fluoro-benzylamino]-pyrrolidin-2- one; 3-[4-(3,5-diMethoxybenzyloxy)-3-bromo-benzylamino]-pyrrolidin-2- one; 3-[4-(3,5-diMethoxybenzyloxy)-3-methoxy"benzylamino]-pyrrolidin-2- one; 3-[4-(3,5-diMethoxybenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2- one; 3-[4-(3,4-diChlorobenzyloxy)-3,5-dimethoxy-ben2ylamino]-pyrrolidin- 2-one; 3-[4-(3,4-diChlorobenzyloxy)-3,5-dimethyl-benzylamino]-pyrrolidin-2- one; 3-[4-(3,5-diChlorobenzyloxy)-3-bromo-5-methoxy-ben2ylamino]- pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-3-bromo-5-methoxy-benzylamino]- pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-3,5-dimethoxy-benzylamino]- pyrrolidin-2-one; 3-[4-(3,5-diMethoxyphenyl)-allyloxy)-3,5-dimethoxy-benzylamino]- pyrrolidin-2-one. 3-(4-Benzyloxy-benzylamino)-piperidin-2-one; 3-(4-Benzyloxy-benzylamino)-azepan-2-one; 3.[4_(2-Fluorobenzyloxy)-benzylamino]-piperidin-2-one; 3-[4-(2-Fluorobenzyloxy)-benzylamino]-azepan-2-one; 3-[4-(2-Chlorobenzyloxy)-benzylamino]-piperidin-2-one; 3-[4-(2-Chlorobenzyloxy)-benzylamino]-azepan-2-one; 3-[4-(3-Fluorobenzyloxy)-benzylamino]-piperidin-2-one; 3 -[4-(3 -Fluorobenzyloxy)-benzylamino] -azepan-2-one; 3.[4.(4_Fluorobenzyloxy)-benzylamino]-piperidin-2-one; 3"[4-(4-Flubrobcnzyloxy)-benzylamino]-azepan-2-one; 3-[4-(2-Cblorobenzylamino)-benzylamino]-piperidin-2-one; 3-[4-(2-Chlorobenzylamino)-benzylamino]-azepan-2-one; 3-{4-[(2-Chlorobenzyl)methylamino]-benzylamino}-piperidin-2-one; 3-{4-[(2-Chlorobenzyl)methylamino]-benzylamino}-azepan-2-one; 3-(4-Phenoxybenzylamino)-pyrroIidin-2-one; or pharmaceutically acceptable salts thereof. The compounds of the invention and the salts thereof can be obtained by a process comprising: a) reaction of compounds of formula II (Figure Remove) CHO II wherein R1, R2, R3 and X are as defined above with compounds of formula III, in the presence of a reducing agent (Figure Remove) in wherein m and R5 are as defined previously thus obtaining a compound of formula I; or b) reaction of compounds of formula IV (Figure Remove) CHjY IV wherein R1, R2, R3 and X are as defined above and Y is a halogen atom or a O-EWG group, where the EWG means an electron withdrawing group, like e.g. mesyl, tosyl or trifluoroacetyl groups, able to transform the oxygen which they are linked to, in a good leaving group with compounds of formula III thus obtaining a compound of formula I; or c) reacting of a compound of formula V (Figure Remove) V wherein R1, R2, R3, R5, X and m are as defined above, with compounds of formula VI or VII R4-Y R7-CHO VI VII wherein Y is as defined above; R4 is as above defined and R7 is hydrogen or Ci-C5 alkyl; and, if desired, converting a compound of the invention into another compound of the invention and/or, if desired, converting a compound of the invention into a pharmaceutically acceptable salt and/or, if desired, converting a salt into a free compound and/or, if desired, separating a mixture of isomers of compounds of the invention into a single isomer. Compounds II, III, IV, VI and VII are commercially available compounds or are prepared from commercially available compounds using well-known methods. The reactions of compounds of formula II with compounds of formula III and of compounds of formula V with compounds of formula VII to give the compounds of formula I is a reductive animation reaction which can be carried out according to known methods. According to a preferred embodiment of the invention, it may be performed under nitrogen atmosphere, in a suitable organic solvent, such as an alcohol, e.g. a lower alkanol, in particular methanol, or in acetonitrile, or in tetrahydrofuran, at a temperature ranging from about 0°C to about 70°C, in the presence of a reducing agent, the most appropriate being sodium borohydride or sodium cyanoborohydride. Occasionally Titanium IV isopropylate and molecular sieves can be added to the reaction mixture for facilitating the reaction. In a compound of formula IV and VI the halogen is preferably bromine or iodine. The alkylation reactions of a compound of formula IV with a compound of formula III and of a compound of formula V with a compound of formula VI can be carried out in a suitable organic solvent, such as an alcohol, e.g. methanol, ethanol or isopropanol, in particular hi ethanol, at a temperature ranging from about 0°C to about 50°C. When in the compounds of the present invention and in the intermediate-products thereof, groups are present, which need to be protected before submitting them to the above illustrated reactions, they may be protected before being reacted and then deprotected according to well-known methods, PHARMACOLOGY The compounds of the invention display affinities for the calcium and/or sodium channel binding sites as demonstrated using selective radioligands in in vitro binding studies. The compounds according to the invention are blockers of the voltage dependent sodium channels and/or calcium channels. These compounds therefore displace 3H-batrachotoxin (BTX) with a high affinity from the binding site on the sodium channel, with ICjo in the low pM or sub \iM range. Similarly the compounds displace 3H-nitrendipine from the binding site in the calcium channel, with IC50 in the low uM or most usually in the sub uJM range as well as inhibiting calcium influx induced through calcium channels via cellular depolarisation. Such substances exhibit "use-dependency" when the sodium channels are blocked i.e. maximum blockage of the sodium channels is only achieved after repeated stimulation of the sodium channel. Consequently, the substances preferably bind to sodium channels which are multiply activated. As a result the substances are capable of activity preferentially in those regions of the body which are pathologically over-stimulated, as illustrated by