Title of Invention	SYNTHESIS OF BIS (THIO-HYDRAZIDE AMIDE) SALTS
Abstract	A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tertbutyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide). In some embodiments, a method of preparing a bis(thiohydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl tert-bvtyl ether to precipitate the disalt of the bis(thiohydrazide amide). The disclosed methods do not require lyophylization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation.

Title of Invention

SYNTHESIS OF BIS (THIO-HYDRAZIDE AMIDE) SALTS

Abstract

A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tertbutyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide). In some embodiments, a method of preparing a bis(thiohydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl tert-bvtyl ether to precipitate the disalt of the bis(thiohydrazide amide). The disclosed methods do not require lyophylization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation.

Full Text	SYNTHESIS OF BIS(TfflO-HYDRAZE)E AMIDE) SALTS RELATED APPLICATION This application claims the benefit of U.S. Provisional Application No. 60/681,263, filed on May 16,2005. The entire teachings of the above application are incorporated herein by reference. BACKGROUND OF THE INVENTION Certain bis(thio-hydrazide amide) compounds are useful as Pharmaceuticals, in particular, as anticancer agents. See, for example Chen, et al., U.S. Patent No. 6,825,235, U.S. Published Patent Application No. 20040229952; U.S. Patent Nos. 6,762,204 and 6,800,660 to Koya, et al, and U.S. Published Patent Application Nos. 20050009920,20040235909,20040225016, and 20030195258. The entire teachings of these documents are incorporated by reference. Salts of these bis(thio-hydrazide amide) compounds are believed to be particularly useful at least in part for reasons of solubility. See, for example Koya, et al., U.S. Provisional Patent Application Serial No. 60/582,596, filed June 23,2004, and U.S. Provisional Patent Application Serial No. not yet assigned, Atty. Docket No. 3211.1014-001, filed concurrently herewith. The entire teachings of these applications are incorporated by reference. However, the existing process includes a lyophilization step, which can be energy intensive and poorly suited to scale up to production runs. Therefore, there is a need for an improved process for preparing salts of bis(thio-hydrazide amide) compounds. SUMMARY OF THE INVENTION It has now been found that bis(thio-hydrazide amide) disalts can be prepared in a process suitable for scale-up to pharmaceutical production runs. A method of preparing a bis(tbio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form abis(thio-hydrazide amide) solution; and combining the solution and methyl to-f-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide). In some embodiments, a method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl rert-butyl ether to precipitate the disalt of the bis(thio-hydrazide amide). The disclosed methods do not require lyophylization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation. DETAILED DESCRIPTION OF THE INVENTION A description of preferred embodiments of the invention follows. The invention is a method of preparing a bis(thio-hydrazide amide) disalt, which includes the steps of combining a neutral bis(tbio-hydrazide amide), an organic solvent and abase to form abis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(tbio-hydrazide amide). Thus, as used herein, a neutral bis(thio-hydrazide amide) has at least two hydrogens which can react with the bases described herein to form a disalt. Typically, at least about two molar equivalents of the base are employed for each molar equivalent of neutral bis(thio-hydrazide amide); more typically, from about 2 to about 5 equivalents, or preferably from about 2.0 to about 2.5 equivalents. Suitable bases can be strong enough to react with a bis(thio-hydrazide amide) to produced a disalt. In various embodiments, the base can be an amine (e.g., triethylamine, diphenylamine, butylamine, or the like); an ammonium hydroxide (e.g., tetramethyammonium hydroxide, tetrabutylammonium hydroxide, or the like); an alkali metal hydroxide (lithium hydroxide, sodium hydroxide, potassium hydroxide, or the like) an alkali metal C1-C6 alkoxide, or an alkali metal amide (e.g., sodium amide, lithium diisopropyl amide, or the like). In some embodiments, the base is sodium hydroxide, potassium hydroxide, sodium C1-C6 alkoxide, potassium C1-C6 alkoxide, sodium amide, or potassium amide, or preferably, sodium hydroxide, sodium methoxide, or sodium ethoxide. In various embodiments, the base can be an alkak' metal hydride (e.g., sodium hydride, potassium hydride, or the like), a divalent metal base (e.g., magnesium oxide)a C1-C6 alkyl alkali metal (e.g., butyllithium), or an aryl alkali metal (e.g., phenyllithium). More typically, the base is lithium hydride, sodium hydride, potassium hydride, butyllithium, butylsodium, butylpotassium, phenyllithium, phenylsodium, or phenylpotassium. As used herein, an alkali metal includes lithium, sodium, potassium, cesium and rubidium. The organic solvent can be any organic solvent which is stable when the base is added to a mixture of the bis(thio-hydrazide amide) and the organic solvent. Typically, the organic solvent is polar enough to dissolve the bis(tbio-hydrazide amide) salt formed by the method to form a solution. In various embodiments, the organic solvent is water-miscible. The organic solvent can generally be selected • from a C1-C4 aliphatic alcohol (e.g., methanol, ethanol, 1-propanol, 