patch-clamp experiments (W.A. Catteral, Trends Pharmacol. Sci., 8, 57-65; 1987) which show that the compounds according to the invention block the electrically stimulated sodium channel in a "use-dependent" manner. The compounds of the invention are voltage dependent blockers of the calcium and/or sodium channels as demonstrated by fluorescence calcium influx assay and electrophysiological studies. The N-type calcium channel modulating activity of the 3-aminopyrrolidone derivatives of general formula I was measured through a fluorescence based calcium influx assay. The sodium channel modulating activity of the 3-aminopyrrolidone derivatives of general formula I was measured through electrophysiological assays using the two electrodes voltage clamp (TEVC) technique in isolated Xenopus oocytes expressing the Na channel Navl.3. As a consequence of these mechanisms the compounds of the invention are active in vivo when orally administered in the range of 0.1 to 100 mg/kg in animal models such as the formalin model of persistent pain and the carragenan model of inflammation. In view of the above described mechanisms of action, the compounds of the present invention are useful in the treatment or prevention of neuropathic pain. Neuropathic pain syndromes include, and are not limited to: diabetic neuropathy; sciatica; non-specific lower back pain; multiple sclerosis pain; fibromyalgia; HIV-related neuropathy; neuralgia, such as post-herpetic neuralgia and trigeminal neuralgia; and pain resulting from physical trauma, amputation, cancer, toxins or chronic inflammatory conditions. Compounds of the invention are also useful for the treatment of chronic pain. Chronic pain includes, and is not limited to, chronic pain caused by inflammation or an inflammatory-related condition, ostheoarthritis, rheumatoid arthritis, acute injury or trauma, upper back pain or lower back pain (resulting from systematic, regional or primary spine disease (such as radiculopathy), bone pain, pelvic pain, spinal cord injury-associated pain, cardiac chest pain, non-cardiac chest pain, central post-stroke pain, myofascial pain, cancer pain, geriatric pain or pain caused by headache, temporomandibular joint syndrome, gout, fibres is or thoracic outlet syndromes. In particular rheumatoid arthritis and ostheoarthritis. Compounds of the invention are also useful in the treatment of acute pain (caused by acute injury, illness, sports-medicine injuries, carpal tunnel syndrome, burns, musculoskeletal sprains and strains, musculotendinous strain, cervicobrachial pain syndromes, dyspepsis, gastric ulcer, duodenal ulcer, dysmenorrhea, endometriosis or surgery (such as open heart or bypass surgery), post operative pain, kidney stone pain, gallbladder pain, gallstone pain, obstetric pain or dental pain. Compounds of the invention are also useful in the treatment of migraine, such as tension type headache, transformed migraine or evolutive headache, cluster headache, as well as secondary headache disorders, such as the ones derived from infections, metabolic disorders or other systemic illnesses and other acute headaches, paroxysmal hemicrania and the like, resulting from a worsening of the above mentioned primary and secondary headaches. Compounds of the invention are also useful for the treatment of cognitive disorders. Compounds of the invention are also useful for the treatment of psychiatric disorders. Psychiatric disorders include, and are not limited to, bipolar disorder (such as bipolar disorder type I, bipolar disorder type II), cyclothymia disorder, rapid cycling, ultradian cycling, mania, hypomania, schizophrenia, schizophreniform disorders, schizoaffective disorders, delusional disorders, brief psychotic disorders, shared psychotic disorders, psychotic disorder due to a general medical condition, substance-induced psychotic disorders or a psychotic disorder not otherwise specified, anxiety disorders and moreover in smoke and drug addiction. In particular bipolar disorders, psychosis and addiction. Compounds of the invention are also useful in the treatment of peripheral diseases such as tinnitus. Compounds of the invention inhibit inflammatory processes affecting all body systems. Therefore are useful in the treatment of inflammatory processes of the muscular-skeletal system of which the following is a list of examples but it is not comprehensive of all target disorders: arthritic conditions such as aikylosing spondylitis, cervical arthritis, fibromyalgia, gut, juvenile rheumatoid arthritis, lumbosacral arthritis, osteoarthritis, osteoporosis, psoriatic arthritis, rheumatic disease; disorders affecting skin and related tissues: eczema, psoriasis, dermatitis and inflammatory conditions such as sunburn; disorders of the respiratory system: asthma, allergic rhinitis and respiratory distress syndrome, lung disorders in which inflammation is involved such as asthma and bronchitis; chronic obstructive pulmonary disease; disorders of the immune and endocrinological systems: periarthritis nodosa, thyroiditis, aplastic anaemia, sclerodoma, myasthenia gravis, multiple sclerosis, sarcoidosis, nephritic syndrome, Bechet's syndrome, polymyositis, gingivitis. Compounds of the invention are also useful in the treatment of gastrointestinal (GI) tract disorders such as inflammatory bowel disorders including but not limited to ulcerative colitis, Crohn's disease, ileitis, proctitis, celiac disease, enteropathies, microscopic or collagenous colitis, eosinophilic gastroenteritis, or pouchitis resulting after proctocolectomy and post ileonatal anastomosis, and irritable bowel syndrome including any disorders associated with abdominal pain and/or abdominal discomfort such as pylorospasm, nervous indigestion, spastic colon, spastic colitis, spastic bowel, intestinal neurosis, functional colitis, mucous colitis, laxative colitis and functional dyspepsia; but also for treatment of atrophic gastritis, gastritis varialoforme, ulcerative colitis, peptic ulceration, pyresis, and other damage to the GI tract, for example, by Helicobacter pylori, gastroesophageal reflux disease, gastroparesis, such as diabetic gastroparesis; and other functional bowel disorders, such as non-ulcerative dyspepsia (NUD); emesis, diarrhea, and visceral inflammation. Compounds of the invention are also useful in the treatment of disorders of the genito-urinary tract such as overactive bladder, prostatitis (chronic bacterial and chronic non-bacterial prostatitis), prostadynia, interstitial cystitis, urinary incontinence and benign prostatic hyperplasia, annexities, pelvic inflammation, bartoUnities and vaginitis. In particular overactive bladder and urinary incontinence. Compounds of the invention are also useful in the treatment of ophthalmic diseases such as retinitis, retinopathies, uveitis and acute injury to the eye tissue, macular degeneration or glaucoma, conjunctivitis. Compounds of the invention are also useful in the treatment of obesity. Compounds of the invention are also useful for the treatment of all other conditions mediated by the inhibition of voltage gated sodium channels and/or voltage gated calcium channels. It will be appreciated that the compounds of the invention may advantageously be used in conjunction with one or more other therapeutic agents. Examples of suitable agents for adjunctive therapy include a 5HTiB/]D agonist, such as a triptan (e.g. sumatriptan or naratriptan); an adenosine Al agonist; an EP ligand; an NMDA modulator, such as a glycine antagonist; a substance P antagonist (e.g. an NK1 antagonist); a cannabinoid; acetaminophen or phenacetin; a 5-lipoxygenase inhibitor; a leukotriene receptor antagonist; a DMARD (e.g. methotrexate); gabapentin and related compounds; a tricyclic antidepressant (e.g. amitryptiline); a neurone stabilising antiepileptic drug; a monoaminergic uptake inhibitor (e.g. venlafaxine); a matrix metalloproteinase inhibitor; a nitric oxide synthase (NOS) inhibitor, such as an iNOS or an nNOS inhibitor; an inhibitor of the release, or action, of tumor necrosis factor alpha; an antibody therapy, such as monoclonal antibody therapy; an antiviral agent, such as a nucleoside inhibitor (e.g. (lamivudine) or an immune system modulator (e.g. interferon); an analgesic, such as a a cyclooxygenase-2 inhibitor; a local anaesthetic; a stimulant, including caffeine; an H2-antagonist (e.g. ranitidine); a proton pump inhibitor (e.g. omeprazole); an antacid (e.g. aluminium or magnesium hydroxide; an antiflatulent (e.g. semethicone); a decongestant (e.g. phenylephrine, phenylpropanolamine, pseudoephedrine, oxymetazoline, epinephrme, naphazoline, xylometazoline, propylhexedrine, or levo-desoxyephedrine,naphazoline, xylometazoline, propylhexedrine, or levo-desoxyephedrine); antitussive (e.g. codeine, hydrocodone, carmiphen, carbetapentane, or dextramethorphan); a diuretic; or a sedating or non-sedating antihistamine. It is to be understood that the present invention covers the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in combination with one or more therapeutic agents. The compounds of the present invention are useful in human and veterinary medicine. It is to be understood that reference to treatment includes both treatments of established symptoms and prophylactic treatment, unless explicitly stated otherwise. The 3-aminopyrrolidone derivatives of formula I as above defined can be administered as the "active ingredient" of a pharmaceutically acceptable composition which can be prepared by conventional procedures, for instance by mixing the active ingredient with pharmaceutically acceptable, therapeutically inert organic and/or inorganic carrier materials. The composition comprising the above defined 3-aminopyrrolidone derivatives can be administered in a variety forms, e.g. orally, in the form of tablets, troches, capsules, sugar or film coated tablets, liquid solutions, emulsions or suspensions; rectally, in the form of suppositories; parenterally, e.g. by intramuscular or intravenous injection or infusion; and transdermally. Suitable pharmaceutically acceptable, therapeutically inert organic and/or inorganic carrier materials useful in the preparation of such composition include, for example, water, gelatin, gum arabic, lactose, starch, cellulose, magnesium stearate, talc, vegetable oils, polyalkyleneglycols and the like. The composition comprising the 3-aminopyrrolidone derivatives of formula I as above defined can be sterilized and may contain further well known components, such as, for example, preservatives, stabilizers, wetting or emulsifying agents, e.g. paraffin oil, mannide monooleate, salts to adjust osmotic pressure, buffers and the like. For example, the solid oral forms may contain, together with the active ingredient, diluents, e.g. lactose, dextrose, saccharose, cellulose, corn starch or potato starch; lubricants, e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols; binding agents, e.g. starches, arabic gums, gelatin, methylcellulose, carboxymethylcellulose or polyvinyl pyrrolidone; disgregating agents, e.g. a starch, alginic acid, alginates or sodium starch glycolate; effervescing mixtures; dyestuffs; sweeteners; wetting agents such as lecithin, polysorbates, laurylsulphates; and, in general, non-toxic and pharmacologically inactive substances used in pharmaceutical formulations. Said pharmaceutical preparations may be manufactured in known manner, for example, by means of mixing, granulating, tabletting, sugar-coating, or film-coating processes. The oral formulations comprise sustained release