2-propanol, or • the like), a C1-C4 aliphatic ketone (e.g., acetone, methyl ethyl ketone, 2-butanone, or the like), a C2-C4 aliphatic ether (e.g., diethyl ether, dipropyl ether, diisopropyl ether, or the like), a C2-C4 cycloaliphatic ether (e.g., tetrahydrofuran, dioxane,), dimethyl formamide, dimethyl sulfoxide, N-methyl pyrrolidone, a glycol (e.g., ethylene glycol, propylene glycol, tetramethylene glycol, or the like), an alkyl glycol ether (e.g., ethylene glycol dimethyl ether, or the like), and acetonitrile. More typically, the organic solvent can be selected from methanol, ethanol, propanol (e.g., 1-propanol, 2-propanol), butanol (e.g., 1-butanol, tert-butyl alcohol, or the like), acetone, tetrahydrofuran, and methyl ethyl ketone. Preferably, the organic solvent can be selected from methanol, ethanol, acetone, and methyl ethyl ketone. In various embodiments, the neutral bis(thio-hydrazide amide) can be substantially insoluble in the organic solvent, thereby forming a mixture, whereby combining the base with the mixture forms abis(thio-hydrazide amide) solution. Typically, the bis(thio-hydrazide amide) solution can be clear. Generally, between about 0.25 and about 2.5 moles of the neutral bis(thio-hydrazide amide) are 34. A method of preparing a bis(thio-hydrazide amide) disalt substantially as herein described with reference to the accompanying specification and examples. We claim: 1. A method of preparing a bis(thio-hydrazide amide) disalt, wherein said method comprises the steps of: Combining a neutral bis(thio-hydrazide amide), wherein the neutral bis(thio-hydrazide amide) is represented by the following Structural Formula: (Formula Removed) an organic solvent selected from a C1-C4 aliphatic alcohol, a C1-C4 aliphatic ketone, a C2-C4 aliphatic ether, a C2-C4 cycloaliphatic ether, dioxane dimethyl formamide, dimethyl sulfoxide, N-methyl pyrrolidone, a glycol, an alkyl glycol ether, dioxane, and acetonitrile and a base selected from an amine; an ammonium hydroxide; an alkali metal hydroxide, an alkali metal C1-C6 alkoxide, or an alkali metal amide, an alkali metal hydride, an alkyl alkali metal, or an aryl alkali metal to form a bis(thio-hydrazide amide) solution; and Combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide). 2. The method as claimed in Claim 1, wherein at least about two molar equivalents of the base are employed for each molar equivalent of neutral bis(thio-hydrazide amide). 3. The method as claimed in Claim 2, wherein the organic solvent is water-miscible. 4. The method as claimed in Claim 1, wherein the organic solvent is selected from methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, tert-butyl alcohol, acetone, tetrahydrofuran, and methyl ethyl ketone. 5. The method as claimed in Claim 4, wherein the organic solvent is selected from methanol, ethanol, acetone, and methyl ethyl ketone. 6. The method as claimed in Claim 1, wherein the base is sodium hydroxide, potassium hydroxide, sodium C1-C6 alkoxide, potassium C1-C6 alkoxide, sodium amide, or potassium amide. 7. The method as claimed in Claim 6, wherein the base is selected from sodium hydroxide, sodium methoxide, or sodium ethoxide. 8. The method as claimed in Claim 2, wherein the base is lithium hydride, sodium hydride, potassium hydride, butyllithium, butylsodium, butylpotassium, phenyllithium, phenylsodium, or phenylpotassium. 9. The method as claimed in Claim 2, wherein the neutral bis(thio-hydrazide amide) is substantially insoluble in the organic solvent. 10. The method as claimed in Claim 9, wherein the neutral bis(thio-hydrazide amide) is first combined with the organic solvent to form a mixture, and the base is added to the mixture to form the bis(thio-hydrazide amide) solution. 11. The method as claimed in Claim 9, wherein between 0.25 and 2.5 moles of the neutral bis(thio-hydrazide amide) are combined per each liter of organic solvent. 12. The method as claimed in Claim 11, wherein between 0.75 and 1.5 moles of the neutral bis(thio-hydrazide amide) are combined per each liter of organic solvent. 13. The method as claimed in Claim 11, wherein between about 2 and about 5 molar equivalents of the base are employed. 14. The method as claimed in Claim 13, wherein between about 2.0 and about 2.5 molar equivalents of the base are employed. 15. The method as claimed in Claim 13, wherein about 1 mole of the neutral bis(thio-hydrazide amide) is combined per each liter of the organic solvent. 16. The method as claimed in Claim 15, wherein the organic solvent is ethanol. 17. The method as claimed in Claim 16, wherein the base is about 2 molar to about 5 molar aqueous sodium hydroxide. 18. The method as claimed in Claim 15, wherein the organic solvent is acetone. 19. The method as claimed in Claim 18, wherein the base is about 2 molar to about 5 molar ethanolic sodium ethoxide. 20. The method of preparing a bis(thio-hydrazide amide) disalt as claimed in Claim 1, comprising the steps of: Combining a neutral bis(thio-hydrazide amide) represented by the following structural formula: (Formula Removed) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a bis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether to precipitate the disalt of the bis(thio-hydrazide amide) from the bis(thio-hydrazide amide) solution. 21. The method as claimed in Claim 20, wherein the organic solvent is acetone. 22. The method as claimed in Claim 20, wherein the base is ethanolic sodium ethoxide. 23. The method as claimed in Claim 20, wherein the organic solvent is ethanol. 24. The method as claimed in Claim 20, wherein the base is aqueous sodium hydroxide.