formulations that can be prepared in conventional manner, for instance by applying an enteric coating to tablets and granules. The liquid dispersion for oral administration may be e.g. syrups, emulsions and suspensions. The syrups may contain as carrier, for example, saccharose or saccharose with glycerine and/or mannitol and/or sorbitol. Suspensions and emulsions may contain as a carrier, for example, a natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethyl-cellulose, or polyvinyl alcohol. The suspensions or solutions for intramuscular injections may contain, together with the active compound, a pharmaceutically acceptable carrier, e.g. sterile water, olive oil, ethyl oleate, glycols, e.g. propylene glycol, and, if desired, a suitable amount of lidocaine hydrochloride. The solutions for intravenous injections or infusion may contain as carrier, for example, sterile water or preferably they may be in the form of sterile, aqueous, isotonic saline solutions. The suppositories may contain, together with the active ingredient, a pharmaceutically acceptable carrier, e.g. cocoa butter, polyethylene glycol, a polyoxyethylene sorbitan fatty acid ester surfactants or lecithin. Suitable treatment is given 1, 2 or 3 times daily, depending upon clearance rate. Accordingly, the desired dose may be presented in a single dose or as divided doses administered at appropriate intervals, for example two to four or more sub-doses per day. The pharmaceutical compositions comprising the 3-aminopyrrolidone derivatives of formula I as above defined will contain, per dosage unit, e.g., capsule, tablet, powder injection, teaspoonful, suppository and the like from about 0.1 to about 500 mg of the active ingredient most preferably from 1 to 10 mg. Optimal therapeutically effective doses to be administered may be readily determined by those skilled in the art and will vary, basically, with the strength of the preparation, with the mode of administration and with the advancement of the condition or disorder treated. In addition, factors associated with the particular subject being treated, including subject age, weight, diet and time of administration, will result in the need to adjust the dose to an appropriate therapeutically effective level. The following examples further illustrate the invention. Example 1 (S)-3-[4-(3-Fluorobenzyloxy)-benzylamino]-pyrrolidin-2-one To a 2M solution of (S)-3-aminopyrrolidin-2-one (1.47 g, 14.6 mmol), prepared as described in Example 5, in anhydrous methanol 2.0 g of 3 A molecular sieves and 0.77 g NaBH3CN (12 mmol)were added; after 10 minutes, 3.4 g (14.8 mmol) of 4-(3-fluorobenzyloxy)benzaldeyde in 40 ml of anhydrous methanol were added. The reaction was carried out for 3 hours, then the mixture filtered, the solution was evaporated yielding a residue which was directly flash-chromatographed on silica gel (eluant: CHC13:CH3OH:NH3 dropwise and the reaction mixture was stirred 12 hours at room temperature under nitrogen. A 0.75M solution of sodium borohydride (690 mg, 18.2 mmol) in absolute ethanol was added and the resulting mixture was heated at 70°C for 6 hours. After cooling, water (8 ml) was added and the resulting white precipitate was removed by filtration. The crude compound was purified using SCX cartridge (Strong Cation eXchange resin). The pure product was recovered by eluting with 3% ammonia solution in methanol. The title compound was obtained (2.24 g) after evaporating the solvent under vacuum with a yield of 88%. MS (ESI Pos Spray 3.5 kV; Skimmer 20 V; Probe 250°C): 393 [MH+] 'H-NMR (DMSO-d6) 5: 7.7 (m, 5H), 7.0 (s, 2H), 4.9 (s, 2H), 3.68 (s, 2H), 3.15 (m, 3H), 2.22 (m, 7H), 1.7 (m, 1H). Example 4 (S)-3-[4-(3,4-Dichloro-benzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one 2M solution of (S)-3-amino-pyrrolidin-2-one (650 mg, 6.5 mmol), prepared as described in Example 5, in dry THF was added to a 1M solution of 4-(3,4-dichloro-benzyloxy)-3-methyl-benzaldehyde (2.1 g, 7.15 mmol), prepared as described in Example 7, in dry THF. To this mixture, a 2M solution of TKO-iPRO (2.77 g, 9.75 mmol) in dry THF was added dropwise and the reaction mixture was stirred 12 hours at room temperature under nitrogen. A 0.75M solution of sodium borohydride (690 mg, 18.2 mmol) in absolute ethanol was added and the resulting mixture was heated at 70°C for 6 hours. After cooling, water (8 ml) was added and the resulting white precipitate was removed by filtration. The crude compound was purified using SCX cartridge (Strong Cation eXchange resin). The pure product was recovered by eluting with 3% ammonia solution in methanol. The title compound was obtained (2.18 g) after evaporating the solvent under vacuum with a yield 89%. MS (ESI Pos Spray 3.5 kV; Skimmer 20 V; Probe 250°C): 378.9 [MH+] 'H-NMR (DMSO-d6) 8: 7.72-7.68 (m, 3H), 7.45 (dd, 1H), 7.1 (m, 2H), 6.9 (dd, 1H), 5.15 (s, 2H), 3.65 (s, 2H), 3.15 (m, 3H), 2.20 (m, 4H), 1.68 (m, 1H). Example 5 (S)-3-amino-pyrrolidin-2-one 5M solution of hexamethyldisilazane (108 ml, 523 mmol) in CH3CN was added dropwise to a solution of (S)-2,4-diamino-butyric acid (10 g, 52.3 mmol) in CHaCN (150 ml) at room temperature. The resulting mixture was refluxed for 30 hours. The crude reaction was poured into cold MeOH (400 ml), stirred at room temperature for 30 minutes and then evaporated under vacuum. The resulting solid was dissolved in CH2Cl2 (700 ml) and the insoluble residue was removed by filtration under vacuum. The title compound was obtained (3.13 g) after evaporating the solution to dryness in a 60% yield. Example 6 3,5-DimethyI-4-(4-trifluoromethyl-benzyloxy)-benzaldehyde 0.5M solution of l-bromomethyl-4-trifluoromethyl-benzene (1.9 g, 8.0 mmol) in DMF was added dropwise to a suspension of 4-hydroxy-3,5-dimethyl-benzaldehyde (930 mg, 7.3 mmol), K2CO3 (1.51 g, 11 mmol) and KI (120 mg, 0.73 mmol) in DMF (100 ml). The reaction mixture was stirred at 90°C overnight. After cooling, the solid residue was filtered off and the solvent was evaporated under vacuum. The residue was dissolved in ethyl acetate and the organic layer washed twice with NaOH 1M, dried over Na2SO4 and evaporated to dryness. The residue was purified on silica gel, obtaining 2.24 g of the title compound in a quantitative yield. Example? 4-(3,4-diChIoro-benzyloxy)-3-methyl-benzaldehyde 0.5M solution of 4-chloromethyl-l,2-dichloro-benzene (1.55 g, 8.0 mmol) in DMF was added dropwise to a suspension of 4-hydroxy-3-methyl-benzaldehyde (990 mg, 7.3 mmol), K2CO3 (1.51 g, 11 mmol) and KI (120 mg, 0.73 mmol) in DMF (100 ml). The reaction mixture was treated as described in Example 6. The residue was purified on silica gel, obtaining 2.15 g of the title compound in a quantitative yield. Example 8 In vitro binding of 3H-batrachotoxin in rat brain membranes Membrane preparations (P2 fraction) Male Wistar rats (Harlan, Italy -175-200 g) were sacrificed under light anaesthesia and brains were rapidly removed and cortex was dissected out, homogenized in 10 vol. of ice-cold 0.25 M sucrose buffer (50 mM Tris-HCl, pH 7.4). The crude homogenate was centrifuged at 3250 rpm for 10 min and the supernatant recovered. The pellet was homogenized and centrifuged again and the two supematants were pooled and centrifuged at 14750 rpm for 10 min, +4°C. The resulting pellet was stored at -20°C until use. Binding assay. The pellet was resuspended in 50 mM Hepes buffer, pH 7.4 containing 0.8 mM MgSO4, 5.4 mM KCI, 5.5 mM glucose and 130 mM choline using Polytron PT10. The binding assay was carried out in 0.25 ml final volume containing 50 ui of membrane preparation (ca 200 ug of protein), 50 ul of 3H-batrachotoxin ligand (10 nM), 50 ul of TTX (1 uM), 50 ul of scorpion toxin (37.5 ug/ml) and 50 ul of test compound or buffer or 300 uM of veratridine to determine non specific binding. The binding assay was performed at 37°C for 30 min and stopped by rapid filtration under vacuum through Whatman GF/B glass fiber filters. Filters (pre-soaked with polyethylenimine 0.1%) were washed with 3x5 ml of ice-cold buffer and placed in picovials containing scintillation cocktail (Filter Count, Packard). Radioactivity bound was measured by liquid scintillation spectrometry at 45% efficiency. Data analysis. The IC50 was calculated from displacement curves by computer program LIGAND (McPherson, J. Pharmacol. Methods, 14, 213. 1985). The displacement curves were obtained using at least 9 concentrations, each hi duplicate, covering a 100000 fold range. Example 9 In vitro binding of 3H-nitrendipine in rat brain membranes Membrane preparations Male Wistar rats (Harlan, Italy - 175-200 g) were sacrificed under light anaesthesia and brains were rapidly removed and cortex was dissected out, homogenized in 10 vol. of ice-cold 50 mM Tris»HCl, pH 7.7 using Polytron PT10. The crude homogenate was centrifuged at SOOOOxg for 10 min. The pellet was homogenized and centrifuged twice in fresh buffer at SOOOOxg for 10 min, +4°C. The resulting pellet was stored at -20°C until use. Bindine assay. The pellet was resuspended in 50 mM Tris«HCl, pH 7.7 using Polytron PT10. The binding assay was carried out in 1 ml final volume containing 900 \n\ of membrane preparation (ca 700 |j.g of protein), 50 \n\ of 3H-nitrendipine (0.15 nM), and 50 \il of test compound or buffer or 1 uM of nifedipine to determine non specific binding. The binding assay was performed at 25°C for 45 min and stopped by rapid filtration under vacuum through Whatman GF/B glass fiber filters. Filters were washed with 3x5 ml of ice-cold buffer and placed hi picovials containing scintillation cocktail (Filter Count, Packard). Radioactivity bound was measured by liquid scintillation spectrometry at 45% efficiency. Data analysis. The ICjo was calculated from displacement curves by computer program LIGAND (McPherson, J. Pharmacol. Methods, 14, 213. 1985). The displacement curves were obtained using at least 9 concentrations, each in duplicate, covering a 100000 fold range. Example 10 Calcium influx assay IMR32 human neuroblastoma cells constitutively possess both L and N type channels. Under differentiating conditions, IMR32 preferentially express on the membrane surface N- type calcium channels. The remaining L-type calcium channels were blocked using the selective L type blocker, nifedipine. In these experimental conditions, only N type channels can be detected. IMR32 cells were differentiated using 1 mM dibutyrril-cAMP and 2.5 uM bromodeoxyuridine for 8 days (4 times) in 225 cm2 flask, then detached, seeded at 200,000 cells/well on 96 polilysine-coated plates and further incubated for 18-24 h in the presence of differentiating buffer before use. The Ca2+ Kit Assay (Molecular Devices), based on a fluorescent calcium indicator 485-535 nm wawelength, was used. Differentiated cells were incubated with dye loading for 30 min at 37°C then, nifedipine alone (1 uM) or in the presence of oo-conotoxin or test compounds were added for further 15 min. The fluorescence (485-535nm) was measured before and after (30-40 sec) the automated injection of 100 mM KCI depolarizing solution using a Victor plate reader (Perkin Elmer). The inhibition curves were calculated from 5 concentrations, each in triplicate, and the ICJO determined using a linear regression analysis. Preferred compounds of general formula 1 inhibit N-type calcium channels with an IC50 value less than 10 uM. Example 11 Electrophysiological assay Experiments for the determination of the tonic block are carried out on isolated Xenopus oocytes expressing the Na channel Navl.3. Currents are recorded using the two electrodes