Full Text

SYNTHESIS OF BIS(TfflO-HYDRAZE)E AMIDE) SALTS
RELATED APPLICATION
This application claims the benefit of U.S. Provisional Application No. 60/681,263, filed on May 16,2005. The entire teachings of the above application are incorporated herein by reference.
BACKGROUND OF THE INVENTION
Certain bis(thio-hydrazide amide) compounds are useful as Pharmaceuticals, in particular, as anticancer agents. See, for example Chen, et al., U.S. Patent No. 6,825,235, U.S. Published Patent Application No. 20040229952; U.S. Patent Nos. 6,762,204 and 6,800,660 to Koya, et al, and U.S. Published Patent Application Nos. 20050009920,20040235909,20040225016, and 20030195258. The entire teachings of these documents are incorporated by reference.
Salts of these bis(thio-hydrazide amide) compounds are believed to be particularly useful at least in part for reasons of solubility. See, for example Koya, et al., U.S. Provisional Patent Application Serial No. 60/582,596, filed June 23,2004, and U.S. Provisional Patent Application Serial No. not yet assigned, Atty. Docket No. 3211.1014-001, filed concurrently herewith. The entire teachings of these applications are incorporated by reference. However, the existing process includes a lyophilization step, which can be energy intensive and poorly suited to scale up to production runs.
Therefore, there is a need for an improved process for preparing salts of bis(thio-hydrazide amide) compounds.
SUMMARY OF THE INVENTION
It has now been found that bis(thio-hydrazide amide) disalts can be prepared in a process suitable for scale-up to pharmaceutical production runs.
A method of preparing a bis(tbio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to

form abis(thio-hydrazide amide) solution; and combining the solution and methyl to-f-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide).
In some embodiments, a method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl rert-butyl ether to precipitate the disalt of the bis(thio-hydrazide amide).
The disclosed methods do not require lyophylization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation.
DETAILED DESCRIPTION OF THE INVENTION
A description of preferred embodiments of the invention follows. The invention is a method of preparing a bis(thio-hydrazide amide) disalt, which includes the steps of combining a neutral bis(tbio-hydrazide amide), an organic solvent and abase to form abis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(tbio-hydrazide amide). Thus, as used herein, a neutral bis(thio-hydrazide amide) has at least two hydrogens which can react with the bases described herein to form a disalt.
Typically, at least about two molar equivalents of the base are employed for each molar equivalent of neutral bis(thio-hydrazide amide); more typically, from about 2 to about 5 equivalents, or preferably from about 2.0 to about 2.5 equivalents. Suitable bases can be strong enough to react with a bis(thio-hydrazide amide) to produced a disalt. In various embodiments, the base can be an amine (e.g., triethylamine, diphenylamine, butylamine, or the like); an ammonium hydroxide (e.g., tetramethyammonium hydroxide, tetrabutylammonium hydroxide, or the like); an alkali metal hydroxide (lithium hydroxide, sodium hydroxide, potassium hydroxide, or the like) an alkali metal C1-C6 alkoxide, or an alkali metal amide (e.g., sodium amide, lithium diisopropyl amide, or the like). In some embodiments,