voltage clamp (TEVC) technique. Oocvtes preparation: The frog (Xenopus Laevis) is anesthesized in a solution with 3-aminobenzoic acid ethyl ester (1 g/1) and, after 25 minutes, it is placed on its back on an "iced-bed". The skin and the others tissues are cut, the ovarian lobes are pulled out and kept hi ND960Ca2+ (NaCl 96 mM, KC1 2 mM, MgC12 1 mM, Hepes 10 mM, pH 7.85 withNaOH). After the removal of the oocytes, the muscle and the skin are sutured separately. Ovarian lobes are reduced into clusters of 10/20 oocytes, put in tubes with collagenase solution (1 mg/ml) and kept in movement for about 1 h in an incubator. At the end of this step, when the oocytes are well separated ones from the others, they are rinsed three times with ND960Ca2+and three times with NDE (ND960Ca2+ + CaCl 0.9 mM, MgC12 0.9 mM, piruvate 2.5 mM, gentamicine 50 mg/1). The oocytes obtained are at different stages of development. Only cells at stages V or VI are selected for RNA injection subsequent experiments. The day after the preparation, the oocytes are injected (Drummond Nanoject) with 20 ng Navl.3 cRNA and maintained in NDE. Starting from 48h after the mRNA injection whole cell currents are recorded using a two-microelectrode voltage clamp automated workstation. Typical Microelectrodes have a resistance of 0.5 to 1 Mohm and are filled with KC1 3M. Control bath solution contains (mM): NaCl 98, MgCl2 1, CaCl2 1.8, HEPES 5 (pH 7.6). Compounds are prepared in stock solutions (20 mM) and dissolved to the final concentrations in the external bath solution. Currents recording: The current/voltage (I/V) relationship for the Navl.3 currents expressed in oocytes was first studied in order to determine the membrane potential evoking the maximal activation. Navl.3 showed the max activation at 0 mV, that we used as test potential (Vtest) for tonic block studies. The steady - state inactivation properties of the Navl.3 currents were than studied in order to determine the membrane potentials for the resting state (Vrest) at which channel availability is maximal (Imax), and the membrane potential for the half maximal inactivation (V Vi) producing half of the max current availability (I '/z) respectively. This two voltage conditions were then used for the evaluation of the voltage dependence of the tonic block. Finally a two-step protocol was used to determine the voltage dependence of the block of Navl.3: the oocytes were clamped at -80 raV, the currents were activated by a 100 ms step pulse to 0 mV (Vtest) from a 3000 ms preconditioning potential at -80 mV (resting, Imax condition) and -40 mV (depolarized, I V£ condition), respectively. Current amplitudes in the two conditions were recorded hi the absence and in the presence of different concentrations of compound (washout was made hi between) in order to determine the concentration - inhibition curves and ICjo values for the tonic block in the depolarized (half max current availability) conditions. Preferred compounds of general formula I inhibit Navl.3 sodium channels with an IC50 value lower than the reference sodium channel blocker ralfmamide. Example 12 Mice Formalin Test According to a modified protocol from Rosland et al., (1990) mice were injected subcutaneously (s.c.) with 20 ul of 2.1% solution of formalin into the plantar surface of left hindpaw and placed immediately into clear PVC observation chambers (23 x 12 x 13 cm). Pain behaviour was quantified by counting the cumulative licking time (s) of the injected paw. Measurements were taken during the early phase (0-5 min) and late phase (30-40 min) after formalin injection (Tjolsen et al. 1992). The test compound was administered p.o. 15 min before formalin injection in a volume of 10 ml/kg body weight to groups of 10 mice per dose. Control group was treated with vehicle. Example 13 Carragenan model of inflammation Male Wistar rats of 175-200 grams were used. The left hind paw was injected with 100 jil of carrageenan (2% w/v in saline). Compounds of the invention (30 mg/kg), indomethacin (5 mg/kg) or control vehicle (such as distilled water) were orally administered 1 h before carrageenan injection. The paw volume was measured with a plethysmometer (Ugo Basile) immediately before (basal) and 1, 2, 3, 4 and 5h after the carrageenan injection. We Claim: A compound of general formula I: (Formula Removed) wherein m is an integer from 1 to 3 X is methylene, oxygen, sulphur or a NR6 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl or phenyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5, R6 are independently hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof; provided that: - when R1 is phenyl, benzyl, 2-phenethyl or 3-phenpropyl optionally and independently substituted on the phenyl ring by one or two C1-C6 alkyl, halogen, hydroxy, C1-C4 alkoxy or trifluoromethyl and X is oxygen, sulphur, methylene or -NH-, at least one of R2 or R3 is other than hydrogen; - if m is 3, R1-X 4-benzyloxy, R2, R4 and R5 hydrogen then R3 is other than 3-methoxy, and - if m is 3, R1-X 3-benzyloxy, R2, R4 and R5 hydrogen then R3 is other than 4- methoxy; - if m is 3, R2-R5 are hydrogen and X is oxygen, R1 is not ethyl. 2. A compound as claimed in claim 1, selected from the group consisting of: 3-(4-Butyloxy-benzylamino)-pyrrolidin-2-one; 3-[4-(4-trifluorobutyloxy)-benzylamino]-pyrrolidin-2-one; 3-(4-Pentyloxy-benzylamino)-pyrrolidin-2-one; 3-[4-{5-trifluoropentyloxy)-benzylamino]-pyrrolidin-2-one; 3-(4-Phenylbutoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy)-benzylamino-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-benzylamino)-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-benzylamino]-pyrrolidin-2-one; 3-(4-Pentyloxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-{4-Phenylpentoxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-{4-Phenylallyloxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-{4-Phenylallyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-bromo-benzylamino)-pyrrolic!in-2-one; 3-(4-Phenoxyethoxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-melhyl-benzylamino)-pyrrolidin-2-one; 3-{4-(Naphthalen-1-ylmethoxy)-3-bromo-benzylamino]-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3-methoxy-benzylamino]-pyrrolidin-2-one; 3-[4-{Naphlhalen-1-ylmethoxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-(4-Pentyloxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Pentyloxy-3,5-dimethoxy-benzylamino)-pyrrolidin-2-one; 3-{4-Pentyloxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3,5-dimethoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Ben2yloxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Ptienylallyloxy-3,5-dimethoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3-{4-Phenylpentoxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3,5-dimethoxy-benzylamino)-pyrrolidin-2-one; 3-{4-Phenylpentoxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3,5-dimethoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3,5-dimethyl-benzylamino)-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-2-chloro-5-methoxy-benzylaminol-pyrrolidin-2-one; 3-[4-{Naphthalen-1-ylmethoxy)-3-fluoro-5-methoxy-benzylamino]-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3-bromo-5-melhoxy-benzylamino]-pytTolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3,5-dimethoxy-benzylamino]-pyrrolidin-2-one; 3-(4-(Naphthalen-1-ylmethoxy)-3,5-dimethyl-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxyphenyl)-pentoxy]-benzylamino-pyrrolidin-2-one; 3-[4-(2-Fluorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-{2-triFluoromethyl-benzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(3-Fluorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-{[4-(3-Fluorobenzyloxy)-3-methyl-benzyl]-N-methylamino}-pyrrolidin-2-one; 3-[4-(3-triFluoromethyl-benzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(3-Chlorobenzyloxy)-3-methyl-benzylamino]-pyrroliclin-2-one; 3-{l4-(3-Chlorobenzyloxy)-3-methyl-benzyl]-N-methylamino}-pyrrolidin-2-one; 3-I4-{3-Bromobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-{[4-(3-Bromobenzyloxy)-3-methyl-benzyl]-N-methylamino}-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-2-chloro-benzylamino]-pyrrolidin-2-one; 3-[4-(4-Fluorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3-fluoro-benzylamino]-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3-bromo-benzylamino]-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3-methoxy-benzylamino]-pyrrolidin-2-one; 3-[4-{4-triFluoromethyl-benzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(4-Chlorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(4-trifluoromethyl-benzyloxy)-3-bromo-5-methoxy-benzylamino]-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3,5-dimethoxy-benzylamino]-pyrrolidin-2-one; 3-[4-(4-triFluoromethyl-benzyloxy)-3,5-dimethyl-benzylaminol-pyrrolidin-2-one; 3-[4-{3,4-diChlorobenzyloxy)-2-chloro-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3-fluoro-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3-bromo-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3-methoxy-benzylaminol-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-2-chloro-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-3-fluoro-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-3-bromo-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-3-methoxy-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3,5-dimethoxy-benzylamino]-pyrrolidin-2-one; 3-[4-(3,4-diChlorobenzyloxy)-3,5-dimethyl-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diChlorobenzyloxy)-3-bromo-5-methoxy-benzylamino]-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-3-bromo-5-methoxy-benzylaminol-pyrrolidin-2-one; 3-[4-(3,5-diMethoxybenzyloxy)-3,5-dimethoxy-benzylamino]-pyrrolidin-2-one; 3-l4-(3,5-diMelhoxyphenyl)-allyloxy)-3,5-dimethoxy-benzylamino]-pyrrolidin-2-one. or pharmaceutically acceptable salts thereof. 3. The compound as claimed in claim 1 or 2, whenever used for the preparation of a medicament for the treatment of pain, migraine, cognitive disorders, inflammation, gastrointestinal tract disorders, disorders of the genitor-urinary tract, ophthalmic diseases, obesity. 4. A process for the preparation of a compound as claimed in claim 1, or a pharmaceutically acceptable salt thereof, the process comprising: a) reaction of compounds of formula II (Formula Removed) wherein R1, R2, R3 and X are as defined in claim 1 with compounds of formula III, in the presence of a reducing agent (Formula Removed) wherein m and R5 are as defined previously thus obtaining a compound of formula I; or b) reaction of compounds of formula IV (Formula Removed) wherein R1, R2, R3 and X are as defined above and Y is a halogen atom or a O-EWG group, where the EWG means an electron withdrawing group, like e.g. mesyl, tosyl or trifluoroacetyl groups, able to transform the oxygen which they are linked to, in a good leaving group with compounds of formula III thus obtaining a compound of formula I; or c) reacting of a compound of formula V (Formula Removed) wherein R1, R2, R3, R5, X and m are as defined above, with compounds of formula VI or VII (Formula Removed) wherein Y is as defined above; R4 is as above defined and R7 is hydrogen or C1-C5 alkyl; and, if desired, converting a compound of the invention into another compound of the invention and/or, if desired, converting a compound of the invention into a pharmaceutically acceptable salt and/or, if desired, converting a salt into a free compound and/or, If desired, separating a mixture of isomers of compounds of the invention into a single isomer.