the base is sodium hydroxide, potassium hydroxide, sodium C1-C6 alkoxide, potassium C1-C6 alkoxide, sodium amide, or potassium amide, or preferably, sodium hydroxide, sodium methoxide, or sodium ethoxide.
In various embodiments, the base can be an alkak' metal hydride (e.g., sodium hydride, potassium hydride, or the like), a divalent metal base (e.g., magnesium oxide)a C1-C6 alkyl alkali metal (e.g., butyllithium), or an aryl alkali metal (e.g., phenyllithium). More typically, the base is lithium hydride, sodium hydride, potassium hydride, butyllithium, butylsodium, butylpotassium, phenyllithium, phenylsodium, or phenylpotassium.
As used herein, an alkali metal includes lithium, sodium, potassium, cesium and rubidium.
The organic solvent can be any organic solvent which is stable when the base is added to a mixture of the bis(thio-hydrazide amide) and the organic solvent. Typically, the organic solvent is polar enough to dissolve the bis(tbio-hydrazide amide) salt formed by the method to form a solution. In various embodiments, the organic solvent is water-miscible. The organic solvent can generally be selected • from a C1-C4 aliphatic alcohol (e.g., methanol, ethanol, 1-propanol, 2-propanol, or • the like), a C1-C4 aliphatic ketone (e.g., acetone, methyl ethyl ketone, 2-butanone, or the like), a C2-C4 aliphatic ether (e.g., diethyl ether, dipropyl ether, diisopropyl ether, or the like), a C2-C4 cycloaliphatic ether (e.g., tetrahydrofuran, dioxane,), dimethyl formamide, dimethyl sulfoxide, N-methyl pyrrolidone, a glycol (e.g., ethylene glycol, propylene glycol, tetramethylene glycol, or the like), an alkyl glycol ether (e.g., ethylene glycol dimethyl ether, or the like), and acetonitrile. More typically, the organic solvent can be selected from methanol, ethanol, propanol (e.g., 1-propanol, 2-propanol), butanol (e.g., 1-butanol, tert-butyl alcohol, or the like), acetone, tetrahydrofuran, and methyl ethyl ketone. Preferably, the organic solvent can be selected from methanol, ethanol, acetone, and methyl ethyl ketone.
In various embodiments, the neutral bis(thio-hydrazide amide) can be substantially insoluble in the organic solvent, thereby forming a mixture, whereby combining the base with the mixture forms abis(thio-hydrazide amide) solution. Typically, the bis(thio-hydrazide amide) solution can be clear. Generally, between about 0.25 and about 2.5 moles of the neutral bis(thio-hydrazide amide) are

34. A method of preparing a bis(thio-hydrazide amide) disalt substantially as herein described with reference to the accompanying specification and examples.

We claim:
1. A method of preparing a bis(thio-hydrazide amide) disalt, wherein said method comprises the steps of:
Combining a neutral bis(thio-hydrazide amide), wherein the neutral bis(thio-hydrazide amide) is represented by the following Structural Formula:
(Formula Removed)
an organic solvent selected from a C1-C4 aliphatic alcohol, a C1-C4 aliphatic ketone, a C2-C4 aliphatic ether, a C2-C4 cycloaliphatic ether, dioxane dimethyl formamide, dimethyl sulfoxide, N-methyl pyrrolidone, a glycol, an alkyl glycol ether, dioxane, and acetonitrile and
a base selected from an amine; an ammonium hydroxide; an alkali metal hydroxide, an alkali metal C1-C6 alkoxide, or an alkali metal amide, an alkali metal hydride, an alkyl alkali metal, or an aryl alkali metal to form a bis(thio-hydrazide amide) solution; and
Combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide).
2. The method as claimed in Claim 1, wherein at least about two molar equivalents of
the base are employed for each molar equivalent of neutral bis(thio-hydrazide amide).
3. The method as claimed in Claim 2, wherein the organic solvent is water-miscible.
4. The method as claimed in Claim 1, wherein the organic solvent is selected from methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, tert-butyl alcohol, acetone, tetrahydrofuran, and methyl ethyl ketone.
5. The method as claimed in Claim 4, wherein the organic solvent is selected from
methanol, ethanol, acetone, and methyl ethyl ketone.