Documents:

2725-DELNP-2005-Abstract-(12-01-2012).pdf

2725-DELNP-2005-Claims-(12-01-2012).pdf

2725-DELNP-2005-Correspondence Others-(12-01-2012)..pdf

2725-DELNP-2005-Form-3-(12-01-2012).pdf

2725-delnp-2006-abstract.pdf

2725-delnp-2006-assignment.pdf

2725-delnp-2006-claims.pdf

2725-DELNP-2006-Correspondence Others-(12-01-2012).pdf

2725-delnp-2006-Correspondence Others-(13-07-2011).pdf

2725-DELNP-2006-Correspondence Others-(15-07-2011).pdf

2725-delnp-2006-correspondence-others 1.pdf

2725-delnp-2006-description (complete).pdf

2725-delnp-2006-form-1.pdf

2725-delnp-2006-form-18.pdf

2725-delnp-2006-form-2.pdf

2725-delnp-2006-Form-3-(13-07-2011).pdf

2725-delnp-2006-form-3.pdf

2725-delnp-2006-form-5.pdf

2725-delnp-2006-pct-304.pdf

2725-delnp-2006-pct-306.pdf

2725-delnp-2006-pct-request form.pdf

2725-delnp-2006-pct-search report.pdf

2725-DELNP-2006-Petition-137-(12-01-2012).pdf