6. The method as claimed in Claim 1, wherein the base is sodium hydroxide, potassium hydroxide, sodium C1-C6 alkoxide, potassium C1-C6 alkoxide, sodium amide, or potassium amide.
7. The method as claimed in Claim 6, wherein the base is selected from sodium hydroxide, sodium methoxide, or sodium ethoxide.
8. The method as claimed in Claim 2, wherein the base is lithium hydride, sodium hydride, potassium hydride, butyllithium, butylsodium, butylpotassium, phenyllithium, phenylsodium, or phenylpotassium.
9. The method as claimed in Claim 2, wherein the neutral bis(thio-hydrazide amide) is substantially insoluble in the organic solvent.
10. The method as claimed in Claim 9, wherein the neutral bis(thio-hydrazide amide) is first combined with the organic solvent to form a mixture, and the base is added to the mixture to form the bis(thio-hydrazide amide) solution.
11. The method as claimed in Claim 9, wherein between 0.25 and 2.5 moles of the neutral bis(thio-hydrazide amide) are combined per each liter of organic solvent.
12. The method as claimed in Claim 11, wherein between 0.75 and 1.5 moles of the neutral bis(thio-hydrazide amide) are combined per each liter of organic solvent.
13. The method as claimed in Claim 11, wherein between about 2 and about 5 molar equivalents of the base are employed.
14. The method as claimed in Claim 13, wherein between about 2.0 and about 2.5 molar equivalents of the base are employed.
15. The method as claimed in Claim 13, wherein about 1 mole of the neutral bis(thio-hydrazide amide) is combined per each liter of the organic solvent.
16. The method as claimed in Claim 15, wherein the organic solvent is ethanol.
17. The method as claimed in Claim 16, wherein the base is about 2 molar to about 5 molar aqueous sodium hydroxide.
18. The method as claimed in Claim 15, wherein the organic solvent is acetone.

19. The method as claimed in Claim 18, wherein the base is about 2 molar to about 5 molar ethanolic sodium ethoxide.
20. The method of preparing a bis(thio-hydrazide amide) disalt as claimed in Claim 1, comprising the steps of:
Combining a neutral bis(thio-hydrazide amide) represented by the following structural formula:
(Formula Removed)
and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture;
adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a bis(thio-hydrazide amide) solution; and
combining the solution and methyl tert-butyl ether to precipitate the disalt of the bis(thio-hydrazide amide) from the bis(thio-hydrazide amide) solution.
21. The method as claimed in Claim 20, wherein the organic solvent is acetone.
22. The method as claimed in Claim 20, wherein the base is ethanolic sodium ethoxide.
23. The method as claimed in Claim 20, wherein the organic solvent is ethanol.
24. The method as claimed in Claim 20, wherein the base is aqueous sodium hydroxide.

Documents:

8343-DELNP-2007-Abstract-(06-01-2012).pdf

8343-delnp-2007-abstract.pdf

8343-DELNP-2007-Assignment-(06-01-2012).pdf

8343-delnp-2007-assignment.pdf

8343-DELNP-2007-Claims-(06-01-2012).pdf

8343-delnp-2007-claims.pdf

8343-delnp-2007-Correspodence Others-(05-01-2012).pdf

8343-DELNP-2007-Correspodence Others-(06-01-2012).pdf

8343-delnp-2007-correspondence-others 1.pdf

8343-delnp-2007-correspondence-others.pdf

8343-delnp-2007-description (complete).pdf

8343-delnp-2007-form-1.pdf

8343-delnp-2007-form-18.pdf

8343-delnp-2007-form-2.pdf

8343-delnp-2007-Form-3-(05-01-2012).pdf

8343-delnp-2007-form-3.pdf

8343-delnp-2007-form-5.pdf

8343-DELNP-2007-GPA-(06-01-2012).pdf

8343-delnp-2007-gpa.pdf

8343-delnp-2007-pct-210.pdf

8343-delnp-2007-pct-304.pdf

8343-delnp-2007-pct-409.pdf

8343-delnp-2007-pct-416.pdf

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Patent Number

254000

Indian Patent Application Number

8343/DELNP/2007

PG Journal Number

37/2012

Publication Date

14-Sep-2012

Grant Date

12-Sep-2012

Date of Filing

29-Oct-2007

Name of Patentee

SYNTA PHARMACEUTICALS CORP.

Applicant Address

45 HARTWELL AVENUE, LEXINGTON, MA 02421 (US)

Inventors:

#	Inventor's Name	Inventor's Address
1	CHEN, SHOUJUN	19 DUNSTER ROAD, BEDFORD, MA 01730 (US)
2	XIA, ZHI-QIANG	634 MASSACHUSETTS AVENUE, ACTON MA 01720 (US)

PCT International Classification Number

C07C 327/56

PCT International Application Number

PCT/US2006/018653

PCT International Filing date

2006-05-11

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/681,263	2005-05-16	U.